G-Protein Coupled Receptors (GPCRs) - Biochemistry | Lecturio

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This video “G-Protein Coupled Receptors (GPCRs)” is part of the Lecturio course “Biochemistry” ► WATCH the complete course on lectur.io/gprot...
► LEARN ABOUT:
- G-Protein Coupled Receptors
- GPCRs and G-Proteins
- β-adrenergic receptor signaling - Creation of the second messenger
► THE PROF: Kevin Ahern received his B.S. and M.S. degrees from Oklahoma State University, and a Ph.D. in Biochemistry from Oregon State University. Currently he is working as professor of biochemistry and biophysics at Oregon State University. He is also a co-author of the popular biochemistry textbooks, “Biochemistry Free and Easy”.
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[@sarayaghooti4850]

Finally understood this hard lesson...

[@lecturiomedical]

We're really happy to read this! If you wanna watch the complete course, start your Free Trial now: lectur.io/gproteinreceptors

[@margob979]

Love your explanation manner. So clear. Very pleasant voice as well

[@leevewilliams2199]

Brilliant explanation-thank you so much

[@00sunnyshine]

Very well explained!

[@MDISLAM-qw7ic]

I have found after long time a great video..owesome lecture

[@samashanak]

Thank you

[@eddyjay5783]

Best ever explanation ! Thank you.

[@ehllarpearl]

Thanks! Great explanation!

[@tahminefarahmand6294]

WOW! Perfect, thanks a lot!

[@jalehnikfarjam9844]

Awsome. Thank you!

[@mohamedelhag5286]

Thank you so much

[@davidrose555]

Excellent. fun. go go go. Thankyou

[@maazullah5052]

Long live

[@ciscobriano]

Can someone pleaseeeee make a video of GPCR next to or how the Cannanoid System dwarfs the GPCR. Pleaseeee!

[@AsherBrandt]

Perhaps I can help you. Send me a message.

[@D_Frames]

Can someone explain about the Gs Gi Gq and Gt actions of alpha subunit

[@DominkxD]

Ga exists in up to 16 isoforms, grouped into 4 subgroups. a(s), a(i), a(q) and a(12/13). If the receptor activates a G-Protein, that has an a(s) subunit, this subunit can activate membranebound adenylate cyclase, which produces cAMP. this is is a second messenger activating PKA. PKA is a serine/threonine-kinase, which phosphorylates different proteins and therefore activates other cascades. An a(i) subunit inhibits the the adenylate cyclase, which results in low cAMP levels and no activation of PKA. a(q) subunits activate phospholipase C. This enzyme can divide PIP2, a subtance in the cellmembrane into IP3 and DAG. the DAG is left in the membrane, the IP3 binds to calcium channels of intracellular calcium depots (e.g the ER). calcium concentration rises. Another enzyme called PKC binds to the DAG in the membrane. It also needs the calcium for activation. With both, DAG and Ca avaible, it acts as a serine/threonine kinase and can phosphorylate other protein, which results in activation of other steps. the a(t) subunit is a special form of an a(i) subunit. it is mostly expressed in rod cells of the retina (T stands for transducin, a synonyme for this kind of g-protein). The most information is from Syrovatkina et al., 2016, doi.org/10.1016/j.jmb.2016.08.002 hope it helps you

[@D_Frames]

@@DominkxD Thankyou so much! I thought no one would even respond to this. It helped me a lot. Thanks again Dominik Freund!😁

[@DominkxD]

@@D_Frames you're welcome :)

[@sonyramzy8611]

👍👍👍👍👍

[@yourfuturedocburenbeiya]

Awesome explanation; thank you so much sir!

[@asmay.7245]

OMG ! Thank you so much !!