Is Aging a Disease? Epigenetics with David Sinclair & Neil deGrasse Tyson

Is aging a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary O’Reilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair.
What is epigenetics? Discover the difference between genetics and epigenetics. We discuss whether aging is a disease and if there have been any changes in aging throughout the centuries. David breaks down the information theory of aging and how epigenetic inheritance works. Plus, Chuck tells us about some of the studies he’s reading and how behaviors during your lifetime can be epigenetically passed onto your children.
Could we someday cure death? What does aging look like in the broader animal kingdom? We look at aging from an evolutionary standpoint, restoring vision in blind mice, and what the length of your telomeres tells you. We break down conflicting information regarding diet and how to not just live longer but live younger, longer. What are the genes that control aging?
We break down what anti-aging medicine would look like and whether it would be affordable for everyday people. Learn about the world's oldest mice with the youngest eyes. We discuss the Yamanaka genes and how they can be utilized to turn back time on a cellular level. Is DNA destiny?
Thanks to our Patrons Jason L, Daniel Holzmann, Anne P Vance, Unknown, Myles G Blanton, Paul A. Straus, and Gregory Dees for supporting us this week.
NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free.
Check out our second channel, @StarTalkPlus
Get the NEW StarTalk book, 'To Infinity and Beyond: A Journey of Cosmic Discovery' on Amazon: amzn.to/3PL0NFn
Support us on Patreon: / startalkradio
FOLLOW or SUBSCRIBE to StarTalk:
Twitter: / startalkradio
Facebook: / startalk
Instagram: / startalk
About StarTalk:
Science meets pop culture on StarTalk! Astrophysicist & Hayden Planetarium director Neil deGrasse Tyson, his comic co-hosts, guest celebrities & scientists discuss astronomy, physics, and everything else about life in the universe. Keep Looking Up!
#StarTalk #neildegrassetyson
00:00 - Introduction - David Sinclair
02:28 - What Are Epigenetics?
5:03 - Is Aging A Disease?
7:33 - Information Theory of Aging
9:31 - Epigenetic Inheritance
15:23 - Do Some People Age Differently?
16:56 - Could We Never Die?
21:13 - Is DNA Our Destiny?
22:23 - Aging in the Animal Kingdom
24:30 - Curing Blindness
27:29 - Telomere Length, OSK Therapy, & The Hallmarks of Aging
30:35 - StarTalk Patreon
32:18 - Can You Cure Aging?
34:25 - Neil Wants Immortal Mice
36:58 - Using AI for Gene Therapy
38:17 - NAD & Yamanaka Genes
40:48 - Biological Stress & Lifestyle Effects on Aging
45:23 - Closing Thoughts

[@StarTalk]

Would you want to live forever?

[@shannonharris]

Nope, not in this world... No thank you. Stop the planet, I want to get off!

[@alieubadaranjie2928]

As a 24 year old in his gray, who started going gray at 14…Yes, I see few downsides.

[@cheapskatepanic]

No. I watched this episode over a mushroom swiss burger.

[@peznino1]

80% through this I'm glad to see Neil is not buying it. Guys and Gals, please wise up. This guy is a spoofer.

[@Jesse-Summers]

Maybe humanity is the result of living forever, it sounds silly but we look at humanity as billions of lives, what if our precoded DNA is in actual fact the result of one single entity that exists though a conduit such as us aka humanity. As long as we exist, we will always be 1, not billions...

[@spokehamilton6624]

My telomeres have shortened just having to wait through all these commercials.

[@user-rp1lq9ws5l]

Lol

[@Richard-ug4el]

Should've asked for longer telomeres, huh?

[@MusingsFromTheJohn00]

ROFL. Your comment slightly increased the length of my telomeres after they were noticeably shortened by those commercials.

[@WagDizzle89]

😂😂😂

[@JJs_playground]

Get KZbin premium, just think, for $12/month it will increase your lifespan. 😂

[@mollymcguire198]

My grandfather's 93, in perfect health. Treated his body as a temple, truly. He ran at least 4 miles a day until he was about 84 years old. We joke that he'll out live the family but we're starting to think he just may!

[@powmod]

Had an uncle that lived to 105 years old. Worked on a farm 50 km from any hospital. He used to walk up the hills of the farm without a crutch for his whole life every single day. He used to preserve food in pig fat since there used to have no electricity on the farm.

[@tahchridaya]

One of my teachers lived to be 116. He was a true yogi. I met him when he was around 100 and we were in our 20s and he could out walk us all!

[@ki5ngau]

Not may. Will be.

[@aohjii]

im going to live at least 500+ yaers old

[@svendtang5432]

Please and you know that others who have done the same suddenly get cancer or knee that give up.. I think most of us know that a healthy life style is helpful in keeping body defence system intact but it is no guarantee I had a friend who his whole life kept fit and ate healthy and he is now 60 and has Parkinson decease.. The anecdotal evidence is no evidence and the fact that he’s using the sample of one himself to say he’s keeping young be doing x or y in all respect is not even an indicator

[@jamesopio4898]

Chuck prepared for this podcast, meanwhile my astrophysicist was swimming in unfamiliar waters. 😂

[@Corfal]

His chromatin remodeling comment/question started a good conversation

[@macysondheim]

Not “your” astrophysicist. & what an incredibly racist, insensitive, inappropriate comment to make .

[@andanssas]

@@macysondheim what?! 😵If Neil is one of James' primary sources of astrophysics/science knowledge, why is that "racist, insensitive, inappropriate"!? 🤯 Please clarify...

[@Spree86]

@@macysondheim I'm pretty sure his wording is in reference to how NDT calls himself "Your personal astrophysicist" in the closing of these StarTalk videos, and not related to his race.

[@bertdemeulemeester]

​@macysondheim woke, easily triggered leftie spotted.

[@edwardyork7396]

This the best show seeing Chuck out there showing how great his questions really are. Great job Chuck!

[@masongovender9231]

Fully agree, he is so well read and prepared. Not to mention his delivery and timing of his punch lines.

[@Antispor]

Chuck Nice is so underrated. Love him so much lol

[@TheAntonv88]

true

[@jaimepoliveira8616]

The first thing that came to mind is that this could be great for interstellar travel. Extend life for long journeys outside our Solar System, rather than trying to travel at the speed of light, missing opportunities for great research along the way. On Earth, the average of 90 years is enough for many who have no interest in space travel, but for those who dream of getting to know the universe, they need more time to at least travel within our galaxy. Jaime P Oliveira

[@iohio8677]

The average is 90? Wooohooo!

[@jaaandro]

I've always thought about that, maybe figuring out the speed of light is the wrong approach and it would be better to try to work on extending life or putting our consciousness in something that lives longer

[@TheBowersj]

Time dilation is 4.22 light years to nearest earth candidate Proxima Centauri B from Earths perspective, but to the traveler they would only experience 0.001407 years traveling at 150,000 m/s squared with a 453 KG spacecraft.

[@itachis2gaming882]

Yea this is the main reason we need to do this. We are too small to explore our universe. We need longer lives to be the explorers we are meant to be

[@jae2883]

I think more research needs to be done on cyrotechnology

[@allensanders5535]

I'm 65 and I want to volunteer at his lab he can experiment on me, we'll see how well it works I'd love to be 40 or even 50 again.

[@heinousanus9352]

Why not 30? 🤔

[@demonz9065]

@@heinousanus9352 because hes trying to be realistic about what early days lab testing can achieve? its not like we're gonna just pop out a 100% age reversal to prime drug in one go.

[@33Crazydude]

@@heinousanus9352, I'd like to be 21 😅

[@eduardocod8924]

I bet only rich people will have this in the future

[@vigoliebregts]

To bad

[@Adam-nw1vy]

Glad to see David Sinclair after a long time. I've been following him since 2016 and been a huge fan. Unfortunately, there have been a few controversies surrounding his work recently. Also, there's a doctor from New Zealand called Brad Stanfield who regularly criticizes him with seemingly well-researched and balanced takes. Would be great if Dr Sinclair could dedicate sometime to address the issues raised by Dr Stanfield, particularly when it comes to NMN.

[@Seanonyoutube]

Hahaha that will never happen because Brad is 100% correct and he is a total fraud.

[@longevitycoach1573]

Sinclair is a charlatan.

[@brysonraile8395]

This video has nothing to do with nmn

[@capgains]

@@brysonraile8395paid ? Or engineer?

[@GeraltBosMang]

Controversies? Sinclair allegedly committed fraud against big pharma.

[@travishalvorson6377]

I actually talked to David 10 years ago. Really nice guy. Said at the time, he couldn't recommend any supplements to take, because nothing was proven. I was taken back by how open he was just to talk to the general public and his honesty about his own research and his realistic approach

[@Apjooz]

That definitely makes him more trustworthy.

[@imadeyoureadthis1]

There's been controversies lately regarding Sinclair and his past work. He could be a nice guy or he could be a fraud. We'll see in the future.

[@CreativePublisher]

@@imadeyoureadthis1 he runs several biotech companies and even sold one for $750 million. everyone should keep this in mind while listening to him. he may have some interests.

[@andanssas]

@@imadeyoureadthis1 indeed, I've watched a few of those controversies on Brad Stanfield's channel... Resveratrol and the experiments on mice particularly, it doesn't look good for Sinclair. 🤔

[@gmichia]

Doesnt he look much younger now?

[@riskninja8194]

One of my fav interviews so far! Your guest was fascinating to listen to!

[@Theanalyst-pz1ui]

I am a data guy, and I don't think population will increase. If we look at what happened last time life expectancy doubled. We went from having 7 children, to 2 children. We went from having children at 15 and 16 to children at 25, 26. This is because back in the 1700 and 1800s people only lives to be 30-40 years old. If you were 15, or 18, you were middle aged. Now we frown on teen pregnancies. I think based on what happened last time we doubled the life expectancy, people will wait longer to have children, and we will go from 2 children to negative birth rates.

[@animeboi4010]

Here in Africa we still having 7 children minimum. And teenage pregnancy has become a normal thing. We so many, 30% can't even get employment

[@Theanalyst-pz1ui]

@@animeboi4010 Good point, if you lived to be 250 years old, 50 becomes the new 20. The reason you would want 7 children is normally to help with farming, and to take care of you in old age. However as countries become more developed, and life expectancy goes up, education increases, people tend to see less reason to have so many children. This is because Farming goes down, and well people start living longer. So no need to have so many children for old age or to help with farming. People are also selfish. Alot don't want to spend their early years taking care of children. So population decreasing in countries like japan, or even india is just natural. I suspect countries in africa like Nigeria or Ethiopia, egypt, will start to decline in birth rate as development continues. Its not instant.

[@davidderidder2667]

Truly brilliant interview, historic. I am following this field and the work of Dr. Sinclair for years but this was a very good interview with very pointed answers and questions. And the moments of light humour, well that was just splendid. Compliments Startalk! I will support you.

[@gloriouslysarcastic8000]

Chuck is the real genius here!

[@tyrone4u559]

Fascinating episode

[@palawansen]

Love this series ❤ Keep going! Love you Gary so much, you always ask what I would have asked😊 Great guest💫 Cheers!

[@leonardopinhogomes2101]

This video was just… Excellent !!! In content and how it was so well explained, about a matter that is intrinsically so important to all mankind!

[@JJs_playground]

Im blown away by Chuck's level of knowledge on this subject.

[@snowbear441]

I really enjoyed this podcast. This topic is so fascinating! Please do more of these. Thank you

[@therecogniser2122]

Great questions and great answers as always, thank you so much Startalk.

[@Shat_Tastic]

I cant believe they got Sinclair on here :) been follow him from the time i went blind in one eye. Nerve damage sucks lol

[@HouseGuide]

You need his gene repair therapy now. If it has worked in mice, dogs and monkeys and not caused any damage then it will not cause any damage in humans. Let some people volunteer and after 6 months with no bad effects, offer it immediately to the public. People like you cannot afford to wait 5 or 10 years. Write Dr. Sinclair and ask him if he can give it to you.

[@sharpcircle6875]

Is it me or does Sinclair looks way younger than in his older apparitions? He's really taking this living forever thing very seriously it seems :v

[@user-we3yg1tx4u]

You probably should also look up Dr. Michael Levin on this topic.

[@Shamwilder]

I was just thinking he looks different ​@sharpcircle6875

[@taahirahchothia6036]

I hope you ok. Have you done anything that you learnt to support the eye.

[@sakismpalatsias4106]

Aging is an evolutionary lay over, that served a purpose in the past. In order to overcome our prior evolutionary hurdles, we developed an intelligent mind.

[@plazadepaul]

Finally, people being honest, truthful, open and brave, and not those insane topics and sidetracks and delusional psychotic monologues that were recited back to the guy who wrote the crazy bible itself. I'm proud of us. ❤

[@GizzyDillespee]

Hey, watch yourself and each other, just look around from an ET's point of view, and you'll know we're not the endpoint of life's evolution. We're still in the teenage phase, as a species - more power than wisdom🤣. We'll each die, no matter what the clickbait says. Imagine the hubris, to think we are the endpoint of evolution, that no improvement could be made to the human form or brain, and that we won't die. If that's what people have been led to believe lately, then no wonder the world's gotten weird. Each human is born with these competitive urges that you say we've evolved past. We wish we had evolved past them, but in reality we have to do a ton of hard work to not be controlled by the impulsive and harmful aspects of "human nature". That's what spiritual training is. It's so difficult because "capitalist society" means a society whose rules take advantage of those competitive urges (thru incentives and punishments) in order to keep the goods and services flowing. That's really the source of the clash between spirituality and western culture.

[@plazadepaul]

@@GizzyDillespee Yeah but you're competing for a better society and future for all, and that includes immortality and capitalism is very conducive to that. Your reasoning and reality assertion skills seem faulty, you might be bipolar. Imagine your bewilderment when you look back on your comment and realize YOUR hubris, when simply through your attitude you're an enemy to yourself, your family and humanity itself. Sure, other species probably already got way further, yet they were at a stage similar to ours once. We're the end point of evolution on our planet and we can and need to aspire to be equal to the top tier civilizations in the universe. Spirituality is rooted in physicality, there's no 2 ways about it. And whilst spirituality promises infinity, paradise and immortality, those promises are rooted and predicated in each and every one of our bodies and we must achieve our goals. Otherwise what ethereal, nebulous, otherworldly spirituality are you referring to? Bowing down to creation and accepting death and mockery from all other extraterrestrial civilizations? Pass.

[@Synathidy]

We developed an intelligent mind? (looks around the planet) No we didn't.

[@plazadepaul]

@@Synathidy You're spreading your lies using a technology developed by us, when something like this would have seemed improbable/impossible just a few decades/centuries ago. Stop looking around the planet and look inside yourself, stop being negative, a pessimist and a hater, deal with yourself before you try dealing with us/humanity. Because I look around the planet and I see humanity taking care of you, from the phone you probably used to post it to the food you ate yesterday, to the toilet paper you benefited from. You attempt to sound smart or funny, but you sound like a bad joke, cynicism is ridiculous and the demise/death of our race wouldn't be seen as funny by no one. Read the room.

[@eddiecampbell3514]

Gotta love Lord Nice's impressions they are often spot on. Even if he's channeling his inner dr and recalling things he remembered about certain studys that have already taken place.. has a great recall memory when it comes to that.. I think Dr. DeGrass is rubbing off on him some so he's been in startalk dr college courses lol love it he's also gettin smarter everyday as well as us just watching the shows regularly! Love this show.. its my favorite by far.. I'm always interested in watching a new video and alway always always save it for later that day if I couldn't watch it right away because I'm at work and I don't wanna miss a show.. keep looking up folks!!! I know I love to at night when it is its darkest out and not so many lights on. Fun to see the stuff zipping across the skies at night almost on a regular basis for me anyways... but I think some of that is just a satellite repositioning in some areas.. ( just my thought) but fun to watch bc sometimes I see something smack into something and knock it across the galaxy

[@kasamukabirudawa7900]

Great talk to listen to in my 41st birthday. Best birthday gift ever. This gives me hope I can still rejuvenate 😊

[@MikeJamesMedia]

Hugely interesting. Thank you!

[@Rob-eg8qc]

Both of my parents are nearly 100 years old and are still in rather good health, their parents lived will into their 90s too. I and my 2 sisters are into our 60s with no health issues, maybe just lucky, but personally I also think it has something to do with your genes past down from your parents, having 1 balanced meal a day gives your body a chance to repair itself rather than spending most of its time digesting food, I'm not to sure, but I definitely think genes play an important role in longer life, great show, all the best from the UK.

[@macysondheim]

Your luck will run out sooner or later m8, don’t hold your breath

[@stevetennispro]

@@macysondheim Good suggestion. I hear if you hold your breath for... too long... you will die. ;)

[@GlacialRidgeHomestead]

You have good genes

[@quandmeme9970]

The longer you live, more beloved people and pets are dead and you more and more want to connect with them.

[@Rob-eg8qc]

@@macysondheim I best enjoy my luck whilst it lasts then.

[@mattyj101]

One of the greatest topics of human history, examined by and researched by some of the greatest, most resourceful, single-minded, sometimes cruellest people who have ever lived, and obsessed over by many. A touchy subject indeed.

[@jozette-pierce]

Dr. Sinclair is super, and so helpful to the average person. Thanks for having him on.❤

[@vickieysacoff4249]

This research is so fascinating! Another great podcast.

[@tyrone4u559]

Outstanding video, very interesting. I think there is no doubt that the biological aging process thing will be figured out, hopefully soon

[@gregbailey45]

Dr David's onto it!

[@chaokai3606]

Such an interesting topic, really enjoyed this video and good explanations aswell :)

[@donbazukon9620]

Hey pops! Great topic. Thanks so much for awakened all that enthusiasm I had about science in school. With your videos I'm learning and getting everything so clear now. Thanks

[@userrnoise2777]

Awesome show

[@oneofus6924]

every time i see David over the years, he looks younger and younger. he is really walking the walk

[@Valentin_Teslov]

His face is full of botox. I used to believe in him, but doing plastic surgery isn't helping his case...

[@Freeformax]

I have to agree, nothing against his research he’s giving us a lot of hope if no one wants to get old, but his face looks weirdly smooth, around his eye looks worked on and even the way he’s set up the lighting.. Benjamin buttoned himself

[@chrisbusby4395]

@@Valentin_Teslov don’t forget the hair dye and turning down clarity on video setting to smooth down highlights

[@jorn-michaelbartels9386]

Great video! Your guest David Sinclair explains all the science behind aging in a very clear and simple way. I heard of his projects first in a video of nature. My congratulations that you had him as a guest on your channel.

[@SimonJanoSessions]

always a good 👏👏👏 for Chuck and Neil! and also for David.

[@raychang9512]

It's one of the best interview of Dr. David Sinclair.

[@starspace4529]

interview of snake oil salesman?

[@chriszzw30]

He is proof you can't change ageing. He doesn't look anything but his age, a bit weird but not young. A joke. Still, probably all the chat justifies a nice check for him.

[@dondajulah4168]

I thought it was common knowledge at this point that Sinclair is a fraud.

[@dondajulah4168]

@@chriszzw30not only that, but plenty of people look great in their mid 50’s and die young

[@h0ph1p13]

@@chriszzw30 I was very impressed by his claims at firs but... Collagen, hair transplants and stuff like that can fix many things. It's how movie stars look 30-40 yo well into their 70s. On the other hand -- There is quite a bit of info on the internet on how he tricked big pharma into buying his company for 700 mil or so. Then turned out the research his company was doing was a "misunderstanding". They did sue him but could not get trough his alibis. Now he's making another research company probably to repeat the 'trick'. Meanwhile selling supplements, books to the likes of us.

[@-Mohog]

Quite amazing. This is also interesting regarding space traveling. If we can increase our lifespan significantly, we don't have to worry about the distances and time it takes to travel from one place to another quite as much then anymore and it would make it possible to make longer trips even if we won't discover some new amazing way to travel significantly faster. Although the distances in space are so vast the lifespan increase should also be quite immense. But at least in our Solar System and perhaps even enabling us to travel to Proxima Centauri and back within a human lifetime could become more of a reality. Perhaps even a few other closest star systems. Very intriguing interview and information.

[@maniacslap1623]

Definitely. Generation ships are legit with humans living 200 years. Also helps the communication thing too because aka a 10 year reply time doesn’t sound sooo bad lol

[@gotxe]

This was a great talk, thanks!

[@alexharvey9721]

Excellent interview, thanks! All jokes aside, you can really feel the enthusiasm for the possibilities on the horizon. There will be so much money in it, it's hard to imagine how this research was so stigmatized and uncommon a few years ago. Lifespan was a great book, definitely recommended!

[@joppadoni]

Can't wait to watch the follow up in 60 years time. As always, keep looking quadranguarly.. ;-)

[@thechairman74]

So from a superpower perspective, it can be explained that people who are immortal have the ability to rewrite their genetic code constantly to avoid aging.

[@macysondheim]

No.

[@user-ox1ur1ij4t]

Thank you ❤

[@ebt12]

This is the first time I am aware Neil DeGrasse Tyson has dealt with the subject of fighting aging, and it is wonderful to see. The idea aging can be brought under medical control is becoming more and more accepted amongst medical professionals, with the knowledge of why we age being better understood. I hope more people are brought on to the show to talk about it.

[@chrisblack9851]

Reminds me of the movie The Fountain when Huge Jackman said "death is a disease like a virus and there's a cure for it"

[@fwabble]

Huge Jackedman

[@EmpyreanLightASMR]

0:40 "my favorite stand-up comedian" RIP all other cohosts 😂 (but for real, this is the dream team, you all are amazing)

[@Stevestevestevestevestevesteve]

That wasn't funny at all. Was terrible like all of the jokes on this show

[@lorisfoucart2475]

Fantastic episode

[@matthewdimarcantonio4627]

Wow the details are eye opening

[@ThanosDestroyeryearsago]

I’ve been seeing stuff on longevity recently, really hope it happens soon.

[@jettmthebluedragon]

Are you hoping to your FOREVER suffering?😈beacuse I will give it to you as you may think being immortal is a good thing 😐but be careful what you wish for as their are fates worse then death 😑the problem is people like Neil don’t fully understand what it even means to be dead and even if they do they try to make money of it 😑

[@Carrix_]

Really hope it's not

[@Carrix_]

Although nothing wrong with longevity, but very long longevity and even immortality, I dont like

[@Str8RippinGaming]

oh you understand what it means to be dead? also uh no. they are not going out of their way making money off death what is this comment.@@jettmthebluedragon

[@teve90]

U speak ignorantly​@@jettmthebluedragon

[@Sammasambuddha]

I've seen things you people wouldn't believe. Funny thing. I wrote that quote before i saw Neil's copy of Bladerunner in the background. Subconscious sheet there!

[@Kim_Miller]

And Baty's closing line, "Time to die" is somewhat ironic considering the content of this discussion.

[@Sammasambuddha]

@Kim_Miller yes! That's what I was digging at, too. Wanting longevity vs. experiencing life. Also, "Time to die" was also Leon's last words.

[@MichaelDembinski]

This is StarTalk at its best. Relevant, informative, detailed - and hilarious. Thanks guys!

[@funghouls5498]

What a wonderful, enlightening discussion on Sinclair’s research

[@waynehedd]

Get Bryan Johnson on please!!!!

[@lazrus7049]

Thanks!

[@richardkrent5819]

I’m 70 and my goal is to live to at least 1,000! Now I’m thinking that is still too short! Please continue your research and share it with the world so we can learn more and experience more while exploring our universe! Thanks for all you do!

[@wanfuse]

what about: myeloablation and transplantation where patient receives stem cell transplant from a compatible donor (allogeneic transplant), has studies been done on patients with total myeloblation, whether they become young as the donor? surely this has been tested in patients with leukemia? I assume this would test the information theory?myeloablation" or "ablation," depending on the intensity of the regimen. Transplantation: After the conditioning regimen, the patient receives the stem cell transplant. The stem cells can be donated by a compatible donor (allogeneic transplant) (post a deep fasting period of 5 days?)

[@MythicosQc74]

1) Allogenic transplants are an incredibly hard procedure to go through, with a death rate at 2 years of 5-30%, depending on the exact type; 2) Long term survival of patients is often predicated on the transplant's ability to completely replace the receiver's original stem cells with the donor's. There's no guarantee it will succeeds, and it takes only one leukemic cell of the donor to have survived myeloablation to make the disease come back; 3) Only the stem BLOOD cells (the ones produced by the bone marrow resulting in the different blood cells (platelets-red blood cells-white blood cells)) are replaced; this won't change anything to the DNA or epigenetics of the receiver's other cells, i.e. there's no positive influence on the patient's long term survival (other than the fact that the procedure will potentially heal the cancer, of course).

[@wanfuse]

@@MythicosQc74 I was not suggesting it as a method for general use, but rather as a method of proof for the information theory, that is, does it result in a short term reversal, performing the procedure only on the person with leukemia that has no other alternative anyway. It has too many ethical considerations for general use, so am not suggesting it be used that way.

[@wanfuse]

@@MythicosQc74 ah I see not all blood cells are replaced.., is there a fundamental difference in these cells such that a replacement can not made? they both can be produced from stem cells, yes? no? or one transformed to other?

[@timtruett5184]

Leukemia is a terrible disease. I don't see how it could be a good place to look for hints about leaving a long time. Acute myeloid leukemia has a five year survival rate of about 20%, and that includes everyone who's been able to have a stem cell transplant. Look at the probability of survival curves for aml. You will be shocked. Survival is even worse for relapsed aml. Survival time for relapse might be three or four months. If you want a good problem to work on, find out how to eliminate leukemic stem cells. It is the one in a million leukemic stem cell, after treatment, even after treatment with a stem cell transplant, that causes relapse.

[@wanfuse]

@@timtruett5184 Experimental treatments have advanced medical science across various fatal illnesses, providing hope and potential pathways to cures. Beyond gene therapy for Canavan disease and hyper-personalized medicine, other notable efforts include: Experimental gene replacements for immune deficiencies Advanced cell therapy for certain types of cancer Innovative biologics for neurodegenerative diseases Groundbreaking antiviral drugs for viral infections Cutting-edge stem cell treatments for heart disease Each of these areas represents a frontier in the ongoing battle against life-threatening conditions, showcasing the power of science and innovation in pushing the boundaries of medicine. Things that were wrongly done without patient consent include ( wrongly I am adding for clarity--- so my position is not misrepresented) HeLa cell line, derived from Henrietta Lacks' cervical cancer cells in 1951 without her knowledge or consent. These cells have played a crucial role in medical research, leading to significant advancements, including the development of the polio vaccine and research into cancer and AIDS. Henrietta Lacks' story highlights important ethical issues in medical research, including consent and the rights of patients.

[@techgayi]

audio is a bit iffy for this talk, did anyone feel it ?

[@karlgoebeler1500]

Question. Caterpillar metamorphosis. Restarting the Hox cell body plan and starting the cell different ion process?

[@GoldyMcGoldface]

This was a great episode. David is so affable and everyone is just having a great time talking about some great science.

[@TheMaestromMephisto]

There will be a time when life expectancy would be 150 years, right now average is around 70ish years, see the way we are shocked our ancestors lived only 35 years, our future generation would be shocked how we used to have a low 70 years expectancy

[@graylienz]

That would be cool.

[@Theanalyst-pz1ui]

I think it will be 250 to 300 years old.

[@comradecapybara]

where are you basing this? in most developed nations its around 80 right not

[@eeriemyxi]

My 3-month-old son is now TWICE as big as when he was born. He's on track to weigh 7.5 trillion pounds by age 10

[@dwaynesmith5341]

By observation of the 'immortal' jellyfish, or Turritopsis couldn’t we figure out how to trigger this in humans? They rewrite/reprogram the identity of its own cells, returning it to an earlier stage of life.

[@dwaynesmith5341]

The human genome has 3,300+ billion lines of code but with the help of modern technology we would be able to pin point and reprogram what we we want. This could hypothetically either cure cancer or make super cancer depending on success.

[@alex84621]

Its super simple. But we need the teck and processing power to do it. 2027 AI is self aware. Easy done then.😊

[@joshlocher71]

@@dwaynesmith5341 so have you heard about David sinclair's chemical cocktail that can be made into a pill because I sure have

[@marcog6470]

Quite sure the work has been done on the subject already, it will be a guarded secret for the elites only.

[@jasonta12]

I definitely remember hearing about epigenetic changes being passed down by survivors of the Holocaust. Definitely something very interesting to think about in regards to how our bodies react to the world

[@maniacslap1623]

When u think about it, is it really that surprising that Mother Nature could affect us relatively quickly when we can do the same to it?

[@tommycollier9172]

Very interesting episode Neil Thanks for sharing

[@geoffreyrhine8210]

Question - as you applied this therapy to extend the life of the mouse called Dorian, did its picture get older and turn Gray?

[@KV-lj6el]

There are some pictures of mice that have undergone therapy in some of the interviews with Sinclair, look for it.

[@jessejorgensen3931]

Extending life is the only thing that will ever get us off this rock

[@Jay-eb7ik]

yes, let's explore the endless universe. so much to see and discover.

[@matthewcardenas5124]

I am a year away in a biomedical science bachelor due to this topic and I’ve been obsessed with this since I was a kid

[@BobLinton]

Thank you very much.

[@Yamaprilia]

There is an exception already in nature. Its the eternal jelly fish. It can restart its ageing process if it gets damaged or unwell. Please check it out

[@canobenitez]

dman! imagine forgetting you age

[@HulkSmash512]

I love how Neil gets defensive over Chuck like no no we need him here 😂 He wasn't letting that slide haha

[@floior89]

Wonderful, interesting, thought provoking and educating! It's a wonderful channel with a wonderful host and wonderful participants.

[@atfaxxx]

Love to soak in the knowledge they talking about and chuck just makes it fun 😂

[@pundah7084]

I don't like the idea of living forever but extending our lifespan sounds amazing. Imagine if we could double our lifespan.

[@HaggisDruid]

Yeah, just gimme a few hundred years at least.

[@firstlast6226]

​@@HaggisDruid300 should be the max imo

[@NicosoftNT]

@@firstlast6226 We just don't know, if you have the eenergy to constantly explore and develop yourself with youth's passion, WHO knows what a 300 years old version of you would think? What technologies would you experience? NO WAY. If you met your 300 year old self, you will not recognise you as your future self claims 300 years is not nearly enough 🤷‍♂

[@Jay-eb7ik]

@@firstlast6226 speak for yourself. I want 50,000 easy

[@alswedgin9274]

5:50 Damn, Chuck..dropping a bomb question

[@lleston8927]

Amazing content! Keep it coming! I would like to live until there is no point on living. I mean until I lose the spark that keeps me going.

[@sarahalbert6833]

Neil, Gary, Chuck. Love your channel. It is a science fiction writer’s dream & great research resource 🤩

[@xavierowino]

Wait a minute...pls clear up the confusion. People think sinclair conned his way through with data that can't be replicated for some studies he did before...

[@aitarun]

sometimes i feel Chuck chose wrong profession, he could be a great biologist, scientist or philosopher. I like his comedy but he can have many avatars

[@calvingoh9321]

Love the energy.

[@williammankel376]

I appreciate the update on the aging research and would like to know what books and journals to read to more fully understand this field

[@carl7674]

With all due respect... I'll believe it when I see it.

[@Izakokomarixyz]

next year, stay tuned…

[@carl7674]

@@Izakokomarixyz Don't hold your breath...

[@Izakokomarixyz]

@@carl7674 - You don’t believe why?

[@carl7674]

@Izakokomarixyz The study is too controversial among St Clair's peers and he is not addressing the criticism. There is insufficient independent repeatibility of his results. Glaucoma is not necessarily caused by aging.

[@hanstubben]

Max Verstappen, the F1 driver, is a prime example of epigenetic heritage. His mom was a kart racer and his dad was a F1 racer. At 17 years old Max got in F1 and now at 26 he´s a three times world champion.

[@NuntiusLegis]

Or he just picked up some tricks early on.

[@haydenjones5470]

Maybe, but that’s not necessarily a solid claim because you could argue that both his parents had some genetic trait (like quick reflexes, for example) that allowed them both to be successful drivers, and then that Max just inherited those same genes which also allowed him to be a good driver

[@abstract5249]

@@haydenjones5470 Max also inherited a culture of race driving as both his parents were race drivers. No doubt such exposure helped influence him to go into the profession.

[@user-jx9wy1ly7g]

@@haydenjones5470 to call Jos Verstappen a succesful driver is very debatable :P

[@omittapir5986]

Do glad to see Dr Sinclair after a loooonnnng break!

[@Avi-gk2my]

this is Beautiful❤

[@hopper2716]

is it me or has Sinclair's looks changed... this almost looks like a different guy but in a weird way, not in a younger way...

[@GrandpaCl]

plastic surgery

[@nightstalker9792]

yeah his face shape is like different from the last time on joe rogan, right? I need to check and compare

[@richardrolson2713]

I was thinking its his own avatar? Like maybe a Apple Vision Pro

[@djp2k9]

Looks like botox to me

[@chrisbusby4395]

Darker hair dye?

[@haudace]

Aging is what I call a self correcting problem of life

[@tomwirt319]

😊

[@JonathanTBE]

The correct term is natural selection

[@OM4Rx]

We love you guys from South Texas!❤

[@SARVX_]

Informative...🌱

[@Elzelgator]

Chuck is a really funny dude. He is getting smarter too...

[@chuckzilla3000]

So telomeres are basically a chromosome’s fuse. Fuse runs out, chromosome kinda goes boom.

[@Kim_Miller]

Think of them more like your car's front and rear bumpers. Each time you are bumped in traffic a little bit gets scraped. Sooner or later they will offer no protection to the real body of the car.

[@thechairman74]

Superpowered immortals might have the ability to constantly repair their telomeres, preventing aging, or at least slowing it down considerably.

[@jayelder9725]

Harvard labs is the Napa Auto parts of fuses😂. So true. Amazing !

[@craigstiferbig]

A methylation panel or screening will tell you what you need to supplement and what to chill out on or discontinue completely

[@masongovender9231]

Chunk is really the Master of this show, not to mention how well read and prepared he usually is.

[@axel_r_]

David Sinclair is one of the pioneers of longevity and the future humans are now creating. Question David! Be sceptical! Find evidence he is wrong! All of these are good things because if you prove what is wrong, you can narrow down to what is likely "right". But never call David a charlatan. That is simply ignorance. David has a proven knowledge of longevity on so many levels, and there is a reason he is on the show of Neil, who also has a lifetime of proven accomplishments while the wolves in the comment field here scream "CHARLATAN". You remind me of the people back in the day who screamed "BURN THE WITCH".

[@polashpegu2509]

In a video in dr Brad strandfield he is saying that David is a fraud who is greedy for money nd all etc...And that most of all of his experiments are false or something.. Is that true???? I'm in a dillema now cuz David was a role model for me... Reply

[@mintsprig7]

This is so interesting! Great stuff.

[@cryptopapi4737]

@Drberg I think could be a great guest regarding health, the keto diet, fasting, and autophagy.

[@therealleijames]

Yes

[@ctakitimu]

Would I want to live forever? No, you can only do everything so many times before boredom would set in. This is why heaven would suck after a few trillion years! However, I wouldn't mind a few thousand years. *edit* This all sounds great, but it'll only be accessible for the elites. Us worker bees won't get to have the longer lives. I know this because I know humanity.

[@alwayslearning8365]

The FDA and the medical establishment has to recognize and accept aging as a disease. Once it is officially accepted as a disease it will open up aging to a huge amount of research.

[@an0mndr]

I don't think defining it as a disease will change much. I think the only reason we still don't call it a disease is because it's something that happens to everyone and that we currently cannot effectively fight. The only thing calling it a disease might accomplish is encouraging a few more people to work on fighting it, but most of the people smart enough to work on that research already know it doesn't matter if you call it a disease or not so they're already working in it.

[@afiadawn]

this was mind-blowing. so incredible. how is this not front page news?

[@never_give_up90]

Cause it's not as great as they make it sound. We found a way to support health to live longer ... We've been doing it more and more slowly, but it doesn't make us live forever. So noone cares.

[@tatotato85]

cool stuff, im gonna rewatch it in 70 years to see how it holds up

[@deucedaprodeuca]

It is said that the first person to live forever, is already alive.

[@patludwig1971]

Yeah I'm right here. Hi!

[@chrisangel5020]

Well, it was also said we won't break the sound barrier. We will never tap the nuclear power. We will have ships with railway tracks to go in and out of water onto the land seamlessly. There will be a moonbase by 1980 or similar. And countless more predictions and quotes. So let's just relax and let things play out.

[@VermontJayson]

I hope it’s me

[@cheapskatepanic]

Not it!

[@graceokia8024]

How old is the person?