Season 8 Episode 5: Unexpected Benefits of Terzepatide (Mounjaro, Zepbound) in Treating Hair Loss

Welcome to the latest episode of the Evidence-Based Hair Podcast, hosted by dermatologist and hair loss specialist, Dr. Jeff Donovan. As the director of the Donovan Hair Academy, Dr. Donovan is dedicated to educating both the public and hair loss practitioners about the complexities of hair loss.
In this episode, Dr. Donovan delves into a fascinating study from JAAD Case Reports, which explores the potential benefits of the diabetes drug terzepatide for treating androgenetic alopecia. This groundbreaking case report suggests that medications targeting insulin resistance could offer new strategies for hair growth.
Join Dr. Donovan as he breaks down the study, discusses the implications of using GLP-1/GIP receptor agonists for hair loss, and highlights the importance of understanding the metabolic connections to androgenetic alopecia. Discover how these findings could pave the way for novel treatment approaches and what it means for patients worldwide.
Whether you're a practitioner, researcher, or someone affected by hair loss, this episode provides insightful perspectives on the future of hair loss treatment. Tune in to learn more about the potential of terzepatide and similar medications in addressing hair loss challenges.
STUDY REFERENCED
Gordon E, Musleh S, Bordone LA. Treatment of insulin resistance with tirzepatide leading to improvement of hair loss. JAAD Case Rep . 2024 Jun 11:50:123-125. doi: 10.1016/j.jdcr.2024.06.001. eCollection 2024 Aug

[@weeteelim3749]

As usual a highly objective analysis

[@kamihiniku6548]

Thank you so much, it’s interesting to hear about these diabetes / weight loss treatments. I have been diagnosed with diabetes (insulin resistance), probably caused by long term use of dutasteride. I have high blood pressure as well, but a perfect BMI. Currently on metformin and hoping it will somehow help with hair loss as well.

[@copetillirope178]

hi doctor sorry to bother again but i read than isotretinoin could alter vitamin a metabolism signaling and alter ppar in a negative way so i was wondering if doing isotretinoin 3 or 4 times per week could be harmfull for lpp or if it was a decent add on ( as it's a first line treatment for ffa). and for someone who doesnt respond to anything inyour practice have you seen decent results with pioglitazone? thanks you very much

[@donovanmedical9780]

10 years ago, a brilliant doctor and I studied the use of isotretinoin in LPP. Sure it is an option but no it does not help everyone. Be sure to speak to your own doctor as I have no idea if this is a good and safe choice for you or not (as I don’t know your story). Yes, pioglitazone is an option but I don’t like this drug all that much for reasons again you’re going to need to chat with your doctor about (bladder cancer and heart effects). pubmed.ncbi.nlm.nih.gov/25437967/

[@donovanmedical9780]

Do you see my answer below? @copetillirope178

[@copetillirope178]

@@donovanmedical9780 i can see this comments yeah but i don't see the one with the linked study . thank you very much