Increase Your Mitochondria, Your Body Will Thank You | The Acid Drop

[@marconi3142]

A low sodium diet is only for people that are mainly sedentary. For those of us who exercise and stay active, a higher sodium (sea salt) diet is much more preferred.

[@DruidzTV]

same applies for low carb diets

[@AlanNguyenMD]

you need potassium to balance sodium

[@nosretep1960]

​@@AlanNguyenMDabsolutely! I get @4-5g daily just in my homemade electrolyte drink as potassium nitrate, hence my nitric oxide also tests high. Life is hard 😅

[@LYJManchesterUnited]

Sources? Thanks

[@drSamovar]

@@AlanNguyenMDyes, and LAZY DOCTORS just tell people to cut salt, knowing they are already probably not getting enough potassium, with injurious results to their overall health.... most humans are not getting enough potassium, because it does take some education, focus ,and practice to get the daily recommendations through diet alone, but there are no shortcuts!....

[@rythmicwarrior]

My takeaway is; 1. We have evolved to fatten up in the fall and hibernate through the winter. 2. The deeper we dig into things, the more questions we come up with.

[@booswalia]

Something else people forget is that the foods that grows locally is enough to sustain and create health. Otherwise we wouldn't be here. You don't need avocados if they don't grow where you are. Find another source of good fat. The further north you go the more you need to choose meat.

[@Lykapodium]

Not sure that applies universally. Maybe for people that live in cold climates... People who live in the subtropics and to the equator can be outside year round working, exercising, etc... I think cold weather people get lazy in the fall and realize they need to look good for the beach or pool in the early spring. It's psychological for the cold weather folks

[@hoofheartedicemelted296]

Lower Fructose, Lower Sodium + Fasting for Autophagy/Mitophagy. Result = Lower Free Radicals, lower Oxidative Stress, lower Uric Acid. Thanks Dr PerlMutter, you advice is powerful as usual.

[@sweettaterpie7009]

What is best fasting regiment ? Thanks...

[@X-zk9vm]

Most nutrition for mitochondria is NIR .near infrared from sunlight especially morning and evening when the uv index is low ,below 3

[@winglau7713]

hi! there, I am wondering if you care to provide a reliable source for your statement? thx.

[@MEF7]

Can you explain please.

[@jeffreyadams648]

Doing just that. It’s helping.

[@margaretmm1627]

This study is incredibly interesting re fructose but I can’t see it tells us anything about sodium. The comparison was low sodium vs low sodium with high fructose. Unless you also compare with medium and/or high sodium combined with low or high fructose only the data on fructose is meaningful.

[@Celtokee]

That was to be my comment exactly. Thank you!

[@bryantcofty2709]

Yes, that seems glaringly obvious. Surely there's an explanation (by the researchers) regarding this point. I can't imagine what it would be though. Then again, there's a PLETHORA of poorly designed "bunk" research/studies in publication. I wonder what Peter Attia's, author or co author of a publication of some sort called "studying studies", opinion would be should he take an in depth look at it?

[@medini2]

Sodium is an enzyme inhibitor.

[@gypsypath1]

@@bryantcofty2709 At this point, I’m cynical enough to think it had to do with funding based on the “low salt = good” message.

[@LoveSumsItUp]

We are electric. Need sea salt, Need real salt.

[@franzbuchel7295]

Great presentation, Dr.Perlmutter! Please present more factors/studies how to improve mitochondrial function- would be highly appreciated.

[@cain6981]

Red light therapy, sauna exposure around 180 degrees Fahrenheit, regular exercise, and doing cold therapy like ice baths a few times a week. Low sodium diet goes against most Dr's these days

[@hd-be7di]

@@cain6981 Add Vitamin D3, the main catalyst in cell energy production

[@higherresolution4490]

Central nervous system neurons have a lot more than 1,000 mitochondria! The range is between 2,000 and 2,500. Cardiomyocytes also contain about that same number. Highly physiologically active cells found in the kidneys, liver and spleen generally number over 1,000 mitochondria. Although it's been a while, the director of the mitochondrial lab I worked in said that the current (2010) estimate of mitochondria in the ovum is 250,000. However there was speculation that the number may be as high as 1 million. Note that mitochondria compose 10% of human body weight. The number of mitochondria in the human body is roughly 10^17.

[@RAY-bg2po]

Great info, thanks..

[@kyhxx]

. sep.t3- no brnach*

[@tizzlekizzle]

Wow, thats a neat fact.

[@bienstar4349]

Mitochondria is the powerhouse of the cell…

[@johnbemery7922]

it's not a mitochondria video until it uses that phrase!

[@slobodanpavlovic3184]

*powerstation

[@charles2521]

Mitochondria are a microscopic life form that resides within all living cells. And we are symbionts with them. Life forms living together for mutual advantage. Without the mitochondria, life could not exist and we would have no knowledge of the Force. They continually speak to us telling us the will of the Force.

[@fairenough7984]

The mighty mitochondria 😁

[@vanessac1965]

Wow did you make that up?!

[@domalltobello2759]

David Perlmutter should win a Nobel Prize. Incredible video.

[@michaeltrumper]

High salt and fructose intake are a marker for a diet high in processed food. However seems to me that fructose is the driver not the salt. See Richard Johnsons' research on fructose.

[@szymonbaranowski8184]

High salt does the same as fructose, also glutamine in diet. But ofc too low salt is very bad or worse. Salt is also a driver for sure also creates uric acid reaction. But some salt before exercise is very healthy for heart providing more blood volume and so less need for oxygen for heart in hard situation or while digesting and moving with high blood requirement.

[@user-hx8th2dd5z]

So, low sodium = no significant change. Low sodium/ low fructose = significant positive change. Why didn't the study include the effect of low fructose in isolation? Also, am curious on the effects this would have on subjects not overweight-- of normal healthy weight?

[@szymonbaranowski8184]

High sodium is the same as fructose. Literally spikes uric acid the same way

[@Petunia-Greene]

Yes but combining things can be significantly different than how things work by themselves. So really both should be studied by them selves in order to get a more clear picture. Salt is highly necessary for many of the functions of the body and you can just cut it out without there being problems.

[@fourthtunz]

I agree would love to have seen the low fructose numbers by themselves

[@Myself500]

Wow! I heard that salt could cause oxidative stress but didn't understand why and it gives the answer, thanks for it.

[@MrBDezno]

I'm confused. It seems that many respected doctors & researchers have - in recent times - indicated that salt is of no concern because the body knows how to deal with excess salt/sodium.

[@michaeltrumper]

Latest research that I have seen is that people are more likely to have issues with low sodium than high. Salt intake is not an issue if you have good kidney function.

[@10outof10x]

Would have been nice to see another category that were fed just low fructose

[@szymonbaranowski8184]

@@michaeltrumper high salt intake works exactly the same way as fructose or rather causes uric acid production check out Richard Johnson talking about it deeply

[@szymonbaranowski8184]

High salt has effects. Body knows how to deal with toxins too should you take toxins? Salt also makes hungry.

[@michaeltrumper]

@@szymonbaranowski8184 True, but in context, it is much bigger risk of people having too low salt intake than loo low fructose. Or to put it another way, there is a requirement for endogenous salt, but none for fructose.

[@kulturfreund6631]

Many thanks for the information. From another video I was told that the intake of sodium (preferably in the form of sea salt or Himalayan salt, as these are rich in many other minerals) should be counterbalanced by the right amount of potassium (leafy salad, avocados, bananas etc.) and that half a teaspoon per day, especially when transpiration is increased, is a good thing to add.

[@alexforce9]

you need potassium and magnesium regardless of how much sodium you consume. Its just best those 3 to be in synergy for optimal cell energy, hydration and ofc your blood pressure. BTW - potatoes are one of the best potassium sources. They can feed you, be tasty as heck and are low calories if you are looking for that hehe. Carrots also have plenty of potassium. And fresh carrot juice is just heaven.

[@danielmason8574]

But is potassium chloride in anyway heat sensitive/damaged?

[@veniqer]

Animal products contain potassium.

[@michelangelobuonarroti916]

@@danielmason8574 No.

[@michelangelobuonarroti916]

@@veniqer They do, but the most potassium-rich food sources are fruits and vegetables.

[@STOPPOLICECORRUPTION]

Didn't know there was a test for Mitochondrial density, appreciate the info.

[@Cybernurse2020]

Agree. How or what do you order on a regular lab requisition?

[@williamkayaian7268]

Hello , right ?

[@james575730]

the company viome tests mitochondria also

[@viragkaroly2949]

They will test you anything, if you pay enough. They will also make you believe it is important.

[@tacmason]

I am retired, and I don't buy very many new books now-a-days !, But I bought 'Drop Acid" yesterday ! (It cost $ 31.76 ) Thanks for your sincere efforts to help us all !

[@angellight9500]

try your library...they have great stuff

[@davidchang8468]

Thank you very much doctor.🙏 This is the clearest and most useful clip on "polyol pathway" mechanism. Such understanding provides for important direction for elimination diets. It was my good health fortune to have listened in.

[@patriciamasterson4721]

Thank you Dr. Perlmutter. At my age 80 this. Helps to better understand why my mitochondrial function isn't balanced enough to create new muscle. And healthier skin Etc. I'll just keep up with my biodynamic agriculture foods and clean diet.

[@newunderthesun7353]

I love these theories about early man that are pure speculation, but are used to explain current medical theories. It's like being a weatherman.

[@michaelb41]

Good analogy. Imagine being without the weatherman.

[@newunderthesun7353]

@@michaelb41 Knowing what the weather is predicted to be has never changed what I do in any particular day. Sure, some people live under threat of tornados and hurricanes, but that is what the public safety system is for. Likewise, these theories have zero impact on how most people liver their lives. I can do without them both.

[@aleksandrazimpel8097]

❤😂

[@thenarethechildrenfree]

but weathermen are usually wrong

[@jjolla6391]

why did the study fail to look at just Fructose w/o a change in Salt ? did they cherry-pick it out?

[@stevelong9328]

Doctor, in the study they isolated low sodium but not low fructose separately, this is incomplete, I would be interested in a further study.

[@CarbageMan]

I read your book, "Drop Acid," and I'm skeptical of subclinical hyperuricemia in the absence of excessive carbohydrates. Are you sure the "independent" risk factors of UA are really independent at the subclinical level? I suspect there are cofactors that are not accounted for, as carnivores would all be suffering the consequences, and there have been plenty over the ages. I think fructose (or excessive other carbohydrates), for example-even in high fiber foods-is a likely cofactor, for sodium too. I'm sensing a potential plant-based bias and/or dependence on low-quality epidemiological studies. PS: My suspicion is that people who strictly control carbohydrates may not need to worry about subclinical hyperuricemia, and that in that context, sodium is also not an issue. I can't prove it, but I'd like you to tell me if you know why that's wrong-because we're both after the truth.

[@LTPottenger]

You will definitely have high uric acid levels if you eat only meat, but that does not really mean anything in and of itself. It's not the uric acid itself causing issues, though it seems that way. It is your liver (not kidneys) being metabolically deranged that makes your kidneys unable to deacidify the blood enough to keep uric acid crystals from forming. Make sense? Probably not, but it is not a simple subject.

[@curiousbystander9193]

@@LTPottenger thoughtful, thanks........let's hope the doc here deals with the subject of upper gi tract glycan binding lectins and their relationship with acidic food consumption......

[@jamesmoore5630]

Works great!!! Low sodium and 0 fructose!!! I have stage 2 CKD up from stage 3b. After addressing the mitochondria issue I have normal energy again!!!

[@now747]

So mitochondria dna has increase after 8 weeks of low sodium and fructose diet. Did this translate to the participants feeling to have more energy or had any measured weight loss? Just an increase in mitochondrial dna on it's own doesn't appear to be a useful effect otherwise?

[@Cybernurse2020]

Excellent and interesting presentation! Thanks for the many ways you help all of us learn. You're a great teacher. 🙏

[@avecrux333]

QUESTION: How do we know which is the cart and which is the horse? Do people with low mitochondrial function feel energy-starved and need to eat carbs for energy, so that's how they gain weight? Rather than mitochondrial function declining as a result of weight gain?

[@bonnieromick9397]

Please continue with U tubes. I'm a naturopathic person with HSV and I research mitochondrial support and thymus regeneration. I will watch mito u tubes more than once as I am getting very familiar with specific medical terms. Appreciate you Bonnie

[@kevb.1791]

Interested if instead of lowering sodium you raised potassium and magnesium

[@kenshey3912]

I kept walking past your book until late last month. Gout hit my ankle again. Coincidentally our health group, we had others gout confirmed by labs. Found your KZbin’s Now our group of 300 owns 30meters and wow… 75% (roughly) have levels over 7. Ordered bulk Quercetin Glycine and Potassium Citrate to start.

[@DanielTrevorOnline]

But wait, 6 grams of salt/sodium is NOT a low sodium diet.

[@medini2]

salt is an enzyme inhibitor, so it can't be that great. need All my enzymes.

[@debjordan4399]

I would have found additional interest in seeing the results of a group that was only low fructose.

[@bobhearn5671]

Letting sodium and fructose relative to what? What was the baseline level for the folks who experienced the decreases?

[@bmm9842]

I had no idea that Willem Dafoe knew so much about mitochondria. 😜

[@hohohomer4566]

You didn't mention potassium values !!!

[@williamearl1662]

The study was from 2013, have there been follow ups to confirm the finding? Also why not have seperate studies on fructose and salt? is there a synergy between them?

[@BluesDoctor]

To several who noted, yes there have been follow-ups showing NaCl is the bigger player in this. Just remember if you cut out or cut way back on Iodized Salt, you must supplement with Iodine....

[@powerpopaholic876]

@@BluesDoctorIF your thyroid wirks

[@CarbageMan]

Did they not control for only low-fructose? I saw only the comparison between low-sodium and low-sodium, low-fructose.

[@568843daw]

Hi doc, great presentation. What blood test reveals the mitochondrial count in the white blood cell?

[@neuromancer27]

I second this question, what is it ?

[@MyITRcom]

HIIT has been a clear and simple path to increasing my own mitochondria. This stress forces your mitochondria to multiply. Curious if there is any research data on combing both? I have always taken Fish and Flaxseed oil to keep my blood pressure low and scoop up free radicals etc. I am often thought to be 20 years younger then my actual age.

[@hoboonwheels9289]

Contradictory to what many find.

[@sharifahjais3524]

Sodium reduces production of ATP (interferes with the work of the mitochondria) for 3 hours (it takes the body 3 hours to get rid of excess sodium). So if you eat every 3 hours you are basically toast.

[@aleksandrazimpel8097]

Great comment. Good news for me is this- I eat once a day! Thanks 🎉

[@Project_9_subfolder_7]

If I read it correctly at 5:20, low sodium was defined as less than 6,000 mg, which is still a lot

[@jaym9846]

In the study, did they use fructose in the form of fruits? Would the antioxidants in the fruits reduce the negative effects? On a mostly Vegan diet consisting of potatoes, fruits, veggies and no added salt, my results are: Uric Acid 5.0, HbA1c 4.7% (avg 3 mo BG 86), Chol 185, TG 78.

[@lsporter88]

Thank you Doctor Perlmutter. Excellent presentation.

[@jonahbert111]

So, how does one go on a low sodium (salt) diet and not threaten the essential level of hydrochloric acid in the stomach? I would suggest using chloride forms of minerals such as magnesium chloride, calcium chloride, zinc Cl, etc where ever possible.

[@jintzie1950jth]

what kind of diet is low sodium and low fructose?

[@johnross3295]

Thank you Doctor! Liked and Subscribed. Just started reading your Grain Brain book... fascinating! Keep up the great work!

[@larsnystrom6698]

Interesting that fructose over 20 g can have such a profound effect. That would put a limit of about 4 fruits. We are now close to realize that exaggerated fruit eating is unhealthy! On the other hand, 6 g of sodium, or about 12 g of salt, most people stay below that when using it naturally to taste. And even above that, it seems to have little bad effect. Was it even sugnificant? The researchers should have tested fructose alone!

[@tanyasydney2235]

Are we talking about fructose, as in high fructose cron syryp, or fruit? Because there's a big difference between the two.

[@mytravls]

I think everything

[@johnatyoutube]

This study, or at least the way he explained it, seems to have convolved fructose and sodium impact. It should have studied them independently as well as together. That said, we're not ingesting more sodium than people years ago who didn't have these health issues. While there was a surge in HFCS in processed foods, that alone doesn't account for the explosion of chronic health issues that the public is experiencing across the board. This feels like yet another hammer trying to find a nail. More on point research is now showing that glyphosate (Roundup) is responsible for mitochondrial damage, gut flora damage, and damage to cellular protein synthesis and dismantling. Its use in big agriculture - starting in the 90s - lines up with the increase in these diseases. And there is evidence that the company that created Roundup has known about these issues for some time. But, while other countries haven't allowed or are outlawing this toxic chemical, the US government and agriculture industry have been resistant to change. The medical system is looking at everything but the elephant in the room. My conclusion is that it seems to have been compromised by both big pharma and big agriculture which share common ownership. Those of us who are damaged by years of glyphosate ingestion have to reduce our sodium and carbohydrate intake to compensate for the damage this chemical has done to our bodies. But, reducing sodium and carbohydrates won't fix the root cause of the problem. Until it is addressed, eat organic food and avoid processed food. And demand that the elephant be seen.

[@austenlawson5993]

Definitely NOT what I thought when I saw “drop acid”. This is really cool though.

[@paulafelipe1694]

Question: I see people including children on you tube videos recording extreme carnival rides like on a slingshot or Rollercoaster and often times they scream and even pass out...just wonder what is the impact on the brain..could they be doing irreparable damage?

[@SusanStoneSalas]

Thank you for your work on uric acid. In hopes that you will also study the effects of bovine growth hormones in our meat, and the who knows what they are injecting chickens and pigs with, but whatever it is, it's affecting our health in a very bad way. Almost as if they intended to wipe us out... :(

[@mikirosler]

70 times more mitochondria sounds like a lot. Does it really help to have that much?

[@michelangelobuonarroti916]

Seemed almost unbelievable. 70% increase might be more believable. He didn't link the study.

[@MrBrianDuga]

What’s the source of sodium they removed? Table salt? I imagine everything in moderation even applies to things like Redmond’s Real Salt. But specifically calling out the source could help determine if iodized table salt is causing oxidative stress.

[@janeclifford585]

I’ve had chronic fatigue years often bedridden housebound it is known the mitochondria can’t produce energy now it’s proven parts of the brain is different too

[@geraldc5165]

What about a group with high sodium and low fructose? It seems to me that this study doesn't tell much about sodium.

[@ebenezerservices6363]

Once you stop the intake of food within 48 hrs your body will start burning fat and create energy in Ketones. It works for me, I lost 50 lbs and my energy level is higher than ever before. Low carbs diet is the key and exercise.

[@brachiosaurus6541]

n the abscens of fluid, Sodium increases fructose in the blood. Drinking enough water should aliviate this effect. Too many carbs at once will also be converted into fructose. Ditch fructose, eat smaller starch meals and drink more water

[@eileenfb1948]

Thank you for putting it so clearly.

[@szymonbaranowski8184]

Water contains deuterium which damages and decouples mitochondria. Carbs, plants with starches and water is full of it. Animal fat is low and let's body make healthy water without effort of processing excess deuterium. So you literally make it worse drinking water which doesn't hydrate you..

[@moniquelemaire5333]

Okay, so my ear doctor misdiagnosed me with Meniere's Disease, and literally yelled at me "No Salt!!!". Do for more than a year I ate no or very little salt. The same year, another doctor said I had NAFLD (non alcoholic fatty liver disease). So, I gave up all soda and a big majority of sugars. I lost about 45 pounds. Since 2017, I have been dealing with MECFS. Dr. Sarah Myhill states that we should set just meat and certain veggies and no fruit to get into a paleo-keto diet to help over come MECFS. So, what you are saying is, the combination of fructose and salt just might help with promoting the growth of mitochondria???!!! What is the test and how can this test be a guide for the individual to increase their mitochondria??? What I have understood from reading Dr. Myhill and others in the world of MECFS, is that the methylation process produces more mitochondria. The methylation process is based on taking supplements. I know you want me to just buy the book,. but it would be nice if you could comment. Thank you, Miss Monique 🙂

[@alexforce9]

Sooo... here is the thing. Sodium is very important for blood pressure. So if you are on low sodium diet - then you MUST check your blood pressure. Coz low blood pressure also leads to all kind of nasty things like fatigue, depression, low energy, feeling cold, brain fog, bad digestion ect. And yeah, ditching fruits and honey and everything with fructose will help your body to get rid of the fat accumulation in the liver. Not sure how eating just meat and some vegies will be good with MECFS - glucose is the favorite energy source of the body. So giving up glucose seems risky specially to someone who have problems with energy already. You probably dont need to look into some special mitochondria treatment yet. But if you want - you can do your best to help your mitochondria - it needs b vtamins, zinc, magnesium, vit c and water.

[@moniquelemaire5333]

​​@@alexforce9Sorry it has taken me so long to reply back. Yes, I have been taking exactly what you recommended: vit. C, D3, magnesium and the others and even though I still need to lose weight, I have been experiencing more energy.... especially since I have been taking B1 for the last week or so. I have also been taking a few iodine drops for my hypothyroidism. Thanks again for the help!! Miss Monique 🙂🙏🌷💗 PS. Yes, I am drinking my water everyday 😌.

[@Alice_Walker]

This is a very small, ten year old study for which the authors themselves gave a different conclusion. "Conclusion: Our studies suggest that simple dietary measures such as reducing salt WITH OR WITHOUT restricting fructose can increase mtDNA and improve markers of oxidative stress." (emphasis added) And the findings were comprehensively questioned the following year. "We read with interest the pilot study by Hernán- dez-Rios et al. comparing the effect of a low sodium diet with or without fructose restriction under isocaloric conditions on mitochondrial DNA (mtDNA) and oxidative stress [1]. We are concerned that the reporting of the study may lead to a misrepresentation of the effect of fruc- tose on mtDNA. The title and last sentence of the introduction suggests that low fructose has an increasing effect on mtDNA. The combination of low sodium and low fructose did increase mtDNA but it did not increase it more than the low sodium diet alone without fructose restriction. This suggests that the effect appears dependent on sodium but not fructose. It is possible that with greater power, they may have detected a significant difference between the 2 groups, as there was a tendency for lower mtDNA in the low sodium diet without fructose restriction, but given the extremely large variance around the means this conclusion remains unsupported. To show an adverse effect of fructose likely requires an imbalanced, hypercaloric or hypocaloric comparison, in which fructose provides or displaces excess energy in the diet compared with the same diet without any manipulation….. there is insufficient evidence to conclude that fructose restriction has a signifi- cant effect on mtDNA and oxidative stress when holding energy equal. Energy imbalance appears to be a prerequisite for eliciting an effect. If the authors wish to build on the present pilot study. then they will need to consider using an imbal- anced, hypercaloric or hypocaloric design in which the intervention arm necessarily provides or displaces excess energy. " Dr. L. Sievenpiper, MD, PhD Knowledge Synthesis Lead Clinical Nutrition and Risk Factor Modification Centre Toronto 3D Knowledge Synthesis and Clinical Trials Unit St. Michael's Hospital Toronto

[@ronrice1931]

1:51 "...the levels of mitochondria within the red blood cells." You mean the white blood cells, of course, as you say at 2:05.

[@robertsmyk4102]

Maybe there's another explanation! Less fructose means a lower energy in the circulating nutrients and thus a compensation to get the work done with lower energy nutrition is a greater number of mitochondria.

[@zoltangaal1842]

From what you said about the study, it's not clear whether it was a low carb/high fat diet or not. You can fill up the diet with starch and it will be a low or no fructose diet. Also, I can remember you talking about the misleading dietary advice of reducing sodium intake. As you explained, salt is not sodium but sodium and cloride. You also mentioned that low sodium intake leads to worse outcome in heart patients. I do not understand your stance on this matter.

[@johnbemery7922]

Yes, it's a confusing video, my confusion is, should we stop eating all fruit? You make a good point about salt also being chloride, this chloride is what we use to create hydrochloric acid in the stomach for digestion, so instead of reducing salt, I increase my potassium foods to balance the salt sodium. I think I will be my own lab rat and give up fruit for a month and see how I feel.

[@luminousjewels4580]

@@johnbemery7922 Did you?

[@luminousjewels4580]

@@johnbemery7922 Did you?

[@johnbemery7922]

@@luminousjewels4580 Yes, cut back fruit to mostly just berries, didn't notice much of a change, have lost weight. Added a teaspoon of Cream of Tartar as a potassium source to offset my sodium, instead of actually reducing my sodium. But, also just eat one meal a day for last 3 years, lost lots of weight, I feel pretty good, hard to be sure the impact of any one thing.. I haven't been to a doctor for several years, and have not had blood tests in that time, so who knows if I am really healthy or not. But I definitely feel good with no problems at this time.

[@retire14pattaya9]

With low carb I need to ingest more salt. I have good metabolic health thus healthy mitochondria.

[@10outof10x]

High uric acid levels caused by excessive umami foods. Glutamate in red meat, organic meat, others triggers uric acid. Stan Ekberg discusses this

[@szymonbaranowski8184]

You forgot about salt

[@jimking6484]

If my blood test shows low sodium is that the same as reaffirming a low sodium diet? Sodium is a necessary mineral for electrolytes assisting in the electrical aspect of exercise and the heart.

[@littlevoice_11]

I wonder if the advice on sodium would be different if one is fasting and/or on a low carb diet?

[@CarbageMan]

I believe uric acid goes up during a fast.

[@grahamedwards6824]

Fasting appears to me to be the key. It promotes Autophagy and Mitophaggy, as well as Mitochondrial biogenesis. As well as other forms of regeneration in the body, and Neurogenesis. It reduces oxidative stress, glucose, insulin, and it seems to improve oxygen saturation in the blood. When my wife has been fasting, her O2 Sat is often 100%, which I find interesting. I'm the 'Control'! and mine is usually about 95 when lying down. It's rather like having a 'hand with all the Aces' !! And the 'Goal' is to achieve a Glucose Ketone index of 1 for maximum benefit. But be Careful...!!

[@alexforce9]

Depends - do you like feeling good or not lol. But for real - if you dont supplement with salt and other electrolytes during fast /low carb diet - chances are - you will feel like shi1. Low blood pressure, irritable, low energy, all that jazz.

[@RichardFeuille]

Why did they not have a low fructose only arm?

[@bobkoure]

I've read some studies by Rick Johnson. The polyol reaction seems to be key to uric acid levels which in turn prompts conversion of glucose to fructose (and triggering the 'uricase mutation'). His take on it (interview with Dr. Peter Attia) is that it's relative sodium levels - so dehydration can do this as well. His take on it was (paraphrasing) "if you're going to eat something salty, drink liquids first). It's an interesting area. I hadn't made the connection with mitogenesis and mitophagy but how else would an organism reduce energy consumption? Subscribed, BTW.

[@PaulLadendorf]

What was the source of fructose? Fruit? High fructose corn syrup?

[@Saelaanor]

How do we know that this is not a stress reaction where the body tries to compensate for low fructose/carb intake by creating as many mitochondria as possible to use even the tiniest amounts of carbs to get energy?

[@mikecain6947]

Do we know what happened to the energy levels, the blood pressure or cognitive function of the study subjects?

[@debrahurtado5491]

He indicates the amount in low fructose diet, but no amount is given for low sodium.

[@lesliemonaghan5853]

I heard less than 6 grams

[@robertl5298]

So, much less sugar (= carbohydrates eliminated ). Improved antioxidant situation Means LCHF, Keto, Paleo or similar low carb high health fat regimen PLUS Intermittent Fasting for Autophagy/Apoptosis and improved mitochondrial condition. Therefore for those who suffer from AF a good chance of improvement or even reversal Yes?

[@szymonbaranowski8184]

Don't forget proteins. Theta building blocks of all cells and also hormones. Check out leucine, taurine, choline. No carb is better than low carb.

[@arthurdolle5257]

What about the requirement for high sodium intake for low-carb and ketogenic diets

[@europaeuropa3673]

So it is not just in white blood cells, it's throughout all mitochondria of the body.

[@jonathanhadley2555]

Would the Mitochondria that has been damaged, be ever to repair themselves? T.I.A

[@fragranthills]

Why do you advocate consuming tart cherries? It contains fructose.

[@tahirrable]

Hi Dr David sir I am from Pakistan 🇵🇰 and your videos are very helpful for us Thank you for everything

[@oddlilbird]

Hoping things are beginning to improve, there in Pakistan, after the flood waters.

[@williamdgurley421]

I wish they would have added one more arm to this study, low fructose only.

[@hartvenessa]

How does damaged mitochondria stop weight loss?

[@Thomas-pq4ys]

Would you PLEASE post the link to this study in the lowbar? Thanks!

[@D.von.N]

20g of fructose - does that mean added fructose? Cos one apple has about that much, depending on a variety, size and ripeness. Are you saying that if I eat two apples I am at a risk of dysfunctional mitochondria? And how much salt is too much? I seem to be one of those who don't respond to salt intake with hypertension. I need to take more salt to keep my fluids in or they get flushed right through. And no, I don't suffer diabetes insipidus.

[@augustdunning]

sure looks like low or no fructose is the key here

[@nicolascamacho319]

Why not a study about low fructose and normal amounts of sodium?

[@pookiroo]

Agape 💙 .Dr. David. Ty 4 telling me the truth. I'm on it.

[@Herbert_Knavs]

How to we know that uric acid is not just inflammation surrogate marker and that uric acid isn't just ant-inflammation ingredient and its just a body normal response to inflammation due to high fructose.

[@prevengeix8551]

Seems interesting to me. Cold and heat shocking affect mitochondrial body function. Cold propagates them and heat attenuates them but this paper they seem to indicate low oxidative stress also propagates them. So 2 types of stress and 1 lack of stress improves functionality? Could this latter part because Mitochondria are proto-bacteria and potentially reproduce is a similar fashion? The DNHP and uric acid decrease seems like a benefit regardless.

[@aliciastanley5582]

So Dr. Pearlmutter: What do I do if I’m on keto and are diabetic with past history of high ( not now) cholesterol and I’ve been told I have to take more sodium due to my keto diet & greater rates of losing that & other electrolytes but I’m 68 female with Alzheimer’s big in my family so I want mitophagy & greater mitochondrial coupling. How much sodium is the right amount for me to have daily? I’m confused.

[@peter6653]

@@aliciastanley5582 want to have aswers these questions too..

[@winglau7713]

Thanks for providing the interesting finding. However, what could be the potential links between mitochondria and fructose/salts? It seems to me that conducting a study based on already obese individuals don’t make a lot of sense since they need to reduce daily nutrients intake anyway.

[@Alice_Walker]

If you do a little digging on pubmed you'll find this study was called into question with the sample size too small and the variance of results too large to draw any meaningful conclusions.

[@BetaBuxDelux]

Uh, so what can we eat? What is the best diet to support mitochondria?

[@amandatemnykh6815]

I don't understand why our ancestors's bodies would've perceived the intake of fructose as a sign food was scarce and mitochondria should down regulate to save energy. Wouldn't it be the opposite?

[@gattonelcielo]

Thank You! Always interesting and informative. What the Swedish news used from this study was the sodium angle...and how much salt there is in processed meals...

[@higherresolution4490]

Knowing what you just said certainly makes this study more understandable. Processed salt in processed foods! Natural salt has 2% trace minerals which is extracted in commercial salt. When harvested from the sea, salt contains 14% moisture. Also, sea salt has not been crushed by heavy machinery, thus causing very sharp splinters of crystal which can irritate the endothelia of blood vessels and capillaries, thus causing systemic inflammation.

[@sarrazin5]

two lapsus: 1. "White blood cells" instead of "red blood cells" is the correct one. 2. "Fructose to glucose" instead of "glucose to fructose" is the correct one.

[@toddhailey3365]

This is what makes it difficult to trust the medical industry. It’s very clear that low fructose increases mitochondria density, but they’ve always had such a hard on against sodium that they have to include lowering sodium even though it had only a trace level influence.

[@kim.in.nature.]

That study was dated 2013.

[@Stan_in_Shelton_WA]

I'd like to see the same test with a low carb group without combining salt into the evaluation.

[@virginiahurley8806]

Am not obese, not even fat!

[@applebobbingfore6221]

Did you ever think that a high sodium state really means the cell doesn't need to produce as much ATP because there isn't enough potassium to man the sodium potassium pumps?

[@chazwyman8951]

A link to relevant studies would help.

[@Alice_Walker]

" Low fructose and low salt diets increase mitochondrial DNA in white blood cells of overweight subjects" R Hernández-Ríos et al. Exp Clin Endocrinol Diabetes. 2013 Oct Some very basic digging on pubmed finds this study was called into question with the sample size too small and the variance of results too large to draw any meaningful conclusions.

[@Alphabeter]

Brooo last time I dropped acid I reverted to Islam that stuff is not a joke

[@mytravls]

😂

[@nickseccombe1357]

So we should eat less fruit? I knew salt was bad, but I am now confused.

[@alexforce9]

Salt is not bad. You need salt. Wthout salt your blood pressure will drop, your stomach acid will drop, you will feel weak and tired. The problem comes if you get salt from crappy foods - like fried chips , or when you get too much salt. The rule of thumb is - get your salt with your vegies and drink water. Also - salt to taste. Your body usually knows if you need salt or not. Fructose.... yeah...again - dose dependent. But majority of people who get waaaay to much fructose are not getting it from fruit. They get it from table sugar, soda, and packaged "food". Oreos, candy, cake, donuts, ect. Fruits themselves are natures candy. But some are high in fructose, and some are low. And if you dont have fatty liver you can be chill and eat apples and berries and stuff if you like them.

[@patphatkitten]

He said too much sodium will cause glucose to be turned into fructose. I did not know that glucose can be changed to fructose!! Too much salt is different for each person and it depends on how much potassium you eat, how much you work in the sun, how much you exercise, if you are an athlete, because sodium and potassium work together, but you need natural sea salt, not chemical man- made sodium chloride. So, yeah, eat less fruit, and less starches, grains and glucose, less sugar in general, especially if you eat a lot of packaged food full of table salt(sodium chloride).