Ranking Isaac CHALLENGES By Their UNLOCKS

[@VECK88]

"april's fool challenge is fun" mfs when they remember that they have to fight the bloat on every floor

[@AnotherMattPlayingIsaac]

just skill solution 4hed

[@aggapuffin]

I would agree with you on April's Fool if the boss wasn't Bloat on every floor. Having to fight Bloat with base damage is rough.

[@tunafishpancakes1049]

Adding onto this first time I did this I was womb 1 when I popped a heirophant card that was randomized into a suicide king. That fucking hurt

[@CheesyCore]

​@@tunafishpancakes1049i got a no charge item that i spammed, it gave me blank card which activated my 2 of hearts that turned into suicide king

[@MenMagnet]

I cheesed that challenge with c section first treasure room and crown of light first angel

[@PROTO_BISMOL]

Bro April's fools I beat pretty easily I got tech x and did boss rush

[@Decatron76]

I just remembered my experience with that challenge. A couple floors in I used a use item, and since they’re all randomized, I got Damocles. The rest of the run was just me going as fast as I could fearing for my life

[@SentenceToDESU]

The only problem with "DON'T TOUCH" challenges is that you sadly eventually will need to touch them if you want Dead god

[@misirtere9836]

20:30 I COMPLETELY disagree with this assessment. It doesn't just "make Lazarus bleed more", *it gives Lazarus the item Anemic as a starting item.* What's the difference? Well, there's two relevant ones. 1. Since you have Anemic to start, it's taken out of the Treasure Room pool entirely, very slightly increasing the quality of those items. This is an extremely minor effect you will never explicitly notice and almost never happens, but it COULD happen before the unlock, and it CAN'T happen after. 2. *Anemic is a Range Up.* Lazarus starts with a low Range stat, and starting with Anemic brings it roughly up to par. While it is true that Range is one of the least important stats, the problem with it is usually that you get it from ITEMS, and you'd much rather have an actually good item instead. Starting with Anemic forever is free. It's like huffing a Range Up pill for free at the start of every Lazarus run, and while Range Up certainly isn't the best pill, you still love to see it, because pills don't have that same opportunity cost problem as items. Because of this, I believe the Unlock rating for Backasswards should be brought up to 4/5. It's actually pretty good.

[@smokeyasmr]

Do Right Now Challenges: 0:50 2 High Brow 2:49 6 Solar System 8:41 17 Waka Waka 9:13 18 The Host 12:32 23 Blue Bomber 25:30 37 Bloody Mary

[@lordofminddisorders5185]

Thanks brother!

[@gork2]

The solar system challenge pisses me off.

[@hellstar1237]

@@gork2still can’t beat it bruh 🫶🏼

[@gork2]

@hellstar1237 i read somewhere trying to use the blue fly as your only damage makes it alot easier, try that.

[@blackdust7353]

Dude, i'm somewhat new to Isaac (saw a lot of videos before) and did Solar System on the second try. But Bloody Mary took me over 7 hours, so i just reset for Placenta and healed me up each floor. Fucking hate that challenge

[@eagonwild]

note on april's fool: the pill that it gave maggy wasnt random, it was a speed up pill before repentance

[@AnotherMattPlayingIsaac]

ohhhh yea! you just unlocked some old memories of this lmao thanks!

[@anatawasukoshifakka9986]

​@@AnotherMattPlayingIsaacit still aint random, its a full health Fucking insane unlock

[@PROTO_BISMOL]

Full health for Maggie which Is good for sac rooms

[@RichConnerGMN]

​@@anatawasukoshifakka9986nice pfp

[@palladianaltruist8047]

@@anatawasukoshifakka9986no one said it was currently random, Matt had said it was previously random BEFORE being updated into a full health pill

[@TheBigYowza]

the BRAINS! challenge is actually one that I really enjoyed. I’m not normally a huge Bob’s Brain fan, but hitting an enemy with 3 of them in a row is so satisfying that it’s one of my favorites.

[@AnotherMattPlayingIsaac]

you either got some sick bomb synergies on your run or your own brain has been replaced with bob's brain lmao

[@TheBigYowza]

@@AnotherMattPlayingIsaac found pyromaniac in a crawl space on the second floor, most fun challenge of my life

[@yummygoy5138]

Interesting, now face the wall

[@sonicexer1856]

24:28 what on earth are you thinking not taking the finger on a challenge where you have 100 damage?

[@AnotherMattPlayingIsaac]

I KNOWWW lmao i was thinking the same thing when editing it my brain didn't even register it at the time

[@cataddict_]

i had an aneurysm when i saw that wtf lmao

[@plushysheep]

Shoutout to Card Reading for most Challenges. It cuts so much time and feels amazing in No Treasure Room Runs

[@sussusamogusbutthecoolone27]

btw you can easily clear rooms by just running into enemies since you have E. Coli and the "Oh Crap" transformation which heals you whenever you destroy poops :)

[@AnotherMattPlayingIsaac]

Ohhh yea I forgot about that bit! Just makes it even easier lol

[@lucassworldofletsplays9270]

It was harder back in Rebirth because the Oh Crap transformation didn't exist there​@@AnotherMattPlayingIsaac

[@No_Sleepee]

Note on Cat got your tongue: You may have to just go to mom, but the second you are pitted against a boss that isn't Dingle or Montro, and you might as well bind everything to your R key.

[@AnotherMattPlayingIsaac]

just skill solution them duh

[@lukeblaker8009]

Ok im here in the comments as the BRAINS fan, I have two dead gods and am working on a third and I just did this challenge for the third time and got it done second try (first run died in the chest). I dont think this challenge is that hard, it just takes a while, if youre comfortable with enemy attack patterns and such its not too hard to wait for an opening, what is important though is to not approach this challenge like you're playing normal isaac, cause bobs brain is a very weird item. Most people consider bobs brain a pretty bad item and in normal play id agree but in this challenge you can see how high its dps actually is when its the only form of damage you have to focus on. Honestly biggest issue with the challenge is some of the new rooms and enemies added in repentance in the cathedral, specifically the bishop has some very annoying rooms.

[@eduardohm5089]

That last image with the challenge number on the tier list, GOLDEN, thanks a lot for that.

[@dukedevilin2582]

oh my lordy lord 30 minute matt video christmas is early

[@happysaucey]

Backasswards singelhandedly ingrained the mega satan fight into my muscle memory

[@AnotherMattPlayingIsaac]

Honestly same lol it actually helps learn the fight by basically having to do it with base stats 💀

[@user-fs1lc2cj5s]

i got insanely lucky and beat it first try. never touched it again

[@stattickshark8112]

This is both entertaining and informative for a guy like me with skill issue or who only has mostly completed Isaac, Azazel and the Forgotten in other words

[@AnotherMattPlayingIsaac]

ay glad it could help! there are so many challenges that are just not worth anyones time lmao

[@Wooorbie]

hey it's not THAT bad if u managed to unlock forgotten

[@10Or106]

I still havent upgraded to repentance yet bc there's still a decent number of things that are just easier in ab+, like the forgotten unlock. If he did it in repentance, fair play, good for him. Otherwise, play az, hold r until pyromaniac, win run

[@MysticMicrowave]

Bobs brain is a very good item in the early game, especially if you struggle with alt path bosses because it's a boss killer. You can also got secret rooms and tinted rocks if you play it right, which is obviously valuable early game. It becomes an annoyance later when you don't need it, but I take it every time just for fun

[@danii7120]

I really like bob's brain! I dunno how to explain why but i just find it fun!

[@AnotherMattPlayingIsaac]

thats fair lol, if anything I'll give it props for actually synergizing with other bomb related items!

[@danii7120]

@@AnotherMattPlayingIsaac yeah dont get me wrong i understand why ppl hate it but I personally enjoy it

[@binno6727]

i think backasswords is a great challenge. So unique but not too weird. Challenging but doable since you can hold R for random items. I think its great you can use it too as a way to learn mega satans attacks and how to dodge.

[@AnotherMattPlayingIsaac]

for sure, its honestly the best way to learn the mega satan fight, since most of the time you're gonna be waltzing in there with base stats lol

[@G-Shroom-The-Mushroom]

Lazarus is Hella good now too what are you saying

[@No_Sleepee]

Note for SLow Roll: Swallowed Penny on Keeper is how you're able to stay alive during Hush fight. put that shit in top-tier

[@AnotherMattPlayingIsaac]

you're not wrong, but heck the keeper :)

[@No_Sleepee]

@@AnotherMattPlayingIsaac based

[@alarmy5211]

enough of the keeper slander, people from a year ago

[@Triflame.]

another thing is that laz bleeds more is actually a good unlock because anemic gives him bonus range which makes him equal to isaac besides luck

[@AnotherMattPlayingIsaac]

yea but i don't wanna get hit :(

[@Triflame.]

@@AnotherMattPlayingIsaac the range doesn't need you to get hit, only the blood trail

[@sasqule8321]

​@@AnotherMattPlayingIsaacYou don't need to get hit for the range up. It just gives it to you as soon as you pick up anemic.

[@Triflame.]

the thing about runes is once you unlock any rune you may as well do every other rune challenge because runes spawn as shards in repentance

[@AnotherMattPlayingIsaac]

that is very very true, you have a solid point

[@marcos62121]

Yeah im getting those shards but i still dont know what they do

[@Triflame.]

@@marcos62121 rune shards invoke a significantly weaker effect of a random rune you didn't unlock. they stop spawning once you unlock enough runes

[@pikminman13]

@@Triflame.that explains why I’ve never heard of them lmao

[@therealsammich]

4:25 chaos card is definitely one of the best cards in the game, just because you can literally oneshot any boss

[@Ant-fj2gx]

Blue/red candle is an absolute godsend for challenges where you're blindfolded. Helped me beat a lot of the challenges

[@ghhghggh249]

this actually motivated me to do some challs and get blank rune golden bombs and tech today, you could also do a tier list of achievments (excluding characters unlocks, challanges) that would be fun

[@AnotherMattPlayingIsaac]

ay glad to see it helps :) and definetly! i was thinking of something along those lines to tackle next as there is some pretty good stuff hidden behind some secret achievement stuff! appreciate the feedback :)

[@MigattenoBlakae]

⁠​⁠@@AnotherMattPlayingIsaac best examples of good stuff hiding behind a secret unlock are probably the halo and marbles. I’m sure those will end up rating high.

[@Spudbrainz]

Backasswards was such a pain to beat oh god. 5 hours of dying and resetting constantly until finally getting it, I was so extremely happy, and I really like Lazarus as well so it was a 10/10 to beat for me haha

[@siren_atlantica]

you're gonna hate me but I got it in like ten minutes on my third or fourth try without resetting 😭😭😭

[@Cheshire_Cat137]

It's so annoying just getting zero damage ups at the start, because it makes Mega Satan take forever.

[@Spudbrainz]

@@Cheshire_Cat137 real!!! But Laz upgrade makes it worth it!!!!

[@FadeIn2Obscurity]

Love the Wind Waker explosions in your footage. Your rankings are very well done

[@AnotherMattPlayingIsaac]

Ay thanks :) yea I love that mod too lol I've used it for way too long at this point

[@comradesocks7130]

April fools is a struggle mainly because of the cursed bloats

[@AnotherMattPlayingIsaac]

Yea I forgot to mention the bloats in the video :( my b lol

[@wolfpell4634]

Honestly I have April’s Fool to thank for my incredible skill against bloat, he’s one of the few bosses I can consistently nohit now.

[@kasm7870]

@@wolfpell4634While he becomes easy to no-hit (just sit behind him or angle shots), he’s still annoying to fight when he jumps to the top of the room and you play eyeball dodge simulator for like 10s while his jump is on Cooldown.

[@sasqule8321]

​@@AnotherMattPlayingIsaacHow?

[@cumcumcum148]

The first floor bloat is the hardest. Later it's a piece of cake

[@ItsTrixis]

Onan's Streak is so stressful, I found Binge Eater and Yum Heart and beat it with 2/12 hearts left still.

[@AnotherMattPlayingIsaac]

Edmund blessed your run personally 🫡

[@ItsTrixis]

@@AnotherMattPlayingIsaac and it was still close 😭

[@Peeingstickymilk]

Thank you!! Just got the game a few months ago and been wanting to start doing the challenges and wanted to do the best ones first to help gameplay instead of just ticking them off in order! Ain’t this the best game 😉

[@GbrieI]

AnotherMatt casually threatning me in the middle of the video as I sipped on my coffee made me almost Spit it out. *"You better do it right now, or else i'm going to find you."* - Anothermatt. That phrase just made me go from a *:)* to *:I*

[@AnotherMattPlayingIsaac]

LMAO don't worry its just a casual threat no need to go :l

[@GbrieI]

@@AnotherMattPlayingIsaac Too late AnotherMatt, I'm crying and i've finished all the challenges, Send *emotional support.* Also good news! i've Bought afterbirth and Afterbirth+! i dunno if i've mentioned it to you tho, afterbirth+ doesnt work due to my PC, but i'm Buying a new one

[@AnotherMattPlayingIsaac]

I'll call someone dont worry :( and rip that blows, your gonna need that upgraded binding of isaac machine

[@GbrieI]

@@AnotherMattPlayingIsaac Once i get my New pc, i'll grab your entire mods and go play Isaac with the most devilish grin in my face as my friend yells at me to play sonic genesis with him

[@CIoverleaf]

The oh crap challenge is basically tainted maggy introduction, since you turn enemies into poop, and the poop heal you

[@AnotherMattPlayingIsaac]

That's actually pretty funny to think about lol they are basically the same now that I think about it

[@tomasstargamer6308]

Pay to Play for Percs is insanely good, that is literally a top tier pill, Wafer for one room means you can just abuse Sacrifice Rooms a massive amount for angels and the big 10th sacrifice payout, for your question, it Is worth.

[@AnotherMattPlayingIsaac]

I agree it can be very good but idk if its just me but I usually pop a pill once i find it and never find the same pill again lol so I'll usually pop percs, then never find another one and am never really am able to abuse it. Now that I'm typing it it just sounds like a big skill issue though lmao

[@edualonsogonzalez9002]

I think you just put April's fools as way easier than it really is hahaha. To fight the bloat on every floor is really really struggling at the first floors, and to not beeing able to use actives and cards (or at least beeing recommended to not use them) since you can trigger suicide king or plan C effect, is crazy and annoying AF hahaha Loved the video btw

[@AnotherMattPlayingIsaac]

Ay thanks for watchin :) but the space bar item could also be death cert so anything is possible 😎 But yaaaaa I forgot to mention the whole bloat thing lol, should've definitely taken that into account but I'm dumb and forgor 💀

[@hopeatlast9617]

Weordly enough, I had a lot of fun playing Onan's streak. It was done in a few tries, and helped practice my aim and concentration. Baptism by fire was fun too. Now imagi'e my shock when I really... REALLY struggle in chamle'ges that you deemed extremely easy.

[@nottheavatar]

Breaking News: Isaac KZbinr spells Lazarus like a toddler sounding it out

[@AnotherMattPlayingIsaac]

LMAO

[@panfoo7718]

incredibly well made and easy to understand. thank you so much, this helped me pick which challenges to get to work on first

[@AnotherMattPlayingIsaac]

Ayy glad it could help :)

[@TheOriginalStarwalker64]

Duuude. The fact you were playing the Fez soundtrack in this. Based as hell

[@funkypengu1631]

Based youtuber using left to right to rank stuff instead of just using top to bottom, gives the list more personality 👍

[@AnotherMattPlayingIsaac]

based viewer

[@snaps_3398]

Glad you posted this. I just started to get back into the game.

[@AnotherMattPlayingIsaac]

ay glad it could help :) have fun!

[@kenji6492]

When I won the Brains challenge I ended up finding Gello and AAA Battety so I was effectively able to fight normally. Edit: Assbackwards gives Laz Anemic and Laz Risen a constant blood trail regardless of if you got hit or not. Much more worth it with the Laz buffs.

[@AnotherMattPlayingIsaac]

Brooo I wish I was you for the brains challenge, I struggled so much with it lmao

[@phgumerr646]

Holy shit I thought I was going insane by hearing nelward out of nowhere but nope thats his song in the background 9:13

[@AnotherMattPlayingIsaac]

bro that shits a bop ngl

[@orgil4152]

30:41 42 hot bombs . U can use active items called Red candle , Blue candle [ shop ] . When u using it active item animation will stops explosion count animation , use it just don't throw flame and sooner u throws flame bone dude starts explosion count . Candle give u control when bone explode plus u have ranged fire attack .

[@alexberube5269]

So fun fact about Onan's Streak. If you get Tech.5 then you wont have to shoot normal tears and missing wont hurt you

[@spikemedford3490]

Finally, the video I’ve been waiting for

[@gemstone4264]

thanks for the tierlist part 2, kept it on in the bg at work, made me want to play it when i get home U3U

[@AnotherMattPlayingIsaac]

Ay thanks for watchin :) glad my videos have that affect on people lmao

[@AlonzoJoséalbarado]

if anyone is still struggling with hot potato I got a few tips 1) active items that you can keep over your head (bob's head, the eraser, etc) will stop the countdown that makes the body explode until you stop holding the item, and when you do that the countdown will start from the top, meaning you can actually stop your ticking 2) since most (if not all) of the damage you deal comes from the explosion (that isnt really affected by your damage) you can leave behind items that only give damage over better options (like speed or hp) 3) urn of souls and purgatory are one of the best items to get, since you can use urn of souls with the body, thus preventing it to explode for free, and dealing a decent amount of damage, and with purgatory you can leave the body behind and just roam around the room releasing souls to their death 4) if you are confindent, dont throw the body until its close to explode and then throw it, doing so will make the body blow up mid-air and stop its trajectory, good for moving enemies or enemies placed in the middle of the room 5) devil deals are risky since most of them give damage and tears (both useless during the run) and take away you health, so avoid them and go for angel deals instead, since most of them give either hp or familiar, both that are really good in this run 6) hold onto any chaos card and use for the last phase of satan, since this one is the fastest one 7) the bible its better in this challenge, specially aganist mom's foot since it moves so fast and its really inconsistent most of these tips were fact-checked by me (except the last 2) while trying to beat the challenge, so I hope it helps someone

[@AlonzoJoséalbarado]

sidenote, your damage isnt that useless since when you throw the body to someone it deals damage on contact, but Its honestly not worth it if you have a better item to chose

[@thebugthatssnugpsn1911]

When life gives you Lemons actually made me appreciate the lemon active item. I just wish it was a one room charge.

[@silveredfred]

I think I’ve won the Delete This challenge 3 times, and on all 3 I’ve not gotten to blue baby once. After tons of resets due to bad items, only ways I’ve won are via winning early due to somehow spawning the trophy that’s supposed to appear at the end of the run early. Earliest I’ve gotten it is on the first floor, where I used my active item on the boss, it did nothing, but when I got hit, I blew up and a trophy alongside tons of pickups appeared 🤷🏽‍♂️

[@geo-fry6372]

Bobs brain carried me through ultra hard, so I now give it some respect. I generally don’t like using it, but I’ll argue that it’s way better than people give it credit

[@Fatomeki]

Having Jera as your only unlocked Rune when Blank Card still worked with runes was insane. You would get that combo so often

[@butters42]

thanks for this video i was debading on what challenges to do before this!! :)

[@AnotherMattPlayingIsaac]

Ay glad I could help :)

[@jacemerlin]

I found serpents kiss in a crawl space for hot potato and it made the run EZPZ, since you do a shit ton of contact and poison damage along with the bombs, and since you get black hearts with contact damage they drop constantly

[@AnotherMattPlayingIsaac]

that sounds like such a lovelier time than I had lmao

[@jacemerlin]

@AnotherMattPlayingIsaac youre gonna hate me for this but for ultra hard, i won by getting both ipecac and pyromaniac on the very first floor lmao

[@ItsSiWen]

I spend my time waiting till Saturday so I can watch Another Matt videos❤

[@AnotherMattPlayingIsaac]

❤

[@bottomtext9596]

In Red Redemption, every 5 rooms after running out of key charges another Esau spawns. If you get unlucky looking for the Mother fight you can have 4+ Esau’s on you (died twice there cause of this)

[@sup3rshockwav317]

If you hold down spacebar you will instantly use the explosive vest item making sure no enemies could ever touch you in blue bomber challenge and shredding bosses, I would move the difficulty to EZPZ just for that also it's like a two or three item run winner in normal runs

[@Vekomer]

24:27 BRO HE DIDN'T GET THE FINGER 😭😭😭

[@genericname155]

I adore your channel name I’ve never seen your content before

[@AnotherMattPlayingIsaac]

[@Xaun-dw8ed]

Another 30 minute rank video? The chores can be done another day 😎

[@AnotherMattPlayingIsaac]

Heck the chores 😎

[@Slushiecapital]

Been waiting for this video

[@AnotherMattPlayingIsaac]

Lol same tbh :)

[@mateusz12055]

Challenge 31 Backasswards might be easy if you restart a bit. I did it first try after a few restarts, so it being at 1 for struggle seems weird to me

[@AnotherMattPlayingIsaac]

I'm sadly hard headed and don't like holding R until a good run happens lol so that was based off my stupidity lol, if you just hold R until you have something decent to work with I can see your point for sure!

[@charwyrm8702]

I like Bob's Brain because it's an item I take for my ego. Any self damage is skill issue, and it melts early-mid game bosses. To have fun with it, pick it up on a high range run, especially with continuum or an infinite range item. Obviously it's cracked with explosion immunity, too.

[@meldoy60166]

is there a playlist for the music used in this video? or a list somewhere?

[@AnotherMattPlayingIsaac]

I do not sorry :( I pulled a lot of Nintendo music and stuff mostly

[@henrygeorge-2135]

Tip for Bloody Mary challenge- abuse the R key on your keyboard until you get a sacrifice room and a bunch of red heart drops first floor and pray for holy mantle or other god tier angle room item drop. Holy mantle is the only reason I could beat this challenge 😭

[@necksuss5806]

Fanny pack + a lot of hp ups made it easy for me. Dropped red hearts at the start of every floor thanks to the start of floor damage

[@YouravarageTBRplayer]

Tip for Cat got your tongue: Try to get Beth's faith trinket so you can actually shoot but don't rely on it too much

[@TheOriginalStarwalker64]

If Edmund ever does more updates, as unlikely as that is, I'd hope they decide to make some better rewards for the Afterbirth+ challenges. The literal hardest challenge in the game gives you diddley squat. Do they expect us to like that, or even encourage us to play it? No.

[@ceivman_]

I did all the challenges as soon as i unlocked them

[@AnotherMattPlayingIsaac]

That's fair lmao I basically never did mine at first

[@ceivman_]

@@AnotherMattPlayingIsaac haha lmao

[@kevinvieira2834]

Bob's brain is goated. Saves my run everytime

[@ashec.6824]

Just a tiny note about the unlock requirements for Darkness Falls: You have to have Sacrificial Dagger unlocked for the starting build, which means beating the Chest as Eve. Not sure if this has always been the case, but as of Repentance the unlock requirements should be: Darkness Falls: Defeat Mom's Heart 11 Times, Unlock Eve, AND Unlock Sacrificial Dagger (Defeat ??? as Eve)

[@dwfa8387]

Very good video! I just realized that you only hace 2k subs! What the fuck?! You deserve a lot more

[@AnotherMattPlayingIsaac]

Ay appreciate it :) We are slowly growing, I'm shocked I even got 2k lmao

[@MrGraae-dg5km]

It would be nice if you explanied what the runes does, so that it is easier to understand why some of the rewards are good

[@AnotherMattPlayingIsaac]

I'll keep that in mind for future lists! Yea i probably shouldn't assume everyone knows what every little thing is lol

[@KevCar518]

Yeah the video is basically useless without explanations of what each item does

[@Galaxy_Slayer3547]

i remember when i had to do onan's streak i ended up getting annoyed and restarting the run over and over until i got rotten baby, thought about it, then just used that and later on the finger for all of my damage instead of shooting lol

[@AnotherMattPlayingIsaac]

honestly i would do the same if the game gave me that lmao

[@glitchgaming1679]

For darkness falls, it's not just having eve unlocked if you buy rebirth and then add on the dlcs, you have to kill blue baby for it to unlock

[@glitchgaming1679]

Also the only time I would recommend using suicide king is in either the chest or the dark room if you have an extra life to use. I did it once and it was worth

[@Maraflor]

I attempted backasswards a few times before just holding R until I got Mercurius, made the run so much easier when you can just skip hard rooms.

[@jaredmckano]

Pre-Repentance, "Maggy Holds a Pill" game Maggy a Speed Up pill, not a random one

[@Simplifried]

As someone who recently just bat every challenge on one of my save files, I finally feel like I can have a voice in this video 💀

[@therealswitt4554]

What would you recommend for the greed donation machine grind? since while it's quite fun, I also don't want to grind 50 hours to get the unlocks.

[@anarchistpoops161]

I specifically waited finishing ultra hard before doing anything with samson, this is the correct way

[@samba1one531]

11:32 the worst possible pill at the worst possible moment

[@agmonblynkos]

I'm actually confused about something, are these challenges required for dead god? Since you say for some to just ignore them but what if I want to go for dead god, should I bother trying to complete them all or they don't count to it

[@AnotherMattPlayingIsaac]

Yea for deadgod you'll need to do them eventually, so you can just save the bad ones for last so they items you don't want won't show up on any other runs you do :)

[@GalaxicWolf]

Me who got the game yesterday and is hearing easy runs for things i have never seen yet 😅. I'll get there

[@33crest3]

I admire the float value rating

[@AnotherMattPlayingIsaac]

ima be honest I'm dumb and idk what that means lmao but glad you like it

[@33crest3]

1.5 rating for example number with point value is a float value at least in coding

[@33crest3]

I've just checked it and minus numers as -1.5 also does count

[@kayofarias9764]

note: in challenges where you cant shoot, such as beans! or cat got your tongue, maw of the void helps A LOT

[@DespacitoThree]

30:42 I cheesed this so easily by getting gnawed leaf. It made the soul take zero damage no matter what as long as I carried the forgotten or left him on the floor without using any items or bombing

[@szogun8904]

The only solution to backasswards challenge is to find gnawed leaf and sth to do damage for you when you are afk and prey that item that was taken from you wasn't that much important in later/previous stage that's how I beat this challenge (I rolled gnawed leaf and a familiar and left this comp for a night and when I woke up mega satan still wasn't beaten xD)

[@DanielMontenegroBass]

What is that wardrobe thing you have on the 1st room of the floor in the videos?

[@psycho3144]

what is tour criteria to put the challenges in the tier list? sometimes is the average and sometimes is the lowest property of challenge

[@skrill9765]

I have 97% in Isaac, and when I looked it up, i noticed i was still missing marbles. Such a specific unlock

[@lkz6654]

Oh man I got so lucky with backasswards. I had like six hours of attempts and only one had beat the mega satan fight. But eventually I started with booster pack on one run and it spawned a Moon card which I used to just teleport out of the fight. I was so overjoyed lol.

[@CsQ_RandomRepository]

The Brains challenge was hell; I only beat it with a pseudo-infinite health combo with Mitre, Book of Revelations and Habit.

[@pugdawg4787]

Gnawed Leaf made Hot Potato a joke. Not sure why but I was invincible the whole time I walked as long as I didn't throw the body. I just walked towards them and let it explode.

[@minothorine]

Oh god the adrenaline rush after completing speed is godly

[@Livecuhreaction98]

I love using bobs brain because of a mod that makes it some guys german Shepard laying down, if i get a bobs brain my day immediately gets better

[@CatsHaveEars]

Would have been nice if you told us what these items did or simply put a wiki of them on screen along with the gameplay.

[@Eshiiiii]

10:04 bc you unlock "Dads Key" and in that challenge your active item is dads key

[@BFDIFAN420]

Stud finder make you have a higher chance of getting a crawl space with a rock

[@ryanstoerger5432]

Any tips on blue bomber, I’m tearing my hair out trying to beat it

[@mork6668]

Scat man it's ultra easy,as you can run into enemies,transform them into poo,and poo heals you!!

[@AnotherMattPlayingIsaac]

Yea I forgot to note that too! Makes it even easier lol

[@cantmakeaname2689]

Bobs brain has crazy early damage, I always take it as a boss eliminator

[@noahlovotti7722]

Having any lesser good/bad effects of pills are good because it lessens the probability of picking up health down/tears down

[@AnotherMattPlayingIsaac]

You can say the same for health up/tears up though! But tbh it really doesn't make thaaaat much of a difference in the long run