Receptors: Signal Transduction and Phosphorylation Cascade

[@simontamang3076]

Best explanation someone has every given to me about cell signal...Thank you so much professor dave

[@adamh.8823]

This stuff is too amazing. Does this not just blow peoples brains out of their heads?

[@ProfessorDaveExplains]

that's how i feel about it!

[@khalidsheikh4699]

Truly Mind Blowing! Thanks a Zillion!!

[@maeganjames2490]

Adam H. It sucks when you have to memorize it for a final

[@katelynns4887]

Hm now that you put it that way, yeah!

[@aniviaswag1394]

Adam H. nah bro i hate this biology class

[@jmakinson]

Thanks a heap! The entire first chapter in my Pharmacology text suddenly makes sense. Your video was the first domino and I am very appreciative. Keep up the great work.

[@wfox6985]

Bro - your lecture was so good and helped so much. I am taking a psychopathopharmacology class and your lecture was a game changer for me. So basically, psychoactive drugs are just ligands that we hope illicit a favorable response. Would you say that is a correct way to look at it? Thanks!

[@excel77115]

What a great help you are! You make the best videos for me! Visuals, language, in-depth enough explanations of the chemistry side as well, which helps with my understanding. There are many people out there making videos, but for me you're the best! :)

[@liabduhliabduh2207]

Superb it couldn't be anymore better than this.

[@brightbindim4907]

The tutorial is so helpful and easy to understand

[@Avatarlifeplays]

Thank you, Professsor Dave! I have learned a lot from watching your video. I am also a visual learner, so this was super useful, and I took notes as a listened and followed along.

[@dkerrtty1220]

Thank you because I was doing some AP Biology learning (12th grader) and I was completely not understanding how phosphorylation was working.

[@dkerrtty1220]

Now that I think about it, watching your channel could allow me to do well in college with my science classes

[@ProfessorDaveExplains]

yeah yeah watch them all! i've got a lot of different stuff.

[@abhinavbachu5309]

Thank you so much for this video!!! It really helped me out a ton!!!

[@rdelong1210]

Keep making these videos! They're so much help trying to put together this information. You make it actually make sense!!

[@teentony2181]

Incredibly helpful, especially for visual learners!

[@midzymango4679]

really saved my apbio grade thank u!!

[@adsilv7913]

Please make a video on Ras Pathway

[@davidrosen5137]

This was great! Very helpful!

[@lyndapope7796]

This video has helped solidify such a complex process thanks heaps

[@adamglustein8700]

Thanks a lot for these videos, hands down the best explanations of all things science on KZbin. This video helped me a lot with my project on receptor related diseases (Grave's disease, hypercholesterolemia and the role of serotonin receptor malfunction in depression). Truly a lifesaver!

[@SCIPROlearning]

Excellent presentation

[@mariamklibadze]

omg thanks a lot I couldn't get it before I watched it

[@hajiqasim448]

Simple explanation in you tube. thank you Dave

[@FredsonTorres]

Hi Professor Dave how are you doing? I am also a teacher (in Brazil) and I am thinking about doing something like your channel in portuguese. You are very inspiring! By the way, I got curious: what is your major? To which courses you give lectures to? Pharmacist guy here (Organic Chemistry PhD in progress here). Hugs from São Paulo, Brasil!

[@ProfessorDaveExplains]

thanks for watching! i studied organic chemistry and that's what i used to lecture on, if you look up my organic chemistry tutorials those are the first things i created, and they are essentially just the lectures i used to give in class. good luck creating your own content!

[@Drfocus123]

you are a great professor in organic chemistry thanks professor dave for all

[@mitsunori222000]

Wish I'd discovered this before. Great channel, great explanations.

[@sepsinareski889]

thank for u explain.. can u explain about fatty acid signaling by GPR120 and GPR40? and how about lipid sensing mechanism.. ?

[@hama8027]

Thank you for this wonderful explanation

[@Acts--wn9zq]

What an amazing design!

[@bangnikabang6501]

Thanks

[@anirbanmaitra6051]

Very detailed! Thanks a ton

[@lottiehara3491]

Well explained

[@harisivanesh942]

Super work professor

[@tismon112]

You switched the "I's" between "ligand" and "diffuse"

[@darweeshhd5841]

I like this guy , very clearly explaining ....

[@Zetsuke4]

Very nice! I really like your style

[@bohanxu6125]

3:04 I think such standard explanation of Phosphorylation cascade can be misleading. The Phosphorylation kinase are not "exchanging" Phosphate group, the activated Phosphorylation kinase would make APT to give up extra Phosphate group to yet-to-be-activated Phosphorylation kinase. The power of cascade is the chain reaction that amplify a signal from one Phosphorylation kinase to a huge amount of Phosphorylation kinase that can eventually bind with a lot of other proteins for some large scale cellular response. This amplification is a very non-trivial process. Typically you would image a few molecules can only cause a few reaction. However, a cascade is need for situation like how a camera can capture one photon and amplify it to a macroscopic effect like pixel changes on ones detector. (also like how g-protein can amplify a signal) By the way, I love Professor Dave's videos overall. They are very good. Also I can be wrong about Phosphorylation cascade. Biochemistry is not my field.

[@jellykin7161]

Slight correction at 2:00 G protein coupled receptors already have a G protein before activation.

[@anirudhsharma1706]

No its not true ig Can you share any link to proof .

[@muntahausman1744]

Thank you so much sir for this explanation!

[@BenjaminDeutsch-xd1yh]

Agreed, Best explanation

[@shuqingyang6577]

I found it super useful!

[@turboallen]

Fantastic video!

[@gaganpreetsingh6238]

Omg professor Dave thank you.... this video made me understand so muck more better than my book and Professor.

[@asmajaved424]

Thank you so much.This was really helpful.Really appreciate your hard work.❤❤

[@soominlee376]

Thanks a lot !

[@gogomoh5909]

Thanks a lot 💓

[@viswaneedevisunnasee1878]

Amazing👏👏👏 Simple and beautifully explained. Thank you so much.

[@kaitlyndunn4571]

Thank you Dr. Dave🥸👏👏👏

[@kaustavbhattacharyya2217]

What is noise in signal transduction? Please explain me in detail.

[@erickcruz2576]

Thank you Dave.

[@noel5544]

thank you professor dave

[@priyadarshanishendage698]

It is nice video sir thank you so much ....😍from india

[@PoojaSaini-cz5fu]

Thank you sir

[@insight4052]

Helpful 🎉

[@ALIKHAN-ge4cj]

thanks Pro.

[@alimamstudying9462]

Thank you

[@shinn-tyanwu4155]

Outstanding

[@Denise00700]

Very understandable! Thank you

[@asox5229]

Super helpful 🙏🙏 Thank you so much Professor Dave!

[@btchhangte4481]

Please explain Protein kinase receptor

[@krishnamurthy1086]

best teacher.

[@jenroberts7267]

Thanks Professor Dave! Ps. I like the intro: "He knows a lot about the science stuff..." My sense of humour with all the facial expressions too. Haha!

[@THUBBNC]

Awesome！

[@curranadvani9725]

Professor Dave>>anyone else

[@aeiiea]

Superb

[@himaniy6013]

Thnx alot...from🇮🇳

[@negar1370]

thanks a lot

[@louispasteur5053]

Thanxxxx

[@jacksonharms8007]

You are the goat man

[@parfoisbaker]

Thank you!!!

[@sphiwekaluwa8720]

Thanks sir so helpful

[@herbertlaraordaz2136]

Thanks, I enjoyed much.

[@Jamez006]

Awesome!

[@TBCS3000]

Can anyone know a movie about biology that you recommend?

[@bangnikabang6501]

awesome, thanks !

[@naoh22000]

3:15 Are all ligand-receptor complexes absorbed into the cell?　Or is it a rare case?

[@ProfessorDaveExplains]

No, not always.

[@naoh22000]

@@ProfessorDaveExplains Thank you very much!

[@stevereyes861]

Thank you, you have explained it so well

[@jagadishvemula2304]

TQ bro

[@jasminehasan7084]

I LOVE YOU SO MUCH

[@Mina-Rofaeil]

Perfect

[@goodsir2551]

Thanks for all the helpful videos and for being so awesome Professor Dave. Why are you so awesome though? It's simply not possible to be so awesome as you are. Are you an alien or something?

[@ProfessorDaveExplains]

i've been practicing the art of awesome for many years, young padawan!

[@adamh.8823]

Avoiding the real question I see... you are fooling no one.

[@lilianignatius]

My thoughts exactly. You deserve more. Thanks Professor Dave!

[@abdullahhelal5413]

Nice!

[@tahirtantary7438]

Nice bro

[@oliviadittmar9719]

Thank you!!!!!!!

[@muvafakiyefilanfalanhanm1412]

you are jesus himself.. ur saving all of us god bless

[@SCIPROlearning]

👍 great

[@ihanba]

Your delivery is grating, but this video was very informative and helpful. Thank you.

[@rouleit5131]

I worship you

[@shandrajones6462]

Anybody here before the 2020 AP biology exam? 💀

[@54blueroses]

in summary 05:16

[@Girlnamedanne]

Does it frustrate the bajeebus out of you that profs of major unis are using your teachings in place of them lecturing? And yet, they get paid. I'm mad for you, but happy for me...because my brain receptors are finally understanding this stuff. Thank you.

[@ProfessorDaveExplains]

but i get paid too! not very much right now, but in a couple years when the channel is bigger i'll be making much more than those teachers, and in completely passive income. so to the teachers who use my content, whether appropriately or not, i thank you!

[@Girlnamedanne]

As a nursing student, toddler mom, and one whose dog is currently challenging my rent amount in the hospital for canine pancreatitis, it is a laughable amount, but please accept my meager monthly dolla-dolla bill toss into your guitar case, good sir. If there was a "Professor Dave pretends to be you and takes your exams for you" option, I'd probably figure out a way to make that happen, academic dishonesty aside. :)

[@ProfessorDaveExplains]

woohoo thank you! every dollar counts!

[@83rickyspanish51]

Anne Marie Miller I would have to say that it makes money for the universities and schools to keep the students coming back day after day instead of just comprising creating a way to just explain it cleverly and in an understandable form as this medicine all about money keep them coming back

[@Avatarlifeplays]

2:42

[@trejosworld]

What

[@joymutheu7737]

❤❤

[@dimaabuelainain7670]

I liked the explanation but I don't like that you are reading from somewhere!! this makes me confused 😫😫

[@ProfessorDaveExplains]

You want to just improvise this information? That’s weird.

[@karebthedog]

You're awesome. But maybe, like move your arms around and loosen up a little bit? Sorry the content is great but it just looks a bit awkward haha

[@kristineofori1331]

When you close your eyes and listen he sounds like the guy from crash course :D

[@bera9919]

tıp için çok yüzeysel, beğenmedim

[@patrickbush2531]

his intro doesn’t match with his video personality

[@ProfessorDaveExplains]

Says you.

[@moemedimbakibazanisi224]

Thank you

[@crystalstob3740]

So helpful! Thank you!

[@walarajab3052]

Thanks

[@bera9919]

tıp için çok yüzeysel, beğenmedim