Sickle Cell Disease “Part 1” Intro

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[@MedicosisPerfectionalis]

💊🦠 Antibiotics Course: www.medicosisperfectionalis.com/ 🧠 Autonomic Pharmacology Course: www.medicosisperfectionalis.com/

[@abdulrahamangamal1966]

فرحت جداً لما لقيت فيديوهاتك اللي فعلا انقذتني وفرحت اكتر لما طلعت مصريي زيي حقيقي ببقى فخور جداً وانا بشير الفيديوهات بتاعتك لصحابي واقولهم انك مصري ربنا ينفع بيك ويكرمك دائماً وابداً ❤❤

[@MedicosisPerfectionalis]

Thank you 🙏

[@nouranfarag1228]

Egyptian teachers can never fail to make me understand anything no matter how complicated it was!! Ur vids are gold

[@MedicosisPerfectionalis]

Thank you so much 😊 I appreciate you! Can you please help me by sharing?

[@nouranfarag1228]

@@MedicosisPerfectionalis Sure, already did! Told all my friends about ur vids, we 've been lost in hematology for a while tbh

[@MedicosisPerfectionalis]

Thank you so much 😊

[@RafiullahZadran]

Such a talented teacher

[@moamaljameel4411]

Is he really Egyptian?

[@nouraayed]

omg I’m soo proud!! I learned from a lot of Egyptian professors you guys are blessings greetings from KSA 🇸🇦

[@MedicosisPerfectionalis]

Thank you so much 😊

[@suzyguirguis3709]

I guessed the meaning of the smiley face right, Egyptians are very good teachers :D

[@MedicosisPerfectionalis]

Thanks a ton 😊😊

[@mmfoudeh6360]

Egyptians are really a funny people , and that an evidence

[@MedicosisPerfectionalis]

Thanks 🙏

[@sma11111]

I am very proud to have an international medical channel of this level run by a Egyptian person. Love from Egypt ❤

[@MedicosisPerfectionalis]

Thank you!

[@nancywael3673]

I was suffering but now hematology became the most interesting branch of internal medicine I have ever study thank you 😊❤❤❤❤❤ I am an Egyptian student

[@arwaashraf7199]

I am Egyptian too , & Big fan of your videos and the way you teach 😍❤ you're helping me a lot in my exams Now I'm also so proud of you ❤👏 keep going on ✌

[@MedicosisPerfectionalis]

🩸 Hematology Playlist: kzbin.info/aero/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq

[@mera6039]

Thank you so much ! The hematology series helped me a lot! Greetings from Syria 🇸🇾

[@MedicosisPerfectionalis]

I appreciate you!

[@daniaadnan8573]

I'm so proud knwoing you're egyptian! I can not thank you enough for your videos!

[@terutun8827]

Thank you for this clear explanation and am really enjoy it. I find myself fall in love with hematology. Thank you

[@MedicosisPerfectionalis]

Awesome 👏 I am so happy to hear that. Please help me by sharing :)

[@karamellboo690]

I'm from egypt too ,so proud of you 😍 Keep moving forward 💪 Thanx for ur videos 👍

[@MedicosisPerfectionalis]

Thank you so much 😊

[@mennak113]

Soo proud that someone like you is Egyptian🇾🇪 أكثر من رائع 👑

[@DR_Aabdelsalam]

A new subscriber from Egypt♥️ proud of ya

[@MedicosisPerfectionalis]

Thanks a ton 👋

[@abdullahkaram9371]

أنا بسمع فيديوهاتك بقالى 3 سنين فرحت أوى لما عرفت انك مصرى. إبن بلدى الفخر

[@MedicosisPerfectionalis]

Thank you 🙏

[@BillieB.]

Unfortunately I have SCD😞 I come to videos like this for comfort when I'm in pain. I know it seems weird but it helps me relax 😴. It also doesn't help I'm a Colorado native, because of our higher elevation. Also please keep in mind, I can only watch videos and such with lower pain levels because unfortunately sickle cell can be debilitating with high pain levels.

[@mynikeable2006]

So sorry about this. I have two kids with SCD. I can only imagine your pains.

[@BillieB.]

@@mynikeable2006 Much love 🙏❤️

[@doaael-kala2715]

i'm also from Egypt your teaching manner is very simple and valuable go on you're a genius

[@MedicosisPerfectionalis]

Happy to hear from another Egyptian here on KZbin...Thank you so much! I truly appreciate it...Please consider sharing my videos with others! Thanks a million!

[@ali-bk9yo]

@@MedicosisPerfectionalis im egyptian too

[@MedicosisPerfectionalis]

👋

[@billrowe3350]

My amazing wife has sickle cell disease doing my homework so I can advocate for her. Thanks for making the videos!!!

[@MedicosisPerfectionalis]

Thank you! Please say Hi to her!

[@billrowe3350]

@@MedicosisPerfectionalis Thank you so much for the shout out to her. She said hello. Thanks again for your time you’ve put into this.

[@MedicosisPerfectionalis]

I am honored! Thank you 😊

[@BillieB.]

@@billrowe3350 You must be and amazing husband to take the extra step to educate yourself about single cell. I also have SS unfortunately, and I wouldn't know what to do if it wasn't for people who care about me like my mother! This made my day, best of luck to both of you, and I hope your wife can stay healthy as possible 🙏☺️

[@mahaleila1429]

I stopped the video to comment So Proud of you , Greeting from an Egyptian student loved your lecturers

[@MedicosisPerfectionalis]

Thank you!

[@sophiakhan3997]

Thank you so much for your videos. Would you say sickle cell is normocytic anemia and thalassemia micoryctic? Do you see the same thing in both on them on the FBC and blood film?

[@sayeddahab930]

You are the best one I had ever listening ...I'm Egyptian too

[@MedicosisPerfectionalis]

Thanks a ton, brother!

[@hudaibrahem1338]

Our river nile's brothers 💙 iam from sudan Great video as always , thank you for your efforts .

[@omaryousef4907]

انت مصري يا جدع؟ بعد ما عرفت انك مصري تعمقت عندي مقولة مصر ام الدنيا والله حيا الله اهلنا بمصر والله يهونها على اهلنا بغزة يارب❤️❤️

[@saraabdo2333]

والله انصدمت بسم الله ماشاء الله ❤❤❤❤ يارب تكون بتعرف تقرا عربي ❤❤❤❤ بجد انت عبقري you are genius,so proud of you, you are Egyptian ❤❤

[@mayadaragab4334]

I'm so proud of you 🇪🇬❤ keep working ❤❤

[@omaraw740]

so proud that an egyptian is making such quality medical videos ! im egyptian too !

[@MedicosisPerfectionalis]

Thank you so much, bro

[@omaraw740]

@@MedicosisPerfectionalis anytime! thanks to you i will hopefully ace my upcoming hematology final !

[@khamikos1]

you are a great teacher.thanks from Greece

[@MedicosisPerfectionalis]

Thanks brother for your comment...I truly appreciate it! Good luck!

[@Sarah-hc9ob]

مصر ام ام ام ام ام ام ام ام الدنيا دايم تجيب لنا دكاترة زي العسل 😭❤️❤️❤️❤️❤️❤️❤️

[@MedicosisPerfectionalis]

😃😊😊😊

[@catrina5808]

Are you Egyptian ? Wow! I like my Egyptian teachers, they are the most creative teachers and you are one of them 🤣❤️ Thanks for your helping. I like this series of videos because I am a laboratory science student and I’m interesting in haematology. You make this science very simple and understandable.

[@MedicosisPerfectionalis]

Thank you 🙏

[@meme-lm2zd]

thanx alot doctor n by the way..i'm enjoying watching ur lovely vidios from ur home country😀🙌

[@MedicosisPerfectionalis]

So happy to have you! I wish you the best of luck. Thank you so much for your kind words.

[@bismakamal3389]

You're AMAAZINGGGG😭❤👏👏👏 ThankYouSoMuch

[@MedicosisPerfectionalis]

My pleasure 😇

[@asmaaramadan8176]

طب والله كنت حاسه انك مصرى من هزارك الدم بيحن والله😂♥️♥️

[@MedicosisPerfectionalis]

Thank you 😊

[@drowsycemar6791]

I have sickle cell SS and this video is one of the best one out of explaining what it is and what it does

[@MedicosisPerfectionalis]

Thanks 🙏 Best of luck!

[@foreverbangin]

I do too

[@drowsycemar6791]

三ForeverBangin you have SS?

[@foreverbangin]

DrowsyCemar yeahh I got SS

[@drowsycemar6791]

三ForeverBangin oh how old are you I’m 14

[@abdullahitilde7358]

I like your video. You are a good teacher

[@shaikhamed3625]

So proud of you Keep working 💕🙏🏻

[@MedicosisPerfectionalis]

Thank you so much 😊

[@yarasobhey5844]

Iam Egyption also and you videos are addiction for me .. thank you very much 😁

[@MedicosisPerfectionalis]

My pleasure 😇😊😊😊😊

[@khloudsalah6140]

i am the most proud one of you Dr here as i am an egyptian too😀😀

[@MedicosisPerfectionalis]

Thank you 😊

[@raphaela3544]

Thank you for your videos! God bless. 😊😊

[@MedicosisPerfectionalis]

You too...Thanks a lot!

[@user-fc9ki2ql4j]

Now l'm a big fan of you specially after knowing you are egyptian like me... Keep going👏❤️

[@MedicosisPerfectionalis]

Thank you 🙏

[@Emanaia]

طلعت قرايبنا يا زلمة والله انك كفو❤😂 ثانكيو

[@Menna-xp2ov]

I'm Egyptian too :) Your videos are great .. I'm so proud of you

[@MedicosisPerfectionalis]

Thank you so much 😊

[@farihatilat7866]

I love u & depend on u more than any teacher of my life .......❤️❤️

[@MedicosisPerfectionalis]

Thank you so much for your continuous support!

[@fahmiramzy5716]

wow! ! Very easy way to understand a very tough topic

[@MedicosisPerfectionalis]

Thank you so much for that...It means the world to me!

[@fawazalanazi3793]

why im surprised that you are from Egypt your English is so good and simple thanks

[@MedicosisPerfectionalis]

Thank you, brother!

[@Geoblek1]

Nice videos but, possession of hemoglobin SS is sickle cell anemia. SC,Sthal,SE,SF is sickle cell disease and AS is trait, do rectify with any African medbooks, thank you, I really enjoy your videos

[@fatmaabdel-hamid8657]

i am egyptian too :D thanx for ur videos so proud of you

[@MedicosisPerfectionalis]

Thanks, dear 😊

[@Rene-uz3eb]

While in hospital, giving 50% oxygen unsickled reversible sickled cells, but it did not reduce pain, in a study. I think though that's only because it takes a while to decide and get to a hospital and receive treatment. If you tried to maximize oxygenation (breathing etc) at onset of crisis, probably most sickled cells could still be reversed. Acidosis leads to right shift of the bohr curve. Two ways to prevent it, one right and one wrong: decrease in co2 eg by hyperventilating reduces acidity, BUT (god knows why*) less co2 directly reduces cerebral blood flow through vasoconstriction, which can lead to strokes or seizures in already compromised sickle cell blood flow. So the other way to reduce acidity is by increasing bicarbonate, which is something that can be done by eating baking soda and has already been shown to be beneficial in ckd (ckd is common in SC). I say baking soda should also help in crisis onset. Not only does it make oxygen stay in HbS by left shift of release curve by lowering ph, it also allows more CO2 to be in the blood, which increases brain blood flow. *actually the weirdest thing this is: there is this big hole in the literature that on the one side acknowledges that co2 directly regulates amount of brain blood flow 'through some unknown mechanism'. So I figured it must mean the brain actually needs co2 somehow. What I find is animals actually fixate co2, especially the brain, ie co2 is turned into some other carbon molecules. Nobody talks about that at all since 1960 or so. Is this some sort of conspiracy??

[@sarahmassoud6578]

Egyptian too 😍💕 May God bless u the best teacher.

[@newness9486]

Thanks so much for this video 🙏

[@MedicosisPerfectionalis]

You’re very welcome!

[@phantom-quran-relaxation.1069]

Hats down for you my Egyptian brother ❤

[@franciscosantos3437]

Thanks for your video! Just wanted to do a small correction when you say that "Valine substitutes Glutamine", it should be "substitutes Glutamic Acid", on 6:24

[@ra.7735]

a mother of Hb S/ßTh and father of sickle cell trait, what is the chance to get affected child ?

[@nancywael3673]

so proud of u 😊❤

[@akthamadams7989]

I was wondering where you from. Egypt. اطيب ناس والله ياراجل

[@ImranKhan-wv5ly]

Thank you Basha........

[@MedicosisPerfectionalis]

My pleasure 😇

[@mohamedzidan9164]

So proud to know that you're egyptian❤️ God save you 🌼❤️

[@MedicosisPerfectionalis]

Thanks 🙏

[@chrisstemr7962]

Thank you sir 👍🙏,you are best.

[@MedicosisPerfectionalis]

Thank you 🙏

[@MsAqswdefr]

I am from Egypt and I am looking forward to communicate with you , also I am proud with your awesome videos

[@MedicosisPerfectionalis]

Thanks, brother! You can send me messages on my Facebook page.

[@srinivasaraosirasapalli5104]

i got the concept.thank you

[@MedicosisPerfectionalis]

My pleasure!

[@meryemlahbara9669]

I just found your channel .. I like it ..

[@MedicosisPerfectionalis]

Cool!

[@wandersuero7093]

Hey great video but I think that the graph is incorrect because if the sickle with no o2 that will make rbc more likely to shift to the left and increase their affinity for 02 thus avoiding the deoxyganted state

[@saraahmed1898]

I am Egyptian too I didn't expect that Proud of you ❤️

[@MedicosisPerfectionalis]

Thanks, dear :)

[@suzyguirguis3709]

same here

[@MedicosisPerfectionalis]

😊😊😊😊

[@wafaalotfi455]

Same here 😃✨💞

[@aya_Bou]

from Algeria .... thank youuuu sooo much

[@MedicosisPerfectionalis]

My pleasure 😇

[@user-kp8cr7uo5c]

Egypt is ur home country? really ? so becuse that u have a magic way to explain and delivering a hard ingormation in so easy way 🤩

[@emanalashmony3347]

You are Egyptian! What a pleasure! We are proud of you ..

[@nihalgaber3403]

from where in Egypt?? so proud to be from my homeland too

[@gogom4590]

Wow I am shocked that you are from Egypte😳😍

[@moonakhan1168]

It was Awesome

[@alaaahmed896]

الله معقول العسل ده محتوي مصري ❤️❤️

[@MedicosisPerfectionalis]

مصري وبابا مصري

[@khaledelmasry1961]

الله عليك يابن بلدي!!

[@MedicosisPerfectionalis]

😊😊

[@lanaalfares8350]

طلعت مصري 😊 شكرا الك على الفيديوهات الرائعة

[@MedicosisPerfectionalis]

😊

[@sarahk7639]

My lord! It's so shocking to me that u were Arab all along …woow wow love it ♥️♥️when u said Egyptian im like no wonder he has a great sense of humour

[@MedicosisPerfectionalis]

Thank you!

[@lewishamilton3668]

I was wondering from the beginning of the series what your nationality might be, I never thought you'd be form Egypt too because that's where I'm from :) Also just out of curiosity, is hematology your specialty or something else? or are you still not specialized? Thanks a lot for your videos they really help me!

[@MedicosisPerfectionalis]

Thanks, dear! Hematology is not my specialty, I just love it.

[@rehabhh5834]

Not your subspeciality..what if it is

[@DhanKevin]

I've been a subscriber since u started..please create video about hemostasis primary and secondary.. thanks :)

[@MedicosisPerfectionalis]

I am coming to that subject after anemia...Thanks for your comment and encouragement:)

[@Whateverrr70]

طلعت مصري؟ الله عليك يا فخر العرب😂❤❤❤ كلش شكرااا على كل شيييييي

[@MedicosisPerfectionalis]

Thank you 😊

[@samyan_saleem4252]

Thank u:)

[@hebamarwan7648]

Perfect👌👌

[@MedicosisPerfectionalis]

Thank you very much 😊

[@yousufbederyousuf2101]

Thank you very much! please can you tell us your references

[@MedicosisPerfectionalis]

Harrison’s, Davidson’s, Goldmann-Cecil, and Goljan

[@user-id7cm1xh2w]

You are the best. From egypt 💋❤️

[@MedicosisPerfectionalis]

Thank you!

[@manasikhassan945]

I'm sudanese so u r my brother😊 Egept is my scond country❤

[@MedicosisPerfectionalis]

Of course! Thank you so much 😊

[@r.y776]

New update, Sickle cell now considered to be at position 7 ( not sex ) on chromosome 11 😊

[@rayyashalata6229]

What is the name of the application youre using to draw these slides??

[@MedicosisPerfectionalis]

Please send me an email

[@yvonneneijhorst]

hellooo from Suriname...doctor is thalassemie the same as cikkelcel disease?

[@happysloth3208]

No they’re different diseases. Thalassemia causes reduced synthesis of alpha or beta hemoglobin. Sickle cell, is caused from a mutation in the gene that encodes for beta hemoglobin so they produce the wrong type of hemoglobin.

[@doctorv851]

How can v distinguish sickle cell and beta thalassaemia based on clinical features ?

[@MedicosisPerfectionalis]

The demographics are different! because part 1 of physical exam is an overview of the patient’s “look”.

[@user-ie5ic4mj5c]

Thalassemic face .. they have maxillary hyperplasia and frontal bossing ( prominent frontal bone) due to extramedullary expansion of the bone marrow and this is seen in thalassemic pt rather than sicklers .. in a pt with thalassemia you may find spleenomegaly but above 5 years you almost will never find spleen in sickle pt due to auto amputation and this is exclusively for sicklers .. also there is another clinical feature could differentiate between them

[@adamsharabi24]

You said that there is a glutamine in Position 6 when there is a Glutamatic acid (Glutamate), Just wanted to let you know

[@adamsharabi24]

Either way, a phenomenal video! Thank you!

[@QassamAlaa]

Nice video . i thought you are Indian american whatever your nationality is , you are the besttttt ever

[@MedicosisPerfectionalis]

Thanks a ton!

[@rehabhh5834]

You live in egypt or another country

[@janaayman1505]

انا كمان مصرية I'm so proud of being egyptian♥️🇪🇬

[@MedicosisPerfectionalis]

Thank you so much for watching!

[@ReethuVincy22444422]

AA as in? And Aa?

[@khowshickthijey1692]

what about the next part in sickle cell anemia?

[@MedicosisPerfectionalis]

It’s coming soon...I am in the midst of the process of preparing it :)

[@khowshickthijey1692]

Medicosis Perfectionalis oh thanks again 😊😊

[@MedicosisPerfectionalis]

Sickle Cell Disease “part 2” ; Pathophysiologykzbin.info/www/bejne/oJyyp6OBo5ani8k

[@Doctor____Z]

Woooooooow 😮😮😮😮😮😮you are amazing 🎉👏

[@MedicosisPerfectionalis]

Thank you!

[@primrosemadzinga7183]

Great video but the ads are too many

[@dr.zinaart5274]

I was doubt that you are Arabian especially Egyptian because u have soul of humor 😍💕

[@ebrahembenbadis590]

انت مصري ايه ولا احنا حبايبك من الجزائر يعني كم امل انو اتحصل على usmle

[@MedicosisPerfectionalis]

Good luck to you, bro!

[@yoyo-zq6yi]

Ur egyptian! Egypt must be so pround!

[@MedicosisPerfectionalis]

Thank you 🙏

[@maioosa1997]

lol i have been watching you for years and had No idea you were Egyptian ! , Great job tho !!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@jonc8845]

They can treat it with crisper

[@alimeran7442]

so Right shift i s a cause or consequence ?

[@MedicosisPerfectionalis]

I don’t understand

[@abhikhalder7351]

cause

[@jimayla7446]

I appreciate your videos but 25%, 50% etc are probabilities not frequencies. 2:36

[@kelakela8318]

Nice

[@MedicosisPerfectionalis]

Thanks 😊 Can you please help me by sharing?

[@kelakela8318]

That must have been my little girl that has commented, so sweet. Anyhow, I am so grateful for your videos, I definitely will share them. All the best! Thank you again.