Mitochondria: the cell's powerhouse

In this animation, Professor Rob Lue introduces the mitochondria, the powerhouses of the cell.
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[@bradenbellinger3025]

The mitochondria is the powerhouse of the cell

[@Li0nX]

Thank you for putting the title into a complete sentence!?!

[@budmeister]

It's also a quote from a videogame.

[@direstr7768]

i get it, mr mane

[@powerfulmind1722]

@Kay Kay 🤣😂🤣😂🤣😂🤣

[@bennyheers846]

Mitochondria are the powerhouses of the cell

[@abrahamtellez592]

It's incredible how many years of knowledge piled upon knowledge are condensed into just this 5 minutes.

[@The_Essential_Review]

For real...

[@hereb4theend]

A lot of these knowledge survived great wars, plagues and fires. Soon it will endure the great AI replacement. *plays Terminator theme*

[@chan625]

Even more years of evolution piled upon evolution

[@ross-carlson]

My biggest take away from this video - time/history is FUCKING VAST. I really started to contemplate the deep time it took for this to evolve natural. The billions of billions of billions of billions of billions of reproductions, virtually all of them failing but enough survive due to natural selection to create this symphony of nature. And, as you say, the amount of human knowledge and time spent gaining that knowledge condensed here is also staggering. Thousands and thousands of human life times of asking "why" and not accepting "god did it".

[@misovejasescuchanmivoz]

@@ross-carlson You are delusional if you think these extreme complex processes exist due to chance and time. You can see extreme and complex processes in nature like in time and space laws, gravity, seasons laws that are in perfect harmony with existence allowing these organic machines to exist as they do, things like eclipses which have the moon and the sun in the perfect size so we can see them from earth, or mathematics, where did math come from, was it created by chance? if you think everything in existence is made by natural selection you have more faith than I do.

[@speedstriker]

I knew that the MITOCHONDRIA IS THE POWERHOUSE OF THE CELL, but I didn't know they were literally tiny biomechanical power plants. This is amazing!

[@mwils51]

Very: Psalm 139:14 - I will give thanks to you because I have been so amazingly and miraculously made. Your works are miraculous, and my soul is fully aware of this.

[@speedstriker]

@@mwils51 No kidding. God is one heck of a craftsman.

[@mwils51]

You have peer reviewed science that concludes "There is no God"? No, then your claim is baseless and you are showing how little you know about science.

[@discovaria9507]

They're very useful Bacterium

[@rsrt6910]

And to think mitochondria used to be living organisms, then evolved into mere organelles within other cells.

[@abenassini]

Beutiful and elegant animations. I’m a physician and I’ve never seen the process of cyclic AMP presented in such a graphical way.

[@Caterina2022]

Me too. In order that i m studying frequencies by Rife and morphologic camp.

[@GlynWilliams1950]

Amazing. I want to understand what I saw

[@kampfmuffin3535]

same...

[@albertomolano]

Think of an AA battery: it has a (+) pole and a (-) pole. The (-) pole wants to "give" electrons, the (+) pole wants to grab those electrons. The flow from (-) to (+) generates the energy that lights up a flashlight. The FOOD you eat is like the (-) pole: it has electrons that can be easily removed. The OXYGEN you breath is like the (+) pole: it wants to grab those electrons, badly (that's why it also rusts nails). The mitochondria is where electrons from food jump through a series of intermediate protein complexes with higher and higher affinity for electrons, and end up swallowed up by the oxygen you breath. That flow provides the energy that keeps you alive.

[@fatimamezouaghi9780]

Alberto Molano thanks😊

[@albertomolano]

You're welcome. I have always thought this is one of the most amazing discoveries in the history of science.

[@NortheastGamer]

I never understood why we needed oxygen so desperately and in such great quantities and no one could give me a helpful explanation. After reading your comment, things clicked for me. Thanks! :)

[@Proversiongamer]

Never thought I would spot a mistake in a HarvardX Video, but the ATP Synthase subunit is called Fo not F0 (zero). The letter o stands for Oligomycin.

[@ferdrewflores3612]

Uuuu ! 👍

[@Bman-1970]

Wasn't it also spinning in the wrong direction? Just watched a video on ATP. It was spinning counterclockwise to take protons and send them into the matrix

[@danthadon87]

@Luca No You're the hero we need.

[@ferdrewflores3612]

@@danthadon87 0💪💢💯

[@friedchicken1]

@@Bman-1970 I think it spins the wrong way in no markers, conspiracists, and flat earthers

[@AnneAndersonFoxiepaws]

Apart from the fact the whole mitochondrial set up is so amazingly complex, this makes it look really beautiful too.

[@aspektx]

Seeing things like this makes me realize how inconceivable the stretches of time are for things like the mitochondria to develop. All the failures, the variations that partially worked, and the diversity that must have occurred on the path that led to something so small and so significant.

[@ahmadrashid4853]

if ATP synthase came about by millions of failures to be this perfect and in harmony, all the other times it failed would not be possible because if it did not work the first time, the creature would not be able to live long enough to replicate for mutations to have a chance of occurring so it is impossible. It is like saying a human without a heart had children who then had 1/4 of a heart and their offspring mutated a proper heart which is impossible because if it wasn't perfect at the beginning, the creature would not have survived to be able to replicate in the first place.

[@electricity2703]

I agree with you all guys. How can these complexes develop by chance even by natural selection? It is impossible.

[@tacitozetticci9308]

@@ahmadrashid4853 nope. It used to work differently but it did work. You can get hints at how the older systems were by looking at more ancient creatures like the anaerobic bacteria. Yours is just like the classic "what use is half an eye?" argument, but we know it's not a bright argument. A simple eye can only distinguish between dark and light, it could be a sensitive surface appearing somewhere on the skin, but that's okay because that's already an advantage and the mutation will survive. Eyes have developed separately tens of times, and so did the different ways of distillating energy like ATP synthesis. The fact that now we're stuck with these organs and we need them to survive doesn't mean that it was always the case. Many creatures live without hearts and circulatory systems just fine, they'll just dissolve the nutrients in their body and that's it.

[@o_sch]

@@ahmadrashid4853 no, either the cell had some other way for energy or the small individual things like proton pumps randomly formed and there were millions of failed versions beforehand.

[@ahmadrashid4853]

@@tacitozetticci9308 So where is mid stage ATP synthase with half a rotor missing?

[@OGMann]

Mitochondrial dysfunctions are implicated in a significant number of pathologies. It's a fascinating field of study. The various hypotheses of the organelles origin are equally interesting.

[@stefanofalone]

Great video, however at 2:38: "Electron transport in complexes II, III and IV is coupled to pumping of protons..." Actually, it's I, III and IV.

[@wmayo44]

Yes, and II helps I, III, IV do their function.

[@parulshukla2153]

Harvardx....I m a practising pediatrician from India. Such animation weren't available in studied in the medical school many years ago Seeing this animated medical teaching makes me feel my medical school revisited A back to school experience

[@fierrots]

It is not F0 (zero) but FO (oligomycin-sensitive)

[@the1tigglet]

I have to say these images are amazing and explain so much about cellular energy and how it works. We're basically electrically charged powerhouses!

[@caesarskiba9008]

So amazing. Please never stop making these types of videos

[@winneriruke9104]

Very clear presentation, than you for information.

[@NotOkBoomer-gr5lb]

Just stumbled over this vid. It's an amazing work and very interesting explanation of what's goin on in our bodies. Thank You!

[@octaviolara7171]

Amazing and spectacular! The most important function into our body! Easiest explanation! Thanks a lot off!

[@RahulBhai-yb3xu]

superb explanation..

[@-AnyWho]

they already have a video game based on this (still in early stages of development) ... soon little kids will understand this better than we do

[@Malkovith2]

What is it called?

[@dynda9713]

The game is called Thrive

[@yogayantra]

brilliant! Thank you so much. Makes my course understandable

[@johnmartin5240]

Amazing. And mind blowing at the same time.

[@convergence708]

Спасибо большое за визуализацию работы митохондрий , что в свою очередь очень помогает осознать сам цикла Крабса и запуск электротранспортной цепи.

[@bikeman9899]

Excellent narrative and graphics

[@ferdrewflores3612]

You and I are part of these FASCINATING processes !! ☝️💯💪👏👏👏

[@KeithJohnson.]

Incredible animation and explanation

[@Burhansager]

Beautiful explination

[@harshsinghal4342]

Too good. Keep making them👏👏👏😊😊

[@parulshukla2153]

Awesome animation

[@AMeDAS.Hunter]

2:29から　水の分子はマトリックス側にできるのに、このアニメでは膜間腔側にできている。これはまずい。 2:29　Water molecules are synthesized on the matrix side.But in this animation, molecules of water are synthesized on the intermembrane space side.

[@higherresolution4490]

At MINUTE 2:45 a mistake is made. Complex II does not pump protons into the intermembrane space. Complex I, III and IV do that job of creating the proton motive force that drives the 8-proton rotation cycle of the ATP Synthase turbine.

[@raplopez4258]

Thought so! He's testing you to see if you're paying attention.

[@adamrezabek9469]

Yes. I felt so good when I spoted (minor) mistake in HarvardX video.

[@aartibhanderi-shah5333]

Stunning film on energy - in awe of nature and its creation

[@jackpullen3820]

I want to see more on their interaction with Microtubules....

[@JCAH1]

Excellent work.

[@ajays007]

Excellent video.... thanks

[@edstud1]

How this was all conceived or designed is mindboggling! At any rate, I love these animations.

[@jesterflint9404]

God has infinite wisdom and only he can do this.

[@b.r.1523]

🤣@@jesterflint9404

[@johnbollenbacher6715]

Excellent video. The only thing I can suggest is that you find ways to highlight the portions of the video that you’re talking about from moment to moment.

[@DyanaBunnyPhD]

Delightful watching your animations

[@bencyber8595]

the animated picture , are they real OR just imagination , for understanding purpose in our learning .

[@mightychondriaofthecell3317]

Watching videos of my awesomenesss all day long.

[@feymreichmanostenrn8751]

It is indeed a contemplative wonderwork, considering that this is a tiny element in every cell and this happens in every cell, all the time....wow.

[@jmcgraw6]

Yes 🤯 and our feeling of being mind blown is assisted by those same mitochondria we just witnessed in this video rendering. 🤯 🤯 🙌

[@princetamrac1180]

Ok so here are the mistakes i gathered. Complex II doesnt transport protons, only I, III and IV do. The animations shows water molecules being produced in the intermembran space at complex IV, when actually they are produced on the matrix side. The subunit Fo of the ATP-Synthase is called Fo and not F0. O stands for Oligomycin. Finally the rotation of the ATP synthase is depicted in CW direction, but it actually spins CCW. Still amazing animation tho.

[@edstud1]

I love these visualization videos!

[@bencyber8595]

which means , this picture are not true , BUT for illustration purpose .

[@oldsteamguy]

breathtaking

[@rebanelson607]

This is a first class video! The graphics are amazing.

[@Univers314]

Wonderfull work.

[@socalpal8416]

...had no idea that Mitochondria were capable of fusion, division and mobility. Stunning is an understatement.

[@The12thSeahorse]

Amazing graphics!

[@deanroddey2881]

As a software developer, I now know what I sound like to non-software developers.

[@jongtes5570]

Fantastic!! I know what I'm going to study

[@ghostmedic86]

I knew what was being said. Take a cell bio class and it will all make sense! Great stuff!

[@manuelgarciabarbero1872]

great job!!!

[@EffySalcedo]

Amazing Visuals 💖💐

[@aftabnadim]

great animation.

[@dtasat]

it is fantastic! thanks

[@UQRXD]

The CGI animation was just as I imagined this process happening. Most Fascinating.

[@littlebag123]

Lovely thank you amazing.

[@elba_magellan]

Beautiful...

[@loudmoderns120]

I don't like to throw around words like "awesome" to much, but this is AWESOME! I love learning about this stuff; and content like these clips, or better, the full documentaries are amazing. Especially since its able to be done with such high fidelity; that is, of course, if this information is accurate. Assuming the content makers have the right information, this is indeed awesome. Well done, much appreciated:-)

[@pamrhoten4144]

Awesome video!!

[@mohdsaleemmalik4073]

Inspiring video

[@TheStarflight41]

Intelligent design couldn't be more obvious.

[@pageread7135]

Thank you

[@kopronko]

Thank you.

[@Devo491]

The exquisitely complex process in this one aspect of cellular function is a tribute to the power of evolution. Given enough time, anything that works will be refined to a ridiculous degree.

[@davidhuasca9831]

Incredible

[@randomsongs9907]

Amazing 😍

[@paulbracken6216]

Amazing!

[@jchaigh5715]

How does Cell Danger Response change mitochondrial function to producing more inflammation and less energy when sick or toxic? this was amazing. thank you.

[@pttrro]

Awesome

[@joulecad9229]

Excelente

[@calciclasses]

Woww!!! Great job

[@MA-ho7kr]

Very intersting video👍

[@gforcedod]

So much wealth, in such a short video.

[@aprilhicks3474]

Beautiful

[@zamiralice5498]

How can anyone believe something this complex is the mere product of chance?! This is clear proof of a magnificent designer.

[@lindascanlan6317]

Oh yes! Definitely....there simply is no other explanation to the question - what/who else but a grand designer could have made this process and is controlling these processes still...mind blowing stuff .

[@jordough4495]

I'm pretty sure you guys don't understand probability or statistics

[@eilonj]

A magnificent designer would have made it much simpler...

[@bcrookegmailcom]

Every thing else I’m reading indicates that the F0 ring and substructure turn counterclockwise when viewed from above. Just a point of curiosity, but it could be significant as we dig deeper into the function of the additional structures.

[@natecw4164]

I was completely lost until you brought up F-Zero. I totally remember that game. Basically I'm a SNES and the mitochondria enable Mode7 graphics. Got it.

[@karmakazi219]

I only understood a fraction of that but it was still amazing.

[@lourdthebluefoxie]

I like this type of videos

[@tomorourke6301]

...doesn't matter how many times I watch this video: this video always makes me happy to be Clean and Sober, y'know?☺

[@Bman-1970]

Its like watching this take place under water. Such fluid like movement

[@dweebteambuilderjones7627]

It IS taking place underwater. Cells are full of water.

[@anishapandey10b-69]

Nice video

[@briang.valentine4311]

Rotation of the Fo shaft between inner and outer membranes in the proton pump is CCW, depicted here in CW direction 3:20

[@HarvardOnline]

See all of Harvard's online courses here: harvardx.link/4jxyv

[@NameNotAlreadyTaken2]

I'm made of self-replicating nanobots

[@stargarden2577]

Nanomachines, son!

[@rsrt6910]

Essentially, yes.

[@wheaties2912]

The mitochondria is the powerhouse of the cell.

[@roccosiffredi2818]

i have to watch it all over again

[@williamkyburz]

This is Mitochondria 405. It needs introductory context, which you can find in some more elementary videos. A few good ones on KZbin.

[@burritosburritos]

That was just fawking awesome.

[@Relampiano]

2:39 Complexes I, III and IV (not II, III and IV) pump protons from the matrix to the inter membrane space.

[@youllneverknowme2195]

I was about to say this too🤔🤔🤔

[@Jose-tx1yx]

My textbook confirms this. Complex II does not show protons being pumped. It only shows the accepting of electrons from FADH2.

[@zeljkom.svedruzic8406]

nice

[@goedelite]

The content of this presentation is perhaps a laudable summary for persons who are already very knowledgeable about the function of the mitochondria, but as a physicist without such training I am not among the knowledgeable. I wonder what function the video serves? Does it help the already informed to clarify their understanding? I surely hope so. It is a very impressive work.

[@RapidBlindfolds]

its useful for people who are visual learners

[@chatsworth777]

I read some of the comments and, there is no mention that the mitochondria is a foreign body with it's own DNA. Reportedly, it is a VERY old organism that lives symbiotically within every cell. Reportedly, it was only adopted one time LONG ago. Was it first adopted on Earth? Ar there any cells that produce energy without mitochondria? Fascinating stuff.

[@antonlencses8622]

Thats distinction betveen procariots and eucariots.

[@nur9871]

Small remaining portion of human genetic is located within numerous mitochondria. It is very unique organelles.

[@davidcardinal3654]

They made a video game based on this idea, parasite eve. Really good rpg for the ps1

[@rcchristian2]

Cells go around enveloping and eating other cells. Eventually a mitochondria was ate by another cell (enveloped) and it somehow survived. It then reproduced and thrived inside the other cell, living symbiotically inside the cell, helping both to survive. There must have been many other organisms that were enveloped that destroyed or harmed the cell, until one like the mitochondria survived and thrived and actually benefited the cell. Without mitochondria (singular, mitochondrion), higher animals would likely not exist because their cells would only be able to obtain energy from anaerobic respiration (in the absence of oxygen), a process much less efficient than aerobic respiration. This evolution allowed the creation of higher forms.. but the lower forms still exist and thrive...

[@MoiLiberty]

@@rcchristian2 That’s exactly how I understand it. The mitochondria emitted oxygen for who know how many thousands or millions of years. This oxidized iron creating red mountains. That oxygen was later used by the aerobic organisms which pump out CO2.

[@saigonmonopoly1105]

This prove it the keys to enhance our energy

[@rickaguilar1833]

The miracle.of life! The mitochondria, the how and why we are all in existence!

[@vikashsinghrajput2930]

Which software are use for making animations

[@ammaryasser418]

good

[@fyz7047]

Pretty good 😊

[@mrniceguy4277]

I will soon start my PhD in molecular medicine and I still find it so incredible how such things evolved! I mean look at this!

[@dividingword]

It didn’t evolve, it was designed that way buddy. You think something this complex could evolve into what we see today? That takes way more faith to believe that, and is mathematically improbable.

[@mrniceguy4277]

@@dividingword Naah, mate. I suggest you to read Chance and Necessity by Charles Monod. Interesting book. Also, humans are not capable of understanding how much time billions of years actually are. It is a reeeeeeally long time for things to happen by chance

[@dividingword]

@@mrniceguy4277 again, takes way more faith to believe in chance or happenstance than a guided process. I will give nonbelievers that, you guys sure have strong faith!

[@carpenterabc]

I have spent 18 years in college, and the deeper you study a topic in science, the more "chicken or egg questions (which came first) " ...you discover, the more you agree , with Einstein ..."everything is a miracle" from God! ....otherwise you are a fool that believes in assumptions (which evolution is based on), and assumptions is Not Science. True science is based on experimentation and the scientific method and Not "pet theories" , alias assumptions.

[@hygrobiology]

Thank you for this Videos on KZbin and Best Regards from Hygrobiology CEO Thailand

[@Orlor]

I'll pretend that I understood a single word of that...

[@177suzie]

me too

[@ShadeAKAhayate]

It's not that complex in fact. Watch some videos of this kind and then open some online book on the matter. It is mind-bogglingly complex in details and specific "bio"chemical reactions that make it, but the concepts are pretty easy to grasp. If you don't go beyond level displayed in this video, it's really simple since there's a whole giant scientific machine with it's explanation port open to you (producing said videos or pictures or drawings).

[@cjhepburn7406]

The ATP/ADP carrier is basically a wormhole. There's some understanding.

[@raplopez4258]

The reader makes it confusing.

[@cjhepburn7406]

@@raplopez4258 No Rob Lue is pretty good. It's just a complex topic. Hard 2 grasp.

[@banshidharmuduli4381]

Nice voided