How much of aging is genetic?

[@TheSheekeyScienceShow]

GWAS, more like G-WOW

[@lennihe]

Curious as to why out of 50+ genetic loci identified in the studies, only a few are repeatedly seen. Are the others false positives? Are the studies all looking at genetically homogeneous groups? Are these other loci benefiting certain environments/diets/lifestyles?

[@TheSheekeyScienceShow]

@@lennihe Good questions, some may unique to population studied (& may interact with their environmental factors). Also some studies dont look at the whole genome and have sequence information for only some regions

[@SI-ln6tc]

They know diet is considerable for longevity vs genes alone. They know this through the study of twins. (One eats healthy. The other one didn't.) Genetically both twins are the same but one is living healthier or longer than the other.

[@StuJones-gn7te]

The under feeding experiments of the 1960s and 70s and the subsequent calorie restriction studies after that, show very strongly that diet is a significant (possibly primary) determinant of aging. Far more so than any genetic effect. I've known several people to live to 100 or close and almost none had kids that lived as long. I've also known people who had parents who died very young from natural causes, yet they lived to be very old. I'm not convinced of any genetic effect on lifespan.

[@JohnnyRocketone]

Can you talk about Fads2? Snp

[@mahadib.alyami8606]

This is one of your best videos! Thank you so much for such a wonderful, educational content. 🙏🌹

[@WorthlessWinner]

It's a semantic question if it's a gene "for" longevity. I'd say that, if a mutation results in increased longevity, then it's a gene variant "for" longevity, as much as it's a variant "for" anything else. That is, I'd define the function of a gene as whatever it happens to do. You could argue what it evolved for is what it's for, but we rarely know that and it's original function has often been changed over time.

[@adishgupta7503]

Good man, nice work done and thanks for explaining beautiful in simple words.

[@Nanoukdelest]

did you change your mic? it's less sharp it's great ;)

[@TheSheekeyScienceShow]

Same mic, but processed differently glad it's better

[@-w-.]

Keep up the great content!

[@dontmindme5189]

You didn’t cover health-span but I’m sure the factors are similar to what you described here, great video.

[@jordanmeija7384]

🖖Thanks for your information. God Bless You...Live long and prosper...

[@josephjroy6593]

Can gene researchers use a different hallmark of aging other then diseases, for example, the onset of puberty? The transition of a animal from child to adulthood is biological AGING. What are the genes that determines the appropriate age to develop puberty? Are we be able to reverse puberty genetically?

[@Earwaxfire909]

Good question. And now we have many steroids in our foods that accelerate the onset of puberty and chemicals that imitate them that it is worrisome.

[@cipriantodoran1674]

@@Earwaxfire909 I like your point. But I wonder if there is a difference between natural, genetic onset and development of puberty, for example there are people which grow in height faster, and the bad nutrition, as in eating a lot af chicken fed wrongly, and exposure to artificial lighting induce puberty. I believe the second case to be much more detrimental (and this one is not genetic).

[@Earwaxfire909]

@@cipriantodoran1674 Good ideas. It might be possible to study this by noting the age of puberty in a variety of animals and their corresponding life spans. And then testing some animals to see how steroids impact these. Would be interesting to see if C. elegans could be a useful model divided into puberty/age classes this way. For humans it would require monitoring age related factors over a long time span. Might be possible to do statistical analysis of a huge population in a shorter time span. There is your next PhD!

[@cipriantodoran1674]

@@Earwaxfire909 Thanks! Omnivorous mammals should make more accurate models, such as rats, since you can feed them more similar diets as human diets and also determine when they reach sexual maturity. Then correlate the data from the wrongly reared rats with the control group, and human data (both historical and present), thus obtaining some predictions regarding how much is genetics when it comes to human health (or life) span. I hope to finish soon my current PhD, so this subject should be someone's else thesis.

[@StuJones-gn7te]

When they did the early calorie restriction experiments on lab rats or mice, the test subjects were nearly at the average life span for their species, but hadn't yet reached puberty.

[@So1asola]

isnt daf2 for igf1 or am i mistaken?

[@kreek22]

There is a significant correlation between intelligence and longevity in modern humans, even after adjusting for income levels. But, then, intelligence is positively correlated with almost all known heritable traits--except autism and myopia.

[@ismith8053]

I wonder why and how exactly. Smart people aren't necessarily good at handling their lives. They can have depression, underachievement, obsesity, even substance problems and loneliness. Obviously they might make some better decisons eg on health and nutrition and lifestyle choices too. I also wonder, perhaps a smart person can relax and focus the mind in a meditative type of way. That would allow the brain to reset various processes - hormone levels, aspects of the immune system etc. Did you find anything on your reading?

[@StuJones-gn7te]

More likely, the effect is most notable among those just mildly above average. Ie, IQ of maybe 120 or so. But above 140, we get depression, suicide, serial killers and super villains.

[@luckssj]

You need to talk to Dr David Sinclair and get him on your show.

[@ioanmariandanila3452]

I wonder if the DNA repair genes, of which mutations decrease lifespan, could be considered longevity genes.

[@SI-ln6tc]

Mutations usually is bad.

[@StuJones-gn7te]

The only good mutation I've heard of in the real world is the one that apparently prevented people from getting bubonic plague and now seems to block HIV and aids.

[@blast1one286]

Cool video.. I have those foxo3 variants lol

[@ioanmariandanila3452]

If DNA damages cause aging, and if the human zygote does not contain any DNA damage, then how much of aging is heritable?

[@mdavid1955]

There must be some genetic regulator of lifespan, as we live longer than chimpanzees, they live longer than dogs,etc. What genes set maximum lifespan in mammals.🤨

[@StuJones-gn7te]

More likely, its an effect of diet or lifestyle. Chimps have lived to be over 60 in captivity.

[@rejeanorscott1555]

Have you seen literature that connect sex hormones like estrogen to longevity?

[@surfreadjumpsleep]

Heterozygous APOE4. :(. Would be happy for an APOE2 gene therapy pleeeeeeeeeeeeze.

[@kreek22]

I remember a study showing that African-Americans with high-risk APOE genes had significant life expectancy loss, but that Africans in Africa did not show any such loss. Their diets are very different. It could also be other factors.

[@ioanmariandanila3452]

Cancer is the second cause of mortality, and has epigenetic or/and genetic causes. Cancer is an aging-associated disease.

[@troyhayder6986]

Apparently 38 is genetic death...which means im on borrowed time...

[@StuJones-gn7te]

We can only guess, but from all my reading, I'd say exactly ZERO percent of aging past full adult growth is genetic. In spite of literally, hundreds (possibly thousands, if you credit the ancients) of years of research and serious attempts at studies since the 1960s, and increasing efforts every year, there is ZERO credible evidence of ANY genetic aging effect. Therefore, aging is entirely caused by environment.

[@ResidualSelfImage]

Human longevity is quickly shorten by suicide or homicide. The lifespan of different types of a cell will vary depending on it type. blood cell lifespan is different from the stomach lining cell lifespan and the lifespan of brain cell. ... the lifespan on a cellular level may vary on the environment factors. Overall, one can boost general lifespan of cell by slowing down the metabolism and promoting autophagy to get rid of dying cells.

[@ioanmariandanila3452]

Dear Sheekey, why the bowhead whale is the longest-lived mammal known?

[@SlamminGraham]

iz kewl kzbin.info/www/bejne/nmmYfZ94ptOVoLc

[@renatodoe6661]

First

[@seancooper5083]

A longevity gene FOXO3:G