Mitochondria - Jodi Nunnari (UC Davis)

www.ibiology.org/cell-biology...
Dr. Nunnari explains that mitochondria are derived from prokaryotes and played a pivotal role in the evolution of eukaryotes. In an aerobic environment, mitochondria produce energy, in the form of ATP. This energy allowed eukaryotes to develop into complex cells and organisms. Mitochondria are also fascinating because they have retained their own genome and are dynamic organelles that communicate with other compartments in the eukaryotic cell.

[@MichaelHarrisIreland]

Thanks for the video, just an interested person in science in general. Seems we have plenty to keep us busy investigating and discovering in the future.

[@Elephantine999]

So they're not just the little kidney bean energy factories that I learned about 50 years ago. So cool to see how both they and our understanding of them have evolved.

[@romanowskiart]

Awesome Video, thx, if Back in school days you thought me biology, I Might have been interested enough to remember This stuff after 40 years...thx again

[@ErikS-]

Great talk! You really get taken into the subject by her enthousiasm!

[@michaelb1785]

I learnt so much from such a well delivered talk. Thank you.

[@rickhunt3183]

what an awesome woman. how lucky her students are to have her as an instructor.

[@stevenharrison2632]

Very well explained, thank you.

[@Placebo4FutureHealthCare]

Thank you so much for this easy to understand and visually rich teaching presentation! 💚

[@forest989]

Quite interesting talk. Thank you.

[@luli5851]

Thanks for your amazing lecture gives us so informative knowledge

[@Petrov3434]

Outstanding -- I am not at all an expert in this field -- but read all four Nick Lane's book

[@rsdaarud]

What a dynamic and essential organelle!!

[@dilipsinhjhala1713]

Very good information ! Thank you very much for sharing

[@jaydoyle1229]

Very interesting. Thank you.

[@sirranhaal3099]

NO PROBLEM

[@rickhunt3183]

She is a wealth of information.

[@isejanus2714]

Finally! A KZbin channel for Kreb's cycle enthusiasts!

[@ALASKAOO7]

bellissima lezione - i mitocondri hanno diverse analogie con i batteri: Contengono cardiolipina, possiedono un DNA circolare tutto loro; esprimo 13 proteine che contengono FORMIL-METIONINA, proprio come le proteine batteriche, producono melatonina "proprio come il batterio viola Rodhospirillum Rubrum, hanno una doppia membrana, sono anche in grado di metabolizzare piccole quantità di solfuro di idrogeno, uno dei primi substrati energetici dei batteri primordiali, e vengono riconosciuti come antigeni batterici dal sistema immunitario.

[@stefanbuscaylet]

Great job

[@subratprajapati1]

You very well convenienced us and I want a next level video on this from you..

[@evelyne7071]

During mitosis.....what happens to mitochondria ? Do they divide first, then get shared by the two daughter cells? Do they multiply once in the daughter cells ? What is the mechanism of their survival during cell division ?

[@gonicjon]

great talk...i take pqq for increased mitochondrial performance and energy production...i know i don't get enough sleep..., but what other health hacks do you have? i saw nad and nadh on your chart... i think i've heard it mentioned in other mitochondrial videos..... maybe some more citric acid to boost up/have available for the citric acid cycle

[@christopherellis2663]

I assume that there is a rhythm to their action that is concordant to breath. If so, then how one breathes affects their action.

[@variolaa1089]

Hi Jodi what happens, if you isolate people and poison their mitochondria with e.g. fluoroquinolones in respirators.... and the person doesnt have a chance to come in contact with other people and their mitochondria, so that they can exchange each other and repair mitochondrial damage... just like bacteria do it if harmed with transcription and stuff like this...? Thank you for this wonderful presentation.

[@erwinrogers9470]

Love it 🔥

[@GregMeadMaker]

Thank you for your wonderful presentation! What have you learned in relationship to the role that the ancient molecule melatonin plays within the mitochondria? -- Audrey

[@julioequinones]

Wow! How about in plants? Do they form this reticulum?

[@ascf2chen870]

Appreciated,

[@avidey7050]

Wow . Very well presented on Mitocondria in humans ! I am interested in finding opportunities for Clinical Studies for developing immune therapeutics for older americans. Examiing now links between Mytocondira Cross Talk with Gut Based Immune Cells. Any ideas for a Clinical Study Design coming out of Nunnari Lab ??

[@christopherellis2663]

Only 'older Americans '? Why not people?

[@fatimagafar4092]

As you mentioned that mitochondria in eukaryotic cell has different properties from the bacteria ,so how do we know the current mitochondria is from ancient bacteria ?

[@melissarainchild]

this "schematic"...linking al the metabolisms, is that available somewhere?

[@jonstfrancis]

www.sigmaaldrich.com/technical-documents/articles/biology/interactive-metabolic-pathways-map.html Similar one.

[@Pseudify]

For an interactive version of this see www.brenda-enzymes.org/pathway_index.php.

[@BLKCZARMEDIA]

I have mitochondria is there a way to keep from passing it on to my kids you know since it can cause dementia

[@peters972]

Mitochondria are colonized: like workers in a corporation, the perks make it worthwhile to specialize, however, the tools to be independent are lost.

[@Rimmonin]

That's what I was thinking as well!!

[@thefenerbahcesk4156]

21:15 What are the yellow dots?

[@marcdeckard7064]

Are these little critters aided by red or near infrared light?

[@alexciocca4451]

Molecular machines and these guys are the machinists

[@KlaudiusL]

mitochondria is the powerhouse of the cell

[@rajatmond]

Might-o- chondria

[@billdomb]

Find it hard to conceive we 'consume our body weight in ATP every day'

[@peters972]

That's 50g per min (ten teaspoons of atp) for a person weighing 150 pounds. Probably an active person?

[@esrefcelikcelik8789]

How could the ancient cells live without mithocondria before they ate(!) one?

[@stefanhensel8611]

There are other ways of generating energy - anaerobic, based on sulfur or iron - which bacteria use until today and thrive. However, iirc, ATP is the most efficient method.

[@rhyothemisprinceps1617]

@@stefanhensel8611 ATP can be generated by glycolysis - it is a product not a method

[@ketoonkratom]

Love One Another

[@maryruggere8146]

Of the eucariots only mammalian mitochondria exhibit maternal inheritance; nonmammalian mitochondria are not maternally so bound. I wonder why???

[@user-wz4nn4ii4r]

🤔 interesting thanks for that bit

[@KenJackson_US]

The mitochondria is indeed fascinating. But it's ironic to hear such a strong sales pitch for evolution using the organelle that so clearly demonstrates intelligent design. For example, consider the proteins. There are a *_lot_* of different proteins in the mitochondria. Proteins must fold correctly to be useful and they have to form the right shape and expose the right amino acids at the right places to perform their task. Did all of those proteins evolve? If not, where'd they come from? If they did, then surely there are a fair percentage that aren't quite done evolving yet, that don't fold compactly yet, or that don't fit together neatly with the other proteins components. What percentage of proteins in the mitochondria aren't done evolving? Many proteins have no value apart from being a component in a complex or machine. As the various proteins evolved, why did natural selection conserve them until the other components of the complex completed their evolution? Did natural selection see the evolving purpose? And as each complex in the electron transport chain evolved to functional completion, why did natural selection conserve the whole complex before ATP synthase had evolved into place? The fascination comes from the wealth of molecular machines and their protein components that all function so smoothly to perform such complex chemical processes and even proton pumping. The whole thing is amazingly well designed.

[@patldennis]

You're such a piss poor salesman for pimping creationism. Nothing you just said is incompatible with endosymbiotic theory. Go back to apologetics Sunday school.

[@itsReallyLou]

@@patldennis Wow! To me, evolution seems to be the religion. Occam's Razor tells me an intelligent agent designed this insanely complex machinery. Scary, right?

[@patldennis]

@@itsReallyLou Direct observation (an aspect of Occam's razor) tells me that the intelligent things that intelligent agents do are also always the consequence of physical brains. Occam's razor doesn't really lend itself to the invocation of supernatural agents anyway, so you might want to rethink that. Psst.. complexity can accumulate incidentally, and when people design things "for reasons" the complexity usually isn't a selling point but instead a necessary "it is what it is" consequence of having to juggle and compromise btwn various demands from within and without. It's almost as if declarations of complexity are Inadvertent admissions that "the designer" was constrained by aspects of its own creation. I guess that's why dogs can only sweat near their paw pads.

[@Beinhartwie1chopper]

Looks like Jodi could use a few more mitochondria

[@netto682]

👏👏👏👍🇧🇷

[@maxman9825]

Pls subtitle indo

[@denniscerletti9454]

Not all fatty acids are equal in energy production.Saturated animal fat produces 100% efficiency, mono saturated fat 115% due to the bond opening in the center is a easy snip, now you have 2 smaller sable saturated fats.PUFA's (polyunsaturated fatty acids) are highly oxidative and in metabolizing them produce toxic by-products.Omega 6/ linoleic acid has a 60% efficiency and Omega 3/linolenic acid has 24% efficiency. These heart healthy fats are anything but.Seed oils are damaging energy production from the mitochondria watch KZbin video's of Dr Cate Shanahan, Dr Michael R Eades, Dr Chris Knobbe, Nina Teicholz, Dr Paul Saladino

[@solohansan]

So, Mitochondrias are like midi-chlorians at «the Force»? Hey guys, do you want to train «the Force»? Learn about the mitochondria.

[@bodgertime]

I learned you can't talk about mitochondria without invaginated, must mean folds

[@Musketeer009]

An invagenation is a pocket.

[@akirataira6053]

So all by chance...........?!!!!!!!!!!!!!!!!!!!!!

[@Malkiore1]

Take a week off. Get online and order 4 things. A playstation 2 - a memory card for it - the game called Parasite Eve - the guide book to Parasite Eve. Then take some time and play this game. I promise you that you will love it.

[@nonyourbuz5805]

...cross your eyes ?...

[@jonstfrancis]

I assume it's a reference to 3d magic pictures.

[@NathanHaney-gj3gl]

Elon Musk wants to create the Borg on Mars

[@zizuwest1]

and evolutionists believe all this came from ...?

[@JonathanBrown1]

iBiology should remove this video. It is rambling and almost pointless. The presenter night have accomplished good science, but speaking coherent English sentences in front of a camera is a challenge for her.

[@keithhaken172]

🤣 bs A mathematical impossibility. Call me for an education.

[@hraqhraq]

very generic talk, and mostly about evolution, which is not certain science and un proven, not very useful video indeed

[@jamesgordon8867]

We didn't evolve