Breaking Bad: 5 Crucial Differences between Amphetamine vs. Methamphetamine | Exploring the Impact

Welcome to Psychiatry Simplified.
Have you ever pondered over the distinct disparities between amphetamine and methamphetamine and their intricate repercussions on the human body?
Key points in the video:
00:00: Exploring the Core Differences: How do amphetamine and methamphetamine bring about distinct effects within the body?
02:04: Structural Uniqueness: Discover the specific characteristic that sets methamphetamine apart from its counterpart, amphetamine.
04:07: Balancing Risk and Benefit: Understanding the link between the speed of action and bioavailability of methamphetamine and how it contrasts with the safety profile of amphetamine.
06:03: Dosage Insights: Unveiling the typical dosage ranges associated with methamphetamine usage.
07:44: Neurochemical Mysteries: Delve into the complex pharmacological impact of methamphetamine and amphetamine on the brain while deciphering why methamphetamine's allure lies in its heightened euphoria and addictive nature.
If so, brace yourself for an enthralling expedition as we explore the very essence that sets these two compounds apart.
Join me, Sanil Rege, a consultant psychiatrist, on this episode of "Psychiatry Simplified," where we unravel the multifaceted distinctions between amphetamine and methamphetamine.
Amphetamine and methamphetamine, two potent stimulants, possess intriguingly diverse chemical compositions and wield varying influences on our bodies.
As we delve into the heart of this video, we will intricately dissect five pivotal differentiators between amphetamine and methamphetamine.
From their unique chemical structures to their contrasting routes of administration, potency levels, effects on the central nervous system, and long-term health implications, we will navigate through this intricate maze to illuminate the distinct risks associated with methamphetamine usage.
Methamphetamine, in particular, has earned its reputation as a ticking time bomb due to its highly addictive nature and its potential to inflict profound physical and mental harm on its users. Its potent euphoric effects can swiftly transform into a destructive addiction, unleashing a cascade of behavioural, psychological, and physiological challenges. Our exploration will provide insight into why methamphetamine poses such a significant peril to individuals and communities alike.
Moreover, we will plunge into the dramatically dangerous territory that methamphetamine treads. From its devastating impact on brain function and cognitive faculties to its capacity to catalyse violence and criminal behaviour, this substance stands as a menacing force that demands our understanding and attention.
Don't forget to show your support by liking, commenting, and subscribing to our channel.
#AmphetamineVsMethamphetamine #TickingTimeBomb #PerilousImpact #DrugAwareness #AddictionInsights #HealthEmpowerment #PsychiatrySimplified #SanilRegeMD #DrugEducation
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[@dalebronniman9060]

Decades ago,I took a matched size snort,small amount,went to work 3 days ,ironwork,broke the headboard on my bed with my wife 3 nights,absolute wild man,4th day finally back to normal.

[@willtreblar]

yup, doesnt take alot at first, but after 20 years of use....

[@kimandkyle420tyer6]

You talking about a Benny? Benzadrine inhaler

[@kimandkyle420tyer6]

Lol😅

[@huemann7637]

It was that good dextro rotary speed made by reductive amination of pseudoephedrine with red phosphorous in hydriodic acid. 👌

[@user-oi5pn8gb6i]

Meth makes me an animal in the bedroom rivaling John Holmes

[@mischahowell5775]

In my professional experience working with addicts and lived experience, psychiatrists are seeing significant progress and lower rates of relapse by prescribing dexamphetamine/ dextroamphetamine to patients with history of methamphetamine abuse/ addiction because of the similar chemical makeup. Harm reduction works.

[@PsychiatrySimplified]

Thanks for sharing. Good point

[@KlausSchwab-uq9sl]

this is so true i learned the hard way

[@substance9x]

ii hate everything about meth i have tried it maybe 6 times, only one time was it remotely enjoyable -= stay away!

[@RomanShein1978]

@@substance9x Amphetamines are great performance enhancers. They are for work, not for joy. Although under the influence you may enjoy the work more.

[@RomanShein1978]

At small doses, they are absolutely the same, no difference whatsoever.

[@chanvalentine8283]

Okay, that explains why in the 70s,using the Vicks inhalers, made me more alert.

[@187lynne]

We couldn't afford the name brand Vic's we had to use the green mentholatum jar😂

[@Briankatzen]

levmetamfetamine (the spelling is correct) is the active ingredient in generic inhalers which are still available at Dollar General, Meijer, CVS Pharmacy and Walgreens. Vick's inhalers are now non-medicated. It's levo-methamphetamine, the weaker "left handed" isomer.

[@DingDongDaddyFromDumas]

The amount of L-meth you’d be exposed to via a nasal inhaler wouldn’t have any effect on you psychologically. It’s just there as a local vasoconstrictor.

[@jadwilliamz2304]

Yeah the reaction is just meth driving you wild, I'd punch ciggys and billys to get heart rate up....in addiction just thinking about scoring did the same

[@chrisbrent7487]

l-methamphetamine is barely active as a stimulant. All the activity in that regard is with the dextro isomer. Levomethamphetamine is just there as it is used as a vasoconstrictor the same way that ephedrine isomers are in cold tablets.

[@haymaker710]

I never knew those Vicks inhalers I used as a kid had meth in them.

[@PurpleGold.]

As a 50 year old female whose only discovered that I have ADHD, this video is GOLD! Subscribed straight away. Love how you make it so easy to understand.

[@PsychiatrySimplified]

Thank you 🙏🏻

[@djquinn11]

I’m 60 and have known I have ADHD but haven’t been diagnosed yet. I started on Wellbutrin 4 months ago for depression which has helped with the ADHD a bit but have been curious if Adderall would help even more. This video is very informative, thank you so much.

[@symbolsarenotreality4595]

@@djquinn11 good luck with that tripper

[@chipsramek3868]

@@djquinn11 ... Wellbutrin is Very addictive and ADDERALL is not ... hope that helps ... plus the side effects with Wellbutrin suck.

[@housemana]

@@chipsramek3868 whoaaa there bud. amps are demonstrably high risk to most addictive types. jfc the goofballs on the internet just so weird

[@shawnrobertson9901]

Methamphetamine and amphetamine psychosis is a product of lack of sleep and not due to any inherent properties of the substance. This effect can be seen in patients that deal with insomnia. This should be referred to as sleep deprivation psychosis. The psychosis will subside after regular sleep cycles resume. It takes anywhere from 24 to 72 hours without sleep to start noticing reduced mental function. Cases of insomnia rarely last more than a week but insomnia caused by drug use can go on for weeks or even months with further mental deterioration. People with longer lasting insomnia that is not caused by substance use will also experience similar mental deterioration. There are likely residual effects over time in both cases. This is a case where correlation doesn't equal causation. Failure to acknowledge or study this common link is a disservice to the scientific method.

[@PsychiatrySimplified]

It is due to the inherent property to release a significant level of DA , NA & Serotonin. These directly impact sleep as the sleep milieu requires at various stages a complete silencing of NA DA & 5HT. Severe insomnia is part of agitation and is a risk factor for psychosis. But Methamphetamine directly increases DA significantly which results in aberrant salience - the salience network is responsible for the genesis of psychosis. This is also the reason why a D2 antagonist treats the psychosis. One can’t simply say that psychosis is due to sleep deprivation only. We see several patients who are sleeping feasibly ok that can have relapse of psychosis post use.

[@jeffamb]

not true,

[@ShardulIyer]

​​@@PsychiatrySimplifiedexactly, this is also seen lot more in flakka which is like methamphetamine. Since flakka likely overloads the nervous system lot more than meth, the psychosis from flakka is almost always 30mins later with D2 dopaminergic receptors overload. Having said that, you said it right that it's never simple & whether it's flakka or meth, dose and biochemistry play huge role. In addition, it's true that stimulants especially amphetamines usage even in ww2 has insomnia & thus acute sleep deprivation is observed in various people leading to cognitive decline but this too is dependent upon stress and environmental issues. Thus no wonder that a war like situation coupled with amphetamines might lead to higher psychosis rate but this alone doesn't mean that amphetamines alone lead to psychosis yet amphetamines (especially unregulated street ones) may also trigger psychosis in compactible individuals especially those with schizophrenia/bipolar history or worse cause perception distortion syndromes.

[@fightington]

​@@PsychiatrySimplifiedi dont want to convolute things but how does that neurochemistry relate to psychosis purely bor of sleep deprivation - point is i think you and OP are correct - further and concerningly, it's prob sone rough overlapping negative feedback loops ie. drug induced psychosis as you suggest - result is inability to sleep - skeep deprivstion induced psychosis - fear response etc making it harder to sleep - SD pyschosis - take more drugs to stay awake - DI psychosis Its not about right and wrong answers - its about both are correct but partial, heres how they fit and here is more to add to the infinite picture Integral Medicine is putting these things together - Ken wilber has the underlying model and it can be apllied to all fields and then integrate those also

[@user-dy2ql6hq8p]

I don't agree with that. I am sorry but through personal experience, I have seen those people that have slept and as soon as they intake the drug they immediately start seeing and hearing things that are not there. I do agree there are those that do start having the effects once they have lost many hours of sleep. Someone without drug use can see and hear things after so many hours of no sleep. However, there are the ones that have them from intake.

[@nathanashley2693]

its seems that the addition of a methly group to the amphetamine molecule effectively doubles the potency, this is very similar to the what happens with the methylation of morphine to heroin where the addition of the methly group effectively doubles the potency of morphine.

[@antitheziz717]

Morphine is acetylated to heroin.

[@chemistryofquestionablequa6252]

Methyl morphine is codeine which is orders of magnitude weaker than morphine, whereas diacetylmorphine is heroin and approximately 6x stronger.

[@chupacabra304]

@@antitheziz717diacetyl-morphine yup!!

[@ShannonDove-sy7ye]

Yep. The Bayer pharmaceutical company used to love adding acetyl groups to stuff. Aspirin is salicylic acid with acetyl groups added. They claimed that this acetyl group made morphine much less addictive, lol

[@timothylevin2661]

It increases the speed across the blood brain barrier

[@gravestoner420]

My dad had a meth addiction for 20+ years. My mom too. When I was 12 I developed an addiction to amphetamine adderall pills. I didn’t even know what it was or that they were even related until 2 more years in and than finally quitting at 16.

[@LetArtsLive]

My son was 5 years old when they started giving him those sort of pills I was afraid to take them off of them because I was being watched by CPS because their mother screwed up not cuz I did.. they lived with me a doctor who did not know my son saw him for 1 hour.. well I don't do drugs but one time I know its speed and I went to a Ozzfest I took one of those pills... well on the way we went to my friend's house we were smoking weed and drinking and we got there right before Ozzy came on and I was still so wide awake even after I went home at 3:00 in the morning I still couldn't sleep and they were years old then cuz I took him off of them and I can't even take them ever they are 20 years old I took one a couple summers ago I was awake for a whole day so if it does that to an adult what does it do to your child?? And then later in life Daniel Junior got Adderall back then he started doing crystal meth and I don't think he died from that I think it was the drug dealer but I will never know cuz nobody cared at the Batavia New York Police Department they said they assume he died from drugs.... that's what these drugs can do for your kids and it's not just me my friends kids we're on that kind of medicine and they started going off when they took them off at the age of 18 doing drugs I think it makes you an addict.. I already know I'm an addict but I don't do drugs and when I did the rock it was for one day and I hated myself... and unlike what they tell you it's not exactly wonderful for your sex life either if you're a guy anyway I don't know about women?? If a kid goes in and they're hyperactive or something they get them addicted to this s*** that's where it is f****** garbage excuse my French but I freaking don't like what it did to my son he's gone forever and I hate myself for not being able to save him everyday I called him you got to stop doing that you're going to die and he did.. I have one leg now I called my son Jimmy I said I haven't heard from Daniel can you go check on him while he was dead that's what these drugs can do for you and I'm thinking the Cymbalta to make me happy and the Seroquel to make me sleep and the Vicodin is in helping me either I think cannabis helps me more and gummy bears 50 mg CBD but they don't want you to know it can help people they want you on the f***** up drugs.. I'm 62 years old I drank for 20 years wasted my life away and now I have nothing really and I quit drinking a lot when I was 38 and had children.... well it keeps me from drinking to know I can drink someday but I get in trouble so I Drink Alone just like George Thorogood LOL there's a song I Drink Alone cuz I can only stand to be by myself but the reason I wrote this if it helps anyone it is good...

[@joseph-mariopelerin7028]

i can relate to that... be careful out there it's a mad world... idk how old you are now, but that shit leave a trail... it can be hard not to go back in the trail when lost...

[@chipsramek3868]

Nice Try ... Do You work for MOSSAD/CIA/MI6/GIP or the UN ? ADDERALL is NOT Addictive.

[@joseph-mariopelerin7028]

@chipsramek3868... yeah ok... by how much sense you make, that gives the idea...

[@bricebowlin8834]

Adderall is not addictive? Bullshit I don't buy that for a second. Anything done in excess for extended period is addictive​@@chipsramek3868

[@Undersymphonoflife]

If snorted, the on set time of both meth and amphetamine are very close to each other if not exactly the same, same goes with intravascular use.

[@KlausSchwab-uq9sl]

yup its intravenous by the way

[@Sniperboy5551]

Most people smoke meth, which results in a very rapid onset. Kind of like how crack is more addictive than cocaine, the time to peak blood concentration is what’s responsible for the “rush.”

[@KlausSchwab-uq9sl]

@@Sniperboy5551 i know its very addictive im glad its not around as much were i live. i instantly liked it smoked a couple of times but im amphetaminefree now thank God

[@dant.3505]

Back in the day IV was the ONLY way to for meth or crank.

[@KlausSchwab-uq9sl]

@@dant.3505 the flash ;)

[@RubenDuate]

I started doing drugs since my teenage. Got addicted to fentanyl for over 6 years. Fentanyl addiction actually destroyed my life. I suffered severe depression and mental disorder. Not until my mom recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 2 years totally clean. Never thought I would be saying this about mushrooms.

[@SharonFalcon-fj7nb]

Congrats on your recovery. Most persons never realizes psilocybin can be used as a miracle medication to save lives. Years back i wrote an entire essay about psychedelics. they saved you from death bud, lets be honest here

[@nicholda436]

I've been looking to try shrooms for depression, just very difficult to get a reliable source here in Australia. Really need!

[@mattjeffery09]

YES very sure of Dr.medshrooms. I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.

[@laurj09]

Ive done shrooms last month in my house. It taught me how severely traumatized I was from alcohol. I healed from many mental traumas from my past and was able to forgive, let go. Shrooms to me is a remedy not a vice. I even felt more refreshed the morning after. So no hangovers. No depression mood for days. No anxiety.I now have a more calm mind

[@FredaMartins]

How do i reach out to him? Is he on Instagram

[@clintparsons3989]

Vicks inhalers still contain levomethamphetamine. It’s just labeled as levmetamfetamine.

[@KlausSchwab-uq9sl]

yep

[@Sniperboy5551]

Yes, but it doesn’t get you high. It just makes you jittery.

[@sotiify9221]

@@Sniperboy5551 because its in its purest form

[@RomanShein1978]

@@sotiify9221 because its in its purest form - On the contrary, it is pure L-enantiomer, with all R-meth being removed.

[@jdjones4825]

A gram of amphetamine, some lsd and a vix stick got a lot of over 40 year olds through many a night of dancing..

[@vilaland2024]

"If I found this video useful"?? Sir I got angry at the end of the video because it was the end and I was enjoying the vivid information you were clarifying

[@PsychiatrySimplified]

Sorry! 😀. We have a range of other videos and more coming up that you should find useful. But can’t guarantee you won’t feel angry at the end ☺️

[@LifeGlitch1]

If you stack Amphetamines with Tropoflavin and low dose Selegiline and Memantine, there's no neurotoxicity or excitotoxicity. Also, you can cycle Amphetamine, Methamphetamine, and Ethylamphetamine with Modafinil and Adipex. And if you want to quit amphetamine or methamphetamine, use Kratom and Khat plants. Propranolol helps to not use alcohol all the time.

[@Jennifer-bw7ku]

Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.

[@APOLLINAIREBARTHOLOMIEU]

Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Australia. Really need!

[@steceymorgan814]

Yes, dr.sporessss I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.

[@IkamiLog]

I wish they were readily available in my place. Microdosing was my next plan of care for my husband. He is 59 & has so many mental health issues plus probable CTE & a TBI that left him in a coma 8 days. It's too late now I had to get a TPO as he's 6'6 300+ pound homicidal maniac. He's constantly talking about killing someone. He's violent. Anyone reading this Familiar w/ BPD know if it is common for an obsession with violence.

[@APOLLINAIREBARTHOLOMIEU]

Is he on instagram?

[@steceymorgan814]

Yes he is. dr.sporessss

[@quietlightning4063]

Simple answer is that Methamphetamine is orders of magnitude more powerful than the Amphetamines.

[@theresamorris6206]

Such good information. An very well presented too . Thank you. Much 💕 & always stay safe out there now !

[@PsychiatrySimplified]

Thank you

[@finnjuniperdenaro]

Great Video mate :) I subscribed to your channel because you offer brave, honest, polished insights. I appreciate your work. ✊💛🌟

[@PsychiatrySimplified]

Thanks for the sub!

[@ryancafferty4973]

brave? lol you sir are bot

[@commentsedited]

This just popped up but. Dude. You have the right look for a video of this type

[@PsychiatrySimplified]

🤣

[@carwashadamcooper1538]

Yup. Those eyes say a whole lot!

[@jennifermoody6987]

​@@carwashadamcooper1538lmao!! THIS is the comment I've been scrolling for ages to find because I said the EXACT same thing!!🤣🤣😂😂😆😆😉😉😳😳👀👀💯💯💀💀🤦‍♀️🤦‍♀️👏👏

[@procactus9109]

The right look.... Just lol because that's obviously the credentials required to make videos, right ?

[@mojolojo8605]

You can look like that if slam liquid courage all the time as well. It's all lack of sleep

[@chriscann3824]

Informative and interesting. Thanks 🙏

[@PsychiatrySimplified]

Glad you enjoyed it!

[@pezz2345]

I have been looking for an explanation to this forever thank you so much!!!

[@PsychiatrySimplified]

Welcome

[@DavidMccallister65]

I wonder how many of the doctors, chemists or psychiatrists have actually tried both of these drugs. As someone that has taken both on several different occasions, I can tell you that there are no noticeable distinctions between the two highs. They're identical. The only real difference that I may have noticed was that methamphetamine felt a bit dirtier or not as pure as the Adderall or generic brand which was simply labeled as "Amphetamine".

[@nochpeps8601]

Bullshit. Meth is like a thousand time stronger. Also used both.

[@dxxdmxn1010]

you're not really going to FEEL a difference. most stimulants, still give the "same high" really when it comes down to it. it's like cocaine and meth. they're pretty similar, meth just last much longer and is much cheaper

[@DavidMccallister65]

@@dxxdmxn1010 I disagree. I've done them all including bath salts and I definitely felt differences between them. Although, yes they're all stimulants but they still had slight differences. Crack was a short but powerful rush. Powder cocaine, depending on the quality was shorter acting and less intense. Meth, again depending on purity is intense and LONG lasting but comes with more paranoia and makes the thought of eating nauseating and leaves you feeling very unclean and contaminated. Adderall always gave the same feeling as meth. It took longer to take effect but then it was the same long lasting high that made eating and sleeping impossible. It still left me feeling dirty but maybe the thought of it being "cleaner" was just in my head because I knew it came from a lab rather than some Mexican's bathtub lol

[@tokoti9025]

ive done caffine, ritalin, coke, meth, and adderall. basically in my mind ritalin is like super strong caffine or like a shitty coke buzz imo. meth and addy r super simular from what i remember, 2 differences were that meth had more of a rush and horrible psychosis after 8 hours@@dxxdmxn1010

[@lilbattybaby]

I’ve also taken both on several different occasions and I have to disagree. I do have pretty severe adhd, but I have never experienced a meth level euphoria on adderall.

[@melody3741]

As someone involved with this stuff, psychosis I’ve seen has nearly always been triggered by a lack of sleep.

[@mvsmvs8428]

yep lol got to sleep and eat or you get into trouble

[@evonne315]

Exactly lack of sleep is like taking drugs on its own.

[@silvertone1]

You guys can't trell me hearing voices isn't cool. I get this deep robotic voice issuing non-stop comnands but I can't make out what its saying.

[@melody3741]

@@silvertone1 you have a very good point but unfortunately the social climate in the country I live in means nearly all psychosis turns into paranoia and panic

[@robertmiller6822]

​@@silvertone1that's psychosis dude I used to take all kinds of drugs and I took mdma for awhile and heard voices for awhile when my brain would shut down for sleep, it ended up going away after a year or so, was on herion and every other drug for 15 years been clean like 12 years.

[@curtiscarlson8958]

Great information. Very helpful.

[@PsychiatrySimplified]

Thanks

[@jaredvalentine144]

Super informative!! 😁 Thanks for all the insight.. Could you please do an episode on MDMA next. Thanks 🙏🏻

[@PsychiatrySimplified]

I will keep it on the list.

[@l-esprit_de_l-ouest]

@@PsychiatrySimplified mdma and the mesephetamines witch are often mixed with mdma in pills and can kill easyly naïve consummers. And why people should use only pure mdma rather than pills.

[@mikeythearchangel]

For whatever it’s worth I subscribed at 0:32 Very impressed already Thank you for this ❤🎉

[@PsychiatrySimplified]

Thank you 🙏🏻

[@mikeythearchangel]

@@PsychiatrySimplified You are not only more than welcome sir - but I was further impressed by your video when you chose to begin your story using the analogy of Levomethamphetamine in OTC products… I think more people should be aware of these fascinating quirks of chemistry, don’t you? ;)

[@PsychiatrySimplified]

Good analogy with the train! Yes astounding when we think of the role of mETH in society

[@bharatmadho3742]

on 4:12 the subtitles say "biophilic" but i think that is supposed to be "lipophillic". Thank you very much for the subtites! English is not my first language and i appreciate it lots!

[@user-to2gh7sg3l]

This is good research and well explained. Thanks for breaking it down.

[@PsychiatrySimplified]

Thanks for the feedback 🙏🏼

[@dudeman8323]

I do remember people hooked on the vics inhaler thingys... makes sense now...😊

[@sykoteddy]

Thank you for an exellent video with facts nonstop! Recently a friend and I was discussing how weird it is that MDMA, that is made from Methamphetamine is so risky in Serotonin depleation. I didn't know Methamphetamine itself was like that. But what is it that makes it this way compared to Amphetamine? Is it that S-Amphetamine that is responsible for this too? How? I didn't know there were Isomers and different types of these Amphetamines earlier. I only knew that about Ketamin. Does most subtances have this? I just discovered your channel and will look through your videos. Looking forward to future videos!

[@Sniperboy5551]

Methamphetamine has weak effects on serotonin, at least compared to MDMA. MDMA has the meth chemical scaffold, but it’s much, much more focused on serotonin. Long-term meth use in high doses can deplete serotonin, but using MDMA once can leave you with barely any serotonin for days. It all comes down to frequency of use, really. Amphetamine itself has negligible effects on serotonin.

[@Trigex]

​@Sniperboy5551 Meth compared to amphetamine has pretty profound effects on serotonin, it contributes a bunch to the high. But yeah still not nearly as much as mdma

[@katherineleflufy7693]

Thank you so much that is the most - actually the only - usefully detailed information on adhd medication rather than just the same ol basic gumph. I have found anywhere, being both detailed and clearly explained.

[@PsychiatrySimplified]

Thank you 🙏🏻

[@fishingfan1500]

I have never thought about the differences between the two, but when I saw this video I'm now interested.

[@Mark-ex3fk]

Methamphetamine is almost like a crack cocaine high that lasts 16+ hours and also meth releases slightly more dopamine than crack cocaine but not by much depending on quality of each drug that is. The dopamine comparison is very close but meth would still be more dominant than the crack.

[@DoctorDriftTheWhip]

Crack tastes wayyy better than meth

[@leacipurr]

@@DoctorDriftTheWhip I'm going to agree with DoctorDrift here.

[@dreece2000]

Are you speaking from experience

[@creativeexperience6388]

I love meth way to much but I'm 2 years clean

[@dustinchapman5211]

which ever one is currently present is the better tasting i would argue

[@gorillaguerillaDK]

This was an awesome video! The first many times I snorted methamphetamine, it was in combination with drinking lot of alcohol, so it wasn’t really until I tried it without drinking alcohol that I fully experienced what it could do for me… Since then, I’ve taken A LOT of it! It made me calm, far less aggressive, and more capable of being "present", less clumsy, better at conversations, and also at studying. But it also often ended in taking far more I needed to achieve the benefit, so long periods without sleep, long periods where I made a living of selling it and similar substances, also meant I tended to end up at Monday night parties that had started on a Wednesday…. I also used it a lot while I was in the Army, and it’s freaking wild that I never got caught! The few times I’ve been tested, in sports and in the Army, was always when I hadn’t taken any for a while! Two of the tests in the Army I got told they wanted to test me because I seemed more aggressive, easily distracted, had problems staying on topic when talking, had failed some of my responsibilities, made mistakes I didn’t usually make, forgot things more often than usual, would interrupt/speak out of turn also when addressing people above my rank, I had gotten a couple of stupid traffic tickets by the Military Police (and they had noted my behavior was "suspicious"), and at times they felt I seemed almost erratic…. But both times, it was several weeks since I had taken anything. Long after I left the Army and around a year after I had left "the substance use environment" behind, I had an appointment with a Psychiatrist! I had already been diagnosed with PTSD when I left the Army, and Depression shortly after that! But after a few consultations, he picked a book on the shelf, told me to listen carefully and tell me if anything of what he read out loud sounded familiar - and apparently he had a book that was written about me with the title ADHD! This was in the 00's and I was in my 30's - and he started me up on Ritalin and later on he combined it with Strattera. What a difference that made - it made it much easier for me to study and get an education within the health and healthcare sector. But after years on medicine and psychoeducation, which helped a lot on some of my issues, it was like other symptoms got stronger and then I met this woman who knew a lot about ASD in adults and some of her friends had a lot of insight into this as well - and after having been asked a couple of times about how long ago I had been diagnosed with ASD and telling them that I didn’t have ASD, and on both occasions they had just looked confused at me, and one of them had asked me "are you absolutely sure?", and with the other she had just smiled and then said "you’re definitely autist"! So, I once again ended up at a Psychiatrist, for new evaluation! And it turned out that I have ASD as well - so with the BPH (I probably got from taking the Strattera), and various comorbidities, I got more than enough letters to sustain myself on Alphabet Soup in case SHTF! But my last Psychiatrist replaced my Ritalin and Strattera with Attentin, Aduvanz/Elvanse, and Intuniv! I get fairly high doses, but Blood Tests has shown that the biological half-life (or is it the plasma half-life they measure?), is pretty fast - the same goes for the Duloxetin I take as well, so I wonder if it’s due to the same mechanisms - anyone knows anything about that? I also got very high Dosis of Ritalin when I was on that - so maybe I just burn through it faster? Can this be due to the huge amount of methamphetamine I used to take when I was younger? I’m also a big bastard, Scandinavian, the Thor type you see in God of War Ragnarok, but just more blond, can any of these factors play a role in why I need higher doses for it to have the needed effect? Adderall isn’t approved in my country, but I can’t help wonder if the mix of amphetamine salts in Adderall works better than the combination I get from dexamphetamine and lisdexamphetamine - anyone know anything about that?

[@PsychiatrySimplified]

Thanks for sharing your interesting story. There is evidence that individuals with substance use especially Meth need higher doses of stimulants - this is mainly due to the changes in dopaminergic pathways with previous use. While IR and XR can be combined it’s important to recognise the targets being treated . Of cognition and activity are targets then before increasing doses it’s important to look at sleep and arousal - addressing this becomes important as it allows for the doses of others to remain lower and can be more effective . Something to look at.

[@FilosophicalPharmer]

Greatly enjoy learning things I did not expect to learn. I’m 54 and now understand why my grandfather always had a tube of Vick’s Inhaler with him.

[@sn1000k]

I don't think Vicks is psychoactive. Benzedrine inhalers were different.

[@FilosophicalPharmer]

@@sn1000k Whoa! Hold on a second! You’re saying the stories my grandfather told about him being so old, he had to ride a dragon to sorcerer’s school are untrue…?!?

[@paulstan2449]

Thanks for the concise overview doc. I’m an older guy and finding lectures that can update my knowledge without having to go back to school is really helpful!

[@PsychiatrySimplified]

Very welcome!

[@iancopestick6757]

I've always wanted to know. Thank you 😮

[@PsychiatrySimplified]

Glad you found it useful 🙏🏻

[@Wintermute909]

Very informative video! But doesn't comparing adderal xr (extended release with what is basically instant release meth give skewed results if your looking at the amount of the drug in ng/l?

[@PsychiatrySimplified]

Aim was mainly to compare the two substances. You are correct it’s very different as it’s the phasic DA release that is the issue. Also route of administration which was highlighted.

[@Wintermute909]

@@PsychiatrySimplified cheers! Also thank you so much for your video on the neurochemistry of dex & methylphenidate! It was invaluable, especially since most other KZbin vids I've found on that subject are much more simplified. It'd be super fascinating if you ever get the time to cover the rest of the neuron in the same manner! (even if it's not directly related to adhd)

[@PsychiatrySimplified]

@@Wintermute909 hopefully yes 👍. Thanks for the feedback

[@Redacted44]

I like that this guy looks like he hasn’t slept in 3 days, eyes wide as can be, and that haven’t shaved because of been binging on phetamines for the past 3 days… I like it because it means this guy does his homework, and you can trust he knows what he’s saying. 😹

[@PsychiatrySimplified]

😂

[@obinator9065]

@@PsychiatrySimplifiedVideo on Ritalin vs Cocaine next?

[@JAIMOUStheFAMOUS]

Came here to say this!

[@neffix6976]

Well, in term of recreational use, ive heard a lot of people say theres practically no difference if take orally (in term of feeling, duration is longer ofc). There also seems to be quite more interesting differences in stereo isomers than if methylated or not.....

[@theEVILone0130]

There is a difference Drinking it in a cup of coffee doesn't give you much of a rush. Snorting gives you a rush but not very intense. Smoking it instead gives you a really good intense rush. Running it gives you an extremely intense rush . The rush can vary in intensity and they last pretty much the same amount of time. And the overall high ends up about the same. And length of time. The only real difference is the intensity of the rush.

[@neffix7917]

@@theEVILone0130 ...which should be moduletable with the dosage taken

[@danielglenn8976]

Great info thank you

[@PsychiatrySimplified]

Glad it was helpful!

[@MrFunkinPure]

Used to love taking Ecstasy in the late 80s early 90s. We’d get into a club, neck a pill. Then snort half a pill. Then chase a quarter. By the time the chase was over, you’d have come up on the nose and same again for the drop. We were having it from the minute the club opened. Great times dancing all night. I miss Rage every Thursday to this day

[@Faffy58]

Would appreciate more information on the effects of amphetamines on the cardiovascular & pulmonary system. I mean, interesting to learn about the chemical differences between meth and say Adderall, but I think most YT viewers aren’t methamphetamine addicts. More like ADHD users of prescribed stimulants who have concerns & questions about their efficacy, safety, dosage, long-term use & use among different age groups.

[@PsychiatrySimplified]

I’ve done a video on dexamphetamine vs methylphenidate if that helps. Overall they are safe in the correct doses, and when appropriately prescribed. kzbin.info/www/bejne/rWWXc4uCdrmna9ksi=eiKCl_txxPWLj-Sq

[@PsychiatrySimplified]

And we’ve also done a clondine vs Guanfacine video - which provides an understanding of the key aims in ADHD management.

[@explorerryan]

Thanks thus is very insightful

[@Thanks-Again]

I had always wondered about this!

[@slmslmlol]

Hi Dr. Rege, can you also make a video explaining differents between adderall vs vyvanse and also can we combine adderall with vyvanse? Thank you

[@ChardeeMacdennis339]

Hi! I wouldn’t recommend combining the two. Adderall contains amphetamine salts directly while Vyvanse uses lisdexamfetamine as a “prodrug,” which gets converted into an active form in the body before it has any effects. Adderall will start taking effect faster because it gets metabolized in the stomach. Vyvanse starts taking effect in your intestines. They are both amphetamines. Just different formulations. Vyvanse is typically “smoother” and lasts longer than adderall. I have taken both for adhd. Anyway talk to your doctor. Don’t take both at the same time because are essentially two sides of the same coin. I can’t imagine any doctor advising you to take both at once. Good luck.

[@omega3fatass61]

Vyvanse is just dexamphetamine only in a pro drug release form. it's a better vehicle for an XR effect

[@gorillaguerillaDK]

@@ChardeeMacdennis339 I get both dexamphetamine and lisdexamphetamine, and I know others who get both as well - it works perfect together! The dexamphetamine acts faster, but also have a faster half-life, the lisdexamphetamine has a more prolonged effect, but it still burns out so to get the best coverage, I get booth in the early morning, around 0530, and at 1200 I get half the dose of Lisdexamphetamine I got in the morning, and around 1430-1500 I get dexamphetamine again, half the dose I got in the morning. I used to get something similar when I was on Ritalin/Ritalin Uno. And I get fairly high doses in the morning, but it helps me wake up and get the day started! If I only got the Lisdexamphetamine, I would have a very hard time getting up in the morning! I often joke about how my Monster Energy Drink and my Pills are my substitute Coffe! (I don’t like coffe, and as a kid I’ve always been told that when I grew up and became an adult I would learn to love it - so Im a "kid" in my mid fifties….)

[@imonymous]

​@@ChardeeMacdennis339It's been almost ten years since I was prescribed Vyvanse so there may have been new research since then, but when Vyvanse first came out, I was prescribed it. I had been taking only Adderall up to that point, but even with the Vyvanse, I still took Adderall to complement it if I felt the vyvanse was wearing off. I had three more doctors continuing the same prescription until 2013 and i never heard any mention of it being a harmful combination.

[@alzyn8661]

Thaks this is good choice since near in terms of letters make confusion

[@raddastronaut]

Excellent work.

[@PsychiatrySimplified]

Thank you! Cheers!

[@mattiemathis9549]

As an adult “recently” diagnosed with ADD, I really appreciate this video. Have you thought about a video on the effects and use of amphetamines for asthma? Creepy crawlies are not my thing, but my roommate has asthma and was prescribed some pretty sketchy stuff back in the day. He actually used “speed” to control his asthma when he didn’t have health insurance. I don’t know what the difference is between speed and meth, but I am curious if you could explain it.

[@jazeenharal6013]

Same stuff, far as I know. "Speed" is just street slang for any amphetamine, including meth.

[@rebecca_stone]

Thank you so much for covering this topic. As someone who was diagnosed only a few years ago with quite significantly severe ADHD, I'm so fed up with the public's comments such as "ADHD meds are basically meth", your factual explanation will help with this stigma and untruth. I can say first hand my ADHD meds DO NOT cause me any type of euphoria, and have solved my insomnia. I take dexamphetamine 3 x per day and am prone to forgetting to take it, so use a timer and pill counter. Name me an "addict" who forgets to take their drug of choice. I hope your video reaches a lot of people.

[@PsychiatrySimplified]

Thank you for your feedback and I am glad you found it useful

[@jacobmiller6189]

As a 25 yr heroin and meth addict all I got to say to u is try to go 3 days without it. That is the ultimate addiction test bro

[@kanedNunable]

depends on how much you ingest tho i would assume? the mg etc

[@maryu8328]

yet people in the comments spouting bs like they clearly didn't watch a second of it lol. "i snorted 3 adderals a day in high school and i can tell you that adhd drugs are totally meth" 🤦‍♀️🙄

[@courtneyfrewin6306]

If anything this video showed that the main differences are dose and routes of administration... If you compared an oral extended release formulation of methamphetamine at an equivalent dose to oral extended release amphetamine, they would likely be very similar. There are of course less studies on meth because it's illegal.

[@aethyrien]

Thumbs up'd and subscribed. Your delivery when explaining complex material is perfection. Thank you for this.

[@PsychiatrySimplified]

Thank you for your feedback 🙏🏼

[@echo1434]

The medicated version of Vicks Inhalers in the U.S. still contains 50 mg of levoamphetamine per inhaler. They use the obscure spelling "levmetamfetamine" to keep it on the down low. It's not a very desirable substance recreationally, otherwise they wouldn't still be selling it.

[@PsychiatrySimplified]

Yes it does

[@amyyoung2804]

Thank you Dr. for this information. 😊

[@PsychiatrySimplified]

Pleasure

[@lestvee2001]

Nicely done. Would enjoy one with their "trippy older brothers" 3-4, methylenedioxyamphetamine(MDA) & 3-4, methylenedioxymethamphetamine(MDMA). What a difference an indole ring makes. Clinically, their effects are just this side of miraculous. And here in Oakland, mushrooms🍄 are legal. (Hell, the speed might as well be, almost impossible to catch a drug felony in CA, illegal white powders)😎🤓 The numbers were fascinating.

[@dalethomasdewitt]

indole is the wrong nomenclature. The methylene dioxy functionality is chemically akin to an ether.

[@adrianteo2421]

F*** no wonder my friends in primary school always gets high and fail their exams. They kept snorting that damn Vicks Inhaller in the 90s.

[@PsychiatrySimplified]

Is that right? Wow I didn't know people used this for exams.

[@KlausSchwab-uq9sl]

they dont the levo part is not very psychoactive

[@isabellalive2.081]

THE only side effect known to check your theory would be higher test scores!!!! Not lower, Just remember they do not let you compete in sporting events while on these substances for a reason & we give them to airplane pilots befor letting a single one go into the air ( Military ) , everyone is dosed! It is a functioning performance enhancer reaction times , & ability to remain focused & remember to execute your training in every & all circumstances. Let RAM Function be. I am RAM. I have been on Amphetamines so long since I was a Small Child I feel a thousand years old if a Day & I Am beginning TO MATURE. People Are Too Dream & Live & Love . Children are to Have newness of Life , God is Good . I choose TO serve Becasue THE light inside us I serve is Christ Jesus THE Lord .

[@Sniperboy5551]

Stimulants can’t make idiots any smarter 😂

[@PeaceLoveUnity4Ever]

One last thing, there are plenty of people who do not become psychotic on crystal meth. Everyone I knew who did crystal meth, back when I did it, had zero psychosis using it. I did form psychosis while using crystal meth, at one point, as a result of staying up too late. Then, I stopped staying up too late and didn't experience any psychosis on the drug after getting proper sleep. Someone I used with who knew Chemistry and was a pharmacy technician, and used crystal meth for over a decade without experiencing any psychosis, told me I needed to get proper sleep if I was to use crystal meth with him. We took breaks, where we would not use for 3 days and then use again. People need to learn harm reduction when using any drug, including crystal meth. Crystal Meth, for most people, will not be a problem if people get proper sleep, eat well, take care of their hygiene, and don't use too much. All of that is possible to do while using crystal meth, and if people do that then they won't be discovered for their meth use. You can only tell if someone is using crystal meth if that person stays up too late, does way too much of it, and neglects to take care of their personal health. That is a small minority of crystal meth users. I only saw one person in my life, back when I used crystal meth, who fit the popular stereotype. You are not helping people by pushing misinformation. I have studied drugs, studied addiction, and I have also the experience of doing these drugs and being around people doing these drugs to know better. You are smart enough to know this, or you are not educated on this topic; which, either way, makes you part of the problem.

[@Brainbaskit]

You are completely talking out your ass and a text book case of someone in denial about addiction. "I have studied drugs..." Lol fuck outta here

[@sn1000k]

I agree.

[@haniespanieldollis]

Thanks Doc! 😊

[@PsychiatrySimplified]

My pleasure!

[@eirini98]

Great video, as always! I have a question: If someone chronically abuses methamphetamine or amphetamine, leading to issues such as cardiomyopathy or blood circulation problems, are these conditions reversible? Some doctors are afraid to prescribe amphetamines; maybe they are afraid of these conditions developing. I'd appreciate your input, Dr.

[@PsychiatrySimplified]

Abuse at high doses can result in longer term issues - but this depend on the severity. In terms of reversibility I wouldn't be able to give a definitive answer as such cases would be seen in greater portion by a cardiologist who may have a better idea. Amphetamines in therapeutic doses are safe

[@eirini98]

Thanks for the swift reply! @@PsychiatrySimplified

[@erock.steady]

typically you find dangerous propaganda and disinformation about this topic. instead you're serving the community with good information. thank you.

[@GALACTUS-WORLD-EATER]

a great in depth explanation.

[@PsychiatrySimplified]

Thanks 🙏🏻

[@heartsingssacredsongsuntol6782]

The vicks inhaler still does have the l-isomer ss the main ingredient to reduce a runy nose Levmetamfetamine i believe is listed on the side of each. Its a good and long acting decongestsnt, and reduces inflammation.

[@Tamilan903]

Super explained

[@PsychiatrySimplified]

Thank you 🙂

[@myristicinman4566]

So here we are largely comparing therapeutic doses of orally administered amphetamine sulphate to excessive, recreational, vaporized doses of n-methylamphetamine hcl (enantiomers aside). Is this a fair comparison?

[@PsychiatrySimplified]

It was a commonly asked question in comments in the other videos. Also- Desoxyn oral Methamphetamine is prescribed in ADHD in US. Note oral amphetamine when misused can also lead to a similar picture albeit the speed of action and levels are not as high.

[@myristicinman4566]

@@PsychiatrySimplified Apologies if this comment was interpreted as hostile, and props to you for even making mention of these distinctions. The overwhelming majority of available literature regarding (meth)amphetamine toxicity vs therapeutic efficacy is rife with biased narrative, as I'm sure you are aware. But while I understand it is a delicate matter addressing this information to a general audience, I have witnessed far more harm than good come of perpetuating the narrative that adderall=good, meth=bad

[@PsychiatrySimplified]

@@myristicinman4566 Agree - And no I didn't think of it as rude. It was a fair comment. Adderall misused o inappropriately prescribed can have detrimental consequences as well.

[@KlausSchwab-uq9sl]

this is an honest description ive abused both.....they really both screwed me up i want so bad to go back to my time and brain before amphetamine and sometimes meth(crystal)

[@JM-ep1wx]

I know one thing. Amphetamine makes me feel like I’m in a drug. But methamphetamine makes me feel normal, like this is how is should feel all the time. It’s also nearly impossible to get an alcohol hangover when using both versions.

[@BL2197]

I'm 47 amd have always suffered from hayfever. I remember telling the doctor as a teenager the Vicks inhalers worked really well, but were hard to give up/get off. To me they seemed addictive at the time.

[@PsychiatrySimplified]

Wow! Wonder if people actually misused it - I’m sure probably did

[@BL2197]

@PsychiatrySimplified I didnt get high off it, but I did only use it in the recommended quantities I.e. 1 or 2 puffs per nostril. I just remember my nasal passages just seemed to close up worse than before when I stopped using it and I felt like I needed to take more nasal spray more often, so I stopped using it.

[@strangeportents]

Pretty sure this guy tried them all for this video. Look at the man's eyes. Sleep my man

[@James-Johnson313]

I just found your channel, uou should have a million subscribers!!! I liked, subscribed and forwarded this video.

[@PsychiatrySimplified]

I appreciate your feedback 🙏🏼. Thank you for sharing

[@nonsuch]

Thanks for the comparison. I've been prescribed Amphetamines for over 30 years for a few different reasons. Although, It seems to work slightly different for me than the average person. While people claim to get "euphoria" even from Amphetamines, I do not. I only remember "feeling" anything the first few times long ago but, wouldn't call it euphoric. Being that I've only ever taken it orally might be the reason for that. At this point, the dosage I take daily is considered fairly high. I've never had Methamphetamine and never will so, I can't personally compare the two.

[@yinyang2385]

Could you make a video around harm reduction for methamphetamine. Because realistically speaking while these videos are concerning they don't help people like myself with quitting the drug because of the difficulty giving up the addiction. So approaching the point from a more realistic point of view it would help to know what someone using could do to counteract the oxiditive stress and harmful effects. For example taking a specific supplement or drug that may have neuroprotective effects against methamphetamine or suggesting something that could serve as an anti-oxident.

[@PsychiatrySimplified]

Yes I understand. Perhaps todays video release will help. Should be released in a few hours . I understand where you are coming from - the harm reduction aspects. Basic principles would include ensuring adequate sleep ( treating with meds if needed ) , diet and supplements such as NAC show benefit in reducing oxidative stress but don’t necessarily address the actual craving in mETH use. Ps not advice

[@yinyang2385]

@@PsychiatrySimplified Thank you. Personally I load up on anti oxidents and take propranalol which according to Pubmed states that " The β-adrenoceptor antagonist, propranolol, is one of the few that has been reported to prevent METH-induced hyperthermia in laboratory mice". There have been times when I've overdosed on meth and found that valium helps with mucle rigidity and reduce hyperthermia and weirdly enough vitamin c has also been reported to reverse the effects specifically to dexamphetamine

[@robertblackmore703]

Excellent presentation. Do you have one of these for MDMA?

[@PsychiatrySimplified]

Not yet. On the list

[@fredread9216]

Thanks for all of this valuable information. I am an addiction peer councilor. Will subscribe. The more knowledge, the better in dealing with addiction.

[@PsychiatrySimplified]

Thanks 🙏🏻

[@angusseletto1511]

Your title got me watching ❤ Awesome

[@PsychiatrySimplified]

Glad you liked it!!

[@pieternel101]

Very good. thank you.

[@PsychiatrySimplified]

🙏🏼

[@Dutchenter]

S and R is that the same compared to S/R ketamine? and another question: my adhd meds kind of stopped working over time. How i could get motivation back because im too tired to make some positive changes.... :) Hope you, or someone else with experience can help me with some advice! Greets

[@PsychiatrySimplified]

Yes isomers - R and S - left and right in Latin. With ADHD meds when this happens - 1. Identify specific symptoms 2. Sleep ? 3. Usually it’s due to stress increase , sleep worsening , anxiety 4. Rule out medical issues / contributors 5. Rule out presence of other psychiatric issues - depression etc 6. Dose adjustment or augmentation or switch etc are other steps

[@Dutchenter]

@@PsychiatrySimplified probably lack of sleep... But Thanks for the comments i made a screenshot ;) I think because my eating habits have gotten worse, no daily routine - because i! between jobs, sleeping at random moments just for 1-2 hours at a time. No rouiine, ... This all combined with mind

[@PsychiatrySimplified]

Sleep 1-2 hrs? It’s really important to address that.

[@Ryan-sl8mw]

I snorted methamphetamine thinking it was cocaine. I can understand why someone would destroy their life for it. It was intense !

[@markharder3676]

Orally administered free-base d-Amphetamine is absorbed in seconds. Probably because of the increased lipophilicity of the uncharged molecule. It is somewhat caustic for the same reason.

[@adamkahn8645]

i think you explained it really well

[@PsychiatrySimplified]

Thank you 🙏🏻

[@MontezumasViper]

There are a couple studies that show that clinical levels of Adderall use (20 to 30mg) lead to a loss of dopamine in the corpus striatum and perhaps elsewhere, as much as 50% after as short as 6 weeks of daily use. Is it possible that this level of Adderall causing lasting brain damage? I have actively avoided continuous use of any stimulant because of this kind of risk.

[@Sniperboy5551]

Was that study done on people who were diagnosed with ADHD or with non-ADHD controls?

[@lilbatty]

apparently amphetamines can be neurotoxic while methlyphenidate is not neurotoxic

[@MontezumasViper]

Worst that happens with Methylphenidate is an increase in reuptake transporters. That will probably reverse over time. It's pretty safe in comparison to Adderall I think. Oddly enough, I wonder if meth is safer because it's so much more powerful at low doses prescribed?

[@lilbatty]

@@MontezumasViper u mean amphetamines? Yea i dont know the newer doctors seem to prescribe adderall while the old ones do ritalin first

[@lilbatty]

@@MontezumasViper my doc put me on ritalin first because she said adderall is too strong

[@El-Toro.]

This is really very educational ❤❤

[@PsychiatrySimplified]

Thank you 🙏🏼

[@TheMrBennito]

I would be very interested in your take on mono- vs polypharmacy in general and specifically concerning antipsychotics prescribed for ASD patients. In Great Britain a workbook has been published(I think University of Bristol) on polypharmacy (antipychotics) for workers in psychiatry. It clearly promotes monotherapy and warns for multiple negative effects of specific forms of polypharmacy, the lat can be used/applied yet only in specific (and, in the workbook, specified) situations.

[@PsychiatrySimplified]

Synergy in the context of poly pharmacy is very efficacious when done well. This is also evidence based. Hormesis means that doses of medications follow a hormetic curve - too high a dose and there are negative effects or side effects . Like in diabetes , pain medicine - where 3 medications are better than one - the same principle applies.

[@TheMrBennito]

thank you. Concerning hormetic curve: too high a dose and it effects, in monotherapy that would be , say, almost common sense; do you mean that in polypharmacy a too high a dose on, say, only one out of 2 or 3, in general, could have a greater negative impact on the workings of the combi than raising the dose of that single medication to the same, too high dose in monotherapy would have?@@PsychiatrySimplified

[@PsychiatrySimplified]

Let’s say a patient has vivid dreams, nightmares leading to waking up in the middle of the night several times along with racing thoughts and emotional dysregulation. The diagnosis could be part of a bipolar illness or ptsd or both etc. here a clinician may decide on Lamotrigine as part of evidence based treatment. They optimise the dose at 100 mg and find that emotional regulation and racing though subside significantly but the sleep issue doesn’t ( different mechanism) . So they increase the dose - the dose goes up to 300 mg - here despite this increase the sleep doesn’t improve to the extent needed. But side effects do . Lamotrigine has passed the hormetic curve. The mechanism of the sleep dysfunction is hyperarousal ( NA ⬆️) , so adding clonidine 50-100 mcg will treat the hyperarousal. Similarly if the clinician decides on treating hyperarousal first and optimises clonidine at 100 mcg - the nightmares cease the patient is sleeping well but they find that racing thoughts and emotional dysregulation continue. Here increasing clonidine will increase SE but not treat the emotional dyareguatlion. In such a case Lamotrigine 75-100 mg plus clonidine 50-100 mcg will have a synergistic effect compared to any one. Analogy is diabetes medications - different mechanisms are applied to the issue. Triple therapy with statins etc

[@bicyclist2]

Im over 40 but never used any of the medicine mentioned here. This is very interesting. Thank you.

[@PsychiatrySimplified]

Glad it was helpful!

[@bpj1805]

The molecules shown at 1:49, labelled S-methamphetamine and R-methamphetamine are not mirror images of each other, let alone having any resemblance to actual methamphetamine.

[@DingDongDaddyFromDumas]

That’s the structure of blue meth

[@austincrittenden5363]

Yup, not the chili meth anymore

[@eucalyptux]

thoses illustrations are far from being accurate

[@JustinSmith-ie3vt]

Amphetamine (as a racemic mix of D and L stereoisomers) is a mainstay of therapy for ADHD, as described in this video and is also essential for treating those suffering from type 1 or type 2 narcolepsy.

[@PsychiatrySimplified]

Yes true. Methylphenidate can also be used

[@ShannonDove-sy7ye]

I thought most formulations was 75/25,...25% levo?

[@nievelsteinmusic612]

So the pharmaceutical Dex amphetamine also contains levo-amphetamine? I thought that this is the street amphetamine mixture. Speed. Which gives a stronger high than just Dextro amphetamine by itself.

[@ShannonDove-sy7ye]

@@nievelsteinmusic612 dextro is the only isomer that gives a good high, levo is basically cut, or equivalent to cut or filler material. So 100% dextro is the best, it's what a user would want

[@ShannonDove-sy7ye]

@@nievelsteinmusic612 of course some formulations have both, for example, Adderall has some levo in it, as others have stated

[@JustLivinMyBestLifeMfer]

Yeah, I’m just looking into what medication my wife is taking and maybe get some insight on the difference because she used to have a problem so I’m trying to get as much information as possible

[@ChardeeMacdennis339]

Out of curiosity what med is she using, is it prescribed for her? And what did she have a problem with previously?

[@Fishtory]

Thank you, great break down. I hope you can do this with opiods to compare bioavailability ROI/ROC . I Feel the elephant in the room about opiate abuse, is most users with an RX were abusing these factors long before turning to the street. But if taken as rx the results are very different.

[@PsychiatrySimplified]

Thanks. Yes will be doing a video on opioid use

[@ladyscarfaceangel4616]

Sharing my own personal experiences here. I do not have ADHD. I do have other mental disorders that were triggered by past drug usage & childhood trauma. My body does not respond well to heavy stimulants. I experienced psychosis with past meth abuse & I've also experienced psychosis & extreme anxiety from Adderall that was prescribed to me. I was misdiagnosed. My body just doesn't like what I would call extreme stimulants. I can handle a few cups of coffee. Beyond 2 cups I have issues.

[@Krisjoverovovejovovichtski]

Try GABA, its calming I don't recommend it but wouldn't valium be given to you just incase?

[@aidenfielding1348]

Weakling

[@Krisjoverovovejovovichtski]

@@aidenfielding1348 so funny

[@aidenfielding1348]

@@Krisjoverovovejovovichtski i wasnt talking to you

[@Krisjoverovovejovovichtski]

@@aidenfielding1348 ok well let's keep the name calling to people who say it to you not people with mental health issues

[@TLJH53]

Will you do this on long effects of Buprenorphine(Suboxone)?

[@PsychiatrySimplified]

Will come in due course

[@DonHitman-gt9cz]

I need that video. Only wanted a few months tops and 7 years later I'm slowly weening off myself and down to 4 MG a day since no clinic wants to lose customers

[@Day-ZDuke]

@@DonHitman-gt9cz....the problem is, none of the MAT drugs (methadone, suboxone, XR morphine) are designed to be used short term really. The ideal treatment course is a minimum of 1 year. Less than that, and like 90% of people end up relapsing Because ya okay you could ween the dope out of your system over a couple months...but the physical dependence is only part of the problem. It’s the mental part that is most difficult to overcome. That’s why the treatment is designed to be long term. Your brain has been wired to search for that fix, and often people abuse drugs for years before seeking treatment.....and you think that you can reverse years of addiction in a couple months? Almost never

[@sn1000k]

​@@DonHitman-gt9czwell done don keep it up. I got down to 1mg a day without any w/d. The rest of the way was a little rocky but I'm sub free now.

[@mattdeinken6580]

I'd love to hear about Nootropic stimulants

[@mattdeinken6580]

Like modafinil and modafinil analogues and derivatives

[@alanhamilton3789]

I have ADHD and they gave me amphetamines. I didn’t realize what it was, they just called it Adderall. So naive as I was, I was shocked when I tested positive on a drug test. As soon as I realized what it was I stopped taking it and have been scared to treat it with Amphetamines. I’m terrified of addiction. I especially saw a quick resistance to Vyvanse which actually worked really well for me at first. I also tried Strattera but had very odd side effects and bupropion I used for a bit but hated the shakiness. Finally decided to live with the ADHD.

[@lachousalle31]

I've tried amphetamine(adderall) and i ultimately switched back to methylphenidate(Ritalin) because I found that adderall had too much of a synthetic feeling and it was uncomfortable. Ritalin feels more like boost simular to caffeine but with more euphoria. I've read rhat methylphenidate is actually similar to how cocaine acts in the brain. Now I take the long acting version(Concerta) and it actually helps a lot with feelings of boredom and depression. It seems to be more effective for depression than antidepressants, which have never really done much besides blunt my emotions.

[@PsychiatrySimplified]

Amphetamines have a greater dopamine release than methylphenidate. They also release serotonin which MPH doesn’t . Overall amphetamine can be more activating than MPH for many individuals. Considering LA agents is beneficial as it mimics the tonic release of Dopamine rather than the phasic bursts which is not adaptive .

[@m00seknucklejohnson45]

Look into Focalin. Also known as dex-methylphenidate it also is somewhat “smoother” than the jittery adderall and better appetite than on adderall and very similar to Ritalin

[@ryancafferty4973]

it is. ritalin and cocaine are effect cousins. not chemically, but in terms of neurotransmitter modulation

[@EthanAndrews-dk6ff]

Meth feels smoother than Adderall at least for me but many seem to agree, less rigidness it's generally more of an euphoric feeling. Ritalin has an amazing rush and high but the most disgusting comedown I've experienced from any other stim, I'd pick a meth or even mdma comedown over a strong Ritalin crash anyday, everyone's different though

[@BS20-35]

Have there been any studies that look at the long term effects from stimulant medications on the cardiac system? Would love to hear your thoughts on if medications like Adderal and Ritalin are harmful from a cardiac perspective when they are taken as prescribed for conditions such as ADHD. As always love the videos.

[@PsychiatrySimplified]

“Although stimulants can increase systemic blood pressure and heart rate, no significant associations were found between their use and serious cardiovascular events. Concerns regarding QT effects and attendant sudden cardiac death risks deter clinicians from initiating much-needed ADHD medications in patients with heart disease. This overly cautious approach is potentially depriving low-risk individuals from significant benefits associated with timely ADHD drug treatment” - www.frontiersin.org/articles/10.3389/fnins.2022.1020961/full

[@JT0007]

There’s no way it doesn’t affect your heart. It puts your heart in overdrive. 🫡🇺🇸🏴󠁧󠁢󠁥󠁮󠁧󠁿

[@doaimanariroll5121]

Yes, modern stimulant medication is nearly a century old.

[@moustachio334]

Caffeine is worse

[@michelesperrow-chenie2445]

Really enjoyed the way you explain this!!! Especially effects of too much! Good to know!!! Are you a doctor? Can you recommend one like you? Thank you for the video! Can one safely take stimulant and non stimulant by prescription of course?

[@PsychiatrySimplified]

Thanks for the feedback. Yes a medical doctor specialising in psychiatry. Under supervision and if indicated stimulant plus a non stimulant medication can be prescribed and is commonly done

[@justinhawk6650]

In the USA, in 2014 (with my eyes) it was still available in the Vick's Vapor Inhaler. Just letting you know.

[@PsychiatrySimplified]

Probably was . Levometh still is

[@alt3rnatywa]

This is my personal extension. Let's be a recreational shooter. When I use amphetamines, the party ends and I go home. I used methamphetamine powder once and that was the first and last time. Too stimulating is a warning sign. As it does not penetrate alcohol, but stimulants such as XTC, mda/mdma or ampheramines. Let's use it as a means of recreation. If something has too much kick, don't use it again. Today I am almost 40 years old and I have no problem with using it. But definitely don't touch any crystals!

[@leslielearnorth]

The first time is amazing that’s why it’s so popular meth heads aren’t all bad people it’s really hard tu qut the come down is unbeatable when the cure is more meth you feel 1000x better it’s sad 11:45

[@alt3rnatywa]

@@leslielearnorth Yes, I'm not criticizing it. It was my personal opinion. And we need to make younger generations aware of this.

[@nandrolone.is.underated]

@@leslielearnorth i realy cant understand that at all it's probably due to some other drug/drugs they're taking or that they dont drink at all and become severely dehydrated and that's why they are feeling so bad on the comedown being dehydrated probably feels pretty shitty if you let it go to far. I use meth almost evryday but that is the only drug i use exept for steroids if you can call that a drug but that's all i dont ever take anything to sleep or smoke weed even alcohol is over 5 years since i last drank alcohol and i never ever get this bad comedowns on meth like i always enjoy the whole ride hell i would even take meth still if i was only gonna get the comedown part of the high like when im on my comedowns im always just playing some game having fun then when i get to the point where now i can go to sleep if i want to i usually force my self to stay awake for a few more houers couse im having so much fun playing games before i just eventually just fall asleep while still playing that's pretty much how 99% of my comedowns from meth ends up playìng out like how is that something to complain about. Meth comedowns is still a better high/state to be in than being sober drunk or on cocaine

[@sussekind9717]

The over the counter inhaler Benedrex is still sold OTC and it contains amphetamines. It is sold at drug stores and supermarkets. They add Menthol to it, so it is disgusting, if not impossible, to try and consume.

[@PsychiatrySimplified]

Bexedrex - containing propylhexedrine not available in Australia and many other countries - but available in US. You are correct there is significant misuse

[@AmazonianShamanGirl]

Very interesting❤

[@PsychiatrySimplified]

🙏🏻

[@TheMrBennito]

interesting that the 70s evoke mentioning of Vicks inhalers. I dont know about that, yet what I do know i that in the early 70s, I am dutch and went to highschool in Rotterdam, friends of mine used speed. Pills. It wasn't a secret in our group of friends. Actually there was a division in the group, sort of a cultural or class thing: working class kids tended toward speed, middle class kids (like me) to hashish='stuff'. It was either speed or stuff.I can clearly recall the effects on my friend Rene. He would be euphoric, talking a lot, infinite energy and it stimulated his creativity. In retrospect, I think it served as selfmedication for his ADHD. He had all the traits, yet there was nothing like an ADHD diagnosis at the time. That behavior wasnt recognized as such.

[@PsychiatrySimplified]

Thanks for sharing ! How did your friend do after school? Just curious?

[@TheMrBennito]

I lost sight of him... yet I have seen a destructive effect on others in my environment. They lost weight, showed erratic behavior after prolonged use and I think one of them developed psychosis, yet not sure if it was because the use of speed only. I think there was something like speedballs. Sort of a cocktail thing, coke & horse. Another friend, only 16 or 17 years old at the time, used this, very destructive. He ended up in what in Holland is called an "afkickboerderij", a farm to kick the habit. That place did wonders for him. He worked on the land, gained weight, no acne anymore and a suntan! Those 'farms', therapeutic communities, had a very strict regime, good food, therapy group etc It was revolutionary, at the time@@PsychiatrySimplified

[@PsychiatrySimplified]

Thank you for sharing. Really interesting

[@rayeannebrewer1458]

Another use for amphetamines is DEPRESSION. If used properly under clinical supervision to treat unipolar depression it can be very effective. They used to use amphetamines to treat depression before the advent of antidepressants as we know them today

[@PsychiatrySimplified]

That's correct. Dopaminergic agents are very effective in the treatment of depresssion

[@Inertia888]

From what I have gathered, they can be especially useful with seasonal affective disorder. Or 'the winter blues'.

[@NealBurkard-ut1oo]

Yeah. I was prescribed it for short term depression. Until I had access to better methods

[@Burningwitch616]

Lol drugs cause depression

[@sn1000k]

Heck yeah

[@alvinprettyman1802]

I knew people who ate the cotton out of Vick's inhales I used to buy bootleg black beauties a 100 at a time only did Methamphetamine once it was a horrible experience haven't done any booze or dope since Aug. 4 1985.

[@syzygy4365]

I've been on adderall since I was 11, this medication helps me so much in my everyday life. I got with someone who liked to abuse it then I made the bad choice if abusing it too. Long story short I've healed and I'm no longer taking them the wrong way anymore. One thing that helped me heal was getting put on presidone. When I was on it for 2 weeks I didn't feel the need to take my adhd medicine like that. It was the reset my body needed. Sharing this info to hopefully help someone else who's struggling to fix their nasal route problem. Also I'm sure there's some some doctors and psychologist on here that read this feed. Please look into this. Maybe it could help others scared to speak up, but want to make the change. ❤

[@PsychiatrySimplified]

Which medication were you put on? Thanks for sharing

[@syzygy4365]

@@PsychiatrySimplified Sorry, I misspelled Prednisone.

[@syzygy4365]

@@PsychiatrySimplified Prednisone orally Q.D. for 2 weeks.

[@bobann3566]

@@syzygy4365 Prednisone will make you fat, really fat.

[@ganglestank]

Would you be able to do a video on something like 2-fluoroamphetamine’s differences with these two?