Pharmacokinetics and Pharmacodynamics

[@DirtyMedicine]

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How to join the channel

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How to join?

[@annemarshall752]

The fee for monthly membership is not 4.99 it's showing 9.99. Is this correct?

[@MsPriyanka6]

Hi, I finished my step 1 on July 30 and got 238. I am so happy. Thanks to you atleast i got 10 or more than 10 questions correct only because of dirty medicine videos. Thank you so much 🙏🏻🙏🏻

[@TravelTherapy022]

Sounds great 👍

[@sandhya797]

Which ones do you recommend?

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Great yarrrrr

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Hi. How was your experience about Step1?

[@simplex6941]

You think you're smart, how much Tylenol does it take to blow up Albania. I will be waiting.

[@BangtanNaruto]

Mnemonic for drugs that follow 0 order kinetics: Zero WATT Power. Zero: 0 order kinetics W: warfarin A: alcohol T: Tolbutamide T: Theophylline Power: Phenytoin

[@user-ep5pf4hb3q]

erm, what the sigma?

[@fatimakhalid6010]

What about aspirin

[@BaoNguyen-hb9ur]

I hated this subject so much while in school. The way you’re breaking this dry material down is amazingly good Thank you!

[@User-s868]

I’ve been searching this subject for two days!! Couldn’t find something simple Expecting this to be the answer Thank you

[@videoinformer]

One unstated fact that needs to be made clear: Reaching "steady state" requires *repeated* constant doses of the drug being taken, not a mere single dose followed by a number of half-lives. Taking a drug once will result in elimination until it's all gone from the body, never reaching "steady state". Another subtopic worthy of attention is the affect of an initial *"loading dose"* (typically a double dose) on kinetics and attainment of steady state at a serum level that is still determined based on the subsequent regular dose -- *not* based on the loading dose. Naproxen is a familiar nonprescription drug that has label directions that allow for an initial *double* (loading) dose followed by the normal dose at regular intervals of 12 hours.

[@DirtyMedicine]

Yes to reach steady state there must be constant dosing, this was implied

[@Aviation_Professional]

@@DirtyMedicine Yes it was...

[@Guidus125]

I was looking for this comment, because this was indeed not mentioned clearly in the video. Imagine a single dose getting you to steady state and that the level of steady state would depend on the size of the dose... That means if you get high once you would be high till eternity hahaha

[@StarBuilder222]

This!

[@itsgonnabeanaurfromme]

@@Guidus125 that needed to be explained? He said "you're taking the drug as prescribed", not "you took the drug". These videos are designed for medical students so it is expected people watching would have at least know these things. But it is understandable it may be hard for you if you have no medical background.

[@greyeyedone_2119]

Thank you for breaking this down for me… I don’t understand why professors try and make the topics difficult instead of breaking it down for easier understanding…🤦🏾‍♀️🤦🏾‍♀️🤦🏾‍♀️

[@kpulkit5627]

Ive seen a question solely testing on this same principle that the first part of the elimination graph for 1st order kinetics Is not the elimination but the redistribution itself! Amazing work as usual Dirty !!

[@givenmichael6177]

He said its distribution

[@HenryRph]

This was the most instructive insightful easily understandable video on Pharmacokinetics I have ever encountered on video and in Pharmacy school!!!!

[@greyeyedone_2119]

exactly… I have no idea why professors make this subject harder to understand than what it needs to be…then get upset when you somehow don’t understand… plz make it make sense……

[@IonVama-yn7ij]

That very well explained and easier for me to remember the mechanism. Thank you

[@bronxbomma718]

This is the most banal and stale material on the boards. You somehow, found a way to make it pleasant. Kudos.

[@chefinwhitecoat]

Just watched the whole thing in one min, I am getting better

[@SpeedyMedical]

Was tryin to study yesterday, couldn't understand much , thanks for always being there!

[@komaldiptianandmaisuriya4301]

Thank you so much for all your video especially biochem & pharma .you make it all easy . ❤️

[@kalabid9617]

So lucid and clear ! Keep posting more !

[@nambozohadija3023]

What a Wonderful summery. Thanx big, bless u

[@vaishnavishashidhar9686]

Thank you so much!!! You’ve made it sooo clear, can’t thank you enough

[@carpe996]

Good lecture overall. Though probably not pertinent to USMLE questions, I would point out though that 1/2 life is NOT the time for which 1/2 the amount of drug is eliminated from the body, but the time needed to cut the the plasma concentration of a drug in half (and those measurements are not the same nor the same amount of time required necessarily ).... A clinically relevant clarification, though, again, maybe not important for USMLE purposes. I am a physician/pharmacist.

[@Alihaider-he1be]

Dude, what you are talking about is clearance not half life he explained right

[@carpe996]

@@Alihaider-he1be you have it backwards.

[@adityaoruganti9307]

Soo needed this at the moment You are a savior angel 🤟

[@DrSajjadPathan]

So Clearly explained. Keep up the good work. Thank you

[@nesisamoyo6904]

wonderful stuff keep going, I now know everything about steady state and pharmacokinetics

[@shanthisenthilkumar3831]

Awesome presentation. Thank u

[@imsuperioroso]

Nucypher and DOGEcoin to the MOON! 🚀🚀🚀

[@Vunami]

sir stop talking about crypto in a medical channel

[@imsuperioroso]

@@Vunami med students have student loans to pay and investing may help pay them off sooner

[@aqsafatima9102]

Please please dirty make one video on renal pharmacology. I wasn't listening to u before. But i just started with one and it went on. Now i really really feel something missing when doing renal pharmacology. Please make one!

[@Mdepaivaoliveira]

Great video. Thank you very much

[@MuhammadAli-jd2ut]

Appreciate your work 👍.

[@habakkukwilsonik2740]

Wow, Exllent explain 👏👏🤝🤝

[@Timtam973]

Amazing lecture!

[@Shivoham2243]

Thank you❤

[@ambreensabah3758]

Need of the hour sir

[@meimei2630]

thankkkkk youuu for updates! thank you

[@darillynn]

Thank you! Can you please make a video on diuretics?

[@pcdihealth]

Great Video

[@somethingsafoot]

FOR ALGORITHM TAKE MY POWER I TAKE THIS NEXT SEMESTER

[@SalmaSaifuddin]

i wish i could send you my tuition money instead of giving it to my school

[@xaaboopinkly]

Thanks sir!

[@jaehaerys9194]

300likes... i am not going to ruin it by clicking it... but i really do like the video

[@IsaacSagoe-p9b]

Thank you very much

[@MelisaManase]

Thank you

[@danielmacedo4417]

Are those equations about Loading Dose and Maintenance Dose High-Yield for the Step 1 or not that much?

[@lalitsiriatti1717]

High yield.

[@indiandancey]

THANK YOU dirty!!!!!!!!!

[@nuckchorris1396]

U the best

[@jeminiperera]

Good one

[@Danielmulenga-s5u]

Powerful

[@rebazothman1506]

Tysm!

[@FrankGbenyade]

Thanks sir

[@plutobaby9996]

this video is so clutch

[@Nomad278]

Where can i find a video of Henderson-Hasselbalch equation?

[@raynaboyarsky4591]

thank you !!!!

[@1412Z]

Thanks!

[@martinkral7222]

Does this apply to vaccines?

[@annemarshall752]

The fee for monthly membership is not 4.99 it's showing 9.99. Is this correct?

[@kmags8065]

HI this is very useful and informative video ,but what about pharmacodynamics ,do we need to subscribe first to get the rest of the video?

[@jaxonvictoria4345]

The bulk of pharmacodynamics is pharmacology and all the clinical topics.

[@abdu170]

Thank you very much!

[@jonasesenwein3189]

Nice

[@smallpharm13450]

OK sir

[@franciszoballah4722]

Great

[@drismail469]

thank you so much

[@DrUsamaCh98]

👍

[@alimahmoud9334]

good

[@alvaro37nf]

Dirty, what is your opinion about AMBOSS?

[@DirtyMedicine]

my opinion is that its okay to use but that I think UW is better if you have to pick one

[@alvaro37nf]

@@DirtyMedicine thank you for your response!

[@ekanki07]

@@DirtyMedicine How essential do you feel Boards and Beyond is to Step 1 Study? (if using UW and your videos)

[@jaymata1218]

11:03... thank you kind sir

[@joshmcgoo]

COMMENTING FOR THE LGORITHM

[@medicallife3738]

Hey dirty please make video on pprf lesion

[@itsLannoh]

''''''''Elimination refers to the volume of the body cleared of a drug over a unit time'''''''' do you still agree😄😄

[@medstudent26FL]

thank you dirty!!!!

[@sinajamali-s1l]

[@hritvikjain__3594]

commenting down here for the algorithm

[@Shashani2000]

Shamail shakir

[@tubby7817]

For algorithm

[@nafissajid1]

🎉😅❤

[@TheSharan12]

good lecture and a better understanding thank you will continue watching your pharmacology lecture please subscribe to this channel

[@Physiciansdesk]

Aspirin phenytoin and …? Zero order ! Answer

[@amandalmia1998]

PEA in zer"O" - Phenytoin, Ethanol and Aspirin.

[@TheSharan12]

ss

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1 day too late

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Please change the name of the channel. There is no dirt in medicine

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thank u so much

[@danatnanle126]

Nice one