Scientist on how topical supplement ‘reverses aging’ on our skin | Interview with OneSkin founder

[@myfuneralismytimetoshine]

$120 for a 50ml face cream? My goodness, and looking at the ingredients I'm really having a hard time justifying the price. Even if you would buy pracaxi, pau mulato, Grape, and Andiroba seed oil separately you would not come even close to the price. Being from Brazil I could easily buy 250 to 500 ml of these oils for a little less than 40 reais I understand the effort put into the product but what is the point if the majority of people can't buy it? I Don't get it.

[@thehonestchannel]

I hear you. I think the prices are particularly high on these more innovative products because of the R&D involved. Hopefully they come down in price (relative to inflation!) over time.

[@colleencolquhoun8818]

@@thehonestchannel ❤

[@NavilleT]

it's not that, it's probably the Decapeptide-52

[@myfuneralismytimetoshine]

@@thehonestchannel Hopefully, I love your channel by the way. Definitely the best out here!

[@myfuneralismytimetoshine]

@@NavilleT Decapeptide-52 is there mostly for pigmentation I believe, The oils are the highest in the ingredient list with means it makes up the majority of % on each bottle, water being the number one on the list. Even though peptides are fancy is just not enough of it on each bottle to justify the price for the amount you are getting. I think the product is probably lovely but not worth more than $65 -$75 and that is way up here already.

[@idahardy4052]

Hi - I’m catching up on all your fantastic videos. I just want to say that I tried this product - the one for the face and also the one for the body - and I saw no difference after six months and so discontinued using them. I turned 60 in February 2023, so when something says it can reverse aging, improve the health of the skin, and there’s some kind of science behind it and it’s not surgery, I’ll try it. I feel like six months was enough time to see change, and since I didn’t, I discontinued. Maybe others, like your Mum, will find that it improves their skin. I look forward to the update. Ida

[@thehonestchannel]

Thanks for sharing your experience, Ida. My mum loves the OneSkin moisturizer but you're not the first to say they didn't see a benefit. Six months is definitely enough time to try a new treatment out.

[@joyutmostjoylife9470]

I’ve used the face cream for 3 months. I can say my skin is acting younger, better bounce back and natural glow.

[@thehonestchannel]

That’s interesting to hear - thanks for sharing your experience with us.

[@bekind4329]

I am 59 and have used many products over the years this is the first cream that has actually done something. I have been using oneskin for 2 months, it took 3 weeks before I noticed a change. I will definitely keep using it.

[@thehonestchannel]

Great to hear! My mum is also loving it

[@valentina-pg4bj]

What changes have you seen, because I have used this product for 3 months & see absolutely nothing, unfortunately, but then again, I'm 75..

[@bekind4329]

@@valentina-pg4bj The change I have noticed is that my skin isn't dry anymore, I hardley ever use face cream anymore. I live in Canada and the humidity is so low. This is the first year I didn't even bother with the bedroom humidifier. I have also noticed a very very slight improvement in my wrinkles but definitely not a big change. The sagging skin hasn't changed. I am hopeful that the longer I use it I will notice more changes. Take care.

[@valentina-pg4bj]

@@bekind4329 Thank you for taking the time to respond, & I also use a humidifier in my bedroom every night because I live in the Arizona desert. I would continue to use OneSkin if they lowered their prices now that they are shipping a replaceable pouch for your container. So for me to pay $99 a month is just too much in my opinion, unless I saw a significant difference; which at this point I don't. Thank you kindly!

[@bekind4329]

@@valentina-pg4bj You are welcome. I totally agree I wish they would lower their price. My bottle lasts around 2 months and even that is expensive, plus the exchange rate for me makes it even more expensive.

[@e.foster9137]

I’m so glad I found your channel! I’m completely hooked

[@thehonestchannel]

Welcome! So happy to hear you’re enjoying my content ❤️

[@lindajoy23]

Thank you Clare for bringing us these new brands…..I was totally onboard until she mentioned “clean” 🙄 I can’t believe a scientist would use such a term, too much marketing & not enough science for me 😊

[@thehonestchannel]

Thanks Linda. ‘Clean’ is definitely one of those buzzwords right now!

[@itsinthedetails5007]

That also somehow ticked me off. I suddenly found myself at odds with the data, these women are throwing at us. They are now trying to get on the "Droplet" device. As oppsed to getting more data, and pushing their discovery,. Something stinks.This made me think, this is just BASIC skincare. The buzzword like "CLEAN' (being used up and down the Isle of the beauty industry), I want them to define this term, as Im tired of hearing this word bandied about like its some major find, but really it's for "Virtue Points" to push the brand, as "Clean Beauty" has MAJOR problems, in itself.

[@thedevilandhertrumpets4268]

@Linda Joy Agreed. She lost me at “San Francisco” based. I am immediately skeptical. (But so far love the content of this channel).

[@claudiaglows]

What a great interview! I actually love my OneSkin

[@thehonestchannel]

Thanks Claudia! I noticed you're a fan. Good to know you enjoy using it!

[@carolenmarch7445]

Hw do you know it's this that is making a difference; how are you trialling it to ensure this is the thing resulting in improvement? He are you objectively measuring improvement ?

[@toomanymarys7355]

@@carolenmarch7445 I was using everything else for a minimum of 3 months before I began. I had ALSO already done prolonged fasting with hit and run doses of grape seed extract and fisetin. When I started OneSkin, I got improvement specifically in the slight laxity that I had before. I'll do PRF in a year or two rather than adipeau, which doesn't impress me, but this does. I have better results with Dr Pen and peels using One Skin, too.

[@sophiebellavance5185]

Best Chanel watch you from Canada!

[@thehonestchannel]

Thanks Sophie!

[@kmj2000]

Ive been using oneskin for about 6 months. The fine lines on my face have definitely gone away. My crows feet have also reduced, but they're still there. I personally love it. It's expensive but a little goes a long way. I share one bottle with my husband and it has taken about 3 months to get through it.

[@thehonestchannel]

That’s great to hear. Thanks for sharing your experience

[@tatianaa.3694]

🤣

[@angel12boucher17]

I’m absolutely interested in this…the science is so important….the future is amazing in skincare…and anti-aging

[@thehonestchannel]

I agree!

[@LK2972]

Thank you, I really enjoy how thorough you are with your questions and how much easier it is to understand the aging process. Thanks again, love watching your channel 🥰

[@thehonestchannel]

Thanks Lorena! That’s great to hear ❤️

[@honeysucklewoes1627]

I used the oneskin body and for 6 months and I'm on the 7th month with the face. With the body cream, I used on 1 upper arm and shin, and used Cereve daily with ceramides on the other. After 5 months, there was no detectable difference between the 2 arms. They improved or looked worse in step with each other, depending on my hydration, how moist skin was, or if i'd tugged on it while showering or applying. There is no difference in my face. No change in lines, pores, sagging. My earlier pics look the same.

[@thehonestchannel]

That's really interesting to hear. Thanks for sharing your experience. My 80-year-old mum is using the face cream at the moment. I thought she would make an interesting test case!!

[@honeysucklewoes1627]

I'm 66 and figured Id be a great test case too! I'm looking forward to hearing your mum's experience. So far, no product that Ive tried, even 1% retinol nightly, has diminished a single line, despite a healthful diet and good habits. Vitamin C and BHA have both made skin softer and brighter, but that's it. I found the oneskin hype to be suspicious. When i emailed to unquire anout using the product with Vitamin C or other serums, the answer was so vague as to be useless. It was basically advice to do whatever i thought worked. When i asked what ingredients in their cleanser made it different and more effective than other cleansers, the response was commercial advertisement for what the product purported to do, but not an answer as to why it was better. Guess i can't expect much. I'm still waiting for more reviews with the same lighting and clinical studies. As mentioned, in vitro is not the same as in vivo.

[@toomanymarys7355]

@@honeysucklewoes1627 They answered my questions, giving the specific pH it's stable to. Don't use it with ascorbic acid.

[@jeffsplaylist2844]

@@toomanymarys7355 Thank you! So do you think that waiting about 20 min after applying CE Ferulic, or until it's no longer tacky, would be sufficient?

[@Angela-September]

I find this product exciting and did go through a couple of bottles (their packaging is really impressive now with the plastic only being part of your first order) - however I paused my subscription hoping they will come out with a serum version instead of the cream. Crossing my fingers!

[@thehonestchannel]

Thanks for sharing your experience Angela!

[@Lina126y]

I’m 65 and have no wrinkles or age spot just some slackness on the neck I don’t like lasers because I think that over time they harm your skin. It’s all about absorbing natural creams, eating well, intermittent fasting, sun screen, exercise and sleep.

[@pinadelmonico]

So I recently started the adipeau facial serum/cream but this sounds great too! I think I will use adipeau for several mos before adding or changing anything up. Thx for the info Clare!!❤

[@thehonestchannel]

Me too Pina. Think I’ll see how I go with the Adipeau first but I’m also interested in trying this out.

[@Lulu-kt6gr]

Do you like Adipeau?

[@thehonestchannel]

@@Lulu-kt6gr So far so good but I’m giving it a full 12 weeks of use before I take a view on the results. I’ll share that update in December.

[@pinadelmonico]

@@Lulu-kt6gr pretty good it’s only a few wks so I don’t notice any changes. It smells wonderful & feels very rich but not thick or heavy.

[@jeffsplaylist2844]

I was interested in the Adipeau, too. The before and after photos didn't impress me enough to try it. I'm eager to hear about your experience!

[@marleenscholte2738]

WOW, this would be amazing....price is too high for me but this is a new insight for me. Thank you!

[@thehonestchannel]

Hopefully we see the pricing of these innovative new skincare products become more accessible over time.

[@dguisinger]

The folks at Alastin have done a lot of extended interviews in the past, I feel like I've had great success with their products and they used punch biopsies in their studies. You should see if they want to chat.

[@thehonestchannel]

Great suggestion, thanks.

[@Hm-ye4em]

I spent over $300 on the bundle set and sadly what I noticed while using Oneskin were my forehead lines were becoming more prominant and it was making my skin itchy.

[@thehonestchannel]

I wonder if you reacted to one of the ingredients. I've not heard this from other viewers but unfortunately it can happen. I would write to OneSkin and let them know. Some skincare companies may offer at least a partial refund.

[@Hm-ye4em]

@@thehonestchannel That is a possibility! Thanks for your response :)

[@SkinObsessedMary]

Thanks for sharing Clare. Are you trying OneSkin yourself and reporting back? It's on my list!

[@thehonestchannel]

They have sent me a face cream to try so I will try to fit it in at some point. Be interested to hear what you think of it. I think Claudia is a fan.

[@lindsayfarquharson2446]

Unfortunately they didn’t ship to the uk. I messaged and they say they hope to ship internationally but don’t yet have a time frame on when that will happen.

[@thehonestchannel]

Yes, I hope they'll be able to ship internationally before too long.

[@juliafish8832]

I have been researching skin care for years including advice from my top uk plastic surgeon and excellent dermatologist. Nothing can penetrate deep enough through the stratum cornea; if it did it would be on prescription like Tretinoin etc.

[@thehonestchannel]

It's a good point, but while I agree that most skincare creams are unlikely to penetrate the stratum corneum I think there is good evidence to suggest some ingredients (including peptides) can and indeed do penetrate the skin barrier.

[@thehonestchannel]

@A C Agreed.

[@jodyjackson5475]

That is interesting when she asked her why she went into this area of research and development with her qualifications and degree , I said out loud duhhh ‘to make money of course, that’s why 🙄

[@jt-ob7od]

Isn’t it great?

[@MC-iw6nv]

Your skin relies 80% on what you eat/ your health on the inside, and only 20% on the outside (skincare), because skin is also an organ just like your heart, lungs and blood.

[@courtneyjackson4843]

I've used this product and I'm a longterm retin a user as well, so I started off with very good skin. I'm 43 and it took about 3 months use to see a difference. I would say this product and tretinoin are very close in terms of the effect. I can only afford to use this at night and use vitamin c in the morning though.

[@thehonestchannel]

Thanks so much for sharing your experience Courtney. What kind of difference to your skin have you seen with OneSkin?

[@carolenmarch7445]

Did you trial this desperately, or did you use in tandem with retin A?

[@stacyrlee]

Then it seems it would be a good option for those who can’t handle using retin A.

[@carolenmarch7445]

@@stacyrlee of you largely want to waste your money , yes. Better option if you can't handle retin A , but with proven efficacy is Tazarotene cream 0.1%.

[@courtneyjackson4843]

@@thehonestchannel less texture for sure. Still prefer my dermatica though more firming.

[@iis.1989]

My reaction when she mentioned ''EWG'': 😧

[@elenakatsari9882]

She lost me at clean products

[@lizelcariaga8717]

How about fat pads loss and bone loss in the face which are also very much part of the aging process? Is this face cream going to address that too?

[@aeducator1]

No. In their models they did not include fat cells.

[@philippillis9393]

Fat loss is probably the worst thing that can happen. I would suggest to look for volumizing bio stimulatory that are approved for fat loss in HIV positive patients like Hyperdiluted Radiesse and Sculptra.

[@seascape185]

there is a product and she did an interview with the D Scientist who invented it so llook back at playlist

[@seascape185]

It can’t penetrate unless you micro needle it it it won’t penetrate period

[@philippillis9393]

@@seascape185 yes apparenty some peptides work to signal cells to work better as a cascade effect but not by penetrating into the fibroblast

[@echase416]

Vitamin K2, Vitamin C, retinoids and Glutathione are some other anti-aging options

[@thegreaterconundrum]

Uh oh, right when she mentioned the EWG score I got skeptical 😭

[@amandaaustin4883]

When will they be shipping to other International destinations, specifically for me, to Australia? Thanks, great video.

[@thehonestchannel]

Hi Amanda. I’m waiting to hear back from OneSkin about when they’ll deliver more widely. I’m in the UK and would also like to be able to order it. I’ll update when I hear more.

[@susanthomson1331]

Hi Clare ..I love your videos and am grateful that your advice is so reliable . I would love to buy some Oneskin products. Can you tell me what website I should visit . Thanks Susie

[@thehonestchannel]

Hi Susan. So glad you find the videos helpful. I’ve included a link with discount code on the video description if you click ‘show more’ on the text box just underneath the video. Unfortunately they don’t deliver outside the US and Canada at the moment but I will update as and when that changes.

[@susanthomson1331]

@@thehonestchannel ok thanks Clare ..

[@theresamcdonald-smith5046]

Very nice moisturizer, but other than that, I didn’t see it do much. Went through 3 bottles. Disappointed.

[@thehonestchannel]

Thanks for sharing your experience, Theresa. It’s helpful to hear.

[@patriciahayes2790]

Unfortunately Bentonite is listed as an ingredient on the website - FDA have linked bentonite to heavy metal toxicity.

[@carolenmarch7445]

Unfortunately , the interviewer does not understand longevity science or scientific methodology and rigourous testing of products ( placebo controlled trials , cell line application limitations , longitudional studies etc ). This makes it easy for such an individual to discuss and promote such products without solid evidence that they produce visible results (without showing statistically significant results or any results that can be quantitatively measured in a robust way ). The skin is a barrier , it does it's job well and rightly so . Many products are too large to go beyond the dead corneal layer, unless the skin is perforated. No entry ! Save your money ladies, or if you do want real results try exercise , good sleep hygiene , Mediterranean diet and oral MNM, T.MG , vitamin c and marine collagen ...now that'll blow the socks off anything this line of hyperexpensive largely / very minimally delivering product line . Add to it return A , and sun screen .You'll see results in 4 -9 weeks , age / health dependent. weeks

[@chrismahfouz7709]

Link to the product (OneSkin) talked about doesn’t work for me. Has anyone else not been able to use the link? I’ll try again later. Enjoyed the talk! (As always!) Thank you!

[@thehonestchannel]

Hi Chris. Sorry, I should have checked that. I've updated the link in the description now.

[@littlevoice_11]

Were the studies against a control? For example, even a topical moisturizer and uva/b to show reduced wrinkle depth.

[@consciouscrypto3090]

I don't know if it is the lighting or something in this video, but your skin does look improved from when you first did the Adipeau videos. Seems to definitely be working. I think I may do that one for my lower face and this one for my upper face, so I can test them at the same time. Really I need the fat/volume lower and wrinkle removal upper, so that works out for me. Thanks for helping me find these. Btw, your coupon code isn't working.

[@thehonestchannel]

That sounds like a good approach because the Adipeau isn’t as effective on the forehead and temples but seems to work better under the eyes and on the cheeks and jowls. Is it the OneSkin code you’re having trouble with or Adipeau? The OneSkin code only works on one-off orders rather than subscription.

[@consciouscrypto3090]

@@thehonestchannel The Adipeau one worked. It was the OneSkin that didn't. Probably because I first did for subscribe, then switched to one off. Cookies probably made it still not work.

[@thehonestchannel]

@@consciouscrypto3090 Shame you didn’t get the discount!

[@donnavalenza6961]

If we have other serums we love using, can you incorporate one skin with them, and if so how do we ?

[@thehonestchannel]

Hi Donna. There's advice on how to incorporate OneSkin products into your routine in the FAQ area on the site. This is what it says: At their core, our Topical Supplements are moisturizers, so we recommend applying them after cleansing and before sunscreen. OS-01 FACE and OS-01 BODY have not been shown to produce adverse reactions with other products and ingredients, including retinol, vitamin C, and hyaluronic acid. This means that you can safely incorporate them into your current routine without any additional changes. To learn more about how to integrate OneSkin into your current routine,

[@catherine7890]

Interesting video. Just as a video suggestion, have you looked at Kleresca Rejuvination treatment? It's meant to increase collagen by up to 400%. I would like to see an honest review of it.

[@thehonestchannel]

I’ll make a note of it. Thanks for the suggestion!

[@investigativereports1622]

We have been using One Skin, Since day 1 of their product launch!

[@thehonestchannel]

Have you seen good results with it?

[@mimimoon6082]

Would love to hear your thoughts on your experience, please.

[@despoullapantelaki2479]

Where in Europe can I purchase these products for delivery to Limassol Cyprus? Thank you

[@thehonestchannel]

They don’t seem to be available outside North America at the moment but I am waiting to hear back on when that might change. I’ll update when I know more.

[@ongoingawakening4257]

There’s a hack for pricing. Choose the subscription. The product actually lasts 6 weeks or more. Make it last. Target usage of body cream making it last. Stretch it out. Also many women stop using all the other products and focus on this most restorative technology. That’s how I’m justifying the cost.

[@thehonestchannel]

Great tip. Do you use the body cream for your face? My mum loves this stuff.

[@ongoingawakening4257]

@@thehonestchannel I use body cream everywhere but face.

[@christinanoble2110]

Shipping is only available in the US and Canada, when will it be available in the UK?

[@thehonestchannel]

Hi Christina. I'll find out for you. I'd also like to start using this product.

[@MilenaMNowak]

@@thehonestchannel Also interested :) I am based in Germany. Thank you

[@lovingit1538]

Is one skin coming up with an internal supplement??? Thank you

[@williammoor3069]

I am a 79 year old female and products with HA cause breakouts for me. Did I understand from her that there are different levels of HA so this may work for me?

[@thehonestchannel]

The supplement does contain hyaluronic acid so if that's something that causes breakouts I couldn't say whether this product would be any different I'm afraid.

[@lindajoy23]

You could try Adipeau, it doesn’t contain HA. Watch Clare’s interview with Ivan from Adipeau, I was convinced enough to try it and am seeing some improvements in my skin. Also ships worldwide and not outrageously expensive

[@thehonestchannel]

@@lindajoy23 Great to hear you’re seeing results with the Adipeau Linda. Hopefully the discount codes help a bit with costs too.

[@lindajoy23]

@@thehonestchannel Thanks Clare, I used the discount code on my first purchase and received a complimentary bottle with a lovely letter from Ivan. I’ve since purchased another bottle to have a back up but forgot to use your code 🙄

[@pixiepup8]

What peptide is being used in this product? She didn’t say.

[@marleenscholte2738]

Do you test One Skin out, Clare?

[@thehonestchannel]

Not yet Marleen, though I would like to try out the topical supplements after using Adipeau for 12 weeks.

[@marleenscholte2738]

@@thehonestchannel Yes I'm very curious about you're Adipeau testing for 12 weeks.

[@thehonestchannel]

@@marleenscholte2738 Not too long to wait now! There are a few viewers who’ve been using it who have started to leave feedback in the comments of the first video. Seems positive

[@marleenscholte2738]

@@thehonestchannel ooh I will look up the comments and wait for yours, on top of that they don't send to the Netherlands yet

[@Steven-ze2zk]

Are face exercises worth doing? I'm overwhelmed by the amount of information there is on the subject. There's face massages, face yoga and face aerobics to name but a few. I can't find a plausible approach or feasible routine for me. It's worse than skincare and skincare is insane! Face scrubs, serums and everything else. I don't know where to begin. Today I purchased a simple (literally, the company is called, "simple") face wash for less than £3. I guess it's a start and I'll see how I get on. Next I'll add some night and day moisturizer along with some sun screen. Later I'll grab some vitamin c serums and eye serum. After that I'll include some retinol. If all of that does not get rid of my crow's feet and forehead lines I don't know what I'll do beyond once again braving the world of face exercises.

[@thehonestchannel]

It’s an absolute maze isn’t it. The jury is out on face exercises in that they can cause you to lose volume due to reduced facial fat. A dermaroller is a good idea, along with a retinoid, vitamin c serum and sunscreen. Less is more!

[@connietank2568]

I ordered this product but have not received it nor a shipping date. It has now been 8 days and no shipment from this company. I have decided to cancel.

[@thehonestchannel]

Sorry to hear this but thanks for sharing your experience.

[@bonniehaigh8579]

Great video, thinking of trying this cream/serum but is is expensive expecially when you have to pay the amount in CDN Funds, for me it will be another $50 over the US Price.I can't use retinal so might be worthy a try. For me, "Less is More". I have been using Vit C from Protocol lab and their moisturizing cream. Do they olfer a starter kit.

[@strawberrycupcake4471]

Hi, where do I buy this? I have checked the website and it says it does not ship to the UK....Have you got any licenced stockists here in England, would love to try this. Thank you. x

[@thehonestchannel]

Hi. I'll find out for you and let you know.

[@dreamerboy24]

This was fascinating, thank you! I’m intrigued about the oral longevity supplements that were alluded to. Can anyone share what those are? From what I’ve culled from the comments, I think fisetin, NMN, and TMG perhaps? I’m so exhausted from pouring money into useless supplements that end up turning my cupboards into pill graveyards so would like to focus on ones that are evidence-based.

[@thehonestchannel]

I know exactly what you mean. NMN is the main one but it has recently been banned as a dietary supplement in the US. I take Tru Niagen every other day. I only recently started taking it and it’s pretty expensive but is the most evidenced. That and high strength vitamin D.

[@kerrystone3201]

Yeah I agree trancedimi. Getting to the truth is bloody exhausting alright. You really have to be persistent to get to the bottom of it. It can be very confusing, especially you're not awesome at interpreting the data/findings. Even the experts don't know half the time I reckon... haha.

[@stefanisilva2493]

Curently in aesthetic pharmacy we are talking a lot about Pinus Pinaster extract and Polipodium Leucotomos extracts.

[@littlevoice_11]

Nmn, collagen type 1 and 3, Omega 3, glycine. Diet wise: the anti inflammatory diet that is lower carbohydrate to ensure stability of blood sugar. Avoiding alcohol, fried food and processed food. Time restricted eating also seems highly effective.

[@annethomas4112]

When can we get this in England?

[@thehonestchannel]

I have asked the question - still waiting for a response but I'll update as soon as I have one.

[@deborah3912]

all I want to know is is there a money back guarantee if their product doesn't work

[@thehonestchannel]

Not that I can see on their website!

[@wadenyoost1796]

I am heartbroken. That HONEST15 code does not work!!!!

[@thehonestchannel]

Oh dear. It’s been working fine so far. It can only be used once per customer and on one-time purchases but I can ask OneSkin to check it out. Sorry about that.

[@wadenyoost1796]

@@thehonestchannel I see what the problem is. I was trying to become a subscriber and get the additional discount. Okay. Thanks anyway.

[@thehonestchannel]

@@wadenyoost1796 No problem!

[@Whatsupbuddiebud]

Your link doesn't work

[@thehonestchannel]

Sorry for the late reply. I've just updated it now - apologies about that. glnk.io/0my3l/honestclare

[@acollins910]

Alarming to see someone with scientific training spout fear-mongering mumbojumbo about “clean products.” I am intrigued by OneSkin but this interview convinced me that it’s likely snake oil.

[@NinorahDeux]

3 months of daily use of the body lotion, ZERO result.

[@thehonestchannel]

That's disappointing, but thank you for sharing your experience.

[@NinorahDeux]

@@thehonestchannel I have to add that they never published my bad review on their website (i tried twice and was very polite, just saying: "no results for me"), and if you check, their pictures "before-after" are alwyas taken with a different angle, so for me it's a scam.

[@ErinLovesJim]

I was compelled by this interview and searched reviews. The reviews on Amazon are so blatantly fake. Some say the EXACT same thing and many reviews have fake-sounding names of reviewers and when you click on them this is the only product they have reviewed. Seems very scammy. Love your channel, though!

[@thehonestchannel]

Hmm. I believe the research behind this product is genuine, but it is very off-putting when reviews sound cooked. Thanks for flagging.

[@vetsai8199]

I’ve been using this stuff FAITHFULLY, twice a day for six months. I give every new supplement or topical treatment six months to prove itself. But I have to say, at the end of the six mon this, if I don’t see any difference, in the slightest, I will not continue the product. Therefore, after I finish my sixth container of Oneskin, I will cancel my subscription.

[@thehonestchannel]

Sorry to hear it’s not worked out for you and thanks for sharing you experience with this product.

[@ivydune4185]

Another $100+ product that needs to be bought frequently and results may vary. I'm a little tired of this industry. They all sell uncertainties at certainly high prices.

[@magickmagazine7675]

What is the active ingredient everybody talks around it - we’re gonna talk science and let’s talk active ingredient

[@thehonestchannel]

The key active ingredient that she discusses in the video is their proprietary peptide. On their site under the product listings they include details of six other supporting active ingredients including oleic pau mulato extract, niacinamide, pracaxi and andiroba oil. I would have liked to have drilled into the ingredients a little more with Carolina but her time was limited.

[@magickmagazine7675]

I assume it would be mitochondria-encoded peptides humanin, MOTS-c, SHLP2 and SHLP6. www.ncbi.nlm.nih.gov/pmc/articles/PMC6046248/ Cellular senescence is a complex cell fate response that is thought to underlie several age-related pathologies. Despite a loss of proliferative potential, senescent cells are metabolically active and produce energy-consuming effectors, including senescence-associated secretory phenotypes (SASPs). Mitochondria play crucial roles in energy production and cellular signaling, but the key features of mitochondrial physiology and particularly of mitochondria-derived peptides (MDPs), remain underexplored in senescence responses. Here, we used primary human fibroblasts made senescent by replicative exhaustion, doxorubicin or hydrogen peroxide treatment, and examined the number of mitochondria and the levels of mitochondrial respiration, mitochondrial DNA methylation and the mitochondria-encoded peptides humanin, MOTS-c, SHLP2 and SHLP6. Senescent cells showed increased numbers of mitochondria and higher levels of mitochondrial respiration, variable changes in mitochondrial DNA methylation, and elevated levels of humanin and MOTS-c. Humanin and MOTS-c administration modestly increased mitochondrial respiration and selected components of the SASP in doxorubicin-induced senescent cells partially via JAK pathway. Targeting metabolism in senescence cells is an important strategy to reduce SASP production for eliminating the deleterious effects of senescence. These results provide insight into the role of MDPs in mitochondrial energetics and the production of SASP components by senescent cells.

[@magickmagazine7675]

The oils must just be a carrier base - as it is impossible for an oil molecule to penetrate the skin - on top of the skin will Give the outside cuticle of the skin a softer feel - they do not penetrate - very unusual that she should use an oil base for a Peptide - it is interesting that a lot of the skin care companies now Are not hiding their active ingredients - they are Openly discussing it with their intelligent consumers - as consumers not only wants to know about the active ingredients - which are protected by patent - they also want to know about quantities that the cream contains of the active ingredient - example the ordinary company - they have multi peptide serums - and they’re happy to discuss all of their ingredients - they have informed consumers - No fancy advertising or packaging and keeping peptides very low priced

[@thehonestchannel]

@@magickmagazine7675 I appreciate your insight. Thank you.

[@maryabraham9182]

Hi I am a new subscriber😊 I was looking for how to increase fat in the face , and I saw the video you were talking to professor IVAN GALANIN….. I wanna know your results how it’s gonna be after three months I hope it will work , if it does please let us know so I can order it,thank you so much🙏🏻🙏🏻💐💕🥰

[@thehonestchannel]

Hi Mary. Welcome to the channel! I’m delighted to have you as a subscriber. I promise I will share an update next month with my results. In the comments section of the first interview with Ivan some viewers are starting to share their experiences of using the cream and it’s sounding pretty positive!

[@maryabraham9182]

@@thehonestchannel I can’t wait for the result I !! am 52 and going through menopause I start losing a lot of fat in my cheeks and under my eye actually all over my face at the same time I have saggy Joel to I don’t want to do any fillers I just want things natural so I hope it will work 😊🥰thank you so much and God bless you🙏🏻🙏🏻💕🌺

[@NM-qc2dh]

So you don’t think she recognised the anti aging epidemic and wanted to make a stash of money and that’s why she went into this field. What a waste of time!

[@user-fw6hn1wu6r]

This product does not create any difference in any aspect of skin. USED IT 6 MONTHS Thanks David Sinclair - Another blunder of his. Did the face cream 3 bottles and 2 bottles on my body. Super expensive and zero results. Keep working Carolina!!!

[@thehonestchannel]

Really sorry this didn't work out for you. In years to come we will be able to buy peptide-based creams and serums that are formulated according to the types of peptides our skin particularly lacks and could benefit from replacing. At the moment though, we have no way of analyzing that and therefore telling which peptides are best suited to our skin. It means someone like my mum can see great results with a product like this and another person zero. Frustrating, I know.

[@carolenmarch7445]

Typo ...NMN !

[@BilalDemiroglu]

Goodmorning my love nice enerji bravo dear l love yuo my love

[@thehonestchannel]

Thank you!

[@wulfsorenson8859]

Sweetie just stop wasting money and get a face and neck lift. Stop wasting money on gimmicks and topical supplements with questionable efficacy. These people are just after your money. You look every bit your age and anyone telling you otherwise is lying. Surgery is the only thing that works once you reach a certain age.

[@thehonestchannel]

I always appreciate honesty 😁 I turn 50 in February and i’m happy with the way I look. If I look my age that’s great - because I feel vital and energised. I’m not chasing eternal youth and I’m not interested in surgery. I want to live, look and feel well for as long as I can. That’s it.

[@wulfsorenson8859]

@@thehonestchannel well you obviously are trying to look youthful that’s why you spend money and make videos on multiple procedures 🙄. If you want real life results which will knock years off you I suggest you save money towards a deep plane facelift by an excellent surgeon. Do research on RealSelf and go for multiple in person consultations. These non invasive treatments are very expensive and produce no or minimal results and in some cases like with Ultherapy they can have horrible consequences. Also I guarantee your channel will get much larger if you made videos documenting your surgical journey.

[@thehonestchannel]

@@wulfsorenson8859 I’m happy with how I look for my age and enjoy exploring skincare innovations. I don’t want or need surgery but I appreciate your point of view.

[@lynne4406]

@@thehonestchannel I actually had a facelift. Wish it was a deep-plane one though, as I learned it wasn't. I do look about ten years younger but not just like I looked ten years ago. There are other reasons we look old, not just wrinkled skin. What about bone loss? The orbital area gets larger, and the bone's density decreases.

[@thehonestchannel]

@@lynne4406 Absolutely. Aging well has to be a whole-body approach, not just skincare.

[@sterlgirlceline]

⭐️⭐️⭐️⭐️⭐️⭐️

[@sofia2moro]

Nice advertising ..

[@thehonestchannel]

Not paid, just interested.

[@ronu7313]

Before after ain't that impressive there are things available now with much impressive results, do your homework

[@thehonestchannel]

To be fair, this shows results from a body lotion in a case of pretty advanced aging. But the reason I interviewed Carolina is because I think products like hers point to the future direction of skincare and I find that fascinating.

[@SheikhAlladeen]

they have a Link on their site from Forbes that leads to an unrelated article. This sounds like a hoax

[@thehonestchannel]

Well number 1 I'm a journalist of over 25 years experience and I'm not going to invite someone onto my channel whose business I have not researched. Number 2, the article is totally related. If you read it there's a section in which the doctor is asked about any interesting research in skin aging that she's particularly excited about and she talks about OneSkin's work.

[@SheikhAlladeen]

@@thehonestchannel Well Iam sorry pls provide the text in the FORBES article where OneSkin is mentioned. Also Dr Sinclair is unrelated also Tony Robbins is unrelated the others are Business Promoters. Number of Employee Profiles 4. 4 Phds ? Anybody can be a Phd in the US I am a Phd in religious science bought it for 50 $ Took me 4 min to find out this is are 4 people trying to get some cash this is no company with R&D or anything.

[@thehonestchannel]

@@SheikhAlladeen Copied and pasted from the Forbes article: Is there any interesting research in skin aging that you are particularly excited about? I am very interested in the translational science being conducted by a couple of groups who are focusing on the role of senescent cells in skin and how this can be targeted to reduce inflammation and slow the aging process. One group is Oneskin - the CSO, Alessandra Zonari presented their initial data at the Science of Aging last year. They are a team of four female scientists who have identified a peptide and generated ex vivo data suggesting that it reduces the accumulation of DNA damage and prevents cellular senescence.

[@thehonestchannel]

@@SheikhAlladeen And on the other two points. OneSkin is discussed in the Dr Sinclair podcast that is linked. I'd recommend you listen to it because it's highly informative. The Tony Robbins link is to his book which I've not read but am presuming they're in it which is why they've linked it.

[@SheikhAlladeen]

@@thehonestchannel wow it took me one hour to find it among 100 others mentioned..I am very interested... who have identified a peptide and generated ex vivo data .Great good luck hope Tony Robbins and Dr Sinclair really talk about them one day.OneSkin operates end-to-end R&D in-house with a team of experts in stem cell biology, skin regeneration, tissue engineering, biochemistry, bioinformatics, molecular biology, immunology and aging. They measure skinspan in with MolClock - OneSkin’s first skin-specific molecular clock - and with skin aging modelling, using a proprietary technology and lab process which includes growing 3D human skin weekly and measuring how various products and ingredients influence gene expression of the many genes associated with aging and Longevity.Number of Employee 4 super human