277 ‒ Food allergies: causes, prevention, and treatment with immunotherapy | Kari Nadeau, M.D., Ph.D

[@PeterAttiaMD]

In this episode, we discuss: 0:00:00 - Intro 0:00:42 - Kari’s motivation to study food allergies 0:06:08 - Overview of the immune system and the family of immunoglobulins 0:10:37 - How our immune system fights viruses, bacteria, or fungi, and some exceptions to the rule 0:16:23 - Why our immune system is generally better at fighting viruses than bacterial infections 0:23:41 - Differentiating a food sensitivity from a food allergy, and a discussion about celiac disease 0:34:38 - How food allergies develop, why they can be lethal, and factors contributing to the uptrend in food allergies 0:50:11 - The role of environmental factors in the onset of food allergies and strategies for prevention 1:05:02 - How immunotherapy helps to overcome, and even cure, food allergies 1:26:21 - Can immunotherapy work for environmental allergens like pollen? 1:28:03 - Air pollution: impact on health and tips for reducing your risk 1:40:40 - Resources for those wanting to learn more or find clinical trials related to food allergies

[@Dina379]

Just came across your channel and subscribed ❤thank you for your work! I love your book Outlive ❤️👍

[@mrdrsirmonaco]

This is one of the best podcasts so far imo - she was a great guest and educator

[@Cegros]

Haha, her genuine smile at the beginning when talking about her PhD! That’s real! That’s who we need working in these fields! That’s going to be me!

[@dionysusnow]

i've allways found it pretenous when PHD's insist on being called DR, but I guess I'd be the same if I spent that much time, mondy and effort on something.

[@J9Castle]

Thank you for this! I love her ability to explain exactly what’s happening with these immune mediated responses. I learned so much more what was happening to my daughter, who is now 9, with multiple food allergies as a baby. I breast fed her, exposed her early and also was using natural products. I had to avoid milk then eggs and tree nuts, peanuts in order to clear up her reactions while breastfeeding. We luckily found a therapy for her to start at age 5 for her ANA allergies and sensitized allergies to milk, egg, tree nuts, seeds and peanuts for 4 years and the end goal is food freedom. We are currently daily taking what once we’re ANA allergies. Look up Southern California Food Allergy institute if you are in southern, CA. It is an amazing/outpatient program for kids in OC and San Diego now.

[@cassandra79727]

I have my daughter in SoCal too! She’s anaphylactic to all nuts and peanuts. She up to 5 peanuts a day and can freely eat almonds, Brazil nuts, hazelnuts, pine nuts, macadamia nuts! We have about a year left and she’ll have complete food freedom!! I’m so glad your daughter is working her way through the program too!!

[@kr0207]

Thanks Peter. Great episode. As a father of a child with peanut allergy, this episode has answered lots of questions that I had. Nobody told me that epipen needs to be titrated as the child grows.

[@felipemorales6181]

That's the difference between Peter and everyone else. He is a top interviewer who gets the top scientists in the world.

[@beachnap]

I had no idea that the exposure via skin was such a prominent element to developing allergies. This is so helpful, thank you!

[@ruthbiafora5443]

This is one of the best podcasts and I have already shared it with so many friends. My parents let us have so many pets, and we played outside all the time, and my vitamin D levels were always top-notch and still are. I truly haven’t been sick a day in my life because of the dirt hypophysis.

[@victorianalin5885]

I have Mast Cell Activation Syndrome and am histamine intolérant. I believe this is an underdiagnosed and largely unknown but potentially widespread condition… my mother is 80 and has had various allergies (food/medicine) all her life and has only just been diagnosed… all the research and experts on Mast Cell Activation Syndrome are in the US. Would love a discussion on Mast Cell conditions

[@stephanieritz9165]

I would also like to hear more about this too. It's a condition that's on the rise, but gets little attention.

[@anthonyszymon3032]

Living with an incurable disease is so hard, but you just have to live life day by day as it goes by (Cancer sucks)...

[@nancysainhigh1354]

It’s never the end of the world, but all problems can be solved. I never believed in miracles until Monica Erlene Mora helped me save my son.

[@anthonyszymon3032]

Who is this Monica Erlene Mora? And how can I get in touch?

[@nancysainhigh1354]

You can check her on the web. you will find all you need

[@aragaomrcl]

Petter, I could not thank you enough for this podcast, this knowledge, really very helpful. But I can do it is to let you know how your work is improving live quality of people arround the world, not only US. I am from Brazil and I can assure you that you have a lot of followers and fans down here. Thanks again!

[@jeffreyharrison4045]

Fantastic show. Please bring her back soon!

[@ConsiderItHealth]

Excellent. Loved this entire episode. Dr. Nadeau is such a great speaker. You can tell she is a brilliant, yet a compassionate doctor, who has a gift for teaching.

[@77777jetta]

Wow! What a great podcast! Love my Attia! Having food allergies and medicine allergies myself is tuff! Thank you for the great information!!! 👍

[@elisartil4341]

During fires I get a standard box fan and tape a merv 13 filter on it. Although it's just recycling the air and co2 builds up a bit according to my particle counter, it's still a good cheap solution for me. The Corsi-Rosenthal Box design is the most effective but a bit too overkill for me.

[@szghasem]

Thank you for sharing this talk! So educational, empowering and entertaining all at the same time !

[@blackheart909]

Growing up, I was allergic to coconut and hazelnuts. However, in my time in university, I unintentionally cured my allergies when I used to take diphenhydramine Niquil for those looking for the brand name. I would take diphenhydramine at night for a few days after which at one point, I decided to try some Nutella to my surprise, I wasn’t allergic to the Nutella and one day when I wanted to prove my allergies to a friend of mine who didn’t believe I was allergic to coconut, I bought a bounty bar and proceeded to eat it in front of her to my surprise. I had no allergic reaction like I did when I was younger and this is probably because I took a diphenhydramine pill the night before since then I have stopped being allergic to coconuts and hazelnuts, and now eat them with no antihistamines in my body, I believe I desensitize myself by eating them under the effect of antihistamines.

[@philosophicalmonkachu7711]

Please 🙏 sir,Requesting for a part 2 .... Really appreciate it ,sir and ma'am thank you for your help 🎉...

[@imajem]

6 years ago, I found I have an allergy to rice and an intolerance to onion. I almost never ate rice, so I thought. Onion in some form was multiple times per day. I have found that rice and/or onion is in most processed foods.

[@tonaruch8623]

What a powerful WHY from dr Nadeau

[@karenlopez5441]

Regarding food allergies in an infant and your skin introduction theory, my child was exclusively breastfed until over 6 months. She had severe eczema from 2 months on and at 6 months after I ate cashews and nursed her, she immediately got a very bad exacerbation like road rash all over her face. I quit all nuts immediately and wllgot her in to an allergist at 10 months. She has milk, egg, all nuts, shrimp, mustard and sunflower seed allergies and is 19yo. She also has had asthma (since 2-3 yrs) and seasonal allergies. Can allergies start in utero? Family history of asthma but not severe food allergies. My personal theory was the 3 rounds of antibiotic I got in labor/delivery (they said due to my lengthy labor) for Group B strep which I think wiped out her gut flora.

[@AG-nm1mm]

I have the same experience. I also had three rounds of antibiotics because of the same reason My child is almost 10 with multiples food allergies. I am quite sure antibiotics disrupted my intestinal microbiota and affected my baby. I think fecal transplantation might be a way to cure.

[@tatjanaaustin9225]

How about fecal transplant?

[@stephanieritz9165]

Dr. Castells at Brigham Women's has a great talk on KZbin about this.

[@jasocaz]

PSA: most residential AC units are not equipped to handle over MERV 8. Would definitely consult with an HVAC tech before installing MERV13 filters.

[@riceexperiment]

13:00 great break down in lay terms of the immune response

[@cypherblue2665]

No mention of the correlation of childhood vaccines and increase in allergies in the western world but not elsewhere? NB: Attia is a still big fan of Covid vaccines which should tell you something

[@sookie5592]

Very very disappointing.....

[@etalgovez5671]

Such a tragic story the outdated epipen. After having renewed the epipen, before disposing the old one, it is good to practice with the outdated epipen, by giving the injection to an orange etc. When your child has anaphylaxis, the situation may be so chaotic, that routine gained by prior practice may be life saving.

[@quitracks]

Can this theory be applied to autoimmune disease? So can you train immune system to not attack a person's thyroid, hashimotos, by taking small doses of thyroid gland?

[@anonymoususer7606]

I was wonder the same thing. There is a doctor Clemens with paleomedicina in hungry that treats perhaps reverses autoimmune diseases mast cell activation, etc using a paleo ketogenic diet also like a ketogenic diet carnivore diet that is dairy free

[@Sanjuro806]

Excellent education. 🎉

[@redinator9896]

This reminds me of eating hot peppers, and avoiding drinking water during consumption. Something builds resistance and your taste recalibrates to handle more capcacin.

[@B.-gb2sh]

Wow, great episode. very informative. I grew up with asthma. I have developed a shellfish allergy later in life then even later (10 years) developed a fish allergy so now I can't eat seafood. I was now recently diagnosed with Eosinophilic esophagitis (EOE) I Would love if you could do a follow up episode on allergies and EOE it's wild the rise in EOE right now and how so many ppl are getting it. It was unheard of in 1980. This could be because of several reasons but very interesting nevertheless.

[@jjuniper274]

This is wonderful information.

[@eliteboxfitness]

Thank you . Great breakdown

[@LiamGandelsman]

Fascinating episode

[@evarlast]

~18min question - most people don't go 2-3 yrs without needing an antibiotic? reference please? my anecdote: I haven't taken an antibiotic in 20+yrs.

[@jackthebasenji1]

My son is 15 and has a wheat allergy since 6 mos. If he gets enough wheat he needs an EpiPen and visit to the hospital.

[@lucagonnet4784]

air purifier with Hepa filter + active chaorcal filters is sufficient to reduce pm 2.5 ? Anything else?

[@ayatattar4935]

Did anyone write notes ?

[@insightfool]

Isn't colic a case where the baby has an allergy to the mother's breastmilk? Seems pretty common.

[@zacharyswain7034]

has immunotherapy been tested for people with sensitivities to work?

[@Geezerelli]

Work with the FDA😂 Rand Paul would disagree!

[@Optimization_Coach]

For good reason. How on earth can anyone trust them after C19?

[@MatthewPearson]

Sorry Peter but you can't seriously believe that we develop allergies via airborne exposure through the shin. This woman is out to lunch. Just another great example of the state of our education system

[@markhouseholder]

Not the mask lie… you just lost me….

[@susiehannan3368]

Thank you for this! As a school nurse this is a top 3 priority item for me on a daily basis. Can you clarify the timing please of the second Epi injection? You are recommending if symptoms still persist after 1 minute. I have always been taught around minute 5. Much appreciated, thank you!

[@kimberlyf4888]

I grew up with a multitude of allergies, both food (milk & wheat) and non-food. Grew out of them all by my teens. I was bottle fed, and in home with a very heavy smoker. Thankful that with my daughter I breastfed, did not over-wash her, had a dog and introduced a myriad of foods all at once when she moved to solids. I figured if she had a reaction when eating we could always go back to the one-food-at-time method - but it was never necessary. She has rarely been sick and has no allergies/sensitivities.

[@Notsorandomwalk]

What about increased antibiotics use leading to increased food sensitivities? I suspect that was a huge factor in my own development of food sensitivities as an adolescent.

[@elizabethwilk9615]

Good question. I’ve taken many and my women friends due to UTIs and we have all developed allergies.

[@evasz814]

Thank you for excellent presentation. I lived in Ontario, Canada. The government takes away a lane converting them to bike lane. Now the commuting cars create slow traffic and many times traffic jams. You see probably max 5 bikers a year. So now the pollution is drastically increased. Not only that, the bikers inhale the exhaust from the cars. I love biking, but I would never ride in traffic. Do these government people do any research before they close lanes??

[@happynjoyousnfree]

I used to think the gas and bloating was due to stress, but I've learned that certain "healthy" foods cause it, like beans, nightshades, and cruciferous vegetables. I take Beano if I eat these foods and it helps, but it doesn't make it go away completely, and if I keep eating the food, it gets really bad. I appreciate the distinction between food allergies and food sensitivities.

[@FreeCuban00]

Love love love this podcast ! I have listen to Dr Attia before in another channels but not subscribed to his own ; I just did ! Thank you for so much information.

[@LNB259]

The epi & avi pens are still way too expensive - $200-$300.

[@penstonecipher8259]

And if yr anaphalactic?

[@karenbruckner4103]

Was wondering if excipients( eg lactose, glycerine or other proteins) in infant & children vaccine injections could play a role in the later development of food allergies. These intramuscular injected stablisers and antigens essentially bypass the gut and enter the highly protected and sterile systems of the serum/lymph?

[@FitKaurTraining]

What a great guest! Please have her on again.

[@nda4591]

Great conversation! Thanks for sharing!

[@AAAAAA-fj3dh]

Low testosterone will also give dry skin.

[@ryu778899]

Would be interesting to hear your version on the norwegian model training. Yeah they do mostly zone 2 (they call it zone 1 in a three scale) but the lactate threshold/anaerobic threshold is something I havent heard you talk about. You mostly talk about zone 5 when it comes to anaerobic exercise and Im curious to hear your take. Thanks for the knowledge!

[@orbifold4387]

Not even in the podcasts with Iñigo San Millan?

[@ryu778899]

@@orbifold4387 i dont know if im confused by all the terms: Aerobic threshold, anaerobic threshold and lactate threshold. To me it sounds like that norwegian model does some form of zone 3 just above zone 2 ceiling, lactate threshold/anaerobic threshold (guess its the same thing). Aerobic threshold is top of zone 2 right? However if this is the case, than i would like to know more about this zone 3 anaerobic/lactic threshold thing since its not zone 5, and is it maybe a better option or not. I know theyve talked about norwegians and thresholds but never this specific zone 3 thing.

[@jjuniper274]

When I was pregnant a campfire made me sick, and I couldnt go to the new grocery store. The glue from the new floor made me sick too.

[@sjg6904]

I’m allergic to all citrus fruits and veggies… any hope?

[@linzarzar6992]

great podcast

[@eloiselovesdevi]

Such an interesting podcast!!

[@DaboooogA]

Great discussion thanks

[@nichtsistkostenlos6565]

This was a good episode, but Kari really needs a new term besides "the science", holy shit does that get grating the one hundredth I hear it in a single interview.

[@vitalynewman1315]

Thank you!

[@caustinolino3687]

So in 20 years when 1 in 10 adults and 1 in 5 kids has to carry an epipen, will we be any farther than vague hypotheses about why this is happening? It's only been several decades so far...

[@riceexperiment]

Research has come so so so far! We can detect physiological changes specifically and in general practice settings that we couldn't do before. For instance, the understanding that some drug allergies are actually related to petroleum in drugs products (i.e. PEG derivatives) cause "allergies" because we have made antibodies to the petroleum derivatives (or beauty products mentioned here)

[@horseradishwithchives]

It's the mystery juices people are injecting + fake food w/ pesticide use + airborne spraying. To mass produce food and make bank you need to cut corners - powdered milks, force-feeding chickens with literal feces, GMOs, gluing scrap meats together and selling as fake portions of cow. Read about how McDonald's fries are made. Read what home-hardware chemicals they add to lucky charm cereals. "Re$earch" is gatekept by pharmakeia.

[@williammaurer9450]

Excellent guest, info, discussion, ... TY TY.

[@angelacacace3705]

I am completely blown away by this information!!! I have suffered with allergies my entire life.... When I was a child I was allergic to peanuts, my cats, dogs, and horses.... dust, grass, weeds, and some flowers blooming...alfalfa, eggs milk, and chocolates... Then ironically enough I seemed to have grown out of the food allergies to milk, eggs, peanuts and chocolate but retained the allergies to cats, horses, dogs, and alfalfa,grass, and weeds/etc.... By the time I was a teenager I started having massive anaphylactic allergies towards avocados melons, peanuts, tree nuts, bananas mushrooms, crab, and shrimp....I am so hopeful right now!🥲 If there's even a small possibility of relieving my allergies to my animals and even just the possibility of eating avocados again... is just something I could only dream of achieving.... Thank you so much for having this conversation on a public platform. I am so amazed right now! Thank you🤗🥲

[@eunicelee5078]

Hi, I just wanted to say that you might want to look into histamine intolerance or mast cell activation syndrome.

[@angelacacace3705]

@@eunicelee5078 Thank you. I will 😊