Radical Health Benefits of Autophagy

How to activate autophagy now for better health?
This question is most asked, and this topic is very researched. Let's review what we know so far.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Dr. Ana Maria Cuervo, MD, Ph.D
Macroautophagy starts within 30 minutes to an hour of starvation.
When do we starve?
In the intermittent fasting of 8-16. The macroautophagy starts within 8 hours if there are no snacks.
The chaperon mediated autophagy occurs during the 16 hours.
If you keep the 16 hours window including the sleep then the neurons are able to perform autophagy as well.
URL list from Thursday, Sep. 1 2022
Yoshinori Ohsumi - Wikipedia
en.wikipedia.org/wiki/Yoshino...
HOW LONG Does It Takes To Activate AUTOPHAGY? | Dr Ana Maria Cuervo Interview Clips - KZbin
• HOW LONG Does It Takes...
Short-term fasting induces profound neuronal autophagy - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
Autophagy: Definition, Process, Fasting & Signs
my.clevelandclinic.org/health...
6 Signs And Symptoms of Autophagy
www.healthline.com/nutrition/...
How Long do You Have to Fast for Autophagy? - spermidineLIFE® US
spermidinelife.us/blogs/news/....
How Long Do You Need to Fast for Autophagy?
www.medicinenet.com/how_long_...
Ana Maria Cuervo, M.D., Ph.D. | Faculty Directory | Albert Einstein College of Medicine
www.einsteinmed.edu/faculty/8...
Cuervo AM - Search Results - PubMed
pubmed.ncbi.nlm.nih.gov/?term...
The coming of age of chaperone-mediated autophagy - PubMed
pubmed.ncbi.nlm.nih.gov/29626...
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
Chaperone-mediated autophagy sustains haematopoietic stem-cell function - PubMed
pubmed.ncbi.nlm.nih.gov/33442...
Molecular definitions of autophagy and related processes - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
The different autophagy degradation pathways and neurodegeneration - PubMed
pubmed.ncbi.nlm.nih.gov/35134...
How Long Do You Need to Fast for Autophagy?
www.medicinenet.com/how_long_....
Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials | Cardiology | JAMA Network Open | JAMA Network
jamanetwork.com/journals/jama...
ADULT NEUROGENESIS IN HUMANS: A Review of Basic Concepts, History, Current Research, and Clinical Implications - PMC
www.ncbi.nlm.nih.gov/pmc/arti....
The 2016 Nobel Prize in Physiology or Medicine - Press release
www.nobelprize.org/prizes/med...

[@davidcoalkey6074]

I was experiencing brain fog after COVID. I started a keto diet and intermittent fasting and it fixed the brain fog. If I eat carbs again the brain fog comes back.

[@dede4004]

It's quite possible that the brain fog might not be coming from the covid. (Completely) The globalists have announced that they have been taking the nutrition OUT of our foods for several years now. They've engineered the crops in certain ways, changed the ingredients in ALL our foods, and taken out all necessary vitamins and minerals needed for our nutritional health. (And they're PROUD of this ) This got worse just the past couple years, in the foods with glucose, starches and sugars. Brain fog is the number one symptom of reacting to it, amongst many others. They have devised many different ways, all combined to kill us off in numerous ways, but not to raise "suspicions" of the people. It's really nefarious. THIS is what the mega rich come up with in the meetings in Davos, Bohemian Grove and Tavistock. (OUR demise, and their "take over" of the world". It sounds like a bad cartoon or comic villain, but it's genuine, believe it or not. Start searching into the "nutrition being removed from foods". Gates, the World Economic Forum with Klaus Schwab are the ones in charge of this. They have several videos on YT talking about this. And, their main goal is YES, to get rid of people. The vax, viruses, foods, water, medical over treatment, or under treatment, are some of the ways. But, it's all happening at once. Check it out, I think you'll find it enlightening.

[@ParallaxView111]

Good for you for making the change. I'm worried Bill Gates will cut the meat supply.

[@tommyortiz6623]

We’ll be careful your body will convert to what you feed it, so cut carbs is long term bad for health since you will not have microbs to break it down. I’m a nutritionist/dietician and I can tell you 65% carbs is the most effective/efficient for the mitochondria of our cells. The fix is resistance training so your body uses the carbs properly and converts it to muscle. Every decade= 6% body fat gain from lean muscle so you can see where I’m going with this. You get your carbs from veggies one fruit a day and whole grains such as sprouted oats.

[@davidcoalkey6074]

@@tommyortiz6623 I don't do the strict keto diet that's nothing but fats and protein. I consume a wide range of vegetables with emphasis on cruciferous vegetables. My primary source of protein comes from grass fed finished beef, wild game and eggs. I take my microbiome very seriously and make my own home made sauerkraut from red cabbage. I'm 43 years old and in excellent shape. I bench press well over my body weight, squat 1.5 times my body weight and dead lift double my body weight. I can also run a sub 7 minute mile.

[@LisaLightning]

A keto diet will kill you in the long run. It is not your friend. Maybe you don’t like carbs but meat is what causes most if not all chronic illnesses in this country.

[@db6331]

As an R.N. I found this discussion to be a great review but also offer new information I hadn’t heard 20 years ago in school. Listening to you keeps me updated and informed. I appreciate your teaching style and your drawings!

[@llkoolbean4935]

Excellent discussion Dr. Been. I do IF almost every day.and I gotta say, when my husband got COVID, I never tested positive for it. Never had any symptoms, etc... I really think it has contributed in strengthening my immune system.

[@tamaraspillis612]

Likewise IF. Doing well. People we are around socially and work had covid twice and more, vax and unvaxx. Some how we are ok.🙏😊

[@tamaraspillis612]

.

[@llkoolbean4935]

@@tamaraspillis612 👊👍❤️

[@deezeed2817]

I never feared covid myself because i've always known about the power of Autophagy and its ability to heal the body in amazing ways. I did if for weight loss but i tried doing 48 and 72 hours fasting. There's a guy on KZbin called Snake Diet who promotes this. I'm going to start doing it again.

[@bobhenderson7961]

Dr B we need more info on how to eliminate the spike protein from our bodies and what can we do to break it down - thanks

[@ladybug5859]

YES YES YES

[@lammilee1]

YES YES YES!!!

[@auggie1790]

That is what this lecture is about.

[@deezeed2817]

Fast for 48-72 hours, Drink water mixed with a bit of Himalayan salt and apple cider vinegar. I used to do this to lose weight but it actually helps with all sorts of diseases. Covid leaves alot of crap in your body and basically autophagy will get rid of all the crap in your body.

[@lammilee1]

@@deezeed2817 Thank you!

[@ernestinejohnson9022]

I used to only eat once daily, yet feels energized. Slim and strong. People would said to me that I was too slim, I finally started eating 2/3 times a day, gained weight but feels more tired. I wish I've stuck to my original way of eating. Thanks for all information you gives.

[@janetpelletier1238]

You probably hear "Well, just doing it again." LOL, not so easy. It's a matter of getting your mindset back, the moon cycle (haha), yeah, I find it difficult too to bring me back to my optimal place. I keep at it and know I'll get there again. I started snacking in the evening and can't break that stupid habit. I'm not hungry but created a habit.

[@ladybug5859]

Ernestine, Janet is right --you just have to get your mind set back but that's a little tricky. I will also say , because I forgot it during this made up crisis: DO NOT LET anyone tell you WHAT TO DO with your body, no matter what they indicate their intentions are!😤 I do not think that a lot of people who drank the Kool-Aid and took the vax-- letting people tell them what to do with their bodies- had MY initial reaction which was: NO way will they be able to create a vaccine that prevents infection and NO way can they do it rapidly. THAT was MY immediate thought-- without thinking and without knowing anything --but unfortunately I forgot MY GUT reaction . THE stomach is the bigger brain than the brain in our head tho its called the SECOND brain & SHOULD be called the FIRST brain, as it has more neurons than our mind & knows before our mind has pulled on its shoes👞👡👠 to start the🌅 day. I drank the Kool-Aid and I'm still having side effects from the vax, unlike my 2 brief, 12 hr encounters with the virus!😵 I do feel permanent damage does occur to the brain n the ❤ and even if I do NOT have the neurological symptoms that Sean has on this podcast or the cardiological symptoms that Kyle Warner has on doctor John Campbell's site, there are problems with my ❤ & i feel my brain's not as quick or acute as it was . I envy that you fell upon that one meal a day routine and your body was happy and I do pray you can return to that🙏 Use the second brain-- the mind-- now that Dr been has explained what your first brain-- the tummy🤗-- told u to do a while ago. GOOD LUCK🍀🍀🍀🌈

[@bobthrasher8226]

If autophagy peeks at 48 hours, then what happens during extended water fasting? Short term "starvation" will enable cells to dump their waste (intra-cellular action), but we know that longer term starvation can break down things like arterial plaques and also "remodel" damaged tissues (extra-cellular action). It would be great to get the whole spectrum of what mechanisms are active over these various "phases" of "starvation."

[@imagomichelle]

@@paulbarclay4114 and the re-feeding period is critical after an extended water only fast.

[@jeannettemostert2693]

@@paulbarclay4114 my longest fast was 23 days, broke fast evening of 24th day. Don't think i will embark on such a long fast again, but i wanted a total reset. I think a 3 day fast from time to time is very good.

[@lammilee1]

@@paulbarclay4114 How do you properly take supplements while on a fast? There are a good number of them that absorb better with food. First timer here (have done nothing past Intermittent). I had Omicron in Feb. VERY sick for 2 mos. Have had Long Covid since then...can't work now. I desperately want to do whatever I can to get this out of my body! Taking lots of notes. Loving Dr. Been's drawings. They help a lay-person alot!

[@CristinaCampbell]

You hit ketosis at 12h, human growth hormone starts to kick in at 15. Autophagy starts at 24 and reaches it's max at 36h. Growth hormone increases by 5x at 48, insulin is at it's lowest at 54h and at 72h your stem cells start activate. I got these numbers from Dr. Longo a couple of years ago.

[@kingandkongo]

„We know“?

[@ldpetchell]

I learned this from Dr. Ken Berry and other keto/carnivore docs over 10 years ago.

[@bobthrasher8226]

Also check into Jason Fung on this topic. He has done a good job of pulling together a lot of research on this topic but also making it practical.

[@debpratt52]

And Dr. Ken Berry. We've been doing Keto and intermittent fasting since Dec. 2019. It has done a lot of good.

[@ParallaxView111]

@@debpratt52 I'm not giving up what he calls B commit. Honey has 5 grams of sugar per teaspoon. I still listen to him.

[@debpratt52]

@@ParallaxView111 LOL! Yes, Dr. Berry does have some funny comments like that. I think he's trying to shock us. I feel so much better without the carbs, and arthritis pain is gone. I need to do better with the fasting window - I've gotten a bit slack, and can feel the difference. I do like Jason Fung, and also Dr. Cambell. I do NOT like my personal PCP, but here in the country, we have few choices.

[@jerryhenderson8923]

Domonic D'Agostino researches keto and fasting for NASA and Special Forces.

[@RoyBruce007]

What I've learned today Sleep while fasting. 👍🏽 love it

[@Frutyge]

There is a great group at Facebook where we practice this. We are suffering from LC or postV syndrom. Also there is surveys you can answer during the process to get more information. I think its a very good and supportive group. The ones in charge do also a great work. Best wishes to everyone. ♥️

[@chelseascott5872]

Can you add me to the group? I had issues with the vaccine and now that I have covid, I think I may have post viral fatigue. It's been a month since I got covid and I'm not improving.

[@Frutyge]

@@chelseascott5872 yes I will find the link ❣️

[@skinscapetattoo]

The more I watch you the more I love you. Your drawings are superb and you clearly have so much enthusiasm for your topics and research

[@spencerspratley7625]

Glad I discovered this channel. You put out some really excellent content. Thank you so much.

[@autopeep24]

Doctor Been such wonderful information. For someone to integrate autophagy into their lifestyle you must understand the mechanisms of satiety, the state of being full, and prolonging that feeling. Current FDA guidelines on diet is calories in calories out model, whereas a better understanding would be the hormonal control of hunger and what to eat to prolong satiety without being hungry. The current MyPlate guidelines on meals eating will cause someone to fail on trying to practice autophagy. Hunger always wins. Hormones like leptin, grilling PYY, insulin and others are more controlled by eating a higher fat and lower carb diet. This would be a great follow-up lecture to this one you just gave.

[@sstorm1328]

I think I have been doing this most of my life after the age of 16 or 17... Always had tons of energy all my life... I thought I was just being lazy about skipping meals..... Until I feel really hungry or a meal is offered conveniently....

[@lvee7569]

Excellent video Dr Been. I have been intermittent fasting to address chronic inflammatory issues and it's made a big difference. It's really useful to understand these mechanisms. You are a gifted teacher and explain things so clearly.

[@lam7750]

Thank you Dr Been! You’re so helpful to us ordinary regular folk who need such explanations so as to take good care of ourselves, since our healthcare system and our family doctors have no such inclination, as it would make us healthy and thus reduce their incomes and profits from big pharma! So thank you immensely and God bless you!

[@WidyaWalesa]

That's why we are told to fast, just like those before us

[@cherryb6105]

Loved this Dr Been!

[@samanthatorres9517]

I am a visual learner, so I love your visuals, it helps me understand the concepts your teaching so much easier. I love your humor, and your great enthusiasm for how we a wonderfully made! God bless you🙏

[@timothyburchett8306]

GREAT ANGLE!!! GREAT WORK DR. B.

[@jghk5866]

Thank you for what you do Dr. Been.

[@sarahjames4295]

Drbeen, I appreciate all of the detail in your videos! Would you please do a video on what stops/reduces autophagy?

[@hashtee3035]

You are such a great teacher! Thank you!

[@barbarafisher1749]

As always Dr. Been brings the greatest videos with so much information.

[@carollee594]

DrBeen you be the bomb of medical education and brotherly love. Please more on this topic with case studies too!

[@IesKorpershoek]

I'm on a 20 - 4 schedule, which works fine for me. 2 meals in the 4-hour eating window. First at 13:00 second at 17:00

[@WeighedWilson]

This video suggests that you might benefit from eating at 0700 and 1100 instead to benefit from autophagy in your neurons wile sleeping.

[@1shaymocha]

It's according to his or her sleeping schedule as well. I worked later hours so I had to tweak my eating times appropriately

[@mrpropre9206]

Loving the drawings, all the support from Luxembourg ✌️

[@bhagwanlaldangi4137]

Thanks dr been. Nice article.

[@jsteel89]

I'm so grateful for the love you put into your drawings. Thank you Dr. ❤️❤️

[@danielkriz9623]

Amazing. Thank you 🙂

[@teardropfloyd]

Fantastic. Thanks Doctor Been

[@dianedunncordle4824]

Thank you Dr. Been.

[@ladybug5859]

Thank you so much Dr been for this detailed clarification of intermittent fasting. AT first when I began it, when you first talked about this 4 months ago, my body immediately was happy and went into the mode of eating at noon and then not wanting anything until about 7. I did not know that I was not allowed to actually eat in between the first meal and the last meal but that was what my body wanted initially. MY body begin to shift after a couple months and I no longer felt simply the lack of desire to eat. SO I would take a sip of pineapple juice which I believe aids digestion and sometimes some fruit, although I actually never ate a proper meal in between the first and the last meal of the day. Of course the devil is in the details and now I know I better not sip or eat in between. OF course during the 16 hours stretch of no food I did sleep. I'm wondering how long one should sleep and maybe you will get to that but I'm guessing it's the usual amount of 7 to 8 hours. THIS is my last stop in trying to get rid of the continuing Cascade of side effects from the vaccine which began about 2 months after the vaccine. I've gone through a series of side effects for 15 months & the last one now is my skin is breaking out. Initially about 4 months ago I had a series of four times when my body would turn red and heat up REALLY hot and the fourth time it was as if it was burning and I almost fainted. I thought --Boy, I hope this doesn't carry on. I was at home so that was good. I read later that other people have had this side effect so I did not feel as scared from what might happen if it carried on & worsened. Instead it switched to a second skin side effect which Sean has talked about: I felt like I was being bitten by ants or some type of teeny creature and yet when I looked, there was nothing biting me. Recently that stopped and now I'm having the third skin side effect which I can only attribute to the Vax due to this series of things occurring to me. IT is a skin breakout. FIRST on my throat little bumps that had no color to them; then on my upper chest by my collarbone-- little bumps that had no color; and then a breakout of red bumps on my right side where my shoulder was and the collarbone and then it expanded to the left side so now my whole upper part of my body is covered with little bumps and they are visible especially on my left side of my shoulder and collarbone AND here I'm going to Florida🌊🏖🌦☔ for vacation! I know I'm saying-- Cry for me, NOT don't cry for me Argentina-- but because of monkey🐵 pox, I worry people will think I have 🐒 pox which can begin as a rash! 😳 IT'S been a month and definitely is NOT 🐵pox so I'm hoping that people won't look🙈 very closely & it will start to fade & if I go to the ocean every day and immerse myself for at least 1 hour in the salt water🌊 it will finally start to heal. I truly feel this is the third stage of the skin's reaction to the Vax & the body's way of detoxing. BY chance, I came across a place in County Sligo, Ireland where you can get seaweed baths that drain your body of ALL toxins in a very gentle but aggressive manner. I am thinking of going there if I can't heal my skin problem and am unable to detox on my own. It will be very pricey but i truly want this poison out of me!!😫😤😵 I do think the fasting helps but having heard the first part now of your talk, I think I NEED to do what I was instinctively wanting to do 4 months ago which is to increase it to 24 hours and then 48 hours. I will say tho that my body-- unlike at the beginning of my intermittant fasting several months ago-- does not REALLY want me to go without food so long so it will be a little tricky. I have taken the opportunity to write here on more than just fasting because I'm hoping someone else who has had the skin condition or knows of someone who does, can say-- DON'T worry, this too will pass and it is your body reacting to the Vax and trying to get the toxins that it created out of your body and this is the last step! I live in Texas and all summer it was 107° F and my AC was not working so I would be sweating in a 95° F home and then when I went outside it was 107°F and with great humidity. SO at first I blamed my break out on the extreme heat this summer and then later I figured it was both the vax and the heat but now that it's cooled off, I think it's just the vaccine side effect. SO m👼y blessed cool beens, if anyone knows of something similar, do tell. 🤗THX. AND of course I thank our dear Dr Been for all the work he does and the fact that he actually cares about people who are trying to heal.🙏🌠

[@micheleupchurch3725]

Thank you!💖

[@theb0ganator]

I drink long black coffee to kick start autophagy during my fast!

[@alm8bob]

Thank you 🙏🏻 I love your lectures. And I’m not even in the medical field. I wish I watched your videos before I decided what to study 📚 when I went to college.

[@pattiday431]

Not every professor expends the time and effort that Dr. Been does to explain the details. He has a special gift as teacher.

[@lcostantino7931]

thank you sooooo much ....yes have shared with many ...so easy to comprehend ..

[@c.k.1958]

thank you Dr Been

[@clives4501]

Brilliant lecture and I love the drawings. Seems that autophagy is a newish field for detailed research. Your comments regarding the possibility for cells, responsible for immune response, to be cleaned out while cancer cells may thrive as a consequence, is very interesting. Are there any studies which lead you towards that possibility? I would like to kill off the bad guys but not the good guys! I have been following the work of Dr Walter Longo and his fasting mimicking diet. He also sees the benefits of autophagy and your lecture explains in great detail the mechanisms involved.

[@johannagoanna8623]

A couple of years ago I read that fasting before having a chemotherapy dose was beneficial for the efficacy of the chemo. but maybe there has been more research since then that has changed that thinking.

[@clives4501]

@@johannagoanna8623 I understand that to be the case. However I'm not sure it is widely accepted by radiation oncologists.

[@lcostantino7931]

thank you,best motivation....

[@Kittens_Cats_Karma]

Thanks for the great info on autophagy, however life is hard enough without further torturing myself to gain few extra years to the geriatric end stage of life. As a coffee loving lacto-vegetarian I'm indulging the hot chilly and garlic saturated home grown chicory that supposed to promote health and prolong life span.

[@waggawaggaful]

Thank you for all you do. I’m very susceptible to all variants of covid. I had the first strain (devastating), then delta, then all the omicrons. I find that fasting helps me recover very fast from the omicron variants. I usually start the day with a coffee and eat dinner only. Or I eat breakfast, skip lunch and workout while hungry. Working out while hungry has been the fastest way to lose extra pounds. I feel comfortable in a bikini now and I’m loving it 👍

[@irinairina844]

Thank you

[@877swissmiss]

Loved this video😊, thanks!! I‘ve been doing that for a long time.( 1 meal a day- type) I think we all eat (western world) too much anyway and too often AND much unhealthy stuff..( processed food )

[@corny5128]

People have been fasting for health and spiritual benefits from time immemorial, it's nothing new. it's often tied to religious practices, most of which are vanishing as the world becomes increasingly materialistic and atheistic. Most religions contain moral and physical practices that improve well being.

[@youtubelibrary_10]

Exactly. All the adults in my family fast 2 times a month and every Monday in the month of Karthika (mid Nov to mid Dec) for Lord Shiva. Each and every one of these concepts are explained in great detail in Ayurveda, but to keep everything simple for common man, the rishis who taught Ayurveda figured out a way to incorporate these into our daily lifestyle in the form of "religious practices". The western doctors label Ayurveda as "alternative medicine" and yet, they take great pride in repeating all the Ayurveda teachings in English and take all the credit.

[@ramnathviswanath]

Nice lecture .

[@thegaryjay_yt]

that was so good

[@shericiancaglini8853]

I have done 20 hr fasts. I may try 24

[@docjan7812]

When do you then take all your vitamins when your fasting so long cuz it needs to be taken with food???

[@wattsobx]

Look into dry fasting

[@paulwolf3302]

I've been on an 8/16 schedule for almost a year. Lost tons of weight (well, pounds anyway lol). Also, the weight loss has been synergistic with exercise and I have gotten into great shape at the same time. I am an avowed "breakfast skipper" and eat my first meal at 2:00 PM. I drink coffee all morning, also take NMN and other supplements. Last night I ate a big bowl of popcorn around 9:00PM and didn't have any problem sleeping on an empty stomach. You just have to make a rule for yourself not to eat anything before 2:00 PM.

[@konungen68]

Takk!

[@southernskymn]

Thank you. I eat during an 8 hour window and I am going to shrink that down by a few hours now.

[@manavestnation]

You could have also included the subject of free radicals in regard to fasting.

[@EmakhosiniSiyakhuleka]

DOPE 🔥

[@bobthrasher8226]

Male and female ketosis begins at different times. Female is about 2 days while male is 3 days.

[@ParallaxView111]

That sounds interesting. What is your source? That might also depends on your weight. I don't have much weight to spare myself.

[@WeighedWilson]

Source please

[@lynnwilliams5432]

N of one comment 80 years and I Fast 72 hrs. My glucometer begins glucose drop and ketone rise at 35 hrs in. Evidently Dr Bosworth finds this common too . Great to know about night Autophagy. I am in great health no prescription still run on weekdays inside a gym where I sub ( retired biology teacher). I also do light weight upper body. Never had acetone phenomena but registering two above ketones common on feeding days and upto 5 on Fasting.

[@jonnes__4657]

Looking this video I get hungry. 🤔.... waiting for the next meal. What is the influence of coffee ???

[@nicholar1236]

I have been eating one meal a day for 3 years, occasionally I have a pie in the afternoon, otherwise no sugar, little fruit a ton of vegetables, pickles, eggs, beans, fish and wheat. That is what my body seems to love. I have no hunger; blood sugar seems to stay stable for 24 hours. I am 66 never been so healthy! So, the scientists just found this out, it has been known in the traditional health fields for hundreds of years. But I guess most of them were burnt at the stake.

[@randallhesse5011]

Intermittent fasting, to renew and refresh the mitochondria, (I hear). Their are two supplements I've found that are supposed to renew and refresh the mitochondria, methylene blue was one. I forgot the other, berberine maybe. Or maybe D-Ribose. ALA (alpha lipoic acid) as well.

[@ParallaxView111]

I have found when I fast, I usually get longer deep sleep on the third night. I could be getting 45 minutes on average, but on the third night I've had as long as 1 hour 50 minutes (1:50:00).

[@unclevaxx8530]

So for neuronal autophagy...OMAD, stop eating at 3 00 go to bed at 11:00 may be the optimal schedule.

[@Jean42ette]

I think this is why our Asian brothers and sisters who fast regularly look so much younger than westerners.

[@Maddie-lv5sg]

Dr., I saw a special on a man that was given a 500-calorie-a-day diet for several weeks. He had cancer and they"starved" cancer. Can you address this? I have done the 16/8 and my doctor was soooo excited about the results. Also during this time when I did start eating I got diarrhea, have you heard of this? It was like when I ate maybe the insulin output was too great to digest the food.

[@jameshyde1270]

Do cancer cells feed on ketones? Previous studies indicate that unlike healthy tissues, cancer cells are unable to effectively use ketone bodies for energy. Furthermore, ketones inhibit the proliferation and viability of cultured tumor cells. I am a avid follower of your presentations and thank you for your work. However I felt very strongly that your comment regarding my statement above needs your investigation. However I realize your agreement with the statement could be very harmful to you relative to the big Pharma regime see Dr Burzynski Cancer Clinic. Bottom line cancer cells need glucose but cannot survive on ketones. Fasting is a successful therapy. Thank you again for your work

[@Jean42ette]

I have been a natural faster of sorts - often not eating from 6pm to mid-day the following day and often just one meal, occaisonally a light lunch.

[@Itsme-jv4cd]

I wonder if fasting would help dissolve amyloid protein ? Like in ATTR-CM . Could there be a link in ATTR-CM and certain vaccines?

[@GM-bq6zo]

What's the general timescale for autophagy? Various professionals have suggested 17 hours, 18 to 20 hours, 24 hours, some saying it can take days. Some even saying slight intermittent fasting can trigger autophagy.

[@shenmeowzo]

Awesome talk. I want to try fasting to trigger autophagy to see if it helps with my vision, I have persistent floaters which I'm concerned might be the start of cataracs, I'm 43, pretty healthy, but need to cut out refined sugars. I'm willing to try anything to improve my vision. Might be a long shot, but have you seen any studies that suggest a benefit of this kind?

[@ladybug5859]

I have been taking 20 mg of lutein and usually it comes with a bit of xanthian and I truly believe this has helped. I began that routine about 20 years ago because at a food fair I met a young man who had really good eyes but they had started to give him some problems and he began doing that and he had no problems and needed no glasses. I wear glasses but I truly feel those supplements-- it's actually One supplement-- help maintain the current health of my eyes. MORE recently-- in the last 5 years-- I've met people who actually said their doctor recommended lutein and I was quite impressed since doctors know nothing about nutrition-- the exception of course of our leader of the cool beans Dr Bean. It used to be very cheap at the drugstore but now is a little pricier. I think it's because people have caught on during this 20 years, especially if their doctor recommends it, but I still think it's worth it. GOOD LUCK🍀🍀🌈🍀🍀

[@ladybug5859]

Oops!😳 it auto-corrected & misspelled: ZEAXANTHIN 2mg This is a plant that women in France made jam out of during World War II and American Pilots AFTER eating the jam had better eyesight at🌃 night. AND so it gained in importance although lutein I believe is the major ingredient of eye supplements IF you get the CORRECT ones. YOU NEED to look at the amount of lutein in the supplement before you buy it

[@shenmeowzo]

@@ladybug5859 thanks for the tip!

[@chark2718]

Enjoy your drawings too.

[@jennifereverett6298]

GOD bless you for helping the public in this manner, and I pray that many will support your work financially!!! I am certain that Jesus, our creator, is pleased that you are generously sharing your knowledge to benefit others.

[@1shaymocha]

Sir are you saying Reservatrol 💊supplement?

[@annahellmer5766]

Is autophagy by fasting also reducing auto-antibodies and microclots, or just crap inside the cells?

[@shericiancaglini8853]

How can one take supplements on a fast? Like vitamin D

[@himanshu-nl4yi]

What about suppliments and autophagy?

[@rentner1762]

Hm, I have been doing IF for three years now. 7/17. Unfortunately it has not resolved any of my issues. The only side effect is that I can keep my weight easier.

[@allencooke6794]

I have two questions/comments: 1. During autophagy when metabolizing fat, does the brain not need/prefer glucose, so is some fatty acid converted to glucose? 2. I have read a number of anecdotal accounts of how fasting cured or promoted healing from advanced cancer, but Dr. Been said fasting is contraindicated for cancer due to wiping out immune cells that were fighting cancer allowing it to proliferate.

[@jerryhenderson8923]

The brain works more efficiently on ketones. A strict keto diet is a very effective treatment for epilepsy.

[@allencooke6794]

@@jerryhenderson8923 I had read years ago that the brain required glucose whereas the heart's preferred fuel is fatty acid. So I was wondering how low does glucose go during fasting. If it goes to zero, then it seems it would be an effective way to fight cancer since cancer only uses glycolysis.

[@CL-he4jz]

@@allencooke6794 I remember hearing a phD doc woman lecturing... only wish I could remember her name... on how some cancers CAN change substrate and for eg use ketones or other energy sources, lactic acid for eg... so I gathered she was being moderate about recommending fasting/ low carb/ keto. Although they commonly gobble sugar. also learnt (elsewhere) that the brain's favoured fuel is actually fat... the fact we started eating animals created our big human brains, and that it wasn't even now thought to be the protein but the fat. when ppl hav alzheimers there was research on it being insulin resistance in the brain so they had high hopes for ketone (self production, or mct like from coconut oil or the exogenous ketone salts)... and it helped, but only in about 50% of cases. seemed when the brain couldn't use sugar any more the energy from mct or ketones could provide an alternative useable energy source, but in fewer % than they'd initially hoped..

[@smittycity42]

I've fasted for 24 hours before, but then had a really hard time falling asleep.

[@Itsme-jv4cd]

I always have so much energy when I fast that I don't seem to need as much sleep and thus I can't sleep as much.

[@smittycity42]

@@Itsme-jv4cd Yes, I have since some to find that if I don't worry about not going to sleep, then it's not really a problem, I get less sleep, but feel fine the next day.

[@robbie31580]

Diabetics should absolutely adopt fasting. Fasting will help to fix the insulin sensitivity problems that the person is having. I have a cardiologist friend who has diabetic patients that he has convinced to start fasting and their diabetes was cured.

[@tstricklin4808]

Agreed, IF cured my type 2 ,had to fight my doc tooth n nail ,all he wanted me to do is inject bayetta twice a day ,I finally told him no ,my a1c was 5.2 n had been there 6mo ,I had to use his data against him to get him to stop hassling me ,you'd think the first thing they'd tell you upon diagnosis is start fasting ,but that doesn't support big pharma or big agriculture ✌️

[@debpratt52]

True! Plus, give up those pesky carbs!

[@C0nstellati0ns]

I dont think we recycle every protein in our body every 3 months, that doesn't sound right. It's almost true for red blood cells, but not at all true for hair cells for instance. And that would probably invalidate every stable isotope analysis of collagen.

[@denisemiller6793]

Unclear...when in the terms of the fast should one sleep? If one stops eating at 7PM and goes to bed and gets up at 7AM is that ok?

[@tommyortiz6623]

Supposed to be 1 meal 2 hour window in morning like 11am then fast from that point. Late night eating is not good

[@bluemoon8268]

@@tommyortiz6623 ... no ... there are NO meals in the morning ...

[@Sonic_Shroom]

Does drinking milk with coffee and sugar count as eating?

[@lynnwilliams5432]

Hard to do rodents bc difficult to raise ketones. Me, n of one, 36 hr in great fall of glucose raise of ketones at that point.

[@realmiamiunderground]

It’s interesting that animals do this all the time when they are sick but we don’t consider it

[@lynnwilliams5432]

Grandchildren are begged to eat refused. Ahh good for you!

[@ThanhTran-et7ng]

How much spermidine or resveratrol is needed to induce autophagy?

[@GM-bq6zo]

Are there any supplements to repair or replace damaged mitochondria?

[@-astrangerontheinternet6687]

Exercise increases density and quality of mitochondria. Nothing works better.

[@GM-bq6zo]

@@-astrangerontheinternet6687 but exercise wont replace or repair damaged mitochondria will it, it seems fasting and autophagy is the only way to do it? The reason I'm asking is that I have tinnitus and its believed that damaged mitochondria could be the cause, but the only way to improve it seems to be fasting, more and more people are fasting to repair and get rid of tinnitus. I've read about things like C0Q10 and PQQ and how they impact mitochondria but not sure if they can repair or fix it.

[@-astrangerontheinternet6687]

@@GM-bq6zo Exercise will stimulate more mitochondria in each cell, and will also improve mitochondrial function. I’m trying to remember the source…

[@-astrangerontheinternet6687]

@@GM-bq6zo Please see the video “exercise prescription to maximize improvements in mitochondria function and content”

[@GM-bq6zo]

@@-astrangerontheinternet6687 thanks I'll have a look

[@CaLDwELLGoD]

This is why 21 day water fasting can heal the body like no other. People dont know this and so many people getting sick!

[@CoinsBand]

Dr Been is showing some weakness in his knowledge here. Autophagy from fasting has been studied for a long time and there are folks who practically base their careers on it. Autophagy in animals, especially animals with much faster metabolic cycles than humans (consider how many heartbeats a mouse/rat has). It may be quite a bit longer in humans to trigger autophagy. You might not even be in ketosis within 48 hours of fasting. By all means, if you're interested in this stuff for your health, go looking for more information and use this as a starting point, but don't just dive into 48 hour fasts (most people will struggle with that anyway) and don't necessarily assume you'll get the benefits discussed in animal models/studies within the same fasting window.

[@DrBeenMedicalLectures]

Just for koolbeens like you who will think I am mistaken I have linked the researchers' interview. And, I did mention that this work is going on since 1960s. Oh well.

[@LIFESaWONDER]

Using one's eyes and listening skills are imperative to discussions. Dr. Been is sharing his learned knowledge, which like the rest of us is done on a daily basis as we are not born with the knowledge of everything. He has listed the previous studies, and has spoken on fasting in previous videos. Be well~

[@jkmjemmadesigns5553]

Dr Marshal..The confusing thing to modern Americans is that in English the suffix 'co' implies a kind of equality...So the way it is said is not correct for the full meaning you describe here. Abreviating when it comes to the Mother of God is probably a mistake in the first place.( and just a note two posts seem to have come together I see comments to dr Kool Bean under this too!)

[@brianpancotto8829]

if you are mentioning this because of covid 19, the gut biome acid doesnt break down the spike protein so this method would 99% surely not work either.

[@clob1144]

How do you get rid of the spike out of your gut then will it just live there forever because none of our bodies processes are capable of disposing of it?

[@fillmorehillmore8239]

Going without is good. You will own nothing and eat nothing and be happy.

[@meggy8868]

Lol

[@debpratt52]

Haha! Good one!

[@susanfrazer8172]

Haha

[@lortarn]

Eat z bugs

[@Raj.Sakaria]

This guy is to Medical Research as Jordan Peterson is to Psychology.

[@degraham9198]

FBI. Holland. Smith. Calling me fat. Perfect example of harassment using a theme. Seemingly innocuous, but the pattern is apparent to the victim.