The Molecular Basis of Life

[@SomeoneCommenting]

One thing: remember that all these molecules are reacting while they are submerged in tons of other molecules of other stuff around them. There is no "empty space" between any of these things, this is only done for visual simplicity.

[@rodschmidt8952]

Yes, I am impressed with the aim. Things don't float randomly around; they are in some kind of structure that channels them.

[@pilotavery]

Additionally, adenosine is constantly flowing around too and is essentially consumed, harnessing energy stored as electrostatic and mechanical in this protein which is consumed constantly by these little motors. That ATP is gotten from our blood sugars.

[@jdstillwater]

They also left out Brownian motion, which if included would make everything all jiggly and headache-inducing to watch.

[@theultimatereductionist7592]

INFINITELY IMPORTANT POINT! Well said, SomeoneCommenting!

[@jonathanbrazeau970]

@@rodschmidt8952 great, that was my question... in a way, that makes the animations sort of misleading

[@00bikeboy]

I"m at a loss for words. I don't know what's more mind blowing, the biological processes, or our ability to have figured this out.

[@hihtitmamnan]

i'd say the processes

[@nicsanchez2255]

And then you realize that you're just a bunch of cells using this process to understand this process.

[@vitalygoji]

No big deal. Just random molecules randomly bouncing against each other. That's what idiots saying.

[@sevsev4078]

@@nicsanchez2255 Inception! :D

[@wafflegamerxox6575]

Yes

[@jooky87]

Amazing. Mind-blowing really. How do we deal with the question of what is life and what is alive if we clearly see molecules acting in such an orderly manner directed by their electrical bonding energy and some heat. The speed, the amount of information, and the precision; just wow.

[@jooky87]

spaceDJ like the enthusiasm, and yes still learning a lot about how “life” works. And what’s great is that we are using advanced instrumentation to examine that. Unfortunately that is not at all like “black holes”, of which we know nothing about really except ironically their mathematical interpretation.

[@JerseyLynne]

@@jooky87 there are no black holes....see Electric Universe Theory...Thunderbolts Project is the You Tube channel...No dark energy or matter. The universe is electric, not gravitational...it's worth checking out...these ideas are all based on misinterpretation of the red shift.

[@jooky87]

Lynne Benson lol, yeah I already am a big fan of the thunderbolts project and the electric universe, I’ve even read Halton Arps books on problems with astronomical red shift. That’s why I said black holes are “mathematical”.

[@mobiustrip1400]

The answer is beyond the question.

[@Skeleton-bs7zy]

Dave R Why do you say that

[@MrSkaizZ]

Feels like the tiniest episode of "How it's Made"

[@eyescreamcake]

How You're Made.

[@Tym-de6di]

Yes, made by God!

[@ryantab]

@@Tym-de6di how do you know

[@Tym-de6di]

@@ryantab God revealed Himself in His magnificent creation. Could that kind of highly advanced mechanism exist without creator, designer?

[@ryantab]

@@Tym-de6di diamonds, one of the hardest and most complex things, are formed from just carbon under pressure with immense heat. Your logic is that, this is so complex therfore god, when it could just be anything than. You could say this is so complex therefore aliens, therefore flying spaghetti monster.

[@katiekat4457]

WOW!!! I am absolutely flabbergasted by the graphics of this video. I can’t believe that it is even possible to make a video with so much going on and with so many things on the screen moving along. Whoever did the graphics for this video are crazy incredibly talents person or people. This video was so amazing to watch. Not to mention the parts where they took the couple of seconds where it was the actual microscopic filming of a real cell but colored everything in so they could point out things. Like when they showed a real cell dividing under the microscope but colored in for a few seconds and then seamlessly slid right back to computer graphics. Although this entire video obviously looks like computer graphic and not real life it is by far, I almost want to call it art. Amazing. My head is spinning from the greatness of the graphics. Then on top of that the audio and narration are spectacular as well. I have never seen anything like this video before. Plus what how much I learned or understood more clearly from this. I am blown away by this video. All aspects of it. Wonderful video!!!

[@lesliesylvan]

Took the words right out of my mouth.

[@dalegreer3095]

Part of the reason these animations are so good is because the molecules are mathematically modeled. The animator doesn't have to control each and every movement of the walkers, for example, because the physics of the model helps everything happen. Not shown are the water molecules that are pushing everything around, making things jiggle. The animator makes them invisible so you can see the action. The animator will also help guide molecules to their destinations, because in real life they depend on just bumping around until they hit something they can latch onto. So there's a combination of art and math that goes into it.

[@slimyblob3198]

I’m flabbergasted by the length of that comment

[@gelatinocyte6270]

What are high-end video games Edit: also the 2nd reply said it better

[@tonybarfridge4369]

How much more amazing are the cell processes and the programming behind it all

[@frankdejong9584]

I hardly could hear the music because of this man's voice

[@alexanderkorol677]

which man?

[@anand.suralkar]

Well

[@anand.suralkar]

Yes he doesn't understand we are for the music and not his biology bullshit

[@anand.suralkar]

@Hubris lol are u for real he is being sarcastic i think u r not ,?? Ate u too?

[@lvjkahvlwertfg]

@Hubris too bad this is foreground music with some background mumbling

[@mcnamaratroy2994]

i am incredibly excited by the technique that is used to show how the molecular mechanism of dna replication and transcripton is shown in this video. even the detailed enzymes and proteins are presented. i really appreciate for this great contributon to both science and education. thank you!

[@digocr]

Understanding this makes me forgive everybody and be peaceful.

[@richiegurdler2793]

science tends to have this humbling effect, doesn't it

[@yifan91]

why?

[@rashoietolan3047]

Richie Gurdler no , fuck no

[@digocr]

@@yifan91 Because we realize are just atoms. So why bother and suffer? :) That's the teaching of the Buddha, great scientist.

[@BroBill-y9r]

I know you mean.

[@josephinejuette9798]

This entire video is so mind blowing im at complete awe right now - definitely deserves A LOT more attention. Its one of those things that makes you appreciate life and what a miracle it is, and manages to somehow . And it only gets more complicated. Thankyou to everyone who made this, im so grateful to have been able to see this - it is so incredibly fascinating and the video is put together perfectly, I have no clue how people managed to put this together as an animation or even discover all these processes it is just wow, I have no words.

[@johnslight3762]

As complex as the Universe its self, never take life for granted, only the amount of particles and its role in the infinitive proceses is mindblowing. My sincere respect, for all these researchers involved in the making of this video. Respect for all the pioniers and there knowhow and perserverence too make this possible !!! What a wonderfull world this is, cant grasp it, if other worlds have the same, or even another form of lifesystem with even other chemical properities and with different, also complex workingsystems , what a development....

[@t.j.ziegler4567]

I remember first time I watched this, that was back in highschool when I was studying the topic of protein synthesis for my biology finals. I accidentally got really high and I was so blown away by this video that to this day I come back to rewatch it every 10 months or so.

[@ModMINI]

Sure, it was an accident :P It's truly amazing. These are essentially nanobot!

[@wardygrub]

Did it be make you feel religious or spiritual at all?

[@vipertown9025]

I wish I had this in science class. This animation tool is amazing. It gives you such a clear grasp of what is happening. Thank you.

[@Loveisthylaw777]

I have a totally different and unique perspective of cell bio and science in general after watching this video just stunning

[@voiceofreason162]

Seems King David was right - he was fearfully and wonderfully made. Psalm 139. It goes.. For you created my inmost being; you knit me together in my mother’s womb. 14 I praise you because I am fearfully and wonderfully made; your works are wonderful, I know that full well. 15 My frame was not hidden from you when I was made in the secret place, when I was woven together in the depths of the earth. 16 Your eyes saw my unformed body; all the days ordained for me were written in your BOOK. The language of DNA, knits a human form using the instructions of a book. So says the Bible. What a coincidence. Hats off to the animation technicians who transposed the science into this visual dynamic. Bravo. We live in privileged times to see this process firsthand.

[@Siddhartha040107]

Just an interpretation. Doesn't prove anything.

[@chrisschutte3604]

@@Siddhartha040107 smh

[@nickkerinklio8239]

Average Protestant interpretation lol. Take a verse as being literalistic, ignore the original Hebrew/Greek meaning of the words, then tie it in to modern science, leaving any possible spiritual meaning out in the cold.

[@voiceofreason162]

@@nickkerinklio8239 sepher: a missive, document, writing, book Original Word: סֵפֶר Part of Speech: noun masculine; feminine; noun feminine Transliteration: sepher Phonetic Spelling: (say'-fer) Definition: a missive, document, writing, book NAS Exhaustive Concordance Word Origin probably of foreign origin Definition a missive, document, writing, book NASB Translation Book (47), book (79), books (2), certificate (3), deed (6), deeds (3), illiterate* (1), indictment (1), letter (14), letters (15), literate* (1), literature (2), read* (1), scroll (6), scroll* (3), writ (1). Brown-Driver-Briggs סֵ֫פֶר185 noun masculineIsaiah 29:11 missive, document, writing, book (probably ancient loan-word from Assyrian šipru, missive, message DlHWB 683, Tel Amarna šipru, šipirtu, id. WklTA Gloss; √ šâpâru, send, send message or letter DlHWB 683, Wkll.c., whence also sâpiru, writer, and (perhaps) ruler, šapirûtu, rule; see HomAufsätze (1892), 34 BuhlLex 13; perhaps compare Arabic go forth to journey, II. send on a journey Lane1370; Late Hebrew סֵפֶר = Biblical Hebrew; so Aramaic סִיפְרָא ; Christian-Palestinian Aramaic SchwIdioticon 64; Arabic ); - ׳ס absolute 2 Samuel 11:14 +; construct Exodus 24:7 +; suffix סִפְרִי Exodus 32:33, סִפְרְךָ⁠ Exodus 32:33; Psalm 139:16; plural סְפָרִים 1 Kings 21:8 +; - 1 missive: a. letter of instruction. So, a Book of Instructions on the formation of his body. Per the Hebrew.

[@christophgouws8311]

​@@Siddhartha040107neither does your unbelief prove anything.

[@whitehorse1959]

Two atoms walk into a bar. "Damn, I lost an electron" says one. "Are you sure?" asks the other. "Yes, I'm positive".

[@johnsmith1474]

Well in fact you are not a lost electron, you are a positron.

[@coppersalts]

@@johnsmith1474 No, the electron is negative; it's the atom that lost the electron that's positive.

[@johnsmith1474]

@@coppersalts - I read the joke wrong. I was thinking "A lost electron says it's positive ... so it's a positron!" My point was that the anti-particle of the electron is the positron.

[@Toncor12]

Is that Dave from U-Drive?

[@OneDirection2V]

* crickets *

[@petevenuti7355]

They didn't have computer graphics when I was a kid, I read most of the issues of 'science' magazine, and other journals from the 60's & 70's , much of this was still a hypothesis and epigenetics didn't have a name and my teachers were trying to teach that the histones *were* the genes... My visuals, my mental model looked more like a Vetrix game (video game system from the 80s, vector graphics) , I couldn't remember enough at one time to have this incredible level of detail!!! This is GREAT! What did I miss in the last 40 years!!!

[@blueberry1c2]

This is like an amazing combination of chemistry, computer engineering, and mechanical engineering. Perfect

[@naomisbrainjunk578]

I just thought about it and how in some of these animations each little sphere is an atom and WOAH…the body has so many ways of keeping itself alive, and it’s just happens cause we have specific compounds to react to specific stimuli, so we’re really just this huge self regulating meat machine and I know I’ve already come to that conclusion but like thinking about the full complexity of it all is super cool :0 and this video doesn’t even cover a fraction of all the stuff that goes on

[@ic7481]

Designed by the Greatest Engineer of them all

[@alfaestudiomusicalalfa4179]

The music is loud.

[@speed7193]

Yeah these people had no idea what they were doing when they made this movie. Veritasium made a video of this and it's great. I can see there is a culture of poor quality and general stupidity in America now.

[@theb166-er3]

Solar fields .... CAN NOT BE LOUD ENOUGH! :P

[@AA-dv3ie]

I had trouble listening to the explanation

[@merylslabbert3570]

Awful choice of background noise -- totally unnecessary when the whole visual story is riveting and needs a spoken narrative!

[@TurtlesAllTheWAy]

the sound effects are louder lol

[@FutureAIDev2015]

So DNA isn’t just packaged into a coil. It’s a coiled-coiled-coiled coil.

[@williamchamberlain2263]

There's a crazy long length of it in every nucleus: needs a lot of twisting to coil it into available volume

[@monywehat]

pretty much

[@anand.suralkar]

Sums it up

[@renatoigmed]

its a zip file zipped into a rar file and zip it again

[@potatosenpai9301]

@@williamchamberlain2263 2meter in each diploid cell

[@mgmartin51]

Hard to believe that this whole process doesn’t screw up more often than it does.

[@adamb7088]

This is the hand of God and only a micro biologist or a mathematician could understand the writing coming from such a hand.

[@macdermesser]

Truly amazing that these processes, until recently on the frontier of mystery, are now so well understood that they can be visualized! What a testament to nature itself and human intelligence, which has unraveled the mystery! The collective brain power that resulted in this achievement is truly awesome!

[@kennethbransford820]

And yet we still have wars and destroy the planet and lie to one another.

[@kennethbransford820]

@saladdogger Exactly, and there is the problem.It is like there is a campaign against the designer and this knowledge is being suppressed by our invisible enemy Satan the devil himself and wants no one to know that JEHOVAH god himself did this and that Satan the devil does not exist. You can not fight Satan the devil a man-slayer if one believes he does not exist. John 8:44 There is hope thought only if you pray in his name. We are to weak to fight him.

[@markrymanowski719]

It's a testament to God.

[@crazykirsch]

@@kennethbransford820 Satan cannot exist nor have any power unless "God" willed it so. Solve the question of evil and Epicurus' paradox and then come back. Your "God" would be responsible for every moment of suffering in history and future because good and evil CANNOT exist when a creator is both omniscience and omnipotent.

[@kennethbransford820]

@@crazykirsch I never said anything about Satan.

[@ariscottle3542]

This is beautiful. To finally have a video which encompasses all of these processes together is just amazing!

[@pacificstatesofamerica]

As a Principles of Biomedical Sciences student this is so useful! Thanks!

[@eltocatimbres]

im glad Im not the only one who is mind blown by this. this is just so fascinating to see how little tiny creatures move inside your cells delivering information at super high speeds

[@chriswesley594]

A stunning video but the music is far too loud for the narration.

[@daveg5857]

Just amazing. This is a semester of biology in 20 min. It's mind-boggling, and it's like seeing the first images from the HST.

[@huffari]

Truely mind-blowing. Soo amazing! and the micro-creatures walking along the microtubule fibers with the kinetochore. Just made me smile the whole time. Thank you for this. This needs to be in all schools teaching cellular science.

[@petevenuti7355]

Better without the sound, without sounds it's like muppets at work, with the sound it's like hungry aliens....

[@robo7921]

The music is too loud. should not dominate the narration.

[@theb166-er3]

No one said you have to watch this ...

[@moonontheman1103]

and no one said you should deter meaningful conversations, *The B1 66-ER*

[@theb166-er3]

@@moonontheman1103 You are right ... I try not to!

[@piranias]

​@@moonontheman1103 you are one that clearly trying to "deter meaningful conversations".

[@anand.suralkar]

True

[@DerDoenerInMir]

This video got me high, the body truly is a temple

[@aomarmian]

As a mechanical engineer, I used to think engines, computers, cars and production machines were amazing and really complicated. Amazing knowledge needed to create something like this and way beyond the human mind.

[@SMVK]

eah man, that's incredible hard but incredible awesome 🔥

[@raulhernannavarro1903]

Nature does not use knowledge, nature uses competition for survival. Of course it is beyond the reach of the human mind, we evolved for a medium world, the very small and the very large escape our innate intelligence, but thanks to science we have a method to overcome our limitations.

[@aomarmian]

@Raúl Hernán Navarro depends on whether you believe in a creator. Nature, for me, is another term for the work of our creator. Just like I can't imagine my mobile phone being created after billions of years without some intelligence guiding the process of manufacturing it.

[@markrix]

Haha get it? Cellular phone... Rimshot

[@jamesremi6585]

​@@markrix I get it!

[@porshahunt]

would be a great video if I could hear it.. background noise is way to loud in most parts

[@AronAroniteOnlineTV]

I drew this picture when I was kid and later became a doctor for 20 years.Ive never seen this in actual motion except few clips of cell division. Its truly amazing. Thanks.

[@alexanderkorol677]

which picture?

[@Zerpersande]

WTF???

[@daveachuk]

Great video! I've seen some of these elsewhere before, but cool to see them all compiled together. Big Solar Fields fan too, so that doesn't hurt :) Good stuff, keep it up.

[@hitalojta]

Unbelievable. Makes me wonder how the first cell came to be, how did it know how to do all of this. This is beyond mind blowing. Life sure is a mystery.

[@ashiqerasul8062]

Mashallah karim our creator has creat all creation get know him how he fullfeild our needs 💙❤💚💛💖👆🎯🐜💯

[@andrewsair4160]

That’s why it took a billion years just for the chemistry to get worked out by evolution

[@bas_ee]

They think the first proteins (building blocks of life, thus the first life) was created in underwater extreme high temperature/high pressure thermal vents, material (These vents are high in carbon and hydrogen.) getting so hot and violently mashed together, to initiate key reactions for making life. Even today those vents have very rich ecosystems., Its Interessting, because a sceintist also created organic matter from non-organic matter, using the same method: "Abiogenesis by way of hydrothermal vents continues to be investigated as a plausible cause of life on Earth. In 2019, scientists at University College London, successfully created protocells (non-living structures that help scientists understand the origins of life) under similar hot, alkaline environmental conditions to hydrothermal vents."

[@bas_ee]

@@ashiqerasul8062 Thanks but no thanks. Ill live my life how i want (respectable and kind towards others). When im dead who knows. But im not living a slave's life

[@moroccandeepweb5880]

@@bas_eeSome people are slaves to their past, to their desires, to lust, some are slaves to piling up money and property, some are slave to women, some to fame, some are slave to proving themselves throughout their lives. You know life is complicated.

[@devamars]

THE BEST ON THE WEB LOVE THESE TYPE OF VIDEOS AND THIS COMPLEX SUBJECT THANKYOU FOR THIS

[@wendysimpson1211]

I would love to know more about how epigenetics works. Is this what is involved during embryo development... to direct what kind of cells get produced at what time? How those cells are organized into organs? Just so fascinating.

[@iamra8826]

Am I the only one who enjoyed the music and thought it worked well with the video?

[@eyescreamcake]

I like the music

[@Puleczech]

It's good and works well, but is way louder than the narration, that's what people complain about.

[@MLGJuggernautgaming]

Yeah its just mixed way too loud.

[@alejosky]

No, you are not :)

[@matak99]

i agree. Educational vids without constant narration need something in the background. But it needs to be easy to process, like the music in this vid.

[@greggrobinson5116]

To think that what's going on effortlessly in all my cells is way more amazing than my entire macroscale life.

[@ModMINI]

I feel like something awe inspiring happened if I remember to take out the trash and put air in the car tire!

[@Roedygr]

Very good. Explained cell division in more detail than I have ever seen before.

[@richardshalla]

Mind blown, boom! Some of the sound effects could be toned down while others were unsettling and distracting. Overall I am in awe.

[@FutureAIDev2015]

I just thought of something awesome. DNA can be compared to a computer's ROM in that it can be read and parts of it silenced, but usually the information itself cannot be modified by the computer / cell.

[@martino6172]

Looking deeper there is also RAM - methylation of DNA act as RAM it temporary patching DNA to store pieces of information - about biological age, which functions should be not performed anymore etc. Before day 0 of new baby methylated DNA of mother and father ongoing demethylation to reset all this information and baby DNA is ready to start the whole program from 0 using only a little mixed 'ROM' data while RAM is reseted.

[@gelatinocyte6270]

@@martino6172 No. That's not what methylation does. Methylation limits/prohibits the attachment of certain proteins to genomes, therefore suppressing it. It is one of the mechanisms of epigenetics. I mean it doesn't "store information", it merely just deactivate certain sequences or even an entire chromosome.

[@gelatinocyte6270]

By the way, OP, you're wrong - cells *can* modify its own genetic code by itself. Just look up "Transposable Elements" (DNA sequences that can relocate to different parts of the genome) and "CRISPR" (not the genetic modification/Cas 9 thing)(DNA sequences that prokaryotes add to their genome to defend against bacteriophages). DNA isn't really like a computer's ROM/software since there are other factors that affect genetic expression - not just the genome itself. Other than (de)methylation, there's also RNA interference, and epigenetic proteins that either suppress or promote a gene's expression. It's called epigenetics. Tl;dr: computers and cells are not exactly analogous; at least not one-to-one/perfectly.

[@johnferguson2039]

I remember learning about mitosis in high school but we didn't have the computer modeling. Amazing with the newer advances in science.

[@mook5tar]

Really glad thats involuntary.. just couldn't bear doing it on a Monday morning getting ready for work.

[@alexanderkorol677]

doing what exactly?

[@marcelofolhas]

loved it! it's fascinating and educative; great for using it at university presentations

[@whitefeatherbean7429]

Molecular biology has never been as enlightening as now with these fantastic and accurate animations: I love the music...

[@ptrvideo]

Incredible animations, the music is a complete distraction, too loud and unnecessary. Can you post a version with narration but without the music?

[@dannichols6261]

YES! And have actual *narration* captions, at least partly so that if some of the people who made the animation think that the music & sound effects (the bubbling water is the worst!) are in some way useful, then viewers who want to could mute the sound & just read the captions. As you say, this is *otherwise* superb!

[@davidinmossy]

Amazing YOU are doing all this right now and until recently we had no real clue it was even going on.

[@kennethbransford820]

No clue what was going on?

[@naturegirl1999]

To think that all of this is happening in every cell is just amazing. I think the original commemtor meant that before we didn't know EXACTLY what happpened in a cell.

[@deezynar]

No, I am NOT doing any of that stuff. I couldn't do it, I don't have any idea what needs to be done, or how to do it, and I can't see any of it, or manipulate any of it either. I am not responsible for it. This body that my mind occupies is doing those things without my knowledge, guidance, or even my permission.

[@Wd40RecklessEngineer]

@@deezynar Very late reply, i know. But that all boils down to your perception of "I". You're not knowingly beating your heart,growing your hair,blinking your eyes, but its still you. If you want to narrow down your human experience to only your conscious processes then you are only identifying with a very small part of your brain. Do you see how this could be perceived as ignorance ?

[@deezynar]

@@Wd40RecklessEngineer I see how you and I see things very differently. You are free to prove your point by stopping your hair and nail growth. But you isolate yourself from that being evidence of your point because you claim that you don't have to be in control of those things for them to still be "you." With your logic, you could claim that your neighbor was also "you" because you don't control him either. In law, your body is you, but that's because we can't take the two apart without harming the mind, and usually the body, as well. In daily life, the majority of people understand that our body is just a vehicle that we inhabit. The body needs us to provide it with basic care, but otherwise, it does millions of activities within its cells that we are completely ignorant of, and have no direction over.

[@teddytoynton6953]

re up load this with no music g

[@sweetyroy4339]

You have option, either mute or slow ur voice...🤦

[@treich1234]

How the hell does "inanimate" molecules "know" how to precisely transcribe RNA from "inanimate" DNA unless life itself is orchestrating this complexity? So what is this astounding animation we glibly refer to as life?

[@zachreyhelmberger894]

This is the hand of God, YHVH. No amount of wishful thinking could ever design something as amazing as this. No amount of time could ever cause something like this to just spring out of a soup of a random mishmash of jiggling atoms and molecules. The ATP synthase AND the DNA code to manufacture it?!

[@benzene_sandwich]

Please study the formation of phospholipid liposomes. They are what allow for RNA to form and self replicate via ribosome catalysis in a non contaminated environment. These can and have formed spontaneously around water droplets. This has been replicated thousands of times in a laboratory setting. I advise you find a better argument to use for creationism.

[@coolworx]

It feels bizarre that all this is taking place within me, to create me.

[@cjlee8389]

I'm going to say this right now and I mean it in the most respectful way possible. You would have to be an arrogant fool to see this kind of video and believe it all happened by chance.

[@FedorVinogradovGoogle]

Music is too loud comparing to voice.

[@misha1d1]

Who are the 179 people who disliked this? This is absolutely amazing and awe inspiring.

[@jasonwiley798]

Creative designers

[@fecchifreya]

Whaaaaowww what a animation and music and sound effects and science! I love everything in this video!

[@MrMichaelSStuart]

This is beautiful and educational and wonderful!. (But maybe the music and background sounds could be a little less loud; I want to hear the narrator clearly.)

[@martonjuhasz1544]

i was able to endure the loud music and sound effects for 4,5 minutes. the narration is way too quiet

[@fillinman1]

which came first? The genetic instruction or the organelles that read it?

[@gooddouble2]

Nobody knows, but one possible answer is that life started with an RNA-world. RNA can store information and also catalyze chemical reactions. So the same molecules might have been able to hold the genetic information and catalyze its replication too.

[@gelatinocyte6270]

The genetic instruction came first

[@djand77]

@@gelatinocyte6270 The language for the genetic instruction came first. Without the language, no instruction is possible...

[@BLUEGENE13]

@@gelatinocyte6270 good double basically gave you the answer, the RNA world is the best idea, and is VERY compelling because RNA is both genetic instruction and protein/enzyme meaning a small world of just RNA can contribute to it's own survival and replicate itself, which already been shown.

[@gelatinocyte6270]

@@BLUEGENE13 Wait... aren't RNAs basically genetic instructions, at least primal? So it's wrong to say that the genetic instruction came first? I'm curious...

[@dtmsolid1234]

Updated version on TED better quality to understand the information helps a lot!

[@VoidHalo]

Would be better without the spurious sund effects. I doubt there's much of any sound at those sales. It was distracting.

[@anthonyae]

That is well designed.

[@KingJangOng]

Its so cool seeing things so realistically

[@javiermachin1]

Life is such a wonderful mystery. Make the best of it.

[@natura808]

McDonald’s or Burger King?

[@andvokslife9596]

I thank the Lord for your wonderful invention, I pray that many may glorify you, the Lord and our God!

[@daikucoffee5316]

@@andvokslife9596 No just evolution.

[@daikucoffee5316]

@barnyard No one. Matter just follows the laws of physics.

[@daikucoffee5316]

@barnyard Why would you assume they were created by someone?

[@godwho5365]

This is a fricking work of art!

[@twojtwoj2051]

how is this sooo good from the song selection to animation. i have no clue of science but this really got me interested in science

[@goosecouple]

What is the error rate at which these machines copy the DNA?

[@alexwhite8040]

Настолько мала что мы живы )

[@thanesgames9685]

There are enzymes and proteins that function as proof readers - in totality, there would be hundreds of proteins hanging off of the DNA to do different things to meet the needs of the cell. Where there is a mismatch in the base pairs (say a C matched up with a T), the helix is imperfect in a way the proofreaders can notice as they go along the chain.

[@redtails]

1 per 10^-6 to 10^-8. not that great. though that's just copying, after copying there's many checkpoints and repair.

[@Novak2611]

kzbin.info/www/bejne/rIGbXmh4nclll8k

[@CarFreeSegnitz]

While the error rate is fairly high the consequences of errors tend to be very low. The most common consequence is that a cell becomes senescent, alive but not performing useful work within tissue. Periodically death could occur but more commonly death is pre-programmed aptosis, the program ends and the cell "goes into retirement/death". Only very rarely do errors come with significant consequences as happens when an error (mutation) occurs that cascades down to the reproductive organs of multicellular life, then the error could be passed to the next generation. It's on these errors that evolution by natural selection can act.

[@rommelalberan5508]

its a shame such collection of good videos are edited with such poor sound editing, there are at least 3 sounds that mix togheter in a horrible way: Bubble or water sounds, Bjork music and the narration, WHY YOU DID THIS? Its a mess to understand the narration that is a bit complicated sometimes.

[@PlayMoreLoud]

lol

[@amazingpowers6056]

I like it.

[@DarwinianUniversal]

I think the audio adds something important for this presentation.

[@Mountchoirboy]

We cannot be sure what kind of music these molecular machines listen to. Bjork is just as good a guess as any. Seriously, I wish youtube was around when I was taking AP in nursing school. This brings the theory to life

[@grahamhurlstone-jones5664]

Solar Fields go listen their music.....its fantastic......To me the music fits beautifully. I promise you you will enjoy them.....

[@sarahs5340]

People are cracking me up in the comment section completely tripping out on this. Lol, why? Anyway, peoples’ reactions are funny. We are more than our chemistry, or our biological process. We are more than a biochemical machine, but it is truly amazing to see it animated and to realize these processes are taking place by the billions and billions in our body all the time. We are literally existing in the process of creation.

[@adamscottprice]

Incredible video/videos: amazing how much detail we've discovered and how complicated it is!

[@sachinbhartiya4293]

fantastic video

[@1733397574]

Perfect stoner videos

[@Valentine350z]

ikr

[@nxxxxzn]

need to grow me some stones man

[@bucklesmagee3806]

Pink Floyds The Wall brought me here. I like it.

[@anand.suralkar]

Yes gets me everytime

[@paulwary]

Yea who needs the Mandelbrot set when you have molecular ballet.

[@gerardmoran9560]

I only made it 4 minutes into what looked to be a fascinating video. I grew tired of trying to hear the narration which was buried under the music and sound effects. Please remix or adjust!

[@Tadesan]

Amazing video! Bad sound engineering. I suspect the problem is that whoever did the mixing had garbage speakers. It sounds passable on my cell phone.

[@Tapecutter59]

The audio is terrible, the visuals are mesmerising.

[@richardlockhart4557]

Astonishing. The level of order and precision and complexity . . . in what looks like it should be pure chaos. And in every cell, millions. The sound effects were hilarious, esp at the beginning with the clanking and grinding noises.

[@amooser5839]

please tone down the music and effects ...otherwise fascinating video

[@phataton8206]

Random Human #1: How’s life treating you? Random Human #2: well, I’m getting by. DNA: hey, a little credit here?!?!?

[@potatonoodlebear8035]

Paul Hatton lol

[@Charger319]

proteins and enzymes should get credit too. Smh

[@mattsoutback59]

Im glad I found this small little thread..... may it get pinned one day

[@studygodsword5937]

@@Charger319 so you're giving the creation the credit, rather than the Creator ?

[@neomt2]

Amazing animation and narration...but those sound effects tho...XD not to mention that 80's metronome background music

[@cellvisuals]

As an aspiring biotech visualiser, this is still an ultimate pinnacle of scientific visualisation

[@AA-gl1dr]

Thank you for your beautiful work of art. This continues to reinspire me.

[@jeffrusteen6808]

Your background sound is WAY too loud for easy listening.

[@rolandovelasquez135]

"... I am fearfully and wonderfully made; Wonderful are Your works... Psalms 139:14

[@benb3316]

Really awesome! I've been interested in biology all my life, studied it for a while in college. Love how modern computers help visualize it. I think (hypothesis, loose but serious) that there is: 1 - an "Index" function, probably in the wrapping balls for quick ref so there can be commands that call for other commands 2 - memory - that the genes have sections (in what we consider legacy/dead/virus remnant DNA) where they can change the code to remember things 3 - RAM - that there's some things that store floating point memory - such as a tally of how many of this or that protein made so far, what to do if - based on learning - elsewhere in the cell - likely inside and outside the nucleus. Again chemical/mechanical like the rest of the cell versus electronic like a computer. Pretty neat that we run on for all intents and purposes a "Difference Engine" - a mechanical computer - just one of such precision and complexity to be far beyond what Babbage and Verne could have dreamed.

[@metipallearuna223]

Cell versus electronic molecular version of computer animation is fascinating. I'm wondering what would mis -sense 3-D protein of an ant cell having false walking legs attached to an antenna animation look like, for instance.

[@scrambo6182]

It's not quite what you were talking about, but there's a channel called NanoRooms that talks about cell biology in terms of mathematics and programming, leaning more mathematics.

[@benb3316]

@@scrambo6182 I think our systems have more memory than just sparks in the neurons. Instead of one neuron = 1 byte its more like 1 neuron = 1 computer at least in the range of a 128 Kilobyte Apple 2 and again some kind of chemical deep storage - both in RNA piles and maybe some things permanent DNA - Again what now is written off as ancient legacy like how to grow a fin and gills or damage from viruses that got hidden behind ignore flags might be some kind of deep storage system. A hypothesis of course. However ever have a memory come "Flooding back to you" like you didn't have access to it and then you can almost feel the blood flowing in your brain? Being woken up still groggy then getting alert is a good other example. I think there being piles of chemicals that store things getting accessed explains it better and the system is already (DNA/RNA) built on it.

[@SuperMan-nk5bq]

amazing, such a privilege to watch and learn this. work of art thank you.

[@kenwelker7472]

Stunning, mind blowing amazing. I have known the details before but to see them in animation and described is breathtaking. Intelligent Design wins!!!!

[@VyseAcher]

So, not a biologist, here. Where do the small parts get the energy to do their motions? Do they burn a fuel, or are they pushed by physical motions within the cell? When I see animations of molecules walking along microtubules, they seem to be moving under their own energy, but where is their fuel? The only thing that makes sense to me is that their nature is to go easily in one direction and resist motion in the opposite and then they are actually pushed by fluid movement in the cells. Is this correct? I don't understand the energy source/transfer aspect of this process.

[@JamesTyrwhittDrake]

There are two energy sources for the movement of molecules. One is 'brownian motion', the random action of particles bumping into each other. This is a simple consequence of heat, or due to the transfer of momentum. Brownian motion gives rise to the 'wiggle' of molecules and allows them to bump into each other, with enough random interactions enzymes can find their targets and perform biological functions. The second energy source is more 'intentional', it is an energy currency called ATP, which is manufactured from sugar by mitochondria. ATP is a high energy molecule, a nucleoside base with three negatively charged phosphates attached. Because the phosphates repel each other, ATP contains a lot of potential energy. Many proteins, such as the kinesin that moves on a microtubule, have a binding pocket for ATP. When ATP binds to the protein, one of the phosphate bonds is broken, and the chemical energy is transferred to change the protein conformation. This is the mechanism that can give rise to directional movement or actions that have an energy barrier and would otherwise not happen frequently.

[@VyseAcher]

Thanks, James. I was aware of ATP, but it confused me to not see any ATP pictured in the kinesin animations. Thanks for the low-down.

[@gusbisbal9803]

The reason you didn't see it is because it is part of the general soup that is the cytoplasm of the cell. All of that is happening in the medium of water as well. That is not illustrated because if not it would be like making air colored. You wouldn't see anything. The ATP basically is transferring a high energy electron to the protein, it changes the bond orientations and that is what makes the legs "walk" its a change from an sp2 to an sp3 orbital for example and they have different geometries so that change in shape flips one leg over the other. Amazing isn't it. Just amazing.

[@jennywilson4593]

am pretty sure the ATP is actually split inside those little molecular motors - they are ATPase enzymes - similar happens too with muscle contraction - with actin and myosin

[@moonrules7365]

Totally amazing, Gus! It's very, very hard to believe that this is the result of evolution.

[@christat5336]

How many people have destroyed their minds to figure it out...

[@ronniet71]

That was amazing!!!! Thank you. Abstract to me in school. Now I can see those concepts in real time.

[@Seehart]

I love this video because of the detailed physical depiction that is completely missing from typical symbolic animations of DNA replication. I'm particularly interested in the helical motions involved. There is a particular mode of helical motion which is analogous to a standing wave. I'll refer to this as standing wave mode or SWM. This is the motion of a corkscrew entering a cork, and is characterized by the illusion that the corkscrew is not moving (because the lateral motion is exactly matched by rotation). In the video at 9:00, the DNA exiting the polymerase on the right (the leading strand) exhibits SWM, but the original DNA entering the helicase is not portrayed as SWM. This seems very odd to me, since SWM would be necessary unless the covalent bonds in one of the stands are being broken and spliced at each rotation, which seems rather improbable. I also note an inconsistency: at 9:55 the DNA exiting the leading strand polymerase is not portrayed as SWM as it was in the 9:00 scene. I'm aware that the video sources are different, nevertheless one must be more correct than the other. My hypothesis is that the animation is inaccurate in it's depiction of helical motion. All of the key locations should portray SWM, especially at the entrance. Am I right? Am I correct in assuming that the helicase just separates the stands like a zipper and the strands (the phosphodiester bonds) are not cut and reattached once per rotation? I'm interested in comments, particularly after you geometrically understand exactly what I mean by SWM and why it matters.

[@michaelcox5166]

Brilliant but the sound effects really detract. They sound like my stomach after Mexican food.

[@alexanderkorol677]

No, they make it more immersive, it feels like I'm actually there

[@theultimatereductionist7592]

The differential equations that govern the motion of all molecules are amazing!

[@goognamgoognw6637]

I used to think this too, but differential equations are only descriptive tools. Correct within their definition but only descriptive. The universe is solving no different equation to move a wave of water molecules on the ocean. The reality is the realisation of these equations. When you have reality it solves itself.

[@yeahkeen2905]

At one point I swear to god I was hearing Terraria music.

[@DaRios_Tristan]

يا سبحان الله الخالق المبدع المصور ماشاء ركب ♥️

[@BornToPlant]

loving this sound design

[@nickush7512]

Might have been an interesting watch if not for constant invasive background din.

[@bill20061946]

Mind numbing that this takes place. Mind numbing music that kept me from watching more than 1/3 of it. Mind numbing that whoever produced this used mind numbing music. (I think it brought to a stop every DNA transcription in every cell of my body for the time I endured it.)

[@banjo304]

I'm only ten minutes in, but I love the mix of electronic with western guitar. Different strokes for different folks, I guess.

[@cynthiao.543]

What a creator we have...

[@augiespendley3389]

were the sound effects really necessary

[@keithwhitlock7021]

WOW!!!! The complexity is out of this world!!!

[@alexciocca4451]

Don’t need the background noise can’t here the narrative because of it otherwise could be good

[@SirPonchooo]

Why all the sound effects? Why so loud?