Taurine: A Savior against Metabolic Syndrome… or is it?

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References
[Study 347] Tzang CC, Chi LY, Lin LH, et al. Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Nutr Diabetes. 2024;14(1):29. Published 2024 May 16. doi:10.1038/s41387-024-00289-z
Public Funding: National Taiwan University Hospital and the Ministry of Science and Technology // No Conflicts of Interest
[1] Sun Q, Wang B, Li Y, et al. Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. Hypertension. 2016;67(3):541-549. doi:10.1161/HYPERTENSIONAHA.115.06624
[2] DiNicolantonio JJ, OKeefe JH, McCarty MF. Boosting endogenous production of vasoprotective hydrogen sulfide via supplementation with taurine and N-acetylcysteine: a novel way to promote cardiovascular health. Open Heart. 2017;4(1):e000600. Published 2017 May 22. doi:10.1136/openhrt-2017-000600
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#taurine #metabolicsyndrome

[@joel6427]

According to my most recent blood test, all I know for sure is that after starting every day for the last 8 months with a shake containing 12 gr of taurine, glycine, NAC, KaChava nutrient mix, and both soluble and insoluble fiber, My Triglysorides are 33, and my HDL is 46, giving me a Triglysord to HDL ratio of .72. The ideal level, according to Dr Lustig, is 1.5 or less. As an unexpected side effect, I have steadily lost 15 pounds. At 77, I can't remember feeling this good, having this much energy and forward-thinking attitude. So many of my peers talk about this and that health issue, while I have none. I am so frustrated by those around me who refuse to share my excitement.

[@waris4thewealthy549]

A great line to remember for your frustration..."in the land of the blind the man with one eye is king"....I stop telling people about the benefits of supplementation a long time ago unless they ask me about my health ways. Their doctors have them in the bag hook line and sinker...congrats on your improvements! 😁

[@changegears7712]

For clarity. You’ve been taking 12G of taurine plus the other things, or 12G of a mix of all the supps you mentioned??

[@waris4thewealthy549]

@@changegears7712 has to be a mix...at least that's the way I read it, "supposedly" you can max up to 6G...🤔

[@conceicaod]

@@changegears7712 12g of taurine seem very high

[@rowanedwards235]

Likewise 💜✨ I also chose NOT to succumb to mRNA gene therapy & I'm very thankful, particularly as I am witness to innumerable sudden deaths. Is that outcome simply a dynamic of my age ?? Maybe.. lol 😅

[@123Goldhunter11]

At 74 I was having trouble fingering my guitar chords. After a few months of taurine it seems to be 90% better. Excellent work per usual. Thank you.

[@michaelhalser]

"guitar chords" is an odd name for a lady.

[@brendanfitzpatrick3824]

​@@michaelhalser that's not the lady's name it's anatomic description. I can't tell you my guitar's name because it's a secret but they all require fingering.

[@Moni-ui5bz]

My senior dog started having seizures at age 11. among other supplements he's getting Taurine every day. He's been seizure free since March 2023 now and he's almost 15 now.

[@douglaslegvold9215]

I’ve been supplementing my best friends meals everyday

[@danielweyhrauch2953]

Have had multiple visits to the cardiologist and the ER I found Taurine and it has been a lifesaver for me. I’m able to calm down my heart rhythm fairly quickly. Thanks,

[@Physionic]

Cool!

[@D56t37-cu7ol]

@@Physionic I take taurine (and magnesium) before I get in my ice tub. My heart doesn't beat as hard or fast and doesn't skip a beat...It makes a noticeable difference...

[@MrAZemitis]

@@D56t37-cu7ol I like taking taurine before public speaking, makes you mellow and chill

[@belvederebaileycambodia]

@@D56t37-cu7ol Atenolol. You'll wish you had discovered it 20 years ago. My honeymoon period with Atenolol lasted for about a year, where, every day, I was aware of how wonderfully slow and unobtrusive my heartbeat was. Now, it's still wonderfull not having those terrible ectopic beats and pounding heart, but I'm not as aware of it as I once was. Add Taurine and Magnesium... you'll live to be 120.

[@Eric3Frog]

How much do you take? How much do you weigh? How many times per day do you ingest it?

[@jaytm2574]

I added Taurine to my supplements a year ago. I have high BP and am insulin resistant, so it's an overall win-win for me.

[@MarcColbeckCCP]

Did it help? Did you see a change in your blood pressure?

[@jaytm2574]

@@MarcColbeckCCP Not significant. It did help with my overall energy level though, so I needed less caffeine during the day - and that did lower my blood pressure.

[@MarcColbeckCCP]

@jaytm2574 Cool, thanks for sharing your experience. I have high BP and metabolic syndrome. I've gone gluten, sugar, and dairy free. It's ... great :-( ... but I'm losing weight and I'm not ravenous hungry all the time anymore. Which is a huge relief.

[@MarcusKarlssone]

@@MarcColbeckCCP add some potassium it will lower BP 185/110 140/95 in two week I do take taurine also, but i have tested only potassium before and got the same good result in 2 weeks

[@MarcusKarlssone]

Potassium citrate

[@thetayz72]

I appreciate you continuing to shed light on Taurine. Please keep us updated with any new developments. I started supplementing Taurine about 1.5 months ago based on your earlier videos, and it could help me stave off metabolic syndrome since I have family history risk factors.

[@totalwayne3089]

How much g a day do you take? I see supplementation of 1.5g and 7.5g If you weight 80kg

[@thetayz72]

@@totalwayne3089 Currently about 3g daily

[@GloriaCote-o1c]

I have been taking it for two years and although I don't go to doctors, I can tell that my blood pressure has normalized. I will keep taking it.

[@Eric-777]

Thank you for your videos. I love when you get into the technical aspects. Although I know many may not enjoy or understand it. I have a biochem background from years ago and of course I love the subject matter still. You have a gift and pleasant way of explaining these studies. I appreciate it very much and I sure other fans of yours do too

[@Bikerman2022]

I've been taking Taurine for about a year. I'm 68 and have not treated my body well over my life. I have increased muscle mass after losing it quite quickly over the last few years due to a world illness but the biggest is my stamina. I dance hard twice a week. Actually I went last night and was literally the last person dancing in a room of a hundred mostly young people. I get so many comments about "where do I get my energy and stamina?" I reckon it's past the point of placebo and I'm not a particularly hyper or overly active person generally. Oh and don't get any stiffness or sore muscles after which I used to get. Interesting.....

[@paulbirkbeck1790]

Thats brilliant thanks for sharing

[@douglaslegvold9215]

N=1

[@paulbirkbeck1790]

@douglaslegvold9215 what is your opinion on taurine? And what does N=1 mean

[@douglaslegvold9215]

@@paulbirkbeck1790 take 3-6 grams a day. Pottenger’s human has great KZbin videos on the subject, he isn’t that big yet because he is good (shadow banned) watch his videos, read his stuff

[@zhilahaghbin4766]

Thanks Dr. Nick for excellent work and content

[@dominikvonlavante6113]

The cellular mechanisms were great. I could listen for hours to such content 😊

[@Danny1.414]

Same here

[@norbertnagy5514]

Sad, that most people want answers in 1 ms, and all they saying is "stop yapping, get to the point already😡🤬"

[@carnivoreRon]

After reading about taurine, I started taking 500 mg a day. Combined with the carnivore way of eating, my blood pressure is low about 120/65. I'm 72.

[@omarsalomcanaloficial3330]

You are awesome man……..a fresh air. I don’t consume any supplement without listening to your analisis

[@jayalanlife5926]

Tnkx Nic, loved the cellular mechanisms in the first bit of the video mate.

[@Physionic]

Me too - thanks!

[@mrmacguffin6886]

@@Physionic Loved it too, would be interesting to hear about how taurine mechanically affects other parameters health parameters and exercise performance.

[@CHARSCREATEINCOMPANY]

I've been giving it to my dog for years for a healthier heart because they don't get enough especially in a grain free diet. I take it too. Good talk! 😊

[@jgfergus]

Grains don't have taurine.

[@Holy.HannaH]

Im definitely going to keep taking it.

[@Willy-hs7uu]

Same, I just take two1g capsules a day, I also eat a lot of meat and no energy drinks. also with NAC and Glycine.

[@ericmaclaurin8525]

Taurine and HMB work well for post workout pain as well. I notice a big difference if I take it in the morning and then also at noon.

[@presence5426]

Magnesium taurate has some interesting research published. Appears to benefit the CV system. If you take magnesium regularly, you can rotate between glycinate, taurate, and threonate to get various benefits.

[@georgecav]

What about Mg Orotate which apparently has a Particularly CV affinity according to Dr Ross Walker

[@BestCoachOnEarth]

I am back to magnesium citrate and take glycin and taurine seperately. Its easier to get the right dosages and much cheaper.

[@presence5426]

@@BestCoachOnEarth Good point. Citrate has a lot of research behind it too.

[@henrikmadsen2176]

@@presence5426• Do you guys know of a video explaining WHY the binding-substance create different effects ?? 🤷‍♂️🙏 (after all, the magnesium part is the same in them all).

[@presence5426]

@@henrikmadsen2176 I'd go to pubmed if you really want to understand that. A lot of these videos are by influencers or alleged experts, and I hear a lot of errors. I've seen claims about the absorbability of various mg supps. But the substance to which the mg is bound can certainly have effects. Take glycine: the most simple amino acid which can act as an inhibitory neurotransmitter. Shame youtube doesn't allow links. I'd send you right to a mg paper.

[@quand_meme]

Just keep in mind that taurine competes with beta alanine in absorption. And beta alanine besides its own health benefits, is the key factor for carnosine production. And this is the one of most important things for health and longevity. It for example removes advanced glycation end products from the body.

[@theancientsancients1769]

​@@paulpellico3797Taurine can Increase tumour size too

[@sheila7814]

As I am learning so much with my cancer diagnosis. Taking one thing causes problems in a different direction. Yes. Thank you for pointing that out. …… like taking anastrazole to make my body low in estrogen (because my cancer is supported by estrogen) it has caused my body to behave like diabetic… because now that I am low in estrogen and protected more from recurrence, the lack of estrogen affects my glucose management…. Because estrogen is part of the hormone process in regulating glucose. Grrrrrrr❤

[@jgfjfgjfhjf]

I do supplement taurine, 4g per day. Either all in one go before heavy exercising, or 2x 2g if I'm having an easy day. This is an absolute S tier supp, just like creatine. I'm 35 now (and not far from being in the best shape of my life, just after having a decade-long obesity episode), an frankly - it just makes my body work as if I were 23.

[@stevemarshall_uk]

Regular I use 3g morning, and 3g night

[@jgfjfgjfhjf]

​@@stevemarshall_uk I think I'll try more and see if there's any difference

[@EricAnimeFreak]

4-5g per day here, as well as 4g of creatine. 36 here, working on getting my first 100 miles cycling real soon, did 90 last month. I don't eat plants, carbs, or sugar with the exception of coffee with heavy cream.

[@jellybeanvinkler4878]

I lost 3 dogs while feeding grain free dog foods. This was over a 12 year period. And all spent months, if not years, on expensive heart meds and fluid removal treatments. It was a heartbreaking struggle for them, and me, though it kept my veterinarians happily content. I still feed grain free, buthave eliminated legume ingredients which I am suspicious of as a taurine blocker. I also supplement with fresh raw meat, freeze-dried meat/fish products, and canned mackeral and sardines.

[@jackbuaer3828]

It's hard to believe that your vets were happily content over the loss of your dogs. I doubt it. My dog is 17 (almost 18) and has never had a grain free diet. He gets home cooked food with vegetables, chicken, quinoa and corn and some supplements.. He is not a small dog. - 60 lbs. Unfortunately, I think he is near the end of his life though.

[@antonc81]

Don’t forget organ meats - liver, kidneys, hearts, tripe etc.. they’re an important part of a carnivorous animal’s diet in the wild.

[@larsnystrom6698]

Taurine is only in animal food. Nowadays they add it to cat food. Before that, cats got blind and had heart failure. Dogs can themselves produce some Taurine, so they aren't as affected as cats are. If non-animal dog food isn't supplemented with Taurine, you could add it yourself. Taurine powder is not expensive, and I don't think dogs would hate the taste. We humans tolerate the taste pretty well. It doesn't taste much at all. Half a gram a day, or so, should be enough to avoid actual deficency. Animal food can't give more than that, I would guess.

[@douglaslegvold9215]

@@jackbuaer382818 is a good life for a pooch

[@douglaslegvold9215]

@@larsnystrom6698bulk supplements

[@GlobalShutterNY]

Taurine is so safe and inexpensive - even a bit of value makes it a 'no-brainer' IMHO

[@theatreforesight]

Unfortunately, they don't know if it's safe or not. Recent speculation is that it could be one of reasons that colon cancer rates are sky rocking in young people.

[@Dan-dg9pi]

@@theatreforesight Are you referring to informed, scientific speculation or wacko conspiracy theory speculation? I would bet that 99% of young people have never even heard of taurine so it would be a surprise to me if that were the case.

[@FlemetAeton]

@@theatreforesight I'm looking on google scholar to find evidence of that and all I'm finding are a bunch of mechanistic studies showing taurine inhibits and attenuates colon cancer or induces apoptosis in colon cancer cells. There is one 2016 study reviewing bile acid conjugation claiming taurine conjugation has higher risk of harm than glycine conjugation that metabolize into some tumor promotor compounds.

[@Discostick55]

@@Dan-dg9pi it is added to energy drinks

[@Holy.HannaH]

It actually has a LOT of good effects on colon cancer. There happens to be a bacteria in the colon that seems to feed off of it though so younger folks who drink a lot of energy drinks containing Taurine essentially are throwing things out of balance for themselves by consuming things they dont actually need.

[@YotishAMV]

Fun info about Taurine. I like the blood pressure explanation. I think its really beneficial & you've hit this before but a person has improved taurine levels post exercise too. I didn't know about the minor blood sugar impact. That was my new favorite benefit to hear about. I'm still working reducing some sugars in my diet 😋

[@TheCabCabMan]

Look into berberine and cinnamon for blood sugar.

[@davidboufous4680]

Please more in-depth research on Taurine (especially its antifibrotic effect).

[@theancientsancients1769]

It increases tumour size

[@davidboufous4680]

Not true!...Taurine decreases the tumour size.

[@WaterspoutsOfTheDeep]

@@theancientsancients1769 taurine regulates calcium in the cell which is significant. cancer cells and dying cells have disregulation of calcium in the cell bringing in extra calcium it's a cellular toxin. this effect on it's own makes taurine a huge health supplement.

[@azdhan]

Great video. Many thanks for sharing bro! Hydrogen sulphide I have heard from others is strongly associated with colorectal cancer due to some mechanism assciated with a meat heavy diet and changes in gut microbiome makeup. I am not saying it is true of false, it was just something interesting given your reference to hydrogen sulphide. Also, one of the most prominent researches who brought taurine benefits to the public spotlight warns that further research is required to recommend the most optimal dose. He stated that theoretically ethnic and racial differences may factor into the most optimal dose on a case by case basis. He stated that would be an issue further future research based on availability of sufficient funding

[@akhileshp6419]

Just finished watching your taurine study video from an year ago, and see you've released a new taurine video lmao

[@michaelblacktree]

Thank you for taking the time to decipher this information for us. 👍

[@retired_man_about_town]

Love to see the deep dives.

[@ThomasAT86]

Great stuff, thank you!

[@MarioJosifovskiDev]

Taurine is a must supplement for cats, and cats are a must for happy life, just share youe taurine with your cats, it is a win-win. If you don’t have cats there is still chance for you to save your soul from eternal damnation. If you don’t have the space to keep a cat, feed street cats or donate to cat shelters.

[@burle1cm]

Meow! 😻

[@PeterCianci]

The same holds true for dogs; wouldn't want to keep those fury fellow friends out of the conversation😉

[@SuperPeanutTV]

Grain-free pet foods contain pea protein, which has been linked to cardiomyopathy, especially in dogs. It appears that pea protein is a major factor in causing taurine deficiency.

[@MarioJosifovskiDev]

@@SuperPeanutTV thanks for the info, i usually get meat based, but companies can be sneaky

[@123ChrisG]

@@SuperPeanutTVcan you provide some evidence for that? Thanks

[@fractalwalrus5409]

i cured my metabolic syndrome with Intermittent fasting, a healthy balanced diet, regular HITT exercise and a good nights sleep. i (permanently) lost 84lb over two years. A no brainer really... There are no shortcuts. Hard work pays. im 51. and now stronger and fitter than I've ever been.

[@PandaA-cv3mm]

That’s incredible and you should be extremely proud of yourself! 💪 🙌

[@belvederebaileycambodia]

it all evaporates at 55. Enjoy your last 4 years.

[@Eric3Frog]

@@belvederebaileycambodia😂 What’s your logic?

[@rshone99]

@@Eric3Frog You are always up against the clock but generally big declines only happen after 70 if you work at it and are a bit lucky as well. Check out the 100m sprint masters records, they have age groups and I find it interesting. I think there was an 80y.o. who ran a 14s 100m which is as fast as a lot of highschoolers.

[@fullalbums5675]

intermittent fasting is linked to a 91% higher risk of cardiovascular death, so while getting slimmer is good overall, better don't stay on fasting too long

[@Orygun]

Thank you so much for this!

[@Physionic]

You're so welcome!

[@livephysiology]

When results from a study show such little effect, it raises the question can the valuable effects of the treatment be found with other treatments? While a treatment may be mildly effective, it could be an already existing, sometimes cheaper or easier treatment can accomplish the same benefits.

[@openureyes]

Best explanation thank you

[@Physionic]

You are welcome!

[@sheila7814]

Yes…. I care…. Please go into more detail on the other areas you mentioned as well like diabetes and insulin resistance.

[@giovannigentile7211]

You convinced me to supplement with Taurine, being T2 and switched to only carnivore diet by already over 90 days with all the reported benefits! See you in a 6 months and I will have some evidences that your research is truly effective 😅 being a rapidly decaying 63 years old that looked always 20years younger 😢

[@bugsbunny4172]

Great info , thanks for sharing

[@roblim1767]

These results for a cheap supplement is impressive.

[@piccalillipit9211]

*ANECDOTAL* I started supplementing with Taurine as it's indicated to help with long covid [which I have] - I noticed an improvement in muscle mass and a reduction in body fat of about 3kg As I can do NO exercise and have a strict diet I know this was the only change I made. The difference in muscle mass and tone was quite noticeable.

[@fullalbums5675]

sure

[@piccalillipit9211]

@diamondSunDNA No true. Thats Bro science not actual science. If Taurine is the limiting amino acid preventing you from putting on muscle mass then supplementing with touring will increase muscle mass.

[@douglaslegvold9215]

Can’t wait for a video on HMB affects for the aging.

[@jorn-michaelbartels9386]

At least, in combination with a few cups of coffee, taurine enhances the performance for work in the morning. It’s great, if a supplementation has visible effects!

[@stefanweilhartner4415]

my 2 cents: i saw a study about the mechanistic function as a pH buffer in mitochondria that showed the speed of beta oxidation dependent on the pH environment in the shape of a sigmoid function. and taurine acting as a pH buffer combats the pH level in the mitochondria to get too acidic too soon in a bit higher exercise intensities. understanding that mechanistic effect means that a lower triglyceride level sounds logical. interestingly we know different buffers and together it makes sense as a chain. taurine in the mitochondria, carnosine in the cell and bicarbonate in the blood.

[@burle1cm]

My 2 cents: Your comment would be much easier to read if you capitalized the first letter of each sentence. ☮️

[@theancientsancients1769]

Taurine increases tumor size

[@stefanweilhartner4415]

@@theancientsancients1769 so does food. correlation or causation? study?

[@markeby3636]

I also like when you get into the technical aspects, like Eric777. Keep up the good work!

[@Physionic]

Thanks Mark!

[@andrewtaylor9799]

Good information.

[@LesleyPeach]

Hydrogen Sulfide is highly toxic, and it makes sense that the blood vessels should open up when hydrogen sulfide levels are elevated. Higher oxygen levels would be expected to decrease to level of hydrogen sulfide (the most reduced form of sulphur) by allowing the sulphur to be oxidised to sulphate, which is not harmful at low concentrations.

[@peterz53]

Thanks for details

[@Physionic]

Thanks for caring :)

[@amarug]

Can I infer from this that there is a possibility that Taurine could also potentially support the suppression of some types of arrhythmias, since the hyper-polarisation of the smooth muscle cells could elevate the threshold and make noise in the electrical pulses less likely to activate trigger the flutters, extrasystoles etc?

[@brandongreen1177]

Thanks for the content :-)

[@swenic]

1:45 You are incorrect and it is common to confuse hydraulic speed with pressure when reducing the diameter of the tube. When squeezing the end of a water hose the water will fly further because of the higher speed.

[@chamuuemura5314]

3:20 taught me that many nay sayers aren’t negative people they’re just hyper polarized.

[@MildlyLinguistic]

Great video as usual. Just wanna note that ever since you changed your audio setup, it seems like the volume's gone down quite a bit and, at least for me, I have to max out both my system and video player volume to just barely get it to what I feel is a decent level (though still not my preferred level).

[@Physionic]

I can only make it a little louder before the audio starts to clip on my end, but I'll see what I can do - thanks

[@InHellBaby1]

Volume seems normal to me.

[@AJDelanoue-tb9vo]

Im just on a phone and max volume is too loud, so have you looked into hearing loss from your system?

[@aldarund]

@@AJDelanoue-tb9vo no, volume certainly way lower than other youtube videos, for example open any RP video vs this one

[@AJDelanoue-tb9vo]

@@aldarund the point still remains that the video is able to be played above desirable levels on a simple phone. Get checked out if ur having issues hearing it lol

[@isa-manuelaalbrecht2951]

2 grams daily helped me to overcome eyefloaters...entre- autre...😊

[@fullalbums5675]

they probably just moved out of sight

[@Moni-ui5bz]

I've been taking 2gr daily for over a year and my floaters are still there, very annoyingly so.

[@isa-manuelaalbrecht2951]

@@Moni-ui5bz do you also add vits and minerals and Omega 3 ?!?

[@Moni-ui5bz]

@@isa-manuelaalbrecht2951 I take supplements that supposedly help with eye health and I think they work since my eyes are healthy, but the floaters. I don't take omaga-3 anymore since most of those supplements are rancid. I do however eat sardines in water 5 days a week. I do IF, and eat no processed food, no grains and no seed oils.

[@justicemcrae6005]

What freaked me out was the picture on the wall, was it in your home or office , but good study report

[@baseballfan172]

W bro! This was very interesting but to clarify… take taurine and if so, what dose? Thank you!

[@larsnystrom6698]

1 to 6 g a day seems to be doing something, and usually without any side effects. We can get perhaps 1 g from animal food. But more than that is expected to be optimal. When young, you might produce enough of it, but that's diminished with age. The rat experiments that increased healthspan and lifespan utilized more than corresponding to those 6 g. But they didn't try to find out if a lower dose would do the same.

[@DCGreenZone]

Started 1g/day about a month and a half ago, melatonin production also drops to near zero by age 70, as does glutathione. Mg and D3 deficiency is rampant in the GP, Liposomal D3/K2 is out there.

[@derrickbyal8462]

Im not understanding why you need to supplement if you're eating meat at each meal? And would you not have to take away from meals?

[@jenxsj3902]

You are so clever ❤.

[@RickNuthman]

So what is the recommended daily dose for benefits?

[@belvederebaileycambodia]

chatgpt is your friend

[@RickNuthman]

@@belvederebaileycambodia please don't use a llm to make critical health decisions

[@Alex-wg1mb]

Starting from 20 years old consume 1 gram. With every decade ontop add +1g of Taurine. This is only regarding the supplement form. Regarding food it is advisable to get 5 grams of it every singe day.

[@archmaesterofpullups]

The impact on LDL-C is pretty high; it's probably the best natural supplement for lipids. I usually recommended either 5g/day if taking one bolus dose or, optimally, 3g TID.

[@Orygun]

Liked and subscribed

[@marcelludovici4009]

Upregulated TUG 1in colonca, Taurinconsumtion in Energy drinks and colon carcinoma, not clear until now if this could be a negative side effect I guess

[@augustmosco]

Thanks Nick---this was good. I'm no biochemist, so your laymen's explanations are really helpful. Question...have you ever investigated SHBG and its effects on free testosterone? I'd be very interested in your thoughts and finding on this subject. Especially, how to manipulate through diet and lifestyle. Thanks again.

[@Physionic]

Thanks - yea, I have. SHBG drops free testosterone. It's part of a three compartment testosterone model - free, bound, 'moderately' bound (to albumin, I believe, but don't quote me on that). SHBG seems to be locked, so there's nothing to do with that one, but the other two can be bioavailable (especially free, considering it is bioavailable).

[@drscott1]

I suspect the age of the subject is important on the effect of the supplement

[@Physionic]

I think so, too

[@jwstolk]

Natural taurine levels are known to decrease significantly with age, but the decrease is very gradual, it basically starts decreasing after we are born.

[@drscott1]

@@jwstolk I am thinking that older persons will see more benefit

[@soultox]

@Physionic ... Nic, does taking Taurine close to or with Glycine reduces the Taurine absorption? I read somewhere that Glycin is using the same trasporter or something like that!? Do you know anything about this?

[@Physionic]

I haven't run across that, but that doesn't mean it can't be true. I probably wouldn't worry too much about it.

[@Holy.HannaH]

It also reduces serine and threonine. However, from my understanding, it seems to be isolated to certain muscle groups rather than a lack of absorption in the entire body, and it seems to be beneficial. We likely need more studies but thus far it seems like this is part of the beneficial effects of Taurine during exercise .

[@soultox]

@@Holy.HannaH Can you share the article or resource to the paper talking about it? I take my glycine in coffee that I drink through the day and take taurine 3 times a day 2g per serving.

[@Holy.HannaH]

@@soultox I don't think I can post a link here but here's the title, date of publication, and some ID numbers. PMCID: PMC3761861 PMID: 24149876 June 2011 "Effect of Taurine Supplementation on the Alterations in Amino Acid Content in Skeletal Muscle with Exercise in Rat" There may have been more studies since then that examined this further, I'm not sure. There is definitely information out there regarding the benefits of them working together. Personally, I think your method/routine sounds fine. Only thing I can add is that, if I remember correctly, Taurine seems to have a better affect when it is NOT taken on a regular schedule, though I cant recall the mechanics behind that at the moment.

[@larsnystrom6698]

I ignore the effect of amino acids blocking each other. My working hypothesis is that they all will be absorbed eventually. It's so impractical to do anything else! The inference effect is there, but does it really matter? I actually mix taurine in whey and collagen, compleatly ignoring amino acid uptake inference!

[@gabriellew6467]

Interesting - taurine has been touted as useful for the heart and for eyes (improving retinal synaptic connection), further investigation might be useful. Ok, this is a startling image: Dr Verhoeven squealing. Accompanied by a hop, a skip and a jump? 🤔

[@fsalam]

I guess the studies included non metabolically impaired subjects too, which may have skewed the results and a better efficacy can be implied for those metabolically impaired? Different dosages were apparently used by different studies, so what should be dosage to start? Try 3g a day and see the results rather than agonise over dose since it is cheap and safe?

[@jameskelly6479]

I think your levity improved the effects of taurine.

[@hammersaw3135]

it is very relaxing, I take it at night, it is better than a lot of amino acid supplements, probably the best.

[@chrislee176]

‘The jury will disregard that last statement’. 😂

[@Annapurna818]

Insulin goes sky high with fasting. 😢 Fatty liver and metabolic syndrome. Help.

[@Manweor]

I started taking magnesium taurare instead of the usual citrate. Will it help?

[@rodrigsantsil]

I've been taking it for 2 weeks now and my triglycerides sit at around 48 I wonder whether it'll pose any health risks if it hits 30

[@saliksayyar9793]

Dose is the issue. How much? Study difference due to dose and age ?

[@cookim3899]

Which product to buy ?

[@maxnova9763]

Maybe that’s why I’m so addicted to Red Bull Zero

[@larsnystrom6698]

When they do Taurine clinical trials, do they use L--Taurine? That's seldom mentioned, as far as I've seen. Do we know if that makes a difference? Taurine seems to work by pretty subtile mechanisms, such as osmosis in multicellular organisms, and changing the environment of enzyme reactions. No one seems to dare exploring that!

[@callmeishmael3031]

I’m currently curious about what I’ve heard are the benefits of taurine supplementation for eye health.

[@MrAZemitis]

There is a study that it is linked to cataract progression

[@Name-zd5fq]

Helps me with my arrhythmia.

[@huaytita]

Which one have you got? What dose do you take?

[@Name-zd5fq]

@@huaytita I have used capsules for years. Recently I started mixing some powder into my coffee. I take about 2000 mg a day.

[@JasonBuckman]

When to take the daily taurine? Spread throughout the day? All at once (at wakeup, mid-day, or before bed?)? With food? Fasted on an empty stomach?

[@besanit]

I take it in the morning with my coffee (home brew red bull), its tasteless so you can add it to anything.

[@jwstolk]

Unlike most other supplements, taurine seems to work better on an empty stomach.

[@nattydred2593]

So that's what "sensitivity analysis" is! Cool.

[@trollmcclure1884]

Many people say it helps them with heart palpitations. A lot of good anecdotal reviews on certain sites that pop up when you search for a compound or a herb. I cant write the site here for anti-spam reasons but it's not hard to find

[@BMulligans]

Exercise is actually the saviour

[@DF-de8ib]

@@BMulligans It is. Taurine and glutathione improves after exercise.

[@0177Mia]

WHICH brand has the "purest" for beneficial results? I take this daily, *over 6 months* however, perhaps the brand (or the results) has been stagnate, or my body isn't absorbing it. How can you tell? I use a B-complex, taurine 2kmg, 1tsp apple peel powder and acerola 1/5tsp in water 8oz (is this power drink mix too much?)

[@supercal333]

Does taurine need to be fully dissolved when taking it or can i dry scoop it and chase with water?

[@ogungou9]

(What about taurine and cognition? It should be interesting).

[@larsnystrom6698]

It has an effect on memory, so probably on cognition too. I think he mentioned that for fruit flies. So if you are one of those,... 🙂

[@baarbacoa]

I started taking 2g taurine daily, but eventually found that it relaxes me to the point I become sleepy and unambitious. So I take a much lower dose now (~100mg).

[@Eric3Frog]

Why not take a larger dose before bed?

[@ginz9r]

Did you take it with food?

[@JC-ce1mk]

yes, take at bedtime. I do!

[@DebLeeMn]

Why do some take Taurine for energy, but others say it helps calm them and helps them to sleep better?

[@agustinbonforte5608]

supplementing taurine among with esential aminoacids could diminish de bioavailability of taurine and its effects?

[@xsix16]

probably been asked before, but the painting jn the background, I love it, where does it come from

[@supercal333]

I don't think it's a painting. It looks like a blown up photograph of some kind of cellular structure.

[@MrJohnson57]

So how much Taurine is being ingested in these studies? I take two grams per day, and I don't feel any difference.

[@jwstolk]

It is mentioned in the video: 0.5 to 6 grams/day. I take 3g/day, divided over early morning and late evening. I don't notice any difference but also take other supplements, so I would have to do some testing to figure out if specifically the taurine has any noticeable effects. There are only limited studies about taurine for now, but a few grams a day does not seam to have any clear negative side effects.

[@MrJohnson57]

@@jwstolk Thank you

[@supercal333]

You don't judge supplement efficacy by 'noticing a difference' over the short term. You just have to trust the studies if they are high quality.

[@levprotter1231]

The way I see it, the blood sugar data should be disregarded, since it doesn’t tell you much about metabolic syndrome directly. The triglycerides are more interesting because they are likely more relevant for the etiology of metabolic syndrome. Plenty of amino acids can change your blood sugar acutely at least, but that really doesn’t tell you much about health effects.

[@JesusGarcia-Digem]

Any studies on Rhodiola Rosea?!

[@usd2868]

My mama has high bp and dad has low Should I give them both taurine

[@Miroslaw-rs8ip]

But how much Taurine do you have to take to reduce HBP? I take 3 capsules a day equivalent to 2 grams and still have HBP and take daily medication.

[@rosietheriveter107]

Are you serious? You are ignorantly trying to treat real hypertension with some supplement? Go to your doctor and listen to his recommendations. Wow!

[@GloriaCote-o1c]

And...nice guns, Nic.

[@jason5265]

I can’t take Taurine bc it makes my feet hurt like pins and needles. When researching AE, I found nothing on it. I’ve tried Taurine 3 times and 3 times I’ve had the same problem

[@Dzazter]

Anyone has a recommendation for a good Taurine brand?

[@maestroharmony343]

I wonder how Taurine benefits overlap with NAC. Both molecules contain sulfur. (And yes, MSM, too.)

[@Physionic]

Excellent question - there might be some overlap, but the mechanisms of glycine and cysteine are a bit different biochemistry

[@larsnystrom6698]

And MSM too! It's more sulphor in those supplements than we usually get from food. But I've no idea of what it does to us, if anything. I would like to know that too!

[@MrAZemitis]

@@larsnystrom6698 Taurine is made from cysteine witch is a component of N-Acetyl-Cysteine. Probably if you take taurine more cysteine is available in the body for the synthesis of glutathione

[@man_at_the_end_of_time]

​@@larsnystrom6698MSM is powerful for this man. It helps with muscle soreness due to exercise and it really profoundly helps with seasonal rhinitis.

[@stevenluitjens1348]

Could you talk about Phosphatidylserine?

[@privateerburrows]

Everything you are saying about hydrogen sulfide rhymes with the story of nitric oxide; are you sure you haven't mixed them up? I always thought of hydrogen sulfide as a poisonous gas.

[@Physionic]

Not unless the researchers misspelled it about 100 times. :)

[@privateerburrows]

@@Physionic So, this must be why I smell like rotten eggs ... TOO MUCH taurine ...