You mention that tapering is difficult with long half life drugs. Why? It would seem that the long half life provides an inherent taper
@NicholasDowney11 ай бұрын
The issue with longer half lives is the inherent ability to suppress natural production of testosterone. Shorter acting compounds do not exist long enough in the serum to cause sufficient negative feedback. It's the reason why someike to use rapid dissolvable testosterone to stimulate LH production
@fredwells740311 сағат бұрын
The study only looked at dosages as low as 125mg per week, which in most cases will still give you slightly supraphysiological serum levels. What if the taper was designed to have your serum levels BELOW your normal natural levels? Maybe aiming for a stable 200ng/dL by using a very low dose? Would that still be suppressive? Wouldn't your body start trying to compensate are make T by itself, if your normal natural level was 600? This maybe it would take longer, but this would allow you to avoid the crash where you're essentially at zero, and avoid taking SERMs. I have a hard time believing that any dose of testosterone is suppressive. If you injected 5mg per week, would that really suppress you at all? What about 0.5mg? The way I think of it, having a serum level that's above your natural state is really what suppresses you. If you maintain a below natural level with exogenous hormones, your body could still start compensating with its own hormones. I guess tldr, my idea is not to taper down from 500mg/week to 125mg/week. But rather taper from 125mg/week down to 20mg/week, very slowly, allowing your body to respond in real time. What do you think of this idea?
@antondeklerkdrtony3d41211 ай бұрын
Doc looks leaner💪 so in my experience, tapering down test prop is a big no cause you lose the lh rebound where the lh over shoots my best advice is to just keep e2 low and stop and see after 3 weeks if your test recovered
@iamthefiremanjj10 ай бұрын
For me I did a taper using test prop subq injections . I added 250iu hcg twice per week . For 4-6 weeks I tapered by 3mg daily each week . It looked like this 25mg prop daily 18.75mg prop daily started hcg 15mg prop daily 12mg prop daily 10 my prop daily 7 mg prop daily Stopped test Started 12.5-25mg enclomophine daily for 4 weeks . I was at a 989 natural test level and I ran a cycle and did TRT for 2 months after as a bridge and had to come off due to sleep issues etc . So that’s my protocol set up. I’ll let everyone know where I am at with this and hop I avoid a crash doing this . While on TRT my levels were good 1,000-1,200 total t estrogen 40 or less , no AI I also implement a high fat animal based diet to support hormone production during this time .
@N-xi2zh11 ай бұрын
Nice info.
@user-dt7gq1pt6e11 ай бұрын
Test cyp half-life is 8 days to taper off you would downgrade the dosage at 6 day intervals: if the starting dosage is 500; 6 days later at 300; 6 days later at 180; 6 days later at 100; 6 days later at 60; 6 days later 30; 6 days later 20; 6 days later at 10; 6 days later final dosage at 5. Nearly 50 days to taper off a 500 dosage… or would it better to cut dosages in half every 8 days?
@LKF-lz8do7 ай бұрын
Hi Nicholas, thank you for your content and your help to the community. Will you do a video about clenbuterol?
@N-xi2zh11 ай бұрын
HI Doctor. I have a question regarding Test and DHT or even TEST cream safer and better than say primo and dbol? And safer than test, and more 5ar activation as there is more enzyme activity in the skin. Wouldn't we be able to be healthier and have one medicine only if we use Testosterone Cream transcrotally, hence fufilling DHT, TEST, and 5arii pathways? Couldn't I use that for TRT/HRT and use it twice a day? Whether homebrewed or prescribed? You are looking healthy and lean by the way. :) Thanks for any help. I am using it to help heal post finasteride syndrome (though I was cured). I am using it for mood, fitness, confidence, sexual health, and also just motivation in life. I really need some help and kindly appreciate it.
@HotSizzleTV_11 ай бұрын
What is the dosage for Clomid, tamoxifen, Enclomiphene? I am doing test 250mg and anavar 10-20mg I’m in my 6 week of this cycle. I just don’t know the dosage to pct with the 3 compounds I listed above.
@wellscraft11 ай бұрын
I was thinking that if a person suddenly stopped testosterone, they would then have too much estrogen from the remaining testosterone converting to it, and not being replaced with fresh testosterone. If one were to taper down the dose, the estrogen would be better balanced with the fresh testosterone, even if it is less then before. Also wouldn't a drastic change in hormone levels be more likely to cause acne?
@NicholasDowney11 ай бұрын
That definitely makes a lot of sense
@MetalheadAndNerd11 ай бұрын
That's why PCT includes at least a SERM.
@Charles-jo8ub8 ай бұрын
It makes sense to taper down body and estrogen will rebalance better
@MetalheadAndNerd11 ай бұрын
Sorry, but your reasoning in the first part seems totally off to me. When tapering off Prednisolone the goal is to accustom the body to the lower cortisol level and not to restart it's own Prednisolone production. These are two totally different goals. As you later stated: Tapering off Testosterone would only drag out the period where there is too little testosterone to continue building muscle but too much testosterone to restart the natural production. That and only that is the reason.
@NicholasDowney11 ай бұрын
The body doesn't produce prednisolone. The goal is not to accustom the body to lower cortisol, as this would imply that GCRs or the cytosolic components responsible for the end response are altered which hasn't been proven. Administration of exogenous glucocorticoids can suppress the hypothalamic-pituitary-adrenal axis (HPA). Abrupt cessation, or too rapid withdrawal, of glucocorticoids in may cause symptoms of adrenal insufficiency. The reason I chose this example is due to similarities between exogenous glucorticoids and ACTH suppression and Testosterone and LH and FSH suppression. Tapering off with a short acting testosterone, in theory, would work similarly to how tapering glucorticoids work. Your assumption would imply that most doses of testosterone are suppressive which is correct in the instance of Test E but not in shorter acting esters.