New MDMA! (Bioisosteres)

[@chemistrycapital]

We are back! This video took longer than I hoped but wanted to get it right, especially with the upcoming decision by the FDA! Let me know what you think below.

[@christopherleubner6633]

These chemicals might have a mdma like effect but if it is oxidized to the acid by MAO it is likely that some enzymes might mistake it for phenalanine, but be unable to connect it in a peptide string terminating the biosynthesis.

[@fukpoeslaw3613]

You said that these molecules could have less side effects because they're 10 times less potent. I don't get that because if they're 10 times less potent, then you would need 10 times as much of it, right? And then side effects would, at least could, become 10 times stronger as well. On the other hand, when you've got a molecule that's say a hundred times stronger, then the side effects that don't work via the main receptor would likely be a hundred times less severe. Am I making sense? And if not, please tell why. Thank you!

[@fukpoeslaw3613]

. Test1. Were you able to read my (other) comment? (Cause my comments keep on disappearing. Since months, years even!)

[@fukpoeslaw3613]

I came to say that I can't see two other comments I sent earlier to this spot.

[@chemistrycapital]

@@fukpoeslaw361310 times less potent at receptors that are thought to cause some of the side effects (5-HT2B for example)

[@FloydTheBreathless]

Damn. We got new MDMA before GTA 6

[@chemistrycapital]

😂

[@FloydTheBreathless]

@chemistrycapital I have tried a ring substituted MDA derivative. 5-APB. Supposedly non-neurotoxic due to it not being converted to alpha-methyldopamine. Was very similar in effects. Used to buy it online before the UK psychoactive substance ban

[@MichelleAtkinson-k2l]

Me too 😊​@@FloydTheBreathless

[@Allen-r5x]

​@@FloydTheBreathlessI thought it was 6- APB . or maybe that was just another research chem. Whichever ,i used to do allot of it here in the US.

[@mikaellindqvist5599]

@@FloydTheBreathless Theres studies that seems to prove otherwise. New substances are new and less known. Unknown dangers aint the same as less dangerous.

[@InspectahPatio]

Like others have said, I too was extremely suicidal and there was almost no light left in anything I did. I decided to do MDMA with a close friend and we intended for it to be therapeutic. I really believe it saved my life. Living with years of depression, you almost forget what it is like to be happy, to the point where it subconsciously doesn't even feel possible. MDMA reminded me what it was like to be happy, but more importantly, that I had the capacity to FEEL happiness still! I don't see it as a treatment, but more as a very powerful tool that should be utilized responsibly.

[@bepowerification]

Had a similar experience. Took MDMA 2 times in my life and the first time I felt good for over a year and my dysthymia was gone.. 20 years later I still remember how MDMA opened my eyes and helped me see how good my life actually is and that me worrying and being sad is absolutely pointless and without reason.

[@cvspvr]

wake up babe, new mdma dropped

[@chemistrycapital]

😂

[@eurohulk6515]

at least MDMA has been proven to be relatively safe with millions of people. Whereas a novel analogue might have unexpected side effects

[@cvspvr]

@@eurohulk6515 time to publish pihkal: 2nd edition

[@thesupreme1503]

@@eurohulk6515 not really there are countless studies indicating its exceptional neurotoxicity due to free radical generation in serotogenic/dopaminergic neurons, whose numbers dwindled up to 90% and took 7 years to restore 40% of neuronal loss

[@BraydenBomb06]

@@eurohulk6515Heroin has also been researched heavily and we know it is physically safe and mentally fine in moderation.

[@lrwiersum]

All I know is that MDMA cured intrusive suicidal thoughts for me 6 years ago. I was DANGEROUSLY suicidal. Haven’t had suicidal thoughts or depression since.

[@biomassmoth]

Holy heck I mean I have had episodes of suicidal depression but if it can cure it then I wish I have had it back in my day

[@plasmavortex5388]

Ketamin is way better and safer in my opinion

[@spaceghostmiid]

@@plasmavortex5388 this is demonstrably untrue. mdma is slightly neurotoxic when used too often. in a medical setting it is going to do basically zero harm. ketamine is not only neurotoxic with prolonged use, but also causes kidney and bladder damage. both are miracle drugs for depression, but ketamine is 100% more dangerous unless we're talking about the treatment of someone with cardiac issues.

[@bridgetsieger2261]

From a Dr ? How did you do this?

[@thomasrussell4674]

Was it a one off experience with therapy, or a course of sessions?

[@JagoSma-s3u]

I've taken MDMA and had shrooms. MDMA a few times, and completely laughed my a** off, which my sides hurt for days lol. Shrooms only once and I experience what I was hoping for. Now that's not saying it doesn't cause I have friends that say they've had amazing experiences on shrooms.

[@Dain23]

The insights I've gained from magic mushrooms have been invaluable. They've helped me understand myself and the world in a new way.

[@Lorelei-z9h]

My experience with JMF was a whole new dimension and I saw the future of humanity. I saw aliens and it felt like I embodied the universe. It's beyond explainable.

[@Demirci-g9]

Mushrooms are packed full of an important antioxidant called glutathione.

[@emmabless6647]

Glanced around for a while now but I've not gotten my hands on it, how do you yours ?

[@typer6678]

no one asked retard

[@44davewright]

This is classic big pharma move, MDMA is no longer able to be patented so get its use blocked in favour of "new" version that can be patented and sold for exorbitant cost.

[@lrrrruleroftheplanetomicro6881]

Only these studies come courtesy of public european institutions.

[@JonnyParker-]

And I bet they will change the formula so it makes your infertile or gives you some other turbo cancer for public use .

[@jhonbus]

I mean... That's certainly _a_ way of looking at it. I've not followed the literature on MDMA for a good decade+ now. Back then there a couple of papers suggesting potential neurotocicity in MDMA, I don't know whether this ended up being confirmed as a serious issue or not. Given MDMA has been given approval for several trials worldwide I'd guess it's still considered reasonably safe. But any research into improvements and analogues is absolutely worthwhile, I don't think it's reasonable to ascribe some sort of evil motive to doing such. If a company can claim legitimately that their new patented version is superior then it seems logical to use that in preference to the original, no? I can see the concern about "getting MDMA blocked" in favour of novel analogues and sure, in places like the US where public bodies seem almost infinitely corruptible, that could happen. But there are medical and research bodies all over the world that aren't so susceptible to malign influence. In any event, I can't see MDMA or any of its analogues becoming much of a money spinner for manufacturers, even if they _do_ hold a monopoly on supply - it's just not going to become a mass-market product any time soon. And besides, I'd be _very_ surprised if all these bioisosteres haven't turned up somewhere in the literature in the last couple of decades. It's a fairly obvious thing to try.

[@Futt.Buckerson]

​@jhonbus Absolutely this. Of course, modern researchers are going to attempt to find way of reducing the negative effects of a drug. And that will come with patents to pay for the research. And all of that aside, if the new drugs ended up being better than MDMA, I'm sure the folks supplying the MDMA would figure out how to cook the new stuff. 😆

[@haraldhimmel5687]

@@jhonbus Neurotoxicity of MDMA is still a bit controversial. There are certainly good reasons to be careful with it considering that uncertainty. It is pretty much seen as a calculated risk in a medical setting. All medications have up- and downsides. Not just MDMA. There are some compounds out there sold OTC that kill thousands of people per year and nobody bats an eye. The best example that comes to mind, Aspirin. I really don't think a hand full of MDMA induced therapy sessions would be that big of a deal in terms of neurotoxicity considering the severity of PTSD and related conditions.

[@benmcreynolds8581]

Some might find this stupid but No joke out of all the experiences & experiments I've done, the One I would choose is: Everyone should get to experience MDMA once in their life! Because of multiple things, it can let someone with crippling anxiety at least experience one moment of their life where all that kind of goes away. So it allows someone to get past certain things they might have otherwise never gotten past in the first place. It's a beneficial perspective shift. Also I experienced a lot of stress & trauma around me growing up and I had no idea how helpful MDMA would be but it felt like it let me face certain things and rearrange them in my brain so the stress & anxiety no longer got in the way nearly as much as it used to and it helped me start continuing to further work on healing past crap. I just think everyone deserves to experience that or something similar to that once in their life.

[@TjallieBrrr]

I have add/adhd, molly doesnt work or do anything to me (besides looking like i smoked meth) and i had the same batch for years, many people used it and worked fine for them. Same with amphs, always found that interesting. The one time i got geeked off molly was when it was actually meth, didnt really like it but the house was spotless lol

[@biomassmoth]

Nah I'll pass on the comedowns, not for me, even though I some what agree

[@benmcreynolds8581]

@@biomassmoth I totally understand. I was just talking from the point of view of, if someone drinks they experience a shitty hangover.. So even tho there's a recovery period afterwards I think MDMA is still a worth while experience. It's much better than getting hooked on opiates. Trust me I had to go thru that. So even tho there's a come down, it's really not that bad. Especially when compared to many other things and the experience of trying that substance is better than most other ones. That's all I was saying

[@The3rdPlateau]

@@biomassmoth I've found that as long as I purity the MDMA myself, and only take it once a year... there isn't really a comedown at all. In fact, there's actually somewhat of a lasting afterglow! But one other thing that helps a lot: Make sure that whomever you're rolling with stays with you until the effects are completely worn off. It would benefit both of you quite a lot. The comedown is often just a symptom of loneliness I've found

[@lillia5548]

@@TjallieBrrr thats intresting, I also have adhd and it worked for me although it wasn't stimulating it calmed my brain like adhd medication would but I got all the other effects

[@themrjones]

That shit fixed my PTSD 100%. Once you start blowing up you just think of the trauma and then after that your brain associates it with the past. Instead of thinking of your trauma like every single day and it really messing with you you'll think about it like once every like 4 or 5 years and then after like the second or third time you think about it , you'll just never think about that shit ever again. It's so amazing. Edit: One thing is every time I see a story like this about it treating PTSD it makes me think of my PTSD but like it doesn't bother you not one inkling it really does work

[@SecretSoundSociety]

Fed trying to set up an ex military, gets no more scummy @Nancy-xc5os

[@anasofiaas]

Thank you for such a clear and straightforward explanation of our study in your video! As first author of this study, I thank you on behalf of the whole team!

[@chemistrycapital]

@@anasofiaas Wow, that’s amazing! I never thought the people carrying out this research would actually find the video. If you want to use any material from the video, just give me an email and I’ll send it over!

[@anasofiaas]

​@@chemistrycapital thank you! I'll reach out to you if that's the case!

[@Lukesab3r]

This is gold! When human trials begin, i volunteer as tribute.

[@GeM-pr8xm]

mdma is safe enough for therapy. there are people out there who struggle with life. it can re-open up oneself to a life worth living.

[@DoraMuitama]

Psychedelics have been the actual true remedies that eased my depression, ADHD and anxiety,have got entangled with this dude who shoots mushroom and other psych safely to my location with no hassle

[@DoraMuitama]

Hj_hyxaez

[@completelytransparent6320]

@@DoraMuitama deek suk mudda fuk oogala boogala SPLEEN REEVVVEEEERRR BEANS

[@Henninchs]

Yes, and therefore it's not acceptable to wait longer. If there will be a safer or better tool in the future - great. Anyway, letting people suffer now for the interest of companies to release a similar product.... is not acceptable

[@Zach______]

@@Henninchs 100%

[@dylanthedyslexicvillain4294]

Taking MDMA in the 90s for me was life changing I was painfully shy and never enjoyed going out always felt unconfident and as though I never fitted in, but going to raves and taking pills in the 90s. was just amazing I was the most confident person in the club. I just walked around shaking peoples hands and getting hugs. It was truly amazing. I have 10 years of this and thoroughly enjoyed it. Wish I could go back and relieve it unfortunately it didn’t change my confidence when I wasn’t high. I still find it painfully shy going into pubs and clubs unless I’m high, now unfortunately I take antidepressants and ecstasy does not work when you take these type of antidepressants , I do think that MDMA has medical benefits but it also depletes your brain of serotonin which causes depression that the amount used in therapy wouldn’t be anything like the amount of people taking clubs so the amount of serotonin would be greatly reduced in a medical setting. this year in November I’m going to pick mushrooms and hopefully they will work better at helping with depression.

[@haraldhimmel5687]

Actually in a medical setting a well sized dosed would be around 150 mg iirc which is indeed close to the optimum of what people do in clubs but if you dont do it too often the damage should be minimal. BTW, mushrooms don't work with most antidepressants either, sorry to say.

[@timogden439]

It's true. Psilocybin is really close to serotonin and the ssri basically just renders it useless. Believe me I have been trying to teip for months. I'm quitt8ng my ssri to see if shrooms work for me again in the future. I saw that they block Psilocybin for up to 3 months after you stop tak8ng them. Good luck in your travels. I'm looking into benzos next, specifically klonopin.

[@dylanthedyslexicvillain4294]

@@haraldhimmel5687 oh that’s really a bummer I didn’t know that about mushrooms. I was going to go and pick some when the season starts, bloody anti-depressants damn things don’t even work that well think I might come off them LOL

[@haraldhimmel5687]

@@dylanthedyslexicvillain4294 Thats a drastic step. Take care.

[@rileyludwig1338]

MDMA cured my social anxiety and depression almost completely when I was taking it semi regularly. Would love to see this chemical refined into a working mental health medication. I have PTSD anxiety and depression. I’ve been on many SNRIS and SSRIs and nothing has worked better than psilocybin mdma and therapy.

[@MattyEngland]

For anyone reading this, worth noting that taking MDMA with SSRIs is super dangerous. Do not mix the two. If you're going to try MDMA, you must get off the SSRIs for quite a few weeks beforehand.

[@Zach______]

The holy trinity. I would add ketamine assisted treatment.

[@interstellarsurfer]

Classic 'add a flourine, patent the new compound' shenanigans.

[@chemistrycapital]

Haha, look up DFMDA

[@hammerth1421]

To be fair, it is pretty much the ideal solution for oxidizeable hydrogens that you don't want to be oxidized.

[@christopherleubner6633]

Yup they are good for doing that.

[@AleChemist23]

@@chemistrycapitalas a drug designer I just can’t wait for deuterium dederivatives

[@RinceCochon]

Yeah, el famoso fluorine-substituted amphetamines, it's like fckin pokemons x)

[@Evilepter]

The Interaction with 5-HT receptors causes mild psychedelia, which is important, for the breakthrough experiences. These new molecules will have a dumped down effect in comparison I'm afraid. APB analogues where much more promising in that regard.

[@haraldhimmel5687]

Well I guess they will have trials that are inconclusive and then its another round to introduce MDMA again.

[@SerhiiVoin]

The mild psychedelic effect is certainly fun, but also these activation of these receptors are toxic to the heart, especially 2ht2b It's better to skip the heart attacks and sacrifice the psychedelia.

[@Evilepter]

@@SerhiiVoin it's mainly toxic when used often in small intervals. The body can handle occassional usage of moderate doses just fine

[@haraldhimmel5687]

@@SerhiiVoin Is there any evidence that occasional MDMA use causes heart attacks in a medical setting? Do you know what we do have evidence of? To cite a paper: Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro . Abstract The "club drug" 3,4-methylenedioxymethamphetamine (MDMA; also known as ecstasy) binds preferentially to and reverses the activity of the serotonin transporter, causing release of serotonin [5-hydroxytryptamine (5-HT)] stores from nerve terminals. Subsequent activation of postsynaptic 5-HT receptors by released 5-HT has been shown to be critical for the unique psychostimulatory effects of MDMA. In contrast, the effects of direct activation of presynaptic and/or postsynaptic receptors by MDMA have received far less attention, despite the agonist actions of the drug itself at 5-HT(2) receptors, in particular the 5-HT(2B) receptor. Here we show that acute pharmacological inhibition or genetic ablation of the 5-HT(2B) receptor in mice completely abolishes MDMA-induced hyperlocomotion and 5-HT release in nucleus accumbens and ventral tegmental area. Furthermore, the 5-HT(2B) receptor dependence of MDMA-stimulated release of endogenous 5-HT from superfused midbrain synaptosomes suggests that 5-HT(2B) receptors act, unlike any other 5-HT receptor, presynaptically to affect MDMA-stimulated 5-HT release. Thus, our findings reveal a novel regulatory component in the actions of MDMA and represent the first demonstration that 5-HT(2B) receptors play an important role in the brain, i.e., modulation of 5-HT release. As such, 5-HT(2B) receptor antagonists may serve as promising therapeutic drugs for MDMA abuse. So there is a good chance that if you get rid of 5ht2b or 5ht2 in general, that you will have a dud. There is no psychedelic therapy without psychedelic effects. The MDMA experience is vital in therapeutic sessions and MAPS has proven that it works relatively safely. There were other candidates, such as 2C-B but the people at MAPS were convinced that the benefits of MDMA outweight the negatives (and uncertainties 2C-B may have since it isnt as well researched). This new compound has that problem too. We know next to nothing about pros and cons of that chemical. We would throw away decades of research and start over with a novel compound.

[@Trtko-y2p]

From the study on rats "Dextromethorphan (anti-cough syrup) have been reported for its protect effect on methamphetamine-induced neurotoxicity, it remains unclear whether Dextromethorphan has neuroprotective effects against MDMA-induced damage in cerebral SERT changes."

[@Leidse_gap]

Yoo, i have never seen a video where literally everything in depth corresponds to my study biofarmaceutical science in the netherlands. The flow of the video is really good and neat. Explains everything just enough for me to understand. I'll be watching some more of your videos in the coming weeks. Keep it up man! Ggs 🙌

[@chemistrycapital]

@@Leidse_gap thank you so much! Planing to post more videos soon.

[@buriedpet]

This is a perfect example of why drugs should be legal. Imagine how many breakthroughs like this are just waiting to be discovered. Edit: Lots of really stupid people in my replies. Thank you to the smart ones for keeping my faith in humanity alive.

[@chemistrycapital]

This is one of Hamilton Morris main points

[@zalmanfans1334]

And i mean hell less kids overdosing with fake drugs when they csn get their hands on a Mdma Script haha .

[@arlobubble3748]

If MDMA was readily available, there would probably be less interest in developing analogues like these to get around its stigma

[@solvated_photon]

Yeah, except the “bath salt” analogs have been associated with severe reactions such as eating other people’s faces, reminiscent of PCP anecdotes. Do we really want to legalize everything?

[@The3rdPlateau]

@@solvated_photonThere's a very high probability that these scare stories are the result of severely overdosing on drugs whose effects would be much more stable, even enjoyable, at lower doses. In addition, the anecdotes we speak of are usually the result of the *worst* possible outcomes, which are typically quite rare, but when they do happen, they get over-publicized. This is contrasted with the likely vast, "silent" majority of users of the same drugs, who don't end up having public freakouts, and use in the privacy of their homes. We never hear about them because they maintain their privacy, but they're almost certainly the majority.

[@cosmophobia1917]

Reduced binding at 5HT-2a might greatly reduce the antidepressant and antitrauma/anti-ptsd effects.

[@ricardasist]

This

[@maximood-tired]

Finally they released MDMA 2

[@AdamAli-le7xb]

Before GTA 6

[@JonnyParker-]

I thought 2cb was mdma 2.0 ?

[@BierTK]

​@@JonnyParker-it's completely different, for me 2cb was more like LSD than MDMA

[@JonnyParker-]

@@BierTK yeah its crazy , much more intense and rushing all the time compared to md.

[@BierTK]

@@JonnyParker- Bruh, I'm now in love with Ketamine, watching Ricky and Morty on closed eyes where 1G I've got lasts me for more than a week now is crazy. But the visuals, another world. And it's even more bumped with the music you like.

[@Quartization]

Are we just gonna ignore the existence of non-neurotoxic benzofurane analogues that already have a history of humane (ab)use?

[@chemistrycapital]

These are also interesting analogues!

[@buriedpet]

Whoa could someone throw me some literature on this? I’m not familiar

[@matthewsoules7064]

​@@buriedpetnews to me as well.

[@YunxiaoChu]

.

[@lavadax2]

Tactical dot!

[@IngridUterus]

I took MDMA for years and have no negative effects. I love this drug. It makes also not addicted and has the best effects of all drugs IMO

[@bladee512]

Why are they trying to not allow the MDMA analogs to bind to 5-HT2 receptors? Woudnt that litterally just make non halucinogenic MDMA aka meth but really strong and with alot more tolerance build up?

[@chemistrycapital]

There is some evidence that drugs that bind to 5-HT2B can cause some cardiotoxicity issues

[@DawidEstishort]

While -2A receptor subtype activation might be usefull for it's efficacy, activations of -2B -2C and -3 are generally undesirable.

[@bladee512]

@@chemistrycapital Yes but what i mean is that giving someone a BIG HAPPY doesnt treat PTSD and most research on classical psychedelics shows that it helps treat trauma so im questioning the point of making it not bind to 5-HT2 receptors since thats what classical psychedelics do. (when i say classical psychedelic i mean any psychedelic excluding NMDA antagonist and k-opiate agonists)

[@victornica4225]

no. meth has much lower sert:da ratio

[@321tryagain]

2a agonism is not what separates MDMA and meth, the distinguishing factor is the serotonin:dopamine ratio

[@DuhYaThink]

MDMA could change the world. If pure and not abused,which would be difficult for many people. It is a beautiful experience. But not for everyone and should be used along with therapy and heavy monitoring.

[@TheeMuseumofjunk]

Therapy: Basslines Monitoring: Sweaty club

[@janemf]

lol ok

[@DuhYaThink]

@@janemf Have you taken pure MDMA before?

[@janemf]

@@DuhYaThink lol i used to buy it ten grams at a time

[@DuhYaThink]

@@janemf Damn 😅

[@Curu1]

At least the 5ht2a receptor agonism has been shown to be a very important part of the effect of MDMA and the thing that sets it apart of other substances that have more of only a recreational or euphoriant effect and way less of the therapeutic effects. I don't know about the 5ht2b agonism but I'd be pretty sceptical about these types of analogs, it's rarely so simple that you can just isolate the "negative" effects from the "positive" so easily as chemists or doctors seem to think.

[@harrisfrankou2368]

It is brilliant without abuse for trauma just brilliant. The key is without addiction. Immunity and tolerance to MDMA is quick.

[@valentinkugler9189]

thanks for touching on the assays used to measure activity! this is exactly what im interested in

[@bubat030]

I have thought about quinoline and quinoxaline bioistosteres of MDMA and other entactogens before, mainly because they would evade the the german NpSG, but besides of the cool selen isoster, this study is rather dissapointing. I believe 5HT2b agonism is actually responsible for inducing reverse transport at plasmalemma monoamine transporters and, having spend many hours docking, scoring and MDsiming different serotonin releasers at 5HT2b, these isosters don't look very promising to me :/

[@YunxiaoChu]

Hmm

[@RyRy-m9c]

Nice analysis. Sorta actually understand what your saying...

[@Andy101-tm3hz]

MDMA is classified as a psychedelic and empathogen according to the dsm Manuel

[@bubat030]

@@Andy101-tm3hz the term empathogen is kinda aged and David Nichols prefers entactogen. also the DSM has received lots of criticism in general. the classification as psychedelic on the other hand is fitting and I've already heard people complaining why it isn't used much when talking about MDMA :)

[@Andy101-tm3hz]

@@bubat030 The DSM definitely should be criticized because I believe alot of it is made up including many of its labels

[@dolphin265]

I'll be on board if the neurotoxicity and dysfunctional binding of alpha synuclein is fixed as a result of these new substituted analogs

[@aj9485]

neurotoxicity with mdma is so real. When you have 0 tolerance and use it, you can clearly feel burning overload of serotonine. Problem that MDMA creates way too much than its required... This all extra makes lots of damage in the brains... Not every person can recover from it. Some end up with scizoid personallity for the rest of their lives..

[@Bananakid11]

It's super nice that research is more common these days and we now can use the help modelling software as well. Makes sense, that MDMA itself ist just the beginning of a new path on understanding and fine tuning this specific type of interaction and effect on humans. It's some sort of gateway drug to who knows what. In the last century we found some molecules that alter our mind and mess around with it and now we can precisely modify its function and get the respond that we'd like to have. Also we get a better understanding of how our brain works, if we examine it from different sides. Thanks for the video!

[@williamdias3456]

The main reason for this is obviously to allow big pharma companies to create a patent to make money out of it . Cures with no possibility of creating a patent are always stopped .

[@deshaebeasley]

Five topics to fix society via discussion: -Anti-natalism vs Natalism -The 3 basic needs/prenatal needs Three things necessary for human evolution that are provided while in the womb which are; food, shelter and medical care. -Platinum rule Do whatever makes one happier unless it interferes with another persons ability to do the same. -MBTI (research yours and connect with others) -Art (pick one and get better at it!)

[@MandrakeFernflower]

I wonder if DFMDMA is being worked on by pharma?

[@ronalddesiderio7625]

Back in the day or in my small circle when I get clean X it was life changing. This is coming from a mental patient on psychiatric narcotics to function and be a productive member of society. I felt Good about everything and nothing was wrong or didn’t have an answer to make right. I miss that

[@renaudfensie3020]

sounds promising, hopefully it helps people who need these therapies finally get acces to it. reduced neuro and cardiotoxicity is a good added bonus too. i feel like they should have tested the 5ht receptor affinity of the n-demethylated metabolites since mda and it's analogs tend to be stronger agonists at 5ht2 receptors than their n-methylated counterparts

[@chemistrycapital]

@@renaudfensie3020 They suggested this as future work!

[@jaapmat]

Your analysis of MDMA pharmacodynamics is spot on! It's also worth noting that the R and S enantiomers differ in their pharmacodynamic affinities, with the S enantiomer being a stronger releasing agent and R being a stronger 5HT2A agonist. Additionally, some studies report neutoxicity in mice only with the S enantiomer, but not the R. This is definitely a bit too much detail for a video, and is mostly pre-clinical, so I tend to omit it from my own videos. But just wanted to throw it out there in case anyone was interested to know!

[@chemistrycapital]

Yes this is true! In this study they just looked at the racemate of each compound

[@The3rdPlateau]

I had no idea MDMA was racemic! That's utterly fascinating!

[@shad0ex]

@@The3rdPlateau Most Amphetamines are.

[@cosmophobia1917]

@@The3rdPlateau You are so dense, what are you even doing here???

[@ryan8430]

98-01 I took MDMA and went to underground raves in Detroit best time of my life

[@christopherleubner6633]

The diazole substitute for the methylenedioxy ring would very likely make extremely toxic compounds when metabolized.😮

[@toseltreps1101]

i don't get how this dude makes videos on the topic but doesn't understand basic toxicology

[@chemistrycapital]

@@toseltreps1101can you explain this further?

[@cajampa]

Why don't you explain it further if it is so obvious for you?

[@MrsMartyr707]

L ​@@chemistrycapital

[@toseltreps1101]

@@cajampa aromatic diamines are always toxic.

[@derenjoy3r]

Dope vid man keep it up very interesting to hear this

[@chemistrycapital]

Thank you, will do!

[@Henninchs]

OK - provocation on! All drugs that we enjoy have more or less predictable and incalculable side effects. Alcohol, as a widely used drug, is no exception but one of the worst drugs. How about researching recreational drugs for different settings that have fewer side effects. We are always researching how to tame the euphoric aspects, because we may have an ecstasy complex. I don't take alcohol and hardly any other drugs, but I don't think ecstasy is a bad thing, it can actually be great. In the end, people get high - danger or not - because it's fun. But if research were carried out to develop a drug that had nice desired effects while the side effects were comparatively low, many would scream reflexively while continuing to drink alcohol as if nothing had happened! It shouldn't be the goal to minimise the euphoric experiences but the side effects!

[@simoncleopater948]

To be very honest, I expect that the reduced efficacy at the 5-HT2 receptors even when paired with similar potency for DAT, SERT and NERT is going to lead to subjectively subpar effect. The main reason why some synthetic tryptamines with low/moderate affinity for DAT, SERT and NERT have strong stimulant/euphoric properties is due to their much stronger 5-HT2 agonism. This seems to create a balloon effect that much enhances the subjective experience of a moderate catecholamine increase.

[@HUSSEINHEFNER]

finally been waiting for mdma 2 for a while

[@WorkyGaming]

Why not benzotriazol core? More easily accessible via diazonation and cyclization of diamine

[@chemistrycapital]

@@WorkyGaming Could be interesting too! Would have an extra hydrogen bond donor which may impact its ability to cross the blood brain barrier

[@markk.8250]

what about Nichol's difluoro-MDMA, the fluorines act as bioisosteares for the methylenedioxy carbon discussed in your video. Nichols postulated a reduced neurotoxicity for this analog at least a decade ago. There is also the removal of one of the oxygens, "one-eyed jack molly" but I don't remember which oxygen can be removed without losing most of the efficacy. I am sceptical that an organometallic diazo is going to pass for MDMA, I sure hope so. If nothing else, it would be a stretch to consider a selenium compound an analog of something without selenium. I would take that case to trial. LOL. I do like the novel approach to constructing the mdp2p like structure... have to write that down...

[@Michael.Chapman]

Great to see another methylamphetamine analog of interest--sadly, the parent drug can probably never be rehabilitated now--though I wish its talented, diverse children well.

[@jeremiquirus1958]

Hey i would love if you could cover ligand binding assays in general and how scientists are able go measure binding affinities down to the hundredth or even thousandth Kd.

[@chemistrycapital]

Sure! I love working with the Biophysics team we have, there’s some super interesting techniques.

[@Jakob.Hamburg]

Sounds good. : ) If taken with care, MDMA has a huge potential for healing and allows important communication between anxious humans that are stuck in their mind. If there are less side effects when people take this new derivative, I appreciate it. On the other hand: Me and at least hundreds of thousands of other people globally took MDMA many hundred times and can handle it pretty well. Sure, I had some temporary mental downs, but I feel well, learned a lot by using it and had a lot of fun. My advice: If you consider it, Inform yourself about your possible individual risks and benefits before taking any potent psychoactive drug that is new to you. And also: In every country there are at least hundreds of psychoactive Drugs, that are legal and still historically tested/researched well, but the knowledge about them is publicly not widely spread. Enjoy life, be responsible, do good things.

[@MatthewJamesR]

where can i buy some

[@DagggGger]

this stuff doesnt work as good as back in the days

[@heinzletzte.6385]

I think something similar happened with 5-MAPB in 2020, it had way less side effects than MDMA and many people even preferred it to MDMA.

[@rdallas81]

Interesting

[@mitchelljacky1617]

It had waaaaay worse side effects. Especially when you'd dose more frequently or use higher starting doses.

[@heinzletzte.6385]

@@mitchelljacky1617 waht happened?

[@YokaiGotha]

​@@mitchelljacky1617you generally shouldnt re-dose or use frequently (twice in less than 6 weeks) drugs similar to MDMA or MDMA itself unless you want bad side effects.

[@equiles]

Side effects were much worse, at least worse than pure MDMA… but man thanks for bringing back some memories that stuff was beautiful. Wish it was still easy to get

[@TehGoldd]

Mdma cured my ptsd 3 years ago

[@nils9293]

Bro, the new update just dropped. I'm less sweaty now!!

[@Mike-dt1yg]

Everyone should experience MDMA and psilocybin at least once in their lives. They're truly enlightening drugs that at least for me have had major impacts on my life.

[@rdallas81]

You only think they did. Everything is the same. Thats the deception of drug use aka "Pharmeocea" as mentioned in the bible.

[@S0-102]

I have tried most of the stuff and have had amazing experiences . But there are many people who really should not try anything. Also It should come naturally and be pre-emptive.

[@pirobot668beta]

Psilocybin was a waking nightmare for me; that one experience was enough to make me swear off psychedelics entirely. I had sampled other things, but nothing prepared me for the horrors of psilocybin.

[@ricardorodriguesrr18]

​@pirobot668beta did you try low doses? At first I didn't like it but when I tried a very low dose it felt amazing I didn't trip but I felt more energetic and aware of my surroundings.

[@bixxybear]

The methlene-dioxy can be replaced with an indole and the amphetamine down arm removed and back of molecule tailed off longer. Now you have a medicine thats only mildly stimulant yet has a range of health benefits.

[@toseltreps1101]

The main concern with the Methylenedioxy bridge is demethylenation and oxidation to an o-quinone, which is quite toxic. Valvular fibrosis is a real risk with 5ht2b agonism, but as these agents aren't suitable for prolonged use anyways, there actual risk of cardiotoxicity is low.

[@chemistrycapital]

The ortho quinone is not a metabolite in the case of MDMA

[@SteveStevens-uv2px]

Yeah. Ain't no o-quinone, fool. Fo sho cuz. H8trz.

[@TrevLaurie-rx1jo]

Is there anything natural or legal that comes close to MDMA?

[@KuntChitface]

shrooms? idk

[@jackiepl7354]

Nothing legal

[@ekimako]

San Pedro cactus (natural)

[@cosmophobia1917]

5-mapb, 6-apb

[@crazysimec]

just imagine how these lab doctors making bunch of batches of pure drugs. I want to be there

[@aza1479]

Where to we find this analog to try

[@Boxmodzhq]

Iv mdma at 70 to 90mg the rush felt like electricity all thru my body n after a while when i could stand up my pupils were almost the size of my iris. But it something i wont repeat due to ill health but damn i still remember the intensity of the experience even today. N this was in 2007

[@ryanboje5693]

So how to these differ from 5 -iai and other rc analogues of mdma and mda? It’s this the same thing?

[@neilhidalgo1391]

Love it I wish I can get prescribed.

[@flyinfilm90]

Mdma has undesirable side effects ... finding transfer strategies around those would be fantastic

[@jopmens6960]

They should have assayed the demethylated metabolites (which would be analogues of MDA rather, regarding 5-HT2 receptor subtype affinity and efficacy. It seems to be more heavily implicated in this part of the effect.

[@chemistrycapital]

This was mentioned for future work :)

[@DebacleWhimsical]

I wonder how long before you could let an AI model could come up with the ideal solution given the current input and problems that exist.

[@quinsopher]

Hmm, would it still be patentable if it were AI generated or would it be opensource by definition?

[@user-RCST]

Do you think 3-CMC is neurotoxic?

[@cosmophobia1917]

it's not more or less neurotoxic than 3-mmc or 4-mmc

[@simhthmss]

I thought 6-aminopropylbenzofuran was found to be less neurotoxic?

[@maschinenorganismus]

Doesn’t MDMA block the ester group that disassembles serotonin?

[@Chemicator]

Great explanation👍 I liked the molecular docking section. It was very interesting. Why don't you use background music in your video?

[@chemistrycapital]

Thank you! And not sure to be honest. But probably because I don’t like it when I hear it in other KZbin videos 😂

[@Chemicator]

@@chemistrycapital I guess it's a good thing we’re balancing out the KZbin universe. I'll keep adding the beats while you keep it classic! 🎶😄

[@treelineresearch3387]

In all fairness there's no tar/yellow stuff synthesis montage to put some Aphex Twin type beats behind.

[@triple_gem_shining]

Music has no place in purely scientific videos

[@BladeGod7]

Thank you for not. I cant stand it, but its especially worse when they say nothing and don't even subtitle what they are doing. ​@chemistrycapital

[@NanoartsNet]

So what are these new analogs called?

[@travisxtopher]

Not approved so pharma companies can patent these instead. Hundreds of thousands of people have used MDMA, often many times and we just do not see neurotoxicity at scale.

[@gogo311]

Why not use the tried and true MAPB compounds?

[@equiles]

My friend is kind of dumb so he’s asking… is this chemistry actually developing a safer better MDMA or is it just a push for big pharma to get a patentable drug. Are there RC’s that safety profiles as good or better than this new drug?

[@chemistrycapital]

@@equiles The research was actually done by an academic group in Vienna in collaboration with other academic groups. The first author of the paper has even commented on this video!

[@cosmophobia1917]

5-mapb, 6-apb, they are all better, more potent than mdma, slightly less psychedelic, but not neurotoxic

[@eurohulk6515]

sulfur derivatives are often metabolised in microsomal assays by the oxidation of sulfur to sulfoxides and sulfones

[@chemistrycapital]

I agree! Although they did not pick these up in there met id. Studies

[@syno999]

6-apb deserves to be investigated, it really has some therapeutic properties. It helped me understand the source of bad behavior i had toward the world. It feels like a combination of a stimulant, an empathogen and a psychedelic. It helps with diving in old wounds and traumas without feeling terrified and facing questions or truths we use to keep under the carpet in everyday life.

[@happylarry274]

The sequel we never thought we would get

[@camfitt]

Anyone had a go at making this? Asking for a friend looking to conduct a research study

[@badacconosu]

Doesn't a large part of MDMA's neurotoxicity come from the excititoxicity? I really don't think any drug that aggressively revert neurotransmitter tranaporters could be used for lengthy treatment. Personally I've had mediocre experiences with the drug itself when I experimented with it. It's very dangerous to use synthetic feelings as therapy in my opinion, substances that promote functional connectivity reorganisation by affecting the DMN in a therapeutic setting make a lot more sense.

[@panekoekopjema]

Yo bro, I'm from the NL where designer drugs are kinda gray market. If they add fluoride to amphetamines (like mdma) it makes them more prone to vasoconstriction and brain bleeds.

[@chemistrycapital]

Is this a big problem in the Netherlands?

[@vankuihvlog5524]

@@chemistrycapital i guess vasoconstriction and brain bleeds are a big problem not only in the netherland.

[@TotalDec]

MDMA kept me going when I had nothing, and nobody.

[@alexandrerobert4100]

This is very cool. I never thought you could put hetero atoms like this. I think thio compounds may encounter greater metabolic capability in the body; hence their quicker clearance. Maybe because some thio compounds bear toxicity and mammal biochemistry evolved to handle it. The SeDMA is so elegant

[@iliddle96]

sulphur is probably oxidised

[@elqyanoesquia6877]

isnt mdma without 5ht2 activity just… ma? maybe its more biased to SERT but still id say especially 2a activity is fundamental for theraputic applications

[@TylerSmith-qx6uz]

I did mdma once every 60 days for 5 years with my gf, we have only had positive results from doing it this long. People are really paranoid about mdma.

[@kindbud]

Did it only decrease appetite while the chemical was in your system or even after as a side effect? sorry if i misinterpreted this ODMA looks like it could be a nice stable one with microdosing

[@OliverBodden-Howard]

wake up yall chemistry capital just posted

[@chemistrycapital]

You know you’ve made it when you get one of these comments

[@syrus3k]

Can't wait to give it a try!

[@StefanReich]

Very interesting. I just sampled 3,4-EtPV which is absolutely excellent. A full-on substitute for MDMA in my opinion.

[@OrganometallicPsychonaut]

MDMA makes me feel oh so good

[@bryanutility9609]

So which analogue gets you high without side effects?

[@SuperSamsungman]

H2o high on life

[@bryanutility9609]

@@SuperSamsungman not satisfying at all but I appreciate the effort 😂

[@vankuihvlog5524]

@@SuperSamsungman not even h2o, its stupidly toxic to vitamin b12

[@nicolasdewilde5838]

@@bryanutility9609 6-APB is close enough

[@blueberries254]

god that selenium analogue looks delicious

[@bofasaurus]

my problem with this new synthesis is the side effects that people are going going to experience through abuse if its less potent and "safer"

[@Neckelmania]

I think we're still waiting on data in human subjects. Who knows what the side effect profile will be.

[@Roman_Ray]

No matter what kind of mdma you take, you gonna lose something of sheer importance to you. A hexagonal qp-skull phill** *lein is sth different from a heart shaped pill.

[@skeetskeet4123]

​@@Roman_Ray Please may you reiterate, elaborate and apply a laymans approach to your last sentence bro?

[@morticialatex]

So the analogs regulations and laws have been overturned? Will a local sherrif even care?

[@grasshopper-ln9us]

First time is kinda scary but the 2nd and 3rd are the best experiences

[@Eatmorepaper]

The conjugation of the double bonds in the thumbnail is impossible, there should be 3 not 4

[@chemistrycapital]

Think about other ring systems such as indoles and benzofurans

[@foobarf8766]

This is fascinating! Can you do one on phytocannabinoids antiviral properties? How does that work?

[@ellamead2000]

This is really interesting!

[@chemistrycapital]

@@ellamead2000 thank you 👍

[@stevencamacho846]

2c1 2ce 2cb? Teehee Alex was at the forefront of this research! glad to see it isn't withering away in Pandora's box.

[@eltonmorris7228]

5mapb 6mapb is similar mdma Bk MDMA methylone also and very easy can made it without lab equipment very quik

[@KermitFrogg7718]

Removing the internal self navigational nature of 5ht2A destroys the point and purpose of internal navigation and empathy towards oneself & others with sudden introspection that won’t happen anymore, I predict it’s dopergenic response & amphetamine structure to be more focused towards adhd treatment & other dopamine deficiencies. Cubane remains a promising alternative tho as you have described with the receptor site mappings it’s about frequency modulation across protein folds like tuning an instrument as Tesla says crystals sing & you are brainwaves you are the frequencies and Tesla even describes how & why crystals sing and resonate.. recreate the “song” or frequency along the desired pathway. The chemical structure might not even resemble this stuff at all anymore..

[@jamiebury1807]

Improved safety damn mdma feels extremely safe at a normal recreational dose

[@neffix6976]

How about just using 6apb?

[@Kurt-o7w]

That's it I'm becoming a chemist

[@PosterJoe518]

I need some.....send it!!!