Pathophysiology of Atherosclerosis

[@BlueCheeseNoFleas]

i'm a 5th year med student and your video helped me understand atherosclerosis way more. clearly. words can not express my gratitude.

[@HealthEdSolutions]

You’re welcome. Glad you found it helpful!

[@michellen.9908]

I watched this video a year and a half ago, and really appreciated it's depth. It explains the process of atherosclerosis better than any other site I have found. But for the past year, I have not been able to find this video to re-watch and it has been driving me crazy (I couldn't remember my original search terms). I'm so happy to have finally found it again. I will definitely be watching more of his lessons going forward. Thank you, Dr. Wolf

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@FrederickCraig]

Thanks Andrew. I've just been diagnosed with stable angina and scheduled for a triple bypass, and the topic has suddenly become fascinating. Thanks for explaining it clearly for laymen. Now, not only do I now have more of an understanding of atherosclerosis, I can now have a more informative and intelligent discussion with the cardiologist.

[@peterday1985]

Thanks! KZbin extends the reach of your talent for explanation to people all over the world

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@othomas94]

Thanks very much Andrew. I liked that you kept the normal anatomy brief at the beginning and then went straight onto the subject of the video. Thank you :)

[@sunish2006]

Hi Andrew your videos are awesome. Keep on posting wonderful articles. Very edicative for anyone in medical line. God bless you for your deeds

[@HealthEdSolutions]

Hi Sunish, thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@lea-annelavoie9485]

I find your lectures excellent and a welcome addition to the information I am learning in class. I like the way you break things down and makes it a little easier to understand

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@googleone9209]

the intuitive, conversational nature is easier to follow than other sources when following just audio. Many thanks!

[@HealthEdSolutions]

You are very welcome and appreciate the kind words.

[@a.u.benterprise6148]

great & usefull... thank you sir for sharing.

[@HealthEdSolutions]

Thanks for watching! Glad it was useful!

[@Nestorgp25Eth]

i have to congratulate you on your very visual and informative lectures. I absolutely love them.

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@genevievechia4681]

BIG THANKYOU for this great visual explanation of the pathophys of athersclerosis! I am studying ACS as part of my post-grad studies in my Emergency Nursing and I found this explanation of yours EXTREMELY useful in understanding the whole complicated process. I love your diagrams... will be copying them in my notes :) Big Hello from Perth, Australia!

[@HealthEdSolutions]

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[@azo820]

i m a pharmacy student and big thank you to you all the way from australia

[@HealthEdSolutions]

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[@PreetKaur-fk3ds]

A great Video as usual, really appreciated.

[@HealthEdSolutions]

You’re welcome. Glad you found it helpful!

[@TheGingerSolider]

very clear, forward and easy to understand, thank you

[@pashleyfication]

I have an exam next week for my Adult Nursing course (Scotland) and your videos are great for revision! The information you give links perfectly to my lecture notes but I am very much a visual learner and so your videos are great for me. Thank you so much for spending time to make them and kindly sharing them with the KZbin community. Oh, and something tells me your view count is going to increase significantly over the next week. My class are sharing your videos on our private facebook page!

[@HealthEdSolutions]

You’re welcome. Glad you found it helpful!

[@lilybogan5036]

Great lecture! You make it so easy to understand.

[@erinmcguire3885]

Seriously amazing talk! Makes it easy to understand.

[@HealthEdSolutions]

Keep watching, we appreciate the support!

[@hcollins67]

Great video made my nursing reading easier and make so much sense. Cardiac is hard enough thanks for making it less complicated

[@HealthEdSolutions]

Thank you for the feedback! Glad you found it helpful!

[@jennygraves3304]

What a great, simple explanation of the process. Thank you.

[@HealthEdSolutions]

You’re welcome. Glad you found it helpful!

[@racheljones6363]

Using your videos for my CR exam in Physio, so helpful thank you very much, my sort of learning!

[@HealthEdSolutions]

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[@miriamw09]

Great video! Thank-you so much. It helped me understand so much better!

[@HealthEdSolutions]

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[@aimanjufri5380]

I suppose it should be monocyte in the vessel and will convert to macrophages later in intima.. Correct me if im wrong :)

[@lithops7370]

Wonderful video! Makes so easy to understand a very important topic!

[@HealthEdSolutions]

Thank you for the feedback! Glad you found it helpful!

[@SaiidiSaiidi]

Excellent tutorials!

[@barakatosman7890]

it is a good idea to see this vedios

[@netaly20]

My prof tolled us to study the kinds of atherosclerosis plaques I was reading Robbins basic pathology book 7th edd chapter 9 and I still dont understand what kinds did he mant . Your help will be so gratitude! Thank you!

[@امانيرضا-ش5ع]

Very good and easy explanation,well done

[@HealthEdSolutions]

Thank you for the feedback! Glad you found it helpful!

[@Cam-xs1xe]

Great breakdown! Thanks👍🏼

[@HealthEdSolutions]

Thanks Cam!

[@rogerlavallee3572]

Excellent presentation - however no mention of the role of calcium deposition within the plaque formation (?)

[@VicenteMReyes]

very nice presentation

[@HealthEdSolutions]

Thank you for the feedback! Glad you found it helpful!

[@fritmore]

Andrew Wolf you did not talk about the process of CALCIFICATION, when the fibrous cap becomes stiffer and more brittle and more prone to rupture. The calcification process also affects blood pressure behavior due to the lesser elasticity of the arterial volume...

[@HealthEdSolutions]

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[@BlueCheeseNoFleas]

really great video keep it up

[@melissa_buchanan]

Wow.. i got more out of that than in my 3 hour class we had on the subject! thank you.

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@armanpouyanpayam]

Awesome video once again. I am just now wondering how can LDL molecules cause inflammation by themselves?

[@MeiraVoirdire]

Wow. That made a lot of sense, thank you.

[@gibsonguitarplayer]

Fantastic explanation……now for the million dollar question……….how do we reverse it or fix it?

[@margeauxkruger569]

great basic intro to atherosclerosis pathophysiology - thanks

[@HealthEdSolutions]

Thank you!

[@Bimpstar]

Such a helpful video thank you!!!

[@HealthEdSolutions]

You're welcome and thanks for watching!

[@benavidus]

Awesome video! i just dont understand how the plaque continues growing under the fibrin, when is not exposed to more LDL... THANKS!

[@VINAY-sw7bp]

Hi Andrew, thank you for the video. How actually can the plaque grow in size after a fibrous layer is formed around the plaque as the opening in the intema is closed by the fibrous layer so how they enter?

[@fayadalfdl7483]

Wonderful lecture

[@ashmortazavi]

Awesome video before a pathophysiology final tomorrow !

[@bonyzan2]

Thank you for the awesome explanation..

[@HealthEdSolutions]

You're welcome and thanks for watching!

[@topraja]

Hello, first of all thank you for the wonderful informative video. I enjoyed it. I was just wondering if you have a made a video about the role of PI3Ks in cardiovascular disease? Thank you

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@yvancsify]

Great lecture! it's true that this visual way of learning makes it sooo much easier than just reading my lecture notes- much thanks! One thing though- at the end of the lecture you mention the clot breaking off and causing an embolism somewhere- can the plaque break off and do this too? Is this also called an embolism?

[@hidayathkhan1900]

THANKS..MADE THE TOPIC SO EASY TO UNDERSTAND

[@HealthEdSolutions]

You’re welcome. Glad you found it helpful!

[@aladinn2002]

Thank you Sir. Your lectures are just out of this world. Am trying to locate your pathphys channel. May God Bless you n yr loved ones. :-)))

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@FiskpisksniskliskNps]

Hi - Could you expand on how DM contributes to the plaque formation, inflamation or maybe the rupture?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@sbreheny]

Nice video. Why doesn't the platelet plug prevent the LDL deposition? Once the fibrous plaque forms, why doesn't that prevent further LDL deposition? Why doesn't the coagulation/inflammation process proceed as it does in other locations and produce proper healing?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@chrismyers7568]

Thank you for this, excellent

[@HealthEdSolutions]

You're welcome and thanks for watching!

[@jenniferstewart87]

This was very helpful, thank you so much.

[@HealthEdSolutions]

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[@martinyoung9901]

Very clear. Thanks very much.

[@bejalpatel7801]

clear understanding!!! helped with my exam

[@HealthEdSolutions]

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[@mohammed93ish]

what an amazing video!! thank you very very much

[@HealthEdSolutions]

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[@Mila-lh9fr]

Thank you, it is a very helpful video. Could you maybe make one about hyperlipidemia?

[@Ruqaiyaable]

very helpful videos .thank u so much

[@romantashevRT]

What happened with the original Andrew Wolf channel???

[@ramalaxmi7468]

it helped me a lot....its a different approach to pathophysiology and i enjoyed ur lecture.i would like to ask u if der is any lecture regarding how tobacco causes endothelial injury i.e by antiprotease hypothesis and antioxidant mechansim.if u included these explanations under any other disease plz let me know.... plz sir

[@HealthEdSolutions]

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[@kurdanayoutube]

Thank u very very very much.... well Job doctor...

[@HealthEdSolutions]

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[@hotpotatovoice2186]

Gr8 work thnx

[@ade2007]

Hi, I was wondering if you could possibly cover physiology of aging? Thank you so much for all your videos and teachings, they are helping me through medical school.

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@Kyrani99]

I found that the key problem is the high blood pressure. If it occurs suddenly and very strongly then a plaque can rupture, and a piece can break off and travel downstream and block the artery.

[@AzureNightsMusic]

Subscribed soon after watching this. such a good revision tool for me, and i'm doing a degree! One question though; after the fibrous cap has formed isn't there another process of 'calcification'? if so what actually causes it?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@sparkles8753]

very helpful! thank you Andrew :)

[@HealthEdSolutions]

Thank you for watching. Glad it helped!

[@mone3ybagz]

thanks alot doctor ***** ... but i have one question after the fibrous plaque formation ...from where does the LDLs come from ?? i mean Macrophages will engulf the LDLs and will grow to some distance ...then how does it keep growing ?? ....or is that the LDL enter in a very large quantity that it takes alot of time to be engulfed by macrophages ?? please anyone answer :D

[@joshuasmith4906]

I believe that the LDL is recruited by the endothelial cells, since LDL contains cholesterol and other molecules that the cells need - after all, the reason that LDL is circulating is to bring nutrients to the cells. Therefore if you have a high level of LDL in the blood over an extended period of time, more of it is recruited and also more of it can be oxidized (this isn't mentioned in the video but oxidation of LDL is pretty bad and can increase inflammation because the immune system recognizes the OxLDL (it can even produce antibodies against it)). Therefore the oxidation of LDL only increases the rate of development of atherosclerosis, since it increases inflammation. Even though the fibrous plaque covers the developing core, the endothelial cells below it still the LDL contents. I'm not a doctor (just a student) so take this with a grain of salt, but I hope that it helps.

[@mone3ybagz]

we're all students here :P ....thanks alot for helping i got it know :)

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@hecarthagoelouaer8029]

THANK YOU VERY MUCH.DOC!!!

[@HealthEdSolutions]

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[@Gheproudbisdak]

Question: in stage 3. Fibrous plaque. You said it won't have contact with the blood stream anymore. So how can it grow in size if LDL's are floating in blood stream? Just got confused in this part. Thank for you videos. It's very helpful and I'm a fan!

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@JacquouilleLaFripouille]

excellent

[@topraja]

Thanks for writing back.

[@douggillard1561]

Very good explanation. Thank you! Do macrophages go into the break in the intima first, or do monocytes come first and then convert them to macrophages?

[@HealthEdSolutions]

Thanks for the question. We've passed it along to the Health Ed Solutions medical review board.

[@luchannleo_7773]

Really helpful, thanks x

[@HealthEdSolutions]

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[@riggy81]

Andrew is the particle size of the ldl relevant or will all ldl deposit in this way?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@arev633]

So helpful thank you. May I please know how hypertension, Hyperlipdaemia, diabetes and smoking cause damage to the endothelial cells

[@HealthEdSolutions]

Thanks for the question. We've passed it along to the Health Ed Solutions medical review board.

[@EvaEats]

Thank you! This really helped me in my nutrition studies. Very easy to understand :)

[@HealthEdSolutions]

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[@drdesha1]

fantastic ! :) :) i love this way of education :)

[@yumattim]

excellent lecture and pictorials. there was a lot of hesitation though

[@HealthEdSolutions]

Thank you for the feedback! We will be releasing a new and improved version soon. Thanks for watching.

[@kaixin90]

awesome video. thanks so much! keep up the good work sir. :)

[@evilherojoseph]

What causes the LDL particles to stick to the tunica intima and get under the layer ? What attracts them ? Chemokines, like what happens with lymphocytes ?

[@imagination7710]

+Joe Kensei As far as I know, hyperlipidaemia contributes to driving the LDL into the intimal layer. LDL is retained via association of ApoB-100 with negatively-charged proteoglycan residues in the ECM.

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@zlkzayas1]

Very helpful!!

[@mohammedBinAli77]

thank you

[@andrewsbaha6569]

thank you so much.it has been helpful....

[@HealthEdSolutions]

You’re welcome. Glad you found it helpful!

[@alaba99]

Cheers andrew

[@pashleyfication]

Thankfully my exam has been a good excuse for staying indoors and studying. I can see the snow on the hills from my window right now :/ It doesn't look too inviting!

[@fradelinoselanno75]

very good lecture, you just taught me the easy way to understand atherosclerosis process. theres no much feedback from me, but you may just speak more clear and louder. because in some part, your voice getting quite, especially when you saying the important point. thank U so much, keep publish more lectures about important topics :)

[@HealthEdSolutions]

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[@abrahameyale4128]

GREAT

[@topraja]

will it be any time soon Sir?

[@HealthEdSolutions]

We will be rolling out new lessons soon. Thanks for watching.

[@drraghie]

thank u...thanks a lottt it ws great explaination...with lots of patience,,,,thumpsup..

[@sabuthomas9262]

thanks. easy to understand even for a lay man.

[@HealthEdSolutions]

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[@شنوتعلمتاليوم]

thank you sir

[@HealthEdSolutions]

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[@benvindamiguel5872]

thank you very much

[@HealthEdSolutions]

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[@mohammedomari1553]

Anderw Wolf its i a great job thnx )) would u make a video about coma , collapse shock thank you

[@HealthEdSolutions]

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[@omarelhassadi2297]

great video than you

[@HealthEdSolutions]

Thank you Omar!

[@sonamdechen1040]

Thankyou , this has helped me so much : D

[@HealthEdSolutions]

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[@rubexcube1457]

amazing thank you ! :)

[@HealthEdSolutions]

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[@TheLordMow]

THANK YOU!!!

[@HealthEdSolutions]

Keep watching, we appreciate the support!

[@poochyboi]

how does diabetes damage the endothelial layer?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@poochyboi]

@@HealthEdSolutions 5 years later and i still don't know how diabetes destroys the endothelial layer. Perhaps I will know in another 5 years.

[@R0V3Rvids]

Thumbs up! :)

[@SaifAli-ex5ey]

Thanks

[@HealthEdSolutions]

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[@fancypanties]

THANK YOUUUUUUUUUUUUU VERY MUCHHHHH!! :>>>>

[@HealthEdSolutions]

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[@benavidus]

i´m from colombia too. this is an academic project, not your business room.