Should healthy people take metformin? (benefits vs. negative exercise effects) | Rhonda Patrick

[@FoundMyFitnessClips]

Listen to the full episode on the Kevin Rose Show: podcasts.apple.com/us/podcast/dr-rhonda-patrick-new-omega3-sulforaphane-research/id1088864895?i=1000461297039 More clips from Dr. Rhonda Patrick: kzbin.info/aero/PLrGxo-5Uw8gJAebLkHTAf09y4i7g8Hag8

[@aubreyj.tennant1123]

Thank you!

[@JoseChung21]

Can you update us on your current view of metformin?

[@brianfenech10]

If you are not diabetic and just taking metformin for longetivity, don't take on exercise days as it reduces performace as well as inhibites protein synthesis. Take on rest days 24 hours before your next training session, and take the fast acting metaformin. Also you can take Berberin instead.

[@MY999-v4c]

I have used 500Mg metformin two or three time a day since 3 months ago. I am a healthy person but I am lazy and never exercise, I am addicted to carbs. Metformin is my life saver. I could eat normal amount of food without craving too much and I lost 15 lbs.

[@MustanveerIzna]

Thankiou i needed to hear this❤

[@poohbear2441]

After I turned 43 Its been so hard to loose weight and I don’t eat a lot but I have gained 15lbs within 2 years:/ I tried diets and exercise but its soooo hard for me to loose weight!! My sister suggested metaformin so today is my first day. I am hoping to loose 15-20lbs! I am hoping this will help with my hormone.

[@MY999-v4c]

Updates: it’s been a year now! I successfully lost 20 lbs. I am on gluten free diet plus 500 mg metformin every day.

[@wisemansaid5009]

​@@MY999-v4cyour calories intake before and after starting metformin

[@wisemansaid5009]

​@@poohbear2441 any update?

[@usayeed727]

I’ve been taking metformin (500mg-1500mg per day) for the past two weeks. I’ve noticed some quicker fatigue accumulation during my training but I’d say its negative impact is maybe 5%-10%- it isn’t enough to be super significant. I’m still making strength gains but, more importantly, I’m finally losing that stubborn excessive body fat that I’ve been struggling the offset since covid first began. I combine it with a 17:7 intermittent fasting protocol and it’s helped improve my overall quality of life. I think unless you’re a professional athlete who’s main source of living is that, you don’t have to worry about metformin and gym performance. If you’re interested in muscle and strength gains, just don’t take it on a bulk.

[@ProteinBadger]

Incredibly helpful! Thanks a bunch!

[@robynhope219]

Would u recommend metformin for chronic fatigue? I only take 500 mg/day and feel nauseous most of the day. I am an elder and take it bc of my broken metabolism..thnx.

[@johnlockett1565]

Thank you for this video. I am 81 and I do take Metformin. My diabetes 2 started about 10 years ago. My Dr. and I starting working to change that outcome. I started taking Metformin 1000 mg, exercising and dieting. My weight was about 88 kgrms.. I am 5'.7". I started exercising on a treadmill. (Set at 3 which at a higher point I will start to run), 30 minutes 6 times a week. The Metformin reduced my appetite so much that after 18 months the doses went down to 500mg. After about 30 month I starting loosing weight and I stopped at 75 Kgrms. My diabetes 2 disappeared, but I still taking Metformin. This medication still affect my appetite, so I stop taking it for about a month and restart again. Dr. for me it was the exercise and loosing the weight. 75 kgrms is my weight when I was 21 years old. Metformin help me by reducing my appetite and now I eat smaller portions. I think it is all about the weight.

[@PANOS5656]

30 month?

[@johnlockett1565]

@@PANOS5656 #30 month? Just take it for 30 month and then stop. What I said is about it. Keep using it and stop when you think you should.

[@PANOS5656]

@@johnlockett1565 So you lost that weight in 2.5 years, correct?

[@johnlockett1565]

@@PANOS5656 I would say 2 to 2.5 years of working out methodically, reducing portion sizes. I am convinced that if you go back at your weight in your teen years. I had a small Michelling around my stomach that is all gone. Weight control is the key. Nearly everything we eat turns to sugar, so small portions too.

[@cesschartz7813]

​@PANOS5656 thank you for asking same questions I had too.❤

[@fayiz_shaffaq]

She’s got answers to almost every question I have

[@roblovegreen]

The body is so complex and it’s self regulating when it works right. When it’s not hindered by toxins or deficiencies and gets regular exercise and sunlight.

[@neilsant1194]

Dr. RHONDA'S thought conclusion after analizing all trials is that "there is no substitute for EXERCISE". Though MEtformin really can help esp those who have pre/type 2 diabetes.

[@MrDonniemaclennan]

I give up.There is so many contradicting videos out there on anti aging suppliments . Its just all too confusing

[@Wonderland41]

It would help if she actually had any facts in front of her and she wasn't making such generalizations.

[@denis4697]

Basically metformin is good for life extending and health overall. When medication is too good, it needs to be stopped for the general public. I am a non-diabetic, using once a day metformin for months. Yeah... i dont see how metforming DOESNT help me with physical training. Feel good, great shape, no fatigue. So yeah... shills gonna shill i guess

[@ShinySilverBunny]

@@denis4697 thank you for this comment I started it today for PCOS and insulin resistance and weight loss.

[@laartwork]

I am surprised that there isn't that much contradictory videos. Yes you get the same positive effects by cutting out sugar from your diet and excersice without any of the possible side effects..... so there you go Americans. Cut out sugar and excercise (or take a pill).

[@keysersoze1537]

This is because everybody thinks they know it all, none have don’t shit so they just reading and repeating what they read. Like in Best Buy when they read the info card to you as if they know the specs on that tv lol you can figure that out

[@jtschnow9253]

I have/had type 2D and have been on 2000mg of metformin for 2 years. I lift weights and it has turned me into a beast. I believe metformin + weights has a synergistic effect. Current AC1 6.1 down from 10.4.

[@jeffreyhogueison8560]

I take metformin 500 mg I have had no problem with High intensity exercise or any bad thing they are talking about here I have not experienced any lost yet. Same as you. Maybe because we been taking it for quite a while we are adapted to it.

[@neslisultan]

Hey guys I’ve seen an improvement in my training as well. Not even the same, an improvement. Maybe something to do with our mitochondria, gut bacteria... I don’t know.

[@neslisultan]

I’ve been taking merformin for 7 months and it’s greatly improved my health and training. I’m sure the training improved as a result of my health improving although I’m not sure. I’m training harder, feeling stronger and have more endurance, needing less caffeine, dropping weight and haven’t seen any negative effects to muscularity. I have not done anything different besides add the merformin and don’t take any other chemicals.

[@Nilsosmar]

Nelly E, do you take the metformin every day? Or skip it on your exercising days?

[@neslisultan]

Nils from Alaska i was taking it every single day and didn’t even know I should skip training days. But the last 2 months I’ve been skipping days for training. Problem is I’m training 4/5 days a week 🤦🏻‍♀️ I hope it still works the same/better.

[@nissirapatricia5795]

@@neslisultan Are you taking metformin in the morning or evening?

[@AL_THOMAS_777]

@@nissirapatricia5795 Every such substance should be taken in the morning since you need an early kick for going / staying t o u g h through the (stressful) day. And second: please do not forget that your liver 4 sure is on s t a n d b y in the night. That all has 2 be considered. Greetings from europe :D

[@nissirapatricia5795]

@@AL_THOMAS_777 Thank you. I am also from Europe :)

[@michaelworley8866]

I'm jacked and cardio is amazing , been taking metformin for its health benefits for 7 years. ZERO impact on my fitness progression ,if there was a impact its miniscule . haha her acting like all these people are pushing themselves hard enough that metformin is going to have a serious impact and hold them back . Girl they got to get off the couch first , they got to get their diet in check first lol. Real life experience is sometimes better than information overload .

[@maidakhan6974]

How much metformin are you taking if you don’t mind me asking ?

[@SquatFull]

If metformin has negative impacts on mitochondria and skeletal muscle, then does it make sense to use metformin when resistance exercising to minimize sarcopenia?

[@thechad6218]

It will lower your IGF-1

[@Fomites]

Clinical trials ARE real life experience. ONE anecdote is almost meaningless.

[@nicholaskoenig3106]

I was looking for this sort of reply before I typed one in! I TOO am a monument to physical perfection 😂 seriously...but I love lifting heavy and biking in the woods. Never gets old. #goodwork *Edit: oh and Ive been taking metformin for 3ish yrs (500migs)

[@joelmccoy9969]

Dr. Rhonda Patrick has upped the quality of the nutrition conversations of English speakers. This is great.

[@蔡哲光]

500mg metformin and 500mg niacinamide in the morning, moderate exercise and pre-breakfast exercise/stretch seemed work well for me!

[@蔡哲光]

by the way, I lost 25 pounds in 8 months from 177 to 151pounds, A1c from 5.5 to 5.2, fast glucose from 103 to 95.

[@蔡哲光]

and I am 5 ft 9 inch tall.

[@marioarias9942]

My doctor recommends taking with dinner.

[@Gabriel1o1]

2 years later, how do you feel about your protocol and the impact on general health?

[@E-Diva]

​@@蔡哲光are you still doing this protocol? Niacinamide for cholesterol?

[@MrRawnerves]

That’s incredible to hear, the point about healthy people who exercise taking Metformin. According to Dr. David Sinclair , who uses it personally in a study he is conducting within himself has stated that there is a synergistic effect. However, he understands that the pharmaceutical industry is the main cause of wrong dissemination of information. So who should we believe? I’m with Dr. Sinclair on this one. I am willing to conduct my own personal study under proper medical supervision. What do I have to loose? The potential to live 15% longer, healthier is a good incentive.

[@moestietabarnak]

I think metformin simulate fasting.. I'll try fasting first...

[@ariangoleh]

I’m with you on this one and have seen all Dr Sinclair’s podcasts specially Joe Rogans and it hurts me to see just because aging is not a Disease FDA doesn’t approve over the counter buy, and I’m still very confused over metformin infos some Doctors are so pro Met and some are 100% against it don’t know if I’m going to take it or not

[@MrRawnerves]

@@ariangoleh How many friends of yours ( mine too ) got Viagra prescriptions when they didn't need it? 😉 Doctors didn't question these men. Why then should doctors question us if we want to get a prescription for metformin?

[@Preppygrwm-c3z]

As a medical professional with prescriptive authority, I applaud you on your comment. Doctors overprescribe many medications if it is a standard of practice. Why not metformin then.

[@CK8652]

I am 39 and play soccer several times per week and work out almost everyday. I started Metformin for the increased cognitive and general longevity reasons. My first soccer game on Metformin I noticed a huge decrease in performance. I was out of breath very quickly and my legs felt heavy and weak. I found this video and am sure it did affect my performance, drastically. I will wait until I’m old and out of competitive sports before trying Metformin again.

[@xseeyah]

You sound like me. Do you do legs (squats, dead’s, etc) on a game day?

[@CK8652]

@@xseeyah No, I should delete this comment. I have been taking it for months now and don't notice anything. I believe I was dehydrated that day. Metformin is amazing, I love it.

[@xseeyah]

@@CK8652 Have you noticed Metformin impact your performance on the field, at the gym or work? If so, how?

[@CK8652]

@@xseeyah No, if anything it's better all around. My mental focus and the ability for words/responses to come quicker when talking has positively affected social/work life. Haven't noticed any problems at the gym or with soccer works good with creatine. I initially tried it after covid left me a little "foggy" upstairs and I read that it helps - and it does. Also, I was borderline pre-diabetic and used a CGM to see 3ounces of white rice could spike me to 190, now if I eat a giant slice of cake I still don't barely hit 140/150. It seems to be all upside for me, and I will continue it primarily for mental performance reasons among the other benefits.

[@adrianmcneil584]

I’m not diabetic but I take it. It makes me a little lazy so I take it right at bed and Im good by morning. I should add that Dr.David Sinclair recommends taking it just 2 or 3 times a week.

[@tonehernandez8598]

What benefits do you notice ?

[@fantasticallyfit6030]

I’m 55 and am a natural fitness competitor. I’ve been a consistent exerciser since is was 18. I’ve never been fat. I’ve always been lean. No inflammatory marker. Yet A1C is 6.0. So I have been using metformin for 3 days. No negative sides so far. I feel no difference in exercise performance so far.

[@RayRomanMedia]

Update?

[@hiyacynthia]

Hi, did you try just changing diet? That’s what I’m doing with help of a CGM

[@ro_nbjj6825]

Any update?

[@fantasticallyfit6030]

@@hiyacynthia I’ve been keto/carnivore since May 2021

[@fantasticallyfit6030]

@@RayRomanMedia doing well. My A1C was just tested at Lab. It was 5.5. However my CGM has me at 4.8. So I’ll take it. I’m still keto with very occasional carbs up to 50 grams. Strength is up.

[@kram21]

Have taken immediate release metf for 6 yrs and do Hiit 3 x per wk with no issue of exercise performance or gains i am an MD

[@arthdenton]

Dr. Sinclair suggests that you take Metformin on the days you DO NOT EXERCISE and you do NOT take it on the days you do exercise.

[@seguramx]

do you have a reference for that?

[@arthdenton]

@@seguramx Yes. Hopefully they allow URLs on this thread. kzbin.info/www/bejne/f3bdYoNqnpaDbdU At about the 23:30 mark.

[@DS-eu2ww]

Did Sinclair write his own prescription? How does he get it? He doesnt have sugar issues.

[@arthdenton]

@@DS-eu2ww You must be his personal physician. No? To know these things...

[@simplest2remember]

But Rhonda has said in a different podcast that it takes 36 hours for the effects of Metformin to subside, and that when you visit the gym (depending on your workout intensity), your body is repairing itself for a day (I forgot the exact quoted number) afterwards. This makes it a bit difficult to mix them. I have stopped now during weekdays, when I do HIIT, and have metformin at weekends only. I'm hoping Berberin does not have these side effects that Metformin displays

[@IvorMektin1701]

N=1 here. I took metformin for a couple of years, my neighbor gave it to me. It really does lower blood sugar. I started weights last year and could barely make any progress until I dropped metformin. Months later I added creatine and that made a huge difference.

[@djtz122]

I had the exact same result, but started taking it after lifting for 10+ years. My work capacity was cut in half. I lost all my strength after just 30 minutes.

[@mjpucher]

Metformin is better than getting early DT2 and going on Insulin. I felt complete shit on Metformin. Going low carb reset my insulin resistance and weight training and fasting healed my fatty liver. I lost 40 pounds and feel fantastic. I could never have done this on Metformin.

[@PaulSchneider-bp2ic]

@@mjpucher q48

[@PaulSchneider-bp2ic]

Q49

[@PaulSchneider-bp2ic]

@@djtz122 q50

[@PaulBeauchemin]

Over the past 5 years I’ve smashed my shoulder and broken my hip while exercising both required surgeries and a year to recover. Will take the metformin thanks

[@mjpucher]

Metformin wont heal stupidity

[@unlimited1652]

BPC 157 and TB 500

[@laluna5548]

I don’t think I have ever felt worse than taking Glucophage 500 mg for a week. Severe asthenia, myalgias, GIT issues, dizziness…UPDATE: Taking another form (Gluformin) seems to be working really well for my insulin resistance

[@wulfsorenson8859]

I got panic attacks on it!

[@ett2801]

I've been on Metformin (2000MG) daily for one year, and I have still been able to build muscle and gain strength. The only caveat is that the muscle building has been slower than before I was taking Metformin. Although, my muscles did grow.

[@aubreyj.tennant1123]

I appreciate Dr. R’s default organic proclivities. Especially if your under 60 considering the upside potential to downside risk dynamic. I’m 67 and an exerciser. I almost started Metformin a month ago and because I am not type 2 diabetic - I’m kinda glad I couldn’t get it here in Canada with a prescription. Dr. R’s honest perspective is cautionary but well presented I think.

[@yoso585]

Aubrey J. Tennant I think you’ve made the good choice. Missing from the conversation was quality of life. A most important factor, I would say. I would hope to be able to enjoy 22 minutes a day of some form of exercise rather than not be able to wipe my own ass, but tacking on the years, regardless.

[@encompasshealth9227]

The age related side effects is what interests me the most. David Sinclair seems to think that by increasing insulin sensitivity that the ATP production from mitochondria in cells becomes more efficient on Metformin. Mitochondria production efficiency is also linked to age-related diseases.

[@X-zk9vm]

And also linked to deficency in NIR light from the sun , and from indoor lifestyle

[@ngallure]

Thank you for your always informative clip on Metformin. Tell me has anyone responded to the study recently published in Jena, Germany and reprinted by the Cold Spring Harbor Lab "Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism"? The conclusions based on C elegans mainly are: Late life metformin treatment limits cell survival and shortens lifespan. Metformin exacerbates aging-associated mitochondrial dysfunction causing fatal ATP exhaustion. Old cells fail to upregulate glycolysis as a compensatory response to metformin. The dietary restriction (DR) mimetic response to metformin is abrogated in old animals. PKA and not AMPK pathway instigates the early life DR response to metformin. Stabilization of cellular ATP levels alleviates late life metformin toxicity in vitro and in vivo. Could you comment, please. Always interested in your input. Nancy McClure-Galli, M.D., MPH

[@silviaarmstrong5585]

Could you translate this in layman’s terms please?

[@hershlstern]

Thank you for posting this!! I wonder what David Sinclair or Bryan Johnson would say.

[@Weygandt]

I am a healthy 59 year old male who is not diabetic but am insulin resistant. I also see an age management Doctor who has been treating my Hypogonadism with Testosterone I.M. injections. I've been on Testosterone Replacement Therapy for 12 years and also work out on a regular basis. Working out with weights, I have strong muscle mass but always tend to hold on to 30 lbs around my body, most around my stomach. I am on a high protein diet and eat fibrous vegetables, omitting starchy carbs. When my doctor put me on Metformin it was a perfect fit for me. I lost 33 lbs in 3 months ( and now kept it off using Metformin for the past 3 years)...... I am around 9% body fat and very defined. It was the Metformin that worked for me along with diet and exercise......I am a believer.

[@moestietabarnak]

tried water fasting ? look it up

[@Weygandt]

@@moestietabarnak I drink enough water. There are so many people that make the mistake that you suggest. Water does not effect insulin resistance, low testosterone, etc... You can drink a gallon of water a day and if you're insulin resistant and don't omit starches and sugar, you'll never lose weight.

[@moestietabarnak]

@@Weygandt hmm ? really, look up water FASTING. here a little starting point : kzbin.info/www/bejne/bZ-tmHt4l6qaqac

[@Weygandt]

@@moestietabarnak No, I'm good. I'll follow my Doctors suggestions. Thank you for the link though.

[@apokist]

@@Weygandt What was metformin's effect on your muscle mass and exercise performance? Gereat that you lost weight and experienced other benefits

[@bradbo3]

Im 50 yrs old and Im type 2 for 9-10 years now...and on metformin. But 2 years ago I got serious and really hit the gym and watch my diet extremely close. Lost all the weight and KEPT it off and my A1C is 5.7.....daily glucose readings are normal and my Dr said Im no longer type 2 but wants me to keep taking it. I think Im better off without it....cant imagine how much better I could be physically without the metformin holding me back.

[@chris_2208]

Can anyone correct me on this? As I understand metformin only blunts the muscle hypertrophy and the cardio-respiratory fitness effects of exercise. The other exercise health benefits, like increase in telomere length or decrease in body fat percentage are not blunted by metformin. Thanks in advance!

[@tonikhoury785]

Wow nobody corrected you in 2 years. But yes, that what i understood as well.

[@afraimgershenzon8014]

Smart lady - but completely of the track. Starts with citing huge study of more than 70000 people increasing their life span by those taking netformin. Than she looses the point and starts to discuss the reduction in cardio capacity of those taking metformin. Clearly the training capacity of glucose reduction takers will be reduced. What's the big surprise...The issue was increasing the life span for type 2 diabetics-that is a very well established fact. By confusing the different aspects of metformin consumption the lecturer does a disservice to the audience. I am a MD with no diabetes at all and small iverweight. By taking 850mg daily lost 5 kg with no extra training and usual calory intake in 3 months. Feel great and more energetic.

[@RamilMagyerramov]

Thank you for this clip. Was just considering taking metformin.

[@robertdeskoski9783]

Because that's all they're doing. Or they're doing long-distance exercise which raises inflammation markers.

[@Gazz106]

At 5:48 Rhonda refers to an old study done in 2014 where rats with T2D were given the following doses 30mg per body weight, 100mg per body weight, and 300mg per body weight. I weigh 60kg. So if I were to take any of those doses I would be taking either 1800mg, 6000mg or 18,000mg. These are huge doses - I'm currently taking 425mg and am not diabetic. I feel fine and have not noticed any decrease in my physical performance. I have no plans on increasing the dose. But the question remains: If Metformin reduces one's chances of getting cancer by 31% (see FoundMyFitness Topic - Cancer) isn't this reason enough to take it???

[@r.guerreiro140]

Thanks a lot You cleared the issue Now it makes sense the discrepancy between the half life and the extension of the effect mentioned About myself, I would like to have a shut on/off button for both mTOR an AMPK, and metmorfin combined with TRF seems to be the answer

[@Alwaystrollingbro]

Its a huge misconception to think that rat and human dosages have a linear correlation. They don’t.

[@simplest2remember]

Has anyone seen anything that relates Berberin to reduced exercise benefits, since it's main mechanism is reducing and stabilising glucose level in the same way as Metformin. I have now stopped Metformin after listening to one or two of Rhonda's podcasts about exercise and Metformin not being synergistic.

[@faisal-ca]

I have recently started Berberine. I am non diabetic so there is no change in my glucose levels even after eating 500 mg x 3 per day. My digestion has got improved since Berberine helps with leaky gut problems. I felt more energy when I started taking it and now that it has become a norm so I don't fee the difference anymore.

[@laartwork]

Her suggestion is to just excercise. That is true... but much harder for most than she is assuming.

[@jmc379]

We need to take into account the effects of low IGF-1 levels in longevity through lowering MTOR. If Metformin can indirectly reduce IGF-`1 to less than 145mg /dl through suppression of MTOR, then the reduction of all-cause mortality from lower IGF-1 via suppression of MTOR in older persons may play in longevity - Perhaps a more important one. But has anyone looked into sarcopenia induced by Metformin as we age?

[@LS-fd6tl]

So with lowered IGF-1 muscle hypertrophy would be limited/altered? Would it be possible to perhaps avoid metformin around the training window so that igf-1 is largely unaffected there?

[@agrases]

The interesting question (or answer for that matter) isn't "Should healthy people take metformin?". What I would like to know is "Are healthy people getting any NET benefit from taking metformin, compared to those who do not take it?"

[@simplest2remember]

Healthy people who regularly workout?

[@agrases]

@@simplest2remember Yes, that's my question.

[@chewie94116]

Very informative! You answer a lot of questions about metformin use in healthy adults. You answer some questions which I have not even thought of yet.

[@SawmillerSmith]

I'm 71 and take no drugs and I would say I'm healthier than those who do I might die sooner though. Only time will tell. But in the mean time atlest I'm able to get around better than those on drugs. They need a study on people like me versus those on drugs.

[@IvorMektin1701]

Metformin is pretty innocuous but it does slow down gains if you're lifting weights. Some people get diarrhea from it. Never effected me.

[@SawmillerSmith]

@@IvorMektin1701 I lifted weight when I was in my 60s and I did notice everyone my age except for me had lost a lot of muscle mass. I think it was because they took drugs.

[@IvorMektin1701]

@@SawmillerSmith Yep! I just turned 51 so I wanted to get ahead of the curve. Are you taking creatine? It really helped me.

[@SawmillerSmith]

@@IvorMektin1701 yes I took creatine along with other things. I think lifting weights for 4 years straight till I was 64 has keep me healthy. I've been thinking of lifting again,just haven't done it yet.

[@IvorMektin1701]

@@SawmillerSmith Thanks!

[@samueldiaz7105]

Why athletes don’t live longer if exercise is ati-aging?

[@kurakuson]

Excellent question.

[@maki6867]

they do, it depends on the sport, for instance tour de france cyclists live longer, bodybuilders live less

[@maki6867]

this is because cardiovascular improvements, cardiovascular disease is the biggest killer

[@freedomdividendnews5042]

over exercising kills you

[@davidralphs4]

@@maki6867 Rich Piana lived to the ripe old age of 46.

[@moestietabarnak]

Since I've been diagnosed with T2D recently, I binge watch many video on all related matters.. from What I can gather (not a medical person in any way, but listening to Dr. Lustig and Dr. Fung and other) Metformin suppression glucose simply simulate the effect of fasting and low carb diet. It make more sense ... And since fasting is in our millions years adaptive evolution, We get the benefit without the risks associated with these drugs. and cheaper than free !( less food to buy heh !) I'll tend toward that more natural process. thank you + other benefit, our metabolism regain regulation without drugs. Why keep paying big pharma ?

[@redberries8039]

Interested in berberine. More easily available in the UK.

[@jamesf7933]

Berberine is widely available in the US also.

[@MrClimateCriminal]

berberine has some problems. check out this scientific study review: kzbin.info/www/bejne/m6uWc2eqi9qXnrc

[@zzzide]

Go to eastern europe countries and you'll find Metformin for 2€.

[@hoffmancapote]

Thanks Rhonda for an interesting video. I actually bought some Metformin 19 months ago, and after I had bought it I never even took one tablet because of some of the data you have referred to. I have for years participated in around 400 minutes of moderate active exercise for the last 30 years so guess metformin would not have many positive benefits for me but maybe the opposite

[@keithgilmour3361]

Becareful as prolonged use of metformin can cause lactic acid build up which can lead to acid acidosis, which can be serious with damaging symptoms.

[@davidderidder2667]

Hi Rhonda, can you please do an update on Methformin. I really want to start taking something to increase lifespan. What is the latest knowledge on this front?

[@josepho5055]

FWIW.........To David de Ridder if you would like to have a good back ground on metformin and the _"Latest information"_ review work by master of metformin Nir Barzilai MD.

[@moestietabarnak]

@@josepho5055 or for a more natural approach, checkout fasting/low carb with DR Fung, Lusting and others...

[@theantiqueactionfigure]

I have been sick with Myalgic Encephalitis for 17 years now. Exercise is not an option for those of us with this disabling disease. I have just recently added metformin to my treatment routine. The keto diet was very effective in helping me lose the 75 pounds I gained when I got sick. Most of that caused by the exercise intolerance which is a symptom of ME. Even on a very strict keto way of eating by blood glucose is rarely below 100. It was much higher when I weighed 75 pounds more, along with my total cholesterol and triglycerides. Only time will tell if metformin will replace the 30 miles a week I ran and the 30 one arm push ups in my routine before I got sick.

[@JustMe-hc2et]

How is it going? Any updates?

[@Chandrika-22]

Hi! Please answer here. Did it help you at all? Really need to know.

[@theantiqueactionfigure]

Metformin did nothing for me other than the exercise I got running to the bathroom. I feel my diet has done more than any single thing. #properhumandiet

[@theantiqueactionfigure]

@@Chandrika-22 please just ask about anything else.

[@Chandrika-22]

@@theantiqueactionfigure Thanks for your reply! I checked it out thoroughly online and I realize it would definitely not be a good option for myself. Glad diet is helping you. It seems the only thing that makes any actual improvement I've found. 💜

[@dennisfink2619]

We need some professionals like Rhonda to review the research on the 20 to 40 fold difference in lifespan of the Queen Honeybee compared to the worker honeybee that is attributed to being feed royal jelly for slightly longer. Dr. Nessa Carey discusses this as an epigenetic effect in a four year old You Tube lecture on epigenetics!

[@JerryDougherty]

Always excellent analysis of a rather complex topic. Thank you for all your amazing work 🙏

[@markusantonious8192]

No discussion of berberine, i.e. a natural supplement that largely mimics the good (blood sugar and anti-aging) effects of metformin...but without the side effects!?

[@simplest2remember]

I'm very much on the same boat with trying to hunt this info down. Unfortunately, there is very little research (and no reward for doing any I suspect) on Berberin.

[@Scottlp2]

David Edwards there was a recent podcast by Peter Attia, MD (another person worth listening to) that addressed your question.

[@simplest2remember]

@@Scottlp2 Cheers Scott - very interesting - seems that Met is generally better for controlling glucose, but Berberine can be brilliant for a small number of people with high LDL problems.

[@Scottlp2]

David Edwards the important thing to know about berberine is that is messes with “p450” ie your liver’s detoxification enzymes so it effects metabolism of many drugs and a number of supplements.

[@WahlVids]

What are your thoughts on Metformin effectiveness on cancer inhibition for prevention? There's studies out there on how Optineurin down regulation is possible through taking Metformin supplements thus preventing or reducing some types of cancer.

[@tomjones2348]

Dr. Patrick really digs into the data to uncover important information.

[@engineerepixlele2845]

I fail to see how Metformin + Exercise is worse than Exercise if you are doing Exercise not caring about how much muscle you get but just for general health

[@ironmaidenfitness654]

Would love to know if berberine has a similar effect while exercising

[@AlteroCoach]

I was always against metformin as I'd like to keep my mitochondria healthy and working 100%. I believe that the way it helps people with diabetes is inhibiting energy production in mitochondria and making body to relly more on glycolysis, so it helps to better utilize glucose and make blood glucose levels lower. And it's not solution to a problem but a temporary fix. However in the long run in can help to live longer as overall inflammation levels would go down. But In healthy individuals with a proper nutritious diet I don't see any benefits of metformin. And as cardio exercises activate AMPK I don't think to activate AMPK even more with metformin is a good idea. The dose makes the poison.

[@LTPottenger]

Slow mitochondria is a bigger source of disease such as cancer than high blood sugar. If your blood sugar is high stop eating carbs, so simple. Fasting also increases health for both diabetic and nondiabetic people.

[@AlteroCoach]

@@LTPottenger That's right! And yes, fasting is the way.

[@bill9989]

But that large meta-analysis that she references here is incredibly persuasive. Metformin "reduces all cause mortality." So something very beneficial is happening. It seems that drawing contrary conclusions from very specific studies may be "missing the forrest for the trees." In other words, to achieve the "all cause mortality" result, Metformin probably has many benefits, the specifics of which are not yet known. So we've found some negative things. But they may be several things in a big stew that overall may be very beneficial.

[@selinaogorman8380]

I been on metformin for 3 months it’s for hyperglycemia most likely prediabetes my sugar was 3 months ago 330 yesterday it came back to being a normal blood sugar of 93 this is the best reading I have by far my diet has changed to and losing weight as well honestly I feel at my best in a long time so am on 500mg 2 times I take metformin so far decreased appetite which is great so I don’t have to eat a lot now sticking to protein like lean beef natural peanut butter drinking water no side effects with this everyone will experience there medicine differently am glad I have positive results with metformin.

[@nuthanmaharaj6160]

Thank, you have shared critical information and have clarified many issues regarding weight loss.

[@martinnichols45]

Always seeking for a magic pill..... Eat low glycemic , do no overeat , exercise ( resistance and cardio) , manage your stress level and enjoy life ! IF , YOUR BLOODWORK INDICATES THAT YOU MIGHT NEED IT , THEN LISTEN TO YOUR DOCTOR ...

[@queenbee7074]

Umm HELLO how can a healthy person even get a prescription for Metformin??? Please address this issue first ! Its all well and good to talk about it but just a reminder most of us arent doctors and cannot help ourselves to this medication

[@smeyer6960]

Yes, AgelessRx. You have to find an anti-aging focused practice. The one I mentioned is online, check if it’s okay in your state, but short answer yes!

[@dzlart]

Came here to say this!

[@the3cl3ctic]

She sounds incredibly trustworthy!

[@pelonete5000]

I train once a week (the right way to do it, Mentzer and Dorian Yates way) HIT fashion on very advanced resistance machines I have, and do fast walking the rest of the days of the week. I 'm planning to take Metformin 3 days a week (which are the ones I have a high carb diet) in between my HIT workouts, let's see how it goes.

[@Lex_Fur]

can u give an update on how your method works?

[@pelonete5000]

No noticeable difference, for good or bad, Lex

[@tahoon2009]

Very important questions answered, thanks for such informative talk

[@spoudaois]

I a nondiabetic take 2 gms per day but it took time to get there.

[@brentmcculloch]

Berberine is often compared to metformin as a natural substitute, and some studies have show it's equally effective. I'm curious if berberine has these same non-synergystic effects with exercise as metformin does.

[@loganferti278]

It doesn't

[@brentmcculloch]

@@loganferti278 any citation?

[@loganferti278]

@@brentmcculloch In research published by the University of Maryland Medical Center, people who took berberine for eight weeks had better heart function and were better able to exercise than those who took a placebo

[@Jddjdurjf]

i read that Berberine has a very low absorption and may be quite useless because of that

[@AL_THOMAS_777]

@@Jddjdurjf Then simply take it together with b i o p e r i n e - up to 2000 % improved intake !

[@jk3266]

Madam, I don't like cardio exercises(trademill,running, ellipticals).I do lot of bodyweight squats,pushups, weight-training,Yog,basic pilates. My query is : do the exercises I am doing give me increase in glucose,insulin sensitivity ?at present,I don't have diabetes, hypersensitivity etc.i am 63years,male,live in India.

[@Subdcl20]

I have a hunch that metformin combined with SAD is what causes the negative exercise results. Perhaps too much stress put open the systems. It’s like consuming fat: Works well when avoiding sugar and eating lots of leafy greens. A person’s diet should be a factor in a controlled study in future trials. In 5 years, excluding diet as a major factor in research might be no brainer. The reason it isn’t now???

[@neslisultan]

My sentiments exactly! Gone are the days when we can ignore the effects of our diets on our health. It should be the first thing considered before all else.

[@higherresolution4490]

Many thanks for posting this video. In the past 2 weeks, I have been considering taking metformin. I dismissed it's use a long time ago because of the negative side effects. However, a friend of mine, at age 64, has now been using Metformin for 3 months and getting good results. From this talk with Rhonda Patrick, and the fact that I exercise as much as I do, including heavy weight training, there's no way I'm going to take metformin. I worked in a mitochondrial lab at an UC campus, and the idea of inhibiting the efficacy of Complex 1 in the Electron Transport Chain is unacceptable. The only possible benefit of this effect might be that there is less ROS leak from Complex 1, which is the enzyme complex that produces the most free radicals in the matrix of the mitochondria.

[@robertstancliffsr9575]

Remember, negative side effects are often overstated. even if metformin might cause something bad 1% of the time, many people simply say, metformin cause bad things..........happens all the time, making it very hard to know the truth..

[@dannyiskandar]

so basically if you exercise is better NOT to take metformin ... You are taking the risk the eliminate the benefit of exercise by taking Metformin. So why David Sinclair is taking it?

[@faisal-ca]

I have recently started Berberine. I am non diabetic so there is no change in my glucose levels even after eating 500 mg x 3 per day. My digestion has got improved since Berberine helps with leaky gut problems. I felt more energy when I started taking it and now that it has become a norm so I don't fee the difference anymore.

[@rauljhon9757]

Berberine explain uses

[@crowdancer5]

I thank you!!! I was seriously considering asking my dr for metformin......I am borderline diabetic and just dont want to go there......but want to coninue this life in a more healthy manner.......You have helped me to decide not to ask for it!!! AND, I have watched yu videos AND...listened to what you present s I trust where ou lead......just need to understand and know what is best or this body!!!

[@michaelwayne1977]

Find it hard to believe that metformin would block benefits of exercise.

[@jameshowlett4438]

what about the study that actually REVERSED aging with metformin, GH, and another diabetic drug?

[@gamblinguru33]

Metformin was only included to mitigate the disruption in insulin sensitivity due to hGH. It's really the the hGH and the DHEA that is reversing signs of epigenetic aging.

[@chris_2208]

Can anyone correct me on this? As I understand metformin only blunts the muscle hypertrophy and the cardio-respiratory fitness effects of exercise. The other exercise health benefits, like increase in telomere length or decrease in body fat percentage are not blunted by metformin. Thanks in advance!

[@cgillit]

@@chris_2208 Yep. Metformin targets multiple signaling pathways. This discussion seems to only focus on one. www.cell.com/cell-metabolism/pdf/S1550-4131(16)30229-7.pdf

[@sleepsmartsmashstress740]

Metformin likely works through improving the diversity of gut microbiome mostly so if you manage diet, stay active and socialize you dont need the pill. All pills have side effects

[@geraldfriend256]

Rapomyacin? Would that be the other diabetes drug?

[@jatai07]

An endless question!

[@Bogdanbmm]

Cool, if I remember correctly Mr. Sinclair takes Merformin and exercises but only takes Mteformin in the off-days when not exercising. Any feedback ? Thank you

[@5dollarshake263]

I strength train mon/tues and thurs/fri , and I've recently added metformin on sat/sun to attempt to make me very insulin sensitive for when I push carbs on training days , I just began this experiment last weekend but I will soon see if my performance takes a turn for the worse or continues on its trend upwards

[@redberries8039]

I take berberine 5 days a week on a 4hr eating window [after the meal] and stay off it on a training day and the following day [while I re-feed]. Feels right.

[@redberries8039]

...i understand the half-life of berberine is quite short [a few hours] so perhaps training 24-48 hrs after might be ok ???

[@redberries8039]

umm she covers this ...busted

[@cwstars]

Berberine on days I dont lift feels right

[@mr.greengold8236]

How about supplementing with Beriberine?

[@mrm8818]

Hasn't been studied as much but it acts on the same pathway acting on AMPT (think it's that spelling)

[@victordasilva5255]

Good stuff dr Rhonda. I was taking Berberine with a fasting glucose of 95. I’m going to stop.

[@Despairnot]

Hi there, what do you mean exercise? What sort of exercise? How long?thank you.

[@roblovegreen]

Please tell me one drug that is more effective at healing and preventing disease, without negative side effects , than proper nutrition, exercise, and sunlight.

[@1Timatin]

Tanks for such particular topic. Find out answer for my direct concern about taking metformin during exercise circle.

[@x1magalhaes]

I exercise every other day and was planning to take metformin after David Sinclair said he took it in the days he didn't exercise. I'm still searching about it. Thank you for talking about these randomized trials, Dr. Rhonda Patrick.

[@lindamcneil711]

Would the effect be synergistic or is there a point of diminishing returns. It sounds like you are finding your answer. What interesting questions. Great topic here.

[@samuelbrainsample]

I really need to understand the implications of berberine, metformin, and antioxidants and their role in blunting hormesis in strength & aerobic, HIIT exercise. Is there ever a good time to take any of these things and not damage the building/adaptive aspects of various forms of exercise?

[@wulfsorenson8859]

Presumably don’t take them on training days or at least take them several hours before or after training?

[@erwinrogers9470]

Great information 🔥

[@5dollarshake263]

I strength train mon/tues and thurs/fri , and I've recently added metformin on sat/sun to attempt to make me very insulin sensitive for when I push carbs on training days , I just began this experiment last weekend but I will soon see if my performance takes a turn for the worse or continues on its trend upwards

[@andrewj4426]

Let us know how it goes.

[@cipriantodoran1674]

Update?

[@coolbyfar]

I think he OD’d off the metformin bean

[@Lex_Fur]

yea plz update

[@kmanil8689]

I am from Sri Lanka my husband takes Metformin since last year he is not a diabetic or pre diabetic patient. He says it wouldn't harm according to some doctor's and scientist's publication. His father was a diebetic patient so he thinks he wouldn't get diabetic in future if he takes 500mg tablet in daily.

[@ChrisB.BellM.D.-no2cv]

I’ve been studying Metformin for years. MD and nutritionist. My thoughts for those with good nutrition and frequent exercise. Start Metformin the day before vacation, stop last day of vacation. I have not found studies for this. Your thoughts???

[@ajl8615]

Hi, please turn on the English subtitle for us, thanks.

[@bmohre4784]

All these discussions about metformin, but no one talks about dosage. How much are the subjects taking? How often?

[@BizzyIzzy87]

What about if you are on TRT and taken metformin

[@StormZaara]

It keeps you young

[@birage9885]

Why not talk about methylene blue instead of metformin for mitochondrial energy?

[@serafinoanselmo8329]

What idf taking metformin with berberine will have a significant result?

[@okironin8180]

Can u post the link to the study?

[@acegolfman3203]

Metformin has been around for 100yrs. Has a safe profile

[@Splassshhh1234]

love you, Rhonda

[@opaloakley]

My igf-1 is too high. I've read that Metformin lowers igf-1. Would exercise lower igf-1 as well?

[@geraldfriend256]

Yes,and reduce carbs.Also take protein with fat .Reducing insulin reduces igf1.

[@margrose5]

I wonder if berberine would have the same effect on exercise benefits.

[@NatashaClarke-y2e]

Thanks. Did the healthy people taking metformin first do a liver and renal test first?

[@olasaltasm]

Great video!

[@davidjones4063]

I found 2 X 500MG MF a day killed my HIIT workouts and recovery. A real combo killer is a Statin and MF. What energy pathway is not being suppressed.

[@garnetrose6162]

Only take metformin on days you don’t work out