Myeloproliferative Neoplasms (MPNs) - Myeloproliferative Disorders - CML, PV, ET, PMF

[@MedicosisPerfectionalis]

🦠Antibiotics Lectures: www.medicosisperfectionalis.com/ 📝 Download Notes: www.medicosisperfectionalis.com/

[@catherineportland503]

Antibiotic bring down my platelets with et jak2. Why. Can you do a video on this

[@phinie1487]

Bro, you've accomplished something my teacher couldn't do in an hour...THANK YOU!

[@MedicosisPerfectionalis]

My pleasure 😇 I am honored! Can you please help me by sharing?

[@roboodonnell3224]

Thank you for producing the quality of informative videos. Your strengths in knowledge and comfortable delivery of the subject matter is very appreciated. I am 65 anf recently diagnosed with JAK 2 positive - ET working on a partial intestinal blockage tomorrow with a colonoscopy evaluation. Your gifting of this knowledge has helped me get a grasp on the mechanisms that are in place. Thanks much gratitude, Rob'O

[@giftn9531]

This channel has become a lifesaver in this pandemic. I Should've come hare sooner, coz I can barely understand a thing that my lecturer says.

[@sohailasghar8471]

Another precise comprehensive lecture. You are making study easy day by day.

[@MedicosisPerfectionalis]

Yeah! We’re making history 😁

[@ruthaidoo7222]

You’re amazing 😉 My favorite part is “Pay attention,pay attention!” I was actually losing attention 😂❤️

[@MedicosisPerfectionalis]

Haha 😂

[@preeti9750]

CAN'T THANK YOU ENOUGH !!!! @medicosis you're a genie! My finals are near and your videos are helping me more than I could imagine.

[@MedicosisPerfectionalis]

Thank you 😊 Good luck 🍀

[@Tharuspidy]

Hi im a 4th year medical student from SRILANKA.. :) your videos are sooooooooooooooooo much helpful in my studies Keep up doing these! Greetings..

[@MedicosisPerfectionalis]

Thank you so much 😊

[@alanoudalessa400]

Lifesaver for hematology haters

[@MedicosisPerfectionalis]

You are absolutely correct 😂

[@debbie9962]

Alanoud Alessa agree!!

[@manalmuneeftamer8846]

Can't agree more

[@benjaminmacdonald7656]

I just wanted to say thank you for all the work you have put into your channel. I understand that the information provided is primarily intended for individuals in medical school. However I was diagnosed with myelifibrosis related to an issue with CLR2 genetic defect. You have provided me with a great deal of comfort by way of educating my simple a$$. Good luck to you.

[@tehabarth]

week of lectures on this at school, first aid, and like 3 other resources and this one video made it click. KEEP DOING WHAT YOU DO

[@MedicosisPerfectionalis]

I sure will! Thanks a ton! Please share:)

[@ButterflySims]

What a great intro to MPNs! Just a heads up though. These do indeed TEND to be disease of the elderly, nevertheless being ‘young’ does not mean you cannot get these problems. I got diagnosed with ET just after my 34th birthday and looking at my blood test data from the years prior (and ongoing side effects) it is likely that I was already walking around with it since my 30th.

[@jessiewabbit]

Myeloproliferative Neoplasms are interesting. I was originally diagnosed with ET, and after 2 years my hematologist now says it's PV, but wants to monitor close, as my wbc is now climbing as well! At the ripe old age of 23.

[@MedicosisPerfectionalis]

What! I am so sorry to hear that...Please, remember to never let the disease beat you...and tell me if I can help...Thanks for sharing!

[@yashaswiyerunkar3]

I had found this channel randomly and I watch all haemat videos from here😍 love this channel ♥️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@andreyscumpieru1371]

This really helps grasps the concepts of MPNs thank you!!!!

[@MedicosisPerfectionalis]

My pleasure 😇 Can you please help me by sharing?

[@andreyscumpieru1371]

Shared with everyone in my class!

[@ashozy1003]

lol you cracked me up with saying don't be pessimistic I was just thinking if I really have it. You are funny makes it less boring thanks :D

[@MedicosisPerfectionalis]

You’re welcome 😇

[@mitraahmadi7762]

Thank you so much, makes it much easier to differentiate between those disease now

[@MedicosisPerfectionalis]

I am happy to help!

[@Ayrtonjulian094]

I've already finish mi MD but i think just now i can call myself a MD indeed. Grattings from Paraguay! Please, do not stop making videos

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@wem3121]

Awww you're so funny and amazing teacher. Thank you a lot!

[@MedicosisPerfectionalis]

Thanks a million! That’s a great compliment. I am delighted 😃 I’ve just graduated!

[@wem3121]

@@MedicosisPerfectionalis Oh thanks for answering! It's really rare to have the doctor in KZbin answer you. And you're very welcome, you're actually saving my hematology module! Btw, can I ask you something unrelated? it's about QT and PTT. why do we need a witness for each patient? Why can't we just take references (say, 13s is the reference time) without needing to compare it ? Thanks in advance!

[@adin200]

Everytime I go on your site its like a Treasure hunt! Thank you!!!

[@marita5546]

this was so so so helpful, really appreciate the time you took to create this :)

[@MedicosisPerfectionalis]

You're very welcome! Would you please help me by sharing?

[@kalpanakarunakaran7033]

You are simply awesome and made it sooo easy to understand.just loved d videoooo❤️❤️😍😍

[@MedicosisPerfectionalis]

Thank you so much 😊

[@rachealarnold9711]

you made it so smooth be blessed!

[@MedicosisPerfectionalis]

Thank you so much 😊 You as well

[@haigpakhchanian4420]

Really filled in the gaps, thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@wafiaiman9544]

Because you explained it well, i just subscribe to your channel.. 'MANTAP' 👈Search for this word.. It's malay word.. It's describing your video as a whole 👍👍😁

[@darlenefalast9419]

What kind of genetic blood work does a hematologist order. Talk about that sometime please.

[@djalitanaful]

that was really helpful. thank you so much for sharing. this was such a good addition to the lectures i was totally confused. it has been very well explained.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@mubarakeleid6996]

Om Aldunia, Bhabk from Kuwait!

[@mouhamadeldarwich]

Are myeloproliferative disorders a larger umbrella that includes myeloproliferative disorders or are the two synonymous?

[@HR-vw2nd]

Woooow vielen Dank!!!!

[@atharvavankhande8906]

Why AML is not a myleoproliferative disorder ? And other u mentioned transform into AML?

[@divineunity7239]

thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@AngelaMoses123]

I like these Hematology videos! My family has unusual bone problems but there has never been any Doctor Who diagnosed anything in particular, but there continues to be unusual bone issues and hematology issues and I have been trying to learn about hematology so that I can know which test to request! So for the things I have learned have helped me to request the tests that have helpful and the abnormal levels help narrow it, but they still do not seem to fit into any specific category. I need to continue to learn more! Have you done a video on bone expansion, bone islands, teeth and finger nail abnormalties? These are blood factories correct? Something is causing these to be abnormal and there are other symptoms but they do not seem to fit exactly into any category. In me there seems to be iron deficienct anemia but there seems to be possible iron overload as well? I have always been Mycrocytic hypochromic and get sick when I get to much iron , I vomit and have menstrual like bleeding from iron or excersize and aleopecia worsens especially with added sun exposure. I have reduced unlimited the amount of sun for one month and not allowed bright lights and my skin is turning back to normal it had turned to bronze, my bone pain improved as well. It has not went away all together and I am still having pains in my organs. My youngest son shares some things such as constipation, and hand and feet pain, He had frontal embossing and at age 1 his new teeth began to turn colors and deteriorate. His blood work was opposite of mine, RDW low , MCV normal, MCH normal, rbc high, wbc high lymphocytes high, eosinophils high, basophils high. They seem equally high. My RDW is high, MCV low, MCH low. Even though our levels seem opposite we both have constipation from birth( his stool was normal when except when I breast feed him for three years because he did not tolerate formula) ( I had from birth, So we share constipation and pain in his hands and arms and I have pains in my long bones and and my hands arms and feet. Now that I am older my organs seem to be disfunctional and painful. Maybe we have a shared dysfunction with different alles causing different issues? Or one shared issue or mutation? and other seperate issue? I have other family members with so.e similar issues but but I will not complicate it more. So for me, I love the hematology videos because it seems to me that everything can be deciphered within the blood! In fact after learning so much about blood I wonder if cancer is not the results of something that was going wrong that was ignored for too long and that if we could have seen the imbalance in the first place and corrected it maybe cancer will not come? Thank You for sharing your videos! Angie

[@chicken2846]

Hello, how are you now? Any better? Any changes or tests confirming a diagnosis? ❤️‍🩹

[@chrisp7336]

MPN may no longer be just a condition for the elderly anymore, there is a certain population that develops the condition earlier on in their life

[@way2happiness400]

Can we take a screenshot of the vedio ?! And thanks for your help it's awesome

[@missdiamond7335]

U are the best always and know i watch this vedio 9.5.2024 Thursday for my last medicine exam at “six stage” and i may be i well back after graduation … too much thanks 🤍

[@MedicosisPerfectionalis]

All the best!

[@il3mendo]

Is the mthfr mutation involved in any of these myeloproliferative diseases ?

[@almash1417]

think you so much I wish my prof can explain this as good as you do

[@MedicosisPerfectionalis]

That’s a great compliment...Thanks a ton!

[@midnightriot2454]

Well then, I'm 29 and have been diagnosed with an MPN, that's why I'm here learning more about it, my consultant told me that my blood is basically like a 70 year olds

[@MedicosisPerfectionalis]

I am so sorry to hear that. It's true that the majority of MPN patients are old. But, it can happen at any age! Keep fighting the good fight, and don't give up!

[@jacksparrow-wq1pb]

Amazing video ❤❤ thank you.

[@lanavoliladygagu]

YOU MADE MY DAY. THANK YOU

[@MedicosisPerfectionalis]

My pleasure 😇

[@birhatyouns2004]

I Love you medicosis ❤

[@ZaidanyZ]

Great job. Thank you 🙏🏻 😊

[@MedicosisPerfectionalis]

My pleasure 😇

[@doctorofmedicine1113]

This is the only chapter which i understood well.. Cradiet goes to Medicosis .?. thanks

[@MedicosisPerfectionalis]

I am honored 😊

[@boutheynabou2060]

That's amazing , thanks a lot

[@Mariah-ge5be]

Best explanation👏👏 Thank you so much 💙

[@sairaali4334]

Your genius...lifesaver

[@MedicosisPerfectionalis]

Thank you so much 😊

[@janebryon4955]

Really useful video for training scientists. Could you consider an update including CALR and MPL? 🙂

[@MedicosisPerfectionalis]

That’s a good idea

[@nappingracez]

"some students are very suspicious because they are itchy after shower, they think they have it [PV]" - I AM DEAD HAHAHAHAHA

[@MedicosisPerfectionalis]

Haha 😂

[@travelceylon8613]

You re really smart 😰😰😰 thanks a lot 🔥🔥🔥🔥🔥🔥

[@MedicosisPerfectionalis]

My pleasure 😇 I don’t think I am smart! Thank you so much 😊

[@ugwuanyiadaeze4081]

is V617T same as G1849T? Do they both cause JAK2 mutation?

[@mirjampiko7624]

Hi thnx for all,i am from Albania i have 2 years that i have a high couNt of EOSINOPILS,I HAVE ALL THIS MUTATION NEGATIVE> FIP1L1 PDGFRA PDGFRB FGFR1 JAK2 BCR ABL,SORRY WHAT CAN BE MY CONDITION ?

[@sunrise3996]

actually you are Amazing Thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@rezamoradi7238]

Helpful

[@MedicosisPerfectionalis]

Glad you think so!

[@gabrielagonzalezescalante1063]

Great video ! Thanks !

[@MedicosisPerfectionalis]

My pleasure 😇

[@tgifford4]

What percentage of population with the JAK2V617F mutation do not go on to develop a myeloproliferative neoplasm?

[@lona9627]

Great 😍😳🔥

[@MedicosisPerfectionalis]

Thank you 😊

[@nurliyanazamzuri9364]

Thank youu so much for this video!!!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@dresmailqasem]

So good

[@MedicosisPerfectionalis]

Thanks 🙏 Can you please help me by sharing?

[@fatimahm9553]

How can all leukemias become lymphoproliferative ? For ex in acute myeloid leukemia the problem is in the myeloid linage?🙁

[@MedicosisPerfectionalis]

Not all leukemias are of myeloid lineage. Moreover, cancer doesn’t follow rules! It’s a disease!

[@sofiaahmed3872]

Thanke you ...You are amazing

[@riaias6882]

God bless ❤ only thingh I can say

[@MedicosisPerfectionalis]

God bless you too!

[@mustafaaljanabi3308]

Thanx a lot

[@MedicosisPerfectionalis]

My pleasure!

[@طائر-و6ظ]

Thank you ❤️

[@MedicosisPerfectionalis]

My pleasure 😇

[@noornoor-yv8tu]

Man u goooood. Thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@valsartanay7117]

Thank youu🙏🏻

[@dontlosehope3819]

thank you great vedio

[@MedicosisPerfectionalis]

My pleasure 😇

[@yaraemran1165]

You are extremely amazing good jobb

[@MedicosisPerfectionalis]

Thank you so much 😊

[@m0ony1]

Ty! Very informative vid

[@MedicosisPerfectionalis]

My pleasure 😇

[@noranfelemban3067]

Thanks 🙏🏻

[@MedicosisPerfectionalis]

My pleasure 😇

[@rembeck8549]

Thank you!!!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@indiabiologyexplains5013]

3:40 LMAO just came back from a shower and saw this

[@MedicosisPerfectionalis]

:)

[@ameterasu13]

where are the pdf notes?

[@MedicosisPerfectionalis]

On my website: www.medicosisperfectionalis.com/

[@dkatpar]

appreciated:)

[@MedicosisPerfectionalis]

Thanks 👍

[@arshadhussain8797]

Kindly make a video on mastocytosis

[@MedicosisPerfectionalis]

That’s a good idea 💡

[@majeed882able]

No Acute myeloid leukaemia in thrombocytopenia !

[@MedicosisPerfectionalis]

What do you mean?

[@IsmailKhan-tb2tw]

C option is right

[@MedicosisPerfectionalis]

I don't understand.

[@eimanabedalhameed6396]

I want the pdf

[@MedicosisPerfectionalis]

On my website: www.medicosisperfectionalis.com/

[@HamzaAfridi999]

Thank you 😊 you are the best

[@poojapal3537]

Is it cancer?

[@MedicosisPerfectionalis]

Yes! But manageable! Not all cancers are created equal.

[@Idowu_Balogun]

Suspicious and pessimistic students... Some actually came to ensure they don't have it 😁😁😁

[@MedicosisPerfectionalis]

Haha 😂

[@lillwolff2353]

I absolutely dislike all those interrupting ads, they are annoying and VERY loud.

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Pay for premium.

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Need help in phlebotomy? peruse "A Guide to Venipuncture Proficiency" on Amazon!

[@phateme.1119]

🙏🏼🙏🏼

[@MedicosisPerfectionalis]

Thank you 🙏

[@Roxy__12]

I have PV I think! 🤣🤣

[@manibaharestani9373]

😂😂😂😂

[@paediatricspotcases5220]

How do get premium video

[@MedicosisPerfectionalis]

Join my KZbin channel membership program to watch premium videos: kzbin.info/door/l-J-ovSJhA3or73Q2uVpowjoin

[@mirasoraya909]

The best lecture channel in youtube, thank u so much for sharing ☺️🙏🏻 Love from Indonesia 💕

[@MedicosisPerfectionalis]

My pleasure 😇 Thanks a million! Can you please help me by sharing my videos with your friends?

[@mirasoraya909]

Medicosis Perfectionalis my pleasure 💕, and off course I’ll share ur video to my friends 👍🏻 keep sharing, can’t wait for the new one 🥰

[@sarahabdallah3337]

negative feedback mechanism where you grew up?😂

[@Hk-iv6jq]

I loooooove the way you explain the subject.

[@alprincmalki]

My erythropoietin is normal is that mean my myeloproliferative is negative?

[@abod-v_o-]

but doesn't JAK2 work intracallularly, how doesn't stumilate the receptor form out side??

[@catherineportland503]

I live in Portland Oregon can you suggest someone like you they say I have et cythemia with jak 2. I acquired this after a forced stroke by a doctor. Chemo does not work for me I have been thru 3 oncology/ hematologist. None of them are educated on this. My platelets have come down some 1,029,000. Wbc not much increase rvc perfect. But immature granules are high. I feel I have not been diagnosed correctly 2 Dr's said biopsy last one says I don't need one. You seem to have smarts. Is mayo clinic or fred Hutchinson in Seattle. If I can fly and come back by night it doesn't matter where. Just want a research dr about my disease. Just like an opinion

[@vyshaliravatale7898]

Hi symptoms of mpn are

[@MedicosisPerfectionalis]

????

[@nnz652]

Thank you the best lecture❤

[@MedicosisPerfectionalis]

My pleasure 😇

[@مالكبنأحمد-ف5ث]

Can I get the link of facebook

[@RedBullxMD]

I'm in medical school and this guy is 10/10

[@MedicosisPerfectionalis]

Thank you 😊

[@SamuelMwene-hu4sw]

Boss wabonse

[@isuturehasti4266]

"where I grew up" looool we definitely grew up in the same place

[@MedicosisPerfectionalis]

Haha 😂

[@loyaltyesmaeel5656]

very good demonstration excellent work 👏👏👏

[@MedicosisPerfectionalis]

I am honored...Thanks a lot 😃

[@samxmatcha]

very helpful :) Thank you!