The Programming Language of Life? (TMEB #1)

There is a deep root of mathematics within biology. How this came to be, you’ll have to watch the video to find out
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[@N____er]

Pin for good channel luck

[@spectralvalkyrie]

That's cute :)

[@wiweek]

You just tricked me into watching a video about biology.... good job

[@Nanorooms]

I’m glad I did :)

[@birdbeakbeardneck3617]

more like about D.Es

[@philipm3173]

What's so awful about biology? You don't like to know how you work?

[@PXO005]

@@philipm3173 nah... It's just a lot of theory and for some people like me it's kinda hard to remember facts and retain it after the exam, while for subjects like maths or physics it's kinda easy once you get the logic. I'm not saying nobody should learn biology or anything... I have huge respect for people who are able to learn biology

[@NicholasRenotte]

Same

[@arturorosas2170]

It's not just 1 codebase, we have several services in the background, the main executable (the DNA of our cells) and the power support service (mitochondrial DNA). But when it is installed, it unzips several services running at the same time: The antivirus (anti viral, anti bacterial, memory cells, etc...). Digestive system, Kernel, and a long ETC... So the DNA is the program but compressed in an installable file (Conception), and for it to work it must go through a long process of decompression and assembly of the hardware that takes 9 months.

[@ADeeSHUPA]

@Artem Down ܢܿܝ̤ܣ نَيس

[@joonasmakinen4807]

Well said! Actually, it does not only take 9 months… It takes about 30 YEARS to complete all its assigned tasks and result in a fully mature human being, where the body and brain development has reached its all completeness and fullness. Indeed, praise God the Father for his Superior Architectural Wisdom!

[@electronicfootball9219]

Science just proves all the time that God is the author

[@elaadt]

Yes! Finally someone explains the mathematics behind biochemical processes. The cell doesn't have a mind that conscientiously tells it what to do. It's the concentration of the molecules themselves that regulates their own production and this is the mechanism. Beautiful video. Keep 'em coming.

[@monad_tcp]

the mind also doesn't have a mind of its own, its just information acting on itself, probably, that's the motif that all layers of complexity bellow it uses, to the quantum particle level.

[@zucc4764]

Yes! Knowing can also inspire awe just as much as mystery. I hate it when people mystify things and impose their own interpretations (such as "consciousness" which isn't even well defined) on phenomena and totally dismiss logical, physical mechanisms behind these phenomena.

[@drhasnainsikandar]

Actually cells also adapts based on its surroundings and environment. For example if stomach is starting to fill with becteria E. Coli the stomach cells began to change to intestinal cells because E. Coli inhibits acid production and nutralizes it with urease . So stomach cells began to adapt and changed to intestinal cells as an adaptation. This process is called "intestinal metaplasia". There is also "esophageal metaplasia" with similar anaolgy . Cells are as smart as you :).

[@prumchhangsreng979]

@@monad_tcp yes but that is not related to how stuff on molecular level work. Before our body or us decide to do anything, information must first go to central nervous system, that is the brain, and then the brain is like a function where it decide what to do with those information. Just like u said, information acting on itself. But stuff on molecules level doesnt have a central nervous system, there is no info acting on itself. It just happen because that is it physical property. But the way we learn at school is that it was taught like biochemical actually have a brain and know what to do

[@StephenGillie]

A set of chemical and enzymatic processes, mixed to maintain an optimal operating temperature for the chemical and enzymatic processes, among other things.

[@N____er]

Trust me, this channel *will* hit the algorithm. Superb thumbnails, narration, animation, captivating topics. Don't give up early!

[@MalikMehsi]

yes algorithm recommended it for me! It's great :)

[@lolsadboi3895]

:) precognition

[@OsvaldoBayerista]

@@MalikMehsi same

[@Technophobic]

Today was my day for the algorithm recommendation.

[@angryman9333]

It did

[@justindie7543]

Holy cow, you’re exposing the rationale behind what I’m doing for my PhD thesis, everybody forget this before I get scooped! Fantastic video!!

[@electronicfootball9219]

Science just proves all the time that God is the author

[@simeondermaats]

This has got to be the best video on biology I've ever seen. Superb quality (both in animation and in script writing), sleek style; fellow commenters, we are witnessing the birth of a giant.

[@Nanorooms]

Thank you for your kind words! I’ll keep pushing!

[@olzhasus]

Keep going, this playlist will surely be among the best on topics of math and biology!

[@Nanorooms]

Will do!

[@odinmoron-garcia8858]

As wannabe mathematical biologist, yest, there's a strong connection between maths and biology and not only in modelling with ODEs! Simetries, shapes, groups, graphs and trees, information ... awesome!

[@PowerhouseCell]

I really enjoyed this, we need more animated biology channels out there! As an educational biology video creator myself, I understand how much effort must have been put into this. Liked and subscribed, always enjoy supporting fellow small creators :)

[@Nanorooms]

Hello there! I’ve actually been watching you for a few years now! I’m pleasantly surprised to see you here.

[@a2bros186]

Now this is what I should have read when studying Genetic Engineering

[@yesnoidk]

this is so good for people with a math/programming background, i cannot understate how awesome this is

[@mystwalker479]

I've long waited for someone to compare biology to programming... as a programmer. Really good video!

[@ThePandafriend]

That's why in biology, especially molecular biology, there is A LOT of mathematics. However it's rarely overly complex. In 99% of cases it's basic school mathematics. Elementary school to basic analysis. Plus imaginary numbers maybe, but that's pretty rare and also not very hard. Many things can be predicted and that's also why in silico research (computer based research) works. Look up "bioinformatics" if you're interested in that (you can also study it, which I do right now). And writing code for that is not overly hard! If you know about if/else, for-loops and arrays/lists/collections you can recreate many systems. But it doesn't stop there, you can also dive deeper, depending on _what_ you want to do. But that obviously doesn't mean that everything is trivial. You need a lot of knowledge about the system in order to do effective research.

[@monad_tcp]

ironically, this simple equation in this video is already more complex than any math on economics class, its funny they try to model a complex system using linear equations. I refuse to acknowledge economics as a real science, I'm recreating my own mathematical models and simulations starting from scratch. someone might have done it, but mainstream economics is pure bullshit, and I really want to understand how to complex system works, not what the mainstream status quo think how it works.

[@monad_tcp]

biology on the other hand, is a proper science ! with proper mathematical methods ! loved it.

[@jackyjack9660]

and I'm here with adv maths in biophysics...

[@milopage2082]

This channel deserves a million subs. Crazy quality

[@mike_lupriger]

💯

[@Nanorooms]

Thanks! Will keep them coming!

[@manavhirani]

damn your channel is gonna go big in no time! such high quality production and research!!

[@jonathanodude6660]

I understand what you are going for, but i disagree that the maths explanation is required to understand why a protein would repress its own production. without a direct feedback loop, the cell would have to sense the amount of protein it produced with another system. this sensor system would also be a protein and its production would need to be sensed and controlled as well. for the sake of accuracy, each protein would need its own sensor protein which would require its own DNA to produce as well as control mechanisms to produce enough to repress the sensed protein by enough. in addition, this sensor would need to its consumption to be sensed as well as its production. the problem is clearly one of complexity, which leads to multiple failure points. the simple answer is that the sensor and inhibitor comes with the protein, so theyre produced simultaneously and in correct proportions. the ability of a protein to inhibit its own production negates the need for a separate sensor protein. this makes the negative feedback loop of "negative autoregulation" to be the most efficient control mechanism within a single cell. when we are talking about cell-cell contact or hormonal activation, the sensor (receptor) often triggers a number of responses, some of which are usually to downregulate multiple initial signals, sometimes including the receptor itself, depending on the frequency of the signal. looking at this problem through the same equations would yield different outcomes, however, the biological difference between communication and signalling is quite clear. I think its a bit inaccurate to say that the mathematical description of the problem is the only way to intuit the solution, as the biology of the issue is quite self explanatory and the solution still requires a biological understanding of what is occuring.

[@tilibomtilibom4656]

There is a section that a little bit confusing: at 8:00 you are talking about changing X, but diagram shows changing of b, then you are talking about changing b, but showing changing n - had to rewatch it to understand what is going on. Also it is hard to hear you at 9:54 when music is starting to play too loud (it was a problem in previous video too) Otherwise it is a great video, thank you very much, hope to see more!

[@AA-gl1dr]

Tremendous content. You’re still in the algorithmic lag phase before you get some exponential growth. As a molecular biologist trying to learn how to love math, I loved this video and immediately subscribed. Have been going along a learning chain on this topic for the past few days(months to years really) and the algorithm has been central to finding new topics and information. That just means your channel is being recognized and recommended to ideal viewers by the algo. Definitely checking out the rest of your videos and super happy I got this video in my feed. (Long comment for algorithm luck)

[@justindie7543]

Are we the same person? Doing my PhD in molecular biology. We should collaborate before you scoop me.

[@AA-gl1dr]

@@justindie7543 definitely open to collaboration across any and all avenues. I’m yet to enter my PhD but definitely headed in that direction. Would love to chat about things and hear your experience thus far in your doctorate!

[@brandonheaton6197]

This video was a very good introduction to the concept of computational biology. Your decisions of when to introduce what vocabulary were all well conceived and executed. Keep going. You are doing a wonderful thing here

[@dr_bean]

I love how modeling biology can be as simple and elegant as this. Keep on the good work! Cheers

[@xerzy]

Here before this blows up 👀 A shame I'm still not even good at basic calculus, but the previous video's notion that molecule interactions act as logic gates was wildly valuable already!

[@mrmadmaxalot]

This is a really good concise summary of what I was only able to find before by watching lectures on systems biology.

[@eff700]

This video is absolutely fascinating, thank you for bringing it to my attention this evening

[@Kraft_Funk]

Beautiful animation, beautiful topic, beautiful explanation. 1000 subs is a shame, but thankfully the algorithm seems to have started doing its job. Cheers!

[@infocentrousmajac]

Awesome content and very valuable. 3 years I have been following logic gates and multiple feedback control loops. Thank you for posting.

[@lukedowneslukedownes5900]

Super rare channel I’m glad popped up. Amazing super summary of the central dogma Btw. It’s very rare to find someone who can explain something in a polymath type of way 🙏 I love the black box summary you give thank you

[@jorge-lp2xi]

You just won another subscriber with just this video. Keep up this good work!

[@deadwalking100]

Thank you for such a great insight and informative video.

[@joo5070]

Wow, that's really amazing! Keep doing more of these, pleaseee

[@arin_rin]

Thank you so much for this,I'm working on a project just like this and you definitely gave me some insight into what I missed

[@dreandro458]

ive always wondered the same things, thank you for making this!

[@ppsocal4596]

One of the best intro videos explaining mathematical biology for beginners!

[@jebjosh369]

Great video! You might already be planning to do this but adding time delay to this equation and the subsequent oscillatory behaviour could be a good addition to this series!

[@olinuxx]

So good to see new STEM channels on YT! Great work, keep it up!

[@catalin7750]

The algorithm hit! Great video and keep up the good work!

[@Supervale111]

Man. Man. I'm studying psychology and this just... I'm speechless. Very great work! 🔥🚀

[@Ortorin]

Yes, please! More of this! Make sure there are good visual representations for laymen like me. This is some really cool info!

[@Moonlight-sj7qc]

I'm glad i found this channel the content you making is unique and very informative & worth a sub. A small suggestion share your channel of reddit programming subreddit and Hacker News you will get more people who interested in watching this amazing content

[@ashzm7949]

Wow such amazing content, as a biologist I always love to have a deeper understanding by knowing the math behind the different biological actions. So insightful 👍👍👍

[@kathrinm2420]

Omg, it makes me really motivated to keep learning programming!

[@weylandyutani4254]

Paper at 4:48 is "Negative Autoregulation Speeds the Response Times of Transcription Networks" Fantastic video.

[@GS-zx1kk]

nice animations man, youre doing great work

[@residentofthisearth]

Really good video. I am very new to mathematical biology. However, with this particular example, you have done a really good job in making me understand the importance of mathematics in biology. Thanks!

[@codeblue3228]

Amazing content, More of this please 💚💚💚

[@AJ-et3vf]

awesome video! Thank you!

[@zandijian]

May the algorithm smile upon you, great content, keep it up!

[@tylerheldreth4565]

Excellent video!

[@keithusurper4036]

This is a phenomenal content!!!

[@jeremyregamey495]

Keep doing those videos… I wanne learn more

[@gigishankulashvili2050]

I hope u will continue❤❤❤

[@yassen6331]

This is fascinating

[@tronche2cake]

I've been learning about cell biology and programming lately, I'm glad I'm not the only one who feels like biological life is similar to a program

[@NotABean_]

damn I've always wondered if DNA and life itself uses a 'programing language' so to speak, it really is an interesting topic! I really hope you make more videos like this

[@ZeleonScience]

Love this video! I'm studying as a bio major and math minor (at UBC as well!), so time to start binging your channel hahaha

[@kiaxarmlk]

Appreciate your that teach us this cas

[@dineshkamnani]

If you are making more of chemistry videos, I am definitely sticking to this :)

[@jawadoumar]

I am a med student and you killed it dude. You are super smart. Wishing you very good luck going somewhere with this research. I am probably gonna use some parts of this video in my next presentation. Hehe

[@YouMeverse]

this is very new to me. i liked it

[@travism7585]

Perfect video at the perfect time. Also from BC. you got my subscription.

[@siobudc-1711]

Thanks for video ! I'm French and I love your content.

[@ribamarsantarosa4465]

SEMA students (especially computing): 4:11 Negative auto-regulation (NAR) simplest network motif, how it works (4:21 a protein can be its own repressor) should be enough to make should give a straightforward notion of

[@sectorrrrr]

i do poorly with math and biology but i could somehow still follow along o

[@TheTwistedTraceur]

i like this so much, might as well show this to my teacher of programming

[@finnmorgan481]

this video was great, thank you.

[@jeremyregamey495]

Amazing video🤯

[@lock3399]

Cool visuals

[@piccoliadventures]

I love All information about this ❤

[@mateusnicolinibezerra9757]

This is brilliant

[@LookiePookie]

this video was very well made :) i enjoyed it

[@xandr1922]

Really cool video

[@ammarshahzad9627]

Great man, I was always facinated about biology. Mainly my questions were why does a zygote give birth to different type of cells when cell theory says cells can only produce their own kind of cells, and how cells communicated; how does body know to produce this many cells etc. I was able to find the answer to first one. Your video gives the answer to the latter. I am now doing engineering but your video showed me how I can integrate these two fields. Thanks mate, expecting wonderful things from you.

[@greyrabbit2157]

Finally! Original content on youtube!

[@randomNOMEN]

wonderfull animations of proteins.

[@petevenuti7355]

A series! Subscribed. Fan't wait to you get to morphospace and the electrical interactions ect between cells as that's the next level of abstraction above protein regulation and still you're not even to brains yet

[@sanan_fataliyev]

thank you. and spend your whole life on this research. considering the fact that your are an organism, the thing you are doing is ultimate meta.

[@harshyadav483]

Being a PCMB student I affirm that this video is absolutely accurate

[@ShinBaaaka]

seeing some numbers flying across the screen and a friendly voice trying explain me something I'll never understand my favorite type of content

[@nutzeeer]

5120th subscriber! I think you might be at 100k in a week.

[@wisdomenigmainc9583]

cool idea .. your apporach is quite impressive . i will like discuss with you over the topic

[@tomfillot5453]

Oh boy, just the topic for a youtube channel that I want to see. If you're ever interested in proof reading or interviews or writers or whatnot, I'm part of a whole network of labs of epigeneticists trying to bring math models in our study of gene regulation.

[@Nanorooms]

Of course! May I have your contact information?

[@Nanorooms]

If you’re not comfortable with sharing your contact information here, this channel’s email is [e-mail]. I would love to get in touch!

[@sph0]

I'm a simple man. I see cool new biology channel, I press subscribe.

[@gigishankulashvili2050]

DOOOO MOREEEE VIDEOOSE UUU AREE AWSOMEEE WOW I WAS THINKING ABOUT THAT TOO ...

[@deepdude4719]

You are my favourite channel right now in the whole platform. If I tell you that creation is a massive massive computer and there is a way to hack it up would you believe me??? Please keep uploading. You have an amazing content.

[@BartdeBoisblanc]

6:30 Funny you should mention a lump model. Those are often used in electronic to approximate a circuit with composite characteristics. like a Head phone speaker of a piezo electric crystal mic.

[@binaryalgorithm]

Wow, good way to get technical people sucked into the wonder of biology!

[@karolkornik]

Dude, keep it up!

[@thejackkk]

super interesting! i hope you will end up talking about systems biology. what software did you use for the 2D and 3D animations?

[@benarmstead9141]

You just tricked me into watching a video about math … good job

[@erenoz2910]

hey, i think you would benefit a lot from control theory! i'm an ee student who's interested in robotic controls, and this is very similar to what we deal with in our classes and workshop.

[@IN-pr3lw]

Thanks for this

[@MrChaluliss]

A little rushed through the last third of the video or so, but otherwise a good explanation of these phenomenon with very expressive graphics. Good stuff! I would suggest pacing things out just a little more carefully and letting the natural rhythm of your thoughts breathe in the future.

[@billymonday8388]

mate your videos are really nice and they showcase the similarity we can exploit between genetics and software. BUT please normalize the sound of the videos. I have to turn up the volume a lot to hear you. You can do this in audacity, in the effects tab!

[@lopyus]

Interesting video, thanks for making😄. Can you recommend any books/online courses for learning more about this? I am a math&cs major btw, so I've got that part covered

[@nandanreddyp]

nice topic

[@MaanMH]

Amazing!!

[@brycekoop]

Great thumbnail and awesome video, may I ask what you use for animation

[@lachlanperrier2851]

Absolute top tear vid

[@scrambo6182]

People have been so focused on aerospace and engineering and computer science for the future, which they're right to do, because those fields are booming, but over the next few decades, molecular biology, biotechnology, biomolecular sciences etc. are gonna go CRAZY. Nanomedicine is just the beginning.

[@rajinfootonchuriquen]

I think the problem of activity given concentrations is kinda easy in the sense of math. The big problem is: given a sequence of nucleotides, what are the proteins it can produce? Obviously are sequence of transciption start with MET, but after the transcription, what is the correct folding of the protein and how interact with other tissue or structure? Untill now, genetist need to switch on and off a gen to speculate what the protein code by that gene is doing