Reverse Aging: Dr David Sinclair on NMN & Anti Ageing supplements (including their side effects)

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David Sinclair is a professor of genetics at Harvard Medical School and the founder of the Sinclair Lab. He’s the author of the bestselling book Lifespan: Why We Age-and Why We Don’t Have To, as well as a founder of several biotech companies. #bestsellingbook #biotechnology #genetics
Auren and David discuss the potential to expand the average human lifespan by decades. David challenges traditional notions of aging and emphasizes the need to embrace new technologies. They also discuss the benefits and drawbacks of standard anti-aging practices like interval training, fasting, and stress reduction.
David shares his thoughts on what longevity medicines and supplements are most beneficial, and how to talk to your doctor about them. He breaks down which health metrics to monitor in treating and preventing aging. Overall, David offers an incredibly optimistic vision for what the future of aging could look like, and the science it will take to get there.
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You can find Auren Hoffman on Twitter at @auren and David Sinclair on Twitter at @davidasinclair.

[@worldofdaas]

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[@GoruMuta]

How can I get in Nepal any idea please

[@HH-gv8mx]

Doesnt berberine mimic Metaformin?

[@GoruMuta]

@@HH-gv8mx you can't provide nmn subliment in Nepal ok

[@guomeili1090]

😊😊😊

[@mahin6451]

Aza aZ😊😊àa😊😊😊a😊aàacc c

[@ronedee]

in a word.... FASTING! I've been intermittent & long-term fasting for 40 years, the last 15 very seriously. I'm 67 and people never guess my age. Recently, someone guessed 52! I smiled and said...older. I didn't want to shock him. That said, a diet w/o sugar and processed foods is mandatory! Also, gut healthy foods are needed for healing & repair. And an active lifestyle. Once your body cleans out the years of toxins, a bad diet will actually get you very ill feeling.

[@Vgallo]

Fasting gave me hypoglycaemia and peripheral neuropathy. Also not everyone tolerates nmn, very little is understood about this

[@ronedee]

@@Vgallo ..well centuries of Fasting has plenty of very positive results. People just like their food and will fight to the death for it! Literally! If you have weak or failing kidney's fasting isn't for you, or anyone else with that condition. Nothing else has ever been deemed hazardous to ones health from it. Except of course starving yourself...which ISN'T Fasting! But negativity towards it even in that face of stunning results isn't hard to understand. I've experienced it firsthand for decades. My results is my proof. Amen

[@camarosspr]

Do you have great muscle mass? Fasting muscle wasting

[@ronedee]

@@camarosspr . better than most people my age. Fasting won't affect muscle or tissue for several weeks without food. Your body will eat all toxins and fat before. Don't know where everyone gets their info. And think they know more than someone who has done fasting for decades?

[@leslielucci3182]

@@camarossprfasting increases growth hormone, great for building muscle. Ideally periods of fasting should be cycled with periods of feasting. See books from Dr Jason Fung.

[@michaelchaplin866]

I started when i was 27. Diet change from anything and everything to 80% vegetables, fruits, and legumes manly. Started fasting around the same time. Day fasts, 2,3,4,5 day fasts, just water. Upto 8 day fasts. Drinking upto 1 litre of water a day. This was incorporated over 5 years. Over last 5 years been working into my lifestyle intermittent fasting. First taking out breakfast, which took about 1 or 2 years. Then lunch. Now at the stage of Monday to Friday i eat in 2 hour window in evening. Breaking fast with homemade yogurt, with L.reuteri (see Super Gut book by William Davis). Been taking Ceremonial Grade Matcha for past 1-2 years most days. Cold baths almost every day in the morning. Now, this year (been on the to incorporate list) starting with NMN, resveratrol, quercetin, vitamin k2, d3, C, Omega 3s, B12, and some others. I've never taken any supplements before this year. Always thought I'd do the free stuff first, like fasting, exercise, cold baths, etc, and then add on the other stuff. Im 37 and last month had my age guessed by 3 people of different ages from 23 years old to 45+ and all said they were sure i was in my late 20s and were quite shocked when i told them my age. That was with my beard longish. When i shave it off, i look 5 years younger still. Ive never, ever consulted a doctor regarding what i do. The reason i started it all was because i was diagnosed with IBS and they put me on some powder stuff which didnt work and went back and they wanted to put me on something else and i said "if you think im going to believe you after you said that powder would work and it didnt, im not going to take those now am i". Left and never looked back, took my health into my own hands, read loads, researched and applied it, cured myself in a month or 2. Not easy to change years and years of habits ingrained into each of us, but if you chip away little by little, you will achieve loads in 5-10 years. My advice: dont try and do it all at once. You will not be able to do it. Accept you dont have enough willpower to take it all on at once. Pick a couple of things you want to address/change and focus on that. If you do this, you won't even notice the change, and 10 years goes by, and like i do, i think "my lifestyle is nothing what it was 10 years ago." Replacing habits takes time, dedication, desire and effort. It is now effortless for me to do 48 hours without anything but a few glasses of water. I can work all day in my manual labour job without eating anything to 6pm sometimes no problem. Now if i eat, let's say a bowl of sugar cereal in the morning, I feel utterly terrible. Its important i found to not be 100% strict. I found that letting myself have what i would have had before once of twice a week is really good because you have that contrast and i re-realise why im making effort to change that.Peace to all. Its never too late to change. 😊

[@subash187]

Well put my friend.

[@joeschnur4632]

Nice comment. I also took my health into my own hands. I’m a year into the journey at 55 yrs. I pull together a group of like minded people. If you’re interested in joining message me.

[@gtracer6629]

I've only been doing fasting for about a year but I have been skipping breakfast for over 30 years not realizing it was called fasting. I find it interesting that so many people back then would scold me for not eating breakfast. When I go two or 3 days fasting I still get a lot of feedback from people. I think the first thing they ask is "aren't you always hungry". With the concept of fasting be coming more😁😁 accepted, those people who questioned me before now look at me as if I'm a trendsetter. With all the information that's out in the world on the benefits of fasting, I now just smile and let them go on thinking and I'm smarter than the rest of the people or ahead of my time. 😊

[@gloriamitchell4005]

I was studying health since the days of Adele Davis and just kept on learning. Bad accident put me on my back. Hispital and rehab kept me from my project found Dr David Sinclair researched NMN and got it; I try not to miss anything he reports or says. What NMN does for one is amazing

[@jeffhaggerty402]

Good to see you say that. I'm from the Adele Davis days as well. So you are seeing good results with NMN? The one thing I had is that within a week someone told me that I looked great. It for sure gave my skins/cells some type of outward boost. I have not noticed much else yet, but I am still early.

[@benkaiser5378]

lookup Peptides.

[@broganjosh4729]

I was on your journey 4 years ago right after Sinclair first did a JRE podcast. However, since then several things came out that made me question Sinclair's credibility. Even so much so that if it were to be discovered that he uses botox and does some snake oil salesmanship, I wouldn't be too surprised.

[@egar5027]

I think he uses botox too... that forehead is totally unnatural and frozen... but i'm still listening to him though 🤭@@broganjosh4729

[@HH-gv8mx]

What does NMN do for you and which product do you use? I take NAD but I may be wasting hundreds of dollars. Dr. Drew swears by it. 🤷‍♀

[@HussaniAliyu-tm6qy]

Living in remote part of Africa and I benefit from your podcast on healthy lifespan. Thanks for all your efforts

[@worldofdaas]

Thanks for watching!! If you are interested in the health and longevity space check out this interview on How to Track Health better kzbin.info/www/bejne/mKOTe6SEip2InNUsi=DMfHvey9zvn_44JS

[@user-eq3jg4dq9d]

8:30 10:40 13:50 Sinclair's diet talking about longevity and and fasting went from total fringe(border or outer edges of an area or a group) in science to now mainstream

[@moniq2478]

Dr Sinclair often mentions he has some sleeping problems. Taking NMN I've noticed that his dose was definitely too high for me and I too experienced some sleeping problems, literally it shortened my sleep from 8 to 6 hours. I reduced the dose and my sleep improved right away. So my conclusion is - although studies show that NMN is good for us (or other supplements), we should adjust dosing to our own needs, because after all we are different (body type, body sensitivity, nutrients absorption re stomach acid etc).

[@Angry.Hippie]

Were you taking it in the morning or the evening? I do try to take mine in the morning for that reason. If I take it too late in the day it keeps me amped.

[@moniq2478]

@@Angry.Hippie in the morning. Reading some results of clinical trials for NAD+ precursors it’s quite clear that the dosage triggers different outcomes. I understand that his daily dosage is an optimal dosage, but studies suggest mg/kg.

[@arielmalanga]

@@moniq2478 I take a relatively low dose of NMN. A high dose makes me feel strung-out and definitely impacts my sleep.

[@HH-gv8mx]

I take NAD in the evening when I get home from work so I can do a workout. I’m often too tired to workout after work. The NAD is supposed to give you energy. I never really feel a burst of energy but I do notice, but once I do start working out, I can work out longer. And be more focused. And then I have trouble sleeping. I may get a few hours of sleep but it’s not quality.

[@HH-gv8mx]

My sister recommended that I take inositol to help sleep and ashwaganda. I wonder if taking all these supplements have any deleterious effects on the liver or kidneys.

[@LucasOConnor4fun]

Some constructive criticism for the interviewer....try not to interrupt. Keep up the good work

[@JackB2646]

The only side effect so far for me (just started taking it) is I must take it first thing in the morning or I don’t sleep

[@smartturkey123]

Look up Sinclair's role in the FDA banning NMN from being sold without a prescription.

[@MsHenryoh]

Dr. David Sinclair is a great speaker but not sincere he does "own" different companies that sell his supplement recommendations. Do your homework in research. I have seen him here for two decades and tried his expensive supplements. Longevity is gained by eating good food and exercising! It has propelled me into my later years watching friends and family go by the wayside. He actually looks a decade or more older he himself is growing old! We all grow old it is a fact of life. Stay healthy!

[@antoniobortoni]

It's indeed true that as we age, our skin loses its elasticity and may not return to its original form. However, it's essential to note that the aging process encompasses more than just skin appearance. The true indicators of health are metabolic and biological age, which might not always align with our external appearance. It's not just about how we look, but about the overall health and vitality that we maintain internally.

[@eventhisidistaken]

We're all growing older because we haven't figure out how not to. But his 'looks like' age is about 40, and he's 54.

[@lonneestar1583]

so whats his company's. He always states the basic supplement Ive never heard him say a specific company. Please tell us all the companies.

[@wrfootball3847]

Agree, if I look at him he still looks minimum 45. Yes he is 54, but you can see he isn't very young. He is healthy yes but it's not like he looks 32 or something, he doesn't! As you say we all get old, he could look much worse I Agree, but overall he doesn't look very young either

[@bq3538]

older != Religious creed

[@wandalast6618]

I love this Dr Sinclair . He is so intelligent and nice

[@worldofdaas]

Agree! Please share this video with anyone you think might also enjoy it :)

[@o1all960]

He’s a fraud

[@AL_THOMAS_777]

LOL - you haven´t seen ME yet . . .

[@lenmil8421]

Did you bank with Sam bankman fried as well.

[@anthonymason385]

I'm disappointed with David's company getting nmn banned. This is a direct copy of what he did with the grape skin supplement years ago. Still I love the guy. Looks like a good bet to crack this ageing problem once and for all. Fingers crossed.

[@soylentmajority989]

I'm just happy that he's seemingly been thwarted about NMN. Something in the system is working better than I thought it could.

[@SandyCheeks63564]

why & how did he get it banned?? or is it now by prescription only?

[@broganjosh4729]

That and some other things made me question Sinclair's credibility. Even so much so that if it were to be discovered that he uses Botox and does some snake oil salesmanship, I wouldn't be too surprised.

[@catman4471]

It's banned in the US but the FDA has not enforced the ban and may decide not to. It is still available in the US through online retailers, and the ban is awaiting review. The arguement is over who registered their interests first, the pharmaceutical or supplements industry. The FDA has admitted not 'connecting all the dots' when they banned it as a supplement.

[@jasonwestwood7092]

You can't stop ageing slow it down in some cases but not stop it.

[@thomasmartin2000]

It would be intersting to learn about the long-term NMN supplement effect with regards to exacerbate inflammatory arthritis

[@gianlucazanon1505]

I was about to suggest NMN to my mother. She suffers from arthritis and luckily I read your comment and started reading about a study on that. Thanks

[@lgroves336]

NMN TMG changed my health / life

[@esraaltin6542]

For Bad or for good??

[@bfogarty949]

David does looks younger than several years ago. Something is working for him.

[@wigglywrigglydoo]

Money

[@Fearzero]

Surgery, fillers, botox, dyes, hair transplants.

[@Fearzero]

@@Jay-eo3wl Hard to tell if he used a great surgeon. Don't have to end up looking like Mickey Rourke.

[@venice2823]

Lol you can tell he hasn't had any of those things. @@Fearzero

[@Fearzero]

@@venice2823 I don't think you can.

[@UNKLELUKE86]

Taurine, Glycine, and NAC. I try to walk after every meal.

[@fantasticallyfit6030]

Most everyone knows you don’t sell NMN. However you want to turn it into a drug. The company, correct me if I’m wrong, is Biotech which you are directly associated with. 🤔

[@roblangsworld]

Thats why its banned in the USA,so it can be tweeked and marketted as a drug of which that company owns the patent! Fortunately NMN is a naturally occuring substance so "presently" they wont be able to tie it up! Big Pharma at its evil best once again!

[@soez_strg6166]

I find it sad how everyone hyperfocuses on NMN because it's expensive and someone shills it. In some people Niacin seems to work better lol. NMN is overpriced as hell, sold by evil greedy people who sell it for like 1000x for what they pay for it from their chinese vendors. And then don't even test it, meaning you can't be sure it's NMN.

[@cherubimcherubim9515]

20 years later no closer to any cure for ageing. In 2003, his lab was small and struggling for funding.[3] In 2004, Sinclair met with the philanthropist Paul F. Glenn who donated $5 million to Harvard to establish the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard.

[@addictedtochocolateandcoff9582]

how many supplements do you take

[@cherubimcherubim9515]

Only omega 3 nothing else

[@catman4471]

That's not really true, there have been some amazing discoveries in the world of Longevity.

[@cherubimcherubim9515]

@@catman4471 like what exercises, eat well ?

[@catman4471]

@@cherubimcherubim9515 Any exercise increases NAD levels, so he more you do the better it is for you. There's some debate over the benefits of intermittent fasting, i.e. leaving at least 12 hours between meals, but it works for me. Also, eating healthy foods is always preferable to junk food, those high in sugars etc.

[@KJSvitko]

You are your own best health advocate. Eat a healthy whole food plant based diet, reduce stress, get adequate sleep and exercise regularly. Every adult and child should own a bicycle and ride it regularly. You will be healthier, happier and have lower transportation and health care expenses. Make a bicycle your first choice for short distance travel. Exercise and stay active.

[@jkherold63]

I agree with everything you said except total plant based diet. I eat organic, free range chicken and wild caught fish. I work out hard - lots of cardio and light resistance training. I'm 60 and most people guess I'm 40. It's hard work, but i want to live a long, healthy life.

[@catman4471]

You're right of course, but there's a difference between health supplements and longevity supplements/reverse ageing supplements.

[@MNTrader2012]

You still won't go beyond the normal life span.

[@KJSvitko]

@@MNTrader2012 Maybe so but you final decade or two may be healthier and more enjoyable and not riddled with medical issues.

[@catman4471]

@@MNTrader2012 In my case and that of many others, living healthier for longer is the primary goal of Longevity, and any extension to lifespan is a secondary bonus.

[@jordanong5114]

Transformers anti aging starts right now! We fight 60! And I would love to be Dr. Sinclair’s assistant and we can get all the help we need.

[@worldofdaas]

The best time to start was 20 years ago, the second best time is right now!

[@abdulazizkechik9200]

They will increase retirement age to 90 soon 😅

[@AL_THOMAS_777]

@@abdulazizkechik9200 DONT let this happen guys !

[@TheBiffsterLife]

“One of my companies is doing clinical trials”….”but I’m not selling the stuff”. - Sneaky Sinclair 2023

[@PolishBehemoth]

A man hiring private research to research things that no government or company is doing... Hmm.... So how else is he supposed to research this stuff without creating his own company?

[@TheBiffsterLife]

@@PolishBehemoth It’s like if Elon Musk was to say he doesn’t sell Teslas because he doesn’t work in their dealerships. In Sinclair case it’s weaselly because he has commercial ties to that work.

[@eventhisidistaken]

He is a Harvard aging researcher. That's literally one of the things he does for a living - clinical trials.

[@TheBiffsterLife]

@@eventhisidistaken You don’t see the contradiction in what he said?

[@Cenot4ph]

Sinclair is a snake, he will promote things out of financial interest not because it's the truth. Verify everything he says

[@morskoyful]

There is a main cell in the body, it has a thought, this is the soul, all information is stored in it, and it is immortal. The decision is made by the thought of the main cell

[@mitubogoogle]

I hope Dr Sinclair has read the research papers (since the talk with his doctor) that high cholesterol DOES NOT CAUSE HEART DISEASE. Only an oxidative form of LDL can cause heart disease OR very high triglycerides along very high cholesterol and glucose are reasons to take statins.

[@SquatFull]

Dr. Sinclair is a storyteller passing information as scientific facts.

[@terrimac996]

Substitution of plant protein for animal protein decreases the established lipid targets low‐density lipoprotein cholesterol, non-high‐density lipoprotein cholesterol, and apolipoprotein B. Or in even simpler terms less oxidative stress or oxidation.

[@pjaworek6793]

"A person is considered at high risk for developing heart disease if their total cholesterol level is higher than 240 mg/dL, LDL levels are higher than 160 mg/dL (190 mg/dL is even higher risk), and if the HDL level is below 40 mg/dL"

[@disinformationworld9378]

There is never a good reason to take statins. Fix the bloody diet.

[@willcook403]

@@SquatFullwhy do you think that ?? He’s got all the credentials and experience which shows his skills aren’t that way.. Expand on your thoughts though.

[@manuelojeda9144]

I stopped taking Metformin, because it causes muscle waste plus bad stomach issues. I was taking BERBERINE for a few months I STOPPED FOR A WHILE 8:30 . I do take NMN with extra virgin Olive oil, and TMG, also NR, CalAKG from ProHealth Longevity here in California. USA. IM a strong senior.

[@mprado4177]

Why take NMN and NR? They are supposed to do the exact same thing.

[@manuelojeda9144]

I thought they were two different supplements.

[@mprado4177]

@@manuelojeda9144 They are two different supplements that do the same thing, they are NAD+ boosters. If you are taking both, it’s like taking twice the amount of one. May be too much.

[@wulfsorenson8859]

@@manuelojeda9144I’ve been on metform too. Does it causes stomach bloating? I noticed my stomach is looking extremely bloated after meals.

[@ELEVENNE1978]

Ca akg is great. The clinical trials had great results

[@erinmorano4425]

NMN has been LIFE CHANGING for me. I actually started out with NR which is a precursor to NMN. It started when my geriatric dog, started getting very sick. He had been sick for a long time and its just been getting worse. He didnt want to be touched and only wanted to lay in bed and sleep all of the time. Well, my sister had a cat with kidney failure that was given 6 months to live. She gave the cat nmn and it began to recover and started eating again. After a while, the cat was normal again. It did end up dying but because of the nmn, it lived an additional 22 months! So, back to my 14 year old, elderly dog. Id spent thousands of dollars at the vet amd he was not getting any better. I was sure he was going to die so I started him on NMN. He was in really bad shape and it took him 3 months before I saw any improvement. But one day, I notced that he started felling better and as time went on, he got better and better and better. He is so healthy no that he no longer lays in bed all day. Not only that but he plays with toys again. Id not seen him play in years! And even better, he does it every day! 2 years later, he is still alive. Hes a happy little dog now that barks at strangers and walks around the house all day doing dog stuff instead of only sleeping all of the time. After I saw how good he was doing, I thought, " Damn, I want that for me too!" About myself. Im 44 but suffer from grevious mental illnesses. I was almost alway miserable all most all of the time and contemplating suicide. So after seeing what it did to my dog, I started taking it. It only took me 2 weeks to respond to it but when I did, wow! Oneday, I noticed I was feeling a little better, and the next day I was even better and the next day the same. This went on for a month and by the end of a month, I was on top of the world, I had not felt this good in damn YEARS! My mental health problems are not gone but they are very light now, so far as to say, Im not suffering at all anymore. But it should be noted that after discovering how nmn workd for me, I embarked on a journey to find other suppliments that might help, and I did! Im not even close to the same person anymore. I love life now. Due to my metal illness, my memory was crap and I was constantly forgetting stuff. Well tha5s got now but now its even better. I remember everything! Ive never had a memory this good. My wife is on the stuff also, as well as my 72 year old elderly mother and we are all expirencing similar results bit it definitely helped me the most because I was so bad off.

[@Tennyhu]

How much nmn did you give your cat?

[@ZeusHelios]

What other stuff did you take?

[@antonystringfellow5152]

Thanks for sharing your experiences. I've seen David admit that there's little to no difference in the results of studies between NR and NMN (both NAD precursors). Hardly surprising as NMN is converted into NR before it can be converted into NAD. So, you may ask, "Why not just take NR?" The main benefits of NMN over NR are: 1. NMN is more stable. NR can start to break down into NAM if not stored correctly (cool and dry) and you do not want extra NAM. 2. NMN doesn't have the foul taste of NR. There's very little difference in cost too so you might as well buy the NMN.

[@erinmorano4425]

@@Tennyhu 500mg

[@george6252]

Look into GlyNAC

[@manuelojeda9144]

I've been taking NMN and NR plus AKG and TMG powder.

[@worldofdaas]

Have you seen any results? Also if you are interested in health tracking --> kzbin.info/www/bejne/mKOTe6SEip2InNUsi=DMfHvey9zvn_44JS

[@robynhope219]

U must be rich😮

[@camarosspr]

Of course maintaining and building muscle mass takes weight lifting. It's hard. Absolutely required after 50s. The good proven one is bodybuilding Anything else is... Cardio, cycling, running incurs muscle wasting. Cardio is not effective for weight/fat loss. Only diet is effective. Plus the injuries, broken ankle bones.

[@wulfsorenson8859]

What about rowing as a form of cardio? It builds lean muscle

[@felicisimomalinao1981]

Is NMN worth the cost? Some people do not benefit from NMN or resveratrol. I prefer Niacin - a cheap precursor.

[@Fearzero]

No studies on nmn show that it makes it into muscles. It's snake oil.

[@garretsc]

Exactly, niacinamide to be precised (NAM), gves better results in NAD+ boosting than NMN and it is cheap.

[@soez_strg6166]

Even normal Niacin gives better results. NMN only makes sense with certain gene mutations.@@garretsc

[@bq3538]

@@garretsc NAM is harmful to Sirtuins

[@blissfitfoods]

Not really NAM has side effects.

[@morskoyful]

We don’t think with our brains, each cell of us is autonomous, just as in a factory the director thinks about the plant, and the cleaning lady thinks about the mop. When a person's head is changed, you will be convinced that it is not the body that has been changed - the head, the main cell is in the solar plexus area.

[@timofeishe]

How could I accept any information about longevity coming from people who use skin filters to hide their aging?

[@popothebright]

Or from people who lied about their previous resveratrol research and sold it for millions.

[@maarten7]

Exactly. He's a fraud.

[@soez_strg6166]

how can you tell? just curious

[@timofeishe]

@@soez_strg6166 I'm a photography in videographer. After a little practice, it's very easy to see.

[@leoszilard3998]

How much did they pay you to mention metformin,Your kidding,The side effects of that alone makes me believe your being paid for that.A friend started taking metformin and he said he felt sick to his stomach and stopped taking it and then felt better.

[@robynhope219]

True, been taking it for two yrs and have to tolerate side effects. But Met has so many health benefits I don't want to quit. It's is anti aging!

[@Josh-Jones]

Title is wrong, says "MNM" and should say "NMN"

[@Ppomia]

NMN is correct

[@chesstictacs3107]

Corrected now

[@emdude1784]

Some are commenting negatively about his mostly Vegetarian diet. Personally I am NOT a vegetarian, I love my meat, and realize that meat protein and fat are critically important to people like me who follow a low carb/keto diet. But I also pay attention to all blue zoners. The Loma Linda seventh day Adventist are vegetarians and they are blue zoners. They do not eat meat. Thoughts?

[@jerrybelioso1209]

A study is just that....an observation of a select group of people!! A study can almost never provide an answer for the whole of the human race!! We fail to see that nature is too complex to be defined by whatever number of studies and therefore too often, contradicting data emerges about the same chemical or molecule!! And...likewise to humanity as a whole, one individual human (body) has too many aspects to it to suit one definition , brougjt up by whatever number of studies!! Yet, we mustn't look away either from consensus data. We are simply not there yet!! Evolution goes on forcing us to look further still to that which heals us and that which harms us

[@middleearthltd]

The longest lived Blue Zone population is the Loma Linda Adventists. So they are the best of the best in a sea of unhealthy Americans. As a general matter, high complex carbs with zero to very little meat, and adding fruits and vegetables is the most efficacious path to functional longevity. The Adventists are not hitting the gym but they are hitting an active life. Pretty simple formula for a long and happy life.

[@emdude1784]

@@middleearthltd interestingly Adventist outside of Loma Linda who are vegetarians are not as healthy as the LL population. I happen to know the Adventist community pretty well and my evidence about the Adventist outside of Loma Linda is generally anecdotal. I have often wondered if there is a genetic component to the LL Adventist who tend to marry within their Close knit communities

[@Fearzero]

I just look at the science Randomized controlled and large observational studies are great for ferreting out facts around meat vs plant protein. May 19, 2020 Cochrane Library, 59000 people, randomized control trials meta analysis; The review found that cutting down on saturated fat led to a 21% reduction in the risk of cardiovascular disease (including heart disease and strokes). The review found that health benefits arose from replacing saturated fats with polyunsaturated fat or starchy foods.

[@maarten7]

He left his wife and kids for the vegan freak Serena Poon.

[@romescala_aban3125]

Pls its a must read dr brad stanfields review on sinclair claims its an eye opener...

[@mitubogoogle]

Some functional doctors are recommending to take NAD supplements - wonder why Dr Sinclair recommends MNM instead?

[@Bigmdn29]

Because Nad is a big molecule not easy to absorb and Mnm is smaller I can turn into NAD better absorbed in the cell .

[@pjaworek6793]

Nmn is the nad supplement for oral ingestion. Straight nad can be used for injections.

[@soez_strg6166]

Doctors simply follow his adivce and bastardize it. @@Bigmdn29

[@oksanach.4358]

I feel like Dr. David is already bored talking about NMN...😂😂hearing each time same question: so what is actually mnm? Explain us😂😂😂

[@luckspell]

Someone do an interview of Dr Sinclair's age reversal molecule that Harvard medical just discovered.

[@ZeusHelios]

What was it?

[@orion9k]

What molecule?

[@luckspell]

@@orion9k Just search

[@ELEVENNE1978]

Some 1 already did. He's not releasing what it is until patented obviously. Still gonna take another 10 years to perfect it though

[@oleeb]

Easy for Dr. Sinclair to say "take NMN" when he gets pure NMN from his lab. The rest of us have to settle for retail supplements hoping they actually have NMN in the amounts advertised.

[@MichaelMerritt]

I have Hashimotos and NMN increases body inflammation and flares me, tried a few brands. So not all is good with everyone. It seems to modulate my immune system enough to upset it.

[@fantasticallyfit6030]

Maybe you had a bad source. I have Hashimotos and have been using NMN and I have had no negative side effects

[@MichaelMerritt]

@@fantasticallyfit6030 I tried alivebyscience three different forumulations (they’ve rebranded their company a number of times now), doublewood and do not age. It also only happens with dosages above 600mg. Everyone is different, for me it definitely inflames me and messes me up. If you read about Th1 and th2 dominance it’s not uncommon hashi people are one or the other and in general it’s a bad practice to be modulating your immune system when you have auto immunity, esp in the direction your body is already leaning. I really wish I could safely take it, seems like a great supplement.

[@leslielucci3182]

Dr. Sinclair takes NMN with several supplements, resveratrol, tmg and metformin (prescription)

[@lion-kz2ks]

Which brand do you use..?

[@yokos5714]

I tried Do no age NMN with TMG from life extension and it gave me a major rosacea flare up. I tried a few more times, same bad reaction😫

[@b.bondwilliams6847]

Did Sinclair want all NMN banned by the FDA, except the NMN made by his own company?

[@kamasutraninjagrus]

Meh… still haven’t seen any decent studies

[@Fearzero]

Yep. Charlatan.

[@JackB2646]

Highly unlikely

[@orion9k]

​@@kamasutraninjagrus​​ i tried two different nmn brands, perhaps placebo effect in the begining but after few days did nothing. I gave it another chance half year later, but still no effect. Niacin b3 nicotinic acid does way more, you see the red skin flush and the blood flow increasing, i believe this is way more effective on NAD and 10x cheaper.

[@malkeir9781]

It was a certain type of nmn that his company either engineered or found.

[@timetravellist1930]

If NMN is beneficial in humans, why is David Sinclair spending a fair amount of money paying lawyers to stopping that getting to the general public? This is why I love Bryan Johnson.

[@maryroberts6311]

his backers, not him

[@maarten7]

He's a huckster. Oh, and not a great reputation at Harvard either.

[@lia6912]

That's actually a good thing@@maarten7

[@orion9k]

NMN does nothing for me. Niacin b3 nicotinic acid on the other hand does way more and 10x cheaper.

[@timetravellist1930]

@@orion9k NMN did nothing for me too. Tried it for 6 months. I've looked it up and it'll only work on 65 years and up.

[@wSpaceArt]

CDXC is selling NR. Last year Aug analyst's prediction of the stock price was ~USD5 and this month one prediction is the same. Actual is ~1.5. Harvard and other scientists are selling and betting pn this, including Cure's Alzheimer's disease fund.

[@maarten7]

What hair-dye and colour does Mr. Sinclair use?

[@trogpo]

He emphatically claims he doesn't. I'm not positive he does. His hair doesn't have the topical cast and sheen of colored hair -- as opposed to Bryan Johnson's hair, for example, who certainly does.

[@maarten7]

@@trogpo It is obviously unnatural. This is not difficult to tell.

[@trogpo]

@@maarten7 To my eyes it is not obvious, although it is very likely, as he most certainly done heavy botox treatments. So he certainly have no scruples to present himself in a deceiving manner.

[@maarten7]

@@trogpoI believe him to be a charlatan. He doesn't have a sterling reputation in the Harvard community.

[@trogpo]

@@maarten7 Thanks, interesting. The undisputable fact that he uses Botox without declaring it, as he should, is very disappointing to me. I'm 55 and follow his advice thoroughly for some years now, and with great result in physical and athletic ability, as can be seen in the demonstration. No Botox, nor hair dye -- have some gray hair on my sides. Of course I'm not deluding myself that I reversed my age -- e.g., I think I have a bit more gray hair now than I had four years ago, certainly not less -- but truly believe that I'm somewhat slowing down aging. Of course, that's subjective. I wonder if Sinclair's blindness reversal experiments are legit, because if indeed he reversed a nerve damage, than it would be difficult for me to call him a charlatan.

[@purplehill1270]

Interestingly enough, There have been several studies showing that NMN does not have any effect on the body, positive or negative, furthermore, it seems to be absorded and broken down too quickly and has never shown to increase NAD in muscles. I urge people to actually do their own research or listen to opponents of Sinclair to get the full picture. I understand, however, that getting information from videos like this is far easier. Note: there are other anti aging drugs that have shown great promise.

[@Useryofcsdnx]

Liposomal delivery^^

[@dazone705]

Correct, it's a big difference between having NAD in your bloodstream and and your Cells

[@purplehill1270]

If you have found evidence of someone achieving that then please share the study. Sinclair appears to be the only one getting these lab results. Great claims require great evidence, no other study can confirm Sinclair's results. One should mention he also is selling NMN and attempting to control the supply by lobbying to the FDA to get other companies to stop selling it as a dietary. There are other more promising anti aging drugs, please do not follow this man blindly.

[@soez_strg6166]

Niacin is just as good as NMN.

[@faustopacheco120]

It dramatically spikes your insulin according to one study, which obv isn't good.

[@robynhope219]

Can anyone recommend a cheaper supplement that mimicks NMN? Too expensive for a lot of us...thnx.

[@royceturia1562]

The Seventh-day Adventist Church has been recommending this similar advice e.g. fasting (along with prayer), hot & cold therapy, plant based diet, rest, water, rest etc for more than a hundred years. Look up Loma Linda Blue Zone too.

[@KimLong-v4i]

Please do a show on how important, or not, eating organic foods is. I don't see any shows about this, but feel it has to be super important to NOT put" bug spray" on our foods! 14:12

[@worldofdaas]

This is a great question! I'd love to see some long term studies on this, although the answer seems obvious

[@charlessavoie2367]

John Brzenk is "old" for a competing arm wrestler, he says he takes NAD and he still wins, why take NMN instead of NAD? Add in jiaogulan and carnosine.

[@dynamicalan]

Hello, Where do we get the NMN? Everyone on the internet says there's is more pure.

[@blissfitfoods]

❤

[@robynhope219]

A reputable health store.

[@baileystruss7319]

NMN dramatically raised triglycerides in one small study. What's up with that?

[@slimturnpike]

This is why NR is better

[@ELEVENNE1978]

That might also explain why I got a small benign tumor in my liver while taking nmn for almost a year

[@BalugaWhale]

@@ELEVENNE1978no it doesn’t explain your tumor ..cmon

[@MarilynCaperton]

Where is the best place to buy NMN

[@brightfuture4234]

I'm looking for it MNM but NAD comes up. Is it the same supplement? Where do I find MNM?

[@soez_strg6166]

No, NMN is a building block for NAD, basically your body absorbs NMN and turns it to NAD. You can use Niacin for the same effect.

[@morrobayfishing5515]

The problem with having to go to a doctor is it's 100 times more expensive than over the counter.

[@soez_strg6166]

Also a 1000 times more stressful. :/

[@Gionei1000]

Little or no mention is made of the use of micronized metformin in transdermal cream, which I myself have used for many years. An important detail: the dose should be 10% of the oral dose.

[@btbowden1234]

where do you get it?

[@soez_strg6166]

How do you get micronized metformin? You working in research, bro? Hook us up! Been reading those studies on Metformin in topical application and they seem far more interesting than oral intake due to fertility.

[@MichaelMerritt]

What supplement or med did you slip and mention at 4:50? Before correcting to resveratrol?

[@cmihalcea]

Metformin

[@scubamarilu]

I started fasting, no more breakfast, 16:8 and I sleep way better.

[@akirby2886]

Should Nmn capsules 💊 be kept in the fridge??

[@maarten7]

I keep mine in the refrigerator.

[@blissfitfoods]

No harm to store in the fridge. It should be stored airtight, in dark, cool place

[@dannyp1439]

Sinclair is a big part of the reason nmn was banned. He’s all about himself having access but removing yours. Just wants to make a bunch of money off of it. Disgraceful.

[@artspark7697]

That's not true a drug company went to the FDA and said that they were researching it before him so it was sort of a patent thing and the FDA sided with the drug company but I think it's back on the market.

[@thierryvidal63]

And guess who is on the board of the said company ?@@artspark7697

[@dannyp1439]

@@artspark7697 wasn’t the company called metro international biotech that was cofounder by Sinclair? This is what I’d read and that would make it his fault. If I’m wrong feel free to set the record straight and I’ll delete or edit my original post.

[@nanohatakamachi1066]

It never was really banned dude... Don't fall for some internet rumors.🤦

[@jerrybelioso1209]

True ...i don't understand all this talk of it being banned by the fda? Same with resveratrol btw....i live in the Netherlands, europe and if I want to i can order loads of the stuff from Iherb!! Which is a company in us🤷🏽🤷🏽i bet if i open the iherb app right now i can purchase nmn, nr and resveratrol....it is true though that i can't order dhea anymore from Iherb due to restrictions in Holland so maybe Iherb does the same with nmn and resveratrol for american customers??

[@marcusiA-immortalistMarcus]

nad plus is fantastic. i feel me vrey young again

[@jennifercarter3028]

What brand do you use?

[@HH-gv8mx]

Doesnt berberine mimic Metaformin?

[@deborahjones8329]

I tried to find this pre internet . My father had Parkinson’s. I was there , just couldn’t find what I needed !

[@worldofdaas]

Sorry to hear this and thanks for your comment. If you are interested in the evolution of healthcare you should watch this week's interview with Neil Buddy Shah kzbin.info/www/bejne/h6SqZ4Kbhamkgacsi=aqhvnbk0fxaZb9Au we go deep on AI in healthcare

[@Ajhc73]

What brand is the safest and most effective of NMN

[@FightCollective]

I use Do Not Age. It's one of the best known and respected company amongst the longevity community. Their NMN is genuine.

[@MademoisellleK]

I use Nuchido to increase my NAD level

[@soez_strg6166]

None of them are really that safe unless they provide regular tests, since they probably supply their NMN from china anyway.

[@vapeking466]

Unfortunately nmn was banned by the FDA since it's not been researched as a possible drug. What's the best alternative?

[@dguisinger]

Incorrect, it was banned because Sinclair's company filed a drug application for NMN and the FDA gave his company exclusivity as a drug and banned it as a supplement.

[@ELEVENNE1978]

Best alternative is niacin

[@MNTrader2012]

@@ELEVENNE1978 Indeed. Effective. Dirt cheap. Can't be banned.

[@eventhisidistaken]

I keep seeing videos that the FDA banned NMN, but I have no problem finding it for sale....?

[@frederickcarpenter2879]

Before there was NMN there was NR.. We can always go back to taking NR .

[@АмерикаИзнутри]

Is sirolimus from India safe to take?

[@Arfa088]

Critical Findings From 12 Key NMN “Anti-Aging” Studies Dr Brad Stanfield

[@Fearzero]

He just looked at 1 metric. Muscle absorption. Far from significant findings by him. He hates Sinclair so he's also biased.

[@Nashadelicable]

I was listening to this video and I kept wondering why didn’t I know Robert Downy Jr have a podcast? Like close your eyes and listen to when the host speaks

[@worldofdaas]

This is the highest compliment! And Robert Downy Jr should 100% have a podcast

[@jennifermccullough775]

Can NAC rand Spemaline help raise NAD Levls like NMN?

[@willcook403]

Spermadine*

[@ELEVENNE1978]

No. Nac turns in glutathione within the body and spermidine induces autophagy

[@TheblondJane25]

to all of you who don't believe that people can look much younger as their age is, wake up! Why? Because that is a FACT. My parents look younger, like 20 years younger , my grandparents looked , I do look too and a lot. it is about your LIFESTYLE !!!!!! You eat crap, you will look crap. End of story.

[@worldofdaas]

Lifestyle is very important. If you are interested in how to track glucose spikes and metabolic health I'd love to know what you think of this clip kzbin.info/www/bejne/mKOTe6SEip2InNUsi=DMfHvey9zvn_44JS

[@dalevandenheuvel3927]

How does David get Metformin as it is a prescribed drug?

[@Rawdil]

He said to Joe Rogan that he went to see his doctor, gave him the evidence of its benefits, the doctor agreed and prescribed it for him.

[@camarosspr]

México online drugstores Don't Requiere medical order. Cheaper most.

[@dalevandenheuvel3927]

Have you purchased from them, does it take a considerable amount of time is the product good?@@camarosspr

[@ironmaidenfitness654]

Through prescription

[@maarten7]

It's easy to get a prescription and Metformin is cheap.

[@mixalis6168]

DS is the biggest con in the world today, making millions on NMN which do nothing !!!

[@janetcourtney1512]

I took one dose of metformin- I got so sick from it- horrible gastroenteritis

[@AL_THOMAS_777]

we better not live as guinea pigs until the serious youth pill finally arrives

[@GoruMuta]

My heart volbe is change and I have a sugar can I use it sir please answer me

[@johnely5050]

I am 65 years of age and I take NR as I can't afford NMN.

[@lindacosta3265]

I take 1000mg Metformin because my MD detected a pre-diabetes. Three years later, I am fine, but by now, I notice my muscles are a bit weaker although I take Vits B12, Folic Acid and Thiamine... I don’t think I am not protected…😊

[@camarosspr]

If Theire weaker it's muscle loss. Either age, no exercise, or muscle wasting caused by fasting. Do proven bodybuilding.

[@ironmaidenfitness654]

We can all benefit from weight lifting 🏋🏼‍♀️

[@nukenfry]

Metformin blunts the heath benefits of exercise. Not that you wont receive any benefits, but the benefits are reduced.

[@angeliquevandenberg8877]

Try Berberine instead of Metmorfin. Less side effects

[@antonystringfellow5152]

@@angeliquevandenberg8877 True but berberine also seems less effective. A better alternative might be to take berberine and half-dose the Metformin. Metformin is known to reduce the strength gains from exercise and to reduce VO2 max. Berberine does the opposite. A mix of the two may be the ideal.

[@capgains]

Dr Jack Kruse -Sinclair debate

[@ctguitarguy8510]

Apparently new research is showing NR to be more effective than NMN

[@SookieLuxe444]

Physicist says that going near black holes slows time. If the astronaut was taking resveratrol it might slow it down even more. I wonder about that.

[@Sgv1013]

NMN is not available in the United States anymore so I don’t know what he’s taking now.

[@jha9907]

I just saw it at GNC

[@againsteveryoneswill1923]

You can get it at PureFormulas

[@etseke]

What does NMN mean ?

[@GoruMuta]

How long time it hold in world human body

[@dalevandenheuvel3927]

How can you get metformin?

[@cmihalcea]

Prescription

[@Freckleface2007]

NMN has been taken for decades with no evidence of adverse effects and now a young guy is running a study and advising importance of taking under a doctor’s supervision. My opinion is the studies are great but the motive is money. Sad.

[@TavinhoGodoy]

SO is it better NMN or NAD?

[@TheFoxisintheHouse]

NMN is better ❤

[@m0ose0909]

NMN is an NAD precursor, the whole point is to increase body NAD levels

[@alanchan8205]

Critical Findings From 12 Key NMN “Anti-Aging” Studies by Dr. Brad Stanfield. You will find evidence there.

[@murrmurr765]

I love Mrs. St. Claires

[@manuelojeda9144]

But if you cook with vegetable oils there will be inflammation and diseases. Ghee or beef tallow Will keep you healthy.❤

[@rustybolts8953]

i hope Dr. Sinclair has a change of mind on exercise and veganism.

[@guzalnormatova5561]

Where can I buy metformin and rest?

[@debbiedebbie9473]

Online

[@ritascolaro4059]

I had been taking NMN for at least a year. Had a heart attack, stopped taking it!

[@darwinmonzingo9738]

attempting to understand the health effects of ingesting purified charcoal or lump charcoal they fed mice an incredibly large ammount in there diet extending there lives by double. the last mouse was still alive when they terminated it to end the study. in ancient history those who consumed this as well were known as the coal biters and the most healthy and strong of all

[@worldofdaas]

health tracking is coming on leaps and bounds. We just interviewed Sam Corcos on this. You can watch the clip here kzbin.info/www/bejne/mKOTe6SEip2InNUsi=DMfHvey9zvn_44JS

[@Kuttanwarrior]

Safe if I take 250 mg Metformin, I wonder? I have no illness at all! SADA,INDIA.

[@lindaward8267]

I experienced do dizziness while taking MNM. Anyone else have this issue?

[@cmihalcea]

Don't forget to take TMG (trimethylglycine) with NMN

[@TheFoxisintheHouse]

Q I take a resveratrol and NMN combination at half the dose Sinclair does. I recently began upping the dose but do a split. 1/2 in the morning 🌄 and 1/2 in the evening. I also take a good quality MULTIVITAMIN along with it and drink lots of water 💧. Extra hydration is neccessary. It works great for me! Q ❤

[@albin2232]

The best thing for age reversal is element 115.

[@c.k.7361]

moscovium..??

[@aprilwood7473]

Isn’t NMN banned in America?

[@Astralox]

Oh hes back, Let me guess, hes wrote a new book...

[@soez_strg6166]

New product OTW 🤣

[@rohitkundu4596]

I don't know whether its his face for what, but he looks young

[@AL_THOMAS_777]

He wears a special thin rubber mask . . . .