Alternative Approaches to Molecular Biology | MIT 7.01SC Fundamentals of Biology

[@smilingcoolsanthu]

it's helpful that who can't pay money to join in corporate/private institutions for learning things, thank you MIT for sharing

[@chrislloyd3096]

KONDURU SANTHOSH KUMAR GUPTHA exactly. If you truly want to learn money will not be the final say

[@albertescamilla]

for sure, but without credentials you in all likelihood won't be able to utilize any of your new found knowledge.

[@JorgeRamos-xw6dy]

Imagine having him as a teacher? I'd be looking forward to my next lecture.... and it is because of professors like him why MIT turns out top scientists.

[@Movewithkhu]

so true

[@Movewithkhu]

here in india most teachers r just bullies who shame u if u ask them a valid doubt

[@carlinlapo]

This is quite average no ?

[@drfadiabbas4439]

it is crystal clear when you have biology teachers like this , you would surely hit the target of your self actualisation . clearly said

[@lasaventurasdevitoelgatoma3405]

To MIT: please consider uploading the entire course. It is cristal clear n engaging!

[@jf5106]

He is a fantastic instructor.

[@stimpyfeelinit]

He's fantastic! I had trouble finding a lecturer that wasn't a f*male.

[@ricardoarguelles6706]

@@stimpyfeelinit ? gender has nothing to do with being a good instructor mate.

[@monicac5980]

@@stimpyfeelinit eww, an incel. Go back to your cave

[@Sulbee]

I have not found a better teacher than him in my entire life!

[@josephmusonda7548]

MY GOODNESS!!!! This is fantastic.He makes it so interesting .He just you a clear picture.Brilliant!!!!

[@ujjainimukherjee4328]

I'm currently doing masters but I'm listening to him because it's very refreshing. And I miss lectures when we could actually see the professor. Online classes aren't the same

[@danielcorcoran5562]

This guy is incredible I could watch for hours, hope that when I go to college my lecturers will be somewhat like him

[@gautamgopal3517]

Hey... same feelings bro....

[@hardhikreddy9179]

G's up Sal

[@zuhairaasri1362]

2020 and watching this, old school never get old, thankyou prof

[@DaniFilth87]

Though being an outspoken PowerPoint advovate: there's nothing better than good, old-fashioned blackboards

[@gregorykarimian2216]

i remember "ex"ons as genes that will be "ex"pressed

[@feedmewifi_477]

well, the portions of genes

[@notme-ji5uo]

i remember introns as mrna thats stays inthe nucleus and exons as mrna that goes out

[@royhughson9885]

“Ex”ons “ex”it the nucleus

[@hardikb15]

@@royhughson9885 yep.. was about to comment that

[@lisarey1969]

Hi MIT! I really really love all your biology videos please do upload more of this kind of videos!!! It would be really helpful thanks!!

[@ayunajombik8169]

ALL RIGHT!!! 😂 Professor Lander is an absolutely gifted educator 😍 Hope I’ll see him one day 🙏🏻

[@mkeamy]

Lander is a highly distinguished academic. This is an MIT thing; Intro course lectures are always taught by the best; when I was there half a century ago, I learned molecular biology from Salvador Luria in that very same room. The departments seek to inspire as a way to recruit undergrads to their discipline. Glad it hasnt changed.

[@colinebied-charreton1343]

Prof. Lander is simply FANTASTIC

[@smokinghorsey9]

To what he's saying @22:50, I remember the difference by saying exons are executed. The pieces of code that remain are the ones that are translated into proteins, etc. That is, they form the code which is executed. The introns are not executed. They are removed. EXons are Executed.

[@marlenesoifer7219]

You have no clue how much your lectures are doing for me. We shall see

[@quantumcrash7266]

So down-to-earth and cool, Dr. Lander is.

[@TheJTK123]

This is amazing. I love the way he teaches.

[@rzgre7611]

I am so glad to be able to see and understand this video

[@zfesiha]

I don't really know why but I am glad to see someone in Turkey is watching these lessons like me. Kolay gelsin :)

[@drewabrams2903]

Agreed with the under comment , I don't have money , this was an incredible lecture , I couldn't help but notice a relation to duality , and also the same way the frequency or RNA structure of viruses work on the same scale as of fear in brain wave patterns , fascinating stuff

[@SaracenSal]

He deserves a round of applause!!

[@jnielsen20]

DNA and RNA are different biochemically, they use slightly different sugars, called riboses. Infact the only difference between these two sugars is that RNA have an extra OH group on the 2' carbon. However the difference this makes is profound, since the OH group is close to the phosphate group at the 3' carbon in RNA it can interact with it very easily and cause the RNA to come apart. Thus RNA is less stable than DNA. RNA= Ribonucleic acid DNA= Deoxyribonucleic acid

[@rovidius2006]

How big of a brain would you need to design something like this ?

[@sheriffmelon7113]

Thank you guys for posting all of this!

[@JoshuaOngalo-s5t]

Oh my god!! this is a great video, I enjoyed it to the end. Please Prof upload more.

[@mitocw]

KZbin playlist: kzbin.info/aero/PLF83B8D8C87426E44 Course materials: ocw.mit.edu/7-01SCF11 Best wishes on your studies!

[@artjomplaunov136]

turn on the captions and read them at around the start of 0:19

[@mariyanezhyvaya5170]

thank you so much! loved this lections)) This professor is awesome! This is much better than I had in school) Thanks again!

[@kanundash]

2016 Now we have crispr cas9 a DNA cutting tools

[@doge-coin]

This is a really interesting and helpful course. Thanks a lot MIT!

[@ciprianomauricio6938]

Great explanations! And drawings. And excitement. And handwriting. Makes the subject very clear. Thank you!

[@nandakumarcheiro]

Dear Syddharth Hatila the Tolemerase is really non-linear as if stress applied compression as observed by health line reduce the length of compressed spring .Kindly ask Nobel prize winner Elizabeth.

[@rohithparashivamurthy3268]

Man those blackboards look addictive and appealing

[@rustyG774]

This professor, is really amazing. Thank you for this.

[@Liquoricilicious]

Where is the first video? He started in the middle of something...

[@mitocw]

+Liquoricilicious These videos were deliberately edited to be snippets of concepts for the 7.01SC Scholar course on MIT OpenCourseWare. See the course to see the snippets in context at ocw.mit.edu/7-01SCF11.

[@hemungkapoor2000]

Thank you so much MIT for these wonderful lectures. It's really very helpful

[@maksudkerluku7517]

wonderful videos, amazing professor and scientists. Thanks for sharing

[@swadeshtaneja3512]

Great service to humanity at large.🙏🌹😊

[@reyanaganguly7650]

The lectures are excellent. However they are not quite ordered. Can anybody tell me where to get the ordered playlist? Thanks in advance

[@mitocw]

KZbin playlist: kzbin.info/aero/PLF83B8D8C87426E44 Course materials: ocw.mit.edu/7-01SCF11 Best wishes on your studies!

[@vatsalpatel7733]

Board and chalk type of education is best Thanks MIT

[@kevinhall3188]

Agree as Whiite boards are shown fully scripted and we snap shot the whole lot in a few econds but retain less than if a teacher writes ther words and drawings. As they write we watch and see every letter planting the unfolding data into our minds.

[@farahali5754]

I keep by my heart this lecture

[@StarcraftDr]

Very nice, was able to learn some riveting virus rep,ication mechanics!

[@jessicawhite6369]

Your videos are very helpful and so much fun! Thank you for sharing!

[@albertalawyer]

I get it but I don't all the same. Just pick up "Molecular Biology" and understand the WHOLE thing and you'll know more than most Mol Bio grads.

[@Stoic_harsh]

❤️ from INDIA

[@butcreate]

Amazing lecture. Thank you so much. But I am confused that splicing occurs naturally in organism or human do them to make new generations or new gene?

[@vikramthimaradka97]

Satisfying explanations for a curious learner!

[@michaelg631]

Talk to phil because he's really cool.

[@sreeanilkumar3333]

Thank you sir. Loved your lecture.

[@christianwellness4363]

what a great teacher !! makes me wanna go back to school,lol.. thank you for the lesson :)

[@phill6159]

Could someone post a complete link to his lectures in order.

[@mitocw]

View the complete course: ocw.mit.edu/7-01SCF11. Best wishes on your studies!

[@jeremiasrobinson]

His handwriting is very nice. When most people write on blackboards their handwriting doesn't look so good.

[@mkeamy]

looks like 10-250! Those are good memories

[@rooooooby]

Great Video. PS you have beautiful handwriting.

[@camillakristinekarlsen5358]

Thank you! You're an awesome teacher.

[@srimuharyati2387]

Asik juga belajar kayak ginian...

[@srimuharyati2387]

Cool stuff, cool stuff ...

[@hardikrajpal2410]

I'd like to thank IIT Bombay's teachers for making me search KZbin for MIT lectures

[@nitinchalla782]

🤣👌

[@蕭博允-q7z]

16:20 CRISPR can do it?

[@carlinlapo]

Only one finding this average to low level compared to Europe? They must do a really good job in applying the knowledge afterwards to be such a well-known institution.

[@hstudy8406]

A strange and good way of teaching

[@chaitanyadeshmane8243]

Anyone know a lecture series on Genetics and Cell Biology which is similar to this professor's teaching style and depth of content ? Please let me know.

[@HarshRaj-s3d]

10:00 continue

[@chivaking]

I learned a lot today.

[@AlonsoRules]

15:35 - HIV lesson

[@bernardoabreu4910]

Thank you

[@zengdu6187]

Thanks You so much!

[@dantescanline]

Everyones already saying it, but yeah he's amazing.

[@farahali5754]

This lecture I knew from it Yeah that DNA is the key to treat cancer .

[@danwilliams7354]

What are the prerequisites for such a course? Does anyone have links to appropriate online courses. Assume someone with zero biology and high school chemistry but nothing else - where would i start? Serious question - I realise it’s a long journey!!

[@mitocw]

According to the Syllabus (which you can find in the complete OCW course site: ocw.mit.edu/7-01SCF11), there are no formal prerequisites but you will need to be familiar with the concepts of atoms, chemical compounds, and chemical bonds.

[@danwilliams7354]

MIT OpenCourseWare thanks for the reply. That’s good to know, although listening to him I still feel a little lost. He talks about proteins - to understand what a protein is I think I need a grounding in biochemistry, and looking at some biochemistry courses it feels like you’re lost without a grounding in organic chemistry. So I’m going to start there and come back here when I’m ready!

[@siddharthhattila]

When DNA replicate it is in 'S' phase i.e. not condensed in form of chromosome, than how can it be linear and have telomere??

[@eaudesolero5631]

how does splicing work to throw out sequences? why not use this for viruses that have stuck their dna into ours?

[@ShakespeareCafe]

Best watched at 2.0x speed You can learn all this from any molecular biology text book in much greater detail Modern university education is a lot of hand holding He could have just showed slides instead of wasting time on the chalkboard

[@asdfafafdasfasdfs]

Is this playlist in order? the ordering is awkward...

[@mitocw]

You are right! Thanks for your note. It looks like the original ordering was lost on KZbin. We'll see about fixing it. In the meanwhile, you should view the course on MIT OpenCourseWare at: ocw.mit.edu/7-01SCF11. Everything will be in their proper order and there are other materials too! Problem Sets with Solutions, Exams with Solutions, Lecture Notes, etc. Best wishes on your studies!

[@asdfafafdasfasdfs]

@@mitocwthanks for the quick reply!

[@travisbickle3835]

This is like finding a gold mine for free.

[@ahalyaaanandan5460]

why s dat only Poly A tail is added and not Poly G or T or C tail at the end.

[@jklawatsch111]

I want to tackle your question by pointing out, that you made already a mistake in your question and I am not talking about those general language mistakes. What I am talking about is the following thing: You want to ask something about a "Poly A tail" but it seems that you don't have in mind that those Poly A tails only occur in RNA, not in DNA. Your suggestion to use G, T or C implies that there have to be molecules like GTP, TTP or CTP. In the case of GTP and CTP you would be right but there's a problem with TTP. It turns out that it only exists dTTP or UTP. There is no TTP or dUTP. Those molecules simply does not exist in an living organism. Therefore there is no way a RNA Poly T taile could be formed. "O.k. so far so good", you might think, "but my question still stands: Why s dat only Poly A tail is added and not Poly G or U or C at the end." (to use your way of english) ??? Well, now we have a real question which can be considered. There are those molecules ATP, GTP, UTP and CTP. So why does the cell only use ATP to form a Poly A tail and not GTP, UTP or CTP? To answer this question we have to look at it from a completely different angle. Most of the time the energy household of a cell is managed via the usage of ATP as an energy resource/an energy storage. Since cells often have to handle meaningful amounts of energy they also have a kind of big amount of ATP itself. Since GTP, UTP and CTP are not used to store and/or provide energy the concentration of those molecules are quite low. Therefore it turns out that the concentration of ATP in a cell is much much higher than the concentration of GTP, UTP or CTP. This fact causes that it is much easier to form a Poly A tail instead of other variants. If it was a Poly C tail for instance the cell would have to produce more CTP just to fulfill this purpose of forming a Poly C tail. This extra production of GTP, UTP or CTP would need an extra amount of energy. So long story short: To form a Poly A tail is much more energy efficient than forming a tail out of other nucleotides. I hope this explanation is understandable and I hope that this is an appropriate answer to your question.

[@komalkosar1228]

@@jklawatsch111 great

[@monicablindheim7920]

Love it!

[@edithakinanahancherelyteam4145]

Tampa done Cacai

[@nandakumarcheiro]

Telomerase at the end of chromosome split at one end acting as a spring when lose its spring back perhaps perhaps compressed and not relieved leading to aging perhaps decline in immuno resistivity.We are interested in human Telomerase perhaps anybody studied based on palm print analysis where health line breaking the life life acting on T cells connected by error committed by Telomerase. Thank you Professor Sankaravelayudhan Nandakumar.

[@GoldSlidePark]

Eric Lander, are you Narduar the Human Serviette's father?

[@jesseleavitt2818]

Why is it that the virus has a single base pair UG codon among the normal three pair codons?

[@moorpmoorp]

Jesse Leavitt he drew it that way for a reason to make the second part more visible. It should be three and there is always three but the AUG from the next start codon would have been cut off. The point is AUGCTUCAUGGT |AUG|CTU|CAU|GGT would be read by the first one. BUT another start codon is there. See it caught between |CAU|GGT. There's an AUG there. That three letter section is called a reading frame. There is another start codon stuck between two. So you shift your reading frame.

[@farahali5754]

Yes

[@Mahbod2]

In 32:56 AUG-ACU-UG ?????? How it possible ? only two nucleotides ??? UG ??

[@farahali5754]

Telomerase an enzyme I listened this lecture

[@eaudesolero5631]

what would happen if we encode human dna into a circular configuration?

[@hardikb15]

it won't be able to divide into 23 pairs of chromosomes

[@imisa4778]

Thanks

[@chiranjib-konwar]

does proteins exist as cells at the surface of human skin?

[@Thatsryt]

Chiranjib Konwar Cell is made up of several molecules largely by protein & lipid. So, to much extent protein is a part of cell, accounting for 50-60 % of its cell membrene .

[@chiranjib-konwar]

thank you Sidharth...

[@ashisborah19921]

Proteins are molecules that make up cells along with lipids and carbs sometimes. We love to term protein as the building block of all cells because they shape and perform metabolic functions for you keeping you alive. Nice to meet an Assamese person having similar interests.

[@xinli9762]

Agree to KZbin's Terms of Service.

[@qone89]

Need to talk to the person at Harvard about the intron and exon nomenclature lol

[@abhyudaysingh3911]

U guys r 🥰

[@jonetyson]

He left out double-stranded RNA viruses, such as reovirus!

[@AleifrLeifrson]

He accidentally a base in the last part =P

[@tianbohuang2963]

im in 5th grade and i even understand this

[@multiversossaltamontes7374]

yeast million bases, fruit flies, 4 chromosomes...etc..

[@drnowcomewithme]

Adam anlatıyor moruk

[@doubledoggo5668]

What are the viruses called that are able to read mRNA in 3 different frames like he showed at the very end of the lecture? Any specific examples?

[@aminamouna5255]

VIH

[@kuruptgt]

uh-oh. MIT is in trouble.

[@elshroomness]

Introns go in the trash. Exons are excited to be use.

[@anonymoose3423]

elshroom ness Actually some introns do encode functional RNAs and participate in other gene expression regulation processes

[@ciprianomauricio6938]

Introns stay in the nucleus, Exons exits nucleus and gets turned into proteins in cytocol :)

[@mywa8314]

Isn’t this outdated?

[@creatrotera]

MB02 lol