Parkinson's Pharmacology

[@levioneverything4847]

Great vid Dirty. One small caveat: remember, Entacapone is only effective in the peripheral circulation, it can't cross the CNS. Tolcapone however can be used to inhibit COMT in the peripheral circulation as well as the CNS.

[@scottjohnston5049]

I had the same comment plus an easy way I remember - tolcapone works in total (everywhere), while entacapone works only in the enteric[ally-dominated] peripheral circulation. The capone aspect with the crimes mnemonic is spot on

[@williekimler4324]

I was literally coming to right this out. perfect vid just one small mixup

[@طيبةيونساحمدحسن]

@Ashley Echeta wow amazing

[@beratakn6007]

@Ashley Echeta That's great

[@strongDr]

​@ashleyecheta1857Ashley I Love You❤

[@J1Sulliv]

DA Receptor Agonist mnemonic: "It would be Dope (dopamine agonists) if my Bro (bromocriptine) could Rope (Ropinirole) in Pam (Pramipexole)."

[@طيبةيونساحمدحسن]

Wow its great

[@nonyzaki-988]

I just found out about this channel / i want to say this guy makes a great reference for future. People will have the chance to get any answers for their questions so fast and easy . Im so happy because we still have a good guy with kind heart 💙 love to help people with his knowledge . Thank you for the effort you did . By the way I'm psychologist woman from EGYPT 🇪🇬

[@theodule01]

Whenever FA is too hard to understand, Dirty to the rescue! Many thanks bro!

[@yoseftarshis7518]

Awesome! Small correction though, The only 3-MT inhibitor that works in the brain is Tolcapone. Both Entacapone and Tolcapone work in the perifery. Keep up the great work!

[@kaiwenchen2258]

Going off this, I remember tolcapone can cross blood brain barrier because you can pay a "Tol" to get through the barrier

[@milesbrooks5747]

Yes! i literally have a test on this in 90 min 😂 thankyou

[@ramaos8542]

How was it 😂

[@anonmeatcheesebun]

LOL YOUR VOICE when you were talking about Acetylcholine I love you man please never change. I'll be watching your videos long after I graduate :)

[@ruaaz.abdulhussein7127]

I like this guy he make my Pharmacy school so easy. Thank you.

[@HarunDZN]

great video, are you planning on doing one for immunosuppressants? cyclosporine, tacrolimus etc. think it would be super useful

[@visitworldh2482]

Thank you Dirty Medicine KZbinr, for your intersting presentation on medications used in psychiatric disorders!!

[@AyeshMedic]

You're a Blessing for Med students Man!!!!!!! ✨☺️👏🏻

[@redache467]

Amantadine used to be a treatment of influenza virus.

[@TheHyperMD]

You are usually amazing with your teaching skills but this is a different level of good! 🙌

[@anonymous5703]

You are DA-best!!! Thank you

[@qamarhejazi7766]

You’re a mnemonic ninja. Thank you dirty medics ❤️

[@jeremiahbaker6396]

can we give him a round of applause 👏

[@andreathompson-fuller1387]

A classmate mentioned you during a TBL..... all I can say is that 1 hit and I Am HOOKED! Thank you for this. Can't wait to see and hear more!!!!

[@lucyalvarez1288]

Wow, love the Al Capone one🙏🏼

[@danig196]

Maybe for the dopamine agonists: Bros Rope DoPRAMine? Thanks for all you do, your videos are golden and hopefully will help me pass Level 1 in a few days...

[@katecataldo4398]

"A PBR would increase my dopamine." They're nasty, sure, but even a PBR would be better than studying for Step.

[@gaylegonzalez71]

Love all your memory tricks

[@rashidchak8945]

what a wounderful style of teaching,pls continue.

[@طيبةيونساحمدحسن]

Luv ur way in the delivery of the information thank u sooooooo much.

[@francishubertovasquez2139]

Or if enzymes creates biochemical reaction then focus as well on enzymatic actions reversing their every reaction for the treatment cause.

[@williamrosaleshernandez4174]

Awesomes classes. Never seen before. Thank you so much. Of course i will donate.

[@kaylas620]

Thank you for this!

[@marishabelova3706]

So much loveeeee u r amazing may god bless u

[@loliwemoyo5680]

I remember DA agonist thinking about how a Parkinson person is moving slow so I use my Pram using a Rope tied to a Bromo/Bronco.

[@drwakenyanabiswa9789]

Good stuff

[@keitymarley733]

Parkinson disease is a very terrible illness, my Dad suffered from it for 19 years until we finally got a help and a medicine that truly works that helped treat, cure and reversed all his symptoms... My Dad is well again…

[@eliejoseph7382]

Thank you so much.

[@AlisaJiangYan]

very clear and informative! wow

[@marcelootorrino]

Sweet! How you can make it ease! Genius!!! 👏👏👏👏

[@Gkaur27]

your videos are so helpful, thank you so much!

[@deegallarupananda6927]

Thank you so much! Very helpful video

[@Janayoonie98]

Thank you

[@osamaal-faqeh3462]

thanks a lot ❤❤

[@Mkhan-tl3yx]

Great sir rock❤❤❤

[@skategenie]

I just liked the video before even watching it because I know it'll be koala-tea content

[@GadgetStar-1]

Thank you so much @dirty medicine. It helped me a lot to organise my concepts in shorter time.👍

[@amalj6605]

Thank u Very helpful video

[@deepthiketha9111]

amazingly explained....

[@ABDSHMHD]

thanks sir for your wonderful explanation if you don't mind i wanna ask you instead of giving trihexyphenidyl as Ach inhibiors can we use anticholinesterase inhibitors (pheostigmine, neostigmine or arminium)? thanks

[@francishubertovasquez2139]

What if the blood brain barrier was partly destroyed due to injury or over hypersensitivity reaction of the immune system by autoimmune disease, whats you gonna do coz everything will be mixed up if that happens, thats why to regenerate cells and regenerate blood brain barrier quick is one of the best treatment.

[@drnurzedu9146]

Hi, want to ask. My mother is a parkinson patient got dyskanesia after eating the medicine. How can I help her to reduce that?

[@darkmoon3646]

I love this mannnnnnnnnnn, thanks man

[@tinashealthbeautyworld8396]

good job

[@AlexandraLacy-kk8fb]

the BEST

[@puneetk549]

You are amazing!!!

[@ilkelambrechts4522]

Is Entacapone not only in the peripheries? And Tolcapone is central and peripheral?

[@pranabkumarbiswas7285]

Beautifully explained

[@katiecarr7742]

You rock!! Thank you so much!

[@nourar7944]

‏Can you do videos on anti-epileptics drugs and sedatives /hypnotics and anxiolytics drugs pls

[@maryamnour8801]

LOVE YOUR VIDEOS

[@francescopiscazzi3052]

You're very impressive !

[@taha20raha]

❤

[@tamarazvarayi3955]

the best

[@racsonyc7911]

I love you.

[@abhijitphukan1440]

PRAMipexole- do PRAMINE agonist Ropinirole (rope) sounds like DOPE agonist

[@Invisiblebullet89]

What about people who don't have parkinson but use Trihexyphenidyl/ ARTANE just to get high and increase dopamine?

[@khouzaymaboustani590]

Thank you very much))))

[@michellwilliams8436]

thank you

[@francishubertovasquez2139]

Can the CRISPR defective genes cutting be applied to elderly, if not yet, then work on that.

[@francishubertovasquez2139]

Can the pineal gland ultraviolet energy storage be shunted or channelled as dopamine treament in the brain itself by continually recharging pineal gland energy containing Dopamine because ultraviolet rays have Dopamine

[@francishubertovasquez2139]

The Mechanism as basis for Parkinsons drugs to treat that disease, then why over obsessive with able to predict the course of the Parkinsons disease when various changes occurs in a persons lifetime and existence. Things were attempted to be designed to be rigged but in reality things changed in the human body as the person exposes himself to various factors such as the food that person eats, the age factor, the environment that person mingled, the occurrences within the body like the Genes, the chemical factor etcetera so being rigged in a state was like the behaviors only, the way they react only, the programs only or the systems a particular environment being indulged only, the best method is to deal with the predictable and the unpredictable factors.

[@vanillaICEEs]

Omg I love you thank you

[@joybarot2142]

Awesome you

[@francishubertovasquez2139]

DNA to RNA, then RNA treated back to DNA like the ART therapy as an example only

[@francishubertovasquez2139]

How about modern laser treatments dissolving those excess brain proteins and neurofibrally tangles without opening the brain, well you already have non invasive gamma knife surgery as an example.

[@hujaimaarab3474]

Please make videos for pharmaaaa plzzzxzzzzzzz

[@francishubertovasquez2139]

Increase Dopamine for Parkinsons and delve into the knowledge of regeneration

[@francishubertovasquez2139]

If genetic mutation branches forward with having new diseases as the new treatments tried to sync and addressed with new treatments thats gonna be almost endless counteract this counteract that oops theres new disease lets make a treatment for that, hows the money doing that, but as things were polarized in the microthings and macrothings if theres forward negative coupled with positive treatment then there could be reversals such as reversals of genetic mutation.

[@missionvision99]

8:41 13:30

[@1w1b237]

First to comment!

[@Frugal_Not_Cheap]

Awesome video! A Man To Dine at the DRIve Thru (AManTaDine: Dopamine Reuptake Inhibitor)

[@OthmanMatar-lp4lt]

Thank you