SSRIs in the Brain: Understand Anti-Depressants and Why Anti-Depressants Take So Long to Work

Understand anti-depressants and the workings of SSRIs in the brain and why anti-depressants take so long to work
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The video helps you to under anti-depressants and explains the mechanism of action of SSRIs (Selective Serotonin Reuptake Inhibitors) and why they take time to show therapeutic effects by reviewing how SSRIs in the brain work. SSRIs block the serotonin transporter protein (SERT) in neurons, allowing serotonin to remain in the synapse longer, but this doesn't expalin Why Anti-depressants take so long to work. Initially, there's an increase in serotonin in the somatodendritic region, causing immediate side effects. This increase stimulates pre-synaptic 5-HT1A autoreceptors, triggering a negative feedback loop that downregulates these receptors over time. With decreased autoreceptor activity, serotonin release from axon terminals increases, leading to therapeutic effects in depression. The delayed onset of these effects is due to the time needed for downregulation and subsequent disinhibition of serotonin release. The video stresses that while the neurochemical model helps understand SSRIs' action, it's simplistic and not fully explanatory. It challenges the notion that SSRIs directly correct serotonin deficits, suggesting instead that they induce changes in the brain that eventually alleviate depression symptoms. These changes likely involve alterations in gene expression and protein synthesis. The video encourages humility in interpreting these models and acknowledges the complex interplay of neurochemistry, cognition, and psychology in understanding depression and its treatment.
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#depression #antidepressants #psychopharmacology
0:00 Intro, And it keeps coming
0:10 SSRI Intro
0:18 What Happens At the Neuron Level With SSRIs
0:36 SERT sucks (like a vacuum)
0:51 SSRIs block SERT
2:23 A Few Moments Later.....
2:42 5HT1A Receptors Down-Regulate
3:13 4-6 Weeks Later.....
3:23 Serotonin Releases!
4:13 Humble Closing Remarks
5:50 Outro

[@Wintermute909]

Fantastic video! It's great you went a bit beyond the basics like most YT vids, but it was still very easy to understand!

[@Robert_Presto]

This is a great video ! This is the best explanation on KZbin. !!! God Bless you !

[@ashleyzeleznik5388]

Just what I was looking for thanks

[@chinamn]

Thank you so much for making these! Currently an MS4 trying to match into psychiatry and these are helping a lot! You are a natural talent at teaching.

[@PsychoFarm]

Appreciate it Lawrence. Best of luck with the match!

[@MultiSciGeek]

But excellent videos man! If my psychiatrist explained it this clearly, and asked me relevant question - I would gave zero problem taking. But even without asking "are you on any other meds" in case of interaction, he just decided on the spot I need Paxil. Like literally in 30 seconds - take Paxil, bye. Now I'm slowly learning that might have been a mistake. But education is key! So much stigma and for people with anxiety, taking any drugs can be worse if they don't know what tf is going on.

[@angelamartin4329]

OMG. You changed my life. I love the design in your videos and the humor. The way you bring it all together. I am finally engaged in learning pharmacology.

[@amalmoallin]

Great work !

[@xXxC0nSUm3rXxX1337]

Glad you mentioned it's theoretical models at the end. Great video

[@PsychoFarm]

Thanks!

[@nptchang121]

Love the little Kendrick Lamar - HUMBLE reference. Fantastic work, thank you!

[@vijaybabu7857]

GREAT VIDEO MATE !! YOUR POV AT THE END OF THE VIDEO GAVE A SMILE ON MY FACE THINKING HOW COMPLEX OF A STRUCTURE IS OUR BRAIN. CHEERS B-)

[@PsychoFarm]

You're welcome! B-)

[@taaayll]

Your videos are gold. I’m shocked that they don’t have one million views.

[@PsychoFarm]

I agree

[@Tesseract9630]

this channel is gold.

[@kaoutarhabibi6284]

this was a very very easy video to understand than you so much .

[@polarbear1954]

Hahaha I love the Spongebob parts. You always come up with such creative and fun ways to explain your topics! :)

[@PsychoFarm]

Thanks!

[@polarbear1954]

@@PsychoFarm you are welcome!

[@TheRealFallingFist]

Fantastic video, we're doing neuropharmacology in my Pharm course right now, so this is highly relevant for me. You're quickly improving in your content-making. Looking forward to more videos :)

[@PsychoFarm]

Appreciate you noticing!

[@livea3596]

2:21 Are you saying the somatodendric region releases serotonin? I though serotonin was only released at the axon terminals. Could you clarify?

[@plockacherrys5765]

Do u have a video of the side effects?

[@emsdiy6857]

Wow thank you

[@PsychoFarm]

You’re welcome 😊

[@rufuzzbum2582]

I finish 4 week now for anxiety and i its getting better. But last 2 weeks...it was hell

[@ozzyhouston2535]

I just took some HMG, a supplement. I've read it has an effect on neurons. Hope I did the right thing.

[@RoSa-kr8hy]

Can you do a video on bupropion? I am especially interested in how it might benefit a person with depression and ADHD. Would also like to see something about atomoxetine.

[@PsychoFarm]

Done!

[@thomaslau9631]

How about Deanxit? How many weeks needed to work?

[@MultiSciGeek]

I was surprised, because I was told it would take 4 weeks, but I feel ringing in my ears within 30 minutes, weird muscle feelings 4 hours, massive diarrhea 6 hours later. Headache since two weeks now. It's kinda unbearable. And really scared of discontinuation syndrome and possible dependence... meaning if I stop, will my serotonin levels drop below the level at starting?

[@dimos3008]

how could possibly SSRI affect only in specific places if they target CERT which is the same protein in every part of a brain and tge drugs freely permit into brain?

[@CodyFIHS]

Works really enjoy an analysis of the NDRI bupropion and in depth info on norepinephrine and dopamine like you did here with serotonin. I take Sertraline 100mg and starting bupropion 150 xl. Your overview on SSRI video really helped understanding Sertraline. I take it for atypical depression, ptsd, ocd, gad.

[@jjsalas]

Does burpopion has this delated effect?

[@mohamedmashkor3378]

If a person is taking fluoxetene for a period of time, then he notices that it is not effective to alleviate his clinical condition can he switch to another type of SSRI drugs such as Sertraline safely ¿ Regards.

[@vrglcom]

Is Zoloft/sertraline supposed to completely eradicate anxiety/social phobia or just take the edge off?

[@JimmyStruthers1000]

I would say celexa (citalopram) is the best ssri for social anxiety/phobia. 20mg after about 6-8 weeks social anxiety disappears, doesnt even exist

[@XenoTravis]

I heard the drug can get stuck in the lipid rafts as well. Do you know if that is still a theory?

[@pr3287]

No

[@emsdiy6857]

I felt a total difference with in 1 hour

[@brad3097]

Intuitively wouldn't it make more sense that more 5HT1A terminals are created to handle the increased ssri load?

[@pennwoman]

Brain is always trying to achieve homeostasis.

[@RedMartyr]

If i ever obtain superpowers i will become a supervillain named Axon Terminal !!!

[@quantumpower]

1:56

[@mikestillshreddin7636]

Explained quite well.. just one small question i'm stuck on..., "huh?"

[@susanayala]

you rule!

[@PsychoFarm]

Thank you!

[@212productions6]

Pierre or Andrei?

[@dobie6929]

how bad is it to start a low dose prozac while having been , being and always will be using PED"s ?

[@PsychoFarm]

As a rule I don’t offer advice online. Would talk with your doc about it. Would prioritize finding a doc that you feel comfortable sharing these things and takes your values into account for making decisions.

[@dobie6929]

@@PsychoFarm alright, thank you do you have an email Id like to speak to you please

[@matthewgateoperators2406]

Actually I think it's a good idea. High doses of Androgens are neurotoxic. By supplementing something like Prozac you would be increasing bdnf thus protecting your brain, also serotonin is neuroprotective.

[@AlexandraStrauss-lt7gg]

citations?

[@dannyf5595]

Hey I want to take an SSRI for my health anxiety the problem is the one I thought was the safest for my heart Zoloft didn’t work for me =( any suggestions?

[@laobejanegra266]

Talk to your psychiatrist of a dose increase or try another ssri like paxil or lexapro

[@vincentvega3747]

Citalopram. Works great and its one of the ones which has the least side effects.

[@pr3287]

All of them are safe for your heart - that’s first. Second - you have heart illness or you are just anxious about your heart ?

[@pennwoman]

Depends which anxiety disorder you have. Avoid citalopram & escitalopram.

[@borayildirim4817]

???

[@phonixMAM]

skip the voice changer bit or make it less annoying next time