The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks.
#Aging #DavidSinclair #Longevity
Thank you to our sponsors:
Athletic Greens - athleticgreens.com/sinclair
InsideTracker - insidetracker.com/sinclair
Levels - levels.link/sinclair
Our Patreon page:
/ davidsinclair
Lifespan book:
amzn.to/3sUqurT
Dr. David Sinclair Social:
Instagram - / davidsinclairphd
Twitter - / davidasinclair
Facebook - / davidsinclairphd
Matthew LaPlante's Social:
Twitter - / mdlaplante
Timestamps:
00:00:00 Introduction
00:03:14 Goal of the Lifespan Podcast
00:07:11 Acknowledgement of Sponsors
00:10:45 Aging is a Controllable Process that can be Slowed & Reversed
00:16:42 Organisms with Extreme Longevity
00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins
00:21:55 mTOR & Rapamycin
00:24:33 AMP-activated protein kinase (AMPK) & Metformin
00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging
00:35:33 Ex-Differentiation
00:43:30 Measuring Aging - Biological Age vs. Chronological Age
00:49:30 "No Law That Says We Have To Age"
00:50:33 Episode Summary & Key Takeaways - Why Do We Age?
00:54:00 Information Theory of Aging
00:57:59 Aging is a Medical Condition
01:01:00 Aging Myths - Telomeres & Antioxidants
01:01:55 Options for Subscription and Support
Links:
Weapon fragments in bowhead whales - bit.ly/3eP7rqP
Rapamycin extends lifespan in mice - go.nature.com/3F0yud3
Targeting Aging with Metformin (TAME) Trial - bit.ly/3eU9ABk
Metformin improves healthspan and lifespan in mice - go.nature.com/3JSRZbs
Metformin reduces all-cause mortality - bit.ly/3pWNiWc
Reprogramming to restore vision - go.nature.com/335iysI
DNA methylation age - bit.ly/3sUAUYB
Genome-wide methylation profiles & human aging rates - bit.ly/3ETPXnK
Reversal of epigenetic aging in humans - bit.ly/3eUior3
Danish twins study - bit.ly/3eToU13
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

[@Gadinata]

I have been following Dr. Sinclair since I was 33. I am 30 now.

[@MyLongevityExperiment]

😆😆😆

[@jeroenkratsborn5122]

😄😄😄

[@mathew9851]

hahahahha this one sent me

[@genuineculture]

yes

[@bridgetnyambura4634]

Hahaha

[@jimparsons4312]

He takes 1g NMN, 1g resveratrol, Vitamin D, K2, 83mg aspirin, avoid sugar, bread, pasta, skip one meal a day, get your blood tested, don't smoke, avoid plastic, excessive UV exposure, X-Rays, CT scans, sleep in a cold bedroom, do cold exposure, do exercise.👏👏👏👏👏

[@johnmc2362]

Thanks for the info, just have a question about the Athletic Greens? What time/amount does he take of it each day if you know? Thanks in advance ☺️

[@catherinelee9130]

Plus Metformin or berberine for controlling blood sugar

[@RickyConnelley]

So glad he made a podcast! The fact we can listen “for free” to a Harvard professor teach is amazing! We live in cool times for self learning

[@microwaveengineer6681]

The combination of a scientist and a journalist for a podcast is just a match made in heaven. This is gonna be great!

[@Corrans]

I agree! More podcasts should be like this.

[@jeffmiddlebrook5251]

Thank God for leaders like David who genuinely want to help mankind. My wife and I are 65 yo and we want life after 65 to be our active second life not a death sentence. We plan to share this information to whomever will listen and become disciples of longevity.

[@levondarratt787]

Lol 65....that's not even old...most people live til 85 minimum these days, or even close to 100. You talking yourself old at 65, is the problem for not achieving long life if you're not careful. Madonna is 65.

[@jimbeaver27]

Hi Jeff, I am 70 and after 2 years of Keto feel 40 again. I am very interested in all that David says, even though some of it sounds expensive. I highly recommend Keto or other low carb diet!

[@jeffmiddlebrook5251]

@crazywarlord777 thank you.

[@jeffmiddlebrook5251]

@@jimbeaver27 Thank you. We are using the Mediterranean diet as our guide

[@MyLongevityExperiment]

I agree, 65 is not old anymore

[@user-sb9ml1ef4q]

"...we can control aging very precisely at will. We can speed it up as fast as we want in an animal, and even reverse it. So aging is now controllable." What a time to be alive.

[@davidlo168888]

We can't control aging indeed without God's mercy nano-medication. If AGEs (advanced glycation endproducts) can't be cleared away from body, it's impossible for reversal of biological aging.

[@user-sb9ml1ef4q]

@@davidlo168888 god has nothing to do with this

[@davidlo168888]

@@user-sb9ml1ef4q Shut up. You don't know. In front of me, prof. Sinclair doesn't know how to reverse biological aging because God doesn't guide him. Do you know who I am? Do you know nano-medication. I've applied nano-medication to cure: Central Pontine Hemorrhagic Stroke Taiwan's medical society is so shocked. This is real Regenerative Medicine. Nano-medication is the only AGEs (advanced glycation endproducts) breaker. You go back to home for further study. You're not qualified to come here for bullshit statement.

[@user-sb9ml1ef4q]

@@davidlo168888 you should be taking meds man

[@odmineypiju4761]

I am 27 and in the last few years I began to notice, that some of my peers are aging much faster than me. This observation caused me to often contemplate the topic of aging, and when I listened to Dr. Sinclair on Huberman Lab, I subscribed to Lifespan right away. Thank you for your work and for making this information accessible!

[@MyLongevityExperiment]

I wish I could have started at 30

[@odmineypiju4761]

@@MyLongevityExperiment It's never late to become 30 again :)

[@tappersuzie]

I started taking responsibility for my health in my early 20s. I stopped drinking - have not had one single drink since 1987, no cigarettes since 1993, I've had excellent nutrition and exercise. I have seen the amazing results for years, but now that I'm heading towards age 65, my efforts have paid off tremendously. I look and feel much better than 99% of my contemporaries. And now with all these new developments in knowledge, I benefit still. Something not mentioned by most practitioners too often is faith though. I'd be nowhere without my study of the Bible, years of pursuing that knowledge trumps everything.

[@AnnTsungMD]

@@tappersuzie Thank you for sharing your story and experience. Your story is very inspiring. I agree that faith plays a big role in our overall health, happiness, and longevity - and for me that is the most important THING of all. ❤

[@carl8790]

@@tappersuzie whatever 7 day adventist are doing, it's working for them. On average they tend to live longer than their peers.

[@JumperAce]

The same way you feel more justified in taking fitness advice from some one who is visibly in shape, David is 50 and looks 30, and he's been applying his science to himself. Such an inspiring guy

[@calgaryalberta4892]

Yes he looks younger this time

[@AnnTsungMD]

Agree! He walks the talk. He is visibly in shape. What he says is really worth trying.

[@BrentNally]

I’m stoked David finally has his own KZbin channel! Let’s all work together to solve aging ASAP!

[@SallyEndinberg]

Thanks for all your work too Brent!

[@Health.First.]

Oh hey Brent. Nice to see your comment here.

[@syrupgoblin4920]

Let's end it!

[@jamesgallagher8714]

Love your content too Brent!

[@maspesasmasperras5554]

Let's start with why he applied all botox available in the Northeast

[@callofthedark]

The wait is over.. My guru is Live. No words can ever comfort me to express my gratitude for all that I have received from life especially from my Guru “Dr.Sinclair”. I have been fortunate to have followed you since the past 4 years and all that I can say is that I am a 37 years chronological getting oldman but who looks like a 27-28 years young & health. It’s because of following you and your lessons on longevity I have been able to successfully reverse my biological age to live a robust & active life till a 100. As Dr.Sinclair once said “The one who will live till 150 has already been born”, I will do my best to be among the set of people who do. In the end can’t wait for your new Book and listen to the remaining 7 episodes of this podcast series. I bow before you for all that you have taught me.🙏🏻

[@BlackMamba-lt8oe]

you will be the longest living human in india 300 years

[@Beluinduh123]

Love the dynamic, having someone to bounce ideas and questions about this topic is important! Thank you both for this platform 🙏

[@LongevityPlan]

We’re super jazzed David has his own KZbin channel and podcast now! The future is looking great!

[@zalareverie4745]

I have been counting down and now this podcast is finally here! I am greatly inspired by you and Dr. Huberman and i'll be forever grateful to Lex Fridman to introducing you both to me. Keep changing the world for the better!

[@chrispridemore5562]

Forever grateful, literally. :D

[@zalareverie4745]

@@chrispridemore5562 i see what you did there... or what i did there xD i tip my hat to you :D

[@ioanenikoladze86]

Same bro!!

[@henriqueguarnieri9639]

Same !!!!

[@cecipalacios1007]

Kudos to scientist like you, Huberman and others who brings this wealth of knowledge in a easy to follow format! Lectures like this and Huberman’s as well are priceless. Thank you

[@tonyamckimmy693]

On my last leg of treatment for Lyme Disease. I sincerely thank you and Professor Huberman. Your teachings have given added strength to my hope that helps me carry forward.

[@sneakers_guy5488]

Thanks so much for starting this podcast series Dr. Sinclair! Matt's inclusion on this podcast is immediately evident to me to be a great decision, acting as an audience member (in a sense) asking the questions that many of us would in real time. Great format 👍

[@edison_ryan]

I'm 15 and I'm so fascinated by the forefront research and discoveries in the field of longevity and I'm so glad you started this podcast! Thank you so much, can't wait for future episodes!

[@Edaryion]

That is great! You have an opportunity to start mastering this early on!

[@lckee820]

Good. You are starting young. I only learnt about anti ageing when I was already in my sixties! Anyway I can testify despite only half applied people still think I’m betw 50-60 years old!!! I’m nearly 80!

[@HiTechFX]

I'm 67 and agree with you!

[@markschultz3791]

Wow you're 15! What an accomplishment!!

[@tomsawyer2112]

@@lckee820 So what. at the age of 60 people thought I was at my early 40. I ever smoke, no alcool, an no sunburning, physical training for 50 years, no overeating, it as easy and has nothing to do with taking supplements early.

[@billgarner1195]

David, I would like to personally thank you for your life‘s work and the work that you are doing in reversing biological aging. As one of your students applying the information gleaned from your research to my personal life and to the lives of the medical practices and companies we serve. All I can say is this is a hell of a lot of fun :-)

[@drewmoon3000]

Congratulations on your official appreciated podcast. As an Aussie living abroad, you are a guiding light of inspiration. Thank you, Mate!

[@jenniferdonnelly-montedeoc9285]

I loved your book and recommended it to countless other healthcare professionals. Really exciting stuff! This podcast was excellent. I just can't say enough great things about you and your work. I'm so grateful that you are doing this podcast so that everyone can get as excited about these incredible advancements as I am!

[@ChrisWillx]

Love this. Congrats mate!

[@pauloconnor1857]

I've been so excited about this podcast....Here we go. Love your work David and thanks for bringing us this free information.

[@lotfibouhedjeur]

I'm bursting at the seams with excitement! Dr. Sinclair has an official KZbin channel. I love how assertive he sounds talking about what he knows.

[@luisrodrigueziii7316]

I'm SOOOOOO happy that we finally have a David Sinclair podcast. Please keep this up, I look forward to the future of the show and the science that it'll teach.

[@Borromeo377]

Happy New Year David - a long awaited podcast 🙌🏼Thrilled to find out more in the subsequent episodes. Thank you 🙏🏼

[@wednesday6018]

I'm sure I speak for all of my fellow science lovers when I say, thank you for doing a podcast. It's so exciting! 😊

[@MyLongevityExperiment]

I agree, this is well overdue

[@bredemeijer9648]

yw

[@brittneytan8213]

I can't wait for the next episode. This topic is near and dear to my heart, i want to live forever, or as long as i am able. I enjoyed the podcast, I never knew you're so funny Dr. Sinclair!

[@danovic7822]

Love this! Every bit of knowledge I can get about longevity I'll gladly take. Thank you David, for everyone you do for humanity!

[@farhadkhan5224]

I’ve read Lifespan several times and been eagerly waiting for the latest updates from David Sinclair’s research. So glad to see this podcast.

[@JeffNixonComedy]

This is going to be such a powerful podcast. Can’t wait!

[@MyLongevityExperiment]

I agree

[@ggbrait9406]

THANK YOU!!! This is awesome! Grateful to my favourite members of the humankind, Lex and Andrew, for introducing Dr. Sinclair to someone like me🙏❤️

[@simonfoo8684]

Excellent way to allow layman like me to understand better about the science behind aging. I have listened many of Dr. Sinclair's talks and interviews but this podcast is really well orchestra to enable viewer to better understand the subject matter. Thank you very very much to both of you. I really enjoy watching it and forget to eat my lunch, which is a good thing to miss!

[@Adam-nw1vy]

Dr. Sinclair is a hero. We owe him a debt of gratitude. I have been following him and his work since 2016 like every single week. I'm so glad that there is a podcast now! The only thing that I'm worried might derail this fantastic and groundbreaking research is the political turmoil in the US. We need to make sure that this research reaches fruition no matter what.

[@redpilllense7125]

This is AWESOME! Thank you, Dr. Sinclair, for doing the good that helps humanity. You are God sent!

[@vickydaisy_rose]

Happy New Year Dr- David Sinclair. Thank you for developing the podcast. Amazing contents to be followed.

[@janisgs]

Dr. David, I have been following you for ages already, so happy to see you starting your own Podcast. Looking forward to every moment with you.

[@larmikvonhorshley8631]

I really appreciate Dr. Sinclair and the work h puts into making information so crucial to a long and healthy life available and accessible. The child in me can't help but see The crocodile hunter and The House of Pain guy having a casual conversation about epigenetics. We live in amazing times and are so fortunate that such dedicated people are willing to give so much of their valuable time to share their life's work with the world. I am both filled with gratitude and deeply humbled by this generosity, thank you both so much.

[@colinyoung3685]

Looking forward to following this podcast. May it be fruitful with a long lifespan.

[@minister1005]

So excited! Thanks for doing this! We always needed more ❤❤

[@sammyhoffman71]

So excited about this series, thanks for giving up some of your time to help us extend ours

[@jamescarpenter2384]

I would just like to thank you for your courageous efforts in keeping us all healthy and young if possible. I am sure that your grandmother is really proud of you now. I have been following you for several years now and find that Your explanation of your research is down to earth and clear especially for a nonscientist. I truly do hope that when you come out with formulas for the rest of us to take they will be available to all at an affordable price as you have said you would in past talks. NMN sounds very promising. Keep up the great work looking forward to all of your talks and podcast and once again I👏Applaud you

[@SatbirAulakhMusic]

Thanks again David. Your book has changed my life and life of hundreds of my patients. I work as a GP in Darwin

[@natalieaxl804]

Love you David!! Appreciate all the study and research you do and keeping us in the loop of your discovery 🙏🎊💕 Blessings 🙏

[@WyattFL5]

Dr Sinclair has the rare ability to explain complex science in every day language. He’s absolutely one of my favorites, along with Dr Rhonda Patrick. Looking forward to future episodes!

[@turkishromeo83]

Huberman Lab & Dr. David Sinclar, absolutely the Best of Best 🙌🏼 Thank you so much for sharing all your knowledge for free with us 🙏🏼

[@vladimirivanov6015]

Awesome first episode! Really looking forward to future episodes. This field definitely needs more popularization to change people's perspective on aging.

[@j_grieshaber]

Absolutely amazing. This was more than I had hoped for, so much fantastic, mind blowing information. I cannot wait to be able to test my biological age affordably and often. I am very much looking forward to the subsequent episodes and the upcoming book! Thank you Dr. Sinclair for taking the time out of your very busy schedule to make this happen for all of us, this is truly a gift!

[@divyabhatia9916]

Thank you so much for starting such an amazing podcast and providing amazing information free of cost. You are an amazing researcher, human being and an inspiration. And thanks so much for amazing research you do and for teaching how we can use that information and implement it in our daily lives to make it better.

[@tygrera]

I am so glad that this is happening, I've been a fan for a long time, absolutely love your book, much love from the Netherlands

[@SCP-SAM]

Amazing content! Thank you for starting these! Have purchased the book-which is amazing!

[@Petewalker907]

I have been looking forward for your podcast for a while now and I am happy it is finally here :) thank you and keep changing the world for the better :)

[@fuscialilac3306]

Very pleased that you are going to share your knowledge and experience with us in the podcast format, Dr. Sinclair! I'm looking forward to learning more and working to optimize my biology and be creative and productive for years to come. Thank you!

[@armieflores6064]

I have been following you Dr. D. Sinclair, so excited to hear all brilliant information for longevity and healthy life.Thank you an awesome work with your team and sharing it to us.

[@stevelacy8342]

This was a great podcast, thank you ,can't wait for the next one.

[@volkerhiddemann7236]

Thank you Dr. Sinclair for this insanely insightful work that you provide. It’s a pure pleasure to listen. It makes me smile to whiteness the similarities between your and Dr. Huberman’s podcast, knowing of course that he helped to ramp this up. It’s great to have such powerful people see collaborate. Matthew La Plante brings a nice twist to the topic. Highly enjoyable. Looking forward to the following 7 episodes.

[@lanetteglass8192]

So happy to see this. Been following anything Dr. Sinclair does for a year or so.

[@zafrat5727]

What a time to be alive!!! My Goodness, I am so grateful to be learning this. Thank you Dr Sinclair and Matthew Laplante.

[@dylan8487]

I discovered you thanks to Andrew Huberman, currently reading your book and am hyped for this podcast!. I have a feeling its going to be an amazing one.

[@robertobenedit]

Excellent, first Andrew, now David, life can't be better! Cheers for science! #scienceRules!

[@markd6838]

Thanks for all the work you do, your research, your book and the podcasts etc. It's much appreciated.

[@krevoyteam]

Can't tell you how happy I am that you decided to do a podcast/youtube channel Dr. Sinclair...way overdue in my opinion but I also understand you are a SUPPER busy man and so grateful for you

[@johnjudson8482]

Thank you Dr. Sinclair and Mr. LaPlante for your book and now this podcast. When it comes to health, I feel like I have been stumbling around in the dark my whole life. The context and data that you have structured so beautiful is giving me hope that an actual and manageable path to health is within reach. You guys rock!

[@MyLongevityExperiment]

Very true, so much misinformation there from Governments and commercial organisations

[@vitalrestandrecoveryclinic7752]

Im so excited for this podcast. Thank you!!!!!❤

[@DrGayleDelaneyDreams]

HOORAY! At last, Dr. Sinclair is unfettered by interviewers who feel they need to ask the same introductory questions and he is free to move on to the next level of explanation. Matthew is so well-informed and knows how to compliment David's points and how to ask interesting and useful follow-up questions. The lighting and sound are good, and the introduction to and the updating of the work is well thought out. THANK YOU! I shall be able to share these videos with a much broader spectrum of my friends and colleagues while learning more and more!

[@sleepmeditationsandrelaxat5681]

You have touched the lives of millions and I hope the medical research breakthroughs will one day change the course of humanity for the better. Thank you and I will keep on following your work

[@seeesh_]

I'm so excited. And happy to see your own podcast, David. Greetings from Brazil

[@paulcamdar4170]

This is simply incredible. Thank you Dr. David Sinclair.

[@MyLongevityExperiment]

Well overdue

[@braian4478]

Finally it's here!!, congratulations David and team! And thank you very much for share such a useful information!

[@martinahollearn9538]

'I've listened to all episodes and I LOVED all of them. Dr. Sinclair has a lovely voice for podcasting and it's fun to have the two hosts bounce ideas off each other an guide the conversation. Listening to the episodes have been a major inspiration for my personal and professional life and further motivates me to study neuroscience. Please keep working on new series!!

[@zinkarius7]

Thanks for all your work Mr. Sinclair

[@asad9813]

This is such an amazing thing David has done to fans. It's going to be great!

[@Bolangel]

Mind blowing ! I have been watching videos about aging process for over a year now and I love every one of your interventions - but this is just mind blowing, the first one in which the concret biological process is so clearly explained ! Great work

[@angelasaarloos3991]

David Sinclair is such a bright mind but also a kind human being! I'm so inspired.

[@pareto3568]

Read Lifespan and now listening to this. What a great opportunity to solidify the concepts expressed in the book and be up-to-date with new research.

[@arupkalita2756]

This is the podcast, I have been waiting for so long

[@A7md02]

Can't thank you enough for the huge amount of information we get from you Dr. Sinclair. I wish if the video was supported with pics for what was described.

[@MatoMkenya]

What a way to start 2022. This is epic. Can't wait for the other episodes. Thank you Dr. Sinclair for the info all the way from Kenya.

[@teddy4097]

I cannot wait to see what’s this podcast going to bring to the table! I learned about Dr. Sinclair on Whitney Cummings’ podcast and immediately after I read your book! Fast forward a few days and I decided to study Molecular Science in University to hopefully research aging one day! I cannot express my admiration for you enough!

[@faceyogamegi]

Well done !

[@MyLongevityExperiment]

Great idea

[@YogionaJourney]

Such an educational podcast! Thank you so much for what you are doing 🙏 In your book you mentioned that in Hebrew there is a phrase "till 120" when people greet each other every birthday. We also say in Hebrew "Lechaym" which means "to life" every time we raise our wine and cheers. So, thank you for improving our quality and quantity of LIFE.

[@wanderingstar9322]

I've been meaning to watch this video series for a while and I finally got around to it today. Having watched this first video, it got me excited and I'm looking forward to the rest! Thank you Dr. David Sinclair and Mathew LaPlante for sharing this information with the world 🙏

[@alejandraalvarezdetoledo1783]

Thank you thank you David Sinclair and co host for speaking so clear for us that are not on the scientific world. I was a mother at 44 years so my interest in keeping alive with my best quality possible as long as i can is a huge wish so i can share with my child many things in his adulthood. Hope as what you say, devices and everything else will be more accesible for us in the future, but we can start with what´s in our hands and that i have been reading/listening over the last years and it´s what you talked about on your episode 2 which i loved too. I´m excited for the next episodes!!!!!

[@aussiecfo]

Great kickoff! Looking forward to every week.

[@robertadams3666]

Didn’t want this to end. Look forward to the next one.

[@johncarlrankin479]

Well Done David! I have been following you for years, as you know. Now is exactly the Right Time to help everyone feel better about their future, and the fact that this is All Possible. Looking forward to the next episode! Much Love & Best Wishes Always, brother.

[@sunshinemittens23]

Yeah!!! 🙌 So stoked you are doing a podcast!! Congrats & I’m thrilled to learn, learn & learn some more about health, longevity & more. Cheers! 🥂

[@forcela000]

Wish you good luck with this new endeavour! I've started reading your book recently, so interesting and fascinating can't wait to learn more

[@gautamnandu5420]

Can’t believe it’s happening I’ve been waiting for this for Such a long time. He and huber man changed my lifestyle completely

[@catsteinhilb2880]

Thank you both for this … this is immensely valuable to all us humans striving to live longer, healthier lives ❤️

[@paprikaveg405]

Brilliant , I was looking forward to watching this episode and for the ones to come, thank you 😊

[@Gunrun808]

I eagerly await every Monday for Andrew Huberman's life-changing podcast. And now you're telling me that I get another podcast on Wednesday? Amazing!

[@prisar]

After so much waiting, finally happy to see the first episode came up

[@MarleneYCM]

Finally it is here! Thank you for your Life changing research - Dr Sinclair is a rockstar!

[@ishtar0077]

It's so wonderful to see new podcasts. I'm very excited about it 🤗

[@BetterHumans]

So excited this is finally happening :0. I started your protocol 6 months ago aswell as a few other things and can't wait to start sharing my journey when I get the 2nd bloodtest from Inside Tracker...What I can tell you is I feel incredible....Lets get this train rolling!

[@guitarsz]

Way to go David! I've watched many of your interviews on Rogan, and Lewis Howes and Impact Theory, glad to see you made your podcast! Congrats!

[@liu123]

Thank you for your work and sharing this information. This is truly inspiring and please continue to be motivated by helping humankind!

[@sarah-anneperry6932]

My year's resolution this year is to keep hope alive and this content is coming in handy.

[@dennis200620062006]

Amazing dr Sinclair! Love the work you're doing.

[@SebastianNiemann]

Amazing podcast 🙏❤️- already looking forward to part 2

[@singhashon]

I have been following this research for a while now but everything I hear the science and frameworks around it again and again just makes me more and more excited

[@DavidMedelMacias86]

Been waiting for this forever! Thank you David!