Low-dose Lithium Shows Significant Benefit In Alzheimer's Human Trial | Dr Thomas Guttuso Ep 2

In this video Dr Guttuso talks about two positive random controlled clinical trials of low dose lithium with Alzheimer's and two on going trials.
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Thomas Guttuso, Jr., MD, is a professor of neurology at the University at Buffalo. He has been treating patients with Parkinson’s for over twenty years and has published over thirty articles in leading medical journals. Dr Guttuso recently published the book “The Promise Of Lithium” on the use of lithium supplementation to potentially slow the progression of both Alzheimer’s and Parkinson’s. He is also currently conducting a placebo-controlled trial in examining the effects of low-dose lithium therapy on long COVID symptoms.
Papers mentioned in this video
Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
pubmed.ncbi.nlm.nih.gov/21525...
Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease
pubmed.ncbi.nlm.nih.gov/22746...
00:00 : Two randomized clinical trials results from Brazil
07:06 : Two on-going trials
16:25 : What would the next steps be for a successful outcome
📖 The Promise of Lithium book amzn.to/3HSCP5R
🌐 Website for the book: www.promiseoflithium.com/
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#alzheimer #lithium #parkinson

[@ModernHealthspan]

The Promise of Lithium book amzn.to/3HSCP5R Renue By Science 10% discount: tinyurl.com/3bj65wev For Subscriptions, use code SUBMHS DoNotAge 10% discount code MODERNHEALTHSPAN donotage.org/products/ NOVOS Core & NOVOS Boost $5 with code MODERNnow5 novoslabs.com/?ref=3957 ProHealth 10% discount code MODERN : prohealth.pxf.io/c/3176409/1541296/17976 InsideTracker 20% discount: insidetracker.sjv.io/DVmqkn with code HEALTHSPAN20 Bulletproof 15% discount code HEALTHSPAN15 tinyurl.com/24hrxt72 If you would like to support our channel, we’d love a coffee ☕…thank you! www.buymeacoffee.com/mhealthspan Dr Guttuso Playlist: tinyurl.com/36ra6x2h

[@larryd6143]

I had read of two studies in Texas and Japan. They compared areas where Lithium was in the drinking water at just under 1 to 2 mg. per liter. and areas where there was none. Areas with Lithium had lower rates of murder, suicide, physical abuse and substance abuse. I live in an area with no Lithium in the water. I have been supplementing with 5 mg. Lithium Orotate which is about 2.2 mg. elemental Lithium. It has helped my ME/CFS brain fog and I rarely have migraines anymore. It seems clear that for optimal neurological health the body needs to take in a small amount of Lithium every day. I don't understand how we can have a MDR for so many elements but nothing for Lithium. When I told a new doctor I was supplementing she had me tested. I must have missed a dose as the level of Lithium was undetectable. This means none in the water or in the foods I eat.

[@StaffanOlsson-sw6tx]

5 mg Lithium orotate does wonder pn 86 year old woman. better mood and Better memory.

[@thetackroomtx]

What brand are you using?

[@ModernHealthspan]

Thanks for sharing.

[@shirleyharold3887]

Low lose as 0.3 mg seems already have benefits, amazing.

[@thetackroomtx]

If you don't mind, what brand are you taking

[@DanaVastman]

@@thetackroomtx 1000mcg from Life Extension

[@ModernHealthspan]

Hi Shirley Thanks for sharing.

[@ancesthntr]

FYI, Life Extension sells a 1 mg pill.

[@ModernHealthspan]

Hi Thanks for sharing.

[@KenOtwell]

The Novos Core longevity mix from Novos Labs includes 1 mg of lithium. Sounds like a good level based on this interview. Thanks!

[@ModernHealthspan]

Hi Ken thanks for sharing. I had not heard of lithium as a supplement until Dr Verbergh of NOVOS spoke about it in our interview.

[@incognitotorpedo42]

@@ModernHealthspan It's widely available. I've been using Swanson's lithium orotate product for years. It's 5mg elemental lithium. It's about ten cents a day.

[@ronm6585]

Thank you.

[@Battery-kf4vu]

I read that 5mg of lithium orotate is almost as effective as 100mg of lithium carbonate. So maybe it is the orotate that makes it so effective at low dose?

[@aclearlight]

Are there any hypotheses at this point regarding mechanism of action?

[@paulwolf3302]

I've been taking lithium orotate, 10 mg/day for a few weeks now after watching these videos. Like most supplements, I have no idea if it's having any effect. I tried fucoidan but it dropped off my list after I decided it was some kind of Japanese folkore. Omega 3 fish oil is barely, but still on my list. We'll see if lithium stays on. I'll go through this bottle of 180 pills, and after three months decide whether to reorder it. My problem is that I take a lof of different supplements and have no idea which ones work and which ones don't. Overall I'm in really great shape, which I attribute to doing a lot of exercise and losing weight.

[@incognitotorpedo42]

Paul, what would not getting Alzheimers feel like? I suspect it feels like "nothing's happening".

[@karenfarrell6158]

Kal sells a lithium product. Kal is a very high quality that has been around for decades. It’s very inexpensive as well

[@johnely5050]

I have just started taking 5mg of lithium orotate for major depression.

[@bobthrasher8226]

Does anyone know if lithium orotate dissolves in water? What would happen if one were to empty a 1 mg capsule into a gallon of water? Would it dissolve or just drop to the bottom?

[@harmonicresonanceproject]

It's in tobacco, I had no idea!

[@user-rx9wt1fv5s]

Can I start lithium 5g daily first time and try weening off Mirtazapine at the same time?

[@rui-9-cs315]

cool

[@MrSaxxie2]

So what were the lithium dosages tested in the studies???

[@ddutton4716]

He mentioned them at 4:00 and on a bit.

[@ModernHealthspan]

Hi Sax thanks for your question. Dr Guttuso does cover this in the video although one of the things he says is that dose is still being worked out. Reading the book they mostly seem to go for a specific plasma concentration of lithium. However the specific numbers for the two Brazilian studies were 150 mg and 0.3mg and his own trial is 10, 45 and 150 mg.

[@aclearlight]

@@ModernHealthspan Thank you!

[@bobthrasher8226]

It is possible the LATTICE trial is "designed to fail." Given the huge market that AD and PD are, the NIH/FDA works hand in hand with industry to make sure only pharma drugs get good clinical trials and in the end the drugs are often of modest or no benefit for AD. The latest AD drugs targeting beta-amyloid are extremely expensive.

[@jancerny2831]

Point 3 miligrams of what? :-) :-) You are not normal.

[@kevindouglas2060]

I don't see how this can possibly work. How are you going to patent it? How are you going to make it expensive enough. Stuff is produced based on profit not efficacy.

[@OttoHunt]

A dose suggestion of human supplementation was never stated. 🙄

[@DanaVastman]

It was explicitly pointed out that there's not much interested in a free drug from the pharmaceutical industry and therefore study money is limited. The results seem pretty cool. Why the weird emoji?

[@DanaVastman]

Personally, I take the 1000 microgram caps from life extension. Seems that's a pretty good starting point. So small yet potentially significant. Why do you want people to make up something or just specify something that hasn't been researched sufficiently yet? Can't hurt you

[@ModernHealthspan]

Hi Otto, thanks for you comment. Dr Guttuso says we still don't know the optimum dose. That is one of the aims of his trial which is using 10, 45 and 150mg. From the book it looks like 45 was most effective - though as a note this is quite high as most supplements are 1 or 5mg. He said he will be publishing the results soon which should provide some more guidance.

[@albardo08]

@@ModernHealthspan A dose of 150 milligrams of lithium daily will interfere with thyroid metabolism.

[@OttoHunt]

@@ModernHealthspan Kal makes a sublingual 5 mg lithium tablet, with that suggestion to take it close to bedtime. Dosing advice from supplement manufacturers is, of course, suspect, but I have been using this product for years with no obvious ill effects. BTW, lithium is naturally present in the water in some places, where it has been noted that there is less suicide.