Endocrinology | Adrenal Gland: Cortisol

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Ninja Nerds!
As we continue through our 4 part lecture series on the adrenal gland, Professor Zach Murphy will be teaching you about the zona fasciculata and the main hormone it secretes, cortisol. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #Cortisol #AdrenalGland

[@AY-ct8yj]

I like the colors matching between his T-shirt and the zona fasiculata

[@AY-ct8yj]

@@qlee9529 Hahaha, he didn't, did he?

[@utsavimishra106]

I was literally going to write this comment too..

[@unknownhelper7475]

Ohh yes same😜

[@mannmstorm]

På p

[@IslamK1959]

You are a fool

[@anuragekka317]

The whole world will benefit from you and your hardwork. (Mostly patients and all health care professionals watching definitely). You make medicine so interesting its like watching Netflix Thank you. Love from Odisha, India. 🇮🇳👳🔥❤

[@rickm9925]

You're the best there's on youtube in my opinion. You really know how to start and end smoothly, explaining every detail in order to make sense out of things, not just memorizing and goodbye. THANK YOU VERY MUCH, YOU'RE A REAL HERO! WISH YOU ALL THE BEST IN EVERYTHING! YOU HAVE MANY SUPPORTERS! KEEP IT UP!!

[@juliewiener9945]

Oii

[@johndoh1000]

Omg I love these videos! When you paused to while you were writing gluconeogenesis for the first time I yelled it out like a five year old girl watching Dora the explora

[@kushagarjuneja9996]

You are unbelievable, top-class lectures. Wish you all the best and happy 2019.

[@DrSN_02]

And now we watch this masterpiece in 2024

[@utsavimishra106]

It was such blessing to find your channel... Thanks a lot sir!!

[@TusharPhogat]

What would I do without you! Cannot thank you enough🥺❤️

[@malaikamuskan9971]

I love your scissors enzymes 😂😂❤️

[@KirbytheRagdollCat]

Grade saver. Professor covers an entire chapter in 20-40 minutes. You take that time for one topic out of an entire chapter. Thank you. Really grateful.

[@MadinaYtshorts-h3v]

So nice way of teaching 🌺 you really make a movie that fits 💯 in brain 🧠 you really deserve millions views ❤️ thank God I've Found you luckily ❤️

[@kritartha3293]

Sir you're the best, making concept s Crystal clear for us...love from India🇮🇳

[@Gurudrawing123]

This type lecture will increases competition in future😁

[@comicsbysaif3017]

Why does adrenal gland look like he's the impostor from among us? 😂

[@suzannestone798]

wow, you are alot smarter than you look. lol just kidding. I was diagonsed with Adrenal insfufficiency 10 yrs ago, this is the first time I have ever really understood it

[@ahadalhashem521]

you guys are the best

[@NinjaNerdOfficial]

Thank you so much Ahad!

[@lamab8410]

you're the bestest

[@shuvoislam8104]

Just one word i wanna use...u r a genius and u have god gifted teaching capacity my dear frnd.....hats off to u

[@chotavim1459]

You're the best I wish to have a teacher like you....and I'm trying to stimulate the growth of your channel by sharing your videos with my friends

[@princebassi8604]

Man ur are God of cortisol👑

[@dedefox2172]

Cortisol is dicey 😬🤝 a good bitch and a bad bitch ...🤝😭

[@rishabhsharma-fg7dh]

You have an amazing and effective way presentation. 👍 . Learning can be fun with your lectures. Thanx for explaining in such a good manner.

[@philipmaxwell669]

As a nursing student although the detail is intense I find that it can only be beneficial to understand the processes at this level, Thankyou for such an engaging and thoroughly researched video

[@barbaradonohue4822]

Agree. I use his videos for Bio-Psych because the details makes it so much more tangible.

[@j.sbhandari8813]

As u always I don't have enough words to say u thank-you, u are amazing, thanks for each and every video, God bless ❤

[@siddhanthravichandran3245]

Just wondering.... Is the immunosuppressive action of cortisol useful in some way ? , physiologically speaking. Why would we want our immune system to be suppressed during a time of stress??

[@Skytall]

Fantastic. Thank You.

[@NinjaNerdOfficial]

You’re welcome!

[@Cmyildiz]

today I realized our teacher watches you guys :D By The Way, I love your work and I hope it becomes get bigger and bigger. Keep it up

[@symoi1569]

for the first in my life, I'm enjoying studying this much, thank you so much for your efforts (and team).

[@onah]

I have an endocrinology test tomorrow, you have saved my ass bro!

[@akashpatil6247]

Sir....plz make video on peritoneum anatomy ....we are feeling it difficulty 🤗

[@leonardOoAugusto]

I had no idea of the indirect regulation of cortisol on glycogenolysis. I swore the stimulus was direct. Excellent explanation. I'm a big fan of your work, I want to be a professor here in Brazil (I'm a medical student). Hugs and thanks!

[@zekeriasvarg530]

I think that glucagon is the one rising when sugar goes down,, and that glucagon drives the pathway ( low citrate levels) of glucolysis.

[@hawiii1543]

I really love your lectures bro! you are genius !

[@dzastro8908]

I have a question sir, if the body is facing a Hypoglycemia, why would there be a Glycogenesis( stimulated directly by Cortislo as you shown)? And thank you for all your efforts sir, you are amazing!

[@tineeazyabuvall151]

You really cures the whole world this video bruh. To bad people don’t want to be a doctor to themselves. Absolutely a standing ovation 👏🏿👏🏿👏🏿👏🏿

[@misbahhussain1021]

Sir is angiotensin ii having only role inthe synthesis of Aldosterone ..?

[@josetrujillo738]

1 million subscribers! Wow! This is awesome! Also, these videos are so perfect! Thank you Zach, Kristen, Rob!

[@OrsiN-r1e]

Wow ! Your explanations and diagrams are fantastic ! Please don't ever stop doing these!

[@errrccc]

I'd always been confused about the specific functions of cortisol. This is such an amazing explanation! I wish I had found this channel when I was in college. But as a health care professional already, I'm still so thankful for these fun lectures!

[@annaatrasfitness]

Fanstastic breakdown of the topic.

[@gigidebas7117]

You are the best, swear to God, you and Dr. Najeeb have saved us medical students so much time, I especially apperciate your videos on heart failure, it was too much and i hated it but now i have watched all your videos on it, and finally have a good understanding.. thank you so muchhhh, I am watching you from Ethiopia..

[@DarleneDeSilva]

Absolutely blown away. You are so knowledgeable about the human body. Trying to educate myself because I have high renin and high aldosterone levels and low potassium. The doctors are stumped on this one. I think it might have something to do with not being able to reabsorb water. Maybe the proximal convoluted tubules. Still having tests done.

[@womenadrift3811]

If you doing a ketogenic diet: glucose goes down and ketones go up. Would the reduction of glucose cause an increase in cortisol? And once entirely keto adapted would this then decrease because ketones would be a good energy source? Since low carb diet is shown repeatedly to reduce metabolic syndrome i.e. BP, type 2 diabetes and other elements, I was wondering if this would be an explanation? Great teaching!

[@journeywithcharm5174]

Why it is converting glucose into glycogen in liver in first place if indirect stimulation of liver by cortisol would anyways again convert glycogen to glucose??

[@bebomilad3593]

thanks a lot sir ..... i'm from egypt

[@mackenweck1390]

Great video! What is the point of stimulating glycogenesis first and then indirectly glycogenolysis, and how does it ultimately increase glycemia and not just cancel out? Cheers :)

[@augustfinn5704]

Ratios unbalanced most probably (how much and how fast is the catabolism process)

[@maffigaron4993]

I love your team! Thank you so much! God bless you!

[@malaikamuskan9971]

U r amazing nobody is here like you ❤️🙏🇵🇰🇵🇰

[@somyali4060]

can u upload something with context to thymus, kidney n heart hormones.

[@spatiality]

I am trying to find something more mainstream. This is a little wordy but I appreciate the attention to detail

[@meghnahaloi358]

SIR, Your videos are very helpful. You are the best teacher, guide . I am a med school student from INDIA. None can teach like you do. THANK YOU SO MUCH . WISH YOU ALL THE BEST IN EVERY ASPECT OF YOUR LIFE.

[@yogayantra]

thank you sooooo much, really. I am a fast-lover, and i am at the top of my shape every time i fast. I am always sorry when I hear people confusing fasting and starvation. Fasting does not reduce the muscles. i have fasted only up to 10 days, and when i got back to the gym, I got back to the same weights, to the same number of reps...

[@ohidesamsonachaha2552]

i request if you can do the tutorials on defficiencies of adrenal cortex and medulla .....i love your work by simplifying the content

[@dres4801c]

I. Love. You. - from a current MS1 who's taking out wayyyyy too many loans to basically learn more from this amazing channel than from some of his med school lectures

[@someone.F.e]

Can you please take a pic for the board at the end of the video and put it on Instagram ore just at the end of the video? Pleaaaaaaase

[@JessiSabriT]

you're such a homie and you're helping me be a future kick ass nurse. Your work benefits patients. Your impact is huge!!

[@eleesetiminey5234]

My 4 year old niece loves watching your videos with me! She loves your bright shirt here :)

[@hammadkhan5973]

studying for a presentation...thank you. the pathway's explanation is elite

[@naylar.aprilla4416]

I'm a high school student and I understand this! thank u very much

[@Vlog_Planet360]

Bs kro

[@emirhankose8222]

Çok fayda sağlıyosunuz ; teşekkürler 😊

[@ara7048]

Can you please make a video on steroidogenesis (making glucocorticoids (aldosterone), mineralocorticoids (cortisol) & androgens (estradiol & testosterone) pathways from cholesterol)????

[@djtonitontonnewzealand3193]

My oncologist said my pituaritary gland is non existent - no cortisol, diabetic insipidus, dam breast cancer , Im in big trouble, you answered alot of my questions, can u do pituaritary gland system, i have breast cancer , lypmh nodes were all cancerous. Stage 4 reoccurring cancer. I get cortisol injections and drinks. It works. Vitamin D and Potassium deficient. Question , whats diabetic inspidus? he said 8 other problems but i just got stuck on non existant

[@cheydinal5401]

So what effect does super-high brain activity have on glucose levels and thereby stress? My guess is that if your mind is racing - whether from trauma or from being in a fight/argument, or stage fright, or whatever it is - that uses up a lot of blood glucose. After all, the brain uses up about 20-25% of the body's glucose of the body's resting metabolism, so a big jump in the brain's activity level can really increase glucose consumption Especially because when we use a lot of glucose in our muscles, the body has other ways (without cortisol) to produce more energy, via "burning fat". But when the brain uses a lot of glucose, it seems that the body's only way to increase bood glucose levels is to increase cortisol It could be that low glucose levels *is* (or at least can be) the effect of subjectively stressful situations, that make the person's mind run wild and massively increase its activity level. Also: If cortisol is produced in the brain, and the blood flow to the brain vasoconstricts disproportionately much during cortisol (as part of the fight-or-flight response), couldn't that be the reason, why sometimes very stressful situation self-perpetuate, where the person is stressed (cortisol) and then because they're stressed they keep being stressed (cortisol). Of course, generally low glucose levels, as well as permanently more vasoconstricted blood vessels (it seems that permanent super-high "stress" leads to that) will make some people a lot more prone to stress, *especially* with a self-perpetuating mechanism such as that

[@aydaabdolmanafi]

I have a SUGGESTION!🔅 Please put the picture of the whole whiteboard at the end of your videos so that we can take a screenshot and have your brief review all the time❤

[@salma-hd5gc]

This is so incredible I mean I can’t describe how amazing this video Thanks alooooooooooot❤️❤️❤️❤️❤️❤️❤️

[@fil.ip1]

Really great content I like it so much to listen to you. But one Question. Through my exams I wasn’t sick. The sickness comes first after the exams, so the influence of the cortisol isn’t that high compared with the other impacts while we stressed.

[@fleytube]

I am not sure if ACTH specifically stimulates adrenal fasculata layer producing cortisol or includes whole adrenal cortex’s hormone since the Cushing disease may arise from pituitary gland tumor or adrenal gland tumor. As a result, we only be taught measure cortisol level

[@y.5107]

Awesome video but didn't get the point why the body would want to create glycogen from glucose while also using glycogen to create glucose. My first thought immediately is why not do nothing and keep the glucose in the first place.

[@anhtram2740]

I wonder the process of increasing glucouse in the liver. There is also the pathway decreasing glucose by breaking glucose into glycogen( glycolysis) . So the cortisol can also reduce blood sugar ??? I still consider about that!

[@cheydinal5401]

This explains why some people have a habit of eating sweets (or say ice cream) when they're stressed (high cortisol): Because they on some level know that it will make them less stressed (lower cortisol production) - at least until the insulin has kicked in for a while and drained the blood flow from the glucos, bringing it into that fat and muscle cells, and thus the cycle sort of continues, possibly at least

[@evergreen1326]

Can sb explain what is the correlation between lower inflamation and increased gluconeogenesis? Like why did it evolve to do both things which seem separate? So that cortisol to be the only one that produces damage? (Cuz it lyses a lot) this seems not so productive for me as inflamation doesn't occur unless there is a pathogen, i mean the damage dealt by free radicals etc outside an infection is non existent Or this is what i thought. Can sb help me pleaaase

[@andrewtateismybestie2291]

So you're saying am getting sick coz of cortisol 😔 damn sh*t this exam will kill me frl

[@ReemAlzaidy]

In one word ,,, amazing

[@dannyc3340]

I am at the airport, I feel like I am in a university class surrounded by graduate students. I never had the prerequisites nor did I do the assign reading.

[@kenyalove5705]

i hope he goes to heaven. HEAVEN. THE HIGHEST RANKING IN HEAVEN. HIGHEST ONE.

[@PepsiT98]

Not only did you make this make sense... but you made me ENGAGED and interested in it... definition of a good teacher

[@PepsiT98]

Like when you explained the cause of sickness during finals is bc of cortisol's effect of immunosuppression... MIND BLOWN

[@umakantshinde2849]

Awesome sir......u explain all things with detail without any doubts...😍😍😍😍

[@dovenicolevlogs]

This is by far one of the best videos on cortisol I've found

[@mariamexia5698]

you're incredible! im a medicine student and im so glad i've found your channel! grat job!

[@nuutkaheeyit1048]

😢me too

[@iuw3ug]

Loving your lectures. Sending a million thanks. ❤

[@monojitadhikary3453]

I do have a question though if cortisol is released in response to stress why does it decreases our immune system shouldn't our body need immunity at times of stress how did in the process of evolution when we ended up reducing immunity when faced with stress

[@b.s.1302]

you are even wearing a green t shirt to better help us / remind us that you are talking about the green layer of the adrenal cortex, thank you haha !

[@annucoco6830]

You have given me more information then my doctor For 6 years i have just been given test and no explanation or resolved of the test

[@monalibhiogade5213]

Very nice video sir.its very helpful.

[@kush3247]

You deserve much more subscribers than right now you have.

[@cherylrangel5613]

Great videos. So if cortisol and acth arent appearing to regulate each other what could be going on? Could low adrenal function cause low blood pressure?

[@zekeriasvarg530]

Cant just speak about cortisol without glukagon and insuline . Actually this is really complicated in detail. Ask the professor how the interactions look in detail. Its one million enzymes interacting and you cant see those under a microscope.. thats why biochemistry in one way suchs.. they never have to derive anyting as in maths.

[@wallflovr]

Cortisol Affect Protiens, fats, norepinephrine receptors. Target organs-muscles, adipose, liver, blood vessels, lymphocytes Stimulus-stress, hypoglycemia, inflammation

[@stefanweilhartner4415]

this is why vitamin B5 and B6 are so important. B5 increases fatty acids burning in the krebs cycle with more AcetylCoA. That results in less glucose burning and the blood glucose level does not drop that much. so cortisol is not increasing ==> less catabolism. also less pregnenalone steal ==> more DHEA/testosterone. similar for B6, it is used to make more serotonin and melatonin/gaba. ==> better sleep ==> less cortisol. less cortisol, less protein catabolism ==> lower blood sugar ==> more glucagon, more hormone sensitive lipase ==> more body fat liberation ==> more glycerol to make blood glucose, no protein catabolism needed == less pregnenalone steal, more DHEA/testosterone. b vitamins are great! mega dosing b5 and high dose of b6 is fantastic. i use 5-6x500mg B5 and 4x17mg B6

[@madisonriley1725]

You are literally saving me thank you!

[@zelenplav1701]

Having high cortisol levels for decades, what happens?

[@AbrarSaif-kj5py]

The way you explained why we become sick before finals....it's mind blowing...amazing explanation by an amazing teacher....you're a gem sir....Hats off

[@cheydinal5401]

Also: So based on some stuff I've read and such, plus personal experience, I've noticed that I have a lot more energy, when I stop take 10-15 grams of proteins (protein powder/shake) every 4 hours, in combination to eating some 50 grams of carbs every 4 hours as well. That seems to be because certain amino acids are needed, probably in relatively large quantities I assume, to build enzymes that help digest carbs in the gut. That, as well as stuff like Omega 3, which according to some studies literally lowers blood cortisol levels, really helps me not be stressed. The cortisol-reducing effect of Omega 3 probably comes from the unsaturated fatty acids, that is Omega 3, also needing CBG/Transcortin and Albumin; so it leads to cortisol not being able to even get *into* the blood, because it's hydrophobic

[@aidaniknam2774]

Thank you so much for making these amazing videos. You not only make the concepts easy to understand but you make them so much interesting so that i wanna learn more.

[@sumitgami6349]

🔥🔥🔥

[@ahmetumutorhan8574]

Zach abim çok delikanlı bi adamsın abim erzincandan sevgiler.

[@corinnefurnari9150]

Thank you for your clear and detailed explanations.

[@immortaljellyfish0000]

I am currently being tested for Cushing's Syndrome which has been a total mind bender. Due to a radical hysterectomy procedure & a long period of extreme stressful conditions, my body does not produce the hormones necessary to offset the effects of hypocortisol. The effects are miserable...to say the least...My question is: Are the fatty acid deposits responsible for the "buffalo hump" seen in many Cushing's patients. If not what causes it?

[@knasta4099]

Thank youuu-Daniella from Tise’s phone😢

[@matheuskeocheguerian8734]

How much time to cortisol make catabolism protein in the muscles? Because in a fasting time the HGH levels enhances and he acts like a sparing protein, blocking the muscle breakdown. A study of 1 weak of fasting in humans have increased GH levels 1250%. So, how much time to the catabolism protein occurs because of the cortisol? Thanks!

[@Mthld-ym8my]

professor ZACH MURPHY came in CLUTCH. he is my lord, my saviour, my everything.

[@houuuda56]

though we've took this lesson in french but u're simplfiying it a lot , thank u so much guys u've killed it . keep it up

[@ujefmakwana5070]

Oh my god !!!! very very instresting video.. how 20 minute spend I doesn't know!!! 🤩🤩🤩🤩🤩

[@aryanbatra1547]

Am i the one? Who noticed the zona fasiculata and t-shirt?😆🤓