Journal Club: Exploring Immune Response to Diet: Vegan vs Ketogenic | The Metabolic Link Ep. 38

In this episode of The Metabolic Link, Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff dive into a fascinating new paper that compares the metabolic and immune impacts of ketogenic and vegan diets in humans.
The study, titled “Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans” takes a deep dive into the multi-omic effects of these two very different dietary approaches. The researchers found that just two weeks on a ketogenic diet significantly enhanced markers of adaptive immunity, while the vegan diet was associated with increased innate immune function.
The hosts unpack these findings, discussing the potential mechanisms behind the divergent immune signatures, the limitations of the short-term study design, and the need for further research.
They also highlight the importance of carefully standardizing the macronutrient and micronutrient compositions of the dietary interventions to isolate the key drivers of the observed changes.
Overall, this episode provides a thought-provoking look at the profound impacts that diet can have on the functioning of our immune system, setting the stage for future studies exploring the therapeutic potential of nutritional approaches.
This episode is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.
Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at gdx.net/themetaboliclink
As mentioned in the introduction, you can watch this free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health: • Metabolic Health Revol...
In every episode of The Metabolic Link, we’ll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!
You can find us on all your major podcast players here:
Apple: podcasts.apple.com/us/podcast...
Spotify: open.spotify.com/episode/61pj...
Amazon Music: music.amazon.com/podcasts/78f...
Buzzsprout: www.buzzsprout.com/2103269/14...
*Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have."

[@mariejones7136]

I was vegan forever and got non Hodgkin's cancer..i juiced veggies most days .. now im doing keto to have ketones and low glucose..But did i get a curable cancer due to being vegan or did i eat too many carbs eating vegan. ?im 70 so im excercising and working on my mitochondria too..I feel better though eating keto ..ive added pasture raised grass finished meat and fish and eggs..i fast 48 hours a week and intermittent fasting everyday..

[@MetabolicHealthSummit]

Wow, thanks for sharing!

[@paulettestancil5986]

@marijones7136 thanks for sharing Diagnosed Non Hodgkin’s Lymphoma WM Waldenstrom Macroglobulinemia 2011-12. Keto way of eating since 2018 saw small decrease in IGM blood numbers. 2022 prescribed zanubrutinib seeing constant decrease IGM numbers. March 2023 through March 2024 eating more keto- carnivore. 3/23-3/24 gradual weight loss of 31 lbs btw September 2023 added 72 hrs sardine challenge weekly. WM is a stubborn blood cancer 🤦🏽‍♀️

[@markfuller3808]

Thank you for this summit. I am watching the dawn of a new day. 🙏

[@MetabolicHealthSummit]

We're glad you enjoyed the discussion!

[@bert_buikema]

I have been eating an animal based ketogenic diet for over two years, and I haven't been ill and haven't even had a cold or flu for over two years. I did lose 30 lbs and gain a lot of energy. Besides that I believe that a diet study that only lasts two weeks per diet is way too short and basically useless.

[@jamespatrick5348]

I wonder about the benefits of a keto-vegan diet where protein is found in soy, nuts, pea protein, etc. The usual non-starchy vegetables along with hemp seed, flax, chia, etc.

[@LisaMaghrak]

Read Dr Natasha Campbell's book titled Vegetarianism Explained. She explains the difference between animal proteins/fats and plant proteins/fats and how they are utilized by the body

[@kathya1956]

One of your videos convinced me to try allulose. What a disaster. Had huge depression. Not one to suffer of it normally. Last time I had it was when I had Covid.

[@MetabolicHealthSummit]

Oh no, we're so sorry to hear you had that experience. We hope you feel better!

[@mariejones7136]

I love allulose..Tastes like the best sugar substitute.

[@ricksikora7270]

I love it and it lowers my blood sugar.

[@LisaMaghrak]

​@@mariejones7136agree 100%

[@marcusmatthews8255]

Too much sales talk at start. Please work it in the middle of your video instead at start, more like Dr Huberman