SSRIs in the Brain: Understand Anti-Depressants and Why Anti-Depressants Take So Long to Work

[@chinamn]

Thank you so much for making these! Currently an MS4 trying to match into psychiatry and these are helping a lot! You are a natural talent at teaching.

[@PsychoFarm]

Appreciate it Lawrence. Best of luck with the match!

[@MultiSciGeek]

But excellent videos man! If my psychiatrist explained it this clearly, and asked me relevant question - I would gave zero problem taking. But even without asking "are you on any other meds" in case of interaction, he just decided on the spot I need Paxil. Like literally in 30 seconds - take Paxil, bye. Now I'm slowly learning that might have been a mistake. But education is key! So much stigma and for people with anxiety, taking any drugs can be worse if they don't know what tf is going on.

[@taaayll]

Your videos are gold. I’m shocked that they don’t have one million views.

[@PsychoFarm]

I agree

[@Robert_Presto]

This is a great video ! This is the best explanation on KZbin. !!! God Bless you !

[@Tesseract9630]

this channel is gold.

[@ozzyhouston2535]

I just took some HMG, a supplement. I've read it has an effect on neurons. Hope I did the right thing.

[@vijaybabu7857]

GREAT VIDEO MATE !! YOUR POV AT THE END OF THE VIDEO GAVE A SMILE ON MY FACE THINKING HOW COMPLEX OF A STRUCTURE IS OUR BRAIN. CHEERS B-)

[@PsychoFarm]

You're welcome! B-)

[@xXxC0nSUm3rXxX1337]

Glad you mentioned it's theoretical models at the end. Great video

[@PsychoFarm]

Thanks!

[@dimos3008]

how could possibly SSRI affect only in specific places if they target CERT which is the same protein in every part of a brain and tge drugs freely permit into brain?

[@ashleyzeleznik5388]

Just what I was looking for thanks

[@mohamedmashkor3378]

If a person is taking fluoxetene for a period of time, then he notices that it is not effective to alleviate his clinical condition can he switch to another type of SSRI drugs such as Sertraline safely ¿ Regards.

[@vrglcom]

Is Zoloft/sertraline supposed to completely eradicate anxiety/social phobia or just take the edge off?

[@JimmyStruthers1000]

I would say celexa (citalopram) is the best ssri for social anxiety/phobia. 20mg after about 6-8 weeks social anxiety disappears, doesnt even exist

[@CodyFIHS]

Works really enjoy an analysis of the NDRI bupropion and in depth info on norepinephrine and dopamine like you did here with serotonin. I take Sertraline 100mg and starting bupropion 150 xl. Your overview on SSRI video really helped understanding Sertraline. I take it for atypical depression, ptsd, ocd, gad.

[@TheRealFallingFist]

Fantastic video, we're doing neuropharmacology in my Pharm course right now, so this is highly relevant for me. You're quickly improving in your content-making. Looking forward to more videos :)

[@PsychoFarm]

Appreciate you noticing!

[@amalmoallin]

Great work !

[@XenoTravis]

I heard the drug can get stuck in the lipid rafts as well. Do you know if that is still a theory?

[@pr3287]

No

[@livea3596]

2:21 Are you saying the somatodendric region releases serotonin? I though serotonin was only released at the axon terminals. Could you clarify?

[@plockacherrys5765]

Do u have a video of the side effects?

[@mikestillshreddin7636]

Explained quite well.. just one small question i'm stuck on..., "huh?"

[@quantumpower]

1:56

[@emsdiy6857]

I felt a total difference with in 1 hour

[@emsdiy6857]

Wow thank you

[@PsychoFarm]

You’re welcome 😊

[@thomaslau9631]

How about Deanxit? How many weeks needed to work?

[@jjsalas]

Does burpopion has this delated effect?

[@susanayala]

you rule!

[@PsychoFarm]

Thank you!

[@AlexandraStrauss-lt7gg]

citations?

[@dannyf5595]

Hey I want to take an SSRI for my health anxiety the problem is the one I thought was the safest for my heart Zoloft didn’t work for me =( any suggestions?

[@laobejanegra266]

Talk to your psychiatrist of a dose increase or try another ssri like paxil or lexapro

[@vincentvega3747]

Citalopram. Works great and its one of the ones which has the least side effects.

[@pr3287]

All of them are safe for your heart - that’s first. Second - you have heart illness or you are just anxious about your heart ?

[@pennwoman]

Depends which anxiety disorder you have. Avoid citalopram & escitalopram.

[@borayildirim4817]

???

[@phonixMAM]

skip the voice changer bit or make it less annoying next time

[@nptchang121]

Love the little Kendrick Lamar - HUMBLE reference. Fantastic work, thank you!

[@polarbear1954]

Hahaha I love the Spongebob parts. You always come up with such creative and fun ways to explain your topics! :)

[@PsychoFarm]

Thanks!

[@polarbear1954]

@@PsychoFarm you are welcome!

[@MultiSciGeek]

I was surprised, because I was told it would take 4 weeks, but I feel ringing in my ears within 30 minutes, weird muscle feelings 4 hours, massive diarrhea 6 hours later. Headache since two weeks now. It's kinda unbearable. And really scared of discontinuation syndrome and possible dependence... meaning if I stop, will my serotonin levels drop below the level at starting?

[@brad3097]

Intuitively wouldn't it make more sense that more 5HT1A terminals are created to handle the increased ssri load?

[@pennwoman]

Brain is always trying to achieve homeostasis.

[@rufuzzbum2582]

I finish 4 week now for anxiety and i its getting better. But last 2 weeks...it was hell

[@RedMartyr]

If i ever obtain superpowers i will become a supervillain named Axon Terminal !!!

[@RoSa-kr8hy]

Can you do a video on bupropion? I am especially interested in how it might benefit a person with depression and ADHD. Would also like to see something about atomoxetine.

[@PsychoFarm]

Done!

[@Wintermute909]

Fantastic video! It's great you went a bit beyond the basics like most YT vids, but it was still very easy to understand!

[@angelamartin4329]

OMG. You changed my life. I love the design in your videos and the humor. The way you bring it all together. I am finally engaged in learning pharmacology.

[@kaoutarhabibi6284]

this was a very very easy video to understand than you so much .

[@212productions6]

Pierre or Andrei?

[@dobie6929]

how bad is it to start a low dose prozac while having been , being and always will be using PED"s ?

[@PsychoFarm]

As a rule I don’t offer advice online. Would talk with your doc about it. Would prioritize finding a doc that you feel comfortable sharing these things and takes your values into account for making decisions.

[@dobie6929]

@@PsychoFarm alright, thank you do you have an email Id like to speak to you please

[@matthewgateoperators2406]

Actually I think it's a good idea. High doses of Androgens are neurotoxic. By supplementing something like Prozac you would be increasing bdnf thus protecting your brain, also serotonin is neuroprotective.