Paul Saladino Talks About The Real Differences Between LDL & HDL Cholesterol

[@sidscarborough3160]

Joe’s studio decoration finally fits the topic. They all sit inside an artery pretending to be lipoproteins. ❤️

[@brittanym2080]

Have you seen this clip of Joe’s guest telling him the new studio is awful?! kzbin.info/www/bejne/l32Vq6OhpbysmKM 😂

[@adamcallaghan2135]

Hahaha

[@jakep1979]

And it smells like a bleeding carcass of elk.

[@shaddowwxy3307]

Hahah well observed!! 👌

[@annibridgett9334]

😂🤣👍🏻

[@Shane-zl9ry]

Joe just eats Elk fried in CBD oil.

[@brittanym2080]

😂 Have you seen this clip of Joe’s guest telling him the new studio is awful?! kzbin.info/www/bejne/l32Vq6OhpbysmKM 😆 it’s hilarious!

[@BrokenAbyss]

@@brittanym2080 why tf is a pretty girl so dedicated to Rogan that she shares links of him, ON HIS CHANNEL?? My guess is you’re a 50 yo creepy dude and you don’t know that poor girl one bit.

[@RanHarasaki]

that sounds pretty good tbh

[@teddymanes9227]

🤣😂🇺🇸🇺🇸🇺🇸

[@aces816]

and drink whisky

[@robiulahmed]

Listening to this dude makes me realise how little I actually know about stuff.

[@manuellopez4151]

You should read Deep nutrition by dr.cate life changer trust me your gonna wanna empty your fridge after reading it

[@robiulahmed]

@@manuellopez4151 thanks for the suggestion. I'll look into it.

[@SenorJuan2023]

Don't feel bad. This doctor doesn't either. He's peddling nonsense.

[@doctaflo]

yeah, this stuff is poorly understood in general. don’t give a couple of confident speakers the last word. there’s always an evidence-based counterpoint (because the studies on cardiopathology contradict each other, and many are of poor quality!)

[@g99se9]

@@SenorJuan2023 he’s young, loud, and healthy. Doesn’t make him correct.

[@tonys4039]

I clicked expecting to disagree with the discussion, based on previous discussions of this content. As a biochemist focusing on lipid metabolism, I'm actually pleasantly surprised. My current studies are likely to demonstrate why high LDL can be indicative of improved immune response, rather than causative, but other than that I'm just shocked that this discussion was so good.

[@nick-dq1hh]

Another random “once you get into the research” person with credentials that deem them as important talking vegetable oil being the cause of issues and not animal fat? Lump that in with the hundreds of books written by saggy old doctors telling you what they believe is true. And then you get the other crowd that says “starch/carbs” are the issue while they mean overconsumption of sugar, not just “carbs.” If you do actually “get into the research” dose, storage, use (frying, cold pressed oil), all matter. Animal oils don’t suddenly get a tag of “half monounsaturated and half saturated” with the addition of “so it doesn’t make sense why saturated fats are being blamed.” Both of those exist exclusive of each other...because dose means everything. Just as coconut oil shows some possible negative effects on cholesterol because of the saturated fat dose. Also, the matrix of the food influences the ultimate outcomes in the body. Choosing a few bare vegetable oils that happen to be worse for you (let’s say soy oil and canola as basics) and saying that all vegetable oils are more to blame is basic surface knowledge on nutritional science that’s spread by people who say “if you get into the research.” Follow the research yourself, not what some guy tells you to look at because he’s cherry picking, and be open-minded. People like this muddy the waters. And ultimately they are in the wrong side of this. Because they give one side leeway and blame another, when it’s all to blame in different contexts.

[@cnmg7121]

Hi, I'd love to read your paper in this regard. Any reference available?

[@BOZ_11]

where's your paper pseudo boy?

[@JoeyNTasha]

Did you go to Regis University?

[@JoeyNTasha]

@@BOZ_11 where did he say he had a paper? 😆 he said his studies and also said "are likely to demonstrate" which alludes to his studies not even being complete yet. Also, you come across as a rude child so I highly doubt you could even comprehend such a 'paper' 😆

[@stevejones9717]

This dude is a genius. PLEASE have him on more often!

[@Gimsu]

that happens when you bring a person that is not a professor, he sounds dump, let me explain, what he showed is about the "atherogenic index" - which means if you put HDL and LDL together, what is the index number, if this number is bigger than 5 then you are at risk of artery disease, YOU CANNOT RISE HDL WITH MEDICINE, and cigarettes' and not exercise kills HDL, so to have an index lower than 5 you need to drop your LDL, how can someone not understand that? if you smoke and you are not active, and your HDL is low, your high LDL WILL CAUSE ARTHROSCLEROSIS. now stop crying and eat some plants.

[@nazgul7914]

this dude is now everywhere on youtube shorts.

[@njparady]

He’s not he’s just taken a lot of biology classes.

[@henke3465]

@@njparady doesn't matter if hes taken a lot of classes or not. He's still right and the fact that he can explain this too us average individuals makes him more likeable.

[@ghostshipone]

He’s a salesman

[@kdude7510]

If I never found this guy I wouldn't be in the shape I'm in today. I tried to eat the same foods he does I'm in my 40s and I felt better now than I did in my 20s

[@orthodoxboxing9159]

Im 20 so I’m getting this information at a young age.

[@pole_barn_builder]

Are you pulling poon?

[@bigbadgjn]

Well this could really upset a lot of life insurance companies who have been loading (charging higher percentage of premiums) based on a person’s high cholesterol. A smart lawyer could run a problematic class action against an insurance company

[@larrymoore338]

A majority of Life insurance companies do not charge higher premiums due to high cholesterol. You may be confusing this with high blood pressure. Very common mix up

[@bigbadgjn]

They do charge higher loading on the premium for high cholesterol in Australia

[@iCitizenTube]

@larrymoore338 you are completely wrong. My wife has high cholesterol and after being refused by many expat insurances we found one german company who accepted her with a 18% premium and not covering any illness related to high Cholesterol. Do some research before giving an uneducated opinion.

[@peterfialka5315]

LDL today plays part in insurance policy and for a good reason. Everything this guy said is simply wrong. There is scientific evidence that debunks all. He is just there for a money grab with most other carnivore influencers. They tell you how recommendations are bad for you though no one follows them and if people followed them they’d healthier. They tell you evil pharma blabla and look at them selling supplements without any testing. Pharma pills at least have to be compared with placebo before they get approved. Supplements nope

[@blake6227]

Saladino is who Rogan needs to have on to debate the Vegans. I haven't seen anyone that can just rattle off the science and studies off the top of his head like he can. He knows this stuff inside and out.

[@xridex400]

This may be the first and only time I've had to set a podcast play speed slower

[@cmd1985]

67 seconds into the vid and I'm already lost.

[@bthomas2782]

Have you seen this clip of Joe’s guest telling him the new studio is awful?! kzbin.info/www/bejne/l32Vq6OhpbysmKM

[@gtfourziggy2]

Hes talking about carbon chains in fats.... duh!

[@mike-roberto]

The long story short is that the heart disease crisis didn't begin until everyone started smoking processed cigarettes, and the obesity crisis didn't begin until they told us to stop eating cholesterol and saturated fat and to start eating "vegetable oils". These vegetable oils are really "industrialized processed seed oils" - basically waste oil - high in these unstable, rancid omega-6 fats, and they're the REAL drivers of our health problems. The longer story long: Cholesterol / saturated fat (eg animal fat) = satiety. Combine them with protein like in a steak and you feel FULL. Seed oils (omega-6 fats) = HUNGER. Literally driving the munchies via endocannabinoid activation. When you start eating ancestrally (eg animal foods, some plants, and NO processed carbs or seed oils), your LDL often goes up.This scares people, because it's been weakly associated with heart disease. Note that LDL is the ONE marker that doctors have been able to treat (with statins) without killing you. Statins are insanely profitable but practically useless for the entire population. So if people are getting insanely healthy / shredded / focused with an ancestral diet high in red meat that sometimes raises LDL when they become lean enough, it's driven them to question the "LDL is bad" mantra. And it turns out that if you're eating right, LDL is nearly MEANINGLESS. Triglycerides and HDL are far more important in a lipid panel. So are fasting insulin and HbA1c (blood sugar markers), two things most doctors sadly still don't even measure. I went down this road personally, and with the help of Dave Feldman mentioned in this video, as well as Ivor Cummins, dug up 4 enormous observational studies that showed people living LONGER and BETTER with high LDL - so long as triglycerides were low and HDL were good, just like my blood work showed. You can read it all here: blog.priceplow.com/diet-research/ldl-cholesterol Hit me up with any questions. I have research all over the place on this stuff. Once you realize how bad these seed oils (and the linoleic acid inside) are, it's a shock... because that garbage is EVERYWHERE. -Mike

[@gtfourziggy2]

@@mike-roberto to put it bluntly, from my understanding, plant based oils and fats are bad, animal based oils and fats are good, when combined with HIT exercises...

[@mike-roberto]

@@gtfourziggy2 I mostly agree if you need to keep it super simple. Caveats = pork/chicken that is fed soy and other garbage - they are higher in PUFA and linoleic acid. Grain fed beef is higher in omega-6 too, but not horrible. On the plant side, there are good saturated fats in coconut (I like MCT), and cocoa butter (stearic acid = SATIETY), and you can get decent omega-3s in the form of ALA (but not DHA!) from walnuts, chia, and hemp. Might have to grind the chia down. There's probably a few others, but most other plant fats are garbage. I'm a bit less on the monounsaturated fat train than most health advocates out there, personally. Saturated + omega-3 for me.

[@Zulethe992]

Not sure what this video is about but after watching it I’ve lost 100 lbs, I’m no longer diabetic and my anxiety and depression are gone. I also sleep like a baby and recently got a promotion at my job. All because of this video!!

[@shane6284]

I do a 20 hour fast 3 times per week and just found out that my total cholesterol and LDL was “high”. This video was so timely and eye opening.

[@trevbarlow9719]

Careful with this guy's advice, though.

[@shane6284]

@@trevbarlow9719 That could be said for anyone including certain medical doctors. Especially in this day and age.

[@trevbarlow9719]

@@shane6284 I mean, this guy has recently flip-flopped, it seems. He appears to now advocate eating some plants and even rice.

[@shane6284]

@@trevbarlow9719 I can totally see the benefits of the carnivore diet if you have serious chronic illness, but really.. how sustainable is that diet? Eventually you are going to want to add different foods, and see how well they digest. A “diet” should be an evolutionary process for each individual.

[@ChonchoLibre]

@@trevbarlow9719 His views over the past couple of years have stayed mostly the same, only changing his perspective on the inclusion of fruit and honey into the diet. It's more about being open to new information rather than flip flopping. If he held his opinion 100% the same over the years, that would only prove close mindedness.

[@davidfunk3505]

Very interesting stuff! I used to be humongous, 350lbs. Type 2 diabetic. Hypertension. Hypotriglyceridemia, and as a result would get pancreatitis all the time. And a lot of what this guy is talking about sounds related to what my body was going through. Still diabetic but I lost a lot of the weight, and not getting pancreatitis like I used to. I'm very intrigued in what this guy is looking at, hopefully learn ways to fine tune my diet to work better, and keep me out of hospitals.

[@johnnycordova5939]

I very strongly recommend that you get a copy of Dr. Jason Fung's The Diabetes Code. It'll change your life.

[@IvySnowFillyVideos]

My dog had pancreatitis...it's painful😿. So sorry to hear u have this...but great to hear about the positive changes u made❤

[@ontheblocknba]

How are u doing now

[@Stamnessj]

Just reading through comments and found yours 1 year after you made it. Any update on how the last year has been?

[@tscmph]

have you tried a temporary keto diet?

[@kentgrady9226]

Two years ago, I had an anxiety attack that I thought was a heart attack. I checked in to the hospital, where they calmed me down, checked me out, and gave me a clean bill of health. BP, 112/72; resting heart rate, 54 BPM; cholesterol, 158 with optimum levels of HDL and LDL. Eleven months ago, I had, and obviously survived, a widowmaker heart attack - 99+% blockage of the Left Anterior Descending artery. They told me that the most likely explanation is what they called a plaque blister. Tissue covers build up of plaque, then ruptures, sending it downstream where it eventually gathers and creates a complete or near complete blockage. There are perfectly healthy people with 35% blockages. But, if that plaque dislodges and gathers at an artery bend, the result is, well, bad. Having experienced both an anxiety attack and a real heart attack, I now know the difference. They're nothing whatsoever alike.

[@aidancoll919]

can you explain the differences? and this is fucked up but naming a heart attack, "widowmaker" is fuckin hilarious

[@kentgrady9226]

@@aidancoll919 An anxiety attack is just that - elevated respiration and heart rate due to an adrenaline overload. Certain people are especially prone to them. I am amongst them. The lead up to the heart attack was quite strange. It started with tingling in the extremities - like a tourniquet had been applied to all four limbs. I felt light headed and dizzy (decreased blood supply to brain). I had the pain in my left arm. It was a dull ache, almost like a case of decompression pain like scuba divers can get from ascending too rapidly. Cold sweats like I'd never experienced. They were instant and *ice* cold. Nausea, vomiting. They call that specific type of heart attack the widowmaker because the survival rate is very low. You've got better odds with a gunshot wound to the chest.

[@JamesSmith-cm7sg]

What's was your diet and exercise like before the heart attack? How old are you?

[@kentgrady9226]

@@JamesSmith-cm7sg Diet was probably not optimal, but far from a disaster. I do eat (and did, at the time) fruits and vegetables. I don't go nuts on sweets or fast food. That said, there was a lot of room for improvement. I'm not the gym rat I was as a young man. But my job (construction project manager) required a lot of walking, stair climbing, etc. Step counter always indicated ~ 15,000 paces per day, minimum. I'm no magazine cover model, but I'm not fat, either. (6'1", 215 lbs - probably should weigh about 200). I was three days shy of my 49th birthday the day of my heart attack. I'll be 50 next month. Are you physician or medical professional of some sort?

[@Ringwraath]

Glad you made it through Kent. Sounds like you are doing better now and best of wishes to your future health. Edit: as a medical student it is interesting to see all these questions about your health. Don’t get too caught up in it and just lead the best “healthy” lifestyle that you can :)

[@michaelbrutallyhonest6026]

This dude's using a much higher % of his brain than I am. It's extremely interesting, a bit intimidating, yet very motivating.

[@roaldruss4211]

I suggest you double-check what he said. You'll find that all clinical studies (look for randomized control groups) contradict his claims. Don't take ANYTHING at face value!

[@michaelbrutallyhonest6026]

@@roaldruss4211 would you please link me to one clinical trial study conducted on metabolically fit people showing that their high LDL and HDL levels together are contributing to heart disease?

[@benitocamela174]

@@michaelbrutallyhonest6026 nah, this dude is a quack, look at layne Norton's debunk of the entire podcast, he has also been a guest on Joe rogan btw

[@rodneyodell8959]

www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/

[@rodneyodell8959]

@@roaldruss4211 double checked, it checks out www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/

[@pablov4]

what medical school says to this: fat and fatty molecules, like cholesterol, cannot just be in the blood as they are, they need to be put in lipoprotein vesicles. LDL: low density lipoprotein, is formed in the liver (which is like the center of metabolism) to provide cholesterol and fat for the cells in your body. the cells in your body have receptors to receive these necessary molecules. but if they don't need more, they will stop building those receptors. so the LDL will stay in the blood. and at some point it will alter the blood flow and chemical homeostasis so much that there will be more inflammatory and thrombotic events in your vascular system. this means higher risk of stroke, heart attack and so on. HDL: high density lipoprotein, is formed by the cells, to bring cholesterol and fats they don't need to the liver. high LDL and low HDL: the LDL is stuck in your vascular system. high LDL and high HDL: higher metabolism, so more LDL is actually used in the cells, as part of a working metabolism. it is not "stuck", but just transported more often at the same time.

[@timestreak3715]

These people fighting over meat or vegetables. Oh man tell them what is the deffination of diet: Eating right amount of every type of food!!! So simple, the point is people are not eating enough vegetables and taking in too much meat! We have to get benifits from everything and there are side effects of eating too little or too much meat, vegetables, carbs and etc...

[@BoyBlessing]

@@timestreak3715 wrong

[@timestreak3715]

@@BoyBlessing i dont mind criticism, but this is my first time commenting on this channel, by seeing how they mix vegetables with wild plants. Moreover, he would probably the only guest i might hate on this channel

[@lalithrockz]

@vDnknDounuts -_- seems like they are arguing that low hdl is the prob not high ldl.

[@pablov4]

@@lalithrockz no, medical school says LDL is the problem. But if you also have high HDL, then maybe it is not a problem and your body can deal with more LDL.

[@Dana-op6ex]

I started IF, very low carb, good fats, all organic and my LDL went up 115 points, triglycerides went back down (lost 10 pounds) from 60 to my normal 26. Since that last blood work, I've gone Carnivore. My physician is worried, stumped and I feel great. Thanks guys!

[@chriss4084]

Hes just worried he cant sell ya pills

[@shrutefarms4741]

This discussion is an excellent presentation of my experience. I lost 80pds on keto. Have kept it off for years eating mostly protein and fats. My LDL jumped way up but so did my HDL. I’m very lean and have never felt better but my doc put me on a statin. It balanced my cholesterol out but now I’m concerned that I maybe shouldn’t take the statin. So frustrating to feel absolutely awesome and be told my numbers are frightening.

[@aces816]

you should read the great cholestrol myth. people mistake LDL for bad cholestrol. LDL is in your heart artery because your artery is damage in first place. LDL function for repair your artery. jsut read that book its open up your perspective of Fat

[@CelineNoyce]

I have high cholesterol. My doctor was going to walk unless I got on statins... I told her no... but I would get a Coronary Artery scan... results (age 50) ZERO! Get a CAC. Also, it is well known that reducing blood viscosity reduces the risk of clogged arteries. There are studies showing that donating blood reduces your risk of heart attack by 80% and premenopausal women, who donate blood every 30 days anyway, are unheard of as having artery build up before menopause... it is because their blood viscosity is lowered by losing blood.

[@shrutefarms4741]

@@CelineNoyce wow good to know and look into👍

[@adamletschin7759]

Your doctor does not understand, he is just being fed info from big pharma.. Statins are useless

[@YouTuber-ep5xx]

Spend $100 on a CT scan of your heart that will show if you've plaque in your arteries. Plaque calcifies and the calcium show up on CT scan. The scan will produce are CAC - coronary artery calcium score - that will tell you how much blockage/plaque you have. If your score is low, like 0, I would no way take statins. The radiation of scan isn't much - comparable to mammogram. If the score is high, I still wouldn't take statins, I'd go low carb and get metabolically well. In any case, statins aren't worth taking, don't improve mortality rate or buy at best just a few more days on average.

[@lemongavine]

Blood tests are typically done after fasting. If LDL rises while fasting, wouldn’t that make your LDL appear artificially high?

[@darlae88]

I think he means someone who fasts regularly, maybe prolonged fasts. I don’t think a 12-14 hr fast is long enough to significantly change it.

[@championsintraining4456]

Joe you have to get Dave Feldman on! I’m a Strength Coach and have been following him for a couple years and fit the lean mass hyper responder model. Dave deserves to be in main stream conversation. His work will destroy all the bad nutrition messaging from the 60’s such as food pyramid, cholesterol, insulin, diabetes treatment, etc... Time to shake up the world!

[@Travisg5]

Paul has saved my life I’m very grateful for his knowledge

[@ameyabajaj1590]

How

[@PolPotsPieHole]

@@ameyabajaj1590 too say it in as few words....Seed oils and processed sugar are poison and Kale is Bullshit

[@Travisg5]

Got my health back can run and play with my kids can breathe again lost hundred pounds I sleep so much better my pains are gone

[@byEnTaze]

Here are the lyrics for my new song called "Why do we have cardiovascular disease": SUGAR SUGAR SUGAR SUGAR, SUGAR SUGAR! SUGAR SUGER SUGAR. SUGAR SUGAR SUGAR SUGAR. SUGAR!!! What do you think? Give me your honest opinion, I value your constructive critisism.

[@williammillerjr9028]

Sweet...

[@MariaPerez-uv8mm]

This was really funny! Thank you :-)

[@a3300000]

You are 100% correct.

[@annmarie3573]

Sugar, seed oil, empty carbs (which are basically also sugar in the body)

[@MP-tj5xv]

You rock!

[@tylerferrell2959]

Joe Rogan is just sitting there like “man I should not have had that edible “

[@shaskins15]

He definitely did lol

[@oscarcastellanos9270]

I'll never get why people glorify weed, it's kina sad.

[@ryanp6999]

@@oscarcastellanos9270 there's a lot of things in life that we'll never understand.

[@AkiraHDR50]

I just read this at 5:40 and PMSL.

[@howaboutsomesoyfood]

@@oscarcastellanos9270 better than glorifying alcohol.

[@d1n0_mb]

That's why my LDL was higher than normal when I did my blood work. I was fasting for more than 36 hours at the time my blood was extracted.

[@RyanHicks]

I was thinking the same thing when i was watching this but with my blood test this year it was down much more with the same fasting timeframe... so?

[@d1n0_mb]

@@RyanHicks people are different.

[@bluceree7312]

Yeah. Earlier this summer my LDL was a bit high, HDL was high too so not too much of a problem like explained in the video. Nevertheless I started to work out in the summer and lost weight and I could feel the fat shedding away in the summer. LDL test last week was up! WTF? my BMI is 23.5 which is great for my age and hight and I feel lighter, with less visible fat but my LDL is higher? why? I usually don't eat after 8pm so on the day of the test I hadn't eaten for 12 hours. it is not fasting per se, but it kinda is. I do not feel unhealthy and I am young and lean like Paul says so I don't think there is a problem. everyone is different.

[@YouTuber-ep5xx]

@@bluceree7312 Perhaps you are what Dave Feldman calls a Lean Mass Hyperresponder. Check him out on YT.

[@RolyTheHolyPaladin]

@@bluceree7312 Too much Zinc?

[@rosea2350]

I have a heart condition and my cardiologist said my cholesterol was too high and put me on medicine that made me have chest pains. My cholesterol was improving with exercise and diet but that wasn’t good enough for him, I do not trust doctors who push pills.

[@iLeanonsyrup]

Did you start taking fish oil too?

[@sunnysideup5826]

High cholesterol levels is a mechanism in which your body is trying to heal something (cells are made up of cholesterol). Don't kill the high number of firemen during forrest fires, kill the fire

[@DeOCee]

@@sunnysideup5826 That's a great analogy. I'm going to use it for my Patients

[@sunnysideup5826]

@@DeOCee the credit goes to Dr. John Bergman for that analogy, my good sir

[@jodyjackson5475]

@@sunnysideup5826 he’s awesome 👌🏼

[@jenniferlee2346]

All these comments of people who can't keep up. I felt like that too at first with Dr. Saladino.. but then I kept listening and listening and hearing similar things from other doctors and now he makes more sense, even with the medical jargon. It takes effort to dig into this stuff.. there is a LOT. I am appreciative that Dr. Saladino can speak on the same wavelength as other medical professionals so they can grasp what is going on because they are the ones currently handling most people's health. If you don't understand wtf he's saying then break it down and figure it out. You won't regret it.

[@brettf2]

He's bringing up syndromes and studies where LDL was absurdly low or absent. LDL may have been over demonized by the media, but his examples don't prove a point. -"Why would the body make something that was bad for you." Non-scientific statement -"Extremely low LDL is bad." That doesn't mean high LDL is good.

[@zebra7462]

The body can make a lot of things that are bad for you, like cancerous cells.

[@chriskent8698]

The body producing more LDL means there’s more nutrients to transport around the body. The problem is when it gets oxidized by excessive glucose and can’t be absorbed by the liver. At that point, it can get lodged in the artery walls, and plaque builds up around it.

[@jenniferlee2346]

I am glad you did a clip that breaks out this part! Important information here. ❤ The whole talk was awesome, but this is such a huge question for people in my life and in general, it is nice to have this to share. Thank you!

[@14moon85]

I share your thoughts and feelings I am glad they did this also my doctor want's to put me on statins and I'm in really good shape and condition had all my cardio work done and checked my arteries and everything recently no problems just have hi cholesterol and they want to put me on statins I'm not overweight by no means and this pretty much solves it for me I'm not going on statins ..... Very informative show Joe thank you....

[@mighty_wolf]

So high cholesterol diet does raise LDL, but as long as you're healthy with good insulin sensitivity and a high HDL, you will be perfectly fine.

[@kjmalone17]

Nailed it. Pre fasting my HDL was 28, triglycerides 215 and not sure on my LDL. Now 50lbs lighter mainly carnivore with fasting HDL 73, Triglycerides 73 and LDL 167. Dr would put me on meds for the LDL alone but I expect my ldl to be on the high side. Have perfect triglycerides to HDL of 1:1 and my VLDL they want from 10-40 was 52 and now 12.

[@GardenGuy1942]

Yes - HDL is a negative risk factor (more is better) and LDL is a positive risk factor (more is bad). Having higher LDL with other comorbities (HTN, DM, Smoking) will make your health much worse. (ie obese smoker with COVID more likely to die than athlete with COVID)

[@Gengh13]

If you eat saturated fat your LDL increases, that doesn't mean there is anything wrong with it.

[@JM-961]

consuming foods high in cholesterol specifically (i.e. eggs) has never been proven to increase your cholesterol levels so don't have to worry about that. Eating foods high in fat increases your cholesterol. What this guy is saying is that having high blood lipids (LDL) alone might not actually be bad for you, it's really interesting stuff. Particularly his point on fasting makes a lot of sense; burning more fat requires transport of the fat throughout the body during fasting, which is the function of cholesterol. High Blood Pressure is a way bigger deal IMO.

[@miguelespejel2462]

Nah it doesn't been eating nothing but meat eggs and sea food and my ldl is 104

[@apm9507]

Closer you can get to eating backyard garden vegetables, ducks, chickens and maybe goat the better. Slow cooker stews with backyard food is good too IMO.

[@blacksheepnomad9000]

@@funart6210 stop posting this on all the comments we get it

[@makatron]

@@blacksheepnomad9000 yeah just spamming the comments lol

[@blacksheepnomad9000]

@Arnold Crentist not angry just looking through the comments and I see this on around 12 of them so my one comment calling them out is angry? Oh and look it's gone because KZbin decided they were spamming? Why are you so angry?

[@blacksheepnomad9000]

@silviu visan my comment wasn't to the OP It was to somebody spamming on all the comments

[@shaneshane9419]

Less bird and more red meat

[@ohheyhowyoudoin9635]

I've been trying to teach myself real health, diet, nutrition, and the more I look into it the more it seems that too much insulin is one of the worst culprits in terms of bad health.

[@mohameda5325]

And too much linoleic acid (omega 6) from seed oils is very damaging too

[@wolfhawk1999]

Glad I saw this video and similar videos. I'm down 45 pounds with low carb and fasting (18-19 hours a day). I recently got blood work (I was about 16 hours or so into a fast when I got it done) and my LDL came back as high. My HDL is normal. If anything, I was having chest pain before I lost the weight. They recommended I eat egg whites and more carbs. Not going to do that.

[@fortyozsteak]

Fruits, honey, and sweet potatoes are good sources of carbs. You’ll feel better with higher carb over the long term just ask Saladino who now eats 250+ g of carbs per day after being keto…

[@MrJtin69]

@@fortyozsteak facts also helps bowel movements

[@billdublewhopper3064]

@@fortyozsteak he probably was laying down plaque and calcium.

[@billdublewhopper3064]

@Henk CAC only detects calcified plaque. Not un calcified plaques

[@TheSkala9]

Funny how it works for each human, this guy is completely against fasting

[@divobravo3133]

I’m living proof that what you are saying is totally correct. Never been healthier eating low carbs, higher fat diet. Goodbye insulin resistance.

[@emptysea1137]

seems to be a very impressive discussion between two very well informed people. impressed.👍

[@mikybinns9343]

Been following this guy for a while, he knows a lot, very intense, passionate and talks fast. Like most complex issues, we need a threshold of knowledge to understand this. Stick with it people this will be the new paradigm

[@SenorJuan2023]

He's a total quack. Trying to make a mint selling his book.

[@alansherwood5319]

@@SenorJuan2023 which nutritionist do you trust the most?

[@99.99]

He backs it with zero study. They're all bs. All of them.

[@uselessvideo]

@@SenorJuan2023 U just gonna leave it at that a year later, or u gonna bless us with counter-evidence for his "quackishness"?

[@SenorJuan2023]

@@uselessvideo All you have to do is read The Blue Zones to discover how many lies Saladino tells about it.

[@keithcampbell7820]

So for 50+ years of having at least a cursory understanding of medical terms, procedures and theory, I’ve bought into the cholesterol bs. Thank you very much for shirking the common narrative and bring this out. My uneducated self saw more logical and rational thought in 16 minutes than those 50+ years.

[@airmark02]

Not to mention the use of Sun Screens & AntiDepressants & on & on & on ...😏

[@keithcampbell7820]

@@airmark02 , actually not. I’ve shirked sunscreens as I grew up in the public pool arena in the 60’s and 70’s. Antidepressants in different forms than prescribed along with nutritional supplements that made sense. Now, low carb, no scripts and thc still rules

[@dkinblu]

Docs having been trying to get me to take statins for 28 years, No way, the cholesterol numbers are a big Pharma scam.

[@lpg12338]

If I was a person who was concerned about my overall health, I would get a full blood work up done. Also, I would look at the following test, Coronary Artery Calcium (CAC) Scoring, carotid intima-media thickness test (CIMT), ankle brachial index test, and an oral glucose tolerance test (OGTT). The primary goal, is to reduce stress and blood pressure and glucose. You MUST protect the endothelium tissue.

[@StriderGTS]

Saladino has a LDL of 533 the last I heard (not mentioned in this video) but has a calcium heart score of ZERO. His LDL is also the good big fluffy kind, not the bad small kind. LDL doesn't matter unless you are metabolically unhealthy.

[@Steve-gj3gf]

2019 calcium heart score zero......keto diet for 2 yrs.......2021 calcium heart score still zero. Slightly elevated LDL.......want me to take statons . No thanks.

[@StriderGTS]

@@Steve-gj3gf exactly!

[@heavenlymonkey]

@@Steve-gj3gf 😂 (they probably want you to take a bunch of other expensive medication as well)

[@alansherwood5319]

@@Steve-gj3gf do you think it’s worth getting a heart scan every couple years despite the radiation?

[@alansherwood5319]

How do you know if you are metabolically unhealthy?

[@jerryl5895]

When I was in my 20s I could care less about cholesterol. Now I'm in my 30s I feel like I'm dying everyday!!

[@stacielivinthedream8510]

Why would you feel like you're dying everyday? Stop listening to the sick care system unless you're cholesterol is 500 and above you shouldn't have to worry

[@fredosantanasalinas7826]

Yeah basically the healthcare system sucks and is full of false information and is just trying to make money off people by feeding them false information so that their fear makes them buy into prescriptions which 99% of the time makes everything worse

[@youtubemoderationtaskforce5583]

You could feel like you’re dying because you spent too much money on those wheels on your truck instead of eating a healthy diet.

[@jerryl5895]

@@youtubemoderationtaskforce5583 lmao I don't even have that truck anymore!! I got a newer truck with a 6k lift!! It was just a figure of speech how we don't think about health till we are in our 30s or 40s.

[@youtubemoderationtaskforce5583]

@@jerryl5895 I understand the figure of speech but I bet there’s at least some truth to what I said about your truck. 6 thousand? Damn dude. I’m working on my truck right now and I’m trying to spend less than 800 with new spindles, bed, paint job, windshield, seat, exhaust system, bumper, etc. It’s a 2001 s10 though. All I had to do was buy another decent s10 with a good body and crap motor and take parts off of it, then buy paint online and do body work and paint it myself.

[@Under_Growth]

I love it when guests take the liberty to tell jamie what to do

[@jayfinn6698]

I'm 56 ,triple bypass 2 year's ago worked out bodybuilder like 25 year's but had a bad diet, now no grains intermittent fasting every day basically omad. LDL-156,HDL-84,Triglycerides-56. I FEEL GREAT.

[@SeahawkAz]

your HDL/Triglyceride ratio is excellent, great job

[@jayfinn6698]

@@SeahawkAz Thank's John, research is important! by the way i take ZERO PILL'S.

[@deele7991]

Just curious, did you have a heart attack? I'm about your age, and had a pretty bad calcium score. #'s are similar to yours. Wondering when I'll need stents or a bypass.

[@jayfinn6698]

@@deele7991 I did David unfortunately ,cut grains and carbs eat fat and stick to it .God's speed my friend.

[@SeahawkAz]

@@deele7991 supplement K2 to decrease the calcium in your arteries

[@blacksheepnomad9000]

For the people concerned about this guest choice of vocabulary if you don't understand it I'd recommend going and watching a few nutrition videos explaining the subject then coming back not just dismissing him because Your knowledge is lacking. Most of the terms he's used are actually pretty basic

[@blacksheepnomad9000]

@@Tatertodd007 I totally agree I'm more of talking about how people are dismissing him just because he's talking in a vernacular they cannot understand

[@blacksheepnomad9000]

@xannyphantom yeah he's biased as hell. I believe in eating a good amount of animal protein but I also believe in eating in vegetables as well. Lettuce was first cultivated by the Egyptians It started as a weed and we have crafted it to fit our biome as best as we can. He's dismissing that part. yeah a lot of plants don't evolutionarily match up with us but we as humans have made plants match up with us through trial and error

[@blacksheepnomad9000]

I watched the whole podcast as well I'm more of commenting on his remarks on cholesterol. I eat four eggs a day and a few portions of meat as well. which of you could imagine is a good amount of cholesterol usually over a thousand milligrams a day. I get blood tests once a month though and my blood cholesterol levels are always good. I'm also a server so I walk probably 5 plus miles a day and I work out for 2 hours a day.

[@beoptimal8650]

@@TheNaturalHealthBlogger It's definitely not complete pseudoscience :) Get more involved in the work of Dave Feldman and you might think otherwise!

[@sportysbusiness]

@@TheNaturalHealthBlogger Wrong! There is no evidence LDL causes athroscrolosis, quite the opposite. The study you site is a great example of 'double speak'. A report that states 2 things that contradict themselves at the same time: 1. LDL is unequivocally recognized as the principal driving force in the development of ASCVD 2. The pathophysiological and genetic components of ASCVD are not fully understood. Read this study, for example, that shows low levels of LDL correspond to INCREASED mortality. There is so much we don't understand, but blaming our natural hunter gatherer diet that we've eaten for hundreds of thousands of years for a disease that's only been around for the last 50 years is BS. What have we done in the last 50 years, eaten more processed carbs and vegetable oils and LESS saturated fat and red meat. We're blaming the wrong thing. www.ncbi.nlm.nih.gov/pmc/articles/PMC6832139/

[@mryorkielover]

So basically, we dont know what the difference is........

[@GardenGuy1942]

We know that LDL is a positive risk factor (more is bad), and HDL is a negative risk factor (more is better) - key word here being *risk*. Both are necessary for metabolic function, and monitoring your LDL/HDL levels are important. What we don’t know is definitive pathology of atherosclerosis (endothelial damage is current scientific thought). So it doesn’t mean that LDL is necessarily bad, just that having LDL with other conditions is bad.. (ie being an obese smoker getting COVID is more likely to die than an athlete getting COVID).

[@TehMadCow]

Well, the key difference is their densities, it’s in the name HDL = “high-density lipoprotein” & LDL = “low-density lipoprotein” lol. This guy talks suspiciously fast & uses terms/language that would be pretty confusing to someone who isn’t already fairly educated on the subject (although I did like his bus analogy). I could only follow because I’m a biology major & recently took a physiology course. This guy is not changing the international medical/scientific community’s opinion just because he manipulated some pre-existing data to make a new graph, scientists already know there’s a chance we might be wrong about something but will always go with whatever shows the strongest evidence...& in this case the evidence mostly shows that high LDL levels can potentially lead to heart problems (especially in males) but there’s other contributing factors like genetics & sedentary lifestyle that contribute to the health risks more than just diet alone.

[@GardenGuy1942]

@@TehMadCow yeah, and more specifically the endothelial damage hypothesis is gaining more and more traction. Fats/cholesterol are a normal thing in the blood, and we normally have like a 4:1 ratio of LDL to HDL. Getting more specific, atherosclerosis is now being argued to be more of a chronic inflammatory disease than anything else. Cell bio of it is pretty wild. The guy does talk super fast tho, I was only able to keep up bc I’m in med school & been doing research on atherosclerosis for the past few months. It was refreshing to have a guest on that was scientifically literate but I can totally see why majority of JRE fan base is thrown off (bc normally Joe would be able to re-package explanations from guests).

[@miguelespejel2462]

@@TehMadCow how do we measure something that can "potentially" happen? There is no mechanistic evidence of how ldl cause heart disease. All we have is epidemiology studies which show a weak correlation (lots of noice) and based on survey data and average people in other words unhealthy people

[@GardenGuy1942]

@@miguelespejel2462 We actually do have mechanistic evidence, not sure if your knowledge is only based off of video but if you’d like a deeper explanation: when the endothelial wall is damaged due to sheer stress and/or toxins, LDL is able to deposit in tunica lamina, initiating macrophages to enter from blood stream for phagocytosis. Essentially, the LDL is eaten up by cells in our immune system until they become so full that they burst, the LDL becomes oxidized by ROS, and all the oxidized fat & necrotic contents trigger more signaling (calcium for example) and more immune responses. Smooth muscle cells in tunica intima and media proliferate. All of that dead “junk” can eventually build up so much that it can either occlude arteries to decrease perfusion or the already damaged epithelial wall can form a fisher exposing thrombotic contents to blood, platelets try to clot it, but because there’s so much pressure the clot can break off and clog up an artery (this is commonly the cause of strokes & “heart attacks”). If you’d like peer-reviewed articles I can send you some PDFs.

[@AkiraSumida]

Dr. Sapolsky covers this in his book (which Joe still seems to never have read along with most of his amazing work...) "Why Zebras Don't Get Ulcers". One short answer is it matters less about hdl/ldl content as mentioned and more to do with the impact of stress (especially chronic). Stress contributes to damaging the arteries, which causes rips and tears along with development of scar tissue (basically less flexible veins = harder to pump/more pressure). Plaque accumulates in pockets and cavities created from damage and can run risk of releasing and causing stroke/aneurism (especially with the increased pressure/stressed if veins have scar tissue).

[@IvySnowFillyVideos]

I think Zebras could get ulcers

[@Pandapowrr]

Just looking through the comments to soak up this information from all these internet doctors

[@ninawildr4207]

Lol

[@SenorJuan2023]

I've read and seen a lot evidence that confirms this Doctor is an idiot. He's about to have a heart attack or stroke with LDL that high and he's too stupid to be concerned. WTF?

[@crisbowman]

@@SenorJuan2023 What happens if he doesn't

[@SenorJuan2023]

@@crisbowman It would be a miracle.

[@mystttu1795]

@@SenorJuan2023 that’s why there’s so many cases of people on a carnivore diet dying of heart attacks? please don’t just research negative things about paul saladino. he know his facts and he is happy to debate it with anyone. you say he is about to have a heart attack but he’s been on this diet for years and is still looking as healthy as ever. for example, i know plenty of people on a vegan diet who are feeling great for a couple months then go down a very big downward spiral into a living zombie

[@robsrave8156]

Dr. Paul is saving lives. Glad I can follow his teachings. It’s awesome Joe is on board.

[@edsiceloff9473]

I like the concept of "fasting causes more ldl". Eight hours of fasting clears the liver, basically, of glucose and we start to burn fat. So, ldl carries the fat to everywhere (mitochondria) to burn it. What I do not understand is that in taking a blood test, you are told to fast. My highest ldl thus far is after fasting for, if I remember, 20 hours. Supposed to be 12. So even with what the drs. prescribe in terms of fast before test, you get an elevated ldl level. It is not your normal everyday level of cholesterol. And they usually want it to be below 100. I can't understand why they want you to shortchange yourself of energy, especially at a point at which you are aging. But, for the purposes given, the test would be invalid as well.

[@capshorts00]

id assume that if cholesterol is raised, the fasted state would still be higher than a normal persons fasted state and look much more apparent

[@redledbetter1]

I thought this exactly as well. My guess is that they administers are trying to present as best a level playing field as possible. Variations in these numbers will occur naturally because of recent diet up to the testing. If the normal person obstains from causing these fluctuations, however minor, by fasting as everyone else has, they have a better comparison to draw. This however doesn’t take into account fluctuations from other stimuli outside of that brief fast such as the guy in this comment section that said his ldl’s were high but he had just finished fasting for Ramadan. I believe his whole point was this discrepancy, in that ldls aren’t equally harmful or indicative of heart disease when compared in someone of low metabolic health and someone of higher metabolic health.

[@asherasator]

Because the whole medical $ystem with it's priest$, prie$te$$e$ and acolyte$ are trained to bait you in, and take you down the medical rabbit hole and iatrogenic merry-go-round with reliance of their drug$ and service$. It is all deliberate from some level taught down [whether MDs realize it or not], then political social, media, academia psyop and pressure are put upon society to have faith in the them, which maintains the charade and keeps the profit$ going.

[@DeepDiveDetective]

Imagine understanding every word this man says

[@KatherineWhoKnows-ni4nq]

THANK YOU! This is my favorite KZbin JRE clip ever! Great detailed explanation and reasoning.

[@SunShine-kd6td]

It's sugar. That's the 3rd variable. I'm type 2 diabetic and my LDL is high and my HDL is low. I'm not overweight and I fast 15 hrs every day (last meal by 8pm, eat brunch at 11am). Uric acid is high in my urine.

[@TomWolfDrum]

Damn. Get this dude back on here!

[@esch4920]

This dude is a grifter... talks out of his ass.

[@jimmyaguirre4661]

@@esch4920 false

[@mockcosine4479]

@@esch4920 You ought to look at the meaning of grifter.

[@StriderGTS]

He's amazing! I can't get enough of his podcasts.

[@jodyjackson5475]

His podcasts are ah mazing too. So much good content and info from carnivore MD

[@Innate75]

Translation plus a little more: High HDL is associated with good metabolic function and decreased cardiovascular risk, even with elevated LDL. High LDL with low HDL is associated with metabolic disfuncition such as Diabetes, or insulin resistance, and increased risk of cardiovascular disease. Increased LDL alone is not a good measure of cardiovascular disease, a better one is elevated triglycerides. Other very important factors in cardiovascular disease are inflammation or injury of the endothelial wall by things such as hypertension, glycation, oxidated LDL, and LDL particle size, . As far as particle size, the smaller sized are thought to be more atherosclerotic. Finally, different nutrients affect inflammatory/metabolic state in a positive or negative way, inflammatory states most commonly hyperinsulinemia are thought to favor production of small particle LDL. There is more to it, I'm not trying to say these are the only factors.

[@bobbondarul7448]

4 years now carnivore And fasting also I feel great at 43 Exercise almost daily I blame Dr Saladino for this :))) I also have hi ldl and hdl and had a really elevated discussion with my Dr :))

[@alanthompson2753]

Who is unliking an informative video about cholesterol and nutrition ??

[@jaydoe3707]

My cardiologist told me I needed to eat healthier and I ate a keto diet for awhile and my cholesterol went up... He told me not to anymore. How can one say that what you eat doesn't effect your blood levels? Now I'm trying to make sure to walk and workout more regularly along with more vegetables.

[@SaggersAlt]

You'll see how that goes for you.

[@marciaboechat7238]

Dr Paul Saladino wouldn't agree with eating vegetables, though!

[@MJ-yi7ce]

Spotify needs to get a Commentsection!

[@zoecwhelan]

💯

[@lexir7504]

i don't think i've ever heard anyone so full of knowledge lol like the stuff he knows just off his mind is insane

[@jamesfernandes3662]

Thank you Dr Paul Saladino! for your great work and education on health and nutrition! You are changing people's lifes for the better :D we need more people like you asap :D

[@erikvanderveken1408]

He misinterprets the data. Nobody worth their salt is saying LDL is bad. But it is the ApoB lipoprotein that carries ldl part to places you don't want it. Higher ApoB is generally associated with elevated LDL but not always. Some people have high LDL but not high ApoB and vice versa. So, Paul is misrepresenting some of the data. The biggest problem today is not nut and vegetable oils but overconsumption of calories and lack of caloric expenditure. His whole argument falls down because of this because if you look at the data, all the problems of modern times coincide with the introduction of hyper-palatable foods, the biggest problem with these foods is the lack of nutrients (as in micronutrients), and excess of calories. (usually by the combination of sugar and fats). Saying all this started because of vegetable oils is either naive, plain dumb or because he is trying to peddle an agenda (ie: being controversial and getting a lot of views = money because of it), For many people (but not all), going on a diet high in saturated animal fats will lead to higher ApoB, this is well documented in the scientific literature. Not doing anything about it will almost certainly lead to an early death.

[@oanalesnic79]

Keep in mind that this gentleman is a psychiatrist.

[@jamesfernandes3662]

Hey guys and thank you for your replies :) so my question is... what is a proper human diet? 👀🤔 and how do we know that the studies are not published in a certain agenda giving our information and misinforiming us 😬 Dr Anthony chaffeu a medical doctor who is a carnivore and uses it in his clinic said that having a slightly high level of cholesterol is normal and healthy and not actually a bad thing and cholesterol is a big con... so what do we believe? I genuinely believe Paul is trying to help himself and others live a happy healthy affordable lifestyle and thrive, I don't believe he has a hidden agenda... my blood tests have came back all okay and I've been living a carnivore diet for a little while and I feel so much better in all aspects of life.

[@shockmonkey1842]

I believe stress levels are much higher due to fast way of life thus spike levels are much higher than in old days. It may as well be psychosomatic, caused from neurosis, stress, anxiety, etc.

[@collegepennsylvania837]

“The gospel is that I am so sinful that Jesus had to die for me, yet so loved and valued that Jesus was glad to die for me. This leads to deep humility and deep confidence at the same time. I can’t feel superior to anyone, and yet I have nothing to prove to anyone.” - Tim Keller

[@_Epictetus_]

ADL HDL no.... The worst is FBI DEA IRS CIA... If you got any of those you're screwed

[@stacielivinthedream8510]

Lololol

[@stacielivinthedream8510]

I liked your thinking and humor!

[@bashebile1957]

Without fbi,USA will be like south America,no law high crime. But irs that I agree

[@Taureanfitness]

Doctor Saladino made a great point that fasting can raise LDL. I know that to be one hundred percent true also. I've suffered on and off with anorexia for many years & when I am healthier and eat more my LDL goes down, but when I'm fasting or skipping meals. My LDL actually goes up. I think it's the body's natural preservation system to hold onto fat. Feast or Famine mode makes perfect sense.

[@MXF11]

Thanks so much, Joe for asking him beginner questions. I have high LDL and ok HDL. But, I'm healthy af! Bravo

[@kevinclites7641]

Populations that use Keto/carnivore diet (such as epileptics) have been shown to develop arteriosclerosis at an advanced rate. LDL does not directly cause arteriosclerosis, but, it is likely correlated with APO b, which does. I’m a Keto lover, but, recognize that the data is quite clear.

[@27STS]

Sorry but if i follow this guys I'll have heart disease. Ate mostly home cooked meat for a few years, no fast food. Discovered i had very high LDL cholesterol. Now i eat very little meat and my levels went down to a healthy level.

[@AdamKontras]

That's literally what this guy is saying will happen. What you seem to be missing is that high LDL cholesterol is not the issue with heart disease. I know it's a very dense video, but he explains it very well.

[@InvestBetter.]

LDL Cholesterol is not bad for you if your Calcium is under control. Calcium is used to repair damage to arteries, and too much calcium and cholesterol together leads to blockages, heart attacks and strokes. High cholesterol in general is common in people eating Ketogenic, and is not a problem if calcium levels are normal. Vitamin K2 is good for reducing calcium in the blood, and putting it into bones.

[@rodl6759]

Is 10.4 calcium high for a 25 year old?

[@ezdoesit6286]

I've been taking k2 for over a year and my levels are the same as it was without it. 9.7-10.2

[@luxeayt6694]

@@ezdoesit6286 be sure to take k2 mk7 and take enough of it. You could also try taking vitamin D and magnesium.

[@ezdoesit6286]

@@luxeayt6694 I take 5000 d3 with 120 mcg k2 mk7. I also take 200mg magnesium glycinate before bed.

[@luxeayt6694]

@@ezdoesit6286 Try adding 120mcg of k2 mk4 as well and see how you feel. It should be perfectly fine to eat that much as our ancestors are a lot of k2 mk4 as well and the max should be about 300mcg. Also, how much elemental magnesium is in that glycinate? You should check the back of the bottle, be sure you're getting 300mg of actual elemental magnesium a day. This should help increasing your vit D levels as well if that's your goal.

[@AngryAyrab]

This makes sense. I was fasting for Ramadan and did my blood test. My HDL came back as 66 but my LDL was 149.

[@redledbetter1]

That’s interesting. I wonder if it came down after some time after your fast. These snapshots of human health can be extremely misleading when they are not commonly frequently administered. I can see certain responses to my diet on a scale but I might use that 200 times a year. A blood test done every six months may be drastically misconstrued because of temporary causal changes like fasting. I know that my best friend and I were alcoholics for the same number of years. We both signed up for life insurance at the same time and we’re given full physicals. I stopped drinking for three weeks prior and was given a top athlete tier rate. He kept on and was not able to get insurance with that carrier. We drank the same for years but I made a short term change.

[@Taureanfitness]

This is 100% true. I myself personally have high cholesterol. And I have nothing wrong with my heart or audrey's whatsoever. I work for several years for cardiovascular lipid companies. We did advanced lipid testing as well as looked at lifestyle and inflammation markers and genetic markers. There are a lot of factors that go into this and it has little to nothing to do with dietary cholesterol though that can influence it somewhat.

[@TehMadCow]

14:42 The plaque builds up on arteries instead of veins because arteries and veins have different structures/functions! Arteries are a high pressure system with thicker layers of smooth muscle/elastic fiber to help deliver the oxygen-rich blood from the heart to the body parts (think of it like a strong thick somewhat elastic hose). Veins are lower pressure bringing the deoxygenated blood back to the heart, veins have a wider diameter and thinner walls/layers (less smooth muscle) compared to arteries, they’re less elastic too so they are generally more ‘loose’ in comparison, so the blood can pass through more easily. Veins also have valves to hold blood/make sure blood only goes in one direction & veins use surrounding skeletal muscle to help pump the blood towards the heart, as opposed to arteries which have no valves & have smooth muscle in their layers. So basically, because arteries are thicker they have a smaller diameter so it is easier for that to get clogged up over time than veins.

[@SaggersAlt]

Calcification of arteries is one of the primary reasons for heart disease though. So when you make the argument that blood flows smoother in veins than arteries because of them being tougher, it sounds pretty dumb. It's the opposite. The stiffer the walls, the higher risk of atherosclerosis.

[@Onlyhereforashortwhile]

I follow this guy. He’s genius.

[@carloscardo2805]

I am 37 y/o (M), 147 lbs, 5'10.5". Have always been slim; I have a tough time putting on weight. I have averaged 350 miles the last 2 years. In October, my LDL, HDL, Tris, and Glucose came up at 163, 63,118, and 101, respectively. I decided to make some changes to my diet which involved a morning smoothie (Skim milk, peanut butter, oatmeal, a banana, an apple), chicken/turkey for lunch/dinner with either brown rice, quinoa, or sweet potatoes). I reduced my added sugar intake to the point where I have had a hard time coping with the cravings (specially coke). I recently (January) redid my blood work and the results showed improvement: 140 (LDL), 58 (HDL), 72 (Tri), 91 (Glucose). Regardless, my dr. suggested I start taking 10mg lovastatin to bring my LDL down to what she considers normal levels (100 mg/dL). I am clueless in terms of diet as to why my LDL are above normal levels ( I don't eat a lot of processed food, foods with high fat content, or most dairy products); I constantly hear it must be due to genetics. I'm unsure weather I should be taking statins given my numbers. The information out there is overwhelming. I decided to begin but I'm considering stopping after 3 months when get another lab-work again. Suggestions?

[@lenguyenngoc479]

this Paul Saladino dude ditched his carnivore diet already, u should avoid saturated fat to lower ldl I guess👀

[@jasiono87]

@@lenguyenngoc479I think that was more because he wanted to incorporate more fruit into his diet, rather than decrease the amount of saturated fat he was eating

[@asherasator]

Statins interfere with basic Cholesterol liver functions like: make Insulin, Vitamin D, hormones etc. That's how you go further down the medical rabbit hole and iatrogentic merry-go-round with reliance on their drugs and services. But what I noticed in this video is: (1) When he mentions LDL oxidation that's actually why high LDL benefits the immune system. That process acts like a soap and detergent and is antifungal and antimicrobial that cleans through out the body. LDL and glucose levels rise when you fast and part of immunity. (2) His analogy of LDL being a "Full Bus" and HDL as "Empty Bus" is WRONG. There's a cycle and regardless what part of it you jump in on it goes something like this: (A) Cholesterol the liver makes gets shipped out as LDL for your cells etc. (B) The Cholesterol your liver takes in from food raises HDL for Hormones, Vitamin D, Insulin production etc. (C) Sugar and Trans Fats coming in also get converted to Cholesterol and LDL. So "The Bus" is never "Empty". Cholesterol is either "Incoming" to the liver as HDL for conversion, or "Outgoing" as LDL for cellular maintenance. That's why fasting HDL drops because it's not coming in, and LDL rises because the liver is releasing to maintain. (3) Saladino's diet full of animal Fats raises both HDL and LDL. The real trick and key to all this is that when people go "Healthy" they drop or lower foods like: cookies, pastry, baked goods, soda that are full of Sugar and Saturated-Trans Fats that feed into the Fatty Acid cycle mentioned above and get converted to useful Cholesterol. Their new "Healthy" choices are actually not supplementing enough the position of the previous Sugar and Fats from "bad" sources, then you or he didn't feel right. So what Saladino did is he went from a raw Vegan diet which could not give enough basic nutrients, to an animal based one with Sugar/Fructose and Fat levels that work for him. His eating of fruits, organs and flesh is just doing what cookies, pastry, baked goods, soda and "Comfort Food" does by raising Glucose and Essential Fats. It's not about the Protein, whether from vegetable or animal sources, because too much Protein also becomes Fat. It's about Sugar, Cholesterol and Saturated-Trans Fats. That's why it's called "Comfort Food". (4) So whole point is yes you can achieve health by: (A) balanced "Comfort Food" diet with proper proportions and calories which is easier to supply and maintain, whether Vegetarian [not Vegan] or animal flesh based with fruits, vegetables and eat plenty of common baked goods, pastries, soda etc.... or (B) some type of "Caveman" fruit, organ and flesh based diet that is gonna be harder for children and an entire family to maintain, either by food choices and amounts necessary, or simply the cost since Saladino's overlooked preference is "Organic" and "Grass Fed".

[@LavenderSkyla]

I lost 86lbs on carnivore. About 2 months ago I evened out n quit losing weight. My bmi is healthy and my body likes it here. Won't gain weight, and I have to hustle to lose any. So I began weight training and I'm seeing my body tone without much going on on the scale at this point. My family has a risk of heart disease and attack. I've been told by family members that I'll join those ranks by eating the way I do. Well, I might already have a hole in my ship with the genetic lottery I got but I want to be happy and healthy while I'm here. I can do so much more now than before and I feel so much better. I rather have 60 happy years than 67 fat and unhappy years

[@yohanj627]

When you say carnivore, do you add any vegetables?

[@Tod_oMal]

If I tell my Cardiologist that I believe in Saladino's theory, he will die of a heart attack.

[@adamletschin7759]

Well you should probably find a new doctor because the statins he prescribes you will do much more harm then animal fats.

[@jameskearse8617]

He probably eats too many veggies

[@destro1989]

@@adamletschin7759 That's verifiably untrue.

[@adamletschin7759]

@@destro1989 No it's really not. Cholesterol is absolutely essential to proper cell function and suppressing that is not what our bodies need. If you eat a diet full of sugar and processed carbohydrates you are much more likely to have metabolic issues than if you eat a carnivore diet. That is a fact.

[@destro1989]

@@adamletschin7759 metabolic issues is a general term. The anecdotes I've seen are people who need to lose at least 40lbs. If you're 40lbs overweight, you're obese likely in the 30-40 BMI range if not more. Metabolic derangement including dyslipidemia and pre diabetes / diabetes are highly likely at those weights. The effects of weight loss are not mutually exclusive to the carnivore diet.

[@riffism]

There is also strong correlation between coronary artery disease and spikes in insulin. Ive read several papers which draw this conclusion: Sugar is the real reason why we have higher levels of heart disease despite eating less saturated fat over the past 70 years.

[@justaman9564]

Limited research regarding the negative effects of high intake of delta9THC on the cardiovascular system is rather concerning. Found some data after vascular specialists found a 3.2cm arterial blood clot in my femoral artery, at 39yo, and specialist couldn’t hypothesise a cause, as peripheral artery disease is ruled out. And of course been researching all this stuff, and realise due to Cannabis drug scheduling 1 category the research is so limited.

[@gurjastoor9303]

This niggas a g. Hes really passionate about this and is really good at explaining

[@plumdigidy]

A Lemon and lime every morning squeezed with cold water unblocked my arteries. Citric acid cuts through grease quickly. I went from a 72% blockage down to a 43% in 4 weeks!! No need for stents : o)

[@TheSocratesofAthens]

In short, LDL is not as bad as we think, especially when coupled with high HDL. If there's anything wrong with LDL, LDL is a symptom of underlying inflamation rather than the cause.

[@chris-nj3vg]

Wrong: pubmed.ncbi.nlm.nih.gov/28444290/

[@kenerb7318]

You should also check out Ivor Cummins. I believe he and Dave Feldman are collaborators.

[@coffeemachtspass]

And he’ll weep statin Lipitor tears.

[@mikecernile7517]

My triglyceride levels are 2,200. I eat extremely healthy and exercise regularly. I had blood work done ( it’s always been high) but my Dr freaked out. Did a stress test and heart was completely clear. No blockage and no build up. Put me on Vasepa and some other stuff. Drs say it’s hereditary. I’m at a loss and hope the meds work..

[@DNC88]

I would really really get a 2nd opinion on that. Im guessing because of them big numbers, your meds and doses are high and because cholesterol/fat meds are pretty unhealthy for the body, you should be sure you really have a problem. Its a possibility you are healthy, and the 2200 count turns out to have some weird explanation. Whats you ldl, hdl, vldl, total chol count?

[@666j1]

daily reminder that the missing episodes are still not spotify.

[@cameron3525]

Is this episode missing?

[@veverdy7639]

This bloke has a powerful brain 🧠

[@muncheez9325]

I understood maybe 40% of what this dude was saying

[@m0gul666]

This is REALLY fucking interesting, thanks for having Paul Saladino on - I'd love to hear more about this.

[@brokeandbored85]

There wasn't McDonald's, Burger King,KFC & fast food restaurants on every corner back then

[@Maria___28]

Spot on. Restaurants back then were small and mom and pop owed too.

[@ninawildr4207]

@@Maria___28 that cooked in animal fats!

[@wcw7813]

Have you seen this clip of Joe’s guest telling him the new studio is awful?! kzbin.info/www/bejne/l32Vq6OhpbysmKM It’s too funny!!

[@capnstewy55]

One of the big things to remember is humans aren't supposed to live long enough to get these problems from an evolutionary point of view so there would have been very little fitness pressure to prevent problems from cholesterol.

[@Kotaman21]

I had perfect blood pressure and stuff but my cholesterol was high I was pretty surprised cause I exercise everyday and eat pretty well. This video kind of helped explain that

[@Just_logic]

I am a mirror of you. Except exercising everyday.3 days a week. Very sensitive to statin. Libido goes down.

[@MysticButterfly9]

1 year carnivore here, buy Paul Saladino's book The carnivore code. It explains everything.

[@justinfrazier5947]

Humans aren't carnivores.

[@Blackguysensai]

Hes that one professor/teacher who nerds out because he's passionate about what he's teaching but leave you completely lost and confused

[@SenorJuan2023]

This doctor is confused himself. He's promoting complete nonsense.

[@davepeterschmidt5818]

@@SenorJuan2023 Ignore him if you like. Your loss.

[@SenorJuan2023]

@@davepeterschmidt5818 Any long term studies on the efficacy of the Carnivore Diet? No, there isn't. I don't take it seriously for that reason, PLUS it's a devastating diet for the environmental effects.

[@davepeterschmidt5818]

@@SenorJuan2023 Agreed on long term studies. However, indigenous hunter/gatherer societies eat primarily animal based foods with some plant foods when needed. They are normally robustly healthy. I have virtually no concerns about a carne based diet when done properly with organ meats and bone broth and such. As for environmental effects, if the animals are raised on pasture that's completely 100% untrue. Feed lot cattle are a different matter. Those really need to be eliminated, but then so does monocrop agriculture.

[@undisputed6034]

@@SenorJuan2023 there aren't any long term studies on any diet. So moot point. Besides, crops and plants require deforestation and destruction of natural habitat, far more than slaughter houses do. Far more. In fact we will no longer have an 'Amazon rainforest' in the near future because of vegans and their soy.

[@sspbrazil]

He doesn’t mention that the cholesterol hypothesis we use today is based upon one small study from the 50’s, I suggest reading “The Cholesterol Myth” by Uffe Ravnskov, he was the first to explore the myths about cholesterol. I read it in late 90’s and it is a very good book.

[@MP-tj5xv]

I read it too. I was competing in fitness back then, and that book made me keep the egg yolks in eggs. I was removing them previous to that read. It is a great book that explains it very well.

[@shadsalah3346]

uffe ravskov is a quack.

[@sspbrazil]

@@shadsalah3346 no he isn’t troll.

[@shadsalah3346]

@@sspbrazil yeah he is a charlatan who cherrypicks studies. he is only fooling morons that dont understand the science behind it.

[@sspbrazil]

@@shadsalah3346 he didn’t cherry pick anything, he pokes a lot of holes in the cholesterol hysteria by doing a ton of research and still to this day how cholesterol is treated is based on 2 small studies from the 1950’s. High cholesterol in of itself is benign. The are over 100 different causes for heart disease, high cholesterol being very low on the list, also people with higher cholesterol are less susceptible to contracting common viruses, in fact, look up the correlation to higher cholesterol and it’s protection against COVID. There were several different research papers published to the effect that it was better not to lower cholesterol in people with higher levels during the pandemic because research had revealed that it was protecting the mine system which lowered the chances of contracting the virus. Cholesterol is very important to our immune system and liver function. You obviously have no clue as to what you are talking about and what science? I’m talking about science. I can bet you never read any of Raskov’s books or have actually seen any of his research or a host of other research like Rogan’s guest here.

[@dalejames486]

The spike in cardiovascular disease that Joe begins the conversation with speaks volumes for how far modern medicine has progressed. Cardiovascular disease, cancer, neurodegenerative disease, used to be a rare occurrence in nature. Even 100 years ago, the flu was deadly. I think this is an overlooked factor.

[@dalejames486]

And by the way, I LIKE the new studio. 🖕

[@nicolascrisafi787]

I have been studying this subject for countless hours, and yet 2 very important questions remain: how much + what kind of carbs are needed, combined with high LDL, to start causing atherosclerocis? If carnivore and keto people have very high LDL, and if our ancestors had very high LDL because they were often fasting, but also eating almost only meat for 90 000 years during the ice age, then it is not high LDL alone, but the mix of high LDL with other variables that will cause clogged arteries (although I am aware you can clog arteries with low LDL too). But who is more at risk? Low LDL people who eat like $hit or high LDL people who eat like $hit? That is the first question Now let's say a 200 lbs bodybuilder eats 9 eggs per day, 2 lbs of extra lean ground beef, but also 350g of carbs daily (rice, veggies, fruits), and avoids sugar and seed oils. Let's say he also has very high LDL, like 220, and has fine HDL and low triglycerides. Will he develop atherosclerosis just because of the huge amount of carbs combined with high LDL? Or is he fine because he is metabolically healthy and the carbs are not refined sugar? When a lot of "good" carbs are combined with high LDL, can we still clog arteries? I see all these doctors saying high LDL is not the cause of atherosclerosis, and I believe it, but I have seen athletes clog arteries at 40 years old. They had great cardio and avoided sugar. Is it really only because they replaced butter with margerine? Or is it because they had too many carbs even if they were not sugar? That is the second question and I haven't seen any doctor tackle it yet. What matters most: the quality or the quantity of carbs?

[@rockyr2454]

I miss that CA studio background

[@jimmorrison4163]

this video deserves much more views.

[@heavymetalcreationz711]

So many questions… I wish I could’ve called into this show!! I have elevated LDL, I am lean, I’ve always maintained a healthy diet. No sugar, no seed oils, I limit my carbohydrates and use them in a strategic way. I am not on HRT or any type of performance enhancing substance but… My HDL has never been great. I usually sit in the high 30’s to low 40’s. I exercise regularly, including HIIT style training. I supplement EPA and DHA in pretty high doses (2000mg a day), but I still seem to struggle with my HDL numbers. I can’t imagine that I am at all Insulin resistant, my fasting insulin levels have always been great. I’m not sure how to address this issue.

[@lpg12338]

An oral glucose tolerance test (OGTT) will tell you if you are insulin resistant. Also, do you ingest extra virgin olive oil. Also, take a look at K2 vitamins and hawthorn extract. Stay healthy! 👍

[@heavymetalcreationz711]

@@lpg12338 I actually use olive oil, I also take tocotrienols and K2. I haven’t tried hawthorn yet.

[@gregoryelliott2238]

Since I added a couple large handfuls of nuts and eating avocado everyday, my HDL finally is in the upper 50's after struggling for years in the low to Mid 40's

[@PairamaMoon]

You need to get this guy on with Peter attia as he disagrees with Paul on this point

[@JakesOnline]

High LDL when you burn fat. High LDL when it's used to repair damage from sugar. When your house burns down, you don't blame the water used to put out the fire.

[@ucchi9829]

What a stupid analogy. You clearly have no clue what the etiology is.

[@JakesOnline]

@@ucchi9829 I appreciate constructive criticism. Your comment doesn't qualify, but I forgive you.

[@ucchi9829]

@@JakesOnline What do you mean it doesn't qualify? You don't just have elevated magnitudes of LDL-C per some special "fat burning" stage. I have seen some posits on this but the variance isn't explained by just "ketosis". The high LDL-C could be due to diet (SF intake over 15g per day or eating over 100mg of DC per day) or SNPS. Your analogy tries to downplay LDL's role when it's a clear intendent risk factor. Actually it's causal to ASCVD.

[@JakesOnline]

@@ucchi9829 Thank you for the info!

[@davelospinoso9022]

@@ucchi9829 LDL is equal concentration in both arteries and veins, why does it only harden arteries?

[@laeitdown]

Love to chat with this guy. I'm 6'1, 190lbs with High LDL which lead to a heart attack. We still have trouble getting it down with medication. I believe having a high metabolism and not doing anything with it leads to it. My HR only affected one arterie, others clean. Also, no heart or chest pain, felt like indigestion. Also, seen before my HR and gave no thought to it but after I did. I seen if you have heart issues you will have a zit on your left shoulder. I have and still do, but before my HR I could pop it every week, it doesn't go away. After my HR I was amazed at how little scientists and doctors actually know about the heart and signs of heart attack. My signs weeks before, waking up breathless, waking up in a sweat soaked bed head to toe. And I began having a lot of teeth issues I think was due to heart.

[@tl4702]

Cholesterol itself does not cause heart disease. You must have either a genetic condition or you have chronically high blood glucose and inflammation which damaged your artery wall and at that point cholesterol can get trapped

[@laeitdown]

@@tl4702 I feel I am an anomaly, I never had high blood pressure. For decades before my HR I would get cramps below my pecks, and would sometimes when hot begin sweating and couldn't stop. Also, all my heart like episodes happened while I was sleeping. Daytime I would be fine, but day leading up I couldn't lay down, slept sitting for 2 nights due to strange indigestion feeling. Note, it does run in the family. I just think it's wild that it's only 1 artery and others are perfect. I do feel due to me having a high metabolism and not exercising or playing a sport is a key. I have always been and still am a person with high energy, when I work I work hard.

[@hesitatenothing]

@@tl4702 It can defiantly can cause a heart attack, i work as doctor. And most patients suffered stroke or heart attacks have been carrying high cholesterol from what i've seen but not all of course. Has also been reports with this in US health sites.

[@OsirisEyeOpticalSociety]

But Joe did you ask him about DMT? Is it bad?

[@jayswavely6371]

I work out 60+ minutes a day, have low blood sugars, eat well and am 168 pounds at 5'11".