The 6 Worst Drugs In Videogames

[@sheepchemical3024]

Winners don't do drugs, except for all of your favorite video game heroes, and most of your real life heroes

[@melikecomedy]

Bwahahahah. This is so true

[@migueeeelet]

+Michelle Dawson amusingly they usually go down after doing drugs.

[@KrispyKPL]

Remember. Stay in drugs, don't do school. ( ͡° ͜ʖ ͡°)

[@MyVanir]

+Am I one of the cool kids yet? You aren't.

[@migueeeelet]

+Am I one of the cool kids yet? You think you're hot, guess what, you're not. The over use of lenny faces are taking it's meaning away, soon it'll just be a annoying icon.

[@MyVanir]

migueeeelet I'd say it already kinda is.

[@migueeeelet]

MyVanir It's what happens. People make a "cool" meme and all the kids who want to be cool overuse it to the point it's not cool anymore.

[@12344deathman]

+Am I one of the cool kids yet? No no no, you're doing it all wrong. Stay in vegtables, eat your drugs, and don't do school.

[@mr.s9783]

ADAM anyone?! It's literally the worst drug ever!

[@RobbieGoldy]

Ah, but it is effective and quality guaranteed. Evolve today!

[@mr.s9783]

Andrew Ryan​ Don't you have a golf club you should be removing from your skull?

[@RobbieGoldy]

It's just a flesh wound.

[@mr.s9783]

Yes, and a rather serious one at that. You should have Suchong look after it... Oh wait.

[@MultiHydralisk]

Iron Tager Yes. Much to our dissapointment, the good doctor has checked out. *smashes open a first aid station*

[@abdullahtshabal373]

"Winners don;t use drugs, but since you lost, go for it!" - Pico vs. Uberkids (Newgrounds)

[@TheRealMEEDABEE]

Why does it look like Mike is on just about every drug in this video?

[@AlphaSquadronAintSloppy]

I was wondering the exact same thing

[@mikeemmons1079]

I just want to know which one made him think popping his collar was a good idea.

[@chillmadude]

I can only assume they purposefully made him look like that as some kinda joke

[@mikeemmons1079]

chillmadude it worked.

[@taylorh1872]

Well they had to have SOMEONE test them out so they can put them on the list.

[@Kovugamez]

Joker keeps his intelligence because titan makes you go insane, and he's ALREADY insane

[@AgentJTV]

I know Jet is on the list but UltraJet is far worse. Although UltraJet isn't as easy to get addicted to, but once you DO get addicted to it, it's permanent. WARNING: Always save before taking UltraJet, kids. It just may save your save file.

[@dmas7749]

Joshua Berger Yeah, the chances seem kinda bullshit. The same character can take something once and have an instant addiction, on the other side of the spectrum he can down 30 at once and go on just fine.

[@Ibarakify]

Joshua Berger Disagree. Psycho is a much more powerful and addictive drug that inevitably results in actual psychosis/psychotic breaks. Aggression is inherent upon taking it, as it's a botched military combat stim.

[@theavatar4668]

BLU Pyro I'd say the worst is Stealth Boy? I don't know if it counts really but it definitely has some pretty nasty effects!

[@Ibarakify]

The Avatar I forgot all about that! Repeated exposure causes severe schizophrenia which is closely related to psychosis in certain aspects. Not sure if it qualifies as a drug, but it's addictive for sure judging by the Nightkin.

[@TheMohawkNinja]

Joshua Berger Talk about a clean save...

[@anthonyfiordaliso5689]

Not even an honorable mention to ADAM from the Bioshock series? It caused a city to go insane.

[@dragan4693]

your right!

[@punpun4839]

Remember, kids: Stay in school, don't do drugs, eat your teeth.

[@projectpems8304]

Why is ADAM from Bioshock not on this list? Have you seen the shit it did to Rapture and it's inhabitants? Everything is fucked because of it!

[@sanfrandartgun6614]

i agree that should be like #2

[@MAXHALO369]

ADAM isn't really a drug though its a genetic material that alters the users DNA.

[@danielwood6553]

Wouldn't the same be said for the Titan serum though? And I suppose Eve would be the drug

[@MunchKING]

You left out that if you give Jet to people with heart conditions in Fallout, they can literally have a heart attack and die in front of you.

[@iimuffinsaur]

tell me who to give it to ;)

[@MunchKING]

I dunno, I haven't played 1 or 2 In a long time...

[@arduousJester]

That was John Cassidy from Fallout 2, but he's a special case. He, and later his daughter Cass in Fallout New Vegas, have a really unfortunate heart condition and are incapable of taking any drugs without dying. Also, Cass' personal mission and one of the possible two perks you get for completing it are jokes about her heart

[@sarahmcfadden8990]

boy o boy....yes I did knowingly click on an Outside XBox video but missed the part where it was posted 7 years ago. I was jolted by the production quality. You guys have much much improved over the years! Everybody appears more comfortable in front of the camera now too lol.

[@CountXelles]

Not a single mention of Plasmids from Bioshock? That shit will give you more than just cancer.

[@devinthierault]

Not a drug, but those virtual trips in Watch_Dogs are wacky.

[@ethanarmishaw1633]

Man. The spider tank digital trip rocks! Am I right?!

[@uwotm835]

Goddamn answer the man! was he right?!?

[@marcelob.678]

ethan armishaw is the best one

[@bigcorydawg3661]

Back when outsidexbox didnt have their chair

[@awake1251]

Hahaha holy shit the last joke about the frying pan being heroin was spot on, gotta love it

[@CelticVictory]

It was actually the frying pan smashing the egg that was your brain on heroin.

[@SamM6599]

What about the Sons of Samedi's Loa Dust in Saint's Row 2? That REALLY messes with the player character. Sure it can't kill you, but it blurs the screen like crazy, making it a bit hard to see the bad guys. I usually fail between 2-3 times before finishing the level.

[@TheStrangr]

As Oblivion goes, I'd go with Hist Tree Sap. It caused you pass out and, when you eventually woke up, hallucinate that civilians were goblins and ruthlessly exterminate them. It was only used in one quest, but it still deserves a mention.

[@treemasterbob]

what about valkyre from max payne, that shit drove any who tried it off the deep end.

[@martinvurbanov5335]

"We've never tried magic mushrooms", that grin when ya said it tho

[@KimStennabbCaesar]

I would have liked to see the sequence in the first Max Payne game where the thugs drug him, that's like the definition of a bad trip really.

[@kbolternorris2676]

I can't belive I forgot that, you got a point sir

[@ham4fun]

i was waiting for them to mention that one too.

[@davidmurray3542]

The drug in Max Payne was called Valkyr, btw

[@crystaljones1935]

"Spanked up lunatic" is now my new go-to insult.

[@regiman222]

What about Red Sand from Mass Effect series? Is it not on it because you can't take it yourself?

[@The69DJ]

I always wished there was a video game where like the objective is to go around and consume as many drugs as you can. And like the objective is to OD but as you take more psychoactive substances the controls and visual become increasingly disorientated. especially with VR gaining steam, that could insane fun!

[@Catclaw01]

I'm surprised they didn't even mention Valkyr from Max Payne.

[@LtBasil]

One about that one biotic-enhancing drug from Mass Effect 2? You know, the one that slowly kills you and makes volus think that they're "biotic gods"?

[@venuspiano2303]

Red sand?

[@kriggitch.5855]

Drug of choice: fuzzy. Man, one touch and you'll get so dizzy.

[@Smegle125]

The whole video was chuckle worthy, but the final joke about the frying pan made me lose it.

[@lancerd4934]

No red lyrium?

[@IshidaNikurasu]

Wouldn't call it a drug to be honest.. Closer to black magic? 🙄

[@EskimoPagan]

Or lyrium in general, really

[@theoneandonlymichaelmccormick]

What about Valkyr from Max Payne? That's one BAAAAAAD trip!

[@ImWeirdAndILikeIt]

No one's gonna mention Adam from Bioshock? The withdrawal effects caused almost an entire city to turn into batshit junkie zombies

[@SegGel2009]

0:47 They make House of the Dead 4 t-shirts?

[@lusteraliaszero]

Skooma is the equivalent of morphine, not crystal meth (moonsugar is). Down to having dens.

[@callumkingunderwood]

there are dens of meth users too

[@lusteraliaszero]

SixSixSevenSeven that may be, but they're hardly as iconic, and everything that surrounds the drug is a massive opium reference. There's no fucking doubt about this

[@DarthShadow25]

lusteraliaszero So are you arguing that it is like morphine or an opioid? Because you are arguing for both. Also it is basically drinkable heroin.

[@lusteraliaszero]

DarthShadow25 Yeah, skooma is the equivalent of an opioid. Heroin is pretty much just better opium. But the entire culture surrounding skooma is obviously a reference to opium.

[@ThrottleKitty]

Let someone who knows what he is talking about fill you in. Moon Sugar is basically like Cocaine, but it is consumed orally, has a very sweet taste, and it also has powerful magical properties, allowing you to cast more spells and faster, as well as heightening the senses. On it's own, it is not very toxic, but in high doses it can be lethal. Moon Sugar is mildly addictive. Nightshade is basically like Opium, it is a powerful muscle numbing toxin. It is very lethal in anything but the tiniest of doses, and can cause paralysis, amnesia, and any number of other wonderful brain destroying problems. it is also an intensely addictive substance, causing feverish nightmares in addition to very opiate-like withdrawal symptoms for weeks after a single dose. So you take moon sugar, and mix in a tiny bit of nightshade with a few other "filler" ingredients, and you get Skooma, a drug that gives the drinker a powerful cocaine like high, and an opiate like numbing effect. The withdrawal to skooma is incredibly intense, like a heroin withdrawal, but with an intense lethargy you would get from a speed withdrawal. So yes, Skooma is like Opiate, and Speed/Meth/Cocaine all at the same time. You are both right, and wrong. Also, it is a common misconception that Khajiit like Skooma. They like Moon Sugar, but do still drink Skooma. You'll notice they always have control over their moon sugar enjoyment as well. Dark Elves and Argonians are the ones with the real skooma problem, in almost every TES game there is an argonian and/or dark elf with a serious skooma addiction problem.

[@Hortifox_the_gardener]

Nice that you included Skooma. But you should have mentioned Redwater Skooma - it brings all the nice effects of regular Skooma but is stronger and eventually kills humans :D

[@TheGloriousLobsterEmperor]

Ahhh my home... The magical kingdom of Australia... Where nothing goes untouched... Thanks guys...

[@loneshewolf74]

Because of Mario's terrible mushroom addiction I avoid even the ones at the grocery store. Seriously though, I thought they were going to show Dr. Mario since the whole game is about flipping capsules into a giant jar and killing kind of trippy-looking viruses, lol.

[@collinlampert5493]

ik gta5 wasn't out yet but using the bong isn't bad.... its fun

[@StatikDynamikDubstep]

Except cigarettes slowly kill you when you're playing online, which is hilarious. You can commit suicide by smoking. It's pretty funny.

[@projectpems8304]

lol... gta5 teaches smoking is bad

[@darthcannabris5406]

in metal gear solid if you smoke, your health slowly goes down and otacon warns you about them

[@iareduck6654]

drugs: because life is boring.

[@ParallelUniversity]

The punga fruit trip in Fallout 3 was pretty wild

[@Nimarex]

I'm story but what the fucking hell? Where is Valkyr from Max Payne?

[@Baxten123]

YES.

[@AlexanderGreensmith]

That Manchester reference though.

[@robtoe10]

Stelios78910 What Manchester reference?! I missed it! :O

[@AlexanderGreensmith]

robtoe10 At 4:20 talking about Pac-Man. Not the best reference for the area, its just surreal to hear a group of Southerners acknowleding the North haha.

[@AlexanderGreensmith]

Oh heck yes, I live in the North where it is deemed friendlier but poorer due to all the industrial mill towns being closed down, in the south meanwhile they are richer and have a better quality of life with aside London more historical cities and spa towns. Though countryside is about even around the nation though. Its a huge issue in the UK right now, the governments main conservative voters are predominantly down south so the government will give more money to the south even if they don't need it. But the deprived, often dirty albeit more cultural North needs it more - especially during the recent floods. If you want to be more bored about this topic, hit me up. There's a huge difference its a common joke.

[@CattleDekappa]

+Joseph Batson England is referred to as just England, with England, Scotland, Wales and N. Ireland comprising the UK. Great Britain refers to the 3 excluding N.Ireland. Stelios is mostly spot on, I'm from Manchester and currently live in York. The North typically is a lot more down to earth, with people being friendlier yet ruder if you get me. The south is typically more reserved with people being more 'polite' which i personally am not a fan of. Racism... I don't find that a North/South divide, it's quite even throughout but is far less of a problem than in the US. We don't tend to find outright acts of racism as such, if any it's mostly concealed and condemned by the vast majority of people. We're all more integrated you see, being on a much smaller landmass. In terms of socio-political climates... The North is more a Labour stronghold, the more left-wing party with the South traditionally being more Conservative, the right-wing party though it's not really that even, it's more complex across countries, regions and even counties. Though that is the traditional trend. Wealth wise the South has more money, with far greater government investment down there like Stelios mentioned, greater investment in infrastructure, education, health etc. Though for all of this it is far more complex, we have over 2000 years of history here, nothing's ever simple xD Do ask though if there's anywhere here that is taking your fancy that i can maybe offer some help on

[@gameralfa095]

What about the Triptocaine from Heavy Rain?

[@JeremyRichardsonFTW]

I believe the actual reason he spiraled out of control was from the ARI, and not because of the Triptocaine, which was supposed to be a treatment for the symptoms caused by Norman using it too much. I think, don't quote me on this.

[@sapphicjester]

***** I THOUGHT THE SAME THING

[@lauracomi234]

One of the worst drugs is Adam from Bioshock, you see what it did with the population of Rapture

[@francis6888]

For the "magical land of Australia" I would really like to see a video outlining the ridiculous reasons games have been banned in Australia. There are some real great pearlers out there ending up with some companies finally deciding not to bother with marketing their games in Australia due to the laws.

[@JameZayer]

+Francis Alot of them were for stupid reason, but others did have some 1/2 decent reasons if you take into account that most of our politicians are old farts that are mentally stuck in the 50s. Barely anything gets banned here anymore, but now we're stuck with massive rates of piracy here due to alot of companies putting ridiculous prices for games and music here. Itunes makes us pay double price for absolutely no reason (not a matter of "tax," as rates aren't that high).

[@amansizedduck]

"Valkyr" - Max Payne. really?

[@mr.messofgeorgia]

The "pot" that a guy gives Michael in GTA5 that causes him to think he's being attacked by aliens when in reality he's having a deep conversation about legal barriers around pot

[@FumiTheSillyGirl]

you forgot Valkyr

[@spencergadbois6331]

Is it just me, or do the two guy hosts seem ironically stoned in this video? I dig the dedication.

[@violentinstincts]

what, no max payne ?

[@TheIndieKiddie]

9 years ago, outsidexbox was a emo rock band that loved video games.

[@spikeharusame]

seriously? Loa Dust from Saints Row 2 didn't make it on here?

[@roprope511]

Loa Dust didn't really make a big difference is SR2. It was the main product the Sons of Samedi sold, but apart from a few missions in taking their business, and one being drugged, you can't really say it's one of the few things that pop in your mind automatically after someone mentions Saints Row 2.

[@spikeharusame]

it does for me because that was one of the funniest and coolest moments in the game, considering the boss was able to escape a trap and kill shitloads of Samedi while BAKED out of his skull

[@roprope511]

spikeharusame Okay, I might have disregarded that mission. My excuse is the PC version with its problems in game speed.

[@spikeharusame]

360 version is better, when possible, play the console version of the game, the graphics might not be as good, but framerate and ease of control more than make up for it

[@callumkingunderwood]

spikeharusame control issues are easily answered with a gamepad.

[@callumkingunderwood]

Skooma was always rather hilarious, downing a tonne of it in oblivion was always an easy way to max out your speed. The worst one in any video game has to be the green needle in Surgeon Simulator, still, I got an A++ on ambulance brain surgery while high on that so its not all bad :P

[@wheelman1324]

Valkyr from Max Payne?

[@kriskw1288]

Mother 3's 'shrooms are also pretty unsettling after they put poor Lucas on a bad trip. Normally, the thought of a child using hallucinogens is bad enough, but you really start to get a feel for the intense emotional trauma Lucas has been through. Through his hallucination you start to see how he sort of blames himself for the death of his mother, disappearance of his brother and he questions whether or not his father still loves him. You also see that he swims in toxic waste by mistake :P

[@frasercrawford1]

what about sleeping tree sap in sky rim, way cooler than skooma.

[@DarthShadow25]

Hist sap is worse.

[@frasercrawford1]

DarthShadow25 true cause goblins aren't sheep

[@xKiuuu]

Imagine taking drugs, and all of the sudden a message appears in front of your face saying: "You are now addicted to drugs."

[@afrosponge1]

And thats why you smoke weed kids :)

[@billyc2010]

I grow to like this channel more and more each day.

[@reptilepope6454]

Magic mushrooms are awesome! If everyone tried it atleast once in their life there would be no more wars. I reccomend Copelandia Cyanescens.

[@GuitarGasmProduction]

it is so funny how this is coming from someone called the reptile pope lmao

[@reptilepope6454]

why is that?

[@Snappingeel67]

Heroin should be given to kids once they turn 5. That way they can choose at a young age if drugs are for them or not. There would be less crime

[@MrIpodtouchey]

my fucking nigga, people think shrooms are just fucking crazy and you hallucinate and shit, while you can get this fucked, an average shroom trip makes your walls breathe, see patterns in shit etc...

[@projectpems8304]

Try the cordyceps fungus, your eyes will open to a new master (it actually causes you to lose your will and psychologically go around spreading fhe fungus)

[@mr.jinjie3749]

Back then Mike looked like he did drugs

[@CineRage]

Um...what about the V drug from Max Payne?

[@zerodollarbird]

Valkyr? Yeah, point there.

[@OtakuMan05]

Don't forget ADAM from the Bioshock series. Doing that shit can actually mutate your body in horrifying and unspeakable ways. Not to mention the fact that as it's mutating your body, it's reducing your sanity to that of a psychotic killer on par with Charles Manson.

[@howabout24]

Drugs are terrible in fallout, they don't help you very much, and fuck up your character, I've never found a good use for them, same with alcohol.

[@sadochrist8534]

They are good to sell at traders as you often end up with so many of them.

[@joes.6448]

- But its SO worth taking them just to hear a doctor call you a damn junkie. Plus, I like my characters to experience what I'm experiencing. Slam some Med-X just for the fuck of it yo!

[@Pile_of_carbon]

Actually, you can do some hilarious stuff with psycho and med-x. I stormed Evergreen Mills in only dressed only in boxers and a powerfist. After clearing the outer area, I went toe to toe with the behemoth they keep there. xD In pretty much all other instances, drug use in the Fallout games is a terrible idea and only good for self-imposed hard mode and selling to merchants.

[@DarthShadow25]

Med-x buffout and psycho are all pretty helpful, but the others are useless.

[@itsrlycold]

What about Valkyr from the first 2 Max Payne games?

[@420BudNuggets]

drugs are bad hmmm k

[@devintaylor440]

hehe... we know how that turned out..

[@jafethramirez1420]

No they're not

[@stevie2889]

Lol coming from 420BudNuggets. Died when i saw your username

[@H8Magnet]

Lullz, you guys are stoned!!! Who's idea was that, it's hilarious!!!!

[@vincentjpk]

lol. skooma

[@krampusklaws2238]

Magic mushrooms are amazing, but you have to take them in the right set and setting, or you're gonna have a bad time.

[@epicSheep-ek5yl]

The Far Cry 3 scene is so weird... you go to climb up a vine and halfway up gravity turns sideways and you're walking up what used to be a wall...

[@katfromthekong414]

Oh goodness.....look at you guys back then! 😂❤

[@rocketeergamer4444]

I know GTA5 wasn't made yet but I think the drugs Jimmy gives to his dad are pretty....Interesting

[@AquaHedgehog]

How about "Joy" in LISA the Painful RPG and the Joyful sequel DLC? In-game it gives a hefty combat stat buff with a withdrawal that makes addicts near useless in combat. There's also the fact that it literally makes you feel nothing at all - physically and mentally, it causes you to be completely consumed by your deepest desires, and overdosing causes terrifying fleshy hallucinations and gradually causes you to mutate horrifically.

[@EliteKhajiit]

Good memories playing Shivering Isles. Bad, BAD memories of Felldew. Sheogorath is one of my favorite Elder Scrolls characters. "I'm so happy I could just tear out your intestines and strangle you with them!"

[@toasterqueer]

Whatever the Son took in the end of Hotline Miami 2. That was some heavy shit.

[@kryskiller666]

So, what about Persona 3? One of the characters, Shinjiro Aragaki, lost control of his "persona" (some sort of Summon, from within your soul and personality), and accidentally killed an inocent woman. Since that day, he started taking some weird kind of drugs: Strong enough to make him be able to control his own mind, and so use his Persona again. Infact, the drug is so strong, that it's slowly killing him from the inside. **Spoiler** Ironically, he ends up dying defending the son of the woman he accidentally killed, who ment to kill him on the first place.

[@Thrythlind]

and apparently if you were exposed to the Joker's titan-infected blood you start turning into the Joker

[@davidpozzie3881]

I couldn't be more disappointed. Seriously, no one mentions ANY BIOSHOCK GAMES!?!?!?!?! Are you kidding me!?!?!?!

[@VanillaLoaf]

true, it needs more people like you who get angry with people over the internet for no reason.

[@camazotzz]

tenenbaum quote "ADAM acts like a benign cancer, destroying native cells and replacing them with unstable stem versions. While this very instability is what gives it its amazing properties, it is also what causes the cosmetic and mental damage. You need more and more ADAM just to keep back the tide. From a medical standpoint, this is catastrophic. From a business standpoint, well... Fontaine sees the possibilities."

[@CelticVictory]

That is my favorite drug PSA.

[@AresSG]

Can we not forget MGS4? I know it was some mixture of adrenaline and nano-machines but basically Snake kept injecting himself with steroids to keep going on. He literally couldn't go on without it, hell in the final fight both him and Liquid even inject eachother.

[@freedomsky100]

My first thought as well, and after three uses is liable to cause death from bleeding out of your eyes. Or something like that.

[@freakboy186]

What about the Terran marines in Star Craft? They can take a stimpack that boosts stats temporarily at the cost of some hp.

[@thatyoutubeguy2181]

Why is Atom from the Bioshock series not on here?

[@SohiTheTinyKittenHuman]

Oh Mike you look like you’re an addict in this. I say this with love! I’m so glad you look so much more put together now!

[@bsullivan0409]

What about lyrium from Dragon Age? I've only played the first game, but that's more than enough to see some of the awful side effects of using it, not to mention the fact that it can get you wrapped around the chantry's finger, so says Alistair. I haven't, however, played as a mage, so I'm not sure if lyrium affects the player as much as it does the NPCs, or if the effects take longer to muster than I had originally thought.

[@Orangina387]

+bsullivan0409 Lyrium actually never affects the PC. The story is that mages can recover from having a "mana imbalance" caused by imbibing processed lyrium, and if they do it safely nothing should go wrong. It's people without magic (like Templars, who seem to take it like a steroid) who can become addicted and suffer adverse affects. But the game doesn't let you take lyrium potions if you're not a mage (at least from what I remember, although now that I think on it I'm not sure I ever tried), so there's no way for it to affect the player at all. All the PCs also seem strangely resistant to "red lyrium" they incredibly dangerous strain that shows up in DA2/DAI. That stuff you just have to TOUCH to become addicted.

[@swallowfox237]

Let's not forget Skyrim's imfamous but not well known sleeping tree sap, take that to ad 100 health to you for a minute or so, but it makes you extremely slow and your vison goes all wonky. I actually take it just because it looks so cool, like being on weed.

[@spencerjohnson4468]

what about atom from bioshock 1 and 2 if you can consider it one

[@seanoneil9770]

actually in farcry 3 when jason gets high in the cave that is from the shroom dust that picks up in the air, the pills actually put him in a state of mind of when he was in a night club right before the begining of the game

[@davidcoquillon3695]

Red sand from Mass Effect was pretty bad. Though Shepard couldn't take any, it seemed like a huge problem anyway

[@supervegito2277]

2:40 didnt joker stay as the joker cause he was already insane to begin with? Thats the argument i heard.

[@EthelredFlametail]

Skooma why do I find the stuff. Is there a building with resapice on how to make it accompened by the stuff because I really want to try the stuff. Also would not mined the Shroom down grade in DOOM just tell me where I can find them;)

[@camazotzz]

what is the technical difference between a poison and a psychoactive?

[@mbliss9360]

But what about the glow stuff from Final Fight Streetwise?

[@kevinchari4860]

What about fisstech from the witcher?

[@patmos09]

Uncharted 3's simple trip sequence was vomit inducing.

[@trevorphillips9542]

Once in Fallout 3 I remember I was high on jet,buffout,med x, mentats, psycho and drunk on whisky, scotch, beer, vodka and wine all at the same time.

[@derGhebbet]

You should've added Superadine from CoH...highly addictive and slowly turns the user into a dumb green monster.

[@summerfelix3564]

It isn't from a video game, but there's a drug in the anime "Code Geass" called Refrain that causes you to think that you're living in the past, permanently. It makes an appearance when you see Karen's mother use it, and Lelouch was debating on whether to use it or not, I think.

[@otakucode]

No mention of the drug (forget its name) from Max Payne 2 that gives you a hallucination of tight-rope walking on a trail of blood in the dark while hearing your dead baby crying incessantly?