Sickle Cell Disease “part 3”: Clinical Picture

[@MedicosisPerfectionalis]

💊🦠 Antibiotics Course: www.medicosisperfectionalis.com/ 🧠 Autonomic Pharmacology Course: www.medicosisperfectionalis.com/

[@sulyanekorine2375]

1- splenic sequestration 2- acute chest syndrome 3- Neisseria meningiditis 4- Neisseria 5- m/c is Salmonella 6- streptococcus pneumoniae 7- in SCD = HbS (m/c) 8- deterioration of pt's health status, bc of inf. , stress , ... which may leads to crisis if not treated appropriately.

[@saintswekuzed1563]

Well done ✅

[@vanshitasonkhle]

You’re like my guardian angel who saves me from this med school stress…. I’ll be forever grateful for you and your videos Thankyou so much for always helping me out

[@MedicosisPerfectionalis]

You’re very welcome, dear!

[@MedicosisPerfectionalis]

Dactylitis is vascular necrosis of metacarpals and metatarsals...On X-ray, you may see osteolytic lesions.

[@anizaabdiabdullahi478]

🙏🙏🙏 tnx dr very appreciated your wonderful explanation

[@shreyalothra2751]

Entero virus is the cause of hand foot and mouth disease

[@frosche1454]

What took me 3 lecture days and many nights to understand this concepts, you made it only in 1 and a half hour or so. If you were the one lecturing I would always be on time and never miss any of your class.

[@MedicosisPerfectionalis]

Thank you so much 😊 I am honored!

[@Attack441]

I have never seen a good demonstration videos as yours ! I dont even have to open hematology books after seeng this video .. thank you for tour effort , a future doctor from saudi arabia ❣️

[@MedicosisPerfectionalis]

My pleasure! Thanks a million:)

[@faig7183]

@@ThatsWhy- رافضي

[@ThatsWhy-]

@@faig7183 where are you from buddy?

[@aj-kv6ji]

Hope you made it through med school?

[@Attack441]

@@aj-kv6ji hi , im currently a urology resident PGY3 :) many thanks to the content creator

[@therealdreshady]

I love u! please come out with youre own program, like physeo, pathoma, first AID, lectures and questions, with question videos. You are the BEST, youre multisystemic, its what lacks in todays education. Professors have a chip on their shoulder, they should be helping students not let them fend off on their own. My medical school knowledge and integration has purely been because of your videos!

[@MedicosisPerfectionalis]

I appreciate you so much!

[@travelerdoctor9066]

1-stroke 2-chest problem 3-pneumococcus 4-E.coli 5-samonella 6-Neisseria 7-Hbs 8-chest +asplenia (need blood transport)

[@travelerdoctor9066]

Thanks for these nice video

[@sofiaahmed3872]

Thank you for answers

[@abdulrahman_imad]

I’m from Iraq You are the best Thank you very much for these videos 🇪🇬🇮🇶🇪🇬🇮🇶🇪🇬🇮🇶🇪🇬🇮🇶

[@MedicosisPerfectionalis]

My pleasure, bro

[@kiara198923]

I have sickle cell disease SS. I'm currently in a crisis which has been getting worse but they won't admit me into the hospital claiming they are at capacity due to C-19 patients. I get how severe C-19 is but so is sickle disease. I need an oral surgery which is 3 years in the making because I can't afford it. I've had 2 hip replacements due to Avascular Necrosis which has ruined my front teeth. It's so humiliating. I've postponed my graduation for medical billing and coding because I can't smile. If I made a GoFundMe for the surgery it probably won't get any support. Trying to manage a crisis at home is so hard.

[@onyiokoro864]

You're not alone dear, I have sickle cell disease too. I have major crisis every month and minor crisis every day. I repeated a class in medical school, because I was too sick to write my professional exams. I literally die and resurrect anytime I have to write any professional exams. I just want to let you know it's not the end of the world for you, you're meant for great things. Just see yourself as God's special creation, cos everything changed for me once I saw myself in that light. PS: I'm a doctor now😎 It'll be a pleasure to know you

[@rasha6597]

You're my favorite professor ever !! Thank you so much ❤️

[@MedicosisPerfectionalis]

Wow, thank you!

[@ayeshaarifhussain9848]

Hey..dr ayesha here form pakistan i use to watch your series its amazing keep it up best luck...

[@dr_chiropractor]

Best demonstration out there, thanks for the beautiful explanation doc, I need u to shed more light on the defects related to bone abnormalities, you talked about 2 of them in brief without a full description of their characteristics, I’ll be glad if you could reply to this message. Much thanks once again

[@MedicosisPerfectionalis]

Tell me more...What do you want to know?

[@sarahmina1442]

THANK YOU SO MUCH! you saved my hematology rotation

[@MedicosisPerfectionalis]

Awesomeness!

[@wafaamohamed8519]

Hello ! greetings from Egypt Thank you for your great explanation ur very excellent

[@MedicosisPerfectionalis]

Thanks 🙏 Can you please help me by sharing?

[@ummehafsa4096]

Too good sickle cell series🖤 From Bangladesh 🇧🇩

[@MedicosisPerfectionalis]

Thank you 🙏

[@sallas5534]

I am not confused that you are egyption Egyptions the best medical teachers

[@MedicosisPerfectionalis]

Thank you so much 😊

[@diptosusmay6179]

you've made the sickle videos molecular and complicated!

[@Rene-uz3eb]

12:23 um no autosplenectomy does not occur at 12 months of age for everybody. I just checked a study on it and half the scd patients did not have autosplenectomy, mean age 28 years. 15:17 g6pd only kicks in in vitamin D deficiency.

[@amirasaied5755]

hi,HRU? i am really enjoying ur series , i dont comment on all ur videos but i like them all as i dont have much expressions to tell but really u r amazing, as i am preparing for my MD pediatrics exam within 3 months , i am trying to go fast within ur videos. as regarding Hand,foot,mouth disease , i guess it's a viral illness due to non polio enteroviruses(coxsackie A v.) thank u

[@MedicosisPerfectionalis]

Correct answer...Thanks for your generous words and kind heart. Does HRU stand for “How are you?”😅

[@amirasaied5755]

Yes How are you, bas besor3a in Egypt😅

[@MedicosisPerfectionalis]

LOL! I thought it’s a medical term 😂

[@amirasaied5755]

😂😂😂😂

[@opgaming-tm4ow]

You explain things so nicely

[@vincentanniebero5343]

A 21 year old patient with pneumonia, rbc, hgb, hct- low, mcv -nml no sign of jaundice can we suspect sickle cell anemia as a cause....

[@niss2nice]

If the hemolyis is extravascular, what is the mechanism of hemoglobinuria in sickle cell disease?

[@tasnuvatahsin8032]

If the haemolysis is extravascular, can we find splenomegaly is sickle cell disease? Even though there is auto splenectomy!!

[@mennatarek6]

Thank you for this very thorough series. Very proud that a person from my country is doing a great job. Makes me feel proud to be an Egyptian. But I do have one question. Doesn't hemolytic anemia cause acholuric jaundice due to the unconjugated bilirubin not being able to produce yellow pigment unlike that of obstructive jaundice? Thanks in advance and great video as always

[@banaalani7216]

you’re a blessing!

[@MedicosisPerfectionalis]

Thanks a million! I really appreciate you!

[@dulangachamara2488]

Is it possible to have cyanosis in sickle cell crisis?

[@adnanabdalla9725]

Thank u you saved me after alot of problem with haematology even now I am regist. Of internal medicine

[@MedicosisPerfectionalis]

Awesome 👏 Thanks 🙏

[@Besho320]

You are the best

[@MedicosisPerfectionalis]

Thanks a million!

[@humbledude504]

I'm having a sc crisis right now... send some love

[@MedicosisPerfectionalis]

😍😍

[@humbledude504]

@@MedicosisPerfectionalis thanks!!! I love your videos and the fact that you took the time to educate people about this heartbreaking condition others and myself have to deal with

[@samar9211]

The presentation of our internal medicine sickle cell anemia lecture is your writings❤️ You are great man❤️🫡

[@MedicosisPerfectionalis]

Thank you 🙏

[@lebocarolinenkosi5533]

Sir you're the best👊❤ Thank you!

[@Ahmedddddddds27016]

Hello thanks for the amazing lecture I got a question in the skeletal changes how is caused by “extra”medullary hematopoiesis shouldn’t be Medullary haematopoiesis can you please clarify this.

[@dr.raihanapraweenhaque815]

I m final year medical student from NEPAL Helped me a lot to make notes... How can i search the answ in your fb page

[@MedicosisPerfectionalis]

Thanks for your comment! They have been buried down in the feed 🤭

[@fatimas.4408]

Masterpiece 🌸🤩🤩 Thank you sir

[@MedicosisPerfectionalis]

My pleasure 😇

[@rayanalfuhaid6232]

Seriously thank you so much!! Was wondering what app when you teach? And btw amazing haematology videos (I've been binge watching before my exams)

[@mariamaboutouk8849]

Thanks❤️😍 what about adenoid tonsil hypertrophy and the sleep apnea syndrome ?why it happen with sickle cell anemia

[@adelaidechamille9673]

Great explanation 👌

[@MedicosisPerfectionalis]

Thank you!

[@khalidk4069]

1-, infection. I think children have weak immunity and with sca its even weaker. 2- acute chest syndrome. 3- s.pneumonia, >70% cause of death in children with sca 4- also s.pneumonia 5- in sca, salmonella, but generally staph.aureus

[@MedicosisPerfectionalis]

The answer was found in the next video in the series.

[@khalidk4069]

Medicosis Perfectionalis yeah, the same , i have started watching this series 3 days ago. Life saver man.. life saver

[@MedicosisPerfectionalis]

Thanks a million 😊😊

[@ayanateel3535]

Hi everyone, ((Answers)): 1. Infection 2. Acute chest syndrome 3. and 4. Pneumococcal 5. Salmonella 6. S. Aureus 7. HbS 8. Pain

[@mayrama4229]

hello ... my exam exam will be after 6 days so plzzzz i wanna the part 4 of sickle cell .... plus .... g6pd anemia... as soon as possible... w thanks kteir kteir

[@MedicosisPerfectionalis]

Sure! I am working on that, No worries!

[@MedicosisPerfectionalis]

Sickle Cell Disease “part 4”: Diagnosis& treatmentkzbin.info/www/bejne/imaaqYOtgsqCeJo

[@MedicosisPerfectionalis]

Glucose-6-phosphate Dehydrogenase (G6PD) Enzyme kzbin.info/www/bejne/qJXNkIuHbqp5fLc

[@mayrama4229]

thanks a lot

[@MedicosisPerfectionalis]

You’re welcome! The next video on G6PD deficiency will be uploaded shortly... I wish you best of luck with your exam, and when you finish and have some time, please share my videos with your colleagues! Thanks a million!

[@المجد-ز9ر]

where can i find the correct answers plz

[@lililili1598]

ty a lot for your amazing videos !!!!!!!! kawazaki for hand foot syndrom no ?

[@a.s4993]

Thank you 😊

[@MedicosisPerfectionalis]

My pleasure 😇

[@nourhanfawzy3482]

Excellent 💕

[@johnsmith-sl7jt]

i got cured from sickle cell

[@romeolhk1008]

You are indeed much needed!!

[@MedicosisPerfectionalis]

Thanks a bunch!

[@drswetaruparel]

Very helpful !!! Thanks a lot... 👍

[@MedicosisPerfectionalis]

Absolutely! My pleasure!

[@gooddoctor4121]

Isn't unconjugated bilirubin insoluable in water?? So how can it be excreated in urine and give it cola cola like colour??

[@MedicosisPerfectionalis]

What actually happens is that the liver works overtime to conjugate as much bilirubin as possible (converting unconjugated bilirubin to conjugated bilirubin)…The conjugated is water soluble and will show up in the urine. In all cases of hemolysis, as long as the liver is normal, it will conjugate more and I will have high levels of conjugated bilirubin. Moreover, the hemoglobin released from RBC hemolysis is toxic to kidney tubules.

[@komaddog]

Hey, I've read that children can also experience acute chest syndrome.

[@MedicosisPerfectionalis]

May be, but it’s way more common in adults

[@faig7183]

could anyone share the answers with us?

[@zahraaabbas2378]

Sir does coca cola like urine discoloration occur with indirect hyperbilirubinemia ? I'm confused about this point, can you please clarify it ?

[@MedicosisPerfectionalis]

It occurs with obstructive and hepatocellular jaundice, not with hemolytic jaundice. So, the answer is no.

[@zahraaabbas2378]

@@MedicosisPerfectionalis Thank you

[@meshoahmed7988]

Great videos honestly, but you talk waaaay too slow. I always watch on 1.25x or 1.5x speeds and understand perfectly thanks!

[@MedicosisPerfectionalis]

You’re welcome! I think that’s fair.

[@pl640]

Is stem cell transplant is the only cure for SCD?

[@patient3841]

You only need to add a real pictures to your video For example (xray , signs , symptoms etc)

[@MedicosisPerfectionalis]

Copyright © issues are not easy to navigate.

[@godoglove115]

He talked so slow i could watch it on x2 speed and still understand everything he said with no problem

[@MedicosisPerfectionalis]

Thanks for your honesty

[@yasooop]

thank you for making such an interesting video. Very easy to understand :)

[@MedicosisPerfectionalis]

My pleasure...Thanks a lot for your words of encouragement! Best of luck!

[@haideralshreefy1569]

why gallstones are formed during SCA?

[@MedicosisPerfectionalis]

Sickled RBCs go to spleen-> phagcytosed by splenic macrophages--> extravascular hemolysis--> Hemoglobin is broken down into heme and globin. Heme is broken down into iron and protoporphyrin--> unconjugated bilirubin-> liver--> conjugated bilirubin --> dump it into GIT, since the excess of liver secretion is stored in gall bladder and since the liver is working harder to keep up with the excess hemolysis-> you have higher risk of forming gallstones. (Especially the bilirubin subtype of gallstones, not the cholesterol subtype). Hope it helps!

[@haideralshreefy1569]

thank you very much , this similar to my answer in exam >

[@MedicosisPerfectionalis]

Great!! Good luck!

[@دانيهصلاحصبيحعبدالكريم]

you are the best! keep going on :)

[@MedicosisPerfectionalis]

Thank you so much 😊

[@omerabdalaziz8158]

6:28 Coxsackie virus

[@neroetal]

Cool stuff ... when are you graduating to become a doctor

[@MedicosisPerfectionalis]

I have just graduated

[@neroetal]

Wow ... The best doctor you'll make... I hope you are planning on your post graduate soon

[@hadeelhassenaltalhi5365]

Splenomegaly occurs at childhood until adolescence the spleen is fibrosed right?

[@MedicosisPerfectionalis]

Probably, but patients are different. That’s why you need lab results to know the stage that the patient is in.

[@samyan_saleem4252]

Thnx:)

[@MedicosisPerfectionalis]

My pleasure 😇

[@ebrahembenbadis590]

Enterovirus A

[@مسكالختاممحمد]

Hand foot mouth syndrome is it kawasaki disease?

[@MedicosisPerfectionalis]

Coxsackie, not Kawasaki!

[@لجينالهاشمي-ش7ج]

I love you

[@sameworld1973]

Coxsackievirus

[@yarasobhey5844]

Who needs a surgeon, they are bad people 😂😂 I agree

[@abdelrahmanomar3156]

خخخ طب فين اجابة السؤال طيب 6:32

[@mahmoudalali-bn8ss]

Fuck textbooks!!!! Medicosis is the best

[@alial_iraqi261]

coxsackievirus

[@MedicosisPerfectionalis]

Correct

[@mahekshah10]

What is autosplencetomy lmaoo

[@DarthFernando57]

Coksakie virus

[@MedicosisPerfectionalis]

I am afraid I don't understand

[@DarthFernando57]

@@MedicosisPerfectionalis you asked the main cause of hand and foot disease

[@MedicosisPerfectionalis]

Excellent