The BEST & WORST supplements that SLOW aging. Why some supplements are pointless.

[@stephanygates6491]

I take TMG for liver health and digestion. Collagen is not only for skin but fascia, a much larger organ. Decline in fascia has huge implications for how you good feel as you move. My collagen is 7 grams/ scoop. Mixes into any drink.

[@frankasafscimone3920]

NMN is phenomenal.

[@fbomb7184]

Creatine Omega 3 Vit D3/K2 (taken in the morning) Probiotic NAC (taken with glycine for longevity) Trimethylglycine (TMG) only gave a 5, unlikely to be deficient unless you have a “methylation problem” Turmeric but reccomends Curcumin as opposed to turmeric. NMN and she poo-poo’d it 🫢 and here is where I had to go 19:49

[@nicedoppy2077]

Wonderful!!.....u express yourself as a doctor, maybe r u right?!! Thank U for your so relevant great Comment!

[@ForeverSovereign]

thank you!

[@dianelewis3654]

Thanks for the list!

[@Unique_Monk]

12 studies debunk NMN - she’s right - it’s another scam from Sinclair - trials on mice and they claim it’s a miracle pill

[@debracappiccille6485]

I take NAC with Glycine for lung health and the glycine also helps with type 2 diabetes.

[@ronaldbohan2720]

Turmeric has helped people I know .with pepper and without. Pepper to bring down swelling in the body I use it all the time it helps me . Our teaspoon with a sprinkle of pepper in 8 ounces of water. My pain is reduced greatly within 30 minutes.

[@chantalclaeys9624]

Piperine is toxic if you take it everyday! I don’t know if pepper has the same effect. Tumeric is great especially flexofytol forte. Lots of clinical studies are done with this product.

[@kimgayler1478]

Tumeric has transformed my life by alleviating knee pain.I was skeptical but am converted

[@unicorndiva1357]

Same

[@truckmountgirl]

Turmeric/cur umin causes my liver values to skyrocket. So does Lion's Mane.

[@rhombifer566]

I don't think she's 100% right on the turmeric thing I've heard a lot of scientists say that you're better to take it with the turmeric instead of separating the two ingredients just take the black pepper with it

[@ilonabaier6042]

I wish she had given the dosage sizes of the supplements discussed. Thsi is very important.

[@BoStanfordify]

LOVE her! In a sea of confusion she is so clear and well informed.

[@Kathleenschweiker]

Knowing what genes including SNPS you have makes all the difference. If a clinician doesn’t know what genes are active, then they are guessing. Knowing the status of the gut microbiome, methylation, detoxification, toxic exposures, mineral, vitamin deficiencies, the ability to use food,-- are for starters, essential to individualized, precision health care.

[@JasmineSinclair-i3n]

The major mistake people make when choosing supplements is bias. We categorize what we consume into pharmaceuticals (greatest bad), food (much is bad), and supplements (vitamins, minerals, etc) as the least bad. Think of any substance as potentially good or bad. So supplements can be as harmful to you as some prescription drugs. But people will hear about a supplement, buy it over the counter, and take it without knowing of its potential harms. Don't take any supplement unless you know its potential side effects, long-term effects, and interactions. And if it isn't proven scientifically to provide the benefits you expect, or there are contradictory studies, don't take it. The only supplements I take after spending thirty years researching them: 1. Multiple Vitamin 2. Omega 3 3. Vitamin D3/K2 as MK-7 4. Magnesium 5. Fiber 6. Electrolyte powder to mix with water when excercising. Also, if you are either consuming processed food, or food with added sugar, why are you bothering to take supplements? How are they going to make you healthier when you are poisoning yourself with food?

[@AbundantlyNika]

Any particular brands that you like?

[@AshisLydia]

Please dear, could you name good brands please? That will be appreciated.

[@Daryl-l3x]

There are no recorded cases of death from taking vitamins

[@chormelcivil3772]

These are doctors being paid by pharma/supplement industry....you can never compare the benefits of taking real/natural foods to supplements made by lab...

[@Imasoulkind]

​@@AshisLydia For Multivitamin Dr. Brad Stanfield (MicroVitamin) Omega 3s: Swisse Wild Fish Oil Magnesium: Now Foods Magnesium Powder

[@quatropontoum]

I liked the guidance to take Vitamin D in the morning, I started doing this and I am sleeping better than when I took this vitamin at night. Thank you very much

[@BillFlavell]

Dr Nichola correctly warned that many supplements lack evidence from clinical trials but then I wonder why Tim did not ask what trials Nichola's own supplement has undergone.

[@pranaorganics893]

She was on Asprey & was tlkn bout trial .. but idk or really care I wouldn’t take what I already take for much less

[@Daniel-hh8od]

I was surprised that Taurine was not mentioned at all.

[@Dr.Wombat3000]

This video is frustratingly vague! The name of her supplement or even the ingredients aren’t mentioned at all. It’s really disappointing.

[@douglasmillar7560]

My understanding is they have demonstrated an increase in NAD levels. However I'm not aware of any evidence of functional improvement. Ultimately then it is still a hypothesis that the mechanisms used to increase NAD are have a net positive effect when considering their full impact. For example if NAD is being consumed due to accumulation of damage being repaired as we age then increasing NAD by blocking pathways where NAD is required may have the opposite of the desired effect. Additionally these ingredients have other affects. Rutin for example is cytotoxic and is being explored as an anti cancer substance. I'm yet to come across a cancer med without side effects and I've evaluated many as part of my job

[@mattiodowd3209]

So what s her supplement called they didn't promote it

[@susymay7831]

Timestamps would help your nice videos ❤

[@sgtaneja]

Btw, How do you measure longevity gains in short-term trials ?? My pick : 1. GlyNac 2. NMN 3. Rutin 4. Methyl B+ 5. K-Mag (potassium+magnesium)

[@chormelcivil3772]

@@sgtaneja thats the question they cannot answer, because people who have the longest life recorded were the ones eating real foods/natural foods, its proven for years since man was born...never by taking so called longevity supplements, because they are mostly drugs for medicinal purposes only, and not to be taken regularly , the long term effect is damaging.....

[@EduardoMartinez-ys6fb]

Currently I take 10g of collagen with Orange juice (vit C) primarily for tendon health. Biotin together with 10:1 ratio Zinc,Copper for skin health, Saw Palmetto for prostrate health and reduced hair loss. I'm 62 and have exercised most days, all my life.

[@pohaa]

Investigate boron for prostate health.

[@pramuanchutham7355]

​@@pohaaBoron supresses the effect of IGF-1,thereby suppressing prostate cancer...i read.

[@pramuanchutham7355]

Try takng 30mg Zinc Glycinate daily, to prevent enlarged prostate (BPH) and Prostate cancer . I've taking zinc since age 41 and now at 67 without prostate issue (My PSA is right in the middle of the range).

[@gracewygal1423]

Get rid of the sugary orange juice !

[@jennysiepka9900]

S Boulaardi.. great for those who struggle with candidiasis. Also, liposomal glutathione is an option for grreater bioavalability. Also, I use a very powerful red light bed. I use nitric oxide Strips and I test before and after. huge elevation in Is nitric ox after ten minutes in the red light.. Now I don't know how accurate these strips are.But I will tell you that the color changes dramatically... And then I will test half an hour later and it is back down to baseline...

[@paularand8783]

I take collagen pep and if I stop for about a week my joint pains return then I have to start taking it again therefore I give it a 9 out of 10

[@gokarnasargod6366]

Llllllllllllll

[@11kwright]

Pray tell which one you take please. It’s good to have a legitimate reviewer inform whether it works.

[@vapeking466]

I read an article on a very reputable high quality supplement companies website claiming these collagen supplements don't do much of anything.

[@Sailor.Ecilipsia]

Same here. It really worked for my knees.

[@SuperAmazingAnt]

Well how much did you eat protein before that ?

[@loungeactchannel]

Only watched half of this but let me guess…she gives her product a 10/10 even though it’s mainly just NR…??

[@ThriveCollective1188]

She doesn’t impart much knowledge beyond what many of us would know from our own cursory examination of recent research papers but a few interesting things I didn’t know were discussed. She contradicted herself regarding Turmeric supplementation. Yes, she’s correct, you have to consume high amounts of Turmeric to reach the levels associated with health benefits but that’s exactly why high quality, high concentration curcumin supplements that include the activating black pepper concentrate are so beneficial. Eating turmeric every day will not achieve statistically significant, independently verifiable benefits that supplemented curcumin deliver

[@bperez8656]

Typical big pharma doc

[@onlyonezino]

Her argument against NMN as a precursor goes directly against taking a precursor of GlyNAC for Gluthathione production. She never mentioned finding out why the body runs low on Gluthathione, instead of supplementing with Precursors. The sub argument against TMG also works against her recommendation to combine K2 to Vitamin D. She was better off discarding the factory analogy completely since it contradicts the need to restore gluthathione levels

[@GabrielleJacobsen]

Prefer Dr. BERG

[@chamuuemura5314]

There are also other reasons for taking or avoiding TMG, especially for cancer patients. In many cases, TMG can potentially be beneficial for chemotherapy patients. Considering the pathways, if it’s inexpensive, it’s worth looking into.

[@milosfilipovic7583]

s. boulardii is not bacteria, it is probiotic fungus, it is very important to take with antibiotics

[@vanessac1965]

Yeah it's a beneficial yeast that crowds out other microbes

[@jennysiepka9900]

I think the fact that she did not know that shows her expertise is def not in the gut...

[@vegan4life532]

A very valuable yeast in the battle against Candida Albicans.

[@galyna40]

Fungi are part of microbiome

[@isaaccraig3666]

Prebiotics have been proven to be absolutely useless as a supplement Have a look at the research done into prebiotics

[@MrElmagnific0]

Sorry for my next intervention, but the story of Curcumin and it's bioavailability [15:48] is not complete yet. Yes, it's true that Curcumin's bioavailability is very poor but actually there are ways to solve this problem. The keyword here is micellar capsule packaging of Curcumin. This rises it's bioavailability up to 185 times - far more than piperines and other so called "boosters". I would not be surprised if a micellular capsule packaging would also be a more effective way to improve Nuchidos bioavailibility instead of using piperine.

[@blankblank4130]

Exactly.

[@chantalclaeys9624]

Piperine is toxic when you take it too long!

[@bq3538]

@@chantalclaeys9624 it is harmful to Live

[@chormelcivil3772]

​@@chantalclaeys9624it depends on the dosage..

[@badactor3440]

Qunol liquid turmeric with pepper

[@saradoherty3875]

why pay £80 for a product that a cheap citrulline( pathway 1) or beetroot juice (route 2) does the job of increasing nitric oxide very well?

[@Itsme-e5j]

Exactly and watermelon.

[@MsElaine122]

2mg Cialis daily is a useful protocol for nox.

[@vapeking466]

I take 5mg daily.

[@stephanygates6491]

Eating beets daily makes my bones strong! Nitric oxide not only benefits mitochondria, also osteogenesis. I'm 66.

[@larryc1616]

Viagra works too

[@ManoelGuellaFernandes]

Thank you for bringing Dr. Conlon to your show. She is brilliant. 👏👏👏😉👍

[@aldifortuner278]

Taurine, B3 and Methylene blue should be on the list

[@nikollezeinikolle6519]

🎯

[@Marge-]

Thank you very much for this detailed and informative analysis. What id also like to know is if you need to cycle these supplements. I don’t think you can be on them indefinitely.

[@mariavanbeselaere5417]

I honestly think Siim Land would be a good choice for your podcast. Next. K2 to “add” to vitamin D3. That’s obvious. BUT TMG rather not in in order to compensate for a disadvantage for another supplement. I do not discuss that. However the arguments for one combination in order to support and then later oppose against another combination?

[@DrTimPearce]

Siim is great, I am a big fan.

[@traciholland975]

She's onto everything here and knows her stuff!!

[@funksoulbrother2934]

Really interested in this and thanks for a great video. Please can you tell me the brands of the products you buy and where from. Thanks

[@mindtheprivacy]

She didn't say alternatives to generate collagen, it was t asked either. She didn't say alternatives tomfox the 'machine' instead of using nmn, she didn't say 'what she knows better ' about nmn after 5 or 6 years of clinical studies. And also nothing is being asked to further knowledge and opinions.

[@stuomsen5094]

This lady knows her stuff!

[@irinamikhailovamusic]

almost, she did not know Saccharomyces boulardii strain, and they way they pronounce NAC is incorrect but adorable :D

[@wendiconrad6128]

I just looked up this product by Dr. Nichola and it has sunflower oil. Isn't that a highly processed oil? Why isn't she using a different oil in her product?

[@mjgrant1515]

evoo would always be the logical choice, i would think.

[@bperez8656]

Meh. Is she a big pharma doc?

[@chormelcivil3772]

@@wendiconrad6128 its purely bussiness, making profit....

[@chormelcivil3772]

@@bperez8656 absolutely correct

[@123ChrisG]

Sunflower oil is completely fine.

[@onesource9527]

I would suggest having Dr. Cate Shanahan to talk about her book "Dark Calories" on your program. She has a different take on health and longevity. By improving metabolism and learning how to fine tune and optimize it, internal senescence can be delayed.

[@shuaibchaudhary5600]

What about taking L citrulline instead or L arginine :Do the same as nitric acid gummies but cheaper

[@leohanrahan1776]

Better to get your omega-3s from food and not (potentially rancid) fish oils. I've recently started eating sardines, (in water- not seed oil) a few times a week. In my local grocery store, you can get 10 cans for $10. There's about 1500 mg of EPA and DHA in a 3.5oz can. That's more than an equal weight of salmon and less likely to be contaminated by heavy metals (like the larger predator oily fish). Yes, it's more expensive ($1/ dose) than a pill, but it's better for you.

[@singularity6761]

Better avoid cans because of BPA

[@larryc1616]

No one wants to eat canned fish everyday

[@emileimilheitor3456]

Oh boy, 1:30 hour only to realize this was all a giant commercial for the ladie's pill. I'll stick with Sinclair thanks.

[@zacharyshort384]

lol

[@123ChrisG]

Both are money grabbers in my eyes.

[@MrElmagnific0]

I would politely like to add an very important point regarding Vit D and blood measurment [06:08]. Currently it is only possible to measure the transport precursor form of the biologically active Vit D directly. This precursor transport form is called 25 OH, or Calcidiol. That's usually what is measured in the blood. But the biologically active Vit D form inside the cells is called 1,25 OH, or Calcitriol and this is the relevant compound regarding epigenetic regulation inside the cells. Intracellular Vit D 1,25 OH aka Calcitriol is activated then by another agent known as Vit A or Retinol. Together they form an enzymatic complex which acts as epigenetic regulator. It turns thousands of genes on an off. Regarding this it can happen that the measured 25 OH concentration in the blood sample appears high while the bioactive 1,25 concentration inside the cells is low. This can e.g. be related to a lack of Vit D binding proteins (VDBPs) which are necessary to get 25 OH into the cells. Furthermore a high 1,25 OH concentration inside the cells is not really effective without Retinol as co-compound.

[@blankblank4130]

Exactly

[@Mellon_Musk]

Thank you again Magnifico.. have you given any interview .. you seem to know a good deal of the internal working and the fringe details that many guests miss.. I found Dr Nichola explain why she did what she rated, logical. Abt Vit D & A - you mentioned it's good to add Vit A with D3 -bt will it be better for the body , if it is going to start a cascade of genes on n off?

[@MrElmagnific0]

@@Mellon_Musk Exactly, 1,25 OH - or if you want to use it's other label = "Calcitriol" - is the active form of Vit D inside the cells. It binds with Vit A/Retinol creating an epigenetically active complex which is modulating the expression of thousands of genes. Therefore it is so crucial for cell health and homöostasis.

[@Mellon_Musk]

@@MrElmagnific0 Thanks a lot Mr. El 🙏 Do you have any blogs or pods or interviews.. pls put link here whenever you do, Do you have any info regarding what is the best way to reduce neuro inflammation and gut inflammation or both (may or may not be related to ASD)

[@MrElmagnific0]

@@Mellon_Musk , I honestly thank you in return because your questions gave me the opportunity to share my limited wisdom as epigenetic and functional medcine coach with you. No I have no podcast yet nor I am planning to start such format. I can recommand you a basic lecture around this topic. It' s a book called "Why We Age And How To Stop It", by Dr. Sandra Kaufmann. It's a must read. In general: if you want to reduce inflamation im cells you should activate your SIRTUINS, avoid stress, change your mindset (be thankful, greatful, forgetful, loving, compassionate and do not live in the past. Use good high quality oils (olive oil, omega-3 oils, no industrial processed oils from plants), reduce meat especially processed food, sugar and bad/empty carbohydrartes from sweets. Use good and pure water - no plastic bottles. Change your diet to organic plant based. Exercise, meditatitate, be spiritual, search for constructive friendships and relations and have fun in your unique and wonderful life journey. All this points are relevant to reduce inflammation. Beside that you can supplement e.g. with Resveratrol, Quercetin, Astaxanthin, Curcumin, EGCG (component of green tea) to reduce inflammation.

[@buffc.7515]

Unfortunately, this video has some promotional purposes for a product that is rated quite low for the ingredients. Everything was going very well till she dismissed the green multi vitamins cause in competition with her suppplement 👎👎👎👎

[@DrTimPearce]

AG1 has many buzz word ingredients without hitting the effective doses. What I like about Nichola is how often she talks about bioavailability and effective dosages. It's easy to sell something that seems like it would work without it actually working.

[@pramuanchutham7355]

​@@DrTimPearceso this lovely lady is named Nichola! 😅 You're right, effective dose and bioavailability should be considered. Cheap Zinc Gluconate doses at 50mg while better-absorbed Zinc Glycinate 30mg. More is not always better, meaning less is absorbed. Then there's this NZ doctor with minimal vitamins and micronutrients multivitamin at very high price, claiming to avoid 'mega-dosing'. Then he tries to meet the magnesium supplementing-requirement of 126 mg by having to take 4 capsules of this expensive brand he created. I'd rather take Magnesium supplementing-requirement separately from the multivitamins. Same with the 4700mg Potassium daily. 😅

[@DoriCampbell-AllAboutYou]

Love the longevity discussion and Profinity!

[@MyHomeExperiments]

What happened to the idea of preventing NAD decline by inhibiting CD38 enzyme by taking apigenin?

[@luismiguel69able]

For those (like me) who need clarification, when she says Amiga, she means Omega.

[@MoSec9]

Thanks for the clarification. Let me correct my notes, because I just wrote down “Eat your girlfriend regularly”.

[@galyna40]

Because she is not american

[@paulsmart5051]

She is a geordie, I understand her perfectly

[@green9832]

@@paulsmart5051 she sounds Welsh to me.

[@pramuanchutham7355]

​@@MoSec9isn't she sweet with this delicate accent? 😊

[@debddc]

S-Boullardii is for IBS-D (diahorrea) seems she wasn’t aware of that one

[@jeffs.8970]

Interesting …. I’ve been taking vitamin D and K2 with olive oil and MCT oil before bed for years and I sleep like a baby

[@deannkennedy1795]

I would really like to know the science besides what she said the circadian rhythms which can work for one at night I was in instructed that since it is a hormone, it’s a good idea to take it in the evening. I just want to take it the best time of the day, I would like to know

[@snort5203]

Excellent. This brought to light a much deeper way of pondering vitamin intake.

[@richardives5526]

She admitted she has no knowledge if prebiotic then said it's definitely a good idea to take a strain of which she's never heard!

[@Mellon_Musk]

Thank you for all the clarity around Nad .. i found the ratings and reasoning logical. Thank you Drs. Tim n Nicola

[@daveoatway6126]

This seems to be a infomercial. Her take on NMN is not consistent with my 10 year experience. I am 80. I take 2 gm NMN daily with TMG in water with electrolytes. I walk 3-10 miles a day, do expert witness work for attorneys, race a Laser sailboat and workout 3x week. When I started with NMN alone, I found my hair returned to brown from white, and my energy was much improved. I hiked the Inca Trail to Manchu Pichico 5 years ago with no problems. I also take some of the high rated supplements you do. I recently started Taurine and have found it useful and gave me better sleep. I don't see any references to peer reviewed work supporting her claims. I can't reset my age - and am happy as I am. I am disappointed with this video.

[@vroomgc]

Of course she will talk about her own product but what she had to say in general was good information and probably pretty sound advice, you ignore all that because you have had success as an individual with NMN. Products and supplements all work differently in each person, some things can work for a few and not most just like MNM can.

[@mrhenkdirecteur]

She's a scientist that uses rigorous methods to study chemicals, you're just one sample without base line, double blind, controlled substance variants, body weight dosage measurements and many more things. Very funny though. What you are claiminig about hair color, is without scientific research much more of an informercial to be honest.

[@daveoatway6126]

@@mrhenkdirecteur Where are her peer reviewed papers? Who has validated her claims?

[@IPMan-me6lo]

@@mrhenkdirecteur His 10 years experience don't need any double-blind studies, just for himself.

[@krystynaboyt1082]

❤

[@michaelportaloo1981]

She contradicts herself. Problem: Low sunlight in the UK. Solution Vit D supplementation. Negative effect : calcium deposits in arteries. Solution : K2 supplementation. Problem. Low NAD levels due to aging process. Solution : NAD precurser. Negative effect : methyl group depletion. Solution: take TMG. First OK. Second not.

[@melvinglick9446]

Great interview

[@junejuly9219]

It thought this was helpful, but overall left a poor impression. All went well until the NMN - there she goes straight for the jugular. No wonder, as it turns out she sells the product which is in direct competition with it.

[@johnnyrocket80085]

100% agree with you, it was going so well until she started to deminish NMN and had me puzzled, then her product came out.

[@BlackjackCZ]

I have noticed zero benefits from taking NMN. Each to their own.

[@johnnyrocket80085]

@@BlackjackCZ the NMN that you took was probably fake or had very little actual NMN in it.

[@arcielbaez3219]

Really interesting her low rating for collagen. I would say collagen is 8 because of the benefits of glycine. I don't think that looking only at the skin effects is fair for collagen. Would love to know if I'm missing something.

[@catahuanco]

Thank you for making this video, it has helped me clarify many questions I have had concerning these supplement of which I happened to take some of them.

[@randomperson8771]

I do take creatine. However, the fish oils I hear from many others who know a lot more about the supplement form than I ever will suggest taking it in this form well it's already rancid!!!! is the word they often use and tell ya to eat fish instead!

[@jonathonpotts5666]

that's good to hear. I already eat so many sardines. It seems pointless to take oils

[@DrTimPearce]

Omega three oils specifically is what you should take. They should be third party tested.

[@daimos6686]

I got Acne because of this fish oil supplement

[@MrElmagnific0]

Allow me another (hopefully helpful) remark regarding TMG and methylation [10:42]. I would rather not supply additional methyl-groups via e.g. TMG as long as the intrinsic methylation process inside the cells is working. Sure, the intrinsic concentration of methyl-groups seems to decline with age but in this case it is mostlikely more efficient to supplement with methylated folic-acid (Vit B9, --》bioactive Quadrofolic) and methylated cobalamin (Vit B12) which are crucial compounds of our bodies intrinsic methylation-cycle inside the cells. High homocystein blood levels can be a strong indicator for a distortion of above mentioned methylation-cycle and it's pathways.

[@Mellon_Musk]

Wow.. i was just wondering abt it.. thanks for explaining

[@Mellon_Musk]

I m ok with l-methylfolate n b12 though

[@MrElmagnific0]

@@Mellon_Musk, yes but B12 should also be methylated in order to donate the attached methyl- group to Homocystein which then is converted to Methionin. Without this step the levels of (unmethylated) Homocystein can rise to an unhealthy and pathologic level. Therefore it is crucial to check the Homocystein status via blood testing. Is it's level outside of the "normal" range I would strongly recommand to supplement with Quadrofolic (B9) and methyl-cobalamin (B12). Take it forca period of at least 6 months and retest your Homocystein status again to check whether this intervention was succesfull -》your Homocystein blood concentration should be significantly reduced.

[@willb32]

Hi! Great episode. The doctor was saying NMN isn't effective to raise your NAD levels. But she that'd there are new ways now. I am curious...what are those ways?

[@pohaa]

Taking magnesium glycinate with NAC has an added benefit of giving you the combination GlyNAC.

[@bperez8656]

And what do those do together and separately?

[@luckycappy]

I was thinking if people start taking magnesium glycinate so best to stop glycine isnt it

[@pohaa]

@@bperez8656 together to have the GlyNAC effect, is what I understand.

[@pohaa]

@@luckycappy too much of anything can be an issue. Taking magnesium glycinate will give you a dose of glycine, so dose accordingly, I believe.

[@SJ-is5ko]

What’s up with Asthaxanthin? Any updates on this? There are some studies on this but any benefits? Can someone enlighten me?

[@raibalama]

Commercial answer especially the NAD alternative

[@wmp3346]

I give her a 10 ❤

[@awolf913]

Simp

[@matkapuhelin2011]

What a shame that an useful video is just used for marketing her very expensive nad+ booster which in clinical trials boosted nad+ only by a tiny fraction.

[@vroomgc]

Instead of looking at it that way just take it as good information on everything else it provided

[@11kwright]

@@vroomgcExactly, with that stupid mentality he’s missing out on good relevant and informative information. Can use this video for one’s own health benefit. Most of these doctors promote their own products even Dr Brad Stanfield, Dr Eckberg etc do the same but whilst also giving beneficial information.

[@sandrasmith5943]

Can Dr Nicholas supplement be taken while on thyroxine? Thanks for such a brilliant video.

[@lingchinn2389]

Dr Nichola knows what she's talking about!

[@evarkf]

I wish they would talk more about all these supplements on gut health. I strongly believe that collagen peptides caused me collagenous colitis. And that glycine, tmg, oil supplements and more, are causing diarrhea too.

[@DrTimPearce]

I can imagine this is a side effect of many supplements. Gut bacteria may be the key and may be one of the fundamental variables in many drug side effects and diseases.

[@andanssas]

14:13 "I don't think you should *take a supplement to deal with another supplement* negative effect"... So is vit. K2 an exception? As mentioned at 3:53, K2 avoids vit. D3 calcification issues and thus "should be paired together" to avoid this negative effect... 😕

[@kathisottosanti1240]

Loaded with great information! Thank you!

[@hanss4367]

What I missed in your supplements stack are: Resveratrol, L-Taurine, L-Glutamine, L-carnitine, L-Theanine and Magnesium L-Treonate

[@A2Fan71]

One thing she didn't state about Turmeric. If you are taking a Curcumin supplement, it is better absorbed when you eat it with food, particularly fat.

[@Mac-u2n]

The comments didn't seem logical, in first instance she cautioned D3 should be taken with K2, and high D3 could be dangerous without K2. Yet she demonised NMN for needing to be taken with TMG?

[@praveenreddy4427]

😂

[@Mellon_Musk]

From what i understand those are totally different supplement pairs and different impacts

[@Mac-u2n]

I watched with an open mind, genuinely interested in views as a new user of NMN, the illogical reasoning and lack of detail didn't expand my knowledge base. The interviewer was polite and well mannered, but not probing or inquisitive

[@bperez8656]

When I hear that level of ignorance I begin to think Big pharma doc

[@nicedoppy2077]

noo...D3 is ok without K2 buuut could be better with K2 to absorb better and give to the bones more benefits...

[@mannydacamara9576]

I would have liked to hear Dr. Nicola's thoughts on taurine supplementation.

[@RobbyFindlay-uq2dy]

There are abbreviations used here with no translation or meaning. I am not an apothecary (someone who prepares and sells medicines and drugs, a chemist) and so you could do just as well if you were speaking swahili. At about 35 min's in it felt as though I was sitting in the middle of a Bantu village. I couldn't make out the abbreviations, which were many. What I did understand was interesting and informative. Translations please.

[@philipvanderwaal6817]

I totally agree with you ,@37.00 I lost her in the abbreviation of the alphabet

[@clairelove7012]

I’ve been taking NMN for the last 3 months, I’ve never felt so well.

[@pamelladukevarnon7978]

Great info!! Thanks! ❤️

[@timskolnik3819]

For her to say TMG isn't beneficial unless you need it is so unbelievably ignorant and negligent. Wow. The benefits of TMG for EVERYONE are a mile long.

[@bperez8656]

Big pharma doc

[@paradisekohchangstyle2150]

TMG to reduce homocysteine levels, right? Why doesn't she bring this up?

[@cathycoppin5682]

Nmn does work it’s change davied Sinclair body age so it does work and seen blood texts for people who took the nmn and there levels have gone way up

[@NM-qc2dh]

Why do these people want to live forever anyway ? Do they think that their contribution to mankind is so great that we should have to suffer them for longer than the normal span? Vanity. What a desperate time we live in.

[@DrTimPearce]

Happy people want to keep living. I hope your contribution goes beyond these KZbin comments.

[@fidrewe99]

TMG because it can replace some choline more effectively, safely and cheaply than choline supplements and because it helps to lower homocysteine and make sure to get enough methylation and methionine even in a diet favourably low in methionine. It's also good to maintain or improve cognition, mental health, muscle mass and physical performance.

[@pohaa]

Omega 3s are easily oxidised. There's research coming out now that raise some concerns about mega-dosing.

[@pohaa]

Krill oil is arguably better as it has Astaxanthin in it (giving it the red colour) which is a powerful antioxidant.

[@barbarafairbanks4578]

'However, other studies have found mixed results. For example, a study published in the Journal of Clinical Psychiatry in 2019 found no added benefit when researchers combined omega-3s EPA and DHA with the antidepressant sertraline (Zoloft). A 2016 analysis of 40 clinical trials also found mixed results " Depends on which study(s) one wants to believe

[@Sedefsweetpie]

Long before lines and wrinkles happen , there occurs an expression loss. This is the stage we need to intervene to work on levels of muscle, adipose, nerve and capillaries. Long before any lines happen expression is already distorted. When you want to understand a system. Look at the most energetic parts. Such as nerve such as capillaries and muscle They do create the most distortion. All rest otherwise is tale to do the best in a worst. Worst bc modern medicine has never explained facial changes properly. Mean no disrespect🙏

[@randlejackson3710]

Hi Dr. Pearce...great post! What do you know about nano-delivered curcumin?

[@Ms17796]

For sure some promotional purposes. For her no supplement worth it .. um I have taken a lot of these supplements and they have worked wonders and helped me so much . Contrary what pharma says . I’m for all those supplements.

[@ThirdDoor-ve1iz]

I watched the presentation which struck me as mostly marketing. There was a lack of scientific rigor by Dr. Nichola. I did some digging until I found the ingredient list for Time+ proprietary “formula” which doesn’t match the asking price. She should go back to her laboratory job, and leave the storytelling to Disney.

[@scarletohara6743]

it would be more helpful if the visiting expert would reference studies that could be read. Otherwise it is anecdotal and unreliable, don't you think?

[@michaelportaloo1981]

Failed to identify high levels of oxalates in turmeric.

[@scarletohara6743]

I;m not at the end yet, but so far, you don't ask anything about what the underlying causes are that need to be fixded before supplementing, maddening

[@shelly7017]

Because of my genetics test results, my functional medicine doctor told me to stop taking my vitamin D3 with K2 and just take D3. He also told me not to take any calcium supplements. I have gene mutations for D and B vitamin absorption.

[@jakobw135]

When it comes to taking omega-3s - which algae oil supplement for a vegan diet would you recommend, in view of the fact that many of them come together with a substantial amount of omega-6s?

[@ThriveCollective1188]

Sea buckthorn oil gives a balanced ratio of omega 3,6,7 and 9. Herbs of Gold is what I use.

[@rainbowtravelingyogi]

It’s interesting that so many people seem to only mention fish as a source of dha… fish eat algae and seaweed which is where THEY get there omegas from…. So we don’t need a fish supplement, seaweed and algae supplements and just basic consumption would suffice….

[@larryc1616]

The epa/dha from seaweed and algae is poor vs fish oil

[@viktorandre8545]

Vitamin D3 has a half life about 15-25 days in your system...I do not understand how taking it in a morning or evening would impact your sleep.The important thing would be your 25Hydroxy level. Regarding K2 and calcium , vitamin D3 supplementation will NOT raise your calcium level unless taken pharmacological level. 50.000-100.000IU daily for long run!! In that case having vitamin K2 will not be of help either.

[@Rafaela-v7w]

Hello, invited lady could read the medical guidelines to learn what Saccharomyches boulardii is important important for.

[@pramuanchutham7355]

Well, she may not have enough time in front of the camera, and to learn of atleast 5 other Lactobacilli and 3 Bifidobacterium.

[@AstonAcademia]

Thanks. Great video! Subbed. Thoughts on MSM for joints and detox?

[@kroyal4296]

Any genetic testing you’d recommend over others?

[@nancydayo8392]

Hi, kindly write the names next time. Missing out on a few

[@althe]

omega 3 fish oils oxidize an hour after produced - unless direct from the fish with its antioxidants.

[@eleanorweiss4217]

What about omega 3 from flax oil?

[@bperez8656]

My doc makes pills that use no fish

[@dmitriya8337]

@@eleanorweiss4217 It has not omega 3 but ALA, is not the same.

[@cgsonic1968]

I am taking NMN and I feel on top of the world. Even though this is science, this is a kind of a subjective science. On the other hand I took creatine for the longest time and I did not feel a difference. Again, subjective...Not sure if she talked about Niacin or vitamin B3 but i stopped the video 1/2 thru it.

[@Chris_Faraday]

I love her angle on NAD and precursors and the reason for NAD decline - but minerals and oils are key for recycling

[@alextang2234]

Collagen shots are heavily promoted as a health drink - but what kind of quantities and what is the absorption capability ?

[@baldwad]

When she suggested Curcumin in favour of Turmeric, she’s wrong according to Dr. Greger’s interpretation of nutritional studies. The whole food is better than an isolate. Is she selling Curcumin?

[@michaelboller5314]

But fish oil and Omega 3 capsules failed in most studies. I guess fish is much better.

[@kellyku5404]

Your NAD tmg argument you dispelled yourself. Taking k2 to stop calcification from D3. Also tmg has a strong musvle recover post exercise component to it.

[@juancassanello5219]

excellent inputs and tips. thanks

[@MostAlpha]

Very interesting wrt Methyl depletion.