Renin-Angiotensin-Aldosterone System

[@SwOwW728]

Aldosterone actually will cause sodium to be reabsorbed in the collecting duct by the creation and insertion of more sodium channels, and this will cause water to follow and be reabsorbed as well. ADH will cause aquaporin channels to be inserted into the collecting tubule and cause water reabsorption to occur

[@deshantshah]

It also forms ENaC channel in the distal convoculated tubule..also aids in Na reabsorption

[@prateekbhunker2388]

@@deshantshah isliye neet pg tough in logo ki physiology jaha khatam hote h waha apni shuru Hoti h

[@muxsincade2520]

Ur right respect

[@rae2442]

My anatomy professor showed one of your videos in class and now I use them for studying and understanding the material for the exams! Thank you so much!

[@sibhare4775]

Fun fact, ACE doesn't actually "live in the lung" but in all blood vessels, most of the converting happens in the lung though because it is so highly vascularised

[@kameliasali9639]

But the kidney is vascularised better than the lungs

[@icepin6622]

this is lovely but it is adh that has an effect on the permeability of the collecting ducts causing more water to be reabsorbed into the blood. Aldosterone creates more sodium channels in the apical membrane of the distal convoluted tubule and then increases the activity of the sodium potassium pump in the basolateral membrane of the blood vessel. This causes k to be secreted from the blood and Na+ to be reabsorbed into the blood.

[@missnurse2be]

Isis Pinner ..and wherever Na+ goes, H2O follows by osmosis

[@eddiecervantes6735]

how about u make a vid

[@unfeignedfaith]

Ahhh...wow! You explain so simply...it's such a blessing to all nursing/med students! You're such a God-sent!

[@ppppp524]

Videos like these are why the internet is so freaking awesome

[@articwolf8377]

my nursing professor did a shitty job on teaching us this, and you made it so easy to understand, thank you so much!

[@MNVanny]

I love your videos they are short simple and precise. you help me a great deal when I am reading for my exams you save me from turning lots of pages, especially in exam fever mode. may God bless your work.

[@n01osteonz]

Thanks for this video, it's great audio quality and a very clear visual aid.

[@harpinmartin]

Hi, this is correct but very confusing for many people. To clarify Sartans are Angiotensin II receptor blockers that act on the AT1 receptor. Sometimes this receptor is called Angiotensin II-AT1 Receptor, to avoid this confusion.

[@فلانالفلاني-و5ك4ه]

I’m studying autacoids and idk what I would’ve done without you

[@mohammadmaazrahman641]

Love the neatness and handwriting

[@jadencook8505]

Your videos are life saving, thanks!

[@SoniyaJijil]

Well explained in easy understandable way. Thank you.

[@currentcharts567]

Yes - both vasopressin (same as antidiuretic hormone (ADH)) and aldosterone work to increase blood pressure and blood volume. But by different mechanisms. So, starting with aldosterone - this is released by the outer layer (cortex) of the adrenal gland which sits on top of of each kidney. Aldosterone causes increased sodium reabsorption into the blood and water follows it into the blood, thereby increasing blood volume and blood pressure.

[@iansleight5101]

and yes the release of Aldosterone does increase the re-absorption of Na+ so by default H2O follows. thus the body excretes K+ and absorbs Na+ and H2O in the presence of Aldosterone.

[@katelynlewis4192]

this just helped me with my Anatomy test soooo much!

[@danaq7307]

You r amazing thank you SOOOO much for all you doing for us this is really helpful and it does help me i have exam tomorrow you made my day ..keep going.

[@martync1988]

what's the little diagram next to BP up? I can't figure it out? Otherwise, this is the most clear and concise explanation that exists in the world today of this pathway.

[@fkrikela]

Aldosteron does not act on the collecting duct! It's on the DISTAL CONVOLUTED TUBULE!!

[@jimbojones40]

like this comment ppl its da truth

[@Idyllification]

Florentina Krikela it acts on both the DCT and collecting ducts..

[@missnurse2be]

Idil Truth! It acts on both

[@Cosine_Wave]

Florentina Krikela You should really provide a source...

[@adityarajasekar5138]

It acts in both 🙄

[@Nycguy3885]

Best explanation I have ever gotten.

[@SimplyPinoyNotSoRichRico]

I FUCKING LOVE YOU! I'd rather watch a 4 minute video about this and learn something. Than whole lecture of a professor knowing nonsense

[@windstriker5]

Aldosterone causes sodium retention which causes osmosis and ADH increases the water permeability of collecting ducts, right?

[@BiologyByteYoutube]

Wow this is great !

[@jhosnardi6731]

Just wonderful, I have been researching "dietary management of kidney cancer" for a while now, and I think this has helped. You ever tried - Aenarter Uncomplicated Assistance - (do a search on google ) ? It is an awesome one of a kind guide for discovering how to help your kidney function without the hard work. Ive heard some decent things about it and my partner got great success with it.

[@aleshamcconnell-carmony6938]

Your videos are awesome. I think Sharpie should send you funds for advertising their markers! If you had time, I think another video explaining which electrolytes are affected in the tubules, loops, collecting duct etc as well as how diuretics, ACE-I, ARBs etc also affect these areas as well. Regardless, you've helped a poor PA graduate with hopefully passing her boards very soon!

[@MohamedKAli1991]

This is so professional ,thank you ,and please keep going the good work and don,t stop

[@janumba90]

Everything is so clear. Thank you!!!!

[@cryolophosaur]

Great explanation, however it is ADH that aids in the retention of only water. Aldosterone aids in the retention of both "Na+" and "water"

[@thomaslam1117]

would like to ask a stupid question: wouldn't aldosterone also increase the reabsorption of Na+ and H2O in the distal tubule?

[@pranatithakur1182]

It does. This isn't a stupid question.

[@rhoelyncortez9879]

Yay!Mahalo for the well-drawn and well-detailed explanation.

[@BlkBeauty561]

Amazingly clear. Thank you.

[@vannesajeg726]

Very simple to understand thank you

[@maniagnihotri5136]

Video is good..it helps me a lot in my exams...voice thdi clear hti bs...

[@App4dat]

This was on point. Thanks for your time.

[@33rosas]

I never understood that when I was in college! I owe you!

[@TheSosita93]

Great explanation using it to study for my pcat !!

[@Koalaslovesloths]

Amazing explanation thank you! I needed the clarification and now I'm able to follow my chart more carefully. God Bless You Happy Easter

[@harryjoseph7172]

The RAAS system does NOT start with the liver’s production of angiotensinogen. It starts with the kidneys dectecting a decreased amount of perfusion which starts the secretion of Renin by the JXT cells, which then mix in with angiotensinogen and so forth. The name of this mechanism is also the order it follows as well, (1)RENIN-(2)ANGIOTENSIN-(3)ALDOSTERONE system.

[@gamerguy765]

Thank you! Concise and very helpful

[@vedelsticks]

lovely clearly explained video, thanks!

[@trinitheo1]

Love the work you are doing, you have my support

[@xhesi999]

I don't know who you are but I love you man thank youu

[@akashdeshi01]

thank you so much, I get intertwined in RAAS mechanism

[@deadeye519]

you should explain mechanism of aldosterone and which channel it upregulates (ENaC) so you can differentiate it from the effects of arginine vassopressin (AVP)

[@MasterThil29]

Nice video, sums it up really well.

[@Dhjdidndd827]

Genius ! everything in one simple handwriting !

[@xXAnthony619Xx]

Wow, thank you for taking the time for these videos! They're amazing!

[@jnkwan]

thank you so much! I finally understand the RAAS system!

[@SmellyElly01]

Great video! Quick question - you said that aldosterone acts on the collecting ducts of the nephron and this causes the nephron to retain water and this increases blood pressure. If the nephron retains more water then less is reabsorbed into the blood - so therefore how does blood pressure rise? You stated in your other video that aldosterone acts on the distal tubule (you didn't mention the collecting ducts) and you said it's action here was to increase the rate of water excretion? How can there be an increased rate of water excretion and an increase in blood pressure simultaneously?

[@2dazlious]

Beautifully explained!!

[@wethenatureenthusiastssa1736]

Great, explained very nicely

[@bhound]

Nice and clear and explained well conceptually......Thanks mate.

[@oladog]

Very clear and easy to understand. Thank you.

[@Kaurishan9]

Wow...very nice explanation 👍

[@krystalcastillo7767]

thanks for posting!! i'd been looking for a good animation about this to better understand it, and this definitely helped! :)

[@raniberry130]

Great explanation!

[@sukhwinderpalsingh1171]

Thats very concise and informative. plz keep it up for use of Doctors serving the ill Humanity world wide. Thanks A Lot.

[@croaker260]

OUTSTANDING...the only thing I had to learn in addition to your description is that it is the JGA in the kidneys that sense the drop in pressure and causes the release of Renin. Otherwise absolutely OUTSTANDING!!!

[@heyitsmedima]

regarding aldosterone, i know you're probably simplifying, but new students should not be confused. aldosterone makes collecting ducts retain sodium, while AT2 stimulates ADH release that inserts aquaporins in collecting ducts and makes water flow by osmosis back into the interstitium.

[@AnitaAnita-ns4yv]

Hey ! Great video, it helped me a lot ! Please upload the PDF drawing on ur website !

[@DJuggz06]

Cheers mate, bless you and youtube, much nicer than reading textbooks =)

[@Shweta-Sahani]

how drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) may reduce blood pressure. can you explain me about this topic plzzzz

[@RidaMalik1]

ANG II acts in the hypothalamus, where it stimulates ADH release and causes thirst!!

[@Sandra-eg7yf]

Thank you so much, this helped me a lot

[@mzhdakhalid3314]

This is very helpful thanks but i have a suggestion if u use more colour its more useful and become cool

[@zombiesniperify]

Thanks a lot good sir. Really helped clear things up

[@iansleight5101]

This would be a much greater video if it cut out the ACE drug info (maybe a brief mention of it) and focused on how this system is activated since it can become active in multiple ways. so if anyone actually reads these please make a new video that is only about the RAAS system. Its one of the most important systems in the body and deserves not to be overlooked.

[@studywithmeplease7604]

Really clear and good thank you!

[@habitualscholar9761]

Don't forget Aliskiren, a direct renin inhibitor. Great video though!

[@openparachine]

I don't really understand how the relationship between Vassopressin/Adiuretin and Aldosteron is. They both seem to effect blood-pressure, thirst and h2o-resorption in a similar way. I woul be very thankful for some clarity:-)

[@lucywhite9680]

this is an awesome video - thanks so much :)

[@sarikavishwakarma2235]

very good sir thank you so much.

[@TheKing-su1ze]

Thanks for this tutorial!!!

[@arinarakhteenko579]

Very easy and helpful!

[@denhyongotu3827]

Superb overview Gracías

[@nianmerza2539]

WHAT 'a clear explanation thank uuuuu

[@emanfathy1016]

Thankssss ,, it really helped alot .

[@stemi3384]

Great video! However, there is one mistake towards the end of the video where you state that Sartans can inhibit the cardiac and vascular remodeling. This is actually the only thing that Sartans CAN NOT do when compared to ACE Inhibitors, thereby making ACE inhibitors more effective at targeting the effects of Angiotensin 2.

[@Denisey411]

this guy is brilliant!

[@Jonnyiswhatweaimfor]

I like your drawing of the liver - it's cute

[@dr.khalidfarooq6864]

wtf man hahahah..ur comment LOL

[@prateekbhunker2388]

U need to take a break bruh

[@p_HoE_niX]

@@prateekbhunker2388 the comment is 6 year old you too need a break bro xd

[@TheArtistsupport]

does remodeling of the heart mean when the heart tries to heal the tissue, and creates scar tissue?

[@Sushil13]

Hi Tracie, From my understanding remodelling of the heart is due to pressure overload, I.e. heart works to hard to compensate. Once the remodelling of heart occurs it can not be as efficient which can cause significant problems. Also, once the heart muscle is damaged it can not be healed. Hope that helps. Registered Nurse

[@johnting1189]

There is something called low renin hypertension. How does this happen? Shouldn't low renin cause hypotension instead?

[@TheMandiCane]

I wish you could include ADH in this

[@maxx1669]

Thanks!

[@brittanyosburn2498]

That was awesome thanks

[@joannakero7247]

Thank you!

[@LukeJayden]

thank you good sir.

[@TheInspiry]

do you have references of this video?

[@HealthandBeautyEnhancements]

Great video!

[@syaffierasharif5441]

very clear thanks !

[@Sunny-ld4nn]

My God THANK YOU! It was explained so weirdly in my uni presentations that I felt like a moron for not understanding it!

[@alfajkhan2195]

Please provide pdf of your vidio.

[@DarkWitchofDream]

This was really nice, but I still feel confused. It's not like what I learned... Are RAS and RAAS different? I guess, what I'm trying to learn is more kidney/adrenal gland based?

[@purpleheart5837]

Yes they both are different one of them is Reticular Endothelial system known as RES & one is RAAS that is shown in the video I know it's been a year but I thought someone might have the same confusion.

[@DarkWitchofDream]

@@purpleheart5837 thank you! :) I'll be taking my board exam in a month so this is a great refresher!!

[@purpleheart5837]

@@DarkWitchofDream Best of luck to you❤❤😄at first I thought the comment maker might already have passed the class 😄😄but glad to know that it was helpful.

[@zahrah4145]

thank youuuu i can sleep now knowing i understand shit HAHAHHA bye.

[@TheWabster123]

cya

[@8-bitninjarobloxmore860]

very useful! Thanks much

[@prettyriich8059]

Thanks this video is great

[@sophiehourts]

This is FANTASTIC! Awesome job! Love that it is Australian as well, and not American with words pronounced oddly! Would be AMAZING if you did a tute for this series on the "Triple Whammy" (effect of NSAIDs, diuretics and ACE-I) - I have searched the internet relentlessly and never found one! Please please please! Thank you x10000000 for your fabulous videos!

[@esseyg5897]

HI Cathy, Please work on the volume of your you tube videos, It is very quite and hard to hear it with out earbuds or earphones. I like to turn on the your you tube while I m working around. I found it hard to hear it. SO please improve on that, otherwise I love your videos, very helpful, for my nursing program.

[@Abhishek-ou1gc]

This gonna help me in NEET 2021

[@mindofmyown333]

What other effects does Angiotensin II have on the body? I'm a little confused as to why letting the body make Angiotensin II and blocking its effects is better than using ACE inhibitors so that Angiotensin II never gets synthesized in the first place. Also, are the effects of the SARTANs localized to only the kidneys? As in if ANG II has other effects on the body, will SARTANs block all effects or just the ones on the kidneys? Thanks for reading!

[@NC-dk4mh]

I realise this is a year late but... blocking ace blocks angiotensin 2 production and aldosterone production leading to a more rapid fall in blood pressure than if you were to use an angiotensin 2 receptor blocker instead. the rapid fall in blood pressure could potentially kill someone especially if their heart is already compensating. As for the sartans I am still learning :)

[@schwartzenheimer1]

Also, suppressing ACE leads to accumulation of bradykinin, which in many people produces a chronic dry cough.