G-protein coupled receptors (GPCRs)

G-protein coupled receptors (GPCRs) are an attractive drug target; however, not enough is known about their structure, as they are too unstable to isolate and purify. This medical animation highlights the important role they play in many physiological functions and diseases.
Hosted on the homepage of the Heptares website, the animation introduces a new method developed by Heptares, of maintaining the structure of GPCRs following their isolation. This method allows for the more effective assessment of drug candidates, highlighting how this technology may be used to develop new treatments for various diseases, including Alzheimer’s disease and cancer.

[@christianverkerk6185]

Why is this the clearest animation ive ever seen

[@l.square1415]

The best, most beautiful medical animation I've ever seen! Marvelous~

[@atheeralabdy5381]

the nicest medical animation that ever seen, good job

[@LaikaBuzz]

This just blew my mind. The future is going to have some interesting drugs to aid the body in fighting diseases.

Nice animation. Marketing material. Too bad it did not go further as to explain the mechanism.

[@kark1086]

why is this animation better than Dr Who episodes?

[@joanmcdevitt7998]

THE LIGHTNING LOLOL

[@samirjamil3324]

Hahaha

[@tylerbradley8124]

Action potential

[@samirjamil3324]

@@tylerbradley8124 it's not a nerve.

[@tylerbradley8124]

@@samirjamil3324 they showed the synaptic cleft right before

[@tylerbradley8124]

which have GPCRs (metabotropic)

[@soearkarhtet2122]

That's a really great animation.

[@Pandit9763233]

the GPCR animation is best

[@childeuwu7650]

Is this youtube premium ? 😲

[@MDISLAM-qw7ic]

Excellent animation

[@slcstengel]

This is incredible.

[@arock8586]

Wonderful animation

[@SPX3455]

Do inverse agonists cause the opposite biological cell function to be activated compared to antagonists? Or do they rather cause a more pronounced neutralization of the receptor?

[@nishantsen6820]

They have affinity but negative intrinsic activity dose response curve will help in uñderstanding

[@midhunkmadhu8929]

Antagonists are the molecules that prevent the activity of agonists. But there can be a basal activity of the receptor in the absence of an agonist too. Inverse agonists actually stop the basal activity and make the receptor totally inactive.

[@brownliberace8703]

wtf this is genuinely a beautiful animation, do you know who directed this??

[@femifathimaibrahim4074]

Thank you so much 😭😭😭 u helped me 😭😭

[@drdavidstr]

what is the background music pls

[@alseddiqalnehari3438]

تريد ان تطلب الله عليك بالترجمة فانها مفيدة ورئعة

[@sefatullahzakary6936]

That is great.

[@mohanarangan.r9567]

so useful

[@hungrylemonpanda245]

very psychedelic love it

[@arpitparmar1203]

🙏🏻

[@sathishkumarpampana3431]

Supb

[@alseddiqalnehari3438]

Please translate into Arabic

[@AmruMagdy]

اللله7