Insulin Resistance | Ben Bikman | Why We Get Sick

Insulin resistance is the root cause of why we get sick. Dr Ben Bikman explains in his book "WHY WE GET SICK" how chronic diseases can all be improved by increasing insulin sensitivity, and lowering carbohydrates in the diet. Keeping blood sugar stable/lower will improve health overall and therefore helps any other chronic health issue or symptom of poor health.
Dr Ben Bikman is a leader in the world of diabetes research and fat metabolism. He understands the energy pathways for health and performance better than most and his book is an absolute gold mine of information on how to lower inflammation and improve your health. Everything including fertility, skin issues, cancer, and heart disease is covered in his book.
This podcast with Pete Jacobs is a great source of information on metabolism, energy, sickness and health. We hope you enjoy and grab a copy online of Ben's book. It really will open your eyes to so many health issues and how to improve them, and health overall.
Twitter/Instagram: @benbikmanphd
Facebook: @benjaminbikmanphd
Site: gethlth.com/
Amazon Preview of "Why We Get Sick" authored by Ben Bikman.
"A scientist reveals the groundbreaking evidence linking many major diseases, including cancer, diabetes, and Alzheimer’s disease, to a common root cause-insulin resistance-and shares an easy, effective plan to reverse and prevent it.
We are sick. Around the world, we struggle with diseases that were once considered rare. Cancer, heart disease, Alzheimer’s disease, and diabetes affect millions each year; many people are also struggling with hypertension, weight gain, fatty liver, dementia, low testosterone, menstrual irregularities and infertility, and more. We treat the symptoms, not realizing that all of these diseases and disorders have something in common.
Each of them is caused or made worse by a condition known as insulin resistance. And you might have it. Odds are you do-over half of all adults in the United States are insulin resistant, with most other countries either worse or not far behind.
In Why We Get Sick, internationally renowned scientist and pathophysiology professor Benjamin Bikman explores why insulin resistance has become so prevalent and why it matters. Unless we recognize it and take steps to reverse the trend, major chronic diseases will be even more widespread. But reversing insulin resistance is possible, and Bikman offers an evidence-based plan to stop and prevent it, with helpful food lists, meal suggestions, easy exercise principles, and more. Full of surprising research and practical advice, Why We Get Sick will help you to take control of your health."
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Live Your Own Fit is a Health Wellbeing and Performance Company founded by husband and wife duo Pete and Jaimielle Jacobs.
Pete is a Performance Consultant and Triathlete Ironman World Champion Pete Jacobs.
Jaimielle is a Health Expert and Triathlete Champion Jaimielle Jacobs.
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Please consult your doctor before starting any diet or exercise program. By using our videos, you understand and agree that neither Jacobs Tri Pty Ltd (trading as Live Your Own Fit) nor any persons associated with it have any liability to you for any injury or loss you may suffer in connection with any content we may post.

[@sophtayl]

Our family has a history of diabetes, heart attack, cancer, dementia, strokes and pancreas issues. This is across 3 generations and in both paternal and maternal blood lines multipletimes in all generations. I have been fortunate enough to not suffer with any of these ailments as yet ( 52yo) but the writing was on the wall ( joints, a little overweight, anxious, demotivated, etc) and I went low carb/ keto a year ago with great results and a new lease on life. ( lighter and healthier than I have been since about the age of 14.) After watching and listening to Dr Bikman for the last 6 months or so, I recently ordered 2 copies of the book. One for me to further understand the detail. The other to share with my family. Education is empowerment. It's never to late and Dr. B makes learning enjoyable and provides so many light bulbs moments that help everyone. Buy extra copies and leave a copy on your desk at work. Guaranteed someone will see it and ask about it and want to borrow it. Leverage the knowledge 👌 great work guys

[@user-co5yp2jr8n]

Keto can cause insulin resistance in the long run, despite great weight loss at first. Avoid oil. Too much Oil causes fat around organs which is definition of insulin resistance. C peptide test for resistance.

[@sophtayl]

@@user-co5yp2jr8n where does the oil come from? Which oil are you referring to? Please explain the mechanism you are describing. Vegetable/ Seed oils are a problem. But I'm struggling to understand your reference that keto causes insulin resistance considering you aren't piking insulin and how this is oils. I'm more confused by your comments

[@Mr-hn2bp]

​@@sophtaylShe meant dietary fats. Fat has the highest energy density and is in the right form for storage. Over nutrition especially in the form of fats is problematic. When the adipose tissues are full, where else can the fat go? In the tongue we get sleep apnea and snoring. In the liver we get insulin resistance and fatty liver. In the pancreas we get pancreatitis and insulin secretion problems.

[@sophtayl]

@@Mr-hn2bp sounds Luke we are confounding multiple aspects. The same can be said for excess carbs and more likely as the carbs will trigger insulin spike and conversion to fat storage. Your description of dietary fat creating insulin resistance is an interesting concept which goes against what Dr Bikman has documented. You need insulin to cause fat storage. Fat ( in the absence of carbs) has a subtle effect on insulin. Excess fat will also pass through the bowel once the bile is expended. All within appropriate quantities. Noting also that energy expenditure plays a part.

[@johnstewartvet]

Ben Bikman is one of my heroes. Great contribution on insulin

[@liveyourownfit7555]

thanks for the comment, really appreciate the support Dr John Stewart :)

[@leannew15]

Can never get enough of Dr. Bikman

[@SENORAFIFI]

X2

[@kindra3434]

I could listen to him all day!

[@rolitiwari0909]

Me too

[@irinaekpo-umo6101]

That's what I do, listen to Dr. Bikman until his teachings sink in. He has an online class, and he runs weekly on KZbin channel InsulinIQ. Highly educative!

[@jflcreate]

Dr. Bikman's enthusiasm talking about the various biochemical sequences is very infectious :-)👏

[@panaceiasuberes6464]

This should have 1MM views... its one of the most important and lucid view on human energy management.

[@aprilsaccountabilityaccoun2889]

loved when he mentioned urea being high towards the end. . When I started feeling horrible on carnivore.. I was a bit too lean (not enough fat on me) heck, I was underweight and was eating lots of organ meats (not alot of fat , pretty lean) and although I was cooking my meat in butter and animal fat, it probably wasn't enough. My urea was extremely high. Hmm...now my urea is normal and i am actually eating fattier cuts of meat bc I feel better eating that way. Perhaps that is why! Also loved how he mentioned about fasting. I was able to fast for 5 days when I started my weight loss journey, it was easy. Now I can only do omad bc I am too lean. And definately don't want my body to get at my muscle. I felt like a fail bc I had to go to omad from extended fasts. After listening to this, I don't. going lowcarb, helped keep my insulin low and fasting was succesful! Now I go to omad, keep low carb and will continue to be successful for life bc I am keeping my insulin LOW!

[@liveyourownfit7555]

thanks for sharing :)

[@jennyalvis4568]

This is a very helpful comment. Thanks

[@drumwish2010]

sure makes a lot of sense. I'm type 2 diabetic and quite possibly insulin resistant been following a keto diet for one week and I FEEL GREAT going to try real hard to remain this way so far a no brainer. thanks Ben.

[@teaheichler9735]

I seriously love this interview… I keep rewatching this!!!

[@jodienicholls9719]

So thankful for Dr Bickman! 👏🏻🙏 He has So much valuable knowledge 👍🏻

[@liveyourownfit7555]

We agree! thanks Jodie

[@kathioneill2034]

Wow! Thanks for the great questions and all the explanations! Keep getting this information out. There are so many of us trying to understand all of this and so many of you are getting this out in a format we can understand.

[@liveyourownfit7555]

You bet!

[@angatherton5236]

I’m a bit late to the table but I’ve just purchased Ben’s book as I want my husband to read it. I’ve been following Ben for a long time and being a type 2 diabetic in remission for 2 years is all down to his and others research. Too many health benefits to mention but one main issue was debilitating reflux and foot pain- all now gone thanks to low carb eating with very little fructose and zero seed oils

[@250txc]

1:16:57 -- Mr. Bikman is leading into saying : "How unfortunate" .. Too funny and so nice at the same time ...

[@jflcreate]

Real pearls of wisdom on ageing gracefully - thank you Dr. Bikman!!

[@lindabladon9205]

Now I am helping my severe migraine 😫...thanks to Dr Bikman 😑 X

[@VictoriaRoseTravel]

FINALLY, Dr Benjamin Bikman ... I bought your book. You give so much. Buying your book is the thing I can do to say THANK YOU! You de man!

[@liveyourownfit7555]

Great feedback thanks for the support of Ben through us :)

[@Christine-xs2of]

Thank you for the interview

[@brianmalpass105]

Loved this. This explains a lot of stuff clearly and simply. Have just bought and downloaded the book!

[@PS-wr2dy]

Great job with this Interview. Very helpful ! Thanks ! ☺️👍

[@RafaelBirkner]

I'm glad autophagy got mentioned here, would be great to have his opinion on IF / periodic fasting

[@ljs7wave]

Excellent!! Thank you!!

[@liveyourownfit7555]

You are welcome!

[@justmyopinion9883]

Thank you, Dr Bikman. I learned so much from this video.

[@angelluisf7730]

Only 1k views!? Unbelievable. Great interview, very interesting topics.

[@beautifulrose8619]

I found through my circle of friends and my family that they would rather not worry about eating right. They would rather get sick, take pills, complain about their health and do nothing. I feel like I'm alone in caring about my health. It's not always fun to exercise and sacrifice cake, but I really care about my health. So I believe that is why there are not a lot of views. People are watching Netflix and eating Cheetos.

[@angelluisf7730]

@@beautifulrose8619 you are not alone. I think that behavior is often due to how useless has been most advice about how to improve your health provided by the doctors. I'd bet most of those people have been on a low calories diet more than once in their life and they have been eating 5 or 6 times a day as recommend, so they lost some weight, and eventually that weight (and more) came back in spite of their effort. So there's a point in which you wonder what's the point of making sacrifices, if in the end they don't work. And you decide to do whatever pleases do, beacuse it doesn't really matter what you do, you'll be sick anyway. I know because... been there, done that. However every now and then I tried again, and failed again, which really even made me get worse (so much yoyo dieting really messed up my metabolism). That changed when I was diagnosed T2D and I was lucky enough to have a new doctor that recommended me to reduce carbohydrates (first time I ever heard about that). That allowed me to find out about fasting, keto, insulin resistance, how to deal with stress... The sources of all my health issues. I lost 68 lb in 6 months, and my health is going back to normal. So, just be patient with those people. They just heard so much BS in their lives they won't believe anything, unless they see it with their own eyes. With time, some will hopefully be more receptive.

[@beautifulrose8619]

@@angelluisf7730 Excellent points. Congratulations on your weight loss. Thank God for KZbin. I have looked at tons of videos and there is a lot of advice. Many of the recommendations are opposing. So, I have tried different things and I tend to gravitate to protocols with science behind them. I don't discuss with my friends what I am doing. My daughter does watch and imitate what I do so I'm glad that I can help someone.

[@beautifulrose8619]

@@angelluisf7730 I totally agree. Most doctors are highly trained in how to prescribe meds and not other approaches to health i.e. diet, exercise, stress reduction etc.

[@barneyb70]

Great easy to understand complex materials. As former Gut MD who during worst time, the 3rd year med school took apple cider vinegar and honey as breakfast and it was my only meal until supper. My wife name it GULP BREAKFAST as i was always running late. Happy to learn it lowers glucose. Have moved A1C from 6.1 to 4.9 on eating within 12 hrs or less window. Thanks 4 making this easier to understand.

[@SCM1949]

🙌🙌🙌 Absolutely a great interview ‼️ Dr. Bikman is such a great source of information and a fantastic human being‼️Stay safe & well❣️

[@pamelawherey4583]

This was so very interesting!! Thank you!!!

[@karenf9137]

I can't wait to buy Dr. B's book!

[@rabcatherwood8720]

Brilliant as usual.

[@liveyourownfit7555]

thanks for your support, everyone loves Ben 😄

[@Patsysmiled]

Excellent interview! Thank you🙏🏼

[@liveyourownfit7555]

Glad you enjoyed it!

[@grahamlewis6743]

Hi Pete Your video with ben is one of the best videos I have watched of hundreds. Your intence QUENSTIONS at the end WERE FANTASTIC. THANK YOU

[@kevinorr328]

Very well done! More than just a little good!

[@liveyourownfit7555]

Wow, thanks!

[@dralizairi]

very informative, thank u

[@ghazanfarmehdi461]

great work for humanity Sir may both of you live long healthy n blissful life

[@lianelindsey1407]

What a great interview!

[@bobstokoe1332]

Brilliant stuff! Greeting from South Africa 👌 👍

[@liveyourownfit7555]

thanks for the feedback and support Bob :)

[@teaheichler9735]

Seriously so amazing, I love all this information and it’s so sound!!!!! And so well balanced in humility!!!!

[@user-co5yp2jr8n]

Glad he mentioned to be careful with animal protein if your glucose is high (insulin resistant) you can get protein from plants too. Have to avoid oil too.

[@punjabikadhai481]

So informative

[@liveyourownfit7555]

Glad it was helpful! thanks for feedback :)

[@helendillard7784]

Trust Ben!

[@DeepavinSamayal]

So informative..stay connected

[@liveyourownfit7555]

Thanks and sure will :)

[@helendillard7784]

A wealth of knowledge. So important!

[@yvonnekiwior9633]

Another brilliant talk with Ben ❤... Thankyou thankyou!!!

[@markiangooley]

It astounds me how much fructose can be in grapes. One German term for glucose is Traubenzucker, “grapes-sugar,” but it’s not the only sugar in grapes…

[@heinerlauter1211]

I believe the german doc is Dr. Struntz from Roth, Bavaria

[@onyenmehieihenagarankeoma2070]

It’s 05:03 AM, I just could not stop watching. I kept going back to listen to some parts over and over. I now know why when I ingest ACV with meals, it induces both great BG and BHB readings. So ACV is actually a SCFA 😁 wow.

[@priscillanjenga1236]

What do the abbreviations stand for, I only understand acv

[@sophtayl]

@@priscillanjenga1236 BG isblood glucose and BHB is bethydroxybuterate (ketones)

[@Mr-hn2bp]

@@sophtayl betahydroxybutyrate.

[@MEF7]

SCFA what does that stand for?

[@shoegal7]

@@MEF7 Short Chain Fatty Acid.

[@runeguldberg]

What happen with number or capacity of mitochondria when adipose size is reduced significant. Does those cells have less mitochondria.

[@meditationminutes985]

❤🎉thank u❤

[@jflcreate]

LOL...on Dr. Bikman's reaction on why ACV seems to work lower blood sugar levels

[@martinirving3824]

Starch such as found in tubers is simply the plant equivalent of glycogen (stored glucose).

[@muhammadtahir8]

Dear Dr.Bikman thanks for sharing Keto IF diet & food knowledge.I am following since last 4 months.As a result that I am in ketosis state but there are two issues which are facing.(1)Cholesterol & (2)weakness are increasing in trend..So I need your advice please.

[@cosmichealth3907]

When u start keto you use ketones for energy and when body is in ketosis it's obvious to have high cholesterol...secondly increase salt intake so that keto flu goes awaay

[@truthnottradition7]

I don't worry about cholesterol as its the wrong metric *IF* one is on a low carb diet. As for weakness I have found that when I cheat and eat a little carb or sugar I feel significantly worse. I feel my best when I eat red meat with salt and water.

[@benphartine]

Boy, the information comes very fast. It might just be me but I find myself thinking and cataloging what was said and fear that I may miss some. I would really like to share the discussion with my grandkids but part of what was being said, the terminology may be a little bit beyond their understanding. I can explain it to them but many listeners may not get a complete benefit from what was being said because they lack the background necessary to understand. I would love a simpler explanation of this content with more of the terms broken down...

[@Khalidsworjd]

What do I eat if I have issues with fat malabsorption

[@miroslavmarkov5161]

Congratulations for the perfect choosen questions! Well done! Thank you!

[@liveyourownfit7555]

Our pleasure! Thanks for the feedback! :)

[@Noegzit]

Perfect chosen questions? I'm sorry but I don't agree with you. Just one example among others: do you really think that "Is sodium bicarbonate the same err... as vinegar?" is a perfect chosen question? Knowing that sodium bicarbonate is a mineral salt, vinegar is mostly acetic acid (an organic acid) and water I'd rather say it's quite a dumb question!

[@elakarczewska9042]

I tolerate bicarb without problems... I can also ingest coconut oils by the spoonful... :)

[@reezening]

Eggs, red meat and butter are all I need and want

[@user-co5yp2jr8n]

Just check your insulin resistance. C peptide test. If high avoid all oil.

[@maiaallman4635]

At 27:00 dr B mentions a test for insulin resistance. Does anybody know the name for this test?

[@lukekent9687]

Fasting insulin test I think

[@benphartine]

The test he was talking about is called the “hyperinsulinemic-euglycemic clamp, or insulin clamp” and is not done but by a few institutions, in house under laboratory conditions.

[@charlieanstey9998]

Great questions and great answers

[@liveyourownfit7555]

thanks for the support and feedback :)

[@Noegzit]

Do you really consider "Is sodium bicarbonate the same err... as vinegar?" as being a great question ? But I agree with you: great answers, even when the questions are not so great, thanks to Ben Bikman.

[@grantw7946]

Don't like frying liver? Try LIver Pate.

[@user-co5yp2jr8n]

Always check for insulin resistance c peptide test. Or homa hr test.most are resistant but dr's never check it. You cant go by glucose. An a1c just tells you how much damage in last 3 months

[@jflcreate]

"during exercise, muscles are able to pull-in glucose independent of insulin" first time I hear that

[@terriem3922]

This could make my blood pressure go down. That would be good. Natural insulin 24.

[@bobcocampo]

Does stevia have fructose?

[@liveyourownfit7555]

no it doesn't. But we would not recommend using it.

[@mr8966]

‘Insulin suppresses the metabolic rate of white fat’. Never heard that before. Could that be an evolutionary response to starvation? In that, absemt any meat source, early himans tirned to foraging and the body responded to that danger signal by conserving the burning of fat?

[@priscillanjenga1236]

Are raw fermented foods eg kimchi, saurkraut , kefir good for insulin control

[@liveyourownfit7555]

Yes, they are good for keeping blood sugar low

[@Primetime_dads]

So if fructose/fruit isn’t used as glucose “much” then why would Paul eat only fruits Apparently he’s using that as energy vs starch foods

[@hummakavula1304]

In Chinese, the term of endearment is: heart-liver or heart-liver treasure.

[@bennguyen1313]

So fasting insulin should be below 6 uIU/mL *AND* bloodcode's HOMA-IR score ( insulin (mU/l) × glucose (mg/dl) / 405 ) should be below 1? Due to differences in RBC turnover among people, I've heard A1C (6), Blood Uric Acid ( .7)? Testosterone (> 600), free-Testosterone (> 25) (Dr. Abraham Morgentaler suggests TRT should be considered if calculated-free-testosterone is less than 100pcg/ml) For example Chris Kresser suggests: Transferrin (30-40%) , ferritin levels of 80-100 ng/mL. (the usual 'Iron Saturation' test, can be used as a close proxy for Transferrin, but only if you've had your Transferrin measured at least once, and the following formula holds true: 'Iron Saturation' = ( Serum Iron / Transferrin ) *.79;

[@angelluisf7730]

Hi, about the triglycerides and HDL, I think I can give you a couple answers I found in different sources and I finally put together. There is a thing called diabetic dyslipidemia. It is caused by insulin resistance and consists on low HDL, high triglycerides and high LDL, BUT these are not really out of the normal range but just about the extreme of each range. For a male that means HDL about 40 (sorry, i think we use different units), triglycerides about 150, and LDL about 100. When I was diagnosed T2D 6 months ago my figures were roughly those. This combination typically also means the small dense (dangerous) fraction of LDL is far too much, and you're developing atheroma. When your insulin is high, the first cells that become insulin resistant are adipocytes, then liver cells, then muscle cells. Insulin does not only impair glucose metabolism, but also lipid metabolism. Quilomicrons and VLDL and LDL lipoproteins can't deliver correctly their load to the cells, so they pass it to HDL. And HDL take it to the liver, which uses them... To produce more LDL, hence high LDL. Due to extra work HDL's life is shorter than it should, they can't be replaced fast enough, hence low HDL. About triglycerides, when there is too much glucose in the blood for too long (due to insulin resistance), the liver tries to reduce it by transforming it to fat, triglycerides, hence high TG. High TG are due to high glucose, hence damage arteries intima, and to LDL, which eventually will get under the damaged intima and will stick there, causing atheroma. This is very insidious because every parameter in the test separately and total colesterol are all within normal range, or just out of it, so there are no red flags in the lab results and it's normally missed by the doctors. I recently found a blood test I had done 3 year ago, and in it I had HDL 40 and LDL 92 (so my guess is insulin resistance was already there), and TG 110, meaning glucose was still relatively under control, which makes sense because I had fasting glucose 75

[@beautifulrose8619]

@@angelluisf7730 My doctors and insurance do not provide these tests. How can you get them privately.

[@angelluisf7730]

@@beautifulrose8619 lipid profile (total cholesterol, LDL, HDL, triglycerides) is part of the typical routine blood test AFAIK. So does fasting glucose. Other tests are interesting but not that common as they should: Hemoglobin A1c, fasting insulin, c-peptide. All these test are typically covered (at least partially) by insurance, although I guess you can go to any lab or clinic abd have them done (out of your pocket). They can be expensive if you go this way though. Try talking to your doctor in your next checkup, if a reasonable person, there is no reason not to order these.

[@beautifulrose8619]

@Dust Storm This is excellent. So what kind of tools do I buy to measure glucose and ketones? So the range you got was under ketogenic healing? Thank is really awesome. Thank you for this information. I've been told by doctors that I am pre diabetic, then diabetic, (I panicked and went on a keto diet). now I am back to pre diabetic. I would love to be in the normal range. I like Dr. Boz too.

[@fathimahassan3150]

How much of protein we should eat if you are medium buily lady?

[@truthnottradition7]

It depends on how much other things your eating. It my understanding one should eat meat in the amount of the size of the palm of your hand. If your doing a keto or carnivore I'd double that.

[@Mr-hn2bp]

Don't just promote apple cider vinegar (ACV). The active ingredient in ACV is acetic acid, so any vinegar will have the same benefit, even white vinegar. Should mention about essential fatty acids from algae and fatty fish.

[@JaneEnajable]

No credit given to Dr Atkins???

[@pattihy]

I’m so confused about which fat is bad. I swore in other interviews he said brown fat was bad but here it sounds like brown fat is good.

[@jackdelane]

Brown is good, white is good in the sense it can prevent diabetes and hyperglycemia by growing....

[@jackdelane]

Brown is good because it waste energy by turning it into heat, witch since we ussally have to much energy we regard this as good

[@pattihy]

@@jackdelane Thanks :) I appreciate you responding. So both types are good, its just the location of the fat that is bad.

[@jackdelane]

@@pattihy location and quantity, if your 600lbs that's way to much white fat no matter what.... he does mention that how your white fat is growing will make a difference in how quickly it becomes a bad thing... whether your fat is growing by making new fat cells vs growing by overstuffing your existing cells.... thou neither way of growing is strictly good, but new cells are definitely better then overstuffed cells

[@jackdelane]

@@pattihy too little fat is a problem too, like he mentions reproductive function can hault in women if they loose to much weight, like those who are anorexic.... you definitely want some white fat, just not alot.... and location matters like you said.... in and around organs is much worse than on your thighs

[@250txc]

1:07:14 -- I drink coconut oil mixed with water each day on my ~7 hr dirt bike rides in the mountains with issue ...Other than take some CR tissue with you.. No hunger and energy levels stay AOK. I get most of my coconut oil from local farmers AND not the stored purchased clear stuff. MCT oils are gonna be *processed* to some degree. Buying ketones are also processed. F these shortcuts until they are proven 100% as good and safe OR you are going down the same road we all have been on for the last 50+ yrs looking for drugs and shortcuts to be healthy.. lol

[@elakarczewska9042]

I'm surprised to learn that vinegar / acetic acid is a fat... short chain, 2 carbon fat....

[@carmenross1077]

How do you treat the protien in urine doc

[@stevenmcc6052]

2 tea spoons Not Tablespoons! Of sugar in blood

[@jflcreate]

I really wish Alberta/Canada had the means to hold on to native talent like Dr. Bikman to produce value here, instead of losing them to more deep pocketed employers south of the border

[@MichaelLoweAttorney]

Mafetone is all theory, no evidence. His running heart rate training method has been canonized in the running world though.

[@carnicavegirl7214]

Actually liver is not a clean food it specifically says it in the Bible.. but if you’re not religious then it doesn’t matter🤷‍♀️I eat it

[@truthnottradition7]

I am just learning about Biblically clean foods. What verses are you thinking of about eating liver?

[@liutasx]

Ben said that insulin is causing you to become insulin resistance, but that is mechanism? I think that high insulin causes cells to accumulate energy (e.g. glucose, fats), so they become resistance to insulin. Mechanism would be not insulin causes insulin resistance, but accumulation of energy substrates make cells resistance to insulin. Have any seen a study which would investigate this hypothesis?

[@liveyourownfit7555]

"seeing" the exact mechanisms in progress and over long periods of time within the human body is not an easy thing to investigate... not sure what is or is not possible at that level.

[@yolandelucire6547]

A naturally occurring enzyme facilitates the entry of insulin into the fat cell. Maybe others. This enzyme works with normal levels of blood insulin but high levels inhibit it.

[@liutasx]

@@yolandelucire6547 Insulin binds to it receptors and active process in adipocytes which ends up in accumulation in fat. If adipocyte can't take anymore energy (it's full), they don't respond to insulin. There is no enzyme, which transport insulin into cells, if you know, so how it's called? www.mdpi.com/ijms/ijms-20-00759/article_deploy/html/images/ijms-20-00759-g001.png

[@kimjohnson6718]

Too longwinded

[@chazwyman8951]

I have to say tht Ben does not look well.

[@soteriacharis6338]

I sure wish you brilliant, educated, insightful people would STOP talking about the THEORY of EVOLUTION like it's a proven fact. You KNOW it's not. It is IMPOSSIBLE. How can you be so incredibly bright and yet believe evolutionary nonsense? SMH. Apart from THAT foolishness, I love the vid!! :D

[@rjmclean1979]

Open your eyes

[@MON-ud7sw]

Don’t agree with your premise but theory is the opposite of proven fact.

[@truthnottradition7]

You know... this is a subject I'm also passionate about. It all comes down to reality for the seen and faith on the unseen. In interviews like this I just eat the meat and spit out the bones. 😉

[@heartdisciple]

He looks unhealthy. Anyone agree?

[@michellearchuleta7881]

No, he just has very fair skin.

[@LTPottenger]

no

[@luciatopete7745]

No