I finished all 3 videos of lipid transport and I have to say, it made my life way way easier. Thank you!!!
@aryanahassar52953 жыл бұрын
When VLDL --> IDL --> LDL I made a rhyme that goes "VLDL has all 3, IDL was lost at sea , and LDL has lost its E" to remember which one has which receptors. VLDL - Apo B100, C-II and E (has all 3) IDL- Apo B100, E (lost at sea = lost the C-II) LDL - Apo B100 (lost the E) Maybe that will help someone haha
@manel59472 жыл бұрын
thank you
@yes78552 жыл бұрын
lovely! thanks :D
@doctorhamzatanveer28724 жыл бұрын
Dirty you deserve 1 million subscribers
@thirstycrow102 жыл бұрын
I think way more than 1 million within a year… very nice effort, very nice way of teaching and simplifying complicated topics… excellent job 💐💐👏🏼👏🏼👏🏼
@dinayounis64732 жыл бұрын
i think he desreves more.. he makes everything supersimple
@thato443410 ай бұрын
4 years later and this video is still the best! Thank you so much!
@muneebtakesmedicine2 жыл бұрын
Step 1 in 2 weeks and I was freaking out because I think I have forgotten most of the stuff I have been learning... bing-watching your videos these days and it just give a sense of 'calm' and ofcourse, they are making eveything super easy... THANK YOU for existing
@fjaramillo887 Жыл бұрын
How did you do, any tips?
@PZooni8 ай бұрын
Hey! Do you have an update?
@lisliswanttosleepallday144 жыл бұрын
I’m a medical student from Thailand . Thank you for your hard work!! ❤️❤️❤️❤️
@eduardoandrade90654 жыл бұрын
Didactics includes knowing a lot about the subject, understanding what the target audience needs to know and, mainly, knowing how to explain to let the audience learn congratulations !
@conseq68404 жыл бұрын
1 1/2 months until my step 1 exam and before that series I havent had ANY idea of this stuff. I managed to ignore it until now and pass my biochemistry exams without even learning knowing what a apolipoprotein is. Now I feel like I know everything! Thank you!
@thepacemaker81654 жыл бұрын
This is work of a genius!
@shantanuvinodnair36785 жыл бұрын
Excellent video, you are by far the best medical channel on KZbin.
@Umir4455664 жыл бұрын
Shantanu Nair world*
@tenawobebetwo39178 ай бұрын
Or another mnemonic for HDL and LDL is: HDL= H*ealthy cholesterol, LDL= L*ethal cholesterol. FA being my reference though
@drvancouversa35817 күн бұрын
Good one!!
@jamgurl112Ай бұрын
It's wild how understanding evolves and just re-frames everything we'd previously learned. Because now all I can think watching this is: So ApoE4 which binds less efficiently to lipoproteins (effectively transporting low quantities of TG and Cholesterol) allows for more LDL to bypass the Liver and accumulate in peripheral cells increasing risk of strokes and heart attacks and carries less TG and Cholesterol to the brain for construction of myelin sheath construction and energy (cue dementia protective Ketone diet), and transports less amyloid beta to out of the brain. I know your goal was lipid Transport, but this is also helped me to consolidate ApoE4's part in dementia!
@prayformoe Жыл бұрын
HDL is such a favourite student you can just tell, the teacher finds it extremely helpful
@nalennaicker3 жыл бұрын
This was amazing! I finally get this pathway after trying to understand for so long! I really wish more meds student would choose to watch your videos cause their really fantastic, thank you.
@hamzashahid55435 жыл бұрын
Apo E , "E" for end , they have reached the end of their job and are ready for reuptake
@alih69534 жыл бұрын
Thanks
@jordanthomas9705 Жыл бұрын
Just in case anyone sees this, at 15:48 he says "LDL" (but meant HDL) when recapping the different directions for LDL and HDL. Easy to see what he meant but just didn't want anyone getting confused!
@AriRose993 ай бұрын
Dude I know these vids are older but I'm taking COMLEX/STEP 1 in 2 weeks and they're literally saving my life. TYSM Dirty!!!
@hafsajabeen53034 жыл бұрын
I LOVED LOVED LOVED THE SERIES. THANK YOU VERY MUCH
@ajaffs173 жыл бұрын
These videos are INSANELY amazing!!! Thank you!!!!
@janakotherova59044 жыл бұрын
Seriously, those three videos are awesome. Thanks!
@syedfehrsyedmuzafar591713 күн бұрын
Thank you man, you’re just a god send. I pray for u have a good day and a good life. Cheers
@rradventures17664 жыл бұрын
Simply AMAZING!! I take step next month and have been watching your videos every day! You've taken all the toughest concepts (and all the minutiae) to understand and saved me.
@suminarai79104 жыл бұрын
RR Adventures all the best!
@rradventures17664 жыл бұрын
@@suminarai7910 Thank you!! All the best to you as well!
@Lechu19823 жыл бұрын
@@rradventures1766 how did it go? i'm taking mine in feb
@msendejas47472 жыл бұрын
after struggling with this topic for all of 1st year and till now I finally have a strong understanding in less than 30 min on lipid transport!! Amazing is an understatement of this because im no longer scared this biochemical pathway
@Akordio944 жыл бұрын
You deserve the noble price!
@pragyasingh2297 Жыл бұрын
DM: I decided not to make it one video because I didn't want you to run home crying. **Me: watches all three back to back and bows bc THANK YOU for helping me understand more in 40 something minutes than reading/regurgitating the material from biochem books countless times without understanding it**
@yvonneachterman93052 жыл бұрын
Thank you, Jesus, for this awesome teacher!! With profound appreciation!
@michellevanbiljon41524 жыл бұрын
Amazing! Thank you so much or the 3 videos on Lipid transport - wouldn't have been able to understand it without your videos.
@usmanakbar15874 жыл бұрын
Agree
@姜周禮 Жыл бұрын
I finally got a clear picture in my mind about what's going on in these complex pathway. thanks a lot
@mysjackson885 жыл бұрын
How I learned it. HDL is high grade : so doing good job of removing cholesterol from the arteries. LDL is low grade, splattering cholesterol into your arteries and clogging them.
@TuttiFruity02147 ай бұрын
That’s not it’s function though. It’s attempting to heal inflammation. No inflammation then no clogging. We wouldn’t be very efficient as a species of our body function actively worked against us
@mailyncasado84726 ай бұрын
Thank you for teaching lipid transport with so much clarity !!! 🙏🏽
@moseebalihashim34333 жыл бұрын
After these 3 videos , I feel to loose all burden of biochemistry from my back
@faith4641-q8b4 ай бұрын
well said 🤣🤣🤣
@vishalmuralidharan45154 жыл бұрын
Thank you SO MUCH! It’s so refreshing to learn something by understanding than by just rote learning.
@jessicab10842 жыл бұрын
i was so confused until i watched these three videos. THANK YOU so much. I subscribed!
@mashaal38223 жыл бұрын
been putting these off for so long and now i have mastered these concepts in my dedicated period; thanks dirty you are the best
@supernova51073 жыл бұрын
Any of you people who have an upcoming exam need to send this guy a check.
@debigdogk9563 Жыл бұрын
GOAT- Greatest Of All Teachers. Thank you,thank you and thank you.❤❤❤❤❤
@monnoo8221 Жыл бұрын
generally, very niely explained... EXCEPT regarding the bad "bad" word. Normal LDL is essential and part of life, and necessary for the maintenance of energy metabolism AND membrane integration of EACH AND EVERY cell. And I hink it is not perfectly precise that LDL particles are swalloed. Many only discharge part of their content (?). What does it make bad is oxidation of its APO proteins, which prevent re-uptake by the liver.Those LDL are completely discharged and small. They accumulate in the blood, when there is high oxidative load, because the fail to be removed, especially if HDL is low. Since they are small AND the endothelium is in bad shape, they sneak in tinot the endothelium and beneath it. There they can be detoxified only by macrophages, which get foamy, and inflammatory. HDL also get oxidized under high oxidative load (glucose, low glutathione, etc) bu oxHLD binds to oxLDL and the double bubble can get removed by macrophages. So, it is a statistical game: high HDL reduces the number of dangerous bullets. HDL is transporting cholesterol back to the liver, but that it standard homeostasis. It is the FALSE reason to call it good. The cholesterol found in plaques is there for 2 reasons. pathologically, as part of the small oxLDL, and as part of the healing process, which needs cholesterol for new cell membranes. perhaps you could say also a word about Lp(a) here
@iMaMyst3ry3 жыл бұрын
You’re amazing! I’m totally sponsoring your pattern when I get a residency.
@alih69534 жыл бұрын
Awesome video and Thank you very much. Please post more!
@sirciphers51873 ай бұрын
I spit out my coffee when you said "I'm LDL and I'm here to be inside of you" LOL
@vitaminbrit19 ай бұрын
Truly the best explanation of Lipid Transport! Thank you so much
@erin2704 Жыл бұрын
I watched many videos that used different techniques and yours catered the best to what I just needed. Thank you.
@lisagonzalez29024 жыл бұрын
Omg, this was a fantastic way to break it down. And the mnemonics for lipid transports are way too good. I've written all of them down on my First Aid.
@ruksanakhan49893 жыл бұрын
This video saved me from reading numerous pages....🙏🙏🙏🙏
@geegeegee27723 жыл бұрын
hey im a Microbiologist this video so crisp and clear thank you for your effort
@harineepriya2 жыл бұрын
Thank you so much. I have finished watching all three videos and they were extremely helpful.
@disenchanted50654 жыл бұрын
Your dirty mnemonics are the only dirt i love in my life Thanks!!
@Sees002 жыл бұрын
"Apo E = enter liver" always gets the job done for me
@christinac11952 жыл бұрын
the world is a better place because of you
@faash89649 ай бұрын
Thankyouuu!!!!!!!!!! Do u know how much you’re helping people ???
@saco63473 жыл бұрын
Man, I love you. Still useful for step2
@ahmadharb135 жыл бұрын
7:14 gonna be my lick up line from now
@dr.davidadeolu21667 ай бұрын
@dirtymedicine Thank you for sharing your love and wisdom of life through this humble medium... A mini book will be well to come off these videos.
@geetikarao46303 жыл бұрын
thankyou so much !! this made so much sense. YOU ARE AN ABSOLUTE SAVIOUR!!
@vishnujanga80562 жыл бұрын
Medicine : Endocytosis of LDL DIRTY Medicine : hey i'm LDL , i'm here to be INSIDE of you
@jorgeordazjr.6639 Жыл бұрын
Don't know if this will help anyone, but an easy way that helped me memorize the function of ApoA1, was by saying ApoA1 "Ages" HDL. Idk why but it's short and really stuck for me, so putting it on here. Hope it helps
@dactaramma11 ай бұрын
I watched Ninja Nerd first but was so overwhelmed. Your video has made my resting heart rate go from 150 to 90 bpm. Thanks a lot. Kisses !!!!!!!!
@olalekanmohammed512 Жыл бұрын
Thank you buddy, you just saved a life
@zufanweldie3021Ай бұрын
I died when you said ''hey my name is LDL and am here to be inside of you" dirty medicine ended.hehe loveeee your videos dirty keep up the amazing job.
@vyoma19982 жыл бұрын
this was such a helpful series! thank you so much!!!! never understood or could remember this stuff in med school, but hoping it sticks for the STEP.
@fjaramillo887 Жыл бұрын
Thank you so much doctor, your videos are so helpful you truly have a gift to teach.
@nothilegumede5335 Жыл бұрын
you are amazing , Father of biochemistry
@bakareolamide43713 жыл бұрын
Thank you so much. I really benefited from this series. God bless you
@mariamgabadadze20333 жыл бұрын
I'll never understand who the hell dislikes these videos
@miguelalejandroherrera34143 жыл бұрын
Your videos make online classes so much easier. Thank you so much
@niharikasaraf35062 жыл бұрын
You are a God-sent person, my good Sir 🥺🙌
@myprettygirl913 жыл бұрын
you are a legitimate angel. Bless you!!
@dinayounis64732 жыл бұрын
thank you❤❤you made it really easy.. these mnemonics and stuff made everything clear
@ananaseh3548 Жыл бұрын
7:12 real smooth my dude
@RandomBlogs282 жыл бұрын
this helped me so much oh my god I feel so much better for my exam on Wednesday thank you!!!1
@wagnerlopes53603 жыл бұрын
Time for changing way of thinking. LDL is not bad. The body is not stupid to create something to harm itself...
@DirtyMedicine3 жыл бұрын
Then explain cancer
@anthonymarcel2465 ай бұрын
You are doing Gods work. Thank you
@user-gi6ig8xt1v3 жыл бұрын
Awesome explanation and mnemonic. God Bless You!!
@Vahe3455 ай бұрын
Why is it harmful if LDL goes into the peripheral cells if there is a receptor for it. What function does it have in thr peripheral cells?
@mm86504 жыл бұрын
You have saved us all
@hurricanebaby15 ай бұрын
amazing set of videos!
@onshindeyah2 ай бұрын
“There is a lot of d’s” you said Deez what sir? Greetings from turkey lol 1st grade medstudent here working for finals. as you mentioned your videos are a little bit undetailed but they do a huge job on understanding the big picture thanx a lot
@hamzahhameed7782 жыл бұрын
Probably low-yield, however FA states the IDL still has Apo CII on its surface.
@sonias11733 жыл бұрын
Simply You are awesome. Thank you so much for made it easy.
@pallsr92392 жыл бұрын
Okay I feel confident now Something is better than nothing thanks a lot
@jmanciaz Жыл бұрын
You're ridiculously good. Wow. Thank u!!!!
@jacobgarcia904 жыл бұрын
This saved my ass. HIGH YIELD 👌🏻
@nurmujahed2 ай бұрын
Just pass biochem thanks you bro❤️
@soeminwaiyan27343 жыл бұрын
Mom: Are you watching those digital touchscreens again. You can't gain nothing but eye issues. me: Nope mom. I'm watching dirty youtube lectures. Mom: what? dirty lectures? my god Me: don't get me wrong mom. I'm attending biochemistry class that goes by the name "Dirty Medicine"
@malinyamato22914 жыл бұрын
I am a newbie and very thankful for your easy to understand walk through. But, pls excuse my ignorance: Why is it bad to transport cholesterol to the cell? Isnt cholesterol needed for maintaining the cell membrane? What happens without LDL?
@wagnerlopes53603 жыл бұрын
Exactly! Bad way of thinking and misconcepts. The body is not so stupid to create something to harm itself...
@kirsten97293 жыл бұрын
It’s only bad when you have very high levels. When you have too much, the LDL will deposit lots of fat and cholesterol in the wrong places such as your artery walls. This leads to atherosclerosis and coronary artery disease.
@courtneychaney57492 жыл бұрын
This is awesome...currently looking at this in two separate classes and felt like I was missing something for full understanding, until now!
@artimalik11243 жыл бұрын
You r the best drty medcne 🇮🇳
@sampathr24 жыл бұрын
Tks very much for wonderful lecture on bio Chemistry of lipoproteins.
@raghadar1403Ай бұрын
awesome and brilliant... thaank youuuu
@anhthopham27683 жыл бұрын
wonderful series, thank u very much.
@hamedbaharloo91032 жыл бұрын
Extraordinary and superb explanation
@jaz782510 ай бұрын
i loved the three part series.....but you literally stopped at the chylomicronin remnant the liver, what happens next.......how does this connect with beta oxidation. Excellent breakdown of the apoprotien
@roree.m73973 жыл бұрын
You are THE BEST
@ramaal-dabbas21364 жыл бұрын
Thanku so much really ❤️❤️❤️❤️
@arturmukhamed-aliev91414 жыл бұрын
Hi! When are you gonna take 1st step?
@AbubakarUmarMusa2 жыл бұрын
Great 👍
@veenaveena797 Жыл бұрын
You brought so much clarity, great work
@hillaryfrench1743 жыл бұрын
Thank you for saving me!! Great videos as always!
@sharanjhaveri63244 жыл бұрын
Thanks man, You made my life oh so much easier today