Remyelination research in Multiple Sclerosis

[@donjerrard9370]

It’s very good to hear that there is research into remylination and very encouraging to MS sufferers like myself

[@__Wanderer]

had severe ON and haven't recovered after 6 months - I am considering doing a combination of fasting and taking clemastine for a couple months (the fasting to mimic metformin) combined with exercise to boost Treg - I can't wait another 2-4 years to maybe get some results. The research is fantastic and I am amazed at the ingenuity and dedication of everyone involved, but to a patient these results are still painfully slow. Surprised there is not a broader interest in remyelination as this would surely be beneficial to anyone over the age of 60 - perhaps assist in general cognitive decline for everyone not just people with MS. Thank you MS Trust + Dr. Nick, great interview. :)

[@marlenebean]

Wow this is so fascinating. I think MS research deserves way more recognition, the progress just in the past couple years is amazing.

[@DavidRivera-mr6pi]

gives me hope for my future years of life to see MS isn't being forgotten about

[@BernardAsagai]

Is there a study?

[@BernardAsagai]

Would like to join.

[@davidtrindle6473]

Interesting. Gold was used in treating Rhematoid arthritis. Perhaps there’s a connection to MS

[@genogeno1234]

Any research into cheap treatments for remyelination using Lion's Mane mushrooms? Animals have responded well and have shown regrowth of myelin, correct? Oh that's right...there isn't any big money like $125,000 per person per year in that kind of treatment. Never mind.

[@bobbivolz5849]

Do you know of any Clinical Studies for my son with Cerebral LEUKODYSTROPHY?

[@mstrust]

We are a multiple sclerosis charity and so this is outside of our area of knowledge. It may be worth contacting the MLD Support Association UK www.mldsupportuk.org.uk/ who support people affected by metachromatic leukodystrophy and will know what research is happening. You can also find a list of recent and current trials around the world on the Clinical Trials website at clinicaltrials.gov/ct2/results?cond=Cerebral+LEUKODYSTROPHY

[@vojkostar]

anything new on metformin/clemastine trials ?

[@mstrust]

The start of the study was delayed by the pandemic, but the first of the 50 people they are aiming to enroll started on the study in April 2022 (multiplesclerosisnewstoday.com/news-posts/2022/04/26/clinical-trial-enrollment-metformin-clemastine-myelin-repair-multiple-sclerosis/) The treatment will last 24 weeks, and the intention is to have gathered all the data by October 2023. There's a little bit more about the trial on the Cambridge University website at www-neurosciences.medschl.cam.ac.uk/jones-coles-group/ccmr2-a-trial-of-metormin-and-clemastine-as-remyelinating-drugs-in-ms/ and also on the ClinicalTrials site at clinicaltrials.gov/ct2/show/NCT05131828 (this latter includes the eligibility criteria)

[@novicailic6361]

this research has been terminated due to numerous adverse effects

[@mstrust]

An update of the five treatments mentioned in the video (as of December 2022): Bexarotene - the video explains why this drug wasn't taken beyond the completion of the initial trial due to is side effects, though the research did indicate that remyelination is possible - www.mstrust.org.uk/a-z/bexarotene Anti-lingo-1 (Opicinumab) - this trial was discontinued, not because of side effects but because the drug wasn't proving any more effective than placebo - www.mstrust.org.uk/a-z/opicinumab-anti-lingo-1-biib033 Nanocrystalline Gold - these trials are still ongoing, with results possibly appearing in 2023 - clinicaltrials.gov/ct2/show/NCT03993171 Clemastine/metformin - the Cambridge trial was further delayed by Covid but began recruiting participants in March 2022. It will be running throughout 2023, with results possibly in 2024 - www-neurosciences.medschl.cam.ac.uk/jones-coles-group/ccmr2-a-trial-of-metormin-and-clemastine-as-remyelinating-drugs-in-ms/