Embryology | Development of Skeletal System

[@NinjaNerdOfficial]

**Correction*** Hey Ninja Nerds!! The laryngeal cartilages are actually derived from the 4th and 6th pharyngeal arches NOT the 1st!!! Sorry about that ninja Nerds!!! Hope this video is helpful! Love you ninja Nerds!!!

[@nadiary5354]

Hey, sorry I think the part where you explained the process of differentiation of fingers got deleted or skipped? Thank you!

[@didiiyoho2086]

I was going to correct this. Good job

[@aneesmusic7174]

Tnx

[@Zahra-wj1qc]

hyoid bone actually derives from second as you said in pharyngeal apparatus video

[@lawrenceparkswimclublpsc2621]

nadiary jjjJackjjjjjijijijijjijjijijjijjijijijijijijijijijjijjijijjijijijjijijijijjijijijijijijijijijijjijijjijijijijijijijjijjijjijijjijijijjijijijijijjijjijijjijijijijijijijjijjijjjjjijjijijjijijijijjijjjjijijjjjijijijijjjijijjijjijijijjijijjijijijjijjijjijjijijijjijijijjijijijijijjijijijijijijjijijijijijijjijijijijijijijijjijijjijijijijijijijjjl

[@SydneyKay245]

I love it when Zach says things like, "isn't that cool?!" I swear having an excited, passionate teacher makes SUCH a difference. Thanks, Zach!

[@adrianawesomeful]

2:55 he even says "neural crest cells" as if he just met the love of his life for the first time AHHAHA great lecturer!!

[@n3me51s2]

Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?

[@johnstillman2935]

I'm so sick of hearing him say isn't that cool

[@kroaky6892]

Development of limbs 1.HOX, TBX4 & TBX5 genes determine the position of formation of limb buds. Once activated, they stimulate release of FGF-10 (fibroblast growth factor). Ectoderm grows off as 4 limb buds. Somatic layer of lateral plate mesoderm moves into limb buds. FBG-10 stimulates a thickening at the tip of the limb buds called apical ectodermal ridge (AER). AER secretes FGF-4 & FGF-8 which causes proliferation of somatic mesoderm. the most distal part keeps proliferating (progress zone) while the proximal part of limb bud starts to differentiate. From cartilage to bone (endochonrdal). Some tissue in AER undergoes apoptosis due to bone morphogenic protein (BMP) & retinoic acid increase. Starts to form fingers. Mesoderm starts to proliferate to make finger bones. AER dies off to stop growth. Tissue called zone of polarizing activity (ZPA) develops on posterior disal limb which causes the asymmetrical growth of the hand. Thumb to pinky.

[@alijenedi9500]

sincerely, thank you for this. you have made my exam period at least an hour or two shorter.

[@areeba2729]

A Pakistani med student here, trying to study embryology from scratch 2 days prior to the exam. Thank you for your energy and explanation!

[@tejassahu8755]

Same here , used to overestimate it, but it’s such an exciting subject, kudos to Zach sir

[@AyomideOtesile-fk8df]

Hi Zach. I am Alice, a Nursing Student from Nigeria. I love your energy and enthusiasm while teaching. You also made this topic easier for me. Thank you.

[@alih6953]

Zach you are my mentor and hero. You don't even take Sundays Off! Thank you so much. God Bless you and everyone

[@NinjaNerdOfficial]

We are always in your corner! No days off! 🤓

[@n3me51s2]

Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?

[@TheMoonlight258]

Hello Zack, I’m a medical student from Iraq, and I just want to thank you for all the work and time you’ve given for everyone who watches your videos. You explain in a such way that is comprehensive yet still fun and enjoyable. Keep going man, wish you the best of luck!

[@sportiac6564]

Which book do he follow?

[@1Itsyasr]

يييي بالقرآن

[@Shinzo9567]

يامرحله ضلعي ويا كليه

[@TheMoonlight258]

@@Shinzo9567 طب تكريت مرحلة ثانية و انت؟

[@Shinzo9567]

@@TheMoonlight258 اني هم مرحله ثانبة مستنصريه

[@samwarren2850]

when my med school prof lectures about this subject she just throws it all up on one powerpoint slides and talks through the whole thing at once, which i find very hard to follow and understand. drawing it out step by step like this is immensely helpful, thanks!

[@carloferronato2308]

i'm an Italian med student and I actually prefer this to may Professors. Thank you for everything you make Zack and crew

[@bilalmuslim4002]

I am an Iraqi med student. Definitely, it’s better than what the professors give. It’s well organized and simply explained and understandable

[@davidkuledjawa8447]

Am a proud Ninjanerdian 🎉. Thanks buddy 👍

[@japaniphal872]

A Pakistani Med student here, learning a lot from your videos. Keep up the good work

[@melodytoth7476]

Hungarian med student here: My anatomy professor is an absolute mess and speaks super fast at that too. I've only had a couple of lessons with him so far, but I'm so incredibly lost. I voice recorded the lesson for myself, so MAYBE I'd understand a word from it, but no... nothing. But this video... Thank you! From the bottom of my heart, THANK YOU! This was so useful and exhaustive and understandable and finally I have an idea about what is going on. Truly a blessing to have you share all this on this platform for absolutely free. I gotta share this video with the others, as well as look into your other stuff, because you are genuinely saving me with this.❤🙏

[@nadiary5354]

I can't stress enough how you actually saved my medschool life 😭

[@okehinde175]

Thanks prof….I’ve been following your playlist...prepping and priming my brain for second year of med school here in Nigeria as things can get really overwhelming . You’re an amazing teacher..

[@adrianaglavan2208]

I just wanted to say a most sincere THANK YOU! I really appreciate your work and you must know how much it helps everyone who wants to learn. Thank you again ♡

[@selenaserane2623]

Zach is a treasure that must be preserved!

[@muhammadsohaib6282]

Hi ZACH . I am an Electrical Engineering Student But I'm here to Subscribe you channel because My Brother loves Your Lectures. Keep up the great work! LOVE From PAKISTAN..............

[@musicupmylife6116]

Those with ADHD but still fighting, i feel u and im proud of u guys we can be even better …

[@陳曦-p3j]

Thank you!

[@thechristianspath2589]

Zach’s a lifesaver. Love from Nigeria ❤

[@rebecalombrana7689]

Never have I ever wanted to hit the like button so many times. Thank you so much!

[@musfirahkhan7553]

In love with his way of teaching 😭❤

[@zirwasiddique7658]

I swear I have NEVER even considered signing up for Patreon for any other channel except this one. I hope I will in the future.

[@weyessateresa9502]

I am very grateful for the support you are giving us ninja nerds you are the most influential man in my medicine career

[@akarim_fye6842]

Lots of love from Medical School of the University of The Gambia🇬🇲🇬🇲🇬🇲🇬🇲🇬🇲🇬🇲Thank you so much for your videos.. you're just Amazing!

[@randomcontent987]

Hi, from Pakistan... Watching 2 days before Professional exam

[@Coco_cocainestudy]

🫡

[@ameee7902]

Thank you so much for providing all these lectures!!! 💕 looking forward to more embryology lectures from you!

[@n3me51s2]

Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?

[@WhereAml]

Finally, embrio vids, really needed these to jog the memory

[@MD-2101]

Embryology😻 The greatest gift ever for my upcoming semester. Thank You Mr👍🏻👍🏻👍🏻👍🏻

[@lottahansen6601]

I always hated embryology!! until I found your videos :)) it can be sooo interesting! THANK YOU 😀

[@alih6953]

Holy smokes! 1000 Likes and 0 dislike! Zach you are amazing!

[@clarencechauke3419]

brilliant teaching from you Zach...you're a blessing to us!

[@n3me51s2]

Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?

[@franciscozapata9332]

Thanks ninja nerd, i am a second year medical studen from venezuela, your videos are super easy to understand and it have being keeping me motivated trhough quarantine. I am even thinking about opening my own youtube channel now. thanks

[@n3me51s2]

Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?

[@chaampyanking8278]

He is the best believe me.Anyone who is reading comments to see whether he is good just follow his lectures.Explaining embryology is really difficult but still he is from another planet.

[@Maryam-kj5li]

Brilliant as usual. But what i really want to thank you for is your positive energy. I woke up not in the mood for learning anything about embryology 😂. But the way you explain and the way you seemed so excited is so refreshing! And contagious. So again, thankyouu for making our lives easier

[@n3me51s2]

Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?

[@alih6953]

Dear Zach Thank you for this! Explanation for the 44:40 is missing about Retinoic Acid and SHH about how Gremlin-1 is released

[@m.hashiryazdan8066]

Now this guy is just exceptional

[@aleksakopcic3170]

Thank you, thank you, thank you! Keep it up with embriology!

[@n3me51s2]

Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?

[@LINASHEKADZIRANGE-ge4jz]

Thank you prof Zach..You jus the best ...You make our med school life easy

[@SentientBurrito]

from ninja to nerd and where I'm at? I'm dead in the water mate, and it ain't a pretty sight! But thank you for all the work you've done and are still doing.

[@saadraza6311]

Your videos are as good as it can get.thankyou so much and please keep them free on youtube

[@AminaAli-jv5xr]

Watching your videos from somalia 🇸🇴 and thank you for sharing these wonderful videos with us (med students)

[@Clear4ce]

This video published less than 48 hours before embryology exam. Nothing less of amazing. Thank you guys!

[@n3me51s2]

Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?

[@thebeets6055]

I'm not even learning this yet but I just wanted to comment to voice my support for this channel. Just incredible

[@paulina4925]

Having histo+ embryo in two days and this just came perfectly in time!! THanks!

[@jasonho1694]

youre the best thanking you for helping me through medical school

[@Эльвира-ю4з9г]

I'm in love with this channel, thank you so much

[@echobellem1610]

Nerdology : Development of Ninja Nerds

[@Cherryjapheth]

😂😂

[@Mohamed-jv6nv]

That would be the study of ninja nerds. The development would be called Nerdogenesis. 😉

[@pearlase8389]

You are one of the best things KZbin gave me😇😇😇😇💙💙

[@bethelihemtakele3211]

I can see how much effort you made when I see your videos

[@haranhimmelman9598]

Your passion really gives it more color and makes it interesting.. very inspiring thank you

[@blackpaw357]

During the first half of the video I was trying to figure out what kind of drug Zach is on. Then I realised it's just embryology. Because damn, embryology is so so cool!!

[@Ohhhkkkk]

Wow! Excellent explanation! Thank you so so much for putting the time and the effort to make these topics very enjoyable to learn.

[@musfirahkhan7553]

I had to stop this video and appreciate this guy 👏

[@jav4346]

You have no idea how easy you’ve made me revision process for exams

[@anotidadziva8759]

Thank you Zach so understandable and simplified

[@priyanka036]

Lucky to have you as my teacher thanks sir for all the beautiful informative videos

[@alih6953]

# Ninja Nerd for life. Once you go Ninja Nerd, You don't go back

[@JGscienceGaming]

I just got my psychotic preworkout in the mail! Omg!!! I feel the electrons coming out of my membranous neurocranium!!! Thank you Zach!!!! Biochemistry major let’s do this then MCAT!!

[@MD2BE]

great video~ currently an MD1 and this has helped alot!

[@maherdeli]

Thank you man Really appreciate it Med student from Iraq

[@RTAJ086]

This topic is very amazing, as many details indicate the existence of a creator for man, and many thanks to you, amazing doctor, for your full discussion of the topic, you are the best doctor 🤍

[@riekookabayashi8510]

The way you talk to the audience looks so enjoyable that really attracts us by your lectures. Love your spirit ❤️ Keep it up 👍

[@lavdieel2369]

I've been waiting for a long time for this! Thanks a lot!

[@mduplooy6763]

You are SIMPLY THE BEST ZACH!!! thank you thank you for all your hard work and dedication!

[@markonemet3400]

One interesting (important) fact: The nucleus pulposus is the only remnant of the notochord, not sclerotome! Sclerotome gives rise to vertebral bodies, annulus fibrosus of the intervertebral discs and ribs!

[@brunettesupermacy6745]

Man you are literally my career saviour ❤️

[@nasraabdi5467]

Its 3:00 am, i have an end of sem 1 exam and things just escalated quickly from neuroanatomy to embryology to bchem...am glad this made my work 1000 times easier

[@OZK2771]

Best instructor ever 🫀

[@drfatimaghafoor]

Again excellent explanation of this system. well done!

[@annalee3708]

thank u soo much for this video, it's helping me to understand more during my uni class

[@currentlyprocrastinating-ix1zs]

bro has rocked my world

[@中山醫學大學雅頌-b7d]

Thank you so much for the embryology lecture!!! Just want to make sure that does hyoid bone and laryngeal cartilage comes from 2nd~6th pharyngeal arch. thanks a lot

[@lolakhalid0504]

Zack i am so thanking you at my graduation speech !!

[@محمدأنور-ه4ب]

Thank you very much 💚. We are waiting for the embryonic formation of the cardiovascular system

[@medicalstudent8439]

Wow ...thank you ...your all videos are interesting...you make me love 😘 the medicine...

[@GhadeerAL-Ammari]

Greatest teacher ever ❤

[@stevemas4966]

Zach, After watching many Ninja Nerd Lectures on KZbin, I've become very impressed with your knowledge. Are you accepting patient? If so, how would someone become a patient of yours?

[@e.a.c8309]

Hi there. First of all, I love all your videos. Please do make a short video on the development of the joints. Thank you

[@noorezo1492]

You make the madicine so easy 🔥🔥🔥love you

[@michagorzynski9436]

Ayyyyy, let's go! Missed embryo lectures

[@fatimamudhafar]

Thanks a lot from Iraq for providing these videos, keep going!!

[@nehalemad7740]

I just wanna say thank you very much and keep going in making wonderful videos

[@rachelhoksbergen711]

It is amazing how you are able to make these wonderful educational lectures! I am Rachel from NL and I really love them!

[@godwindabere1677]

Thank you very much zach. This is really top notch

[@daninduks6349]

Thanks you sir. Really helpful.. forever a proud ninjanerd

[@rocwithme7898]

this guy hits it everytime! thank you brother

[@salaheddinehouache1015]

Thanks for your efforts Ninja crew

[@SCP--xk1up]

Love this. Ur passion really gives me the motivation to learn!

[@dewakhandewakhan2170]

Really sir i have no words to explain how you are helping us by your great lectures......amazing sir

[@evridikisiara9803]

omg! finally it all comes together making sense! I am so thankfull for your job and for the fact i had the luck finding you

[@mohammedmahbooba4079]

The greatest ever Dude without you my medical journey is sh*ty♥️

[@MsStrawberry196]

Nice to see, how much fun you have with this stuff

[@justicebogban8478]

Awesome lecture. This man is Good

[@victoriagoetz9002]

Thank you Ninja Nerd.

[@TachyTutorials]

Thank you for breaking down such difficult topics!!!

[@kosargn8124]

Hello guys !!!! Omgggg thanks for amazing videos really !!! I swear when ever Zach says " oh man it's so cool " or " isn't that cool ?" I keep rewatching that part 😍😍😍and I swear I learn a lot better he knows how to drag good attention to super important parts !!! And yet keep it so intresting ! Like only by his joy in his face he converts all boaring materials into such a cool one to learn ! Thank you guys ! May God always bless you and get your backs !!! I love youuuuu guys

[@n3me51s2]

Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?

[@phubusa2022]

The lecture is so nice, understandable and interesting,,add more for us!!!!

[@noumanullah4311]

The way you expresses the things in lecture Help me get rid of depression 😂

[@PAULIAM95]

Those Somites dividing gave butterflies in my stomach

[@kosamchitalu1838]

HEYY NINJA NERD IT'S KOSAM FROM ZAMBIA, WE LOVE YOU IN AFRICA.