The Mitochondria and Calcium Homeostasis Part 1

[@juliandong4075]

I'm not confident that the two membranes of the mitochondria are from a one-membrane bacteria being engulfed in a vesicle. I've read online that mitochondria are descended from gram-negative bacteria which already have 2 membranes. Another thing to note is that the intermembrane space is not actually acidic. It's only relatively acidic compared to the matrix. The pH of the intermembrane space is still slightly above 7. Finally, uniporters are not named uniporters because they only allow chemicals to flow in one direction. They are named uniporter because they only transport a single chemical. If the uniporter refuses to conduct calcium in the other direction, then it shifts the equilibrium and violates thermodynamics. Transport proteins are ultimately just catalysts, so they don't change the equilibrium of the system. If the rate constant into the matrix is increased, then the rate constant out of the matrix also has to be increased to make sure equilibrium is not changed. In spite of these inaccuracies, the video is still great.

[@SnowWhite-ve1ph]

why uniporter considerable secondary active transport??

[@kellyushedo469]

Thank you. Great clarity.

[@varshasanjeev3771]

Thank you for this☺