Aging and activating the heat shock response.

[@TheSheekeyScienceShow]

Pretty shocking stuff, eh?

[@kanahn7402]

So, does this support or contest the idea that saunas are good for you? 🧐🤔😋🤪

[@peterz53]

"Details" are good !!! Better to explain more than less.... Thanks for discussing this important topic

[@steveherston154]

As a biochemist I’d say thanks for this overview. My personal tips would be to start off by sketching the core concepts/ outlines a bit more using simple terms before elaborating and diving into the biochemical/ research terms to make this understandable to a broader public, and easier to understand for those with less background knowledge. And maybe a conclusion with a concise and simple take home message might boost the appeal. Also your pace is quite high I think so I had to pause and replay sometimes to really get to the core of this. Otherwise very well done and thanks for the efforts

[@darkhorseman8263]

Boron in our diet regulates certain aspects of the functioning of heat shock proteins, in much the same way its used to insulate electrical wiring in space craft.

[@johannahkatz6127]

I have learned SO much from your channel over the last year while pursuing my masters in nutrition. May I ask what this cool program is you use for these videos for this amazing animation?

[@stevenorton1881]

Excellent. Left me wanting more!

[@fanmengchen2323]

Excellent presentation !

[@TheHammond101]

I might be applying for a research MPhil at the Babraham, atm im working as an intern at an early stage life science VC. Would love to have a chat about research life at cambs, as well as shooting some ideas around novel drug targets, have a couple in mind, would like to hear what you think.

[@robertrowan9893]

I'm certainly more encouraged than becoming actively discouraged by the sum total of the vid's overall message. Here's me been long term drinking pineapple laced black tea and munching on capers for their very quercetin content, blind to the fact that ...Well - we don't know yet! All things considered, with my brocolli and alfalfa seeds reordered just this morning, I'm at the very least bathing in sulphorophane's positive glow, even before I learned of their favourable HSF1 involvenent less than 2 minutes ago. Makes my 36 hour fast that I'm currently engaging in all the more worthwhile...in the grand scheme of things. Two turmeric coloured thumbs pointing indeed upwards in appreciation.

[@bluellamaslearnbeyondthele2456]

Capers ought to have apigenin too. But I couldn't get used to it. What's the deal with pineapple?

[@robertrowan9893]

@@bluellamaslearnbeyondthele2456 Boosts the absorption by a significant factor. Throw in that it's real juice and not the pasteurised variety with the vit C largely removed, it's the business. Also, because there's strong evidence of the combination dumbing down the same interleukins involved with that pesky virus doing the rounds. Again, because they're the real deal and not synthetic analogues that on paper are similar, but in real studies - fall short!

[@joeschmoe5583]

Quercetin has also been shown to inhibit Sirt2, and potentially other Sirtuins as well. It seems though it is a weak inhibitor of Sirtuins, and is stronger in inhibiting NAD competitor enzymes (such as various CD's) and inducing autophagy. The key with quercetin seems to be small doses - while getting apigenin straight from parsely/chamomile, and taking fisetin - along with some fat and other things that increase absorption - should be most important.

[@bluellamaslearnbeyondthele2456]

@@robertrowan9893 ain't quercetin an ionophore too? I could be wrong. I'm that case, that would also help with peskiness provided there's zinc in there too. But I'm confused about why interleukins would interfere...

[@raymondwalsh7520]

Okay so, I'll take your word for it

[@drtechtek2165]

At which Temps´ are they activated?

[@TheHammond101]

Great vid sheeky!

[@TheHammond101]

I might be applying for a research MPhil at the Babraham, atm im working as an intern at an early stage life science VC. Would love to have a chat about research life at cambs, as well as shooting some ideas around novel drug targets, have a couple in mind, would like to hear what you think.

[@mazedmarky]

heyy, thank you

[@viracocha2021]

So, if we want less HSP, why saunas are healthy? Do they help to have a more reactive HSP response instead of a high basal one?

[@TheSheekeyScienceShow]

Yeah, so that is a great question that i don't think we have the mechanistic answer to yet. As i mentioned it would be good to have more biochemical/transciptomic data on the heat shock response including saunas

[@raychance9696]

@@TheSheekeyScienceShow > Yes. Terrific question. I use a sauna everyday along with exercising. There is a 40% decrease in ALL CAUSE MORTALITY for men who use the sauna 5-7 times per week. zachpartin.com/cardiovascular-and-other-health-benefits-of-sauna/ If sauna use was a drug, it would make national news. Please provide a follow up to this video. Thanks again Sheekey!

[@Chris-kr7gg]

@@raychance9696 on average how long a day to you use a sauna and do you incorporate a long exercise regime or high/moderate intensity or do you moderate depending on your day and energy levels? Also of a person were to fast for a few days or day would you recommend exercise or not as that person would surely need fuel to exert theirself.

[@rfbead321]

@@raychance9696 same here...I use the sauna almost every day.

[@raychance9016]

@@Chris-kr7gg I try to mix it up prior to using the sauna including weights, treadmill, and VR. In the sauna I do breathing exercises which enhances the experience. I spend 20 minutes in the sauna after the initial sweat. For fasting, I follow prolon FMD for 5 days and do not use the sauna during that time (recommended by the program).

[@allurbase]

Could that be that it's dangerous to exercise under senolytics?

[@lucaskazama878]

another person you could interview: The Bioneer (aka Adam Sinicki). another big name to promote your channel, and reasonably easy to reach. He became known after posting "Exercises that Batman would do", Beyond Sports, He knows very little about the longevity spectrum, aside from trying Intermittent Fasting. The cool thing about him is he tries to make a balance between Functional Exercices (cross-fit, cardio). and Bodybuilding (weights) and mainly: The name of his channel "bionner", is connected to the fact he tries to control his biology, the idea of self hacking, as all we try to do. Another cool thing, he doesn't talk specifically about longevity, but always tries to promote health at any age, and really takes exercises to another level in order to accomplish it. He is from the United Kingdom, and will probably not lose the chance to promote his books and shirts if you allow it. If he says he needs the cachê to be in an interview, tell him he lost the chance to speak to the first immortal doctor (yes you). If you do not buy a Microphone for table, until the next interview, the State of California will receive a big Earthquake.

[@TheSheekeyScienceShow]

Am actuallly subscribed to his channel. I'll bear in mind though not sure how well it would fit on this channel at least at the moment

[@sussybaka9392]

Cảm ơn bạn. rất dễ đọc

[@MikeG-js1jt]

Yes the quercetin question is a little puzzling.

[@NEWMAN1HAAS]

Subtitles to better understand thank you very much I like your channel is very interesting.

[@kamanashisroy]

After going for run, when I am at bed, I feel a low level of fever. Is that activating the heat shock transcription factor ? Could it protect the cells from death ? Could it make the newly transcribed proteins better ? I feel that my pains are gone next day. So is it reducing inflammation ? Finally ,what is the impact on the immune system and white blood cells and stem cells ?

[@Hesacon]

Certainly not too much detail! Don't censor yourself, go into as deep a detail as you find interesting and necessary 🙂

[@TheSheekeyScienceShow]

Thank you!! 😊

[@marjake3147]

Hey, wait! We housewives who don't have an extensive education on this are trying to keep up, too! Don't forget us!

[@TheSheekeyScienceShow]

@@marjake3147 of course not!

[@rfbead321]

@@marjake3147 Sink or swim darling!...Just kidding. You are 100% correct. I'm sure a happy medium can be accommodated with slightly longer videos as a result.

[@mcvan8763]

Your explanation is so convoluted. Difficult for a layman like me to understand the points you have made . Very difficult to understand !

[@mazedmarky]

I heard Quercetin also may inhibit the uptake of B1.. when I learned this 'was like noooo... please don't do it

[@joemoya9743]

Excellent

[@DavidA-411]

While you did a great job at connecting the dots... It seemed you lost track of heat being connected to the process. No?

[@rfbead321]

Excellent video, as usual!

[@bluellamaslearnbeyondthele2456]

Yet another variable to know almost nothing about...

[@elliottrubenstein1746]

Thank you for your work.

[@Chris-kr7gg]

Can someone break this down in a concise way for a layman.

[@joemoya9743]

Heat (steam or dry sauna) helps.

[@Chris-kr7gg]

@@joemoya9743 awesome, would there be specific amount of time for a person to be in the sauna, to reap the benefits ?

[@joeschmoe5583]

We like technical videos! There are plenty of stupid videos on the internet - let us get our tech ones!

[@joemoya9743]

@@Chris-kr7gg Starting at about 7:20 kzbin.info/www/bejne/nqXIkq2drb5gp7s In general, how long? ...depends on your adaptation and capacity to tolerate heat.

[@marjake3147]

Craig, as a fellow "layman", I will often pause the video to read the information displayed. That seems to help, and you can go at your own pace. I look forward to every post from Eleanor, and doing this helps me to keep up with the subject-

[@benjanik6297]

too dam fast

[@PFLEONARDI0906]

Slow down the playback speed to 75%, that may help….

[@ericknea]

very hard to understand , poor spelling