Oxygen Is Killing You | Answers With Joe

[@brianmandeville1117]

"why do we stare in the fire?" My dad always called fire "caveman television" on camping trips. Funny to hear that there is some truth to that statement.

[@mohamadhoseinf1560]

your father is a wise man

[@henrythegreatamerican8136]

We stare at fire because we are subliminally thinking of all the potential destruction it can cause to our enemies if "our tribe" just learned better ways to abuse it!

[@Phlyinhigh]

@@henrythegreatamerican8136 Yeah no thats a very cynical view point not all humans are violent

[@restaurantelajoya6929]

We didn't start the fire.

[@jacobburns1095]

@@Phlyinhigh I don't agree with Henry, I think we like fire for a multitude of reasons. But humans are violent. Violence was necessary for our survival. In modern times it's mostly subconscious, most don't realize they have that side to them. Until they are put in a situation where it's needed, or comes out anyway. The fight or flight response, every human has both of these behavior hardwired into them. No matter how how nice and gentle someone is, they still have the potential to be violent. We are animals, trap an animal and it will fight to defend itself. Humans are also predators, without the capability of violence we wouldn't have made it this far. The hunt for prey using our smart brains and groups of people is literally what made humanity who we are today. We aren't a new species either. We are the same humans as those hunter-gatherers who lived thousands of years ago.

[@0130wallace]

One of the first 'Philosoraptor' memes was: "What if oxygen is actually toxic and just takes 80-100 years to kill you?" Philosoraptor is wise.

[@suicideistheanswer369]

ah, good ol' days, except for the rage comics. i'm glad that one ended.

[@xironevarus576]

I was high when the thought came up. So wise may not be the word

[@LoneStarr1979]

Point is: Oxigen is actually toxic. When breathing pure oxigen under a [edit: slightly] high pressure (59 m and deeper [edit: actually 3..4 m]) the oxigen toxicates you because the anti-oxidising mechanisms in your body do not work properly / at all under theese conditions. Edit thanks to Rex Mann for pointing out my error.

[@ludwigvanbeethoven61]

The Substance that keeps you alive simultaneously kills you

[@apparently2]

@@ludwigvanbeethoven61 How's that for ying-yang?

[@bazoo513]

4:00 - Supernova is needed only to disperse oxygen - unlike elements heavier that iron, it is mainly produced by good old fusion inside stars, specifically in CNO cycle.

[@ilikeyourname4807]

If you hadn't commented this, I would have. So now I'm just bumping it up the list

[@magtovi]

This.

[@witchdoctor6502]

Yes, but I don't think it is such a big deal on a channel like this. Its like saying Earth's orbit is round - it isn't, but for everyday life the difference doesn't matter.

[@lavadax2]

Thanks! @Joe love you channel, but next time try to do a bit better on the fact checking.

[@OmateYayami]

@@witchdoctor6502 No, it isn't the same. It's a big difference, it's not like correct within few percent error limit approximation. I think it's somewhat a deal on a channel like this because it's defining the quality.

[@TheOriginalJAX]

Admittedly i already know what joe is talking about before even watching the video on this one. doesn't matter though, I want to know what Joe has come to learn and witness his dread and sense of impending doom play out, priceless. Love you buddy.

[@reubennichols644]

- - - - Soooooooooooo M a n y " " Comments " " within . . . just . . . . . . 2 4 hours . G R E A T Job - - J o e - - at Arousing Curiosity . . . . . . Peaking Peoples Interests --- --- & --- Educating The Masses . I L O V E A L L Your videos . . . . . . even the B A D ones (( heh - - heh - - - j o k e )) . The H U G E Range of subject matter that you are willing to touch upon . - - - B R I L L I A N T - - - . . . A N D . . . Far More Importantly . . . . . . Delightfully E n t e r t a i n i n g . -

[@aytaf5430]

me too

[@brendanvanbiljon3861]

I just realized why this channel is so successful. Joe talks as if what he's talking about is common knowledge, making us feel familiar with the subject. Cyanobacteria, I know right!🤗

[@gen0megen0me93]

There is more, to that. His sense of humor is so brutally honest, that everyone can personalize self scepticism to his dark thoughts :]

[@gabrielgonzalez1993]

Tiny glow friends 🥳

[@ilovegunsandhuntingandradi5912]

@@Elena-xl5dc Wtf

[@brendanvanbiljon3861]

@@Elena-xl5dc Elena, please remove your spam comments. We didn't come here for sex. We didn't come here to satisfy our fleshly desires. No, we came here for something much more precious than that...intellectual stimulation. Intellectual content from this great channel and conversations with like minded individuals who want to explore. Explore, not matters of the bedroom, but of the mind. Yes, we are animals with sexual drives which likes to see boobs from time to time, but we are not just animals. We are more than that, seeking to know why. So please, get your filthy porn adverts out of here.

[@brendanvanbiljon3861]

@@Elena-xl5dc But you make a good point regarding KZbin's double standards.

[@DigitalJedi]

Pro tip: By staying underwater for an extended period of time, the atmosphere can't kill you anymore. I mean, the lack of it will, much faster, but _the atmosphere_ won't kill you.

[@DrPOP-jp7eb]

So true. You can stay underwater for the rest of your life.

[@stevenhetzel6483]

Joe you claimed all elements heavier than Hydrogen and Helium are created in supernova, that's not true. Stars can form up to Iron through fusion, anything heavier than *that* requires supernova.

[@ranjaxwolf9725]

Or a neutron star collision

[@15xgg80]

you must be fun at parties

[@_davidp]

And Uranium is known to be the heaviest naturally occuring element. Humans are resonsible for making Plutonium!

[@inventor15]

The genesis project in the 90's proved that solar flaring produces all elements up to lead.

[@anshi5098]

@@15xgg80 you're on the wrong channel. You'll only find nerds here.

[@matthew.c5578]

“We are in a way, living flame. But the fire fades” - Joe, a man who secretly plays DarkSouls

[@enjyn09]

Literally waded thru the comments section to find this. You did not disappoint. 👍

[@BassRemedy]

ashen one... be sure to bring more souls... 😈

[@c.guydubois8270]

Fuel depleted? Here the

[@MediHusky]

Big oil got him before he could reveal the secrets of eco fuel.

[@juliaconnell]

goddammit Joe you're right - oxygen *is* killing me - going to give up that nasty oxygen addiction right now...

[@ashj_2088]

As I drink my second litre of milk today , you could say I've been addicted to the white stuff since birth.👈🤯👍

[@juliaconnell]

@@ashj_2088 milk? or oxygen?

[@ashj_2088]

@@juliaconnell milk 😋 🥰of course

[@juliaconnell]

@@ashj_2088 LOL the subject of the day is *oxygen* you milk fiend you - milk is very good for you, though an overindulgence is some things (even things like water!) can be detrimental to ones health (check out chubbyemu's channel - I don't think milk is included - but other things are... presented)

[@pinkimietz3243]

Are you still there?

[@mrPauljacob]

I'm an arborist... So I've burned unknown amounts of brush in my life. Even then im never not completely mesmerized by it. It's truly so enigmatic and provoking yet calming and comforting.

[@holdmeclosertonydanza22]

Your hosting skills were always good, but it's been so fun to watch them evolve to where they are now. Your scripts are fluid, your jokes land most of the time, your hosting personality is developing beautifully, and you're really hitting your stride.

[@unexpectedbagel6164]

“It’s probably a big mistake.” Did Joe just reference Douglas Adams? Love me some Hitchiker’s Guide.

[@lisamarie06]

Same! And in two days, I'll be 42.

[@unexpectedbagel6164]

@@lisamarie06 I was 42 last year. Nice.

[@lindaseel8633]

Happy birthday ( even belated ) to the both of you.

[@unexpectedbagel6164]

@@lindaseel8633 44 is coming up a month after Christmas. So thank you!

[@lindaseel8633]

@@unexpectedbagel6164 You are welcome. 🎂🎂🎂

[@StuffandThings_]

Oxygen is one of the most electronegative and reactive elements out there. Its like evolving to thrive in fluorine or something. Kinda crazy when you think about it like that.

[@paavobergmann4920]

yup, cyanobacteria very nearly killed off life as a whole, they barely made the evolutionary race to adapt to rising levels of their own waste.....Now there´s an example to learn from!

[@benjaminbutson1873]

Im impressed the way you explained resperation was very concise as a trainee nurse I can say yoy nailed it with more clarity than my lectures

[@25lover25]

nothing makes you feel dumber than when joe says "now you've probably heard of this before" and you haven't heard of it before...

[@acaaaaaaaaaaaa]

LOL...I Concur...LOL

[@onlyonewhyphy]

Is it sad that I always have?

[@divinedriftofficial]

"more dumb"

[@AncientMysteriesAndInnovations]

That is how to politely be condescending

[@thorin2667]

Ikrrrr

[@kevinrasmussen1748]

You nailed the location of "That video" this time. Been waiting for that to happen. nice.

[@theonetruemadao5207]

You can heal 5 times more quickly in a hyperbaric chamber at 100% oxygen and 3x atmospheric pressure.

[@codename495]

You can heal faster, because the high oxygen is literally pushing your metabolic functions faster. Living is a metabolic function with a finite span, so you’re healing a little bit faster while you’re in there but you’re dying a little bit faster too.

[@theonetruemadao5207]

@@codename495 high pressure saturates your body enough so that it is absorbed by your plasma, this allows your blood to carry it far more effectively to oxygen starved cells (cells that are damaged). The high concentration of blood plasma stimulates the mitochondria in your cells and attracts stem cells which further increases healing. They use hyperbaric treatments on burn victims and radiation wounds, because it increases collagen and skin cell growth. There hss even been a study done in israel that found that hyperbaric treatment increased telomere length and decreased senescence cell concentration (cells damage by oxygen damage). The study had positive results and now rich people are queuing up to get their possible longevity treatment.

[@theonetruemadao5207]

@@codename495 LeBron rents a hyperbaric tank to help him recover after training and I read that Justin Bieber sleeps in one.

[@edgregory1]

Especially burn injury.

[@yancgc5098]

I think I prefer slower healing over getting lung damage from oxygen toxicity

[@sky.the.infinite]

“I’m not talking about that immanent feeling of doom… (relatable smirk of disparaging truth) although it’s there.” GOLD.

[@CartoonHero1986]

Ever seen the meme about "Planet of the 'slow burning'"? It was one of those existential joke memes to explain why aliens might avoid Earth because we are all slowly burning and breathing poison like some kind of freaky demons lol

[@dominicthompson82]

Can you send me an example? That sounds cool but I'm not seeing anything

[@zach....]

@@dominicthompson82 The way I've heard, and retold it -- Imagine an alien ship exploring and passing by our planet. Some of our space travel technology, which would likely be primitive to the aliens, uses a hydrogen and oxygen as fuel in a reaction to cause combustion and thrust. This process also combines the hydrogen and oxygen and makes water as a byproduct of the reaction. So these aliens show up, scan the planet, and notice sentient creatures breathing in one part of primitive rocket fuel (oxygen) as a requirement for life, and then drinking the fuel byproducts (water) as a further requirement for life. Continuing the examination, the entire planet seems to be growing on the rotting dead of the generations that lived before it. And these sentient creatures seem to cultivate the mass of rot by pouring rocket fuel byproducts on it, and then eating the fruits that grow. Just a terrifying sight of fuel huffing cannibals. and this is the answer to the fermi paradox. we're gross.

[@gamingcreatesworlddd2425]

@@zach.... every civilization have ups and downs those aliens will also have transformed from gross similar beings to idk technologically advanced beings

[@ryconroleplays]

Holy crap haha I was second camera on Nigel Blows Stuff up. Happy to see it having a second life on Curiosity

[@Ahad_Faisal]

RYCON I WATCHED ALL YOUR KENSHI ROLEPLAY VIDEOS!

[@acl61]

Ha! The lightning episode was filmed in my high voltage lab. Nigel got so many electric shocks.

[@laurawoodward3046]

Random. I thought he was a child psychologist?!

[@ryconroleplays]

@@laurawoodward3046 yeah he is but he's done a bit of science communication too

[@Orangefootcat]

1:05 is the plot of dark souls in one sentence

[@adrianspickler391]

I love your channel. Keep up the good work. It is also interesting in an "Oxygen is killing you" video to mention Oxygen Toxicity in Scuba Diving. This is where high pressure causes oxygen to be even more toxic. That and Nitrogen Narcosis ends up requiring a third gas, helium, to help keep from dying. See trimix diving and partial-pressures-of-oxygen for details.

[@Yasen6275]

For one not paying attention in chemistry classes, you've got it right and mostly complete. The only thing I'd like to add is that oxygen molecule is free radical too.

[@wulf2121]

no, its not. in an oxygen molecule each oxygen atom has 6 electrons + 2 shared electrons, which gives it a shell of 8. But the bond is less stable than oxygen to something else, which makes it so reactive (but still less reactive than a true free radical). Or perhaps you meant a single oxygen atom is a free radical, too?

[@Yasen6275]

For the knowledge that was relevant before quantum mechanics, what are you telling is true. But knowledge has evolved since then. Check wiki page for radials and especially diradicals.

[@wulf2121]

@@Yasen6275 Ok, interesting, so it would be technically more correct to write ·O-O· for the structure of O2 instead of O=O like its commonly written, since the first one is actually the more stable form according to wikipedia.

[@ElectronFieldPulse]

@@wulf2121 - What? From my organic chem classes which were admittedly 15 years ago, oxygen molecules form with a double bond. Pi orbitals merge to create a common pi2 orbital that have 2 electrons in it. You are saying that the oxygen molecule instead has an unpaired electron on each atom that doesn't create a shared orbital? How is that thermodynamically more stable than a shared orbital?

[@Yasen6275]

​@@ElectronFieldPulse I'm afraid that classes you were given 15 years ago were outdated even then. With about 50 years, if I remember correctly. Pi and different sp orbitals are good pedagogical tools for beginners in organic chemistry. But they are mostly misleading when one must comprehend implications of quantum mechanics in electron energy levels of molecules. 1. Thermodynamics has nothing to do with electrons, there energy levels in atoms and molecules. 2. All atom orbitals are more or less transformed when atoms became part of molecule. Newly formed molecule orbitals that are more or less covering the whole of molecule. In case of the O2 molecule these unpaired electrons are on two molecule orbitals enveloping both atoms. And these orbitals have equal energy. To blow your mind even more these two orbitals have energy levels higher than any atom orbital in oxygen atom.

[@dallas4914]

Your background reminds me of an eye spy book ! Love it

[@colliersmith5499]

So poetic and then starts talking about “bacteria farts”

[@lindaseel8633]

That's our Joe.

[@FinalPattern11]

The burger closer was nothing short of brilliant. Timing - perfection

[@Zatticzattic]

I feel you on the drawing in chemistry class instead of paying attention. I made a flip book out of an entire book of post it notes instead of paying attention. Still passed somehow, and I still have the flip book, so thats something

[@ElDJReturn]

Thats such a Win Win

[@ChessMasterNate]

Human aging is a heck of a lot more complicated. In fact, they have found that higher pressure oxygen in a hyperbaric chamber can extend telomeres in the blood, likely extending life. Quantum tunneling as a result of the heat producing bonds that otherwise are not energy favorable is a major source of aging (by probability, several photons of heat energy concentrate in a localized area providing the energy for the damaging reaction which is more common at higher body temperature). This is why most of the organisms that outlive us are colder than we are. We can't just choose to be cold, and live longer, though. We have enzymes that are required for even the most basic cellular operations, such as the reactions in mitochondria that produce ATP. Those other organisms have different enzymes. So they can endure internal temperatures that would kill us. And while this is a major form of aging, it is just one of several. We accumulate a protein called Glucosepane. It is a lysine-arginine protein cross-linking product and advanced glycation end product (AGE) derived from D-glucose. This makes a mess of collagen in our bodies over time. The other AGEs, as long as we produce and ingest relatively small amounts (by avoiding things cooked at high temperature, whipped, churned, ground or otherwise processed at high speed by machine, or fermented, and by having ample vitamins) can be processed by the liver (as long as the liver stays healthy) and expelled by the body. This Glucosepane crap could probably kill you just by itself, by stiffening tissue, so much that it no longer functions. Then there are toxins that accumulate in your blood. That can be removed by plasmaphereses. But who does that just to clean their blood? Then there are changes to molecules that connect to our DNA. This methylation aging we have no way to reverse without killing you...yet. And if we could turn back that clock, how would we do it uniformly? What happens when you have cells that all think they are different ages? The ends of chromosomes shorten with every cellular division. When the chromosome ends (telomeres) reach the end, the cells can no longer divide, but more than that, they can become nasty. They can start to gorge themselves eating other cells, and spewing chemicals that kills and harms other cells. These senescent cells also accumulate as more and more cells run into their division limit (Hayflick limit). There are things we can do to reduce the number of these things like periodic fasting or near fasting, and taking senolytics like quercetin and fisetin periodically, but it is almost certainly a loosing battle. Mitochondria can also go bad making a mess and killing cells accelerating divisions to replace those damaged cells, which makes more cells run into that division limit. Though, it is possible to refresh your mitochondria by doing very unpleasant HIIT (high intensity interval training) exercise very regularly. And while hyperbaric oxygen and a few molecules we have found can extend telomeres...that is probably limited to the immune system and the blood. Anything further reaching, probably would require genetic modification.

[@christopherhall5361]

People bad at chemistry: "Oxygen is flammable" Me: *Slap* "NO IT'S NOT"

[@Lethgar_Smith]

Oxygen alone cant fuel a fire but it is a necessary component to the combustion process and a pure oxygen environment significantly increases the reaction rate of a fire and can lead to an explosion This gives it the appearance of "flammability".

[@themeanestkitten]

The Oxygen tanks have been lying to us all this time!😱

[@thoughtsofapeer]

@@Lethgar_Smith You don't need oxygen to feed fusion. Maybe the sun is not on fire after all

[@lucasbiermann257]

@@thoughtsofapeer well fire is plasma right? since it reacts to magnets and all

[@ГеоргиГеоргиев-с3г]

Being "Flammable" is oxidation and releasing energy, So mono atomic oxygen is "Technically flammable". The creation of ozone needs energy (as far as i know) so that isn't, unless you use O4(if it can be created) in which case it should be?? I think i found it oxygen is flammable , you just need O4!(Ooor maybe not)

[@charlesgichard9864]

When you said "let's start with what we already know..." and that catchy drum and bass riff started, it was just like when I have to think about stuff I already know about. Do do do do do, I already know this, I don't have to learn right now, do do do do do

[@joshmellon390]

Dude I fucking love this channel. Some of you guys deserve to be nominated in some of these yearly awards shows. Like, your decapitation video; That should receive an award lol. Fuckin' great work Joe, great work.

[@MountainFisher]

Not a really good job, it was a piss poor history of life on this planet lesson. I'm a retired biologist/engineer and the oldest confirmed fossils of life are the stromatolite fossil beds in Australia over 3.5 billion years old. Cyanobacteria that is photosynthetic made the stromatolites, a prokaryote bacteria. Nothing much before that 3.5 billion year line is confirmed and is always possible a natural process made the fossils like the so called Life fossil in the Mars meteorite. It looks like it might be life, but it is too small and could be a simple calcite evaporite. Did you also not see the big contradiction? He said the other way for oxygen to be created is for sunlight to shine on water vapor and water has been on Earth for at least 4 billion year and longer so for millions of years there has been some oxygen in the atmosphere. Oh! Don't forget lightning tearing H2O apart as well. That eliminates life forming processes as there is an oxidizing processes going on. Also almost half the Earth's crust is oxygen in the form of silicates. The lithosphere is 46.6% oxygen by volume present mainly as silica minerals (SiO2) and other oxide minerals. According to geologists the so called primordial soup never existed. Of course there really isn't any natural processes that can form life in nature except life. Life only comes from Life. Only a metaphysical assumption says Life can come from non-Life.

[@yxzuk9214]

@@MountainFisher deez nuts

[@MountainFisher]

@@yxzuk9214 What is that supposed to mean?

[@reubennichols644]

- - - - Soooooooooooo M a n y " " Comments " " within . . . just . . . . . . 2 4 hours . G R E A T Job - - J o e - - at Arousing Curiosity . . . . . . Peaking Peoples Interests --- --- & --- Educating The Masses . I L O V E A L L Your videos . . . . . . even the B A D ones (( heh - - heh - - - j o k e )) . The H U G E Range of subject matter that you are willing to touch upon . - - - B R I L L I A N T - - - . . . A N D . . . Far More Importantly . . . . . . Delightfully E n t e r t a i n i n g . -

[@davidanderson_surrey_bc]

Seriously, Joe? You pinned this vulgar remark?

[@BenjaminKibbey]

I love how you explained the role of oxidizers. Fire in all its forms is truly fascinating. However, in the interest of being pedantic, because everyone loves pedants, smoke is actually the product of incomplete combustion, which means, simplistically, that there is more fuel than the oxygen required for complete combustion at that temperature. In other words, smoke is fuel, and combustible in a similar manner to propane or natural gas. It's why if you come on a building that you believe is on fire and a room appears to be filled with smoke when you look through the windows, you NEVER break that window, because the only thing missing from that room being a giant inferno is more oxygen. In contrast, if you ever look into "rocket" stoves that some permies use, they have to be super, super careful about carbon monoxide because the more complete combustion produces no visible smoke. In other words, you could have a chimney leak with a normal fireplace and likely catch it due to the smoky room, but with a rocket stove, you just die from the CO if you don't have a detector.

[@Sephiroth36977]

For years when someone asked how I was doing I would answer "Still breathing, haven't managed to kick that nasty oxygen habit yet!" This video taught me just how scientifically correct that statement was. Also, this was the best explanation of "free radicals" and anti-oxidants. I wanted Chemistry in high school science but was placed in Anatomy which was no where as interesting to me...

[@the_curiosity_project]

Just learned about this in Biology. I didn't understand any of it until this video. Thanks joe

[@sziauddi]

@2:54 methane is CH4 not M

[@cricketman7335]

0:32 - 0:39 ... I'd love to know where that particular stock video of burning wood can be found! So calming, yet invigorating at the same time. Perfect Zen viewing on a digital display.

[@andreask.2675]

"They can hold our attention as well as any TV show"??? Well not the ones with the 24/7 fireplace! :'D

[@bramvanduijn8086]

Real fire still wins.

[@NadavForMe]

I want to suggest few corrections: 1. You talk about combustion and oxidation. Many elements can accept electrons and act as oxidizers. to name a few: Nitrogen, Chlorine, Sulfur. combustion is the name for oxidative reaction specifically with Oxygen. 2. Iron Oxide is called this way not because it was oxidized (participate in a reaction in which other element oxidized it). The naming system (nomenclature) for simple salts is: [name of the cation element = Metal] [name of the anion element = Nonmetal]-ide. just like Sodium Chloride. 3. Cells create free radical in some of the cell metabolite. These radical are often use to desirables reaction. This happens even without any negative influence. The radicals are often Oxygenic molecules, but this is not mandatory. 4. If we talk about Oxygen and combustion so much, I would talk about the reason all this Oxygen doesn't burn everything. Oxygen (O2) is extremely reactive molecule, but it's electron configuration makes it more difficult to react with other molecules. I don't remember exactly why this happens, but it has to do with the spins of the two reactive electrons of the molecule. In it's triplet (stable) state the two electrons have the same spin. In the singlet (exited) state the electrons have opposite spins. I know that's a lot, but please don't despair. Chemistry is beautiful and I love seeing videos related to chemistry. Keep up the good work :)

[@Stacey0909]

Love, Love, Love ....your content & sense of humor ✨ 💖🙏💕

[@Erchyful]

I love his simple way of explaining, adding a joke or two and talking on a normal volume (no shouting like some). Thank Joe! Keep it up 👍 👏👏

[@davidanderson_surrey_bc]

Lots of oxygen: Will kill me in about 80 years. No oxygen: Will kill me in about 80 seconds.

[@rootdefault6263]

All I can say is don't stop doing what you do Joe. It's a lot of work to digest years of research but your helping soo many people be more aware. (the emoji looks like am flipping you off but am not LOL! it's a thumbs up.)

[@JamesSchriever]

There is actually a fourth requirement for fire: Pressure.

[@stephaanjacques2269]

very good point sir

[@jobr1751]

pressure from air... that contains the oxygen, yes.

[@Tubeytime]

There's actually actually a fifth requirement for fire: The Higgs Field.

[@Druzym00n]

I work in healthcare and you can actually give someone oxygen toxicity if they’re given more oxygen than their body can use. One of the side effects is difficulty breathing

[@Games_and_Music]

Ren & Stimpy made me aware of the effect of oxygen, albeit viewed from a somewhat different angle, haha, but it did start making me think about oxygen in general. It's really just a bad joke, but here goes: Muddy Mudskipper to Stimpy: "Ever breathe oxygen son?" Stimpy: *_inhales to respond_* Muddy: "Good, don't start! Me? I'm hooked! Get it?" (because he's a fish, although he's a lungfish..) Stimpy: *_inhales another time to respond_* Muddy: "Shut up!"

[@alphagt62]

Muddy: “Ya lousy bum”

[@Games_and_Music]

@@alphagt62 haha

[@alphagt62]

@@Games_and_Music Muddy was my favorite side character! I worked for a cigar chewing old man who was just like him when I was young.

[@snf6677]

Gonna nitpick a bit. At 8:10 glucose doesn't exactly "get transformed into ATP", rather it gets oxidized into CO2 and that reaction's energy makes ADP into ATP. Yes I am fun at parties, why do you ask?

[@RealStuntPanda]

My chemistry professor loved to tell this joke, "How can you tell oxygen is a trollop? It'll bond with anything."

[@fredbloggs5902]

If he told that joke today, he’d be immediately hounded and eventually fired by mobs of twitterati lefty SJWs.

[@thomashiggins9320]

@@fredbloggs5902 Sigh. Crawl back under your rock. No "lefty" would care about such an innocuous joke. Real abuse and discrimination take up all their time.

[@fredbloggs5902]

@@thomashiggins9320 Your claim is provenly a lie, but stay in you bubble, eventually they’ll come for you.

[@iamcyber]

@@fredbloggs5902 ur stuck in a right wing bubble and still think people who are just leftists are 'crazy radical SJWs" grow up

[@fredbloggs5902]

@@iamcyber Professor Ned Lebow

[@starria_8744]

admittedly, this video makes me scared to breathe..but nonetheless it's awesome! my friend recommended me to you joe, and now i cant stop watching!

[@Sigma00000]

I loved all the random jokes, mentions of existential dread, spontaneous "woo woo", and how the cyanobacteria made the worst mistake bringing about humans. Love your sense of humor

[@john-ic5pz]

I'm not encouraging you to self harm. I just don't understand why folks who say humans are a virus or a mistake or cancer don't contribute to correcting the "mistake" and take themselves out. rather, they whinge about it on social media. can you enlighten me about this strange phenomenon?

[@michaelransom5841]

Ya.... the oxidative stress theory of aging or the free radical theory of aging has kinda been disproved, sort of. I say kinda and sort of because it does play a role, and is a contributing mechanism, but "observed correlations between ROS damage and aging are not necessarily indicative of the causal involvement of ROS in the aging process but are more likely due to their modulating signal transduction pathways that are part of cellular responses to the aging process." to quote Wikipedia. Basically, the short version is that, under ideal conditions, our bodies have developed the ability to mitigate any and all damage from ROS. When functioning properly, our bodies are so good at managing oxygen that we've come to depend on ROS for a number of biological processes including proper mitochondrial function and the use of ROS as chemical weapons by our immune system. The reason oxidative damage is so well correlated with aging is because the "aging process" damages the systems that repair and prevent ROS damage. The break down of these systems both allows oxidative damage to accumulate, and increases the rate of further damage in a sort of feedback loop. So yes, it pays a role, but it acts as more of an indicator and modulator rather than a primary cause. In theory, if you could prevent or repair the cellular damage to the ROS management systems, then you could go on indefinitely without accumulating any ROS related cellular damage. So its not really the oxygen that's killing you so much as it becomes one of many factors as your body begins to experience age related decompensation away from homeostasis, and rather than oxidative damage, the growing consensus is that this is driven primarily by epigenetic alterations which interfere with protein synthesis. www.ncbi.nlm.nih.gov/pmc/articles/PMC3901353/ www.frontiersin.org/articles/10.3389/fcell.2020.575645/full www.scientificamerican.com/article/is-free-radical-theory-of-aging-dead/ www.lecturio.com/magazine/aging-epigenetic-alterations-and-loss-of-proteostasis/ www.hindawi.com/journals/sci/2020/1047896/

[@Benson_aka_devils_advocate_88]

My buddy had an oxygen bottle for welding with an advisory sticker on it warning of the increased risk of cancer from inhaling it. It's a good thing us humans aren't dependant on oxygen when going about our daily lives!

[@MortyMortyMorty]

What about Hyperbaric Oxygen Chamber Therapy?

[@fredbloggs5902]

The humans who got bored watching the fire and wandered off... ...got eaten by lions, tigers and bears. Evolution in action.

[@nickkopelgaming]

I found this channel a week or two ago and I just keep binging it, watching for hours at a time. I love every video and I think I found my crack.

[@Endrw]

can't wait for all the people watching to start breathing manually because of this video

[@alidamullakkara]

Omg yeah. This made me conscious about my breathing xD

[@KorsarNek]

I did just after reading your comment...

[@CT-um7zq]

Try getting really ill🤧 I never, EVER, gave a thought to my respiratory pattern, until I got sick and I had to consciously breathe. At one point you get tired and your O2 drops like motherfucker. You can't even sleep because it sends you O2 into the 60s. Scariest week of my life, altho not as scary as the hospital bill, which is why I didn't go to one. Somehow I survived and now have PTSD. I can't see anyone sniff or cough near me, without me getting the Lysol aerosol bottle out of my bag and aim it their way. Either to spray them or hit them over the head for spreading the plage, it's a matter of how lucky they get.

[@davemccombs]

I'm already subbed but damn, I just realized that "the future of war," "heavy industry in space," "6 historical figures/not existing," etc is the perfect blend of scatterbrained nerd shit that I feed off of, lol. I love that it's part standard fare science-y channel, but also a dip into some appreciative history. Having fun with some of the latest vids! I think the high sub count yet very modest feel is welcoming. Keep that flavor! And make the next one WEIRD. Cheers :)

[@cibarra294]

Joe, I wanted to be a smart fella. But society made me a fart smella.

[@lucidmoses]

Nice no-nonsense description of the process. Nicely done.

[@tobi_versace]

The intro was great!!!

[@chriswood572]

My other favorite KZbinrs , SECURETEAM and Missing 411/ Cansm Missing Project. You had a show on addiction once. Great show. The sub skit was great. Every skit you do is always funny .

[@Stang_Gang_8]

This video reminded me of my research on the fork-head transcription factors, which I wrote my senior thesis for my BS in biology on. I was looking into genes that promote longevity of life. Essentially the fork-head transcription factors are proteins which are active when your body is in a basal state and they function in cleaning out free radicals and fix denatured proteins. I would suggest looking into it, might give you a great video topic.

[@chriswood572]

Hey brother, I’m Chris and I watch your show a lot. You know , I thought that you were like a science channel show. Like a Bill Nye the Science Guy . What I mean is … you got a lot of talent. Ur funny , clever and very well spoken. Your show is highly entertaining. It took me some time to realize that you were an actual KZbinr type show. Anyways don’t ever give up what you’re doing because you’re made for this. You have a Lot of talent like I said. if anybody gets bad responses they are probably just jealous or envious. The world is full of that as we have seen with our past president that people just didn’t like but you get what you vote for Hope they’re happy now. I’m a 50-year-old man and I find your show highly entertaining and does always make me feel good when I get done watching your show. Hope you keep on keeping on .

[@sinebar]

My chemistry teacher in engineering school described fire as rapid oxidation that is so fast it produces enough heat to create plasma.

[@falazarte]

3:52 "Probably a big mistake " LOL

[@stufromoz8164]

Thank you Prometheus we appreciate what you went through for us.

[@KrazyMO]

You’re literally one of a few KZbinrs I can watch at normal speed. That’s a compliment fyi.

[@jackd1582]

He mustn't be from the south

[@leslieshaw1421]

Man, all the drawing I do and I can’t get good at it either! I so felt you when you said that. Luv ur show. Thanks Joe and google.

[@treydonnell2871]

I love that I knew the wee woo bell was coming.

[@davidmiller9485]

I just had this conversation with my wife a couple of months ago. Most people just don't think about oxidization nor it's effects enough.

[@alexv3357]

3:46 "In the beginning the universe was created. This has made a lot of people angry and is widely regarded to have been a bad move."

[@Priya-cm3tr]

Interesting. Basically in Indian civilization, most of our rituals, Vedas (=knowledge) and philosophies revolve around the fire which is the "prana tatva" meaning source of life. Eg: The marriage happens around the fire to bind life energies or we chant mantras to produce specific vibrations and concentrate on the fire, many kinds of Dhyaan (meditation) involve fire. Also for eliminating internal ailments we have whole science and books written revolving around controlling breath (basically how much oxygen moves in and out - where it goes, how much to hold and release etc) a practice which is called pranayama. Whatever you said seemed like basic knowledge to me but it's good to see things coming together even from a western perspective. Even many modern-day Hindus/Indians are oblivious about the reasons for many things that are civilizational heritage. Just imagine after 5,000 years the world wouldn't be the same, continuity would be broken and most people won't even understand what western civilization had achieved and would call it "myth"/legend or corrupt whatever knowledge they manage to retain. Time is cyclic and I hope the west could move away from its linear view about the world timeline just so it can claim greatness because many civilizations were a lot older and advanced than this one until they committed one fatal mistake.

[@TheCreator1197]

Redox Reactions! Combustion [Ordinary Fire] Respiration [Living Fire] Rust [Slow Flameless Fire]

[@kiwibonsai2355]

Nigels docs are awesome, he's the man for waking up those that are blind to the facts. Cool to hear the shout out. 🇳🇿🇳🇿🇳🇿

[@velupillairajaretnam5516]

No chair swivel and drumbeat at the beginning?!!! Which channel am I in?

[@locustkllr]

This video needed a clip from the movie "The Road". No spoilers but near the end one character asks another about "the fire".

[@crazysquirrel9425]

Seems it boils down to this: We 'borrow' oxygen. But it seems oxygen investment is diminishing returns.

[@benferm150]

This. The absolutely most badass way to ever do a crazy thing around a bunch of extremely serious things people are constantly thinking of. For heavens sake, man, in a funny matter said. This is the way to do it! I'm out of words, and words are my business.

[@davidanderson_surrey_bc]

Today's episode was a breath of fresh air.

[@escobyte]

Please do an episode on Bird Law 🙏🏿

[@bigeatah_official]

I love you Joe, you’ve taught me a lot, like sure your not a scientist store historian or crime expert but you hand us Knowledge and give us things to look at to help us not only widen our minds and intellect view, but help us grow and not be in a little bubble and toss out things we don’t like. Thank you Joe

[@sophiajaye7706]

"Mabye we are just moths" this touched me

[@Pettingson]

Damn Joe. This episode is on a "Vsauce, Michael here" kind of level how it brings us back and fourth teaching so much different things that have with eachother to do :D Much love!

[@ammosophobia]

They say that time is the fire in which we burn.

[@calinculianu]

@Joe Scott -- It's not just sugars, you can metabolize FFAs (free fatty acids), ketones, and amino acids directly for energy using oxygen. In fact, people eating a low-carbohydrate diet are metabolizing mostly fatty acids and ketones for energy. The "your body burns sugars for energy" is an often-repeated thing that is just incomplete/wrong. The only pathway exclusive to sugars is, oddly enough, the anaerobic one (not requiring oxygen). Anaerobic respiration is exclusive to glucose in humans.

[@anthonyinzerillo3882]

Love the science stuff, but Joe's weird & history topics are great.

[@sweatysam6264]

Watched this on my 15 min break gotta get back peace.

[@SlashRfnR]

I like seeing Joe staring into the abyss while contemplating about wise oxygen

[@Glitterkins_the_sparklemonkey]

That intro was powerful. 🔥

[@oscarraygoza4350]

And there's nothing better than having breakfast while watching Joe's video and relax until you go to work

[@haffa777]

This introduction was really nice!

[@OllieWheats]

"maybe we're just moths". The serious tone in which you said that, brilliant.

[@normrhett7608]

Reactive oxygen species have many roles in immunity. A deficiency of them from excessive consumption of antioxidants can contribute to tumors. My own experience was a skin lesion that wouldn't heal until I stopped taking CoQ10 and alpha lipoic acid.

[@bbirda1287]

Fun fact: During the great Oxidation Event, the new oxygen emitting bacteria not only killed off the anaerobic ones, but themselves in several rounds of great die offs until they developed sufficient resistance to oxygen. There are several great videos on the tubez that delve more in depth, awesome watch. But a great overview video, a lot of stuff to pack into 15 minutes.

[@infoscholar5221]

Great stuff, Joe. You're inspiration to my own meagre, fledgling channel.

[@fredchevalier2333]

5:05-5:11 Thank your! I have ask myself these questions a lot and am too lazy to do the required research to fully understand why

[@dillonphillips313]

Never realized. Thanks, Joe!

[@renaldocargill3800]

I found this out years ago when I was in elementary school! And by God! My mind was blown for like a week!

[@brianwilliams3001]

Joe. Good job getting back to the roots. I'll pay more attention to u.

[@koun582]

Now that was one hell of an introduction 😭👌🏾

[@carpemkarzi]

Best way to start the week. Thanks Joe