Glycerol-Phosphate Shuttle | NADH, Electron Transport Chain and ATP Yield

[@victoirelacaille3009]

hey, i wanted to thank you for all your videos. I'm a pharmacy student and it really helps me understanding biochemistry!!! love you

[@anna-eq4kx]

thank you! after a mental breakdown and lots of crying, I decided to watch some KZbin videos for better understanding and this was very helpful, thank you!!!

[@jaimekelleher598]

Omg. Thank you. Thank you. Thank you. I have had this surface-level understanding that NADH from glycolysis vs. from the TCA cycle are different in terms of ATP production, but I've never been able to understand it. Until now! Again, THANK YOU!

[@jjmedicine]

Hi Jaime! I'm so glad you found it helpful :)

[@alara1428]

thank you for the video! I am a vet student and you have helped me so much with biochem. Thank you!!

[@kal7708]

This video is so helpful! Love the visuals and explanations.

[@Tom-pd8jd]

Nice video. A couple of suggestions for you. The NADH does not offer 2 protons for transfer to the dehydrogenase protein. Technically it is one hydride (H-) and one proton (H+); protons don't have electrons ;). Secondly, the ubiquinone is not a protein. It is a rather large organic molecule with an aromatic ring (the quinone moiety) with a rather substantial nonpolar tail (series of isoprenoid units). This permits its movement through the nonpolar region of the lipid bilayer.

[@claykurisaki9758]

You stated that NADH produced in glycolysis only produces 1.5 ATP since it's converted to FADH2 to get into the mitochondria via Glycerol Shuttle. If it enters the mitochondria via the Malate Shuttle instead, it will produce NADH which can enter Complex 1 and be worth 2.5 ATP. How do you determine whether the NADH produced in glycolysis enters the mitochondria through the Glycerol 3 Phosphate Shuttle vs. the Malate Shuttle?

[@harold1009]

Thank you this was very helpful

[@해피조이-w2w]

This is brilliant. Thank you so much

[@jjmedicine]

You're very welcome!

[@코초초초-c3k]

저도 서칭하다가 여기까지 왔는데 모국인 만나서 반갑네요

[@safiabibi4450]

Thanku for complete guidance.

[@TimeSculptors0]

Thankful ❤️❤️❤️❤️❤️❤️

[@stumbleboy1257]

I really liked ur video very much Thank you so much for posting it But i had one question By which type of chemical bond is the phosphate group linked to glycerol-3-phosphate

[@rocioguarniz5186]

Very helpful!!!! Thank you!!!!!!!!!!!!!!

[@thafseenak1447]

Spr cls👌🏻👏🏻

[@prabhasingh5064]

Thank you so much sir.

[@haninamer4288]

thank you

[@JaLLaM86]

Does anyone know how G3P may pass the outer mitochondrial membrane? I don't think it is specified in the video

[@ruchijayaswal8914]

Very nice video . Thankyou sooo much

[@IMChessMD]

From my understanding, the outer mitochondrial membrane is similarly permeable (to the cell membrane). That is why people usually do not mention this point.

[@Tom-pd8jd]

The outer membrane is studded with porin, which allows molecules up to 10KDa to pass into the inner membrane space.

[@assalal.mehemdi4408]

How do I calculate the energy produced by the oxidation of one glucose through the glycerol phosphate shuttle?

[@0623134]

The glycerol phosphate shuttle is only for NADH produced in the cytoplasm while oxidizing glucose. For glucose only 2 NADH is produced during glycolysis in the cytoplasm. Going off of the video 2 NADH in the cytoplasm gets converted into 2 FADH2 in the electron transport chain. 2 FADH2 oxidized to FAD gives you 12 H+ ions pumped across the membrane. 12 divided by 4 gives you 3 ATP produced by ATP synthase. An easy way to memorize this is NADH produced in the cytoplasm yields 1.5 ATP within the electron transport chain.

[@aneta.m395]

Why do the complexes I and III pump 4 H+ each, and the complex IV pumps only 2 H+?

[@Fun_Dips]

He is incorrect. Complex I pumps out 4 H+, III pumps out 2 H+, and IV pumps out 4 H+. He also messed up the pathway in which the electrons travel... smh

[@Fun_Dips]

Also, he incorrectly represented glycolysis as occurring in the mitochondrial intermembrane space, when it occurs in the cytoplasm... This whole presentation is a mess

[@rafiaimranbts8369]

Cuz only 2H+ pumped by complex IV are needed to form two water molecules

[@naushadkhan5378]

He is correct. So Complex 4 pumps only 2 protons to intermembrane space because it uses 2 out of 4 electrons from mitochondrial matrix to convert oxygen into water. So 2 protons from matrix+ 2 electrons from ETS and one oxygen molecule combine to give 1water. Rest of the two electrons are pumped to intermembrane space by Complex 4.

[@SP-eg3rn]

thanks

[@oguzhandasdemir]

3:50 .... protein known as ubiquinone ?

[@jjmedicine]

Sorry, I misspoke here. Ubiquinone is not a protein.

[@oguzhandasdemir]

@@jjmedicine Thank you. Your videos are so instructive. More lesson please 😊

[@baenmarq]

AP bio test in 30 minutes 😎

[@freshob]

you should take this video down and do it over with more accuracy

[@grumpybottle1378]

Thank you for not being indian

[@fannyalbi9040]

what is that mean?

[@ghassanauf8103]

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