Sulforaphane, Resveratrol & Capsaicin BLOCK Glutamine TRIGGER Ferroptosis

[@DrCaseyPeavler]

I feel so encouraged how many natural glutamine targeted nutraceuticals we have access to. Who else is encouraged?

[@jeffg4686]

Me - one person anyways. thanks for sharing - great info. Nobody should die from cancer with what we know.

[@fatimabonte-go3vy]

Same here

[@TheSpearoHeroes]

This is hugely encouraging. Especially considering how incredibly safe many of them are as well how many have a long history of safe use.

[@edwardcdg]

A thousand thanks, Dr. Peavler, for bringing to our attention alternatives to DON! Thanks as well for giving your references.

[@metabolights]

Thanks, Dr. awesome research

[@leadfoot8045]

THANK YOU SO MUCH DR. CASEY …. we all hope that your excellent lectures become Super Popular !!

[@DrCaseyPeavler]

God willing so more people have access to this information

[@raykinney9907]

This adds to my emerging desire to begin sprouting OG broccoli seed, and eating the sprouts lightly cooked with OG mustard seed sprinkled on them. Never sure, but always hopeful, of moving into a better path! Thanks for all of your effort to clarify such complexity!

[@raykinney9907]

Oh, AND, eat this outside in morning light with five OG eggs from pasture-raised chickens?!

[@raykinney9907]

With hot peppers?

[@DrCaseyPeavler]

Agreed broccoli sprouts have higher amounts of sulforaphane Ray!

[@egg399.]

Better to have sulforaphane supplements. 1 capsule =360g worth of broccoli and you don’t get all the downsides.

[@DrCaseyPeavler]

Or just a small amount of sprouts and the supplement. I like the alchemy of supplemental extracts with the natural food where it comes from.

[@vickyzimbalistmorrison9300]

You're saving countless lives with your valuable work. God bless you always!

[@DrCaseyPeavler]

Thank you for your kindness. It is my honor to share this info. God bless you also.

[@NZ_Andy]

Very good video, very glade to see this, fills in some missing pieces for sure.

[@DrCaseyPeavler]

I’m glad!

[@dodo-rq9we]

Really thankful for your efforts dr Casey. I need to study your video series to help myself.

[@DrCaseyPeavler]

I am honored to be a part of your healing journey!

[@simonclutterbuck6697]

Thanks for the info on co enzyme Q10, I stopped using NAC now I will be stopping the co enzyme Q10.

[@DrCaseyPeavler]

I’m glad it was helpful and actionable!

[@Will-zy3ru]

@@DrCaseyPeavler I am taking meriva curcumin and will start berberine phytosome and grean tea phytosome. I was taking cq10. My lymph nodes are enlarged after an orchiectomy (seminoma) and 9 weeks of chemo. My doctor wants to put me on chemo again. I am going to try the metabolic approach instead. Should I stop CoQ10? Will that interfere with the anticancer properties of the other supplements?

[@brannanwilliams5496]

When are you and Seyfried going to do an interview? We would to hear it

[@DrCaseyPeavler]

Great question. I want one with him and Tomas Duraj both.

[@brannanwilliams5496]

​@DrCaseyPeavler i have seen him doing a lot of youtube interviews recently maybe he will. Either way love the channel!! Thanks for the info

[@mcapital5539]

​please do it!! DrCaseyPeavler

[@DrCaseyPeavler]

I appreciate the encouragement and the push everyone

[@dawnchristine1344]

Thank you for sharing your experience and research.

[@DrCaseyPeavler]

You are very welcome!

[@cattleprods911]

Excellent Doc, you need to roll all this into a book someday

[@DrCaseyPeavler]

I would prefer a video series personally, but mostly because that is the way I prefer to learn

[@cattleprods911]

@ great, you’re and excellent teacher

[@raykinney9907]

@@DrCaseyPeavler Yes, video series are on-going, as scientific methodology is! IMHO.

[@DrCaseyPeavler]

Very kind of you all. I actually love doing these videos and sharing this information with you all. If only I could edit faster and more efficiently…

[@TheSpearoHeroes]

Another excellent video doc,

[@DrCaseyPeavler]

I am glad you enjoyed it!

[@wocket42]

Hi. Haven't watched all the video yet, but one thing about "press and pulse" I'm not sure of is what goes where. Which actions and supplements should be part of the pulse and/or only the pulse? Which actions and supplements would be part of the press? And what about the anti oxidants (like you mentioned Vit C and Q10), do they have no place at all or could they be part of the "press only" period? I think it comes down to these questions: 1) which actions and supplements are not harmful to normal cells/the body, but are to cancer cells (high doses all the time possible), 2) which actions and supplements may also be harmful to normal cells so should not be done all the time and 3) are there actions and substances that are as beneficial to normal cells as to cancers cells, so they should be limited, but maybe okay as part of a short recovery period after using stuff that falls under 2)? Regards Andreas

[@DrCaseyPeavler]

All great questions. This is the edge of science and it’s moving forward slowly due to lack of institutional support. But God willing these answers will come sooner than later.

[@pterakau]

The press and pulse;GKI

[@DrCaseyPeavler]

Thanks for your input!

[@DH-oi4kr]

How many mgs of resveratrol was the dose for cancer cell death ?

[@raykinney9907]

I'd suggest viewing all of the series of videos so far produced, as they are providing clarity toward your question.

[@DrCaseyPeavler]

I would have to dig through the methods. This was a in vitro study not in vivo so it may not be exactly possible to figure out from this particular study.

[@wocket42]

I don't have the answer, but it's always an important question. Many substances do wonders at high concentration in a petri dish, but these concentrations are often unobtainable in a human by oral consumption.

[@DrCaseyPeavler]

True.

[@ALFarrell-kv6ok]

​@@wocket42This is where we need to look at natural bio-enhancers. Piperine in black pepper hugely increases the bio-availability of turmeric. That only one example. There are other bio-enhancers.

[@drieman]

Are there lists of supplements the the research shows we should limit the use of or which might be useful for fighting cancer?

[@DrCaseyPeavler]

I don’t know of a comprehensive do and don’t list. It would be a very very long list that being said and probably not black or white. This is why it’s critical to work with someone local, who is licensed and like minded.

[@Gary65437]

Another good video. I have a question about taking an iron supplement. Does it help or promote cancer? Lower iron and leucine to limit mTor and cancer growth? One study shows ferritin @71 equals no cancer, above 127 =cancer growth in the liver. Ideal ferritin range is 25-80. Zinc seems to be a helpful supplement to beat cancer.

[@DrCaseyPeavler]

I would have to look into the data before I can comment. There is no question that cancer cells require iron. But that requirement could be used against them by leveraging ferroptosis…

[@stevemecke8984]

Curious, can you share the study inferring Ferritin above 127 = cancer growth in the Liver?

[@quintrahaman]

In the last study you covered regarding Resveratrol, the comparison was made between medium/low dose vs high dose. What would be considered “high” dose? Also, is DMSO a possible adjunct to addressing cancer?

[@DrCaseyPeavler]

DMSO has been reported anecdotally to be a cure all. I haven’t seen it studied much to be honest. And I’m all for cheap easy treatments. I would have to look at the methods but it was an in vitro study so might be impossible to translate that to the bedside. The dosing really needs to be a discussion between a patient and a healthcare provider. I do try hard to avoid dosing questions just because it can be taken as medical advice.

[@raykinney9907]

If I remember cautions about use of DMSO from a long time ago, it was suggested that topically it carries a lot of other chemicals through membranes, so careful attention to only use it under very controlled anti-contaminant conditions. In the sixties and seventies, my father went on a n of 1 experiment with using it for everything imaginable, and did not know much about contaminant transport risks. And, he did end up dying of a brain hemorrhage a few years into the 'experiment'.

[@DrCaseyPeavler]

I am sorry to hear about your dad Ray. That sounds horrible.

[@Roberto-cg2gr]

Any research on Moringa?

[@DrCaseyPeavler]

I’ve seen it for many other things but not cancer yet. I’m sure it will pop up one of these days.

[@doejohn8674]

What would the effects of sulforaphane, resveratrol and capsaicin be on normal healthy cells?

[@DrCaseyPeavler]

Interestingly enough, likely the opposite effect! Will stimulate the antioxidant response element through NRf2

[@doejohn8674]

@@DrCaseyPeavler Thank you, that is very good news!

[@DrCaseyPeavler]

You are very welcome. Nature is beautiful

[@raykinney9907]

@@DrCaseyPeavler Yah! Seems to be likely the case!

[@DrCaseyPeavler]

Beautiful synergy....

[@manapropaganda6247]

I would rather know about glucose inhibitors much more. Can you also talk about fenbendazol and also ivermectin in cancer treatment.

[@NZ_Andy]

There are so many glucose inhibitors, diet has a big impact, being in Ketosis etc.. so I think concentrating on Glutamine is a great idea as there was a lot less options. It's relatively easy to stop Glucose but not glutamine.

[@DrCaseyPeavler]

Sulforaphane, Resveratrol and Capsaicin all block glucose. I will dedicate several videos to the inhibitors of glucose uptake and utilization, including Fenben/Meben

[@stanleyyu2079]

MBZ (mebendazole) reduced VM-M3 tumour cell growth and invasion when evaluated under in-vitro and in-vivo conditions through inhibition of both the glutaminolysis and the glycolysis pathways. Therapeutically, fenbendazole and mebendazole are very similar. Fenbendazole can be quite effective when combined with calorie restricted high fat ketogenic diet.

[@stanleyyu2079]

For metabolic therapy, glucose can be controlled by eliminating the intake and trying to keep gki below 1. However, it is much harder to eliminate glutamine, because the body can make it itself. From the recent video interview, Dr Seyfried mentioned mebendazole (or fenbendazole), can be used to block glutamine: kzbin.info/www/bejne/roLLen2ultmHZ68 kzbin.info/www/bejne/roLLen2ultmHZ68

[@andrewrivera4029]

Go 0 carb, high fat a little protein

[@bernardcohen332]

Metastisized prostrate C being successfully stopped by anti androgen protocols. Will the natural products that you speak of actually kill the C cells?

[@DrCaseyPeavler]

I cannot give medical advice or make claims. But the studies and even more important the big picture being laid out in a constellation of studies point at exactly what Warburg and Seyfried have been saying for years. I’m just getting into the weeds and highlighting natural options

[@bernardcohen332]

As the antisndrogen therapy does not wipe out the C cells, but does stop their growth.

[@bernardcohen332]

@@DrCaseyPeavler give the relevant results of actual, published studies. You're free to do that without online, diagnostic accusations

[@DrCaseyPeavler]

I mean to be fair that is what I try to do in every video.

[@zainom786]

Would black seed oil have a good effect also

[@DrCaseyPeavler]

I have not seen it pop up when it comes to glucose and glutamine. That does not mean it’s not helpful, just maybe doesn’t have effects on these major fuel sources

[@dodo-rq9we]

Should I cut off vit c low dose now?? I need it to increase my immune count😢?!!!

[@donaglosser4272]

Am I right when I say you caution the use of Vit C?

[@DrCaseyPeavler]

Low dose IV or pretty much any dose oral vitamin C could be counterproductive and aid cancer cells acting as an antioxidant.

[@ALFarrell-kv6ok]

The natural phytochemicals/nutraceuticals in various foods and herbs too often have a low bio-availability that hampers efficacy. This is where we need to study up on bio-enhancers. For example, piperine in black pepper hugely enhances the bio-availability of curcumin. A google on natural bio-enhancers turns up others. I'm also curious about grapefruit. Grapefruit can strengthen the impact of many regular drugs, even to a dangerous degree. But could it beneficially strengthen the effect of some natural phytochemicals/neutraceuticals?

[@DrCaseyPeavler]

I think there are a couple things to note. Grapefruit is known it inhibit portions of the detox system know as cytochrome 450 system. That would different than increasing absorption with things such as pipeline which also affects cytochromes but also increases intestinal permeability of such compounds. BUT this is the kind of out of the box thinking we can use to increase serum concentrations!

[@barasra8847]

Like to commend your natural products affiliation than pharma extracts from these natural elements! Thanks!❤

[@DrCaseyPeavler]

Nature >> man made.

[@eliasvonbernstorff6762]

So these compounds only inhibit glutamine in the slc7a11 and other glutathione production pathways, there fore they have no effect on reducing cancer cell ATP generation from glutamine, correct? Therefore a different compounds is needed to starve the cancer, this made it vulnerable to oxidative stress

[@DrCaseyPeavler]

That is not completely accurate. I am highlighting in this video the actions on SCL1A5 glutamine uptake channel inhibition. SFN, RES, CAP all have many other actions on glucose and beyond. That is what makes them so special.

[@DrCaseyPeavler]

You may benefit from watching: kzbin.info/www/bejne/hWXWkp2mj8SGfK8 To better clarify and understand the overall goals of metabolic therapy.

[@eliasvonbernstorff6762]

@@DrCaseyPeavler I think you may be mistaking the contents of this video with another. In the first 30 seconds you say this video is about slc7a11. Are you saying SFN,RES,CAP all has other effects than just inhibiting this pathway? how come you didn't mention or include that in the video?

[@DrCaseyPeavler]

Yes that is what I’m saying. EGCG or Curcumin may block 20 different pathways. The reason is because it would be about an hour video and this part of the series is about glutamine.

[@bobthrasher8226]

Would iron deficiency play any inhibitory role in ferroptosis? In other words would you check an iron panel to make sure iron is sufficient during cancer therapy? Would boosting iron to high normal ranges possibly be beneficial in supporting ferroptosis during cancer therapy?

[@simonclutterbuck6697]

Cancer tumours will collect as much iron from the blood as they can, which is why anemia is usually used as warning signal for a cancer diagnosis. I have increased my iron intake. Mainly to improve my blood oxygen levels than improve ferroptosis.

[@bobthrasher8226]

@@simonclutterbuck6697 Do oncologists routinely monitor and supplement iron as necessary or only if iron-deficient symptoms present? It seems like a cancer would have to be fairly advanced to lead to anemia.

[@simonclutterbuck6697]

@bobthrasher8226 I have a small 1 inch round colon tumor so they don't have to be big to have an impact on your iron levels. My levels are about 50% lower than where it's recommended to be. I also have kidney problems so I am getting bloodwork done every 4 weeks for that, so I can see my iron levels regularly, even though I am supplementing iron it's not improving what is in my blood stream by much. I figure when it starts showing it's getting higher in my blood tests it will indicate the tumor is dying off. I have to call the cancer co ordinator today to see what tests I can get to see if it's shrinking, as I refused the surgery and they said chemo or radiation wasn't nessacary, which was when they thought I was having the surgery. So I am not sure what they will say as I am being uncooperative with how they want to treat me lol. They have not offered to give me an iron infusion so not sure if it would be part of their cancer protocol.

[@DrCaseyPeavler]

It’s possible. This issue is ferritin is the main way we check iron stores and it is often “falsely” elevated in cancer patients because it is an acute phase reactant and will elevate in setting of inflammation and cancer is highly inflammatory.

[@DrCaseyPeavler]

Most oncologists are also hematologists so they will routinely check ferritin, TIBC, B12 and folate. Anemia in cancer is due to chronic inflammatory state called anemia of chronic disease or can be related to chemotherapy. It’s harder to detect iron deficiency in cancer patients. B12 and folate deficiency is easy to detect for any patient, cancer or not.

[@insbpo2679]

Your comment about NAC, Vit C, etc perhaps being harmful when cancer exists is very interesting. Do you think the same applies to Anthocyanins?

[@DrCaseyPeavler]

Hard to say. Likely would not want to take any supplements that act as antioxidants. If you were to eat some wild blueberries for anthocyanins likely not harmful, but could affect your GKI....

[@egg399.]

Was it just vitC we shouldn’t have in small doses or coq10 as well? Would a large dice or oral vit c be over the 5g mark or is that still too low? If we can’t get IV vit C can we take liposomal/buffered vit c orally to give a therapeutic action against C cell to increase ros by hydrogen peroxide?

[@DrCaseyPeavler]

Any dose of oral would act as an antioxidant. Even low dose IV-C would act as an antioxidant. If it were me, I would not take CoQ10 with cancer.

[@egg399.]

@ Blimey, that’s in so many protocols! It’s in mine. My note on use is that it helps vitamin E stay in antioxidant form. Now i’m thinking if I should ditch the tocotrienols as well? yes, I see we want to increase ROS and ferroptosis / apoptosis and antioxidants will help protect the c cells. I’ve had 30% reduction. Do I change my tack and start withdrawing items?

[@DrCaseyPeavler]

Would need to discuss these nuances with a knowledgeable healthcare provider to be honest.

[@shajjj455]

But resveratrol has very poor absorption in human studies. Wouldn't pterostilbene be better option?

[@DrCaseyPeavler]

I have not had a chance to study pterostilbene for cancer yet. And I haven’t seen it pop on my radar during investigation metabolic agents for cancer. But it would not surprise me

[@shajjj455]

@DrCaseyPeavler it is supposed to be a more absorbable form of resveratrol

[@DrCaseyPeavler]

In theory it should function the same then. I’m just saying I haven’t seen literature on it.

[@eliasvonbernstorff6762]

So IS there a way to fully inhibit cancer cell glucolysis and glutaminesis through supplements… because IF there is then the ketogenic diet would not be necessary and we would be able to eat a carb diet and harness the unique benefits only possible on such a diet while still starving the cancer.

[@wocket42]

I have no clue, but often it's not black and white when taking about millions of cells with billions of receptors. No substance will block all receptors on all cells. And there might be a concentration thing, so higher glucose levels will always be worse than lower ones. And there is the effect of ketones themselves which may or may not be easy to supplement.

[@DrCaseyPeavler]

Why is the ketogenic diet beneficial? If you say lowered blood glucose you would only be partially right. If you dig into Seyfried’s papers, they believe the benefit is lowered insulin signaling and elevated ketones. So there may be dozens of potential targets along the glucose and glutamine systems, but a ketogenic diet with exogenous ketones is the foundation for a reason.

[@eliasvonbernstorff6762]

@@DrCaseyPeavler So... even on a carb diet that at the same time inhibits cancer fuel we still would be producing insulin which promotes growth... however I think that the unique benefits you could get only on a carb diet WOULD outweigh that. We could consume an amount of exogenous ketones to gain the anti cancer benefits of the ketones while off the keto diet, basically using it as an anti cancer supplement like curcumin.

[@eliasvonbernstorff6762]

@@wocket42 Why would they be hard to supplement? I was thinking just taking ketone esters would give us the effect, do you not think this ketone amount would give us the effect or not enough of it? From what I have read the unique benefits only possible on a carb diet are powerful and finding a away to incorporate them, I think would do alot.

[@eliasvonbernstorff6762]

@@DrCaseyPeavler I thought starving it was the main purpose.

[@raykinney9907]

Hmmm yes, encouraging that so many of the spices and plant active ingredients used in asian medicine historic practices continue to become more clarified how they have been having biologic efficacy as preventive and supportive benefits. We would probably be better off not ignoring as much prehistoric 'medicine' usage practices, but just take their past usage as clues that past acquired knowledge toward effective medicine practices by other medical paradigms than our 'western medicine current paradigm for profit' dogma tries so often to negate those efficacies 'out of hand' via hubris. There remains a wealth of prehistoric knowledge untaped by our lack of appreciation of this oral history conveyance of knowledge through time I am fascinated by oral history necessity to retain and accurately communicate over vast timeframes. IMHO.

[@raykinney9907]

Not to say I negate the historic asian long usage of written language, but I'm thinking about much deeper timeframes too (e.g. deeper than 50KA).

[@DrCaseyPeavler]

It’s is out of complete arrogance traditional Chinese medicine and Ayurvedic medicine is forgotten, ignored and demonized by main stream…

[@raykinney9907]

@@DrCaseyPeavler Imagine what complexities of knowledge of latitude barcodes of foods and medicines we were evolutionarily attuned too site specifically, are now lost!?! A huge void for pharma to try to fill, but without the specificity of quantum biology guiding. Jet-lag 'catastrophe of normal'.

[@eliasvonbernstorff6762]

Say one compound inhibits this step of the pathway... and there is a different compound inhibiting another step of the pathway. Is that even helpful?.. Don't we just need to disrupt a single step in the pathway for it to be impossible to complete it? For example these mulitple compounds that inhibit the SLC7a11 pathway. Trying to figure out if there is any benefit to use for example resveratrol when already taking curcumin.

[@DrCaseyPeavler]

Great question. The honest answer is we don’t know yet. But in a very similar way we treat HIV, Tuberculosis, a multiple anti-viral and antibiotic approach seems to make sense for cancer as well. You hit it so many ways that it has no way to adapt and become resistant

[@eliasvonbernstorff6762]

@@DrCaseyPeavler Are there more than 1 pathway in which the cancer cell can make something? for example glutathione or ATP. If there is THEN more than on disruption would be necessary to fully inhibit it. And are the pathways in cancer cells and healthy cell the same?

[@DrCaseyPeavler]

To answer your last question, absolutely. Cancer is us. Cancer comes from us but hijacks our system of growth and protection. This good thing is that normal cells are metabolically flexible, cancer is not.

[@miketzlambertelkins2900]

Im diagnosed with primary peritoneal carcinomatosis, no chemo yet, my dr is giving me glutathione shots, nac, i take vit c. Did you say thats not good or good? I taking cats claw, Shatavari, keto diet, exercise, trying natural remedies. Onocologist wants me on chemo ASAP, but my numbers were coming down with cats claw, shatavari, candida cleanse, parasite cleanse. So she added the glutathione shots to boost immune system

[@DrCaseyPeavler]

Context is everything and I am not your doctor, as you are well aware. But if it were me or anyone I love had cancer. There would have to be DARN good reason to be on glutathione or NAC….I would be very concerned if they don’t seem concerned or are not explaining why they are doing it..

[@miketzlambertelkins2900]

Why is it bad again? We are trying alt ideas to chemo. It had seemed like a good idea, but I will tell her why it's not good idea. I am trying ivermectin next. Wish I cud find an intergrated onocologist here in TN

[@DrCaseyPeavler]

I don't mean to discourage you, I am going to assume your name is Mike. And don't beat yourself up. You were doing what you thought was right. If you are undergoing liver damaging chemo, then it would make sense to try to protect your liver. BUT, cancer is part of you and me. Its our cells gone rogue. They have the same pathways our normal cells have. They even hijack those pathways for their own good and protection. One of the major ways is through the overuse of the NRF2 pathway. The NRF2 pathway is the endogenous antioxidant response element. It up-regulates glutathione and glutathione peroxidase. BUT it needs NADPH from glucose, glycine, cysteine and glutamine to make that system work. If we were to give cysteine (NAC) or glutathione, we would be giving cancer the advantage. One of the main reasons for restricting glutamine is to restrict glutathione production. When cancer antioxidant response is impaired, it makes them exquisitely sensitive to ROS/RNS (IV-C, HBOT, radiation, chemo). Hope that makes sense.

[@napaman2104]

Dr. Peavler slightly off topic but does taking a supplement that contains Glutathione contradict our efforts to limit or cut back on Glutamiine? Thank you

[@scottmaas1959]

yes he stated before increase glutathione via NAC is not a good idea during treatment.

[@napaman2104]

Thanks, missed that

[@DrCaseyPeavler]

Absolutely. 💯

[@eliasvonbernstorff6762]

@@DrCaseyPeavler what about increasing glutathione by making the liver make more (therefore not taking a supplement)?

[@DrCaseyPeavler]

It’s tricky business. Why are you concerned with increasing glutathione? I don’t mean to minimize or shame your concerns by all means. Just curious

[@forexcharts281]

What are the doses?

[@raykinney9907]

I'd suggest viewing all of the series of videos so far produced, as they are providing clarity toward your question.

[@DrCaseyPeavler]

Thanks Ray. I do not give doses in these videos. It could be considered medical advice. These videos are to provide awareness mostly. Your integrative medicine doctor will help you with dosing!

[@VandanaChaudhry-x3s]

Can you tell how to cure schizophrenia

[@DrCaseyPeavler]

No I cannot. But I can tell you the closer you are to the equator, the incidence of most disease plummet. So is light stability, strong UV a factor? Yup.

[@metabolights]

🙌

[@DrCaseyPeavler]

I hope you enjoyed!

[@edhcpa3935]

This guy is a brainiac. How does a cancer patient get to join one of your zoom meetings?

[@DrCaseyPeavler]

I am in the process of launching some new things in the next month or two. I am going to do a monthly metabolic therapy course, I am going create an online private community with free speech intact, and I am going to create self-paced courses as well. I do offer personal one on one educational consults also.

[@edhcpa3935]

@ if you can, please place my YT contact on your list for the webinar classes or kindly make a YT announcement so wanna be participants can register. Where can folks sign up for one on one sessions if interested? Do you have a website address with a link for that possibly? Thanks in advance for the additional information.