Rewinding the clock on aging blood vessels

[@hdthor]

This also explains balding in older men (not premature balding in 20yr olds). A good scalp vasculature is key to prevent miniaturization, since hypoxic environments promotes the impact of DHT.

[@Pedro-ds3cq]

This guy deserves all the funding he needs

[@AAA-of4vk]

indeed

[@theradicalaxe553]

@Capri Well he does eat mostly vegetables I don't blame him

[@urossedonja3534]

@Capri ha good one. i noticed that too

[@BurningDesire_letsgo]

You all think that’s gonna happen as it will decrease the profit that’s being enjoyed by big Pharma, creating jobs for people, hospitals, clinics, the taxes collected by the government, the economy will collapse!!!

[@Crispr00]

@Capri nothing wrong with Botox or dying one’s hair…I can see what you’re attempting to imply but this video had nothing to do with “wrinkles” or “graying hair” but rather muscle deterioration…so your comment is irrelevant

[@JA_Michael_]

David Sinclair is a genius, glad to share this world with him

[@Xgjigzigzyixiy]

settle down, this is a peripheral part of the aging picture. Light is more important than any other variable when it comes to health.

[@clincpb8903]

You are way to quick in calling plain salespeople a genius !

[@benabrams849]

@@clincpb8903 Read his book Lifespan...

[@michaelqiu9722]

How so? He seems like a garden variety academic to me.

[@oldsore]

Why doesn't he back any brands? Can anyone find higher purity or better pricing than donotage.org ?

[@partypao]

David Sinclair and his team should win a Nobel prize, not only for the research and discoveries they have done on fighting aging, but that he is openly sharing this new knowledge to the world.

[@CheerieTM]

I totally agree with you.

[@prat-man]

Not yet

[@user-fs8tl7ni1w]

Google: GlaxoSmithKline and David Sinclair. You’ll come to know more about David. A lot more.

[@espperre]

Essentially, increase NMN intake. I’d stay away from supplements unless they’re pharmaceutical grade. Foods highest in NMN: 1. Broccoli 2. Cabbage 3. Cucumber 4. Edamame 5. Avocado 6. Tomato

[@briansprenger5578]

You can eat all these things without being vegan.

[@cornstar1253]

@IAM REAL LOL. Every vegan Ive seen looks like a crackhead

[@angelhelen84]

Plus, contrasting showers. Going from hot to cold a few times.

[@hoofheartedicemelted296]

@J Wil It's not everyone's cup of tea J, but I started taking a Lemon Ginger Blast (not the tastiest thing in the world) for breakfast about 3 months now and I was completely gray hair and my locks and the back of my head is the original colour again, I'm not shitting you I'm being honest. I didn't notice immediately but people started pointing it out and some of my work colleagues even joked about hair colour products. I was due for an ear operation and as part of the pre-op set of tests they checked a number of things including blood pressure (high blood pressure runs in my family) and it had almost returned to normal and the mucus that was trapped inside my ear (eustachian tubes) was almost completely gone. They said they would go ahead with operation if it was my wish but added it was unnecessary given the new results. I don't have shares in vegan products and I don't really care that much who is impressed by me so there is no advantage for my to lie. Try it yourself if you are suspicious. The great Bruce Lee as asked how he was a genius given he was ahead of his time in his chosen field of knowledge, he said "I'm not a genius, I just try everything and keep what works and discard what is useless". So give it a try and be patient to let the results manifest. peace bud.

[@hoofheartedicemelted296]

@@cornstar1253 Then supplement with what they are lacking. If their knowledge is incomplete, then fill in the blanks. Don't choose 1 system over another, combine them and experiment and see what works.

[@craigherron536]

2:41 I started a regimen of 1g/day of NMN and 1g/day of resveratrol on 10/1/22. Within two weeks, the lower leg edema that I had been experiencing for several years completely went away. On top of that, my recovery time from daily pickle ball was very significantly shorter, and no more calf muscle pulls. None. I have been on the regimen for roughly two and a half months. I will never stop.

[@shanealharbi8664]

sweet man!! Super happy for ya! Any side effects?

[@Sh0n0]

@@shanealharbi8664 yes, one side effect my penus grew 3 inches

[@AL_THOMAS_777]

@@Sh0n0 Ol´braggart :P

[@AL_THOMAS_777]

Which BRAND of NMN pease mate !

[@RLLUMB]

Yes which brand do you use?

[@rahmann4280]

Quit eating sugar and processed foods

[@aregst]

no way to quit sugar and processed foods, cafes, restaurants etc. Most people live in cities. Life will be miserable (like in a lockdown, in a prison). That will kill more people than help. A multi-vector action from many institutions is needed to change the whole lifestyle of industries.

[@froesesp]

Quit oil, not sugar.

[@andyzhuang3946]

Start eating more organic vegetables and fruits.

[@ceraway2276]

I did, and somehow even that still isn’t helping the blood flow to my brain.

[@prat-man]

Quit life

[@sotoskaragianis3206]

Thank you dr David ,I just bought your book lifespan !you are my hero! Congrats !

[@luislehmann9929]

why we age and why we don't have to. i got it too, this guy mister sinclair is my hero. far from being hungry for profits, he does it so that humanity can benefit from his discoveries

[@ladoparts]

Thats very encouraging news and remarkable that a naturally occuring product in our body would be the catalyst that reinvigorates the others and reverses the condition

[@js.4758]

By watching ads, this channel gets more views & support. Tnx.

[@mcitheaterclass537]

Human bodies are an astonishing piece of engineering. Makes me all the more appreciative of the Engineer.

[@monnoo8221]

there is no engineer. It is evolution. Yet, in order to understand evolution.... well, i better stop, because it gets too complicated

[@c-4839]

The almighty God in his infinite wisdom,

[@monnoo8221]

@@c-4839 when d they understand that such nonsense is pure blasphemy, in their own system??? How can you apply sth like "wisdom" here' how can you say "almighty"? How cold you at the same time' It would mean that cruelty is an important part of wisdom. You are stupid, on your wn scale.

[@ETz-RYANH.]

Natural & evolutionary engineering in a way i write :)

[@jamesjirik2245]

Human bodies are incredible amount of maintenance unless you’re rich is a real pain in the ass

[@davidollen259]

David Sinclair you are a genius your theory on epigenetic aging would also explain the cambrian explosion of species as well as aging. Neat when one new theory explains an old conundrum.

[@Shells84]

This man has changed my life.

[@voidmap6628]

How, explain please

[@robertuk444]

The bold but ambigous statement you made does need some context, explanation and meaning, Please enlighten us?

[@markjones2453]

It's been 2 years I guarantee you see these comments EXPLAIN

[@bennyvarughese1582]

David you are a genius. A thousand likes for you.

[@ritahiggins139]

Thank you. Are there any other foods or herbs besides these that increase NMN? 1. Broccoli 2. Cabbage 3. Cucumber 4. Edamame 5. Avocado 6. Tomato

[@rogercobbs4297]

I admire such smart people you have a gift

[@DingbatToast]

Whenever I'm feeling a little too high on endorphins and the wonder of life, I'll come here and watch this video and remember how old I am and how much my body is decaying as I follow life's rut ever more slowly until I'm choked to death by the very systems that brought me life. Cheers 🍻

[@RIP5582]

DingbatToast Thanks Ding. 👍

[@Devonellah]

And yet you can't see the positive aspects to the research.... interesting... :)

[@theonlyantony]

DingbatToast ha! Yes!

[@DingbatToast]

@@Devonellah and yet you can't see the humour in my comment?

[@roybiden3985]

Before you hate for what I am going to suggest, please understand I am a few thousand miles away from you and there is no reason to hate me. I just would like to suggest that you read the Quraan . Its available online. May Allah bless u with good health and happiness in this world and thereafter.

[@farshm.7400]

Excellent work, Doctor. I'm rooting for you to make an awesome discovery soon.

[@soapfan2700]

Same here, if anyone can find a less invasive cancer cure or even better a dead certain prevention, then he can.

[@urielstud]

Dear David, Although I found NMN to be a rather strong diuretic that’s sometimes convenient, Nicotinamide Riboside seems to do the trick for me. It’s a little pricey so you can also try regular Niacinamide (Vitamin B3, Niacin) as a NAD+ booster. Along with Resveratrol, it may be the “15 year pill” here for us already!

[@lightbeingpontifex]

I do nmn nad resveretrol berberine coq10 and low dose niacin (super itchy and hot),,,

[@freespiritwithnature4384]

Hi Gricycle . Do you think this will work on the white scar tissue that is in the teeny blood vessel’s inside of the brain . MRI a yr ago there was some ,now lots . Have autoimmune disorder but what would you recommend I buy to begin with. Lasix is usually not liked by Drs because of diuretic effects, but would you with the Nicotinamide ? Where would I buy this / do you recommend a website ? I thought about Nitic Oxide. What are your thoughts?

[@orion9k]

Nicotinic acid is better than nicotinamid

[@skittles2055]

@@freespiritwithnature4384 hello dear Spirit, I don’t have specific answer but wanted to send blessings your way. Also, may I recommend Dr. Joe Dispenza’s work 💫 (meditations, books, lectures, testimonials/stories of transformation)

[@chunkycheeze1067]

Are you and Dr. Sinclair actually so close that you're on a first-name basis with each other, or are you just an American?

[@childcareinsights3100]

So many mice and rat studies show 5-amino-1mq and JBSNF-000088 will inhibit NNMT and combined with NMN will help achieve great fat loss. In practice, nothing happened with humans.

[@RightURKen7]

NMN = Nicotinamide mononucleotide- It's an over the counter supplement for those of you wondering.

[@shahin6671]

Vitamin B3?

[@UrbanClimber]

Or nad+

[@sandrastirling5840]

Wtf is that ???????

[@merson812]

Thank you do much.

[@jameslucas5590]

And how much of this NMN do you have to take for it to be effective?

[@xeropunt5749]

Omega 3 (Wild Salmon etc) Turns rigid "pipe" shaped vessels back into "hose" shaped vessels.

[@johnnyfly1236]

Or better use something that is not contaminated with lead and pcb. Like flax seeds, chia seeds, walnuts.

[@DARisse-ji1yw]

But... At my age, I'm happy to have a rigid pipe !

[@egreenie3819]

@@DARisse-ji1yw I thought I had a rigid pipe the other day😃. . . . . . . ...but it was just rigamortis setting in😔🥺

[@MoneyStrategiesSOULutions]

Johnny Fly : sorry not the same at all. You can get the purified ones.

[@xeropunt5749]

Avatar007 True. Calamari DHA purified is pretty good. Omega "pastured" eggs. Frozen Wild Alaskan Salmon burgers from Costco 480 mg of just the DHA, per burger.

[@eliosp3160]

So the question is, how does one improve blood flow of tiny blood vessels, as we age in a healthy sustainable way?

[@Broxine]

Taking opc

[@LifeDIY]

Cold therapy - look up Wim Hoff :)

[@LTPottenger]

fasting

[@EBIRCSBUS33]

take the herb rosemary the long lived in the blue zone use it on food hence better micro -circulation

[@Supportfreespeech]

I recently researched and found out that after the age of 40 people drop off about 50% in Nitric Oxide production which is responsible for softening the blood vessels making blood flow easier which in turn creates better circulation. To increase NO taking Beet Root powder and Citrulline will bring them back up to optimal levels that you can check at home with Test Strips bought on Amazon. Also discovered that many people are deficient in vitamin K2 not to be confused with just vitamin K. Vitamin K2 is responsible for proper absorption of calcium into our bones, being deficient causes leaching from the bones making the bones weak but the calcium then collects in our arteries (which harden) and kidneys restricting blood flow. Restrict blood flow and a host of problems are created. The good news is it can be reversed naturally. Studies have shown over a 4 week period after taking vitamin K2 the amount of calcification buildup was reduced considerably. So at the end of the day if blood flow isn’t restored over time and because some areas of our body take first priority when blood is rationed the others next in line either get less or none which causes small vessels to die thus causing nerve damage (neuropathy).

[@BillWilliamsChampionRide]

Thank you always David! The world and myself especially appreciate all you do.

[@jlushefski]

It's refreshing to see a scientist have a genuine interest in discovery in his field--though not that you can tell from this short video. There are other Harvard scientists, like Wrangham and Willet, who seem to be preoccupied with self-promotion, and science takes a backseat.

[@RobertColletto]

Not sure what everyone is using in terms of a brand, and I thought I share my experiences with NMN supplements. I have been using NMN for about 11 months, I am a 68-year-old male and I have tried over 20 different brands. The only one that seems to work for me personally is Probase Nutrition NMN Powder, simply because they are a well-known California brand, and I had their NMN independently tested for purity and impurities. Theirs came in at 99.89% purity and had zero lead in it. It seems some people on here have used Probase (the brand) NMN as well and they seem to be happy as well. Hope this helps!

[@DK-ox7ze]

He is looking younger in this compared to how he looks now. Wonder if the NMN and Resveratrol he is taking is actually working as well as he claims..

[@orion9k]

Resveratrol does nothing

[@DK-ox7ze]

@@orion9k Even NMN and NR doesn't do anything. I have tried them both.

[@orion9k]

@@DK-ox7ze what doses? Everybody on KZbin who does reviews on nmn says it works really well but there has been a lot of fake nmn products on Amazon as I've heard, maybe you had a fake product ?

[@orion9k]

@@DK-ox7ze I just got my nmn today, 15 gram ✔

[@DK-ox7ze]

@@orion9k From where?

[@almedogjurgji]

Always knew that M&Ms were magical 😋

[@kenouryios]

The calves are the second heart . Skipping makes the calf muscles really pump .

[@chrispayne750]

How are the calves the 2nd heart?

[@ShaunRL]

@@chrispayne750 Because the ass is the second brain.

[@swisstrader]

Huh??

[@laurieparis2203]

@@chrispayne750 the calves are the second heart, bc they help the veins return blood to the heart.

[@jenniferbeatty7545]

@@aqualane1 Train yourself to let go and stop caring what others think. Most would just think you're silly or crazy but screw what they think! You may free others by doing so ...

[@cherylnegus2441]

Great man. We owe him a lot.

[@cmac7243]

All the Tour de France winners: "They're still using rats?"

[@Darius-lh3ki]

@@donalkinsella4380 :DD

[@versewriter5856]

@@donalkinsella4380 😂

[@claudermiller]

LOLOL

[@aaronreeder5753]

@Alien On a Bike are you suggesting they specifically found elderly mice to trial this on? I'm pretty sure it would work no matter your age. They're too young? Wtf do you know? Lol.

[@ibperson7765]

Aaron Reeder Obv youre joking? Or... anyway the video said it only helped old mice.

[@ggfla6735]

Can you comment on the probability of NMN causing inflammation and thus being detrimental rather than beneficial.Thank you.

[@RA-qq8nf]

Any supplements? Any suggestions among the many brands out there!.

[@madchaos4912]

Yes it is called TRU.

[@tatsumakisempyukaku]

meygaag kabacalaf I think the drug metformin activates the sirt Genes, MTOR, and one other gene. All of which are fasting and exercise mimicking. NAD does something with that too. I’ve also read that reserveratrol is a fasting mimicker. If you want I can Point you to some good sources that I use.

[@versewriter5856]

Whichever one you choose make sure that it contains vitamins that are biologically available in other words 'activated'. If you'd like to know why then please feel free to get back to me.

[@tamuman93]

tatsumakisempyukaku - Please share your knowledge. This is fascinating.

[@tamuman93]

Verse Writer - Could you please explain what ‘activated’ vitamins are and why they’re important? Thanks

[@zainsyed9811]

Who is this elderly gentleman?

[@Shortwaveguy]

"With age, the body loses its capacity to make a key element of energy production called NAD (nicotinamide adenine dinucleotide) ... Past research also has shown that NAD is not effective when given directly to mice so the researchers sought an indirect method to boost its levels. To do so, they only had to look one step earlier in the NAD supply chain to a compound called NMN (nicotinamide mononucleotide) ... The researchers found a variety of beneficial effects of NMN supplementation, including in skeletal muscle, liver function, bone density, eye function, insulin sensitivity, immune function, body weight and physical activity levels. But these benefits were seen exclusively in older mice ... When we give NMN to the young mice, they do not become healthier young mice," Yoshino said. "NMN supplementation has no effect in the young mice because they are still making plenty of their own NMN ... Some tumor cells are known to have a higher capability to synthesize NAD, so we were concerned that giving NMN might increase cancer incidence," Imai said. "But we have not seen any differences in cancer rates between the groups." www.sciencedaily.com/releases/2016/10/161027122047.htm Source of NMN on Amazon: www.amazon.com/gp/product/B079S3XF4H/ref=ppx_yo_dt_b_asin_title_o00_s00?ie=UTF8&psc=1

[@crobinso2010]

Thank you. That was more informative than the video and took a fraction of the time

[@nantucket897]

John Linsky look at history it will tell you whose more violent.

[@asuraacademy2739]

You are good as gold 💯

[@GlossaME]

What's the role of Niacin in this?

[@madisonone8929]

Nicotinamide Mono Nucleotide (NMN) in DNA & RNA. The weird thing is they say you have to take NR or NMN etc to get NAD, you don’t. You can take full flush Nicotinic Acid (Niacin) & it converts minimum 30% into NAD. The more significant thing is to learning take Full Flush Immediate Release Nicotinic Acid. You start with 100mg & titrate to 1000mg or 1500mg to get decent NAD. I did this rather inconvenient experiment & now reached 1500 mg after great struggle that I do not regret one bit. Nicotinic Acid is life savior for me & my lipid panel has improved significantly.

[@Daughter-OfTheKING]

Madison One I was diagnosed with almost a 50% blockage in my carotid arteries and was prescribed 1500mg Niacin by my naturopath. My doctor had no solutions or treatment for me other than suggesting I “pop in once in a while and have my blood pressure checked.” If I was not warned about the severe flush I would have ended up up in the ER. Scariest and the most unpleasant experience. Needless to say after a while I stopped taking it because of the flush. I will try your approach. Thank you.

[@marieholoub4084]

I have tried to take it many times at 100mg but each time without a fail I get headaches....

[@madisonone8929]

Yvette - There are numerous strategies to taking Nicotinic Acid. You need 32 Oz of water, apple sauce, quercetin 500 mg pill & fish oil. After dinner go for walk then an hour before bed pop quercetin after 20 minutes follow by Nicotinic Acid pills, fish oil with Apple Sauce, squeeze packets are convenient. Drink first 16oz water when you experience initial tingling of flush then you drinking the other 16oz get the Nicotinic Acid moving. It takes 1.5 hours to fully move it after you swallowed. Also eating salad with dinner helps salads have quercetin which suppress prostaglandin d2 that causes flush. But flush is good, that’s when the body pulling out all the bad cholesterol out & boosting HDL. After a certain time you won’t experience flush & then a day off Nicotinic Acid & get back on it. The flush will come back. Flush is the secret to long healthy life. It’s not an allergy. There are no known case of anyone dying from flush. But this is something you have to titrate into slowly. Nothing to be panicked.

[@Daughter-OfTheKING]

Madison One thank you so much for taking the time to respond. I will definitely consider your suggestions. Much appreciated 🙂.

[@Daughter-OfTheKING]

Donal Kinsella I have not tried but I will educate myself on it and definitely consider it. Thank you

[@Dabayare]

When is that tooth regeneratig gel coming out?

[@nerblebun]

Dabayare: The patent was most likely bought by a group of wealthy Dentists, and sits on a shelf collecting dust....never to be released. The money is in the treatment, not the cure.

[@Ashok.Vaidya]

Dabayare it call Vitamin K2

[@pikiwiki]

this is what i'm waiting for

[@gf4353]

Yeah, what ever happened to it.???

[@Dogbertforpresident]

It would destroy the dental industry.

[@Janie77-2]

Which brands do you recommend and dose? Thank you for your reply.

[@traceylafontaine8893]

No mention about having a high acidic blood versus a balanced ph alkaline blood. 🤔 acidic blood cells are known to be linked to a long list of ailments.

[@hadd5106]

How do you know that the blood is acidic? Do you do a lactate test?

[@raydematio7585]

This is superstitious nonsense

[@funny-video-YouTube-channel]

Which foods have NAD+ and NMN ? Do we need to eat pills now, or is there any food that has those ?

[@MamaRestInPeace1424]

September 2022 big studies are out! Glycine and NAC given together even at doses up 10-15gm daily had very impressive results, no patients reported any side effects. How both work together was a surprise, the the many research studies concluded they work, and well.

[@Czy_dni_do_konca]

1can you please share this study?

[@stilllearning7434]

Here is the link to a small study of 8 older adults By Baylor University. Thanks Caleb Veloz. www.ncbi.nlm.nih.gov/pmc/articles/PMC8002905/pdf/CTM2-11-e372.pdf sorry, but is free and copy and paste works

[@larsnystrom6698]

@Caleb Veloz The way NAC (N-Acetylcysteine) and Glycine works are as precursors to Gluthathion, which is the cells most aboundant antioxidant. The level of Glutathion is reduced with age. So it's probably good to try to keep it up. To supplement with these two precursors is more efficient than supplementing with Glutathion itself! It wouldn't suprise me if Glutathion would keep some of the NAD+ consumers in check. Anyway, it can't hurt!

[@sukeshjph]

I've started NMN supplements recently along with TRT hope things get better.

[@cleopatracassar3716]

Love it! Thank you, dr. SINCLAIR !!!!!!!!

[@SandyCheeks63564]

isn't NMN the same thing as niacinamide? Except for the price tag of course

[@annmcneal7804]

It is- so let it be available for all!👍🏻😀😃

[@niftynan2081]

NAD 600mg caps gave me horrible headaches. Switched to DMG, no prob, then I started taking TMG 1000mg in morning and 1000 mg in the afternoon. It's helped me so far.

[@orion9k]

Why tmg? What it helped with

[@larsnystrom6698]

@Nifty Nan The reason to take TMG (TriMethylCystein) is usually to supply the body with extra Methyl groups. When the body gets rid of excessive vitamin B3, it consumes Methyl groups. (>Reference Chris Masterjohn). The Glycine is just an extra bonus if you also take NAC. Taking NAC usually doesn't cause any problems. But it's just the Cysteine you want. And if you get enough from your Protein, maybe that's enough. The research has so far been made with very high doses of NAC and Glycine. Suprisingly high doses! It would be nice to know how much you really need. I'm beginning to suspect that much of the problem with Glutathion is caused simply by older people not getting enough of protein. They might need 1.2 g/kg bodyweight. And not the RDA of 0.8 g/kg.

[@crand20033]

What about vitamin K2 ? Does this not help to prevent heart attacks/strokes and restore health to arteries?

[@dawnwhitehead]

Absolutely! It directs snd keeps calcium in the bones and teeth where it belongs instead of in the blood where it turns one to stone by stiffening the arteries. This in turn causes strokes snd heart attacks!

[@TheBadboy536]

Wow.. This is great news. David You are great !!!

[@RasheedKhan-he6xx]

I have read / been told about so many medical breakthroughs at the research stage. I even saved or scrap-booked the ones that interested me. Over 20 years, not one has actually helped a human. I really don't understand medical research. I think publishing papers is their sole objective.

[@baruchgedalia5271]

Will this help resolve an arterial aneurysm?

[@CraigKeene]

“Health is wealth.” Virgil

[@aldilee51]

Can we substitute nmn with niacin?

[@cowgirldepot1234]

Dr. Sinclair, Does this research tend to confirm the efficacy of EECP as well? It certainly improves exercise tolerance by mechanical assist to blood velocity, stimulating angiogenesis, and soothing endothelium as well. Have you looked at it's effects on NAD?

[@TopVillain]

He isn’t answering question

[@sleepinglaffey3886]

It's probably synergetic on senescent myocytes. -Meat based KD sprinter

[@sotoskaragianis3206]

I am looking to buy NMN. But are many companies ,afraid that can buy a fake product ,can you tell us a couple of co you buy ?

[@richardmiddleton7770]

Amazing what botox and 'back to black' hair spray can do!

[@littlekimmy676]

lol!!

[@v.r.2834]

Yes, indeed, I just taught that he used some „ help“ on his face and hair 😂

[@Lance2773]

The hair is brown.

[@devonbrockhaus6554]

Any worry that increasing SIRT1 would be potentially carcinogenic?

[@sheriu7167]

What are the medicines available now for this?

[@PotBotorg]

Awesome doing a gram a day. trying not to die till after 3020 . thanks!

[@PotBotorg]

@God 2 God the only thing I need is health happiness and love. Without any of those life ain't worth living . To those three things I'm addicted

[@abyssmanur3965]

Weed dilates the blood vessels, works for me ...58 and going strong, strong enough to take up gymnastics.

[@tamuman93]

Patrick Foley - Al Gore invented this thing called the Internet. It’s wonderful! You might get a book and research it! You’ll be fascinated. 😁

[@robertgoldstein52]

Another useless Md

[@sfguy2000]

@@pbfoley amazon

[@LBJTV]

Uploaded on 3/22. Nice touch. Genesis 3:22.

[@18782.]

Any update from the clinical trials?

[@laurieparis2203]

@@markobabic487 Thanks! Looks like they moved the completion date up to June 1, 2020.

[@ipponsuki]

Yes. Intermediate fasting and dark uncooked greens.

[@klam77]

@@markobabic487 how do they ADMINISTER the Nicotinamide Mononucleotide

[@bsxboy]

@@markobabic487 Marko, od kje prihajas?

[@MigsWasHere]

What about now?

[@monnoo8221]

risk factor number one for damaging micro vessels: chronic dehydration. number two: deficiency in potassium, number 3 : glucose. Without getting those in check, NMN can do only so much

[@ryanmckenna2047]

Niacin (which gets converted into nmn) naturally occurs in Broccoli and Cabbage. The average vegetarian isn't living exceptionally longer than anyone else. I think it is less effective than is being claimed by people who have a vested interest in profiting from the boom in sales their hype generates

[@aysha6725]

Am taking Nmn nearly Month but I notice my arthritis pain come back I am 35 years old women please advice

[@RodCornholio]

Any theories why NMN increases the vividness of my dreams?

[@Cherub72]

this stimulates cell regeneration as well and helps red bloods cells. I'm guessing you're able to get more and process more oxygen using this

[@RodCornholio]

@@Cherub72 OK

[@sabyasachisen5351]

FANTASTIC WORK.HOPE THIS WILL BE AVAILABLE TO US IN INDIA WHEN I AGE!!!

[@EFChartley]

HUGE EXPECTATIONS FROM USA 🇺🇸

[@robertmitford5329]

And 🤓??? 🤔 what’s the fringing solution 🙄🙄🥴

[@ldld64]

I know right ! I was waiting for it , BUT THE VIDEO ENDED !!

[@OneironauticalOne]

He said it, NMN supplement. It boosts NAD levels and helps improve muscular blood vessel growth in older individuals.

[@digimom82]

@@OneironauticalOne what is MNM?

[@OneironauticalOne]

@@digimom82 nmn nicotinimide mononucleotide google it.

[@emh8861]

FASTING and its FREE!

[@seanschmidt6070]

But,the paper published in 2016 mentioned CD38 could reduce NAD+ And NMN

[@g3tm0ney88]

I love mnm”s with peanuts

[@davydiver]

😂

[@colinmaharaj]

As expected

[@tonyneillaw]

Good joke, but he he clearly meant Eminem, the rapper!

[@orbs1062]

🤪 And I prefer plain.

[@klam77]

OMG Nmn confused with mnms. It reminds me of old commercial:" I said I wanted a bud light" intern: " you mean not bulb light.?!"

[@ainsleyameerali7622]

My question is .. if this nad is increased. .. is cancer in our cells increased also ?

[@pallabbasu4474]

There is a possibility, unfortunately !

[@ukidding]

and what natural foods contain these special molecules?....the good doctor's point of view caters for the pharmeceutical industry

[@Spark-In-The-Dark]

ukidding, of course he does. Harvard “elitists” aren’t trying to help the general population. They think we’re cattle.

[@tazboy1934]

Keto plus IF

[@wrchmura]

Edamame broccoli cabbage cucumber avocados and tomatoes

[@megaswenson]

@@tazboy1934 Precisely what I was thinking,

[@T9RX3]

It's called exercise.

[@yorocco1]

Why is NO ONE addressing recent studies showing that NAD can shut down methylation?

[@AniKulkarni]

NMN and resveratrol are seen to affect health positively and do reverse aging. Since no healthcare company wants people to live a healthy life (how will they run their business if that happens), I think one of them bought David's company and never used his work publicly. I started taking the combination recently and seeing very good results. Especially, NMN is boosting energy levels very effectively. I think the results might vary from person to person.

[@brandonsballing826]

If I remember correctly it was GlaxoSmithKline but the reason why they never used the design was that it was synthetic resveratrol that Sinclair tried to patent but the synthetic resveratrol caused kidney damage and the patients actually died in the clinical trials so they shut down the 700 million company after the artificial resveratrol death but natural resveratrol from grapes doesn't cause this which is what he now currently promotes.

[@roygarciajr2008]

What is NMN, pls?

[@sleepinglaffey3886]

​@brandonsballing826 Good God. that's why I don't touch hydrogenated k1 containing stuff or linoleic acid! Why would one want to ingest hydro vitamin K1. just like this SRT resveratrol analogue? Hell... why not just get resveratrol in liposomal form instead? -Meat based KD sprinter

[@valeriehopebennett]

MOST GRATEFUL DEEPLY APPRECIATED

[@zteaxon7787]

Sounds great. Amazing work! But it will likely have side effects that need to be watched out for.

[@loveinternet100]

Great works! the best Resveratrol and NMN is coming out now.

[@haroong.c8906]

So beautiful, thank you professor for this amazing information.❤️

[@T9RX3]

What are you going to do with the information?

[@annetteyoutube742]

@@T9RX3 Dr Patrick will surely tell you 😘 She's interviewing this doctor: kzbin.info/www/bejne/a3XXiKSwltF4pMU

[@LemonWatermelon]

David Sinclair should get all the clearances and funds to speed up large scale experiments and research..

[@Banjo11]

Would this also help in people that are already physically fit? Would they be able to perform faster and/or stronger?

[@Elayman1]

NMN supplementation didn't do anything for young sedentary mice but did boost exercise capacity in young mice that had been exercising regularly for a month.

[@popothebright]

And does NMN accelerate cancer? The jury is still out.

[@billmanhillman]

So the answer is more medicine??? Medicine is treatment, not a cure. Show me someone who finds a cure, and I'll show you a real doctor.

[@azycray4801]

There is no cure for aging, but you can slow it down. If NMN is made by the body then I wouldn't call it medicine, perhaps supplement would be a more accurate term. There are many supplements you can take to slow down aging. NMN is one of them which is fairly expensive. But what the hay, you can't take it with you so if not well spent, at least not wasted. I consider it an investment in quality of life.

[@Dogbertforpresident]

I think geneticists would have to find a gene (or make one) that allows our cells to produce NAD at the necessary level to remain biologically young. That would be a cure.

[@annabelalford804]

@@Dogbertforpresident the NMN affects the epigenetics of your mitochondria in your cells. So, it turns off or on certain genes that make you age. So....

[@jeremyanderson6789]

There is a cure for aging!

[@jackgoldman1]

NMN no longer available as a supplement, per FDA regulation.

[@AL_THOMAS_777]

FDA always wants us folks to die v e r y early . . .

[@549BR]

Elena, I took even more, and I haven't even been born yet; I'm just a twinkle in my fathers eye.

[@Android.Paranormal]

This could be major break through for Raynauds too!

[@catman4471]

I take NMN and experience phenomenal results that I don't see reported anywhere else, such as white hair restoring colour and was wondering if this might be because I'm also taking Isosorbide Mononitrate for angina? I believe IM is a Nitric Oxide donor and was wondering if the combination of NMN and IM might be the reason why my results are quicker and more noticeable than any reports I've seen?

[@orion9k]

I think nmn will reverse hair color by itself

[@catman4471]

@@orion9k Quite possibly but I did find that its the Statins that are causing my hair to turn yellow in places. Most of my body hair is back to it's original colour, but it seems that the same areas of head hair that turn yellow with statins go on to show the most darkening.

[@orion9k]

@@catman4471 interesting😊 I just ordered nmn, b3 Nicotinic acid (niacin) and b6 few days ago, I'm having it delivered tomorrow, first time ever trying it out.. if it's half as good as people say, I will be so grateful because I've had chronic fatigue since 2020 and even tho I still get my gym workout done, I'm tired 24/4 and can't lift as much as I could before my stress burn out 🙏

[@catman4471]

@@orion9k I wish you the best with it. Many people report it having an effect within days, others take longer, but here's a few tips for you: When and as you can, try a few other supplements too...TMG should be taken in equal doses with NMN. Resveratrol and/or extra virgin Olive oil to help activate sirtuins. Berberine, around 900mg per day spread out in 2 or 3 doses will really help with your workouts and stress. Be careful where you buy from though. I'm in the UK so I purchase from donotage for fast and fresh delivery but check your country for best suppliers or take the advice given by many here on YT.

[@sahararshad5044]

@@catman4471 can you please explain what exactly it do? I have muscles weakness from many years can i give it a try?

[@biologySoon]

Can NMN lead to higher cancer rates in humans due to the timing and activation of NMN? What about methylation?

[@andrewrivera4029]

Or you could intermittent fast, block fast and reduce carbs which costs nothing in fact you save by not eating periodically.

[@DmitryShevkoplyas]

Thank you, David!!!

[@jameslewis1605]

Who wants to live forever?

[@Adammk1974]

me

[@gf4353]

It would give me a chance to finish my. To do list

[@Timvandervliet]

Very good info. Love it. Thank you.

[@catman4471]

Update on my previous comment: It's not the isosrbide mononitrate causing the effects mentioned below, it's Atorvastatin. I noticed my best results from NMN was when taking around 100mg per day from a good supplier, but these effects decreased at hgher doses. Due to running out of Atorvastatin, I was off them for a week to find 1g doses of NMN kicked in again, but decreased effects once I started the statin again. Also, taking statins and NMN at 1g causes statin side effects. I need statins to decrease cholestorol, have had a stroke and have heart disease, but it seems that I need less NMN when taking Atorvastatin. Do you have any information on interactions between the two?

[@orion9k]

I've just received my batch of nmn, taken 200 mg for two days now but I'm very sceptical because it taste strongly of lemon with a slight taste of amphetamine.. I mean, if they are adding amphetamine to this, no wonder people feel energized when they take large doses ..

[@catman4471]

@@orion9k NMN does taste slightly lemony. If you've purchased from a reliable supplier you've got nothing to worry about. Also, you should experiment with doseage as guidelines vary from around 250mg to 1g per day. Your current age and health contribute to the amounts you might need. If you're over 50 you're nad levels are possibly 50% lower than when you were younger, but again that also depends on your current state of health, diet and exercise routine.

[@orion9k]

@@catman4471 Thanks for your reply. So I got my NMN along with B3 Niacin (Nicotinic Acid, the one with flush which I actually find pretty awesome) and also B6. The B6 made me feel completely weird so I stopped that after taking 25 mg morning and 25 again afternoon, I felt really on the verge/borderline of psychosis... The B3 nicotinic acid really gives a positive effect, I feel warm and slightly more energetic when I take it. The NMN still hasn't done much for me, I took 300 mg today, but I will keep increasing dose. I just bought Creatine today as well, heard a lot positive stuff about that too. I'm 37, I weight lift 2 hours 3 times per week, I try not to overeat with carbs and proteins even thou many promotes this when weight lifting, I think I'm around 1800 calories per day and around 80-90 grams of proteins, I'm 182 tall and 70 kilo. I also eat a lot of oils like MCT, Olive and Fish oil, I'm getting like +1 gram of DHA and also taking magnesium, zinc, MSM, Spirulina tablets, 5000 units of d vitamins with k2 added and between 6000 and 8000 mg vitamin C per day (2000 mg in the morning and per meals/smoothies) which actually has helped to make my sun allergy and long recovery time from weight lifting go away, but I have no idea what levels my NAD is, I just know that I'm trying to get my energy levels up, I'm tired all the time and my brain is foggy a lot through out the day, I've become very stress sensitive since 2019, so I'm trying everything I can to get my shit together.

[@catman4471]

@@orion9k Hi, NAD levels start decreasing around age 35 so you won't really notice much of a difference especially as you're getting ample exercise. You might like to look into taking Berberine though, around 900mg in 2 or 3 doses spread throughout the day, but not on days that you exercise. It helps with energy and muscle definition amongst other things such as stress and brain fog.. I like flush Niacin and often take between 500mg to 1 gram depending on if I've run out of NMN or not, and I take it in the evenings as it helps me sleep once the flush has gone. If you have health issues then you might like to think about gradually increasing the NMN until you find a level that suits you, but if otherwise healthy you should stick to a lower dose just as a top up for now seeing as you have already purchased some, but you could save the expense for another few years. Vitamin D Complex is excellent too, so you should be doing alright with your stack.

[@dolores397]

All my best to your health! Keep it up

[@squamish4244]

NAD+ is the first step on what will be a busy road of rejuvenation therapies in the next 50 years or so.

[@jason5265]

So you’re making pharmaceuticals

[@KekeeBlack]

Jason Lynch he’s going that route because supplement companies scam people a lot. I kind of wish he wouldn’t but whatever.

[@JaysonT1]

@@KekeeBlack Like Pharmaceuticals don't scam people?

[@bushieth537]

What about the link between NMN and damaging impact on athristus?

[@darlingdear2687]

Yeah, but angiogenesis is responsible for cancer growth. There is a fine line you have to walk here

[@darlingdear2687]

@@jdoggraw1010 no it's not. "The formation of new blood vessels is called angiogenesis. It is a normal part of growth and healing. But it plays a role in several diseases, including cancer. A tumor needs nutrients and oxygen to grow and spread." www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/angiogenesis-and-angiogenesis-inhibitors-treat-cancer

[@darlingdear2687]

@603spikem I never said it creates cancer, I said "is responsible for cancer growth". It facilitates growth of the tumor - it's not enough to have one damaged cancerous cell, it needs to grow to become a tumor: angiogenesis facilitates the growth

[@mikebelk8641]

Is nmn available to the public?

[@byzantinecaptain]

Yeah, Helix Heal on Amazon is the purest

[@chloe7seven22]

I think a ketogenic diet will do all of that. My blood showed it.

[@shelchicago8997]

Harvard made a smart decision to have Dr Sinclair

[@XR650L_GUY]

Wow!! The rich will be even better off than they are now.

[@ufosrus]

Keep it up researchers, you're doing fine!