T Cell Development and Maturation - T Cells are COOL!

[@madhotdogg9750]

Man you’re saving me once again, my notes couldn’t help after countless hours but 5 minutes with you and it’s clear as water. Love the videos 🙌🏻

[@InteractiveBiology]

I'm so glad the videos are helping you out. That's awesome.

[@nurulizzah9026]

Thank you for explaining such a complicated process that I try to understand in just 5 minutes 😭 I love your content, please don’t die ❤

[@InteractiveBiology]

Happy to hear that. I will try my best not to die 🤣

[@benjaminhagensieker3887]

Bro, thank you for the simple explanations. Great video.

[@InteractiveBiology]

You are very much welcome @Benjamin Hagensieker. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@user-sg5zy7if3b]

I love your personality and animations! This is very easy to understand, thank you :)

[@InteractiveBiology]

Why thank you 😃

[@LeeAz49]

@@InteractiveBiology😊😊😊😊

[@michelleotero6792]

You are so much better than my professor at explaining things. I've been lost and confused all semester until I found you. Thank you so much!!!!

[@InteractiveBiology]

Yayyy. I'm glad you found the video helpful, Michelle. That's why I make them. Thanks for following along and thanks for taking the time to comment.

[@kennyng7986]

Thank you so much Leslie!! You're saving my final exam! This is what good biology teaching should be, instead of reading aloud a textbook like my professor did.

[@InteractiveBiology]

You are very much welcome @Kenny Ng. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@viviestudy]

Amazing video! Your enthusiasm is so contagious :D

[@MaidaAslam-ml2mq]

How wonderfully you put all the stuff in anyone's mind ... Salute to you

[@jonathansadanaga5065]

Been studying for the MCAT and as someone who is not a biology major these videos have been life-saving. Thank you!!

[@InteractiveBiology]

Woohooo. You're very much welcome. Glad to hear you're finding them helpful. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works.

[@Ilillilllliliiii]

Best explanations ever for T-Cell Development!

[@jeffsinko14]

Was looking for a good video that summarizes this process to pass on to my students... this video is short, to the point, and not overcomplicated. Great job!

[@InteractiveBiology]

I'm so glad to hear that Jeffrey. I hope your students enjoy it (and learn a lot). Also, make sure to subscribe to the channel, because I have a lot more content like this coming to help your students understand how the human body works.

[@dr.nanci.]

thanks im studying for usmle and you ace the explanation of the complement system... appreciated

[@brunojose4195]

That's a nice video! I'm just a little bit confused in the progress of the events. You said that the negative selection happens in the medulla, that's right, and after you said that the T cells are exposed to other body cells to determine if they are going to be CD4+8- or CD4-8+, but that does not happen in the medule, because only single positive cells arrive at the medula. So when are the T cells expose to these other body cells to determine theyir type if not in the medule, and does it happen after the negative selection?

[@klausmaus1886]

Great video - one small mistake though I think. The cells in the medulla don’t bring antigens in from the rest of the body - the cells which exist there just express loads of other body proteins, so it’s not cells entering from the periphery that causes this. I think. They’re called mTEC cells and they’re really really cool. Great vid though

[@KendaAbuhashhash]

No FIVE minutes in the world can be more helpful !! Thank you sir

[@InteractiveBiology]

I'm so glad you found it helpful, @user-rn6ds5he6q. You are welcome. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@LegendmemesDz]

man this was very helpful , love from algeria

[@veethomasllc4118]

I wanted to come back to the page and personally say, thank you!!!! Your video made so much more sense in 5 minutes. I had been refreshing on this for a week for class. You made it click, instantly. Thank you very, very much!!! (I passed my exams). Do you have a video on the Humoral (B cell) side of this? You're amazing!!!! Thank you for what you do. Many blessings.

[@InteractiveBiology]

Wow, Vee. I'm so glad to hear that. Thanks for the comment. That's the reason I make these videos - to help people like you. CONGRATS on passing your exams. I don't have any videos on Humoral immunity, but I'll add it to my list of topics to cover in a future video. Maybe sooner than later.

[@sinquariuscreations6556]

That was a great explanation! I didn't realize that during the 3rd phase, what causes them to become T helpers vs T effectors depend on their encounters - almost like the point of a switching choice in development whether they will be female or male on the functional level (not great analogy perhaps). Question though, once they are released from the bone marrow, how long do they typically take to reach the Thymus, and go through processes within and thus released as a defined Tcell type?

[@InteractiveBiology]

That's a great question. From what I've found, it seems it takes about 3 - 5 days for the entire process. Hope that helps. Make sure to subscribe for more content like this.

[@TFYS-QA]

@@InteractiveBiology Thank you for the response. Subbed to you! Just read some of the comments below, and one person asked an interesting question about how the process of which, say a killer Tcell (CD8), would then lose its remaining CD4 receptors previously expressed through the 1st phase. If I were to guess on that, I'd imagine that the 1st phase was limited in TCR's overall, but enough to get through the last two phases, and then to be initialized to express either CD4 or CD8 based on the random selective hookup - meaning the Tcells would still have a small percentage of the CD4's left over once determined to be a CD8 type. Or some other process takes place that cleve's off the remaining CD4 receptors on a CD8 type T cell?

[@Aya-dh5dt]

Thank you so much you are the best 🌸 Could you do for B cell please

[@InteractiveBiology]

You're very much welcome. Hmm, I'm surprised I hadn't done one for B cells. I'll add it to my list. Thanks for the suggestion.

[@jadelemonade7714]

KZbin needs to pay you top dollar. Your videos explain these complex processes so well, THANK YOU.

[@InteractiveBiology]

Haha - well if you get a chance to speak to the higher ups at KZbin, make sure to let them know that 🤣. But seriously though, I' just glad that the videos are helping you. Thanks for the encouragement. Stay tuned for many more like this 👍🏾

[@neelmarzan860]

Man u don't know what phenomenal job u r doing for people.. Keep it up. Love from Bangladesh 💙

[@InteractiveBiology]

Thank you very much, Neel.

[@masm3608]

These videos that you are doing about cells in the human body are interesting.

[@InteractiveBiology]

Glad to hear it 😃

[@zeesharana5423]

Me and haseeb are listening this😂❤ yaayyy🎉

[@ashaoluayanfe7474]

Your explanation was top notch, thank you maestro

[@InteractiveBiology]

You are very much welcome. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works.

[@joymwangangye4]

This was so clear! Thank you!!!❤

[@InteractiveBiology]

You are very much welcome @Joy Mwangangye. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@B23._]

That was a great and brief explanation. Thank you so much ❤

[@InteractiveBiology]

I'm so glad you found it helpful, Batheen. You are welcome. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@ssshibe5307]

Thank you so much!!! this is incredibly clear and helpful, thanks to you imma hopefully crush my immunology exam :)

[@InteractiveBiology]

You are very much welcome @@ssshibe5307. Glad you got value from it. All the best on your exam. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@fairydust3493]

You are AMAZING ❤

[@minhduc132]

Moi da den

[@meeqo89]

Thnxfor this brief but concise explanation. My braincells are groing in numbers.

[@InteractiveBiology]

You are very much welcome @@meeqo89. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@drrrajkumar262]

U r amazing bro❤❤❤❤

[@awgoh2038]

At the end when u said they will be released as a mature t helper and t cytotoxic cells. So they still a naive t helper and naive t cytotoxic cells circulating in the blood, right?

[@InteractiveBiology]

Yes, you're right! When T cells leave the thymus, they are indeed released as mature T helper cells (CD4+) and T cytotoxic cells (CD8+). But they are still considered 'naive' at this stage. This means they are fully developed but have not yet encountered their specific antigen. Once they encounter their specific antigen in the body, they become activated and can fully perform their immune functions. So, these naive T cells circulate in the blood and lymphatic system, constantly surveilling for their specific antigen to initiate an immune response.

[@MaryellahMahenzo]

Thanks so much,,,,,,kindly can you make a video on MHC

[@InteractiveBiology]

Great idea for a video. I'll add it to my list of topics for the future.

[@konyipastrans]

Thank you

[@Zahltm]

Sir you’re brilliant and areal superhero 💜Such a great explanation

[@InteractiveBiology]

Thank you very much, @Zahltm. I appreciate the compliment. My main goal here is to be helpful. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@chimaobihillary-mu5rn]

Pls how do I get more of videos especially hematopoiesis

[@InteractiveBiology]

Just subscribe to the channel. And here's my video on Hematopoiesis - kzbin.info/www/bejne/f4OWnZd3d82ibdE

[@IAMCRizzle]

Before birth hematopoeisis occurs in the FETAL LIVER (sorry my prof really wants me to remember that)

[@nayeemaansari474]

this topic was such a head ache... thank u for making it this simple

[@ZalaanKhan-zv4wk]

Why I don't see your videos before Wow You are explaining the difficult processing in simple and easy way Thank you so much sir

[@InteractiveBiology]

You are very much welcome @@ZalaanKhan-zv4wk. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@ZalaanKhan-zv4wk]

I am from Pakistan I appreciate your video And I subscribe already your video

[@malinyamato2291]

very good explanation.... keep going.

[@InteractiveBiology]

Glad you found value in it. I will definitely keep going. Stay tuned for more.

[@livimealon]

Thank god I found this channel!!

[@InteractiveBiology]

Yayyy, I'm glad you found it too. Stay tuned for many more bio vids.

[@carinamcallister4409]

Will be recommending this channel!

[@InteractiveBiology]

Man, thanks so much, @carinamcallister4409. I appreciate every recommendation. Also, make sure to tap subscribe. Lots more great stuff coming.

[@mls564]

I love the way u teach, am from India,become fan of u

[@InteractiveBiology]

Thank you very much, mls. I appreciate the compliment. My main goal here is to be helpful. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@Trey-he4bg]

You're such a cutie. Where is your accent from?

[@InteractiveBiology]

Thanks. I'm from St. Maarten, but have been living in the U.S. since '97. So my accent is a watered-down St. Maarten accent 🇸🇽🤣

[@deepakbabupurushothaman6754]

🤍

[@Doctorwasif15]

Thank you sir what a lovely method wao ❤

[@InteractiveBiology]

You're very much welcome 👍🏾. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works.

[@aisyahhumaira199]

I just saw 2 of your video.I REALLY LOVE YOUR VIDEOS! Plus your enthusiastic demeanour and your bubbly character , it made me giggle!

[@InteractiveBiology]

Hi Aisyah, thank you so much. Glad you're loving the videos. And I appreciate the compliment. It's great to have subscribers like you. Have an amazing rest of the week 👍🏾

[@bezamengesha8515]

❤❤❤❤❤❤❤ wow wow you are wonderful .

[@InteractiveBiology]

Thank you very much, @bezamengesha8515. I appreciate the compliment. My main goal here is to be helpful. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@mirachangaming]

oh you helped me soo much thank uu :)

[@InteractiveBiology]

You are very much welcome @@mirachangaming. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@brisss_1997]

OMG thank you so much! your videos are helping me with my microbiology class! I was having a hard time trying to understand T-cells. I wish you were my professor lol

[@InteractiveBiology]

You are very much welcome @Brisa Rojas. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@bilgeatay9146]

thanks for very clear explanation... very helpful for my immunology exam

[@InteractiveBiology]

You are very much welcome @Bilge Atay. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@mickaella7974]

THANK U THANK U SM

[@InteractiveBiology]

You are very much welcome @@mickaella7974. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@LopLo-vb3lq]

amazing this is all what I can say

[@InteractiveBiology]

I'm so glad this was helpful for you, @LopLo-vb3lq. My goal is to make biology as clear as possible. If you want more explanations like this, make sure to subscribe - I have a ton more on the way!

[@DrKevynOliveira]

Perfect, as always.

[@InteractiveBiology]

Thanks, Kevyn

[@dhanasreejith9362]

Man you are a life saver

[@InteractiveBiology]

I'm so glad you found it helpful, @dhanasreejith9362. That's awesome. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@helinahamd]

U saved me best teacher

[@InteractiveBiology]

Yayyyyyyy

[@marean_mat]

Thank you, sir! Amazing work!

[@InteractiveBiology]

You're welcome 👍🏾

[@nejateshetu7826]

Well done 👏

[@InteractiveBiology]

Thanks.

[@eumhiralejandrino885]

How this so easy

[@InteractiveBiology]

I'm glad you find it helpful 😃

[@Cookiecream4250]

Ah my man again❤❤...hoo😅

[@InteractiveBiology]

👍🏾

[@syedazainabafzaal6125]

Amazing video 👏💯

[@InteractiveBiology]

Thank you very much, Syeda Zainab Afzaal. I appreciate the compliment. My main goal here is to be helpful. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@wycliffenyandika9017]

thanks for the video,the best explanation on KZbin so far,tho from 5:48 going forward I did not understand most of it, what is that process? is there another video you can refer me to read more about it

[@InteractiveBiology]

5:48 is the end of the video. So I'm not sure what you're referring to. Was that a typo?

[@nicowhitlock9381]

love the energy man

[@InteractiveBiology]

Why thank you. Stay tuned for more like this.

[@nosaibabahr810]

Very informative

[@InteractiveBiology]

Glad to hear it, Nosaiba. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works.

[@azrieloni258]

I'm a biology professor and I have a hard time understanding all the complexities of t-cell development. This video made it so easy to understand those complexities. lol

[@InteractiveBiology]

Yayyy. That's exactly what I was going for, Lyle. And hey - I understand how it is being a professor and not understanding something fully. Always an interesting challenge. Glad I was able to support you on that. Make sure to subscribe for more like this.

[@lr2683]

Greatly explained. Thank you so much.

[@InteractiveBiology]

I'm so glad you found it helpful, @lr2683. You are welcome. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@randomyoutube844]

Thank You So Much

[@InteractiveBiology]

I'm so glad you found it helpful, @randomyoutube844. You are welcome. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@theartistkat6985]

amazing work, I understand so well now!! thank you!!

[@InteractiveBiology]

You are very much divine @TheArtistKat. Glad you got value from it. Make sure to subscribe to get more content like this 👍🏽.

[@zinathjahan1722]

Thank ya dude❣️

[@InteractiveBiology]

You are very much welcome @Zinath Jahan. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@nevilbritto8864]

Man the way u explained this difficult concept>>>

[@InteractiveBiology]

Thanks, Nevil. Glad it helped. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works.

[@wonderingmerchant]

This Mr. Makes biology fun and simple to understand. Thus is helpful in my undergraduate program

[@InteractiveBiology]

Glad to hear it, Joshua. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you with biology.

[@mariamazam9688]

Thankyouu. It was helpful AND enjoyable💕

[@InteractiveBiology]

You are very much welcome. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you with biology.

[@Stop-and-listen]

Can we develop an organoid that duplicates the thymus?

[@InteractiveBiology]

Great question, but I have no idea 😃

[@deekshithagbmbt632]

You are amazing your animations are amazing keep this lectures going👍😊

[@InteractiveBiology]

Thanks. Glad you're finding value in the content. I'll definitely keep them going 👍🏾

[@ingamalysheva2582]

*THANK YOU SO MUCH, AMAZING VIDEO!!!!!*

[@InteractiveBiology]

I'm so glad you found it helpful, Inga. You are welcome. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@fuadgn1239]

mantap

[@khadarali9655]

Well done

[@InteractiveBiology]

Man, thanks so much, @khadarali9655. I try hard to break things down in a way that's understandable. So if you wanna keep learning like this, make sure to tap subscribe. Lots more great stuff coming.

[@kingdavidjapan]

Wow, great summary! Thanks 🙏

[@InteractiveBiology]

You are very much welcome @kingdavidjapan. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@Piji.S.2]

Thanks!

[@InteractiveBiology]

Just realized you left a "Super Thanks". Wow, I'm so grateful. Thank you very much.

[@autf2_6]

So good animations! Thank you teacher.

[@InteractiveBiology]

You're very much welcome.

[@nathancheese8645]

Thx

[@InteractiveBiology]

You're welcome!

[@kotana2391]

thank you

[@InteractiveBiology]

I'm so glad you found it helpful, @kotana2391. You are welcome. If you haven't already, make sure to subscribe to the channel because I have a lot more content like this coming to help you understand how the human body works.

[@aydazarei1929]

That was perfect. Thank you❤

[@InteractiveBiology]

You are very much welcome @Ayda Zarei. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@notnabsar]

👍🏿

[@InteractiveBiology]

👍🏾

[@nikkenzgraphics8351]

Can you suggest a textbook or me

[@InteractiveBiology]

Textbook for which subject? A great place to find free textbooks is pulse.ly/y7tdy6n3kk

[@nikkenzgraphics8351]

@@InteractiveBiology Immunology

[@InteractiveBiology]

I'm actually not sure which Immunology textbook to suggest because I haven't looked at any in so long.

[@zainahziyad2036]

❤❤❤❤❤❤❤

[@InteractiveBiology]

👍🏾

[@joshuabowman7210]

You shared the most Information thanks

[@InteractiveBiology]

You're welcome.

[@shiraziahmedsheikh6365]

Thanks 👍 A great and consise video

[@InteractiveBiology]

You're welcome 🙂

[@simisiby1446]

Thank u

[@jasminevaughn5214]

What about smuge cells what is that

[@InteractiveBiology]

Smudge cells are a kind of white blood cell that appears "smudged" when you look at them in a microscope. They are often seen in people with Chronic Lymphocytic Leukemia.

[@jasminevaughn5214]

@@InteractiveBiology I have smudge cells but I'm terrified

[@InteractiveBiology]

I recommend taking it one step at a time. Smudge cells are even seen in healthy individuals. So it's not necessarily an indication that there's a problem. I would check with your physician for further evaluation.

[@jasminevaughn5214]

Are they t cells?

[@InteractiveBiology]

They can be B or T cells

[@tenzinyangzom9056]

Wow! Thank you.

[@InteractiveBiology]

You're welcome.

[@ShayanKhan-yp5yx]

amazing!!!!

[@InteractiveBiology]

I'm so glad this was helpful for you, @ShayanKhan-yp5yx. My goal is to make biology as clear as possible. If you want more explanations like this, make sure to subscribe - I have a ton more on the way!

[@ShayanKhan-yp5yx]

Definitely Subscribed :)

[@InteractiveBiology]

You're awesome.

[@no-eb2fr]

Hey,what is the process of losing cd4 or cd8 called?

[@TFYS-QA]

Did you ever get your answer?

[@no-eb2fr]

@@TFYS-QA no but i dont care as my project is done

[@TFYS-QA]

@@no-eb2fr Ah you must be a student. Still, I thought your question was good and has me interested. Lucky for me, I have no tests to prep for. I'm just curious on how these things work. Best of luck in your exams :)

[@no-eb2fr]

@@TFYS-QA thanks

[@nalavwememory8763]

👏👏👏👏👏👏👏

[@suryamsingh5276]

Love this 😮😊

[@InteractiveBiology]

Thanks, Suryam. Glad you enjoyed it!

[@XeReF-lr8jo]

Thank you so much man! It was so tough for me to understand all these concepts from textbooks but you explained them so easily.

[@InteractiveBiology]

You are very much welcome @XeReF. Glad you got value from it. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you understand how the human body works 👍🏽.

[@abdilahiismacil8381]

Amazing lesson

[@InteractiveBiology]

Thanks. Glad you found it helpful. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you with biology.

[@Heyokasireniei468sxso]

great job man

[@InteractiveBiology]

Thanks, Rex. Glad you found it helpful. Make sure to subscribe to the channel, because I have a lot more content like this coming to help you with biology.

[@Stop-and-listen]

Great explanation. Lots of questions. Love it.

[@InteractiveBiology]

Glad to hear it.

[@42akasha]

I still can't understand the diagram although I understand cycle complety..wasted time