Which Neurotransmitter is the Most Stimulating? (Neurotransmitter Lore)

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This is the neurotransmitter tier list - I hope you find this video to be very stimulating!
I guess this is neurotransmitter lore ;)
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Join the Community Discord! - / discord
0:00 Intro
4:53 Ad
6:15 Dopamine
9:30 GPCRs
14:39 Noradrenaline
17:42 Serotonin
21:25 Glutamate
24:55 GABA
27:00 Acetylcholine
29:35 Banana Outro
30:21 Dopamine (again?)
Team
Writer/Producer/Thumbnail Artist - That Chemist (Joey)
Lead Animator/Graphic Designer/Editor - David
Vesicle Animator - Chogi
Lead Writer/Biochem Research - Exergonick (Nicholas)
Writer/Biochem Research - Trev
Chemistry Assistant - Maurice
Technical Lead - Polygorg (Georg)
Rigging/3D Systems Engineer - Robot Chicken
Acknowledgements
Ballerene for his ballin' biochem help
Music - A huge thanks to @S3RL for letting us use his music in the video!
"Dopamine - S3RL feat Sara"
Contact S3RL - withkoji.com/@S3RL
References
Dopamine: www.kegg.jp/pathway/map00350+..., www.kegg.jp/pathway/map04728, www.genome.jp/pathway/hsa05012, www.kegg.jp/pathway/map05012+...
Noradrenaline: www.kegg.jp/entry/M00042
Serotonin: www.kegg.jp/pathway/map07211, www.kegg.jp/pathway/map04726
Tryptophan: www.kegg.jp/pathway/map04726+...
Glutamate: www.kegg.jp/kegg-bin/show_pat...
Gaba: www.kegg.jp/pathway/map04727
ACH: www.kegg.jp/pathway/map04725
Dopamine:Function & Symptoms: tinyurl.com/4cbw3ufd
Acetylcholine in Learning and Memory: doi.org/10.1016/J.CONB.2006.0...
Cholinergic Crisis: doi.org/10.1007/978-3-211-792...
Cholinesterase Inhibitors for Alzheimer’s: doi.org/10.1016/S0011-393X(03...
Myasthenia Gravis: doi.org/10.1212/CON.000000000...
Cholinergic Receptors: tinyurl.com/bdwec9j7
Otto Loewi: doi.org/10.11622/SMEDJ.2014002
Acetylcholine (ACh: tinyurl.com/5d4swfbm
GABAergic Dysfunction: doi.org/10.1016/J.SEMCDB.2021...
GABA Receptors: doi.org/10.1007/S11011-014-95...
The Neurobiology of Addiction: tinyurl.com/mryvu9bz
Mechanism of Action - Benzodiazepine: tinyurl.com/3dycz4bu
Anxiety Disorders and GABA Neurotransmission: doi.org/10.2147/NDT.S58841
Gamma-Aminobutyric Acid (GABA): tinyurl.com/mw58v55v
Molecular Mechanisms GABAB: doi.org/10.1126/SCIADV.ABG3362
GABA and Glycine Receptors: tinyurl.com/2p9uvtrd
GABA Receptor: tinyurl.com/yc6tv6cz
NMDA Receptor-Dependent LTP/LTD: doi.org/10.1101/CSHPERSPECT.A...
Glutamate and Depression: doi.org/10.5498/WJP.V11.I7.297
Glutamate Transporter 1: Target for the Treatment of Alcohol Dependence: doi.org/10.2174/0929867128035...
Glutamate: What It Is & Function: tinyurl.com/msk3z6we
Glutamate Receptors: doi.org/10.1016/S0301-0082(01...
The History of (MSG): tinyurl.com/yt864se7
Serotonin Syndrome Case Report: doi.org/10.7759/CUREUS.22468
Brain Serotonergic Circuitries: doi.org/10.31887/DCNS.2010.12...
Abnormal Cells Constipation: doi.org/10.1080/0036552997500...
Serotonin: tinyurl.com/5d4swfbm
Dopamine D1 Receptor: doi.org/10.3389/FNCEL.2021.80...
Dopamine in Motivational Control: doi.org/10.1016/j.neuron.2010...
Norepinephrine: tinyurl.com/5cmbnma2
Adrenergic Neurons and Receptors: tinyurl.com/2s4fmw2m
Noradrenergic Synapse: tinyurl.com/bdwec9j7
Adrenal Stress Hormones and Enhanced Memory for Emotionally Arousing Experiences: doi.org/10.1201/9781420008418...
Dopamine and Noradrenaline in the Brain doi.org/10.3389/FNMOL.2019.00334
Noradrenergic Synapse: tinyurl.com/bdwec9j7
Dr Julius Axelrod: doi.org/10.1093/EURHEARTJ/EHA...
Adrenal Gland: tinyurl.com/mv4jpauk
Locus Coeruleus-Norepinephrine: doi.org/10.3389/FNAGI.2018.00...
Food-Related Reward Signals: doi.org/10.3402/FNR.V55I0.5955
Drugs Disrupt Presynaptic Dopamine Neurotransmission: doi.org/10.1016/J.NEURON.2011...
Biochemistry, Dopamine Receptors: tinyurl.com/yc33pt4m
Parkinson’s Disease: tinyurl.com/y84d2p7u
Signaling Dopamine D1-like Receptor Activation: doi.org/10.1016/J.PHARMTHERA....
Ventral Tegmental Area, in Rat: doi.org/10.1016/j.neuroscienc...
Arvid Carlsson: doi.org/10.4103/0019-5545.58907
Anatomy and Function of VTA : doi.org/10.3389/FNCIR.2022.86...
Dopamine in Motivational Control: doi.org/10.1016/j.neuron.2010...
Relevant human Proteins found in RCSB PDB RCSB.org 10.1093/nar/28.1.235
And predicted proteins found at www.uniprot.org/

[@That_Chemist]

Grab Atlas VPN for just $1.83/mo + 3 months extra before the SUMMER DEAL expires: get.atlasvpn.com/chemist 👈 #ad #atlasvpn

[@nictibbetts]

Dat neuronal chemical messaging system fuckin wit me brain chemistry n shit fu real homie got me thinkin thoughts n shit got my brain doin dat neuroplastic shit stretchin n growin.

[@misterhat5823]

A VPN shill. Thumbs down.

[@nictibbetts]

@@misterhat5823 based

[@junius71]

From what I understand, MG isn't necessarily the absence of the the receptors as much as it is that the immunoglobulins are blocking Ach from reaching its target on the receptors which is why its usually treated with indirect parasympathomimetic which block Ach-esterase from breaking down Ach and increasing its concentration at the NMJ

[@WhiteHazee]

I love it when you mix chemistry with pharma/biochemistry. But you can't put dopamine in C and put this vulgar norepinephrine in S 😢😢😢

[@CompletelyNormal]

Some of the other neurotransmitters not mentioned in this video get really weird. My favorite is endocannabinoids because they break all the rules. They were one of the last neurotransmitters to be discovered, and we still don't know everything they do, but the short version is that they work backwards. We only discovered them because someone realized, "Hey, weed clearly does something to your brain and it doesn't seem to be interacting with any of the neurotransmitter pathways that we already know about."

[@gandalf8216]

I beg to differ, I consider the serotonin-dopamine pathways to the hippocampus and various areas of neurogenesis far more impactful, and novel. You know, how memories are formed and ultimately biased based upon emotional state and present focus/motivation. The endocannabinoid system is a simple regulatory system, not that different from GABA and glutamate, both able to be either inhibitory or stimulating depending on the site of the receptors. Serotonin systems (not a typo) are self-regulatory, due to stochastic distribution of receptor densities, which in turn regulates "direction" (or rather, the natural selector) of fresh neurons and their migration paths. I mean, the endocannabinoid system is pretty cool, because I have a weak spot for simple but effective systems, but the serotonin-dopamine pathways for memory formation and brain adaptability is too cool for anything to top off.

[@profpuffofficial2]

@gandalf8216 wait till you discover metabolome-gut-mitochindrial-serotogenic systems and their interaction with the brain

[@cyan_oxy6734]

​@@gandalf8216I think serotonin should be left alone. Like seriously all these SSRI antidepressants are like kicking your TV to make it work again. Sometimes it works, sometimes you make it worse and sometimes the TV just dies. Just give me opium and koka leafs for depression like in the good old days. It surely can't be that hard. All these new psych meds are easily perscribed because they feel like shit. Just give me something that makes me feel good. People could freely buy opium in pharmacy for centuries but somehow in the last 100 years everything went to shit.

[@AnthonyBolognese710]

@@cyan_oxy6734natural supplements like you mentioned, and deadlifts for depression. Seriously - lifting heavy weights [safely] really helps stave off depression.

[@berrybee9242]

@@cyan_oxy6734 one of the dumbest takes ive seen all day

[@1.4142]

Low noradrenaline: anxiety High noradrenaline: intense anxiety

[@unocualqu1era]

High GABA: I sleep. High noradrenaline: REAL SHIT

[@lanwish]

Well, i have ADHD. Noradrenaline makes me calm, sometimes even makes me sleep.

[@unocualqu1era]

@@lanwish True, but I think it's incredibly specific. As in, too little noradrenaline and you'll feel nervous, too much and you'll feel either very nervous or very sleepy... if it's just the right amount then you'll feel calm and focused. Finding a balance of neurotransmitters with ADHD is very important and difficult until you find out exactly what you need. I struggled with that for years but thankfully I found my spot as well.

[@lanwish]

@@unocualqu1era yh I know I just shared it as an interesting story. My GAD was killed by a SNRI.

[@NoSaysJo]

​@@lanwishyou don't have adhd, cope harder lazy dog

[@kubas3816]

As a med student, this video is rlly helpful. Never thought I'd see That Chemist go in this direction. Thank you

[@That_Chemist]

It’s because we wanna cover topics which are important, and our team has a fair amount of biochem expertise :)

[@prapanthebachelorette6803]

I’m glad you do something biochem stuff 😊

[@feelinghealingfrequences7179]

never to late to drop out of med school and become a podiatrist and have a balanced work life

[@travv88]

14 minutes of dopamine explanation and then it is ranked C because cheese starts with C.

[@unknownbandit6509]

i love how i get my dopamine and serotonin is a tiny hardworking walking chemical that carries a ball of neurotransmitters to my neurons. you go lil guys!

[@That_Chemist]

let those sacks of neurotransmitter MARCH

[@0alalune0]

If you want to learn more about them: kzbin.info/www/bejne/b4O4eX2eqNCKZpI

[@dickartist]

truly the molecular Sisyphus

[@MoreTrenMoreMen69]

@@That_ChemistONWARDS TO VICTORY MY PRECIOUS NEURO HOMIES

[@ujfujf422]

@@That_Chemist Do all neurotransmitters have them lil guys?

[@nicolaserrazuriz4]

As a person with depression and generalized anxiety, neurotransmitters are important for understanding your condition, i am also planning on majoring as a biochemist and this video is really interesting, thanks!

[@That_Chemist]

They certainly are, and discussing your condition with a physician/psychiatrist early in life can save you a lot of unnecessary grief Stay well :)

[@darthmaul197]

How are you going to become a biochemist with depression and generalised anxiety

[@sigmamale4147]

@@darthmaul197 really dude ?

[@fragileomniscience7647]

Except that psychiatric conditions have not much causally to do with neurotransmitters, but their release and breakdown, via microglia activation, excess cortisol, altered DNA methylation.

[@earlgrey2130]

@@sigmamale4147 It's a legitimate question. If we are talking about a diagnosed clinical depression and anxiety disorder, then it's already a big challenge for most patients to just get up in the morning, eat a meal and somehow get through the day as they are so exhausted. Going to uni for a tough 8hour day of lectures is out of the question. Especially since depression massively decreases your ability to focus. He wont remember 80% of what was said in those lectures and he wont have the energy to re-read it in the evening. Then you add the anxiety, which makes it hard to go out, be amongst large groups of people and deal with stress. That is literally all campus life consists of. It's not impossible to get a degree while carrying depression. I've seen people do it. I've done it myself. But it's extremely hard. You need a lot of help and you will need to cut corners everywhere. Forget about having a fun time or even participating in student life and activities. And you need to compensate for all that extra difficulty with strengths in other areas that are above average. Like being highly intelligent, having a very strong social circle (which few people with depression have. They all leave after a few years) or being lucky enough to respond really well to anti-depressants so you can chemically carry yourself through that time.

[@mrpickles619]

You struck a great balance of discussing details of neurotransmitters while still being generally understandable to a non-chemist/non-biologist. I'd watch more videos talking about other neurotransmitters and/or talking more in depth about their functions. Also the S3RL x That Chemist crossover is as awesome as it was unexpected.

[@That_Chemist]

His music is great - Jole is a nice guy :)

[@jva4120]

This man just summarized half a course of cellular physiology in roughly 14 minutes. Impressive.

[@Forehead_Fergus]

Babe wake up, thatchemist dropped a new video

[@That_Chemist]

sorry it took SO LONG :/

[@jajastacha3796]

Ok

[@regulatorjohnson.]

Don't call me that...

[@TrianglePants]

yawn

[@thomasrussell4674]

A tap on the shoulder from dopamine

[@katoka5904]

I'm hyped for when my chemistry studies at uni start in 2 months and I can finally understand your videos

[@MoreTrenMoreMen69]

as a neuroscience student, when i saw this on my recommendations my neuronal pathways lit up like “YEAHHHH”

[@Linguae_Music]

DMT is the coolest neurotransmitter. In the visual cortex of laboratory mice, the proportional concentration of DMT compared to Serotonin, was found to be approximately 1:2 under normal conditions. :D (this is even more surprising given its short metabolic halflife of about 5 minutes.) That's why from now on, I will be referring to it as a neurotransmitter. I wish they would actually study it more. It has effects on neurogenesis, and neuron repair (at the very least by downstream activation of BDNF), and also plays a role in plasticity.

[@ollie6133]

For a chemical to get the status of being a neurotransmitter it must satisfy four conditions. 1: it's synthesized intracellularly. 2: it's stored intracellularly. 3: it's activated and then consequently 4: it's deactivated. I'm not saying DMT couldn't be a neurotransmitter, but an abundance of the stuff compared to serotonin isn't sufficient to say it is.

[@thedarkroomlondon]

For clarity, I presume you mean N,N-DMT in this case, as opposed to any of the common (4-PO, 4-HO, 5-MeO, 4-AcO) or uncommon analogs? IIRC there's some recent research that's found some quantities in human CSF, but the jury's out from what I've read as to if we can really call it an endogenous neurotransmitter... yet! "Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain" 2019 makes for an interesting read, regardless.

[@colingeissler2540]

wow so much effort has been taken into creating this video. The fact that there are these quick definitions/ extra context is provided is just so convenient, so I dont have to spend as much time looking things up myself. Thank you sir

[@reformlabs1050]

It took some effort but completely worth it! This is what I was hoping for exactly, to cater to the audiance that wants a more deeper understanding of stuff without going on Google to look it up.. I'm glad my inference was correct, thanks for the feed back :) David here, the guy who made the visuals for this video...

[@Chemiolis]

Thank you That Biochemist for this informative video

[@That_Chemist]

Thank you Dutchiolis

[@vwvqr]

Now kiss

[@fiftheyecanopener]

​@@That_Chemistpsychedelic agents tierlist?? ily btw🥺🥺🥺

[@morgan0]

it would be really cool if you did a video on the pathways from calories to energy for the cell, both for glucose and for ketones

[@That_Chemist]

Yeah we wanna do a video like this eventually

[@ericdaugherty5607]

I would be stoked on a video pertaining to obscure neurotransmitters that are not commonly known about and the functions they have in the body!

[@Jasonmakesvideo]

There's a name for those and I've been trying to remember it for the past 3 days

[@ZucchiZ]

Rat: gives up food for the sheer pleasure of *self stimulation*

[@ShockedCaucasian]

This video was amazing! I learned so many nuances to things I thought I fully understood, and this just makes me want to pursue my biochemistry dreams even more haha. Thanks for the awesome 3d models of not only the neurotransmitters themselves but the receptors too! I had never known there are so many varieties of receptors for each neurotransmitter, Awesome content as always 😎

[@Rachel_Banner]

Just discovered your channel and am binging the videos, but I just had to let you know that the joy in your voice during the little singing bits in this one was especially wonderful. I couldn't help but smile! As someone who is not good at chemistry and wants to improve that, your explanations are fantastic and so engaging and funny. Thanks for all you do!

[@AntimatterBeam8954]

Could my neuroanatomy lecturers at uni have been like this introduction, my lecturer sounded like he hadn't seen modern life before. And tier lists + learning = good PS - thank you for saying biology is complex. :)

[@turbovirgin_]

People say that the human brain is essentially a very advanced computer. If this is true, then deciphering the mechanisms of the brain is like trying to make sense of spaghetti code written by insane hyperintelligent chimpanzees that have drafted, redrafted, overwritten, feature-creeped, and developed one after the other, for six thousand years. And the computer runs in Terraria.

[@dororo2597]

Cerrebelum

[@zhon5311]

love that you're having fun in these videos. thank you

[@That_Chemist]

I am having fun making them :-)

[@thefoxthatplaysgames1543]

22:40 the AMPA receptors description is just the NMPA receptors description Great video

[@gboekenkruger1]

Thank you for the depth to each neurotransmitter. Most information videos are so basic, you covered a lot!

[@0alalune0]

I love how much explanation you added about these molecules' functions!

[@princepsregem4006]

Serotonin is by far my favorite of the neurotransmitters. I absolutely love the special liquid colours it can make you see.

[@derenjoy3r]

Damn, that start is pretty high quality. Good explanations!

[@That_Chemist]

I'm glad you like it :)

[@fero_101]

Please make more neurotransmitter videos, your explaining of what they do and how they function is so good, its also really interesting content. Loved the video :).

[@VirusGamingHDGaming]

0:36 little note here, neurons cannonically only release 1 NT. Some exceptions like motor neurons exist but 2 is usually the max. However, a neuron can accept different multiple neurons based on the receptors on its dendrites.

[@shakogasteier6370]

No they Release all Kinds at any time, sometimes in a pulsating manner, or in a more steady Stream called Tonic. For example Tonic Inhibition via gaba IS very important in the brain. Tonic Inhibition IS modulated also via glia cells... and some antiepileptics decrease gaba decarboxylation...

[@shakogasteier6370]

Sorry they increase glutamate decarboxylation, which increases gaba...

[@Drunk_scientist201]

I love you and your videos especially those about biochemistry, I swear to god u directly hit a spot with your animations and explanations of the biochemistry. I could literally listen to a whole semester of biochemistry in a week if it was all videos of yours

[@nagoshi01]

Man this is amazing. When i asked for a high quality neutrotransmitter video, i didnt expect it to be this good!

[@penumbrium]

love the vid. I was curious if you would involve neuropeptides in the list such as dynorphins, enkephalins and endorphins. the opioid receptors gettin no love today.

[@That_Chemist]

if people are interested in the topic of neurotransmitters, we may consider making more ;) the best way to help is by sharing the video with people who you think would enjoy it!

[@TOP.MUSICZ]

This video's quality is stunning, keep it up and thanks for all the informations ;)

[@That_Chemist]

We're glad you like it :)!

[@nerfnerd10]

Please continue this video series for every neurotransmitter!!

[@RichardBaran]

Wow! You made this so easy to understand. I thought I was mildly versed in this subject. I was wrong. I knew more than most I talk to but looks like nearly nothing when it comes down to it. I often passively watch KZbin, this was so awesome anytime I was distracted (adhd guy), I went back and watched it again. As always awesome work!

[@RichardBaran]

I also deal with GAD, social anxiety, depression, aspergers, ect. I've also experimented with a lot of drugs. So it was really helpful to learn this much data in this short of period of time in such a captivating way about a subject I'm fascinated with.

[@eliasw8084]

Honestly one of the best channels I found in the past months. Sad to see that it not gets the attention it deserves. As much as it hurts to say, maybe more short form content would do a lot

[@That_Chemist]

short-form content isn't financially viable, now that being said, we are making them anyway now lol

[@sIippo]

New favorite channel. Watched you a bit before but you really made a banger with this one. I love pharmacology and I love S3RL. Thank you. Thank you for putting 2 and 2 together and making an educational yet entertaining video. Never stop doing what you're doing!

[@That_Chemist]

Awesome, thank you!

[@_kww_]

This is by far one of the most valuable and educational channels on this platform. Kepp up the amazing work 😊

[@thatguy431]

bro, the editing and animations on this is amazing! nice work!

[@That_Chemist]

Thank you so much 😃 I will share your compliment with the team :)

[@wake6768]

Loved it! Please do more videos about neurotransmitters

[@prufrock1977]

Love the ChubbyEmu reference 😂

[@Guidus125]

Superb comprehensive and easy to follow overview!

[@contomo5710]

there was so much information packed into this video, ill have to get a little stimulated and watch it again before i can reuptake all that information into my neural pathways in a couple of minutes

[@That_Chemist]

I hope your signal transduction is affective :)

[@davidcora2751]

Thank you for a fascinating glimpse into the complexity of life!Very informative as to the basics which is somewhat within my grasp. Love the humor and the Zappa reference 😁😁.

[@That_Chemist]

Glad you enjoyed it!

[@TheStefProff]

wow, this channel is insane i love it. Great job, bro!

[@That_Chemist]

thanks :)

[@Clubcanthandleme13]

the chubbyemu bit got me, had to check if i was still watching a that chemist vid lol. great as always, as someone who's got an interest and chemistry, especially how things react with neurotransmitters and medication with the body as a whole, this video taught me a lot more than text books could in such a short time

[@That_Chemist]

I will share your kind words with the team :)

[@whitlermountain7198]

I love how much fun you have with this video

[@nina-mill]

Jesus Christ... I just spent over three hours watching, pausing, digesting, and resuming a 30-minute KZbin video about six neurotransmitters. This was so dense, probably the most well compressed info-packed KZbin video I've ever watched. How did you do it! The writing, the editing, the animations, the research (that long ass list of references in the desc!)... and the humor sprinkled along the way💛 I couldn't be happier, I feel so immensely lucky to have this available to me- and for free? Incredible, incredible work from everybody involved, oh my goodness! Thank you all, from the bottom of my heart!Bless you!👏👏👏🙏❤️‍🔥🔥🔥💯

[@That_Chemist]

I'm glad you enjoyed it a lot! The best way to help the channel is to share the video with specific people who you think would enjoy it :) Have a _great_ day

[@Some_Tomfoolery]

Let’s goooooo, another video from thatchemist !!!🥳 This video is very stimulating, keep up the good work!

[@That_Chemist]

Thank you very much! Based and grimace-pilled

[@Some_Tomfoolery]

You are based :D

[@1.4142]

Crazy how tiktok got inspiration from this channel's injoke.

[@joranlefleur7942]

'Weeeelcome back, I'm that Chemist...' Such a great way to open your videos, love it. And the tier rankings of chemicals always crack me up!

[@markos.5539]

bro this is probably the most amount of actual learning ive gotten in a while and you made a 30 min video of it. Props to you. Still have to pause a lot to even grasp wtf is going on. It is definitely interesting and i wish to know more.

[@That_Chemist]

I appreciate your kind words! It motivates the team to keep making videos :D

[@3DRiley_]

Yes! I've been thinking of that S3RL song the whole time you were talking about Dopamine, love it!

[@rodrigonamescobedogarcia8629]

Awesome videoooo, love it

[@That_Chemist]

Glad you liked it!!

[@DubbyMoodz]

Ever since I subscribed to Hamilton Morris I keep getting recommended these type of videos. Thank you Allmighty Algorithm for bringing me here, this video is incredibly concise for the amount of information it has.Alos, that quick humor works really well. :)

[@That_Chemist]

We also did a podcast together ;) kzbin.info/www/bejne/mqWqfqyBoa-bm7s

[@Doc_Vic]

Loved it. Make a part II !!!!

[@hikarok4055]

Great video to explain the basic principle of how neurotransmitters work. Especially valuable for me and my friends (already shared), who just can't understand what I am talking about sometimes :^)

[@That_Chemist]

you are a legend for sharing it :)

[@ColinTimmins]

Fantastic video. I had to slow it down by only 75% of the video speed and paused the video 50 times but I got there an hour or so later. But I learned a lot. Thanks! =]

[@adamantris2]

that tiny music video at the end imitating the actual dopamine video by s3rl caught me offguard, love it

[@ashton4537]

I literally have to comment on this video just to say how amazing the research for this is. The research you put together on mental health disorders and how different receptors are linked to them was not something I was expecting to find but as someone who used to take anti-depressants it was extremely interesting learning more about the different serotonin subtypes. I remember memorising the serotonin 5HT2C receptor when I was 14 as it is a common receptor site for SSRIS and it was something that intrigued me greatly. This video is incredible (especially as a highschool chem student), and I'd love to see more on the chemistry behind mental health disorders or even the endocannabinoid system in future :)

[@That_Chemist]

Our next big video is one on ADHD :)

[@ashton4537]

​@@That_Chemist Absolutely awesome.

[@NotreDanish]

Well now I understand even better why I am taking the specific medication I just got prescribed. It’s an NDRI and it was recommended due to me having depressive mood swings and ADHD symptoms and now I understand even better why it works well for both parts.

[@GerinoMorn]

Learned helplessness is such an important topic, I think one of the most shocking I took out of my psych studies. I didn't graduate so I'm not gonna offer any advice to anyone, but do check it out, if you have.... troubled past.

[@ciwous3759]

Be careful with the judgements you give, but don't get overcautious. It's good to share those thoughts.

[@AirwayBreathingChair]

This brings back memories from the pharmacology classes I had to take for CRNA school. Would love to see a tier list of anesthetic drugs 🙂

[@reallightfield5314]

What I've learned from this is that apparently everything can cause Anxiety if your body is screwed up enough

[@BigDaddyBostin]

Omg good info thanks homie

[@That_Chemist]

no worries broski - I gotchu

[@mattgraves3709]

Subbed. Outstanding!

[@That_Chemist]

Welcome aboard - I hope you enjoy :)

[@0xmmn]

I've never seen a youtube channel that goes this deep on any topic. thank you for doing this tho!

[@andrewz2854]

“I like to think of GTP as the Canadian dollar of the cell.” Perfect

[@vladthe_cat]

Its funny how the brain is learning how it works lol

[@PrestonThePianist]

I guess me taking Biochemistry really paid off. This is such an amazing video covering so many hyper-complex concepts in amazing detail and clarity! Can't wait for the next video.

[@That_Chemist]

Glad you enjoyed it!

[@chemdelic]

Editing is insane bro

[@That_Chemist]

thanks! David is a king

[@MySuperhappyfuntime]

Lazy Sunday with a new That Chemist video 😊

[@euchiron]

The Enterochromaffin Man? Who lives on Duodenum Lane? Squirrel moment: I loved hearing especially about norepinephrine and serotonin because I take Effexor/venlafaxine, which inhibits reuptake of these two. Love this stuff!

[@andrewwheat8939]

we want more like this! you're amazing!

[@That_Chemist]

it's only possible with the amazing team we have :)

[@rietbergamber852]

I have been studying psychology and neuroscience for 5 years and failed the learning and memory course 3 times. This video taught me more than that entire course ever did.

[@That_Chemist]

I’m happy to hear that it helped! It sounds like the prof for that course needs to work on communication

[@rdallas81]

​@@That_Chemistor- someone needs to study.

[@salvadorbarbagarcia7907]

this guy is nailing the design of his videos even further

[@GerinoMorn]

Ah yes, noradrenaline. It turns out that when treated with serotonin/noradrenaline reuptake inhibitor my heart rate rises from my "normal" 36bpm to something more traditional xD

[@madisonking8057]

Excellent video sir 👌!

[@That_Chemist]

Glad you liked it!

[@madisonking8057]

@@That_Chemist I will say I had commented this after the first portion before you got into the tierlist, and as an avid glycine fan I'm going to have to downgrade you from excellent to just very very good.

[@anotherone4669]

Amazing video

[@That_Chemist]

Thanks!

[@heyihavenoclue7541]

your videos are very inspiring and interesting, thank you :)

[@That_Chemist]

that is very kind of you to say :D

[@ujfujf422]

Before watching this i randomly thought of your channel and this is probably the topic im most interested in by a mile. thank for making this vid, popped up at the perfect time too was researching them. watched ur channel a lot. (I have no formal knowlege of biology and biochem (no real education on it lmao dropped out of UK fucking hichischool lmao) but i've learnt a lot

[@That_Chemist]

glad to hear it!

[@ujfujf422]

really well put together video too must i add

[@lunareclipse363]

Finally, an interesting way to learn the things I missed by not going to neurochemistry lectures in uni and barely passing the course as a consequence!

[@Ch0ckl8]

Very dope. Though I was kinda hoping for a link between GABA and canabioids

[@AnthonyBolognese710]

12:05 great video. There’s one additional aspect I believe should be mentioned about the dephosphorylation of the GTP. That phosphoryl group is transferred somewhere. Kinases add it to certain amino acids iirc so I’m wondering where it went in this demonstration. I’m guessing it was added elsewhere to the subunit that binds to GDP, or one of the other two as a signal to get into position. Phosphorylation events are part of the signal cascade too so I wasn’t sure if I missed it or it wasn’t covered in this part.

[@That_Chemist]

We didn’t cover it - one of the subunits is transiently phosphorylated so that it can carry out it’s function

[@AnthonyBolognese710]

⁠@@That_Chemistthanks for confirming that. I wasn’t sure if I missed it. I knew it had to go somewhere.

[@mdotnk]

Never subbed so fast at the chubbyemu ref now I have to binge this whole channel and I’m not mad. More dopamine for me

[@applenrd]

bro is going from orgo memes and peer review comedy to an MCAT study channel

[@zizkovhoodmoments1590]

Amazing video, you should do a part 2 about more stuff like enkephalines, endocannabinoids, vasopresin etc..

[@That_Chemist]

Thanks! We may do specific videos about more neurotransmitters in the future

[@zizkovhoodmoments1590]

@@That_Chemist especially vasopresin it's signaling pathway is now explored for it's role in pair-bonding behavior and involvement in sexuality

[@dororo2597]

​@@zizkovhoodmoments1590what did you mean by pair bonding in this case?

[@jules-sf5us]

coming back to this video a few weeks later. i freaking love neurotransmitters. i really like psychology and i like this channel (even though i know little to nothing about chemistry) so this video really caught my eye

[@That_Chemist]

awesome :)

[@loganwolv3393]

I can confidently say that this video has decreased my GABA levels and increased my Dopamine, Serotonin, Acetylcholine, Noradrelanine, Serotonin and Dopamine levels all at once! Thank you.

[@carelessanonymous6570]

Another banger video as always, keep up the fantasic content

[@That_Chemist]

Thank you :)

[@karinamariapiotrowska5505]

This is so fun! Thank you :)

[@That_Chemist]

Glad you enjoyed it! :)

[@folkereicht5746]

great content!

[@That_Chemist]

thank you :)

[@luke144]

Thank you!

[@That_Chemist]

Thank you for watching :)

[@End0morphin]

Please do an addendum regarding endogenous morphine relevant to tyrosine/Ldopa production and any thoughts on endogenous morphine production in respect to parkinsons and the precursor/intermediate isoquinoline reticuline

[@sebastian5671]

have a biology exam tomorrow and im procrastinating, thanks for the GPCR explanation, really good

[@That_Chemist]

Glad it helped!

[@LifeofQualia]

Amazing thank you

[@matt566]

something i legit dont understand about human bio is like how in the world is neurotransmission so insanely fast? like the diagrams make it seem like the synapse vesicles move to edge then release then the receptors receive then it decides if thats gonna continue. like okay fast transport is like mm per day okay… but you touch something and you feel it cia registering in brain in literally 50ms??? how does the math work out here?

[@Exergonick]

So that's a good point, there is a pool of vesicles ready for release and it kind of rotates them in and out kind of like an airport, theres always something on standby. My explanation was more focused on how they show up in the first place not how they are released, but effectively there is a voltage gradient that runs down and triggers them faster than any protein process.

[@rilmar2137]

So many neurotransmitters to pick from and yet my brain just decided "no, thank you"

[@That_Chemist]

Sometimes you gotta help them get fixed

[@k.mankeiru8359]

Now i need a cocktail of these

[@bubatsuckt]

I see you put quite some effort in the visuals, but I think the receptor protein blobs all from different angles and the weird color coding on the transmitter molecules are more confusing than helpful. apart from that you did a good job of summarizing the topic

[@AI.mposter]

I like this, more neuropharmacology please dude