ENZYME ACTION: Lock and key compared to Induced Fit Model in lowering activation energy.

[@ayeshasidat5830]

Miss Estruch is the freesciencelessons for A-level - a godsend!

[@MissEstruchBiology]

☺☺ aww wow thanks! High praise indeed!

[@firekiller8924]

fr fr maybe you guys should do a colab

[@Quandale_jingle]

Such a great video. At first I didn't understand why the active site moulding around the substrate lowers the activation energy. Then when you said it makes it easier to brake into the products, which requires less energy, made it make so much sense. Thank you for this video.😄

[@MissEstruchBiology]

So happy it helped you!!! ☺️☺️

[@edwardjohnson4886]

Very helpful for my NEET. Lots of thanks from India

[@MissEstruchBiology]

Glad it has helped you 😊

[@iluvdawgs00]

I jus recently found out it channel n ur such an amazing kind teacher ilyy we stannn u afetr watching this video I don't think a lvls is that hard that I thought it would be thank u for a lvls sound easy I appreciate it🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤

[@Kiwiii_Love]

Have my year 9 biochem exam tomorrow and we need to know about the induced fit model. Your video helped me understand it a lot better . Thanks!

[@artemismori4354]

i dont think youll need to know this model that in depth atm in year 9

[@razuahammad3351]

Thanks you so much mam from Bangladesh.

[@MissEstruchBiology]

You're so welcome. Wow, I love that you are watching all the way in Bangladesh!! Thank you

[@razuahammad3351]

@@MissEstruchBiology You explained in a very nice way. I shared your video with my friends. Again thanks, Mam.

[@TehRedBoy]

love that from you miss es

[@MissEstruchBiology]

You're so welcome 😁

[@jameswisz1112]

One of the best videos on KZbin

[@MissEstruchBiology]

That is too generous! I really hope it helps you.

[@tesfaalemayehu3869]

nice explanation

[@GopalSharma-cp9vs]

Thank you so much mam !😭❤

[@MissEstruchBiology]

you're welcome

[@sumsherali5854]

Thanks a lot

[@anjalibhandari3851]

once again, amazing video :)

[@MissEstruchBiology]

☺☺ thank you, so glad you found it helpful

[@smile2168]

You are amazing!! ❤️🌼

[@justsomeone2001]

Thank you so much! ❤

[@MissEstruchBiology]

you're welcome

[@sanket_kadam_]

Great explanation 👍

[@MissEstruchBiology]

Thank you 😊 Hope the video helps you

[@artemismori4354]

Miss, which exam board do you teach? Are all you vids suitable for snab?

[@ahcenemallem7901]

Thank you very much for this video , but I want more details about how to change the structure of the enzyme in the active site in the Kochland model induced fit . I mean how to change the sites of the acids amino to obtain a three-dimensional structure for structural integration with the substrate material. I searched, but I did not find sources on the internet.

[@Nati-je8db]

Good

[@MissEstruchBiology]

Thanks :)

[@VeronKasoma-rd6rn]

You are amazing

[@MissEstruchBiology]

Ah thank you

[@renokreuz3414]

both lock and key and induced fit models are accepted models, and there are papers to show that both models are represented by different enzymes.

[@MissEstruchBiology]

Hello, Thanks for highlighting this. My videos link to the AQA exam board and so follow what students need to know for this.

[@fatims27]

miss, could you explain how come in the induced fit model the substrate bonds get weakened which causes the activation energy to be lowered? im finding it a bit hard to grasp the correlation between the two (the bonds being weakened which causes the activation energy to decrease)

[@MissEstruchBiology]

the active site moulding around the substrate puts tension of the bonds in the substrate

[@prof.oluolatunji8819]

i hope i can use this in my psychopharmacology class ?

[@MissEstruchBiology]

hello, If you have a specification for the course then you can check to see what level of detail you need to know this topic in.😊

[@prof.oluolatunji8819]

@@MissEstruchBiology Thanks

[@haabeel7702]

cheers

[@Nati-je8db]

I love ur voice

[@MissEstruchBiology]

Thank you!

[@iluvdawgs00]

SLAYYYYYYYYYYY

[@jennipherchanda6266]

Aren't enzymes specific that's why the induced fit model isn't accepting 🤔🙄

[@jennipherchanda6266]

Accepted*

[@jamiefrancis3758]

@@jennipherchanda6266 They are specific. The induced-fit model doesn't change that. The enzyme is able to bind the substrate but the slight change in the shape of the active site is what causes the reaction, otherwise, you would just have two molecules binding together. The active site is technically complementary to the 'transition state' which is where the substrate is at its highest potential energy to react.

[@alemtsehayseifu8147]

l says for you Thanks

[@MissEstruchBiology]

You're welcome 😊

[@ruthmamush8437]

I thought the substrate was the one who change it's shape slightly 🤔

[@MissEstruchBiology]

Hello 👋 its the enzyme that slightly changes to fit around the substrate to put a strain on the bonds so less energy is needed to break the bonds on the substrate.

[@user-vq4qy2hq5i]

Do we still need the lock and key model for AQA?

[@MissEstruchBiology]

No, induced fit is what is accepted

[@Rakesh-sh2we]

i dont want to be alive anymore

[@MissEstruchBiology]

www.samaritans.org/how-we-can-help/contact-samaritan/ it is really important that you use this contact for help.

[@chuchu6891]

😂 sorry, I hope it's a joke